Aqp3

Summary

Gene Symbol: Aqp3
Description: aquaporin 3
Alias: AQP-2, aquaporin-3, AQP-3, aquaglyceroporin-3
Species: mouse

Top Publications

  1. ncbi Role of aquaporin water channels in pleural fluid dynamics
    Y Song
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    Am J Physiol Cell Physiol 279:C1744-50. 2000
  2. ncbi Aquaporin-3 functions as a glycerol transporter in mammalian skin
    Mariko Hara-Chikuma
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    Biol Cell 97:479-86. 2005
  3. ncbi Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization
    Marc H Levin
    Department of Medicine and Physiology, Cardiovascular Research Institute, Graduate Group in Biophysics, University of California, San Francisco, California 94143 0521, USA
    Invest Ophthalmol Vis Sci 47:4365-72. 2006
  4. pmc The expression of differentiation markers in aquaporin-3 deficient epidermis
    Mariko Hara-Chikuma
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Arch Dermatol Res 301:245-52. 2009
  5. doi Mitogen-activated protein kinase (MAPK) pathways mediate embryonic responses to culture medium osmolarity by regulating Aquaporin 3 and 9 expression and localization, as well as embryonic apoptosis
    Christine E Bell
    Department of Obstetrics and Gynaecology, The University of Western Ontario, London, Ontario, Canada
    Hum Reprod 24:1373-86. 2009
  6. ncbi Impaired pain sensation in mice lacking Aquaporin-1 water channels
    Kotaro Oshio
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 341:1022-8. 2006
  7. pmc Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
    Evan W Miller
    Department of Chemistry, University of California, Berkeley, 94720, USA
    Proc Natl Acad Sci U S A 107:15681-6. 2010
  8. ncbi Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens
    Julian A Guttman
    The University of British Columbia, Michael Smith Laboratories, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
    Cell Microbiol 9:131-41. 2007
  9. ncbi Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease
    V H Gattone
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160 7400, USA
    Dev Genet 24:309-18. 1999
  10. pmc Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels
    T Ma
    Departments of Medicine, Physiology, and Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    Proc Natl Acad Sci U S A 97:4386-91. 2000

Research Grants

  1. Aquaporin 5 (AQP5) in Lung Fluid Homeostasis
    CARISSA KRANE; Fiscal Year: 2004

Scientific Experts

  • Tonghui Ma
  • K Edashige
  • V H Gattone
  • Natsuko Machida
  • Tatemitsu Rai
  • K Varadaraj
  • Wendy B Bollag
  • Alan S Verkman
  • Carissa M Krane
  • Mariko Hara-Chikuma
  • Yoshiki Miyachi
  • Marc H Levin
  • B Yang
  • Dan Zhao
  • Linh Chi Bui
  • Felix J Boivin
  • Naoya Matsunaga
  • Chunfang Liu
  • Xiaofei Zhi
  • Xiangjian Zheng
  • Ivan Bedzhov
  • Nobutomo Ikarashi
  • Stine Langaa
  • Kenji Kabashima
  • Y Song
  • Haixia Qin
  • Kyoko Nakahigashi
  • Na Zhu
  • Flavia Merigo
  • Min Gyu Song
  • Jian Guo Zhu
  • Yasuaki Mohri
  • Qi Chen
  • Jun Woo Jo
  • Hans Peter Gaeggeler
  • Shunsuke Chikuma
  • Ken Kobayashi
  • Evan W Miller
  • Georg Mellitzer
  • Kleber S Parreira
  • Javier Ruiz-Ederra
  • Christine E Bell
  • Hyun Woo Jeong
  • Helga S Larsen
  • Ryosuke Makita
  • Qing Xia Meng
  • Julian A Guttman
  • Peter Igarashi
  • Jae Mi Suh
  • Kotaro Oshio
  • Andrew J Watson
  • Baoxue Yang
  • Samira Saadoun
  • Liman Qian
  • Chao Nan Qian
  • Toshiyuki Matsuzaki
  • Janet D Klein
  • S Felszeghy
  • Aline Chevallier
  • Robert Barouki
  • Stéphane Pierre
  • Lisa C Barcroft
  • Celine Tomkiewicz
  • Xavier Coumoul
  • Darren Bridgewater
  • Takeshi Watanabe
  • Sachiko Watanabe
  • Sanjay Sarin
  • Ashkan Javidan
  • Tetsuya Honda
  • Hadiseh Khalili
  • Bruno Svajger
  • Hiroki Satooka
  • Janice Lim
  • Kazufumi Itcho
  • Jin Feng
  • Yuanlin Song
  • Baofei Jiang
  • Li Yang
  • Na Lin
  • Yanfang Zheng
  • Wen Xu
  • Jinqiu Tao
  • Hao Xu
  • Deliang Huang
  • Kengo Hamamura
  • Zekuan Xu
  • Miyako Watanabe
  • Yoko Furuichi
  • Hisako Ikeyama

Detail Information

Publications74

  1. ncbi Role of aquaporin water channels in pleural fluid dynamics
    Y Song
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    Am J Physiol Cell Physiol 279:C1744-50. 2000
    ..Small amounts of AQP3 transcript were also detected in pleura by RT-PCR, but osmotic water transport was not decreased in AQP3 null mice...
  2. ncbi Aquaporin-3 functions as a glycerol transporter in mammalian skin
    Mariko Hara-Chikuma
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    Biol Cell 97:479-86. 2005
    ..In skin, the aquaglyceroporin AQP3 is expressed in the basal layer of epidermal keratinocytes...
  3. ncbi Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization
    Marc H Levin
    Department of Medicine and Physiology, Cardiovascular Research Institute, Graduate Group in Biophysics, University of California, San Francisco, California 94143 0521, USA
    Invest Ophthalmol Vis Sci 47:4365-72. 2006
    To determine a role for the water- and glycerol-transporting protein aquaporin-3 (AQP3) in mammalian corneal epithelium, where it is expressed but has no known function.
  4. pmc The expression of differentiation markers in aquaporin-3 deficient epidermis
    Mariko Hara-Chikuma
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Arch Dermatol Res 301:245-52. 2009
    Aquaporin-3 (AQP3) is a water/glycerol transporting protein expressed strongly at the plasma membrane of keratinocytes...
  5. doi Mitogen-activated protein kinase (MAPK) pathways mediate embryonic responses to culture medium osmolarity by regulating Aquaporin 3 and 9 expression and localization, as well as embryonic apoptosis
    Christine E Bell
    Department of Obstetrics and Gynaecology, The University of Western Ontario, London, Ontario, Canada
    Hum Reprod 24:1373-86. 2009
    ..We hypothesized that mitogen-activated protein kinase (MAPK) pathways mediate responses to hyperosmotic stress by regulating Aquaporin (AQP) 3 and 9 expression as well as embryonic apoptosis...
  6. ncbi Impaired pain sensation in mice lacking Aquaporin-1 water channels
    Kotaro Oshio
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 341:1022-8. 2006
    ..These results provide evidence for AQP1 expression in nociceptive neurons and suggest that AQP1 may play a role in pain signal transduction...
  7. pmc Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
    Evan W Miller
    Department of Chemistry, University of California, Berkeley, 94720, USA
    Proc Natl Acad Sci U S A 107:15681-6. 2010
    ..Here we report that the water channel Aquaporin-3 (AQP3) can facilitate the uptake of H(2)O(2) into mammalian cells and mediate downstream intracellular signaling...
  8. ncbi Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens
    Julian A Guttman
    The University of British Columbia, Michael Smith Laboratories, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
    Cell Microbiol 9:131-41. 2007
    ..rodentium infection may alter AQP localization in colonocytes. We demonstrate that during infection, AQP2 and AQP3 are mislocalized from their normal location along cell membranes to the cell cytoplasm...
  9. ncbi Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease
    V H Gattone
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160 7400, USA
    Dev Genet 24:309-18. 1999
    ..arginine vasopressin V2 receptors (AVP-V2R), and 3) the presence of appropriate CD water channels (aquaporins, AQP 2 and 3). An increase in urine osmolarity, normally seen between 1 and 3 weeks of age, was absent in cpk cystic mice...
  10. pmc Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels
    T Ma
    Departments of Medicine, Physiology, and Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    Proc Natl Acad Sci U S A 97:4386-91. 2000
    Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells...
  11. ncbi Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
    Samira Saadoun
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, USA
    Nature 434:786-92. 2005
    ..Our findings support a fundamental role of water channels in cell migration, which is central to diverse biological phenomena including angiogenesis, wound healing, tumour spread and organ regeneration...
  12. pmc Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4
    T Ma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Clin Invest 100:957-62. 1997
    ....
  13. ncbi Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3
    B Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, 94143 0521, USA
    J Biol Chem 276:624-8. 2001
    Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes...
  14. pmc Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption
    Mariko Hara-Chikuma
    Cardiovascular Research Institute, 1246 Health Sciences East Tower, Box 0521, University of California San Francisco, San Francisco, CA 94143 0521, USA
    Mol Cell Biol 28:326-32. 2008
    Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed strongly at the plasma membranes of basal epidermal cells in skin. We found that human skin squamous cell carcinoma strongly overexpresses AQP3...
  15. ncbi Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing
    Mariko Hara-Chikuma
    Department of Medicine, Cardiovascular Research Institute, University of California, 1246 Health Sciences East Tower, San Francisco, CA 94143 0521, USA
    J Mol Med (Berl) 86:221-31. 2008
    ..of basal keratinocytes in epidermis, which strongly express the water/glycerol-transporting protein aquaporin-3 (AQP3)...
  16. ncbi Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    Exp Physiol 85:233S-241S. 2000
    ..Multiple phenotype abnormalities were found in the null mice. For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria whereas AQP4 deletion produced only a mild concentrating defect...
  17. doi Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration
    Linh Chi Bui
    INSERM UMR S 1124, Toxicologie Pharmacologie et Signalisation Cellulaire, 75006 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR 8251, biologie fonctionnelle et adaptative, 75213 Paris, France and
    Toxicol Sci 149:158-66. 2016
    ..Here, we show that AQP3, which has been incriminated in cancer progression, is regulated by the AhR, or dioxin receptor...
  18. doi 24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks
    Naoya Matsunaga
    Faculty of Pharmaceutical Sciences, Division of Clinical Pharmacy, Department of Pharmaceutics, Department of Medico Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Invest Dermatol 134:1636-44. 2014
    b>Aquaporin 3 (AQP3) is located in the basal layer of the epidermis and regulates biological functions of skin such as water content and trans-epidermal water loss...
  19. doi MiR-874 promotes intestinal barrier dysfunction through targeting AQP3 following intestinal ischemic injury
    Xiaofei Zhi
    Division of Gastrointestinal Surgery, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    FEBS Lett 588:757-63. 2014
    ..Our previous study showed aquaporin 3 is involved in intestinal barrier impairment...
  20. pmc Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate-induced diarrhoea model
    Chunfang Liu
    Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China
    Biomed Res Int 2014:619465. 2014
    ..Our data showed for the first time that RTE inhibit AQPs 2 and 3 expression in vivo and in vitro via downregulating PKA/p-CREB signal pathway, which accounts for the antidiarrhoeal effect of RTE. ..
  21. pmc Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium
    Felix J Boivin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    PLoS ONE 10:e0120347. 2015
    ..We propose that β-catenin in the renal stroma modulates a genetic program in ureteric epithelium that is required for the induction of nephron progenitors. ..
  22. doi Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis
    Mariko Hara-Chikuma
    Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Nat Commun 6:7454. 2015
    b>Aquaporin 3 (AQP3), a water/glycerol channel protein, has been found to transport hydrogen peroxide (H2O2)...
  23. pmc Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin
    Ivan Bedzhov
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
    PLoS Genet 8:e1002609. 2012
    ..We provide novel insights into how ligand-dependent Igf1r activity is additionally gated to sense developmental potential in utero and into a bifunctional role of adhesion molecules in contact formation and signaling...
  24. doi Mice with targeted disruption of the acyl-CoA binding protein display attenuated urine concentrating ability and diminished renal aquaporin-3 abundance
    Stine Langaa
    Dept of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, Denmark
    Am J Physiol Renal Physiol 302:F1034-44. 2012
    ..b>AQP3 abundance was lower in ACBP(-/-) mice than in (+/+) control animals...
  25. doi Gypsum fibrosum and its major component CaSO4 increase cutaneous aquaporin-3 expression levels
    Nobutomo Ikarashi
    Department of Clinical Pharmacokinetics, Hoshi University, Shinagawa ku, Tokyo, Japan
    J Ethnopharmacol 139:409-13. 2012
    ..reported that Byakkokaninjinto improves cutaneous pruritus by increasing the expression level of aquaporin-3 (AQP3)...
  26. ncbi The role of aquaporin 3 in the movement of water and cryoprotectants in mouse morulae
    Keisuke Edashige
    Laboratory of Animal Science, College of Agriculture, Kochi University, Nankoku, Kochi 783 8502, Japan
    Biol Reprod 77:365-75. 2007
    ..that water and glycerol move across the plasma membrane by facilitated diffusion, and we have suggested that aquaporin 3 plays an important role in their movement...
  27. pmc Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake
    Mariko Hara-Chikuma
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Exp Med 209:1743-52. 2012
    ..In this study, we report that the water/glycerol channel aquaporin-3 (AQP3) is expressed on T cells and regulates their trafficking in cutaneous immune reactions...
  28. doi Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line
    Hans Peter Gaeggeler
    Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland
    Kidney Int 79:843-52. 2011
    ..The mCCD(c11) cell line is a first example of a mammalian tight epithelium allowing quantitative study of the coupling between sodium and water transport. Our data are consistent with the 'near isoosmotic' fluid transport model...
  29. doi Reduced expression and function of aquaporin-3 in mouse metaphase-II oocytes induced by controlled ovarian hyperstimulation were associated with subsequent low fertilization rate
    Qing Xia Meng
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    Cell Physiol Biochem 21:123-8. 2008
    Aquaporin-3 (AQP3), one isoform of water channel family, has been found to be expressed in mouse oocytes...
  30. pmc Expression patterns of the aquaporin gene family during renal development: influence of genetic variability
    Kleber S Parreira
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
    Pflugers Arch 458:745-59. 2009
    ....
  31. pmc Altered regulation of aquaporin gene expression in allergen and IL-13-induced mouse models of asthma
    Carissa M Krane
    Department of Biology, University of Dayton, 300 College Park, Dayton, OH 45469, USA
    Cytokine 46:111-8. 2009
    ..AQP5 mRNA was reduced in both models, whereas AQP3 was upregulated only in the IL-13 model...
  32. pmc In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency
    Javier Ruiz-Ederra
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    Invest Ophthalmol Vis Sci 50:2132-8. 2009
    ....
  33. pmc Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses
    Kulandaiappan Varadaraj
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Dev Dyn 236:1319-28. 2007
    ..To our knowledge, this is the first report on the expression patterns of AQP0 and AQP1 during lens development and differentiation and their relation to lens transparency...
  34. pmc Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice
    Hyun Woo Jeong
    Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
    J Clin Invest 119:3290-300. 2009
    ..Our data demonstrate that Notch signaling is required for the development of the mammalian renal collecting duct and principal cell differentiation and indicate that pathway dysregulation may contribute to distal renal tubular disorders...
  35. doi Aquaporin expression patterns in the developing mouse salivary gland
    Helga S Larsen
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Eur J Oral Sci 117:655-62. 2009
    ..Overall, this study demonstrates that AQP presentation varies and has a specific expression pattern during the development of mouse SMG. This feature may be important for glandular anatomical and physiological development...
  36. pmc Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
    Georg Mellitzer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    J Clin Invest 120:1708-21. 2010
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium...
  37. doi Effect of maturation on the expression of aquaporin 3 in mouse oocyte
    Jun Woo Jo
    Seoul National University Bundang Hospital, Seongnam, Gyeonggi 463 707, Korea
    Zygote 19:9-14. 2011
    This study aimed to investigate whether aquaporin 3 (Aqp3) mRNAs are expressed in immature oocytes and altered during in vitro maturation process. Five- to 6-week-old female ICR mice were primed by gonadotropin for 24 and 48 h...
  38. doi Cellular and subcellular localization of aquaporins 1, 3, 8, and 9 in amniotic membranes during pregnancy in mice
    Ken Kobayashi
    Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku ku, Tokyo, 160 8582, Japan
    Cell Tissue Res 342:307-16. 2010
    ..b>AQP3 was present in both epithelial cells and fibroblasts between E10 and E12...
  39. pmc Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration
    Qi Chen
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Cell Res 21:922-33. 2011
    ..Here, we report that aquaporin3 (AQP3) is a sperm water channel in mice and humans...
  40. doi Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia
    Kyoko Nakahigashi
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Invest Dermatol 131:865-73. 2011
    Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed in keratinocytes of the epidermis...
  41. pmc Aquaporin-3 in keratinocytes and skin: its role and interaction with phospholipase D2
    Haixia Qin
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University formerly Medical College of Georgia, Augusta, GA 30912, USA
    Arch Biochem Biophys 508:138-43. 2011
    b>Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is expressed in the epidermis, among other epithelial tissues...
  42. doi Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3
    Yasuaki Mohri
    Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Dev Dyn 240:1626-34. 2011
    ..5 in the Lgr4(-/-) was arrested earlier, and both DBA-lectin staining and immunohistochemical analysis using Aqp3 antibodies showed that the ureteric bud (UB) of Lgr4(-/-) kidneys underwent premature differentiation...
  43. doi Epithelial membrane transporters expression in the developing to adult mouse vomeronasal organ and olfactory mucosa
    Flavia Merigo
    Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Strada Le Grazie 8, Verona I 37134, Italy
    Dev Neurobiol 71:854-69. 2011
    ..that CC26, cAMP-activated chloride channel (CFTR), and the water channel protein aquaporin 2, 3, 4, and 5 (AQP2, AQP3, AQP4, and AQP5) are expressed in developing to adult chemosensory epithelia with differential timing; moreover, ..
  44. ncbi [Expressions of aquaporins 1 and 3 in the mouse prostate and their significance]
    Jian Guo Zhu
    Department of Distinguished Professor Tang Ao qing Laboratory, China Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China
    Zhonghua Nan Ke Xue 17:483-7. 2011
    ....
  45. doi Defective macrophage function in aquaporin-3 deficiency
    Na Zhu
    Central Research Laboratory, Bethune Second Hospital of Jilin University, Changchun, 130041, PR China
    FASEB J 25:4233-9. 2011
    ..We found that mouse resident peritoneal macrophages (mRPMs) express the aquaglyceroporin aquaporin-3 (AQP3) in a plasma membrane pattern...
  46. doi Role of aquaporin 3 in development, subtypes and activation of dendritic cells
    Min Gyu Song
    Department of Biochemistry, School of Medicine, Dong A University, Busan 602 714, Republic of Korea
    Mol Immunol 49:28-37. 2011
    ..b>Aquaporin 3 (AQP3), a water and glycerol transporting protein, is highly expressed in immature DCs...
  47. ncbi Aquaporin proteins in murine trophectoderm mediate transepithelial water movements during cavitation
    Lisa C Barcroft
    Department of Obstetrics and Gynaecology, The University of Western Ontario, London Ontario, Canada N6A 5C1
    Dev Biol 256:342-54. 2003
    ..b>AQP 3, 8, and 9 proteins demonstrated cell margin-associated staining starting at the 8-cell (AQP 9) or compacted morula ..
  48. ncbi Aquaporin molecular biology and clinical abnormalities of the water transport channels
    N V Knoers
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Curr Opin Pediatr 10:428-34. 1998
    ..The finding of changed AQP2 expression in several acquired water balance disorders may pave the way toward developing treatments for these clinical problems...
  49. ncbi Lessons on renal physiology from transgenic mice lacking aquaporin water channels
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    J Am Soc Nephrol 10:1126-35. 1999
    ..channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule...
  50. ncbi Aquaporin adipose, a putative glycerol channel in adipocytes
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Japan
    J Biol Chem 275:20896-902. 2000
    ..Adipose tissue expressed AQPap mRNA in high abundance, but not the mRNAs for the other aquaglyceroporins, AQP3 and AQP9, indicating that AQPap is the only known aquaglyceroporin expressed in adipose tissue...
  51. ncbi Expression of mRNAs of the aquaporin family in mouse oocytes and embryos
    K Edashige
    Laboratory of Animal Science, College of Agriculture, Kochi University, Nankoku, Kochi, 783 8502, Japan
    Cryobiology 40:171-5. 2000
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...
  52. ncbi Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5
    M Moore
    Department of Medicine, University of California, San Francisco 94143 0521, USA
    Exp Eye Res 70:557-62. 2000
    ..tear secretion was compared in wildtype mice and knockout mice lacking AQP1, AQP4 and AQP5, as well as AQP3, which was found here to be expressed in the basolateral membrane of acinar cells...
  53. ncbi mRNAs encoding aquaporins are present during murine preimplantation development
    H Offenberg
    Department of Clinical Studies, Reproduction, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Mol Reprod Dev 57:323-30. 2000
    ..These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation...
  54. pmc Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration
    Y Song
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Gen Physiol 117:573-82. 2001
    Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia...
  55. ncbi Impaired hearing in mice lacking aquaporin-4 water channels
    J Li
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 276:31233-7. 2001
    ..response (ABR) thresholds were compared in wild-type mice and transgenic null mice lacking (individually) AQP1, AQP3, AQP4, and AQP5...
  56. ncbi A phylogenetic framework for the aquaporin family in eukaryotes
    R Zardoya
    Museo Nacional de Ciencias Naturales, CSIC, Jose Gutierrez Abascal 2, 28006, Madrid, Spain
    J Mol Evol 52:391-404. 2001
    ..into six major paralogous groups: (1) GLPs, or glycerol-transporting channel proteins, which include mammalian AQP3, AQP7, and AQP9, several nematode paralogues, a yeast paralogue, and Escherichia coli GLP; (2) AQPs, or aquaporins, ..
  57. ncbi Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3
    Tonghui Ma
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:17147-53. 2002
    ..The water/small solute-transporting protein aquaporin-3 (AQP3) was found by immunofluorescence and immunogold electron microscopy to be expressed at the plasma membrane of ..
  58. ncbi Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea
    Deliang Huang
    Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, 2100 West Third Street, House Ear Institute, Los Angeles, CA 90057, USA
    Hear Res 165:85-95. 2002
    ..We report here that AQP3, AQP7 and AQP9 were expressed in the inner ear...
  59. pmc Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice
    Yuanlin Song
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    J Physiol 541:561-8. 2002
    ..These results indicate the expression of AQP5 in sweat gland secretory epithelium, but provide direct evidence against its physiological involvement in sweat fluid secretion in mice...
  60. ncbi Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery
    Mariko Hara
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:46616-21. 2002
    Deletion of the epidermal water/glycerol transporter aquaporin-3 (AQP3) in mice reduced superficial skin conductance by approximately 2-fold (Ma, T., Hara, M., Sougrat, R., Verbavatz, J. M., and Verkman, A. S. (2002) J. Biol. Chem...
  61. ncbi Role of aquaporin water channels in eye function
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, 1246 Health Sciences East Tower, San Francisco, CA 94143 0521, USA
    Exp Eye Res 76:137-43. 2003
    ..the eye: AQP0 (MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary epithelium and retinal Müller cells, and AQP5 in corneal and lacrimal gland ..
  62. doi Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
    Ryosuke Makita
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Renal Physiol 294:F542-53. 2008
    ..Thus TAZ is essential for developmental mechanisms involved in kidney and lung organogenesis, whose disturbance may lead to the pathogenesis of common human diseases...
  63. ncbi Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation
    Xiangjian Zheng
    Program in Cell Signaling, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 121:1487-95. 2003
    b>Aquaporin 3 is a channel that transports both water and glycerol. Aquaporin 3-deficient mice exhibit skin defects, including decreased glycerol content and impairment of water holding capacity, barrier recovery, and wound healing...
  64. ncbi Expression of aquaporin isoforms during human and mouse tooth development
    S Felszeghy
    Department of Anatomy, Histology and Embryology, Medical and Health Science Centre, University of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
    Arch Oral Biol 49:247-57. 2004
    ..AQP2, AQP3 and AQP9 immunoreactivity was not observed in tooth germs, whereas strong AQP4 and AQP5 expression was observed in ..
  65. ncbi Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B
    Janet D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    J Am Soc Nephrol 15:1161-7. 2004
    ..and Northern blot analysis showed upregulation of the UT-A2 urea transporter and the aquaporin 2 (AQP2) and AQP3 water channel transcripts but no change in other urea transporters or AQP...
  66. ncbi Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium
    Chao Nan Qian
    Laboratories of Cancer Genetics and Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49508, USA
    J Biol Chem 280:3938-45. 2005
    ..Our results confirm an important role for proper regulation of Wnt/beta-catenin signaling in renal development and provide evidence that dysregulation of the pathway can initiate tumorigenesis in the kidney...
  67. ncbi Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva
    Marc H Levin
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0521, USA
    Invest Ophthalmol Vis Sci 45:4423-32. 2004
    ....
  68. ncbi Expression and immunolocalization of water-channel aquaporins in the rat and mouse mammary gland
    Toshiyuki Matsuzaki
    Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Showa machi 3 39 22, Maebashi, Gunma 371 8511, Japan
    Histochem Cell Biol 123:501-12. 2005
    ..RT-PCR and immunoblotting revealed the expression of aquaporin-1 (AQP1) and AQP3 in the lactating rat mammary gland...
  69. ncbi More than just water channels: unexpected cellular roles of aquaporins
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, Room 1246, Box 0521 University of California San Francisco, San Francisco, CA 94143 0521, USA
    J Cell Sci 118:3225-32. 2005
    ..The many roles of AQPs could be exploited for clinical benefit; for example, treatments that modulate AQP expression/function could be used as diuretics, and in the treatment of brain swelling, glaucoma, epilepsy, obesity and cancer...
  70. ncbi Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal
    Tatemitsu Rai
    Dept of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental Univ, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Cell Physiol 290:C298-304. 2006
    ..AQP2 is specifically targeted to the apical cell domain, whereas AQP3 and AQP4 are expressed on the basolateral membrane...
  71. ncbi Channel-dependent permeation of water and glycerol in mouse morulae
    Keisuke Edashige
    Laboratory of Animal Science, College of Agriculture, Kochi University, Nankoku, Kochi 783 8502, Japan
    Biol Reprod 74:625-32. 2006
    ..By immunocytochemical analysis, aquaporin 3, which transports not only water but also glycerol, was detected in the morulae but not in the oocytes...
  72. ncbi Urea and urine concentrating ability in mice lacking AQP1 and AQP3
    Dan Zhao
    Department of Medicine, University of California, San Francisco 94143 0521, USA
    Am J Physiol Renal Physiol 291:F429-38. 2006
    Aquaporin-1 (AQP1) and aquaporin-3 (AQP3) water channels expressed in the kidney play a critical role in the urine concentrating mechanism. Mice with AQP1 or AQP3 deletion have a urinary concentrating defect...
  73. ncbi The expression profiles of nuclear receptors in the developing and adult kidney
    Jae Mi Suh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:3412-20. 2006
    ..Our results suggest that these nuclear receptors are likely to play important physiological roles in the kidney development...
  74. ncbi A potential role for the phospholipase D2-aquaporin-3 signaling module in early keratinocyte differentiation: production of a phosphatidylglycerol signaling lipid
    Wendy B Bollag
    Department of Medicine Dermatology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 127:2823-31. 2007
    In keratinocytes aquaporin-3 (AQP3), an efficient glycerol transporter, is associated with phospholipase D2 (PLD2) in caveolin-rich membrane microdomains...

Research Grants1

  1. Aquaporin 5 (AQP5) in Lung Fluid Homeostasis
    CARISSA KRANE; Fiscal Year: 2004
    ..This combinatorial approach will provide valuable information for the identification of new mechanistic pathways critical for the development of novel drug targets for the treatment of asthma. ..