Apoe

Summary

Gene Symbol: Apoe
Description: apolipoprotein E
Alias: AI255918, Apo-E, apolipoprotein E
Species: mouse

Top Publications

  1. pmc Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:185-94. 2007
  2. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
  3. ncbi Natural regulatory T cells control the development of atherosclerosis in mice
    Hafid Ait-Oufella
    Institut National de la Sante et de la Recherche Medicale INSERM, Unit 689, Centre de Recherché Cardiovasculaire Lariboisière, 41, Bd de la Chapelle, 75010 Paris, France
    Nat Med 12:178-80. 2006
  4. pmc Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes 59:1030-7. 2010
  5. ncbi Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    S H Zhang
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 258:468-71. 1992
  6. pmc Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:1273-82. 2006
  7. pmc Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    Zubair Shah
    Davis Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH 43210, USA
    Circulation 124:2338-49. 2011
  8. pmc A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, Germany
    J Exp Med 196:887-96. 2002
  9. ncbi Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    Nature 394:894-7. 1998
  10. ncbi The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
    Veronica Hirsch-Reinshagen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada
    J Biol Chem 280:43243-56. 2005

Research Grants

  1. Interaction of ApoE with Estrogen in the Olfactory System
    Britto Nathan; Fiscal Year: 2008
  2. APOE EFFECT ON CNS NEURONS--ROLE OF LRP
    David Holtzman; Fiscal Year: 2003
  3. CNS/plasma ABeta clearance of anti-ABeta antibody
    David Holtzman; Fiscal Year: 2003
  4. EFFECTS OF AGING & PGP ON AB EFFLUX FROM THE BRAIN
    ANNE FAGAN NIVEN; Fiscal Year: 2005
  5. EXPERIMENTAL EMPHYSEMA--STUDIES ON REMEDIATION
    Donald Massaro; Fiscal Year: 2001
  6. REMEDIATION OF EMPHYSEMA--MECHANISMS, CHARACTERISTICS
    Donald Massaro; Fiscal Year: 2001
  7. Alveolar Biology: Sex, Age, and Alveolar Turnover
    Donald Massaro; Fiscal Year: 2007
  8. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
  9. QTL analysis of carotid atherosclerosis
    Weibin Shi; Fiscal Year: 2007
  10. APOE4 and Loss of Synaptic Integrity
    Patrick Sullivan; Fiscal Year: 2009

Detail Information

Publications214 found, 100 shown here

  1. pmc Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:185-94. 2007
    ..Here, we analyzed mouse monocyte subsets in apoE-deficient mice and traced their differentiation and chemokine receptor usage as they accumulated within ..
  2. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    b>apoE-deficient mice have been created by homologous recombination in ES cells...
  3. ncbi Natural regulatory T cells control the development of atherosclerosis in mice
    Hafid Ait-Oufella
    Institut National de la Sante et de la Recherche Medicale INSERM, Unit 689, Centre de Recherché Cardiovasculaire Lariboisière, 41, Bd de la Chapelle, 75010 Paris, France
    Nat Med 12:178-80. 2006
    ..These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells...
  4. pmc Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes 59:1030-7. 2010
    ..The aim of this study was to investigate the effects of GLP-1 on accumulation of monocytes/macrophages on the vascular wall, one of the earliest steps in atherosclerogenesis...
  5. ncbi Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    S H Zhang
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 258:468-71. 1992
    b>Apolipoprotein E (apoE) is a ligand for receptors that clear remnants of chylomicrons and very low density lipoproteins...
  6. pmc Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:1273-82. 2006
    ..Atherosclerosis induces the recruitment of macrophages and dendritic cells that support antigen presentation...
  7. pmc Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    Zubair Shah
    Davis Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH 43210, USA
    Circulation 124:2338-49. 2011
    ..Because DPP-4 is expressed in inflammatory cells, we hypothesized that its inhibition will exert favorable effects in atherosclerosis...
  8. pmc A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, Germany
    J Exp Med 196:887-96. 2002
    ..Here, we show in vivo that platelets adhere to the vascular endothelium of the carotid artery in ApoE(-)(/)(-) mice before the development of manifest atherosclerotic lesions...
  9. ncbi Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    Nature 394:894-7. 1998
    ..Here we show that the selective absence of CCR2 decreases lesion formation markedly in apoE-/- mice but has no effect on plasma lipid or lipoprotein concentrations...
  10. ncbi The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
    Veronica Hirsch-Reinshagen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada
    J Biol Chem 280:43243-56. 2005
    ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be required to maintain normal apoE levels and lipidation in the central nervous system...
  11. pmc Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
    Yaisa Andrews-Zwilling
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:13707-17. 2010
    ..Consequently, reducing Tau and enhancing GABA signaling are potential strategies to treat or prevent apoE4-related Alzheimer's disease...
  12. doi Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice
    Courtney P Judkins
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Am J Physiol Heart Circ Physiol 298:H24-32. 2010
    ..Here we investigated the role of the Nox2-containing NADPH oxidase in atherogenesis in apolipoprotein E-null (ApoE(-/-)) mice...
  13. pmc Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
    Faith M Harris
    Gladstone Institute of Neurological Disease, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 100:10966-71. 2003
    ..However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation of ..
  14. doi Endothelial arginase II: a novel target for the treatment of atherosclerosis
    Sungwoo Ryoo
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Circ Res 102:923-32. 2008
    ..Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet...
  15. ncbi Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice
    P M Sullivan
    Bryan Alzheimer s Disease Research Center and Division of Neurology, Department of Medicine, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Neuroscience 124:725-33. 2004
    ..three human apolipoprotein (apo) E targeted replacement mouse lines, each expressing one of the three common human apoE isoforms to study the pattern of apoE expression in the central nervous system (CNS)...
  16. ncbi Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress
    Karen S Meir
    Department of Pathology, Hadassah University Hospital, Kiryat Hadassah, Jerusalem, Israel
    Arterioscler Thromb Vasc Biol 24:1006-14. 2004
    ..Among available models, the apolipoprotein E-deficient (apoE-/-) mouse is particularly popular because of its propensity to spontaneously develop ..
  17. ncbi Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice
    R K Tangirala
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Lipid Res 36:2320-8. 1995
    ..In other models such as LDL receptor-deficient and apoE-deficient mice, diet-induced or spontaneous hypercholesterolemia and atherogenesis are much greater...
  18. ncbi Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    P M Sullivan
    Department of Pathology and Laboratory of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Biol Chem 272:17972-80. 1997
    ..We found, however, notable differences in the distribution of plasma lipoproteins and apolipoprotein E between the two groups: beta-migrating lipoproteins and plasma apoB100 levels are decreased in the 3/3 mice, ..
  19. pmc Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice
    Masanori Ozaki
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 110:331-40. 2002
    ..We crossed eNOS-overexpressing (eNOS-Tg) mice with atherogenic apoE-deficient (apoE-KO) mice to determine whether eNOS overexpression in the endothelium could inhibit the development ..
  20. ncbi Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
    Murray C H Clarke
    Division of Cardiovascular Medicine, University of Cambridge, Box 110, ACCI, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Nat Med 12:1075-80. 2006
    ..In contrast, VSMC apoptosis in atherosclerotic plaques of SM22alpha-hDTR Apoe-/- mice induced marked thinning of fibrous cap, loss of collagen and matrix, accumulation of cell debris and ..
  21. pmc Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice
    Giuseppina Caligiuri
    INSERM U460, Paris, France
    Mol Med 9:10-7. 2003
    ..The aim of this study was to assess the effect of IL-10 deficiency in the apolipoprotein E knockout mouse...
  22. ncbi Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice
    Sven Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 110:3062-7. 2004
    ..Angiotensin II type 1 (AT1) receptor activation is potentially involved in the multifactorial pathogenesis of atherosclerosis...
  23. doi Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice
    Duo Jiao Wu
    Department of Cellular and Molecular Biology, State Key Laboratory of Medical Genomics at Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Hypertension, Shanghai, China
    Atherosclerosis 207:68-73. 2009
    ..Sixty apolipoprotein E-knockout (apoE-KO) mice were fed a high-fat diet...
  24. ncbi Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice
    T Hayek
    Lipid Research Laboratory, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Israel
    Biochem Biophys Res Commun 201:1567-74. 1994
    b>Apo E-deficient mice which are highly atherogenic animals were used in order to study their plasma and lipoprotein lipid peroxidation in the absence or presence of oxidative stress...
  25. ncbi Improvement of endothelial function by systemic transfusion of vascular progenitor cells
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Circ Res 99:e74-83. 2006
    ..b>Apolipoprotein E-deficient (apoE-/-) mice were splenectomized and treated with high-cholesterol diet for 5 weeks, resulting in ..
  26. ncbi Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Arterioscler Thromb Vasc Biol 27:850-7. 2007
    ..The present study analyzed the effect of glutathione peroxidase-1 deficiency on atherogenesis in the apolipoprotein E-deficient mouse.
  27. doi Atherosclerotic plaque disruption induced by stress and lipopolysaccharide in apolipoprotein E knockout mice
    Mei Ni
    Shandong Univ Qilu Hospital, No 107, Wen Hua Xi Road, Jinan, Shandong 250012, P R China
    Am J Physiol Heart Circ Physiol 296:H1598-606. 2009
    To establish an animal model with disruptions of atherosclerotic plaques, 96 male apolipoprotein E knockout (apoE(-/-)) mice were randomly divided into stress, lipopolysaccharide (LPS), stress+LPS, and control groups (n = 24 each)...
  28. pmc Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
    Noelia A-Gonzalez
    Immune Signaling Laboratory, Department of Biochemistry and Molecular Biology, School of Medicine, University of Las Palmas, ULPGC, 35016 Las Palmas, Spain
    Immunity 31:245-58. 2009
    ..Thus, activation of LXR by apoptotic cells engages a virtuous cycle that promotes their own clearance and couples engulfment to the suppression of inflammatory pathways...
  29. doi Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice
    Florence Bietrix
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 30:931-7. 2010
    ....
  30. pmc Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets
    Aaron Erdely
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15253. 2010
    ..and on global arginine bioavailability (defined as the ratio of plasma arginine to ornithine + citrulline) in apoE(-/-) and wild-type C57BL/6J mice. HC and HF diets led to reduced global arginine bioavailability in both strains...
  31. pmc Apolipoprotein E induces antiinflammatory phenotype in macrophages
    Daniel Baitsch
    Center for Laboratory Medicine, University Hospital Munster, and Leibniz Institute for Arteriosclerosis Research, University of Munster, Albert Schweizer Strasse 33, 48129 Munster, Germany
    Arterioscler Thromb Vasc Biol 31:1160-8. 2011
    b>Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages.
  32. pmc Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
    M Barton
    Cardiology, University Hospital Zürich and Cardiovascular Research Laboratory, Institute of Physiology, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:14367-72. 1998
    ..b>Apolipoprotein E (apoE)-deficient mice and C57BL/6 control mice were treated with a Western-type diet to accelerate ..
  33. pmc Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model
    B Ludewig
    Institute of Experimental Immunology, Department of Pathology, and Institute for Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:12752-7. 2000
    ..cardiomyocytes and in smooth muscle cells in lung arteries and the aorta (SM-LacZ), and hypercholesterolemic apolipoprotein E-deficient SM-LacZ mice (SM-LacZ/apoE(-/-)) developed myocarditis and arteritis after immunization with ..
  34. ncbi Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse
    M E Rosenfeld
    Department of Pathology, University of Washington, Seattle 98195, USA
    Arterioscler Thromb Vasc Biol 20:2587-92. 2000
    ..We previously mapped the distribution of lesions throughout the arterial tree of apolipoprotein E knockout (apoE(-/-)) mice between the ages of 24 and 60 weeks...
  35. ncbi Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation
    Manuel Buttini
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Neurosci 22:10539-48. 2002
    ..However, it is uncertain whether Abeta deposition into plaques is the main mechanism by which apoE isoforms affect AD...
  36. ncbi Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice
    Ziad Mallat
    Institut National de la Sante et de la Recherche Medicale, INSERM U541, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Paris, France
    Circulation 108:1232-7. 2003
    ....
  37. ncbi Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice
    Songwen Zhang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circulation 111:3457-64. 2005
    Normal chow (low fat)-fed mice deficient in both the HDL receptor SR-BI and apolipoprotein E (SR-BI/apoE dKO) provide a distinctive model of coronary heart disease (CHD)...
  38. pmc LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression
    Jonathan E Feig
    Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York, USA
    J Clin Invest 120:4415-24. 2010
    ..To extend these results, atherosclerotic Apoe-/- mice sufficient or deficient in CCR7 were treated with an LXR agonist, resulting in a CCR7-dependent decrease in ..
  39. pmc Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
    J A Piedrahita
    Department of Pathology and Curriculum in Genetics, University of North Carolina, Chapel Hill 27599 7525
    Proc Natl Acad Sci U S A 89:4471-5. 1992
    We have inactivated the endogenous apolipoprotein E (apoE) gene by using gene targeting in mouse embryonic stem (ES) cells...
  40. ncbi Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
    R L Reddick
    Department of Pathology, School of Medicine, University of North Carolina at Chapel Hill 27599 7525
    Arterioscler Thromb 14:141-7. 1994
    b>Apolipoprotein E-deficient mice have spontaneous elevations of total plasma cholesterol and triglycerides and reduced high-density lipoprotein. The mice develop arterial lesions in a time-dependent manner...
  41. pmc Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice
    Jennifer J Manning-Tobin
    Lipid Metabolism Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 29:19-26. 2009
    ..To test the impact of deleting these receptors, we generated Apoe(-/-) mice lacking both SR-A and CD36 and fed them a Western diet for 12 weeks.
  42. ncbi Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice
    T C Dawson
    Department of Pathology and Laboratory Medicine, University of North Carolina Medical School, Chapel Hill 27599 7525, USA
    Atherosclerosis 143:205-11. 1999
    ..CC chemokine receptor CCR2, plays a role in atherogenesis, CCR2-deficient animals were crossed with mice lacking apo E, a well characterized model of atherosclerosis...
  43. ncbi Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis
    D M Shih
    Division of Cardiology, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 275:17527-35. 2000
    ..We generated combined PON1 knockout (KO)/apolipoprotein E (apoE) KO and apoE KO control mice to compare atherogenesis and lipoprotein oxidation...
  44. ncbi Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism
    Robert L Raffai
    Gladstone Institutes of Cardiovascular Disease and Neurological Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 277:11064-8. 2002
    In creating an allelic variant of mouse Apoe designed to resemble human apolipoprotein E4 (apoE4), we generated hypomorphic apoE (hypoE) mice that express only approximately 5% of normal apoE mRNA levels in all tissues...
  45. ncbi Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
    Yuqing Huo
    Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia, Health Science Center, Charlottesville, Virginia, USA
    Nat Med 9:61-7. 2003
    ..and platelet-leukocyte aggregates cause the development of atherosclerotic lesions in apolipoprotein-E-deficient (Apoe(-/-)) mice...
  46. pmc Disruption of TGF-beta signaling in T cells accelerates atherosclerosis
    Anna Karin L Robertson
    Center for Molecular Medicine, L8 03 Karolinska Hospital, SE 17176 Stockholm, Sweden
    J Clin Invest 112:1342-50. 2003
    ..We crossed atherosclerosis-prone ApoE-knockout mice with transgenic mice carrying a dominant negative TGF-beta receptor II in T cells...
  47. pmc ApoE deficiency compromises the blood brain barrier especially after injury
    N Methia
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Med 7:810-5. 2001
    b>Apolipoprotein E (apoE) mediates lipoprotein uptake by receptors such as the LDL receptor (LDLR). The isoform apoE4 has been linked to Alzheimer's disease and to poor outcomes after brain injury...
  48. ncbi Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    FASEB J 20:797-9. 2006
    Inheritance of APOE alleles is associated with varying clinical outcomes in several neurodegenerative diseases that are associated with innate immune response in brain...
  49. ncbi Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
    D M Holtzman
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 47:739-47. 2000
    The epsilon4 allele of apolipoprotein E (ApoE) is an important genetic risk factor for Alzheimer's disease (AD)...
  50. ncbi Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice
    A Law
    Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Que, Verdun, Canada H4H 1R3
    Neurobiol Aging 24:187-90. 2003
    Impairments in cognitive performance have been observed in aged apolipoprotein E (apoE)-deficient mice, and apoE epsilon 4 allele is a risk factor in Alzheimer's disease (AD)...
  51. doi Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A
    Katey Rayner
    Vascular Biology Laboratory, Division of Cardiology, Room H 263, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circ Res 103:133-41. 2008
    ..HSP27 overexpressing (HSP27o/e) mice were crossed to apoE-/- mice that develop atherosclerosis when fed a high-fat diet...
  52. doi Toll-like receptor 4 is involved in human and mouse vein graft remodeling, and local gene silencing reduces vein graft disease in hypercholesterolemic APOE*3Leiden mice
    Jacco C Karper
    Department of Vascular Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:1033-40. 2011
    ..The goal of this study was to explore the role of Toll-like receptor 4 (TLR4) in vein graft remodeling and disease...
  53. pmc Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors
    Jens Brodbeck
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:17217-26. 2011
    ..Correcting the pathological structure of apoE4 by disrupting domain interaction is a potential therapeutic approach to treat or prevent AD related to apoE4...
  54. ncbi Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice
    P J Kuhlencordt
    Cardiovascular Research Center, Cardiology Division, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Circulation 104:448-54. 2001
    To test whether deficiency in endothelial nitric oxide synthase (eNOS) affects atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-double knockout (DKO) and apoE-knockout (KO) control animals.
  55. ncbi Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice
    Walter J Brecht
    Gladstone Institute of Neurological Disease, San Francisco, California 94141 9100, USA
    J Neurosci 24:2527-34. 2004
    b>Apolipoprotein E (apoE) is found in amyloid plaques and neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brains, but its role in their pathogenesis is unclear...
  56. ncbi Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc
    Faith M Harris
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 279:44795-801. 2004
    ..Thus, increased tau phosphorylation in apoE4 transgenic mice was associated with Erk activation and could be modified by zinc, suggesting that apoE4 and zinc act in concert to contribute to the pathogenesis of AD...
  57. ncbi Native C-reactive protein increases whereas modified C-reactive protein reduces atherosclerosis in apolipoprotein E-knockout mice
    Susanne B Schwedler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Circulation 112:1016-23. 2005
    ..We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model...
  58. pmc Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene
    Zhiguang Su
    Department of Radiology, University of Virginia, Charlottesville 22908, USA
    Genetics 172:1799-807. 2006
    ..B6) and C3H/HeJ (C3H) differ significantly in atherosclerosis susceptibility and plasma lipid levels on the apolipoprotein E-deficient (apoE-/-) background when fed a Western diet...
  59. doi ApoE(-/-)/lysozyme M(EGFP/EGFP) mice as a versatile model to study monocyte and neutrophil trafficking in atherosclerosis
    Pierre Rotzius
    Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Atherosclerosis 202:111-8. 2009
    ..Therefore, we generated ApoE(-/-)/Lysozyme M(EGFP/EGFP) mice and investigated whether targeted cell types could be visualized by in vivo ..
  60. doi Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis
    Ralph Gareus
    Institute of Genetics, Centre for Molecular Medicine CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Zülpicher Str 47, 50674 Cologne, Germany
    Cell Metab 8:372-83. 2008
    ..IkappaBalpha specifically in endothelial cells, resulted in strongly reduced atherosclerotic plaque formation in ApoE(-/-) mice fed with a cholesterol-rich diet...
  61. pmc Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms
    Kimio Satoh
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Nat Med 15:649-56. 2009
    ..Using the angiotensin II (AngII)-induced AAA model in Apoe-/- mice, we show that Apoe-/-Ppia-/- mice are completely protected from AngII-induced AAA formation, in contrast to ..
  62. doi Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice
    Kelly R Bales
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 29:6771-9. 2009
    To investigate the role of human apolipoprotein E (apoE) on Abeta deposition in vivo, we crossed PDAPP mice lacking mouse Apoe to targeted replacement mice expressing human apoE (PDAPP/TRE2, PDAPP/TRE3, or PDAPP/TRE4)...
  63. pmc Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice
    Pierre Rotzius
    Departments of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Am J Pathol 177:493-500. 2010
    ..However, recent data suggest that neutrophils also may be of importance in atherogenesis. Here, we use apolipoprotein E (ApoE)-deficient mice with fluorescent neutrophils and monocytes (ApoE(-/-)/Lys(EGFP/EGFP) mice) to ..
  64. pmc Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice
    Manuel Buttini
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158 2261, USA
    Am J Pathol 177:563-9. 2010
    The lipid transport protein apolipoprotein E (apoE) is abundantly expressed in the brain. Its main isoforms in humans are apoE2, apoE3, and apoE4...
  65. pmc Apo E structure determines VLDL clearance and atherosclerosis risk in mice
    C Knouff
    Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    J Clin Invest 103:1579-86. 1999
    We have generated mice expressing the human apo E4 isoform in place of the endogenous murine apo E protein and have compared them with mice expressing the human apo E3 isoform...
  66. pmc Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice
    G Caligiuri
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Proc Natl Acad Sci U S A 96:6920-4. 1999
    ..Here we show that hypercholesterolemic apolipoprotein E-/- low density lipoprotein receptor-/- mice develop not only coronary atherosclerosis but also myocardial ..
  67. ncbi Novel tocotrienols of rice bran inhibit atherosclerotic lesions in C57BL/6 ApoE-deficient mice
    A A Qureshi
    Advanced Medical Research, Madison, WI 53719, USA
    J Nutr 131:2606-18. 2001
    ..These compounds were also tested in wild-type C57BL/6 apoE (+/+) and (+/-) mice fed low or high fat diets...
  68. pmc Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17795-800. 2004
    ..Fractalkine-deficient mice on the C57BL/6 (B6) background were bred to the atherosclerosis-sensitizing B6.ApoE(-/-) and B6.LDLR(-/-) backgrounds...
  69. ncbi Spontaneously hyperlipidemic (SHL) mice: Japanese wild mice with apolipoprotein E deficiency
    Y Matsushima
    Saitama Cancer Center Research Institute, 818 Komuro, Ina, Saitama 362 0806, Japan
    Mamm Genome 10:352-7. 1999
    ..Immunoblot and Northern blot analyses failed to detect apolipoprotein E (APOE) expression in these animals...
  70. ncbi Genetic background determines the extent of atherosclerosis in ApoE-deficient mice
    H M Dansky
    Laboratory of Biochemical Genetics, Rockefeller University, New York, NY 10021, USA
    Arterioscler Thromb Vasc Biol 19:1960-8. 1999
    Two strains of ApoE-deficient mice were found to have markedly different plasma lipoprotein profiles and susceptibility to atherosclerosis when fed either a low-fat chow or a high-fat Western-type diet...
  71. ncbi Four strains of spontaneously hyperlipidemic (SHL) mice: phenotypic distinctions determined by genetic backgrounds
    Y Matsushima
    Research Institute, Saitama Cancer Center, Ina, Japan
    J Atheroscler Thromb 8:71-9. 2001
    Spontaneously hyperlipidemic (SHL) mice are Japanese wild mice (KOR) with disruption of the apolipoprotein E (Apo E) gene...
  72. ncbi Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice
    Weibin Shi
    Department of Radiology, University of Virginia, Charlottesville 22908, USA
    Biochem Biophys Res Commun 317:223-9. 2004
    ..b>Apolipoprotein E (apoE) is a multifunctional protein synthesized by hepatocytes and macrophages...
  73. pmc Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice
    Gideon M Hirschfield
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 102:8309-14. 2005
    ..development, progression, or severity of spontaneous atherosclerosis, or on morbidity or mortality, in male apolipoprotein E (apoE)-deficient C57BL/6 mice up to 56 weeks, despite deposition of human CRP and mouse complement component ..
  74. doi Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development
    Bart Lammers
    Gorlaeus Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Atherosclerosis 205:420-6. 2009
    ATP-binding cassette transporter G1 (Abcg1) and apolipoprotein E (Apoe) play a role in macrophage cholesterol efflux and consequently the development of atherosclerosis...
  75. pmc The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice
    Ruth D Lewis
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Immunol 47:1098-105. 2010
    ..To examine the roles of the membrane attack complex of complement and its sole membrane regulator, CD59, in atherosclerosis...
  76. doi Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins
    Izabela Rozenberg
    Cardiovascular Research, Institute of Physiology, University of Zurich, Switzerland
    Arterioscler Thromb Vasc Biol 30:923-30. 2010
    ..Histamine is known to increase vascular permeability. Whether this affects the formation of atherosclerotic lesions, however, remains elusive...
  77. doi Macrophage, but not systemic, apolipoprotein E is necessary for macrophage reverse cholesterol transport in vivo
    Ilaria Zanotti
    Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Universita di Parma, 43100 Parma, Italy
    Arterioscler Thromb Vasc Biol 31:74-80. 2011
    ..To assess the role of apolipoprotein (apo) E in macrophage reverse cholesterol transport (RCT) in vivo...
  78. pmc Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
    J D Smith
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:8264-8. 1995
    ..the osteopetrotic (op) mutation in the macrophage colony-stimulating factor gene was bred onto the apolipoprotein E (apoE)-deficient background...
  79. ncbi Requirement for CD154 in the progression of atherosclerosis
    E Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, P Debeyeln 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Nat Med 5:1313-6. 1999
    ..Here, we determined the effect of genetic disruption of CD154 in ApoE-/- mice in both initial and advanced atherosclerotic lesions. Plaque area was reduced 550%...
  80. ncbi Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice
    Lena Brånén
    Department of Medicine, University Hospital MAS, Experimental Cardiovascular Research, Wallenberg Laboratory, Ing 46, Plan 1, S 205 02 Malmo, Sweden
    Arterioscler Thromb Vasc Biol 24:2137-42. 2004
    ..The aim of the study was to evaluate the importance of TNF-alpha in atherogenesis...
  81. ncbi Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
    Romeo Ricci
    Cardiovascular Research, Institute of Physiology, and Division of Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
    Science 306:1558-61. 2004
    ..We show that atherosclerosis-prone ApoE-/- mice simultaneously lacking JNK2 (ApoE-/- JNK2-/- mice), but not ApoE-/- JNK1-/- mice, developed less ..
  82. pmc Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation
    W A Boisvert
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 96:1118-24. 1995
    b>Apo E, a key regulator of cholesterol-rich lipoprotein metabolism, is synthesized by numerous extrahepatic tissues...
  83. pmc Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice
    J H Qiao
    Department of Medicine, Molecular Biology Institute, University of California, Los Angeles, USA
    Am J Pathol 150:1687-99. 1997
    ..was induced either by feeding the mice a high fat, high cholesterol diet or by crossing op mice with apolipoprotein E (apo E) knockout mice to generate mice lacking both M-CSF and apo E...
  84. pmc Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease
    D M Holtzman
    Department of Neurology, Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 103:R15-R21. 1999
    The epsilon4 allele of apolipoprotein E (apo E) is associated with an increased risk for developing Alzheimer's disease (AD). This may be due to interactions between apo E and the amyloid-beta protein (Abeta)...
  85. ncbi Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations
    J Raber
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Neurosci 20:2064-71. 2000
    ..In the current study, we demonstrate that apolipoprotein E (apoE) deficiency results in age-dependent dysregulation of the HPA axis through a mechanism affecting ..
  86. ncbi Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice
    F Calara
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0682, USA
    J Pathol 195:257-63. 2001
    b>Apolipoprotein E-deficient (apoE(-/-)) and LDL receptor-deficient (LDLR(-/-)) mice develop extensive atherosclerosis, but the occurrence of spontaneous plaque rupture and secondary thrombosis in these models has not been established...
  87. ncbi Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice
    Hirokazu Kirii
    Department of Clinical Laboratory Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Arterioscler Thromb Vasc Biol 23:656-60. 2003
    ..We focused on the role of interleukin-1beta (IL-1beta), one of the proinflammatory cytokines secreted by monocytes/macrophages, in the progression of atherosclerosis...
  88. pmc The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice
    Piers Davenport
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre Level 5 Block E, 246 Clayton Road, Clayton, Victoria, Australia 3168
    Am J Pathol 163:1117-25. 2003
    ..of Th1 and Th2 helper cell subsets to atherogenesis was studied in a murine model by interbreeding apolipoprotein E-deficient (apoE(-/-)) mice with mice deficient in key cytokines that drive either Th1 responses [interleukin (..
  89. ncbi Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis
    Bernhard Schieffer
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Circulation 110:3493-500. 2004
    ..Mediators of inflammation, ie, interleukin (IL)-6, are elevated in patients with acute coronary syndromes and may contribute to the exacerbation of atherosclerosis...
  90. ncbi The RAGE axis in early diabetic retinopathy
    Gaetano R Barile
    Department of Ophthalmology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Invest Ophthalmol Vis Sci 46:2916-24. 2005
    ..This study was conducted to characterize the role of the RAGE axis in a murine model of nonproliferative diabetic retinopathy (NPDR)...
  91. ncbi Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice
    Marit Westerterp
    The Netherlands Organization for Applied Scientific Research Quality of Life, Department of Biomedical Research, Gaubius Laboratory, Leiden, The Netherlands
    Circulation 116:2173-81. 2007
    ..Because apolipoprotein C-I (apoCI) enhances the LPS-induced inflammatory response in macrophages in vitro and in mice, we investigated the effect of endogenous apoCI expression on LPS-induced atherosclerosis in mice...
  92. pmc CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice
    Guipeng An
    Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Room 1254 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Immunol 46:1702-9. 2009
    ..DAF(-/-) and CD59(-/-) mice were crossed with apolipoprotein E (ApoE)-deficient mice to generate DAF(-/-)ApoE(-/-) and CD59(-/-)ApoE(-/-) mice...
  93. doi Transcription profiles of aortic smooth muscle cells from atherosclerosis-prone and -resistant regions in young apolipoprotein E-deficient mice before plaque development
    Tim Van Assche
    Division of Pharmacology, Faculties of Medicine, University of Antwerp, Wilrijk, Belgium
    J Vasc Res 48:31-42. 2011
    ..We investigated whether the transcriptome of smooth muscle cells is different between atherosclerosis-prone and atherosclerosis-resistant regions in apolipoprotein E-deficient (apoE-/-) mice before plaque development, and in C57Bl/6 mice.
  94. ncbi ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    Y Nakashima
    Department of Pathology, University of Washington, Seattle 98195
    Arterioscler Thromb 14:133-40. 1994
    ..Mice fed the Western-type diet generally had more advanced lesions than those fed a chow diet. The apoE-deficient mouse contains the entire spectrum of lesions observed during atherogenesis and is the first mouse model ..
  95. pmc Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility
    W Weng
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 93:14788-94. 1996
    ..The apo A-II deficiency trait was bred onto the atherosclerosis-prone apo E-deficient background, which resulted in a surprising 66% decrease in cholesterol levels due primarily to decreased ..
  96. ncbi Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
    K R Bales
    Nat Genet 17:263-4. 1997
  97. ncbi Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
    P Carmeliet
    Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Nat Genet 17:439-44. 1997
    ..Analysis of atherosclerotic aorta in mice with a deficiency of apoliprotein E (Apoe-/-; ref. 18), singly or combined with a deficiency of t-PA (Apoe-/-:Plat-/-) or of u-PA (Apoe-/-:Plau-/-; ref...
  98. ncbi Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice
    C L Ramos
    Departments of Biomedical Engineering and Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    Circ Res 84:1237-44. 1999
    b>Apolipoprotein E-deficient (ApoE-/-) mice develop atherosclerotic lesions throughout the arterial tree, including the carotid bifurcation...
  99. ncbi Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration
    M Buttini
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Neurosci 19:4867-80. 1999
    ..that apoE3, but not apoE4, protects against age-related and excitotoxin-induced neurodegeneration, we analyzed apoE knockout (Apoe-/-) mice expressing similar levels of human apoE3 or apoE4 in the brain under control of the neuron-..
  100. pmc Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
    K R Bales
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Proc Natl Acad Sci U S A 96:15233-8. 1999
    ..overexpressing the V717F human amyloid precursor protein (APP(V717F+/-) TG mice) with no, one, or two mouse apolipoprotein E (Apoe) alleles at various ages...
  101. pmc Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
    M Accad
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 105:711-9. 2000
    ..In the setting of severe hypercholesterolemia caused by deficiency in apoE or the LDL receptor (LDLR), total ACAT1 deficiency led to marked alterations in cholesterol homeostasis and ..

Research Grants63

  1. Interaction of ApoE with Estrogen in the Olfactory System
    Britto Nathan; Fiscal Year: 2008
    ..The hypothesis is that apolipoprotein E (apoE, a lipid transporting protein), is a critical intermediary for the beneficial effects of estrogens on ..
  2. APOE EFFECT ON CNS NEURONS--ROLE OF LRP
    David Holtzman; Fiscal Year: 2003
    DESCRIPTION (Applicant's Abstract): Genetic studies have shown that the E4 allele of apolipoprotein E (apoE) is a risk factor for Alzheimer's disease (AD)...
  3. CNS/plasma ABeta clearance of anti-ABeta antibody
    David Holtzman; Fiscal Year: 2003
    ..This will determine how anti-Abeta antibodies influence CNS/plasma Abeta transport exchanges. ..
  4. EFFECTS OF AGING & PGP ON AB EFFLUX FROM THE BRAIN
    ANNE FAGAN NIVEN; Fiscal Year: 2005
    ..Support for the hypothesis would establish a role for age-dependent defects in A-beta clearance from the brain in the pathogenesis of AD and, importantly, provide a novel therapeutic target for treatment of the disease. ..
  5. EXPERIMENTAL EMPHYSEMA--STUDIES ON REMEDIATION
    Donald Massaro; Fiscal Year: 2001
    ....
  6. REMEDIATION OF EMPHYSEMA--MECHANISMS, CHARACTERISTICS
    Donald Massaro; Fiscal Year: 2001
    ....
  7. Alveolar Biology: Sex, Age, and Alveolar Turnover
    Donald Massaro; Fiscal Year: 2007
    ..abstract_text> ..
  8. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  9. QTL analysis of carotid atherosclerosis
    Weibin Shi; Fiscal Year: 2007
    ..is to identify genetic factors that contribute to the development of carotid atherosclerosis, using the novel apolipoprotein E-deficient (apoE-/-) mouse model...
  10. APOE4 and Loss of Synaptic Integrity
    Patrick Sullivan; Fiscal Year: 2009
    ..Studies from our lab using a human apoE targeted replacement (TR) mouse model system provide supporting evidence for apoE's role in synaptic integrity...
  11. Genetic analysis of neointimal hyperplasia
    Weibin Shi; Fiscal Year: 2009
    ..On the apolipoprotein E-deficient (apoE-/-) background, inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) differ markedly in ..
  12. Regulation of atherosclerosis susceptibility.
    Weibin Shi; Fiscal Year: 2006
    ..On the apoE-deficient (apoE-/-) background, mouse strain C57BL/6J (B6) develops much larger atherosclerotic I lesions than ..
  13. Nanospheres as Vehicles for Treatment of Neuroblastoma
    Thomas Shea; Fiscal Year: 2004
    ..Resulting data will indicate whether or not nanospheres represent useful delivery agents for cancer therapy. ..
  14. Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
    MARK PERRELLA; Fiscal Year: 2008
    ..abstract_text> ..
  15. Long Term Cardiovascular Effects of Inhaled Nanoparticles
    Lung Chi Chen; Fiscal Year: 2008
    ..Preliminary studies have demonstrated that 6 months of 6-hr weekday exposures of mice lacking apolipoprotein E (ApoE-/-) to fine ambient concentrated particles enhanced atherosclerosis, and altered vasoconstrictor ..
  16. Role of APEG-1 in Vascular Smooth Muscle Biology
    MARK PERRELLA; Fiscal Year: 2005
    ..Furthermore, the identification of VSMC-specific promoters will be crucial for future use of gene therapy to direct foreign gene expression in the blood vessel wall. ..
  17. Diesel Exhaust and Atherosclerotic Plaque Stability
    Michael Rosenfeld; Fiscal Year: 2007
    ....
  18. ABCA1, ApoAI, and Lipid Efflux
    Jonathan Smith; Fiscal Year: 2008
    ..In addition, this study will include the identification of the apoAl oxidative modification by the enzyme myeloperoxidase that diminishes its lipid acceptor activity. ..
  19. Air Pollution Exposure/Atherosclerosis:Vascular Mechanism
    Sanjay Rajagopalan; Fiscal Year: 2007
    ..plays a fundamental role in the initiation and progression of atherosclerosis in a genetically susceptible model (Apo E-/-) through the activation of ROS dependent pathways...
  20. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani Subbaiah; Fiscal Year: 2008
    ..These studies will provide novel insights into the physiological role of this important phospholipid, and could possibly open up novel therapeutic targets against inflammation and atherosclerosis. ..
  21. HORMONE REPLACEMENT FOR PREVENTION OF VISCERAL OBESITY
    William Cefalu; Fiscal Year: 2002
    ....
  22. 2007 Atherosclerosis Gordon Research Conference
    Michael Rosenfeld; Fiscal Year: 2007
    ..The [unreadable] conference will provide a comprehensive overview of current research on [unreadable] atherosclerosis with a focus on the latest and most exciting developments in the field. [unreadable] [unreadable] [unreadable]..
  23. Combinatorial Protein Transfer for Cancer Therapeutics
    Aoshuang Chen; Fiscal Year: 2006
    ..abstract_text> ..
  24. Chromium, Cellular Energy Status and Whole Body Energy Balance
    William Cefalu; Fiscal Year: 2007
    ..abstract_text> ..
  25. Is S-adenosyl Methionine a Nutrition: Genetic Link in AD?
    Thomas Shea; Fiscal Year: 2008
    ..b>ApoE-/- mice have reduced SAM regardless of diet, and folate-deficiency reduces SAM to critical levels, leading to ..
  26. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..Novel Intervention for Colitis The scope of the current proposal is to determine whether administration of an apoE mimetic peptide, COG112, improves clinical, histological and inflammatory outcomes in clinically relevant paradigms ..
  27. The Role of Oxidative Stress in Endothelial Aging
    Hong Yang; Fiscal Year: 2008
    ..Such information is important for understanding the role of ROS in the age-related development of atherosclerosis and could lead to potential strategies of therapy for atherosclerosis. ..
  28. ID3 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION
    Coleen McNamara; Fiscal Year: 2008
    ..abstract_text> ..
  29. MACROPHAGE EXPRESSION OF APOAI AND ATHEROSCLEROSIS
    Sergio Fazio; Fiscal Year: 2008
    ..We have also shown that arterial expression of apoAl significantly reduces the atherogenesis induced by apoE deficiency, suggesting that macrophage apoAl can counter heavy lipid burden...
  30. Intermediate Filaments 2008 Gordon Research Conference
    Thomas Shea; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    Joachim Herz; Fiscal Year: 2009
    ..During the first funding period we showed that the very-low-density lipoprotein receptor (VLDLR) and the Apolipoprotein E receptor-2 (ApoER2) function not only as transporters for cholesterol and other lipids, but also as ..
  32. Testing Human Quantitative Genomic Variations in Mice
    Nobuyo Maeda; Fiscal Year: 2009
    ..The "low-high" strains of mice that we produce should aid in distinguishing between local and systemic effects of gene expression and allow further dissection of the underlying molecular mechanisms. ..
  33. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2010
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  34. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..and circulating levels of a specific IgM to oxPL correlating with an increase in atherosclerosis fomnation in ApoE-1 - mice null for the Id3 gene compared with ApoE-I- controls...
  35. Invasive Bacteria Accelerate Atherosclerosis through TLRs
    Caroline A Genco; Fiscal Year: 2010
    ..gingivalis in an apoE model of atherosclerosis...
  36. Novel Immunological Modifer as a Tissue Protector
    MICHAEL VITEK; Fiscal Year: 2006
    ..Several reports in the literature have shown that mice lacking the APOE gene (APOE knockout mice) and therefore lacking apolipoprotein-E (apoE protein), are more susceptible to death ..
  37. HOMOCYSTEINE, INFLAMMATION, AND ATHEROGENESIS
    Michael Rosenfeld; Fiscal Year: 2001
    ..Under Aim 2, the investigator will determine the mechanism by which HC and lipid accumulation alter glutathione and NADH/NADPH metabolism, thereby activating macrophages in vitro. ..
  38. APOPROTEIN E AND NEURITE OUTGROWTH
    GODFREY GETZ; Fiscal Year: 2001
    ..ApoE4, a less prevalent isoform of apoE, does not share these properties of apoE3...
  39. VASCULAR SMOOTH MUSCLE GROWTH AND FIBRONECTIN MATRIX
    GODFREY GETZ; Fiscal Year: 2002
    ..By understanding the role of the ECM in pathological processes such as restenosis and atherosclerosis we may begin to design more effective treatments for these conditions. ..
  40. GINGIPAIN R1 PEPTIDES FOR ORAL IMMUNIZATION
    Caroline Genco; Fiscal Year: 2002
    ..gingivalis induced periodontal destruction. ..
  41. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  42. BIOCHEMISTRY/BIOLOGY OF 5-LIPOXYGENASE AND LEUKOTRIENES
    COLIN FUNK; Fiscal Year: 2003
    ..New insights into the pathophysiologic sequelae of leukotrienes in asthma and ultimately better treatments of this disease will be an outcome of these studies. ..
  43. Mechanisms of Pro-Thrombosis in Diabetes Mellitus
    David Schneider; Fiscal Year: 2003
    ..Further, these results will define the importance of prothrombotic potential in diabetic subjects while potentially identifying new therapeutic targets in patients with diabetes and other insulin resistant states. ..
  44. HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEA
    Andrew Levy; Fiscal Year: 2003
    ....
  45. Selective Uptake from LDL:Role of the Plasma Membrane
    Toru Seo; Fiscal Year: 2004
    ..Roles of SU and its regulation by FC and FFA will be delineated and results from these studies will provide further understanding on mechanisms of cholesterol delivery to cells...
  46. NOVEL INHIBITORS OF BRAIN ISCHEMIA
    MICHAEL VITEK; Fiscal Year: 2003
    ..In Phase I, we will measure the effect of treatment with synthetic KPI domain to reduce fibrin deposition and improve behavioral performance in a mouse model for focal ischemic injury. ..
  47. THE ROLE OF PLASMA SPHINGOMYELIN IN ATHEROSCLEROSIS
    Xian Cheng Jiang; Fiscal Year: 2004
    ..We found that hepatic SPT activity in apolipoprotein E-deficient mice (apoE KO), a mouse model of atherosclerosis, was increased two fold over that in wild type (Wt)..
  48. Angiotensin/Sympathetic Interactions and Blood Pressure
    Lisa Cassis; Fiscal Year: 2004
    ..Moreover, novel interactions between AngII and leptin in the control of blood pressure may relate to hypertension in the obese population. ..
  49. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....
  50. LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIES
    Papasani Subbaiah; Fiscal Year: 2002
    ..These studies should provide novel insights into the physiological importance of LCAT beyond its role in cholesterol esterification. ..
  51. Inflammation, Procoagulation, and Plaque Vulnerability
    Burton Sobel; Fiscal Year: 2005
    ..abstract_text> ..
  52. CNS Stem Cells for Alzheimer's Disease Therapy
    George Carlson; Fiscal Year: 2005
    ..The objectives of this grant are to test human neural stern cells as candidate therapeutics for the treatment of Alzheimer's disease. ..
  53. APO E Receptors and Modulation of Fast Axonal Transport
    Joachim Herz; Fiscal Year: 2006
    ..of embryonic neurons as well as on neurons in the mature brain, where they can also function as receptors for Apolipoprotein E (ApoE). ApoE exists in three major isoforms...
  54. Triple Transgenic Model of Alzheimer's Disease
    MICHAEL VITEK; Fiscal Year: 2006
    ..This triple transgenic mouse (APP + TAU + APOE) is designed to display both neurofibrilary tangles and amyloid plaques in their brains...
  55. ATHEROSCLEROSIS PREVENTION IN MICE BY MUTANT APO A-1
    GODFREY GETZ; Fiscal Year: 2001
    ..and progression to fibroproliferative lesions) and to promote regression of lesions that spontaneously develop in apoE deficient mice...
  56. Chromium and Insulin Action
    William Cefalu; Fiscal Year: 2006
    ..abstract_text> ..
  57. Androgens and apoE4 induced cognitive impairments
    Jacob Raber; Fiscal Year: 2005
    ..ApoE4 interacts with female gender, resulting in an even greater risk of developing AD. Understanding apoE-gender interactions is important for developing AD treatments...
  58. Regulatory T cells in Systemic Lupus Erythematosus
    Harini Bagavant; Fiscal Year: 2007
    ..This award will help to overcome the lag period in my career induced by my leave of absence and return to a new field of study, and will facilitate my aim of becoming an independent scientist. ..
  59. CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGY
    Trudy Forte; Fiscal Year: 2004
    ..abstract_text> ..
  60. IMPROVED ASSAYS FOR SPECIFICALLY MEASURING COLLAGENASE-3
    MICHAEL VITEK; Fiscal Year: 2004
    ..This "assay" kit can then be used in arthritis and cancer by assessing disease progression. ..
  61. Novel Intervention for Amyloid-Induced Neuroinflammation
    MICHAEL VITEK; Fiscal Year: 2007
    ..is to test the efficacy of a potent anti-inflammatory compound, COG133, which is a novel peptide fragment of apolipoprotein E, for its ability to modulate microvascular amyloid, neuroinflammation and behavioral performance in these ..