Apoa1

Summary

Gene Symbol: Apoa1
Description: apolipoprotein A-I
Alias: Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2, apo-AI, apoA-I, apolipoprotein A-I, apolipoprotein A1
Species: mouse

Top Publications

  1. ncbi ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes
    A S Plump
    Laboratory of Biochemical, Genetics, and Metabolism, Rockefeller University, New York, NY 10021, USA
    J Lipid Res 38:1033-47. 1997
  2. ncbi Evidence for differential effects of apoE3 and apoE4 on HDL metabolism
    Paul C R Hopkins
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141 9100, USA
    J Lipid Res 43:1881-9. 2002
  3. pmc Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung
    Weiling Wang
    Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 51:2560-70. 2010
  4. doi Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Arterioscler Thromb Vasc Biol 28:925-31. 2008
  5. pmc Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3
    Ali G Gharavi
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:2488-93. 2004
  6. ncbi Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 271:7551-8. 1996
  7. ncbi The acute phase response in apolipoprotein A-1 knockout mice: apolipoprotein serum amyloid A and lipid distribution in plasma high density lipoproteins
    T Hajri
    Edith Nourse Rogers Memorial Veterans Administration Hospital, Bedford, MA 01730, USA
    Biochim Biophys Acta 1394:209-18. 1998
  8. pmc An essential role in liver development for transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 USA
    Genes Dev 14:152-7. 2000
  9. doi Coexpression of CLA-1 and human PDZK1 in murine liver modulates HDL cholesterol metabolism
    Hidenori Komori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:1298-303. 2008
  10. ncbi Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice
    H Li
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Arterioscler Thromb 13:1814-21. 1993

Research Grants

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes
    A S Plump
    Laboratory of Biochemical, Genetics, and Metabolism, Rockefeller University, New York, NY 10021, USA
    J Lipid Res 38:1033-47. 1997
    ..In the apoA-I knockout mouse model it appears that low HDL levels create a new steady state in which decreased cholesterol is delivered to both peripheral tissues and the liver...
  2. ncbi Evidence for differential effects of apoE3 and apoE4 on HDL metabolism
    Paul C R Hopkins
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141 9100, USA
    J Lipid Res 43:1881-9. 2002
    ....
  3. pmc Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung
    Weiling Wang
    Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 51:2560-70. 2010
    ..These data demonstrate that apoA-I plays important roles in limiting pulmonary inflammation and oxidative stress, which if not prevented, will decrease pulmonary artery vasodilatation and increase airway hyperresponsiveness...
  4. doi Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Arterioscler Thromb Vasc Biol 28:925-31. 2008
    ....
  5. pmc Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3
    Ali G Gharavi
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:2488-93. 2004
    ..These findings demonstrate a strong genetic influence on HIVAN and demonstrate a major renal disease susceptibility locus on mouse chromosome 3A1-3...
  6. ncbi Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 271:7551-8. 1996
    ..The identification and cloning of two functional murine chemokine receptors provides important new tools for investigating the roles of these potent cytokines in vivo...
  7. ncbi The acute phase response in apolipoprotein A-1 knockout mice: apolipoprotein serum amyloid A and lipid distribution in plasma high density lipoproteins
    T Hajri
    Edith Nourse Rogers Memorial Veterans Administration Hospital, Bedford, MA 01730, USA
    Biochim Biophys Acta 1394:209-18. 1998
    ..a positive acute phase reactant protein, is transported in high density lipoproteins (HDL), especially HDLH (apoA1-rich HDL)...
  8. pmc An essential role in liver development for transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 USA
    Genes Dev 14:152-7. 2000
    ..Therefore, XBP-1 is a transcription factor essential for hepatocyte growth...
  9. doi Coexpression of CLA-1 and human PDZK1 in murine liver modulates HDL cholesterol metabolism
    Hidenori Komori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:1298-303. 2008
    ..This study was aimed to clarify the role of the human SR-BI/CD36 and LIMP-II Analogues-1 (CLA-1) as a molecular target of selective uptake of cholesteryl ester from HDL in vivo...
  10. ncbi Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice
    H Li
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Arterioscler Thromb 13:1814-21. 1993
    ..Inbred strain 129 mice homozygous for the inactive Apoa1 gene and maintained on regular mouse chow had markedly reduced total cholesterol (26% normal) and high-density ..
  11. ncbi ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice
    E Voyiaziakis
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 39:313-21. 1998
    ..This mouse model mimics human conditions associated with low HDL levels and provides additional evidence for the anti-atherogenic role of apoA-I...
  12. ncbi Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile
    Y Ji
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:33398-402. 1999
    ..Thus, in the mouse, a major portion of the clearance of HDL FC from plasma is mediated by SR-BI...
  13. ncbi Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution
    Erica J Reschly
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:9645-54. 2002
    ..Human apoA-I self-associates more and activates human lecithin-cholesterol acyltransferase better than mouse apoA-I. These differential characteristics of human and mouse apoA-I are not dependent on helices 7/8...
  14. ncbi Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I
    Laurent O Martinez
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:37368-74. 2003
    ....
  15. ncbi Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro
    Veneracion G Cabana
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Lipid Res 45:317-25. 2004
    ..In the absence of both apoA-I and apoE, SAA-HDL is not formed and SAA associates with any available lipoprotein...
  16. ncbi Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation
    Ryan E Moore
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circ Res 97:763-71. 2005
    ....
  17. ncbi Phases of canonical Wnt signaling during the development of mouse intestinal epithelium
    Byeong Moo Kim
    Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 133:529-38. 2007
    ..Because mutations in Wnt pathway genes lead to intestinal cancer, the role of Wnt signaling in gut epithelial homeostasis is a subject of intense investigation. We studied how Wnt signaling is established during intestine development...
  18. ncbi Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BI
    Iris Lorenzi
    Institute of Clinical Chemistry and Center for Integrative Human Biology, University of Zurich, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    J Mol Med (Berl) 86:171-83. 2008
    ..Furthermore, blocking apoA-I uptake inhibits cholesterol efflux to apoA-I but not to HDL. Taken together, these data suggest that apoA-I- but not HDL-mediated cholesterol efflux may involve retroendocytosis...
  19. doi Influence of tertiary structure domain properties on the functionality of apolipoprotein A-I
    Masafumi Tanaka
    Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe 658 8558, Japan
    Biochemistry 47:2172-80. 2008
    ..It is clear that the stability of the N-terminal helix bundle, and the hydrophobicity and alpha-helix content of the C-terminal domain, are critical factors in determining the overall properties of the apoA-I molecule...
  20. pmc ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments
    Maxime Denis
    Ottawa Health Research Institute, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 283:16178-86. 2008
    ..We therefore conclude that the plasma membrane is the main platform where ABCA1-mediated lipidation of apoA-I occurs...
  21. pmc Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I
    Mao Koyama
    Department of Biophysical Chemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakitamachi, Higashinada ku, Kobe 658 8558, Japan
    Biochemistry 48:2529-37. 2009
    ..Taken together, these results suggest that interaction between the N- and C-terminal tertiary structure domains in apoA-I modulates the stability and lipid-binding properties of the N-terminal helix bundle...
  22. pmc Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles
    Sissel Lund-Katz
    Lipid Research Group, Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Lipid Res 51:606-17. 2010
    ..This K(d) value does not apply to all of the apoA-I molecules on the HDL particle but only to a relatively small, labile pool...
  23. doi Cysteinemia, rather than homocysteinemia, is associated with plasma apolipoprotein A-I levels in hyperhomocysteinemia: lipid metabolism in cystathionine beta-synthase deficiency
    Mario Nuño-Ayala
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Instituto Aragones de Ciencias de la Salud, Universidad de Zaragoza Salud del Gobierno de Aragon, Spain
    Atherosclerosis 212:268-73. 2010
    Genetic and dietary hyperhomocysteinemia has been found to decrease high density lipoproteins (HDL) and their apolipoprotein A1 (APOA1)...
  24. pmc ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis
    Yaoyong Wang
    Department of Aging Biology, Institute on Aging and Adaptation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan
    J Lipid Res 52:1461-70. 2011
    ..To study the influence of apoA-I on apoA-II and AApoAII amyloidosis, apoA-I-deficient (C57BL/6J.Apoa1⁻/⁻) mice were used...
  25. pmc Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein
    Timothy J Sontag
    Department of Pathology, University of Chicago, Chicago, IL, USA
    J Lipid Res 53:951-63. 2012
    ....
  26. pmc The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects
    Maryam Zamanian-Daryoush
    Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 288:21237-52. 2013
    Here, we show that apolipoprotein A1 (apoA1), the major protein component of high density lipoprotein (HDL), through both innate and adaptive immune processes, potently suppresses tumor growth and metastasis in multiple animal tumor ..
  27. doi Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipids
    Pierre R Provost
    Laboratory of Ontogeny and Reproduction, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Quebec, Canada
    J Endocrinol 200:321-30. 2009
    ..Our results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis...
  28. pmc Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein
    Junji Watanabe
    Atherosclerosis Research Unit, Department of Medicine Cardiology, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:18292-301. 2009
    ..Our data strongly suggest that HDL can become proinflammatory via the Hb x Hp pathway in mice and humans, and dissociation of Hb x Hp x Hx complexes from apoA-1-containing particles of HDL may be a novel target for the treatment of CHD...
  29. pmc Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses
    E M Rubin
    Division of Research Medicine and Radiation Biophysics, Lawrence Berkeley Laboratory, University of California, Berkeley 94720
    Proc Natl Acad Sci U S A 88:434-8. 1991
    ..These results suggest a dominant role of apoAI in determining the HDL particle size distribution and a mechanism involving expression of human apoAI transgenes that alters the plasma levels of mouse apoAI...
  30. ncbi Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresis
    L S Ramagli
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
    Biochem Genet 28:123-36. 1990
    ..These 16 NHCP genetic marker inheritance differences detected in RIs add to the 23 previously established genetic marker differences between the progenitors...
  31. ncbi Selection of a gene for apolipoprotein A1 using autoantibodies from a patient with systemic lupus erythematosus
    J T Merrill
    St Lukes Roosevelt Hospital Center, Division of Rheumatology, New York, NY 10019, USA
    Arthritis Rheum 38:1655-9. 1995
    To investigate immunoreactivity of systemic lupus erythematosus (SLE) sera with apolipoprotein A1, (Apo A1), the major lipid-binding protein of high-density lipoprotein (HDL).
  32. ncbi Developmental changes in methylation of spermatogenesis-specific genes include reprogramming in the epididymis
    M Ariel
    Department of Cellular Biochemistry, Hebrew University, Medical School, Jerusalem, Israel
    Nat Genet 7:59-63. 1994
    We have determined the status of DNA methylation at specific sites in three spermatogenesis-specific genes, Pgk-2, ApoA1 and Oct-3/4, throughout the development and differentiation of male germ cells in the mouse...
  33. pmc Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice
    O Stein
    Department of Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 94:9820-4. 1997
    ..These results provide support for the thesis that anti-atherogenicity of high density lipoprotein is related in part to its role in cholesterol removal...
  34. ncbi Repetitive elements in the third intron of murine apolipoprotein A-I gene
    A N Chiang
    Institute of Biochemistry, School of Life Science, National Yang Ming University, Taipei, Taiwan
    Biochem Mol Biol Int 43:989-96. 1997
    ..These repetitive motifs are very similar to the sequences flanking human Alu and rodent B1 repetitive elements, although no evidence for the existence of Alu or B1 was found near the peculiar repetitive DNA sequences in apoA-I gene...
  35. ncbi Kinetic characteristics and regulation of HDL cholesteryl ester and apolipoprotein transport in the apoA-I-/- mouse
    D K Spady
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 75235, USA
    J Lipid Res 39:1483-92. 1998
    ..HDL cholesteryl ester transporter activity and scavenger receptor type B1 (SR-BI) protein and mRNA levels were not up-regulated in any organ of apoA-I-/- mice even though these animals lack normal HDL...
  36. pmc GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo
    E E Morrisey
    Department of Medicine, University of Chicago, Chicago, Illinois 60637 USA
    Genes Dev 12:3579-90. 1998
    ..In addition, these data demonstrate that GATA6 is required for establishment of the endodermally derived bronchial epithelium...
  37. ncbi On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway
    Maki Tsujita
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    J Lipid Res 46:154-62. 2005
    ..We conclude that the main mechanism for HDL assembly by endogenous apoA-I in HepG2 cells is an autocrine-like reaction in which apoA-I is secreted and then interacts with cellular ABCA1 to generate HDL...
  38. ncbi Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1
    Ken Kitajima
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania Medical Center, 654 BRBII III Labs, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Atherosclerosis 186:65-73. 2006
    ..Furthermore, AAV1-based vectors generate higher apoA-l levels than AAV5-based vectors. It is possible that the levels of expression achieved using these vectors will be therapeutic in preventing atherosclerosis...
  39. ncbi Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis
    Shmuel Mandel
    Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    Dev Biol 303:814-24. 2007
    ..These results place ADNP at a crucial point of gene regulation, repressing potential endoderm genes and enhancing genes associated with organogenesis/neurogenesis...
  40. ncbi LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN
    Georgios Koukos
    Molecular Genetics, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 46:10713-21. 2007
    ..Both defects can be corrected by treatment with LCAT...
  41. ncbi Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiency
    David T Valenta
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Lipid Res 49:24-32. 2008
    ..Thus, unlike total systemic PLTP, locally produced macrophage-derived PLTP beneficially alters lipoprotein metabolism and reduces lesion progression in hyperlipidemic mice...
  42. pmc Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice
    Pin Yue
    Department of Medicine, Washington University School of Medicine, Center for Human Nutrition, St Louis, Missouri, United States of America
    PLoS ONE 5:e9906. 2010
    ..In conclusion, CD36 influences reverse cholesterol transport and hepatic ApoA-I production. Both pathways are enhanced in CD36 deficiency, increasing HDL concentrations, which suggests the potential benefit of CD36 inhibition...
  43. doi APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans
    Tomoko Inoue
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Stem Cell Rev 7:43-52. 2011
    ..Moreover, APOA-1 gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans...
  44. doi Enhanced binding of apolipoprotein A-I variants associated with hypertriglyceridemia to triglyceride-rich particles
    Irina N Gorshkova
    Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, Massachusetts 02118, United States
    Biochemistry 50:2040-7. 2011
    ..While many factors may be involved in induction of HTG, we suggest that an increased level of association of destabilized loosely folded apolipoproteins with TG-rich lipoproteins may contribute to some cases of HTG in humans...
  45. pmc HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells
    Jonathan E Feig
    The Leon H Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 108:7166-71. 2011
    ..Overall, these results establish HDL as a regulator in vivo of the migratory and inflammatory properties of monocyte-derived cells in mouse atherosclerotic plaques, and highlight the phenotypic plasticity of these cells...
  46. doi Reduced biliary sterol output with no change in total faecal excretion in mice expressing a human apolipoprotein A-I variant
    Cinzia Parolini
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy
    Liver Int 32:1363-71. 2012
    ....
  47. pmc Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity
    Jennifer H Madenspacher
    Laboratory of Respiratory Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 287:43730-40. 2012
    ....
  48. pmc Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDL
    Panagiotis Fotakis
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118
    J Lipid Res 54:3281-92. 2013
    ..Alterations of the charged 223, 226 residues caused milder but discrete changes in HDL phenotype...
  49. pmc High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice
    Maarit Lehti
    Diabetes Research Department IDO and IDR, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, München Neuherberg, Germany M L, M K, T O, C S, S C, P T P, S M H Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH M L, E D, W A, O A M, K M H, J W, C R, J M, S S, C T, R K, S M G, R A G D S, D D, W S D, S M H LIKES Research Center for Sport and Health Sciences, Jyvaskyla, Finland M L Energy Metabolism Laboratory ETH Zurich Swiss Federal Institute of Technology, Zurich, UNICAMP
    Circulation 128:2364-71. 2013
    ..We used genetic mouse models with increased HDL levels (apolipoprotein A-I transgenic [apoA-I tg]) and reduced HDL levels (apoA-I-deficient [apoA-I ko]) to investigate whether HDL modulates mitochondrial bioenergetics in skeletal muscle...
  50. pmc Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction
    Alisher R Dadabayev
    Department of Anesthesia, Cleveland Clinic, Cleveland, OH
    J Nutr 144:1030-6. 2014
    HDL and apolipoprotein A1 (apoA1) concentrations inversely correlate with risk of death from ischemic heart disease; however, the role of apoA1 in the myocardial response to ischemia has not been well defined...
  51. pmc Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice
    Leland L Black
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294
    J Immunol 195:4685-98. 2015
    ....
  52. ncbi [Mapping of apolipoprotein A-1 and ceruloplasmin genes on human, rat and mouse chromosomes by hybridization in situ with specific human DNA probes]
    V S Baranov
    Biull Eksp Biol Med 105:587-9. 1988
    ..Heterologous in situ hybridization of other species with DNA probes does not always give reliable results in gene mapping. Thus, the data of heterologous hybridization should be considered with caution...
  53. pmc ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice
    Andrew J Murphy
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 121:4138-49. 2011
    ..In contrast, Apoa1⁻/⁻ mice showed no monocytosis compared with controls...
  54. doi The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1
    Sophie Stukas
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    Biochim Biophys Acta 1821:536-46. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  55. doi Apolipoprotein A-I Helsinki promotes intracellular acyl-CoA cholesterol acyltransferase (ACAT) protein accumulation
    Juan D Toledo
    Facultad de Ciencias Medicas, Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, Universidad Nacional de La Plata, La Plata, Argentina
    Mol Cell Biochem 377:197-205. 2013
    ..Although a similar choline-phospholipid efflux is evoked by these apoA-I variants, the change in phosphatidylcholine/sphyngomyelin distribution produced by wild-type apoA-I is not observed with either ∆K107 or ∆K226...
  56. pmc High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide
    Masashi Suzuki
    Department of Medicine, University of Washington, Seattle, USA
    Circulation 122:1919-27. 2010
    ..High-density lipoprotein (HDL) protects the artery wall by removing cholesterol from lipid-laden macrophages. However, recent evidence suggests that HDL might also inhibit atherogenesis by combating inflammation...
  57. pmc Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice
    Léa Ritie
    INSERM, U682, Strasbourg, France Univ de Strasbourg, France
    PLoS ONE 7:e37710. 2012
    ..Thus deregulated adhesion to laminin-511 may be instrumental in diseases such as human pathologies of the gut where laminin-511 is abnormally expressed as it is shown here...
  58. pmc ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT
    Adelina Duka
    Molecular Genetics, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 54:107-15. 2013
    ....
  59. pmc Genome-wide screen for modulation of hepatic apolipoprotein A-I (ApoA-I) secretion
    Rebecca R Miles
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 288:6386-96. 2013
    ..In total, this work underscores the power of functional genetic assessment to identify new therapeutic targets...
  60. doi Reverse apolipoprotein A-I mimetic peptide R-D4F inhibits neointimal formation following carotid artery ligation in mice
    Lin Du
    Department of Cardiology, Second Clinic Medical College, Yangzhou University, Yangzhou, China
    Am J Pathol 182:1932-9. 2013
    ..Taken together, these results suggest that R-D4F has significant anti-inflammatory features and facilitates prevention of neointimal formation after vascular injury in mice...
  61. pmc High density lipoprotein protects against polymicrobe-induced sepsis in mice
    Ling Guo
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 288:17947-53. 2013
    ..Our study supports efforts to raise HDL levels as a therapeutic approach for sepsis. ..
  62. pmc Use of two-dimensional electrophoresis to identify and map new mouse genes
    R W Elliott
    Genetics 91:295-308. 1979
    ..These eight genes will be useful reference markers in future crosses designed to map new genes...
  63. ncbi Gene for a serum protein on chromosome 9 in the mouse
    E M Håkansson
    Genet Res 33:147-52. 1979
  64. pmc Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I
    R Williamson
    Department of Pathology and Curriculum in Genetics, University of North Carolina, Chapel Hill 27599 7525
    Proc Natl Acad Sci U S A 89:7134-8. 1992
    ....
  65. ncbi Dietary fatty acids and dietary cholesterol differ in their effect on the in vivo regulation of apolipoprotein A-I and A-II gene expression in inbred strains of mice
    R A Srivastava
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 68110
    Biochim Biophys Acta 1125:251-61. 1992
    ..This study identifies potential loci of regulation and forms the basis for future studies investigating specific genetic and molecular regulatory mechanisms...
  66. ncbi Structure of the murine gene encoding apolipoprotein A-I
    T P Boyle
    Upjohn Laboratories, Kalamazoo, MI 49007
    Gene 117:243-7. 1992
    ..4). Kyte-Doolittle analyses of the three proteins indicate that there is no significant difference in the structure of these apolipoproteins...
  67. ncbi Structure, expression and chromosomal location of the Oct-4 gene
    Y I Yeom
    Department of Zoology, University of Texas, Austin
    Mech Dev 35:171-9. 1991
    ..By in situ hybridization, detectable onset of zygotic Oct-4 expression does not occur until compaction begins at 8-cells, suggesting that there might be other regulatory factors responsible for initiating Oct-4 expression...
  68. pmc Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice
    B Paigen
    Children s Hospital Oakland Research Institute, Children s Hospital Medical Center, Oakland 94609
    Genetics 122:163-8. 1989
    ..Recombinant inbred strains derived from C57BL/6 and A were characterized for Apoa 1, Apoa 2 and susceptibility to atherosclerosis...
  69. ncbi Genetic mapping of mouse T3d and T3e between Apoa1 and Ncam
    R D Miller
    Division of Molecular Biology, Medical Biological Institute, La Jolla, CA 92037
    Immunogenetics 30:511-4. 1989
  70. ncbi Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks
    M Prochazka
    Jackson Laboratory, Bar Harbor, ME 04609
    Diabetes 38:1446-55. 1989
    ..abstract truncated at 400 words)..
  71. ncbi The structural genes encoding P450scc and P450arom are closely linked on mouse chromosome 9
    G L Youngblood
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0278
    Endocrinology 125:2784-6. 1989
    ..The information presented in this report, along with other studies, indicate conservation between homologous human and mouse chromosomal regions and suggest that human P450SCC will be found to be closely linked with human P450arom...
  72. ncbi Fourteen genetically variant proteins of mouse brain: discovery of two new variants and chromosomal mapping of four loci
    D Goldman
    Biochem Genet 24:183-94. 1986
    ..In addition to these 13 genetically variant polypeptides, the positions of 12 other polypeptides which have been identified on 2DE gels of mouse brain are given...
  73. ncbi Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity
    A Scanu
    Biochemistry 8:3309-16. 1969
  74. ncbi Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor
    J H Russell
    Immunogenetics 14:263-72. 1981
    ..The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes...
  75. ncbi Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma
    J S Parks
    Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
    J Lipid Res 36:349-55. 1995
    ..abstract truncated at 250 words)..
  76. ncbi Nucleotide sequence of mouse spermidine synthase cDNA
    S Myöhänen
    Department of Biochemistry and Biotechnology, University of Kuopio, Finland
    DNA Seq 4:343-6. 1994
    ..The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E. coli spermidine synthase. The 3' flanking region contained an unusual polyadenylation signal AATACA...
  77. ncbi Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase
    C H Warden
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles, 90024
    J Lipid Res 34:1451-5. 1993
    ..Comparison of chromosomal locations for these genes in mouse and humans shows that the previously observed interspecies syntenies are preserved...
  78. pmc Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    H Shimano
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Clin Invest 98:1575-84. 1996
    ..The amount of white adipose tissue decreased progressively as the liver enlarged. These studies indicate that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver...
  79. ncbi Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice
    N R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536, USA
    J Lipid Res 38:1583-90. 1997
    ..We conclude that SAA is unable to substitute for apoA-I in HDL particle formation...
  80. ncbi ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages
    W A Boisvert
    Scripps Research Institute, Departments of Immunology, and Vascular Biology, La Jolla, CA, USA
    Arterioscler Thromb Vasc Biol 19:525-30. 1999
    Along with apolipoprotein (apo) E, which promotes cholesterol efflux from foam cells, apoA1-containing high density lipoprotein (HDL) is thought to facilitate the transport of cholesterol from lesions...
  81. ncbi Human growth hormone increases apo(a) expression in transgenic mice
    R Tao
    Departments of Internal Medicine and Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Arterioscler Thromb Vasc Biol 19:2439-47. 1999
    ..The coordinate changes in apo(a) mRNA and plasma levels of apo(a) in response to rhGH and IGF-1 strongly suggest that these 2 hormones have independent effects on the transcription of the apo(a) gene...
  82. ncbi The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas
    A E Allen-Jennings
    Department of Molecular and Cellular Biochemistry, Ohio State Biochemistry Program, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 276:29507-14. 2001
    ..Because ATF3 is a stress-inducible gene, these mice may represent a model to investigate the molecular mechanisms for some stress-associated diseases...
  83. ncbi Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I
    Mirko Ritter
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    Genomics 79:693-702. 2002
    ..The stimulation of cells derived from the kidney proximal tubules with apoA-I or HDL induces a concentration-dependent secretion of AI-BP indicating an important role for AI-BP, in the renal tubular degradation or resorption of apoA-I...
  84. ncbi Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake
    Ryan E Temel
    Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 277:26565-72. 2002
    ..The reduced V(max) for HDL CE-selective uptake likely contributes to the severe reduction in CE accumulation in steroidogenic cells of apoA-I(-/-) mice...
  85. ncbi Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux
    Miriam Lee
    Wihuri Research Institute, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 22:1475-81. 2002
    ....
  86. ncbi The roles of circulating high-density lipoproteins and trophic hormones in the phenotype of knockout mice lacking the steroidogenic acute regulatory protein
    Tomohiro Ishii
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 16:2297-309. 2002
    ....
  87. pmc A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I
    Nan Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 111:99-107. 2003
    ..Inhibition of ABCA1 degradation by calpain could represent a novel therapeutic approach to increasing macrophage cholesterol efflux and decreasing atherosclerosis...
  88. ncbi Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1
    Omar L Francone
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Biochemistry 42:8569-78. 2003
    ..Taken together, these observations suggest that ABCA1 is necessary for the adequate lipidation of apoAI, which enables the interaction with LCAT and subsequent maturation...
  89. ncbi Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles
    Lijuan Liu
    Gastrointestinal Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 278:42976-84. 2003
    ..This is consistent with lipid raft and non-raft plasma membrane domains being involved primarily in ABCA1-mediated vesicle release and nascent HDL formation, respectively...
  90. pmc Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol
    Manal Zabalawi
    Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Pathol 163:1201-13. 2003
    ....
  91. ncbi Potential involvement of dissociated apoA-I in the ABCA1-dependent cellular lipid release by HDL
    Kei ichiro Okuhira
    Biochemistry, Cell Biology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Lipid Res 45:645-52. 2004
    ..The data implicated that the ABCA1-dependent cholesterol release to HDL is mediated by apoA-I dissociated from HDL...
  92. ncbi Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice
    Jun ichi Suto
    Department of Molecular Biology and Immunology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8602, Japan
    Biochem Genet 41:325-41. 2003
    ..Identification of distinct, but related traits in an identical chromosomal region will facilitate revealing the responsible gene...
  93. pmc Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases
    Liqiang Tou
    Department of Medical Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Mol Cell Biol 24:3132-9. 2004
    ..Thus, modulation of endogenous class I HDAC levels represents a previously unappreciated mechanism to enable onset of tissue-restricted gene expression in a developing mammalian organ...
  94. ncbi Role of apolipoprotein A-I in protecting against endotoxin toxicity
    Juan Ma
    Department of Biochemistry, School of Pharmacy, Fudan University, Shanghai 200032, China
    Acta Biochim Biophys Sin (Shanghai) 36:419-24. 2004
    ..35 +/- 3.70) (P<0.01). The results suggest that: (1) ApoA-I has the ability to bind with and protect against LPS; (2) LFF enhances the effect of ApoA-I; (3) ApoA-I is the major contributor for HDL anti-endotoxin function...
  95. ncbi Remodeling of HDL remnants generated by scavenger receptor class B type I
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
    J Lipid Res 45:1666-73. 2004
    ..We conclude that HDL remnants, generated by SR-BI, are converted to larger particles by rapidly reassociating with existing HDL particles in an enzyme-independent manner...
  96. ncbi Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
    Veronica Hirsch-Reinshagen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver V5Z 4H4, Canada
    J Biol Chem 279:41197-207. 2004
    ..Additionally, the effect of ABCA1 on apoE is selective, as apoJ levels are unchanged in brains of ABCA1-/- mice. Taken together, these results show that glial ABCA1 is a key influence on apoE metabolism in the CNS...
  97. ncbi The expression of intact and mutant human apoAI/CIII/AIV/AV gene cluster in transgenic mice
    Jun Gao
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, People s Republic of China
    J Biol Chem 280:12559-66. 2005
    ....
  98. ncbi Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins
    Yue Zhao
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Biochemistry 44:1013-25. 2005
    ..We conclude that apoE is a more significant activator of LCAT than apoA-I on mouse apoB lipoproteins...
  99. ncbi Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I
    Marnie L Gruen
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Lipid Res 46:2007-14. 2005
    ..Moreover, the presence of large HDLs without apoA-I provides evidence for an apoA-I-independent pathway of cholesterol efflux, possibly sustained by apoE...
  100. ncbi Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model
    Cinzia Parolini
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Atherosclerosis 183:222-9. 2005
    ..685). Our data suggest that, in the atherosclerosis-susceptible human apoB/A-II mouse model, expression of the human apoA-I(M) gene does not have protective advantage over that of the apoA-I gene...
  101. ncbi Overexpression of human ApoAI transgene provides long-term atheroprotection in LDL receptor-deficient mice
    David T Valenta
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey, Pines Road, La Jolla, CA 92037, USA
    Atherosclerosis 189:255-63. 2006
    ..This was observed without a change in total HDL cholesterol levels. Thus, elevated levels of human apoAI in LDL receptor-deficient mice lacking mouse apoAI conferred profound protection against diet-induced over extended periods of time...

Research Grants12

  1. 2006 Lipoprotein Metabolism Gordon Conference
    MARY SORCI THOMAS; Fiscal Year: 2006
    ....
  2. APOLIPOPROTEIN VARIATION AND HUMAN DISEASE
    Vassilis Zannis; Fiscal Year: 2003
    ..Thus the information obtained from this project may provide rational approaches towards correcting low plasma HDL levels and reducing hypertriglyceridemia in humans. ..
  3. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  4. Group V Secretory Phospholipase A2 in Atherosclerosis
    Nancy Webb; Fiscal Year: 2007
    ..Measuring lesion size and cholesterol/cholesterol ester content will assess the extent of atherosclerosis. [unreadable] [unreadable]..
  5. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  6. EFFECTS OF AGING & PGP ON AB EFFLUX FROM THE BRAIN
    ANNE FAGAN NIVEN; Fiscal Year: 2005
    ..Support for the hypothesis would establish a role for age-dependent defects in A-beta clearance from the brain in the pathogenesis of AD and, importantly, provide a novel therapeutic target for treatment of the disease. ..
  7. Therapeutic potential-LXR ligands in Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2005
    ..abstract_text> ..
  8. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  10. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  11. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Functions of apoE in cholesterol and triglyceride homeostasis
    Vassilis I Zannis; Fiscal Year: 2010
    ..Gene transfer in single or double knockout mice for apoA-l, apoE, SR-BI and biochemical analyses will be employed in these studies. ..