Genomes and Genes
Gene Symbol: Apoa1
Description: apolipoprotein A-I
Alias: Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2, apo-AI, apoA-I, apolipoprotein A-I, apolipoprotein A1
Publications123 found, 100 shown here
- ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotesA S Plump
Laboratory of Biochemical, Genetics, and Metabolism, Rockefeller University, New York, NY 10021, USA
J Lipid Res 38:1033-47. 1997..In the apoA-I knockout mouse model it appears that low HDL levels create a new steady state in which decreased cholesterol is delivered to both peripheral tissues and the liver...
- Evidence for differential effects of apoE3 and apoE4 on HDL metabolismPaul C R Hopkins
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141 9100, USA
J Lipid Res 43:1881-9. 2002....
- Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lungWeiling Wang
Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
J Lipid Res 51:2560-70. 2010..These data demonstrate that apoA-I plays important roles in limiting pulmonary inflammation and oxidative stress, which if not prevented, will decrease pulmonary artery vasodilatation and increase airway hyperresponsiveness...
- Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cellsGiuseppe Danilo Norata
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
Arterioscler Thromb Vasc Biol 28:925-31. 2008....
- Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3Ali G Gharavi
Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 101:2488-93. 2004..These findings demonstrate a strong genetic influence on HIVAN and demonstrate a major renal disease susceptibility locus on mouse chromosome 3A1-3...
- Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9L Boring
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
J Biol Chem 271:7551-8. 1996..The identification and cloning of two functional murine chemokine receptors provides important new tools for investigating the roles of these potent cytokines in vivo...
- The acute phase response in apolipoprotein A-1 knockout mice: apolipoprotein serum amyloid A and lipid distribution in plasma high density lipoproteinsT Hajri
Edith Nourse Rogers Memorial Veterans Administration Hospital, Bedford, MA 01730, USA
Biochim Biophys Acta 1394:209-18. 1998..a positive acute phase reactant protein, is transported in high density lipoproteins (HDL), especially HDLH (apoA1-rich HDL)...
- An essential role in liver development for transcription factor XBP-1A M Reimold
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 USA
Genes Dev 14:152-7. 2000..Therefore, XBP-1 is a transcription factor essential for hepatocyte growth...
- Coexpression of CLA-1 and human PDZK1 in murine liver modulates HDL cholesterol metabolismHidenori Komori
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
Arterioscler Thromb Vasc Biol 28:1298-303. 2008..This study was aimed to clarify the role of the human SR-BI/CD36 and LIMP-II Analogues-1 (CLA-1) as a molecular target of selective uptake of cholesteryl ester from HDL in vivo...
- Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in miceH Li
Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
Arterioscler Thromb 13:1814-21. 1993..Inbred strain 129 mice homozygous for the inactive Apoa1 gene and maintained on regular mouse chow had markedly reduced total cholesterol (26% normal) and high-density ..
- ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic miceE Voyiaziakis
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Lipid Res 39:313-21. 1998..This mouse model mimics human conditions associated with low HDL levels and provides additional evidence for the anti-atherogenic role of apoA-I...
- Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bileY Ji
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
J Biol Chem 274:33398-402. 1999..Thus, in the mouse, a major portion of the clearance of HDL FC from plasma is mediated by SR-BI...
- Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distributionErica J Reschly
Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 277:9645-54. 2002..Human apoA-I self-associates more and activates human lecithin-cholesterol acyltransferase better than mouse apoA-I. These differential characteristics of human and mouse apoA-I are not dependent on helices 7/8...
- Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-ILaurent O Martinez
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
J Biol Chem 278:37368-74. 2003....
- Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitroVeneracion G Cabana
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
J Lipid Res 45:317-25. 2004..In the absence of both apoA-I and apoE, SAA-HDL is not formed and SAA associates with any available lipoprotein...
- Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammationRyan E Moore
Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Circ Res 97:763-71. 2005....
- Phases of canonical Wnt signaling during the development of mouse intestinal epitheliumByeong Moo Kim
Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Gastroenterology 133:529-38. 2007..Because mutations in Wnt pathway genes lead to intestinal cancer, the role of Wnt signaling in gut epithelial homeostasis is a subject of intense investigation. We studied how Wnt signaling is established during intestine development...
- Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BIIris Lorenzi
Institute of Clinical Chemistry and Center for Integrative Human Biology, University of Zurich, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
J Mol Med (Berl) 86:171-83. 2008..Furthermore, blocking apoA-I uptake inhibits cholesterol efflux to apoA-I but not to HDL. Taken together, these data suggest that apoA-I- but not HDL-mediated cholesterol efflux may involve retroendocytosis...
- Influence of tertiary structure domain properties on the functionality of apolipoprotein A-IMasafumi Tanaka
Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe 658 8558, Japan
Biochemistry 47:2172-80. 2008..It is clear that the stability of the N-terminal helix bundle, and the hydrophobicity and alpha-helix content of the C-terminal domain, are critical factors in determining the overall properties of the apoA-I molecule...
- ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartmentsMaxime Denis
Ottawa Health Research Institute, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario K1Y 4E9, Canada
J Biol Chem 283:16178-86. 2008..We therefore conclude that the plasma membrane is the main platform where ABCA1-mediated lipidation of apoA-I occurs...
- Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-IMao Koyama
Department of Biophysical Chemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakitamachi, Higashinada ku, Kobe 658 8558, Japan
Biochemistry 48:2529-37. 2009..Taken together, these results suggest that interaction between the N- and C-terminal tertiary structure domains in apoA-I modulates the stability and lipid-binding properties of the N-terminal helix bundle...
- Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particlesSissel Lund-Katz
Lipid Research Group, Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
J Lipid Res 51:606-17. 2010..This K(d) value does not apply to all of the apoA-I molecules on the HDL particle but only to a relatively small, labile pool...
- Cysteinemia, rather than homocysteinemia, is associated with plasma apolipoprotein A-I levels in hyperhomocysteinemia: lipid metabolism in cystathionine beta-synthase deficiencyMario Nuño-Ayala
Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Instituto Aragones de Ciencias de la Salud, Universidad de Zaragoza Salud del Gobierno de Aragon, Spain
Atherosclerosis 212:268-73. 2010Genetic and dietary hyperhomocysteinemia has been found to decrease high density lipoproteins (HDL) and their apolipoprotein A1 (APOA1)...
- ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosisYaoyong Wang
Department of Aging Biology, Institute on Aging and Adaptation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan
J Lipid Res 52:1461-70. 2011..To study the influence of apoA-I on apoA-II and AApoAII amyloidosis, apoA-I-deficient (C57BL/6J.Apoa1⁻/⁻) mice were used...
- Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the proteinTimothy J Sontag
Department of Pathology, University of Chicago, Chicago, IL, USA
J Lipid Res 53:951-63. 2012....
- The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effectsMaryam Zamanian-Daryoush
Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Biol Chem 288:21237-52. 2013Here, we show that apolipoprotein A1 (apoA1), the major protein component of high density lipoprotein (HDL), through both innate and adaptive immune processes, potently suppresses tumor growth and metastasis in multiple animal tumor ..
- Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipidsPierre R Provost
Laboratory of Ontogeny and Reproduction, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Quebec, Canada
J Endocrinol 200:321-30. 2009..Our results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis...
- Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoproteinJunji Watanabe
Atherosclerosis Research Unit, Department of Medicine Cardiology, University of California, Los Angeles, California 90095, USA
J Biol Chem 284:18292-301. 2009..Our data strongly suggest that HDL can become proinflammatory via the Hb x Hp pathway in mice and humans, and dissociation of Hb x Hp x Hx complexes from apoA-1-containing particles of HDL may be a novel target for the treatment of CHD...
- Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclassesE M Rubin
Division of Research Medicine and Radiation Biophysics, Lawrence Berkeley Laboratory, University of California, Berkeley 94720
Proc Natl Acad Sci U S A 88:434-8. 1991..These results suggest a dominant role of apoAI in determining the HDL particle size distribution and a mechanism involving expression of human apoAI transgenes that alters the plasma levels of mouse apoAI...
- Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresisL S Ramagli
Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
Biochem Genet 28:123-36. 1990..These 16 NHCP genetic marker inheritance differences detected in RIs add to the 23 previously established genetic marker differences between the progenitors...
- Selection of a gene for apolipoprotein A1 using autoantibodies from a patient with systemic lupus erythematosusJ T Merrill
St Lukes Roosevelt Hospital Center, Division of Rheumatology, New York, NY 10019, USA
Arthritis Rheum 38:1655-9. 1995To investigate immunoreactivity of systemic lupus erythematosus (SLE) sera with apolipoprotein A1, (Apo A1), the major lipid-binding protein of high-density lipoprotein (HDL).
- Developmental changes in methylation of spermatogenesis-specific genes include reprogramming in the epididymisM Ariel
Department of Cellular Biochemistry, Hebrew University, Medical School, Jerusalem, Israel
Nat Genet 7:59-63. 1994We have determined the status of DNA methylation at specific sites in three spermatogenesis-specific genes, Pgk-2, ApoA1 and Oct-3/4, throughout the development and differentiation of male germ cells in the mouse...
- Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient miceO Stein
Department of Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 94:9820-4. 1997..These results provide support for the thesis that anti-atherogenicity of high density lipoprotein is related in part to its role in cholesterol removal...
- Repetitive elements in the third intron of murine apolipoprotein A-I geneA N Chiang
Institute of Biochemistry, School of Life Science, National Yang Ming University, Taipei, Taiwan
Biochem Mol Biol Int 43:989-96. 1997..These repetitive motifs are very similar to the sequences flanking human Alu and rodent B1 repetitive elements, although no evidence for the existence of Alu or B1 was found near the peculiar repetitive DNA sequences in apoA-I gene...
- Kinetic characteristics and regulation of HDL cholesteryl ester and apolipoprotein transport in the apoA-I-/- mouseD K Spady
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 75235, USA
J Lipid Res 39:1483-92. 1998..HDL cholesteryl ester transporter activity and scavenger receptor type B1 (SR-BI) protein and mRNA levels were not up-regulated in any organ of apoA-I-/- mice even though these animals lack normal HDL...
- GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryoE E Morrisey
Department of Medicine, University of Chicago, Chicago, Illinois 60637 USA
Genes Dev 12:3579-90. 1998..In addition, these data demonstrate that GATA6 is required for establishment of the endodermally derived bronchial epithelium...
- On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathwayMaki Tsujita
Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
J Lipid Res 46:154-62. 2005..We conclude that the main mechanism for HDL assembly by endogenous apoA-I in HepG2 cells is an autocrine-like reaction in which apoA-I is secreted and then interacts with cellular ABCA1 to generate HDL...
- Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1Ken Kitajima
Institute for Translational Medicine and Therapeutics, University of Pennsylvania Medical Center, 654 BRBII III Labs, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
Atherosclerosis 186:65-73. 2006..Furthermore, AAV1-based vectors generate higher apoA-l levels than AAV5-based vectors. It is possible that the levels of expression achieved using these vectors will be therapeutic in preventing atherosclerosis...
- Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesisShmuel Mandel
Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
Dev Biol 303:814-24. 2007..These results place ADNP at a crucial point of gene regulation, repressing potential endoderm genes and enhancing genes associated with organogenesis/neurogenesis...
- LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FINGeorgios Koukos
Molecular Genetics, Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Biochemistry 46:10713-21. 2007..Both defects can be corrected by treatment with LCAT...
- Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiencyDavid T Valenta
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
J Lipid Res 49:24-32. 2008..Thus, unlike total systemic PLTP, locally produced macrophage-derived PLTP beneficially alters lipoprotein metabolism and reduces lesion progression in hyperlipidemic mice...
- Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null micePin Yue
Department of Medicine, Washington University School of Medicine, Center for Human Nutrition, St Louis, Missouri, United States of America
PLoS ONE 5:e9906. 2010..In conclusion, CD36 influences reverse cholesterol transport and hepatic ApoA-I production. Both pathways are enhanced in CD36 deficiency, increasing HDL concentrations, which suggests the potential benefit of CD36 inhibition...
- APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humansTomoko Inoue
Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Stem Cell Rev 7:43-52. 2011..Moreover, APOA-1 gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans...
- Enhanced binding of apolipoprotein A-I variants associated with hypertriglyceridemia to triglyceride-rich particlesIrina N Gorshkova
Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, Massachusetts 02118, United States
Biochemistry 50:2040-7. 2011..While many factors may be involved in induction of HTG, we suggest that an increased level of association of destabilized loosely folded apolipoproteins with TG-rich lipoproteins may contribute to some cases of HTG in humans...
- HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cellsJonathan E Feig
The Leon H Charney Division of Cardiology, Department of Medicine, The Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 108:7166-71. 2011..Overall, these results establish HDL as a regulator in vivo of the migratory and inflammatory properties of monocyte-derived cells in mouse atherosclerotic plaques, and highlight the phenotypic plasticity of these cells...
- Reduced biliary sterol output with no change in total faecal excretion in mice expressing a human apolipoprotein A-I variantCinzia Parolini
Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy
Liver Int 32:1363-71. 2012....
- Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activityJennifer H Madenspacher
Laboratory of Respiratory Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 287:43730-40. 2012....
- Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDLPanagiotis Fotakis
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118
J Lipid Res 54:3281-92. 2013..Alterations of the charged 223, 226 residues caused milder but discrete changes in HDL phenotype...
- High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in miceMaarit Lehti
Diabetes Research Department IDO and IDR, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, München Neuherberg, Germany M L, M K, T O, C S, S C, P T P, S M H Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH M L, E D, W A, O A M, K M H, J W, C R, J M, S S, C T, R K, S M G, R A G D S, D D, W S D, S M H LIKES Research Center for Sport and Health Sciences, Jyvaskyla, Finland M L Energy Metabolism Laboratory ETH Zurich Swiss Federal Institute of Technology, Zurich, UNICAMP
Circulation 128:2364-71. 2013..We used genetic mouse models with increased HDL levels (apolipoprotein A-I transgenic [apoA-I tg]) and reduced HDL levels (apoA-I-deficient [apoA-I ko]) to investigate whether HDL modulates mitochondrial bioenergetics in skeletal muscle...
- Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarctionAlisher R Dadabayev
Department of Anesthesia, Cleveland Clinic, Cleveland, OH
J Nutr 144:1030-6. 2014HDL and apolipoprotein A1 (apoA1) concentrations inversely correlate with risk of death from ischemic heart disease; however, the role of apoA1 in the myocardial response to ischemia has not been well defined...
- Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone MiceLeland L Black
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294
J Immunol 195:4685-98. 2015....
- [Mapping of apolipoprotein A-1 and ceruloplasmin genes on human, rat and mouse chromosomes by hybridization in situ with specific human DNA probes]V S Baranov
Biull Eksp Biol Med 105:587-9. 1988..Heterologous in situ hybridization of other species with DNA probes does not always give reliable results in gene mapping. Thus, the data of heterologous hybridization should be considered with caution...
- ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in miceAndrew J Murphy
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
J Clin Invest 121:4138-49. 2011..In contrast, Apoa1⁻/⁻ mice showed no monocytosis compared with controls...
- The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1Sophie Stukas
Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
Biochim Biophys Acta 1821:536-46. 2012..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
- Apolipoprotein A-I Helsinki promotes intracellular acyl-CoA cholesterol acyltransferase (ACAT) protein accumulationJuan D Toledo
Facultad de Ciencias Medicas, Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, Universidad Nacional de La Plata, La Plata, Argentina
Mol Cell Biochem 377:197-205. 2013..Although a similar choline-phospholipid efflux is evoked by these apoA-I variants, the change in phosphatidylcholine/sphyngomyelin distribution produced by wild-type apoA-I is not observed with either ∆K107 or ∆K226...
- High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharideMasashi Suzuki
Department of Medicine, University of Washington, Seattle, USA
Circulation 122:1919-27. 2010..High-density lipoprotein (HDL) protects the artery wall by removing cholesterol from lipid-laden macrophages. However, recent evidence suggests that HDL might also inhibit atherogenesis by combating inflammation...
- Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient miceLéa Ritie
INSERM, U682, Strasbourg, France Univ de Strasbourg, France
PLoS ONE 7:e37710. 2012..Thus deregulated adhesion to laminin-511 may be instrumental in diseases such as human pathologies of the gut where laminin-511 is abnormally expressed as it is shown here...
- ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCATAdelina Duka
Molecular Genetics, Boston University School of Medicine, Boston, MA, USA
J Lipid Res 54:107-15. 2013....
- Genome-wide screen for modulation of hepatic apolipoprotein A-I (ApoA-I) secretionRebecca R Miles
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 288:6386-96. 2013..In total, this work underscores the power of functional genetic assessment to identify new therapeutic targets...
- Reverse apolipoprotein A-I mimetic peptide R-D4F inhibits neointimal formation following carotid artery ligation in miceLin Du
Department of Cardiology, Second Clinic Medical College, Yangzhou University, Yangzhou, China
Am J Pathol 182:1932-9. 2013..Taken together, these results suggest that R-D4F has significant anti-inflammatory features and facilitates prevention of neointimal formation after vascular injury in mice...
- High density lipoprotein protects against polymicrobe-induced sepsis in miceLing Guo
Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
J Biol Chem 288:17947-53. 2013..Our study supports efforts to raise HDL levels as a therapeutic approach for sepsis. ..
- Use of two-dimensional electrophoresis to identify and map new mouse genesR W Elliott
Genetics 91:295-308. 1979..These eight genes will be useful reference markers in future crosses designed to map new genes...
- Gene for a serum protein on chromosome 9 in the mouseE M Håkansson
Genet Res 33:147-52. 1979
- Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-IR Williamson
Department of Pathology and Curriculum in Genetics, University of North Carolina, Chapel Hill 27599 7525
Proc Natl Acad Sci U S A 89:7134-8. 1992....
- Dietary fatty acids and dietary cholesterol differ in their effect on the in vivo regulation of apolipoprotein A-I and A-II gene expression in inbred strains of miceR A Srivastava
Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 68110
Biochim Biophys Acta 1125:251-61. 1992..This study identifies potential loci of regulation and forms the basis for future studies investigating specific genetic and molecular regulatory mechanisms...
- Structure of the murine gene encoding apolipoprotein A-IT P Boyle
Upjohn Laboratories, Kalamazoo, MI 49007
Gene 117:243-7. 1992..4). Kyte-Doolittle analyses of the three proteins indicate that there is no significant difference in the structure of these apolipoproteins...
- Structure, expression and chromosomal location of the Oct-4 geneY I Yeom
Department of Zoology, University of Texas, Austin
Mech Dev 35:171-9. 1991..By in situ hybridization, detectable onset of zygotic Oct-4 expression does not occur until compaction begins at 8-cells, suggesting that there might be other regulatory factors responsible for initiating Oct-4 expression...
- Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in miceB Paigen
Children s Hospital Oakland Research Institute, Children s Hospital Medical Center, Oakland 94609
Genetics 122:163-8. 1989..Recombinant inbred strains derived from C57BL/6 and A were characterized for Apoa 1, Apoa 2 and susceptibility to atherosclerosis...
- Genetic mapping of mouse T3d and T3e between Apoa1 and NcamR D Miller
Division of Molecular Biology, Medical Biological Institute, La Jolla, CA 92037
Immunogenetics 30:511-4. 1989
- Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocksM Prochazka
Jackson Laboratory, Bar Harbor, ME 04609
Diabetes 38:1446-55. 1989..abstract truncated at 400 words)..
- The structural genes encoding P450scc and P450arom are closely linked on mouse chromosome 9G L Youngblood
Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0278
Endocrinology 125:2784-6. 1989..The information presented in this report, along with other studies, indicate conservation between homologous human and mouse chromosomal regions and suggest that human P450SCC will be found to be closely linked with human P450arom...
- Fourteen genetically variant proteins of mouse brain: discovery of two new variants and chromosomal mapping of four lociD Goldman
Biochem Genet 24:183-94. 1986..In addition to these 13 genetically variant polypeptides, the positions of 12 other polypeptides which have been identified on 2DE gels of mouse brain are given...
- Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneityA Scanu
Biochemistry 8:3309-16. 1969
- Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumorJ H Russell
Immunogenetics 14:263-72. 1981..The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes...
- Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasmaJ S Parks
Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
J Lipid Res 36:349-55. 1995..abstract truncated at 250 words)..
- Nucleotide sequence of mouse spermidine synthase cDNAS Myöhänen
Department of Biochemistry and Biotechnology, University of Kuopio, Finland
DNA Seq 4:343-6. 1994..The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E. coli spermidine synthase. The 3' flanking region contained an unusual polyadenylation signal AATACA...
- Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipaseC H Warden
Department of Microbiology and Molecular Genetics, University of California, Los Angeles, 90024
J Lipid Res 34:1451-5. 1993..Comparison of chromosomal locations for these genes in mouse and humans shows that the previously observed interspecies syntenies are preserved...
- Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aH Shimano
Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
J Clin Invest 98:1575-84. 1996..The amount of white adipose tissue decreased progressively as the liver enlarged. These studies indicate that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver...
- Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient miceN R Webb
Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536, USA
J Lipid Res 38:1583-90. 1997..We conclude that SAA is unable to substitute for apoA-I in HDL particle formation...
- ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophagesW A Boisvert
Scripps Research Institute, Departments of Immunology, and Vascular Biology, La Jolla, CA, USA
Arterioscler Thromb Vasc Biol 19:525-30. 1999Along with apolipoprotein (apo) E, which promotes cholesterol efflux from foam cells, apoA1-containing high density lipoprotein (HDL) is thought to facilitate the transport of cholesterol from lesions...
- Human growth hormone increases apo(a) expression in transgenic miceR Tao
Departments of Internal Medicine and Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
Arterioscler Thromb Vasc Biol 19:2439-47. 1999..The coordinate changes in apo(a) mRNA and plasma levels of apo(a) in response to rhGH and IGF-1 strongly suggest that these 2 hormones have independent effects on the transcription of the apo(a) gene...
- The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreasA E Allen-Jennings
Department of Molecular and Cellular Biochemistry, Ohio State Biochemistry Program, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 276:29507-14. 2001..Because ATF3 is a stress-inducible gene, these mice may represent a model to investigate the molecular mechanisms for some stress-associated diseases...
- Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-IMirko Ritter
Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
Genomics 79:693-702. 2002..The stimulation of cells derived from the kidney proximal tubules with apoA-I or HDL induces a concentration-dependent secretion of AI-BP indicating an important role for AI-BP, in the renal tubular degradation or resorption of apoA-I...
- Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptakeRyan E Temel
Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
J Biol Chem 277:26565-72. 2002..The reduced V(max) for HDL CE-selective uptake likely contributes to the severe reduction in CE accumulation in steroidogenic cells of apoA-I(-/-) mice...
- Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol effluxMiriam Lee
Wihuri Research Institute, Helsinki, Finland
Arterioscler Thromb Vasc Biol 22:1475-81. 2002....
- The roles of circulating high-density lipoproteins and trophic hormones in the phenotype of knockout mice lacking the steroidogenic acute regulatory proteinTomohiro Ishii
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
Mol Endocrinol 16:2297-309. 2002....
- A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-INan Wang
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
J Clin Invest 111:99-107. 2003..Inhibition of ABCA1 degradation by calpain could represent a novel therapeutic approach to increasing macrophage cholesterol efflux and decreasing atherosclerosis...
- Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1Omar L Francone
Pfizer Global Research and Development, Groton, Connecticut 06340, USA
Biochemistry 42:8569-78. 2003..Taken together, these observations suggest that ABCA1 is necessary for the adequate lipidation of apoAI, which enables the interaction with LCAT and subsequent maturation...
- Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particlesLijuan Liu
Gastrointestinal Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
J Biol Chem 278:42976-84. 2003..This is consistent with lipid raft and non-raft plasma membrane domains being involved primarily in ABCA1-mediated vesicle release and nascent HDL formation, respectively...
- Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterolManal Zabalawi
Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Am J Pathol 163:1201-13. 2003....
- Potential involvement of dissociated apoA-I in the ABCA1-dependent cellular lipid release by HDLKei ichiro Okuhira
Biochemistry, Cell Biology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
J Lipid Res 45:645-52. 2004..The data implicated that the ABCA1-dependent cholesterol release to HDL is mediated by apoA-I dissociated from HDL...
- Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 miceJun ichi Suto
Department of Molecular Biology and Immunology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8602, Japan
Biochem Genet 41:325-41. 2003..Identification of distinct, but related traits in an identical chromosomal region will facilitate revealing the responsible gene...
- Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylasesLiqiang Tou
Department of Medical Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Mol Cell Biol 24:3132-9. 2004..Thus, modulation of endogenous class I HDAC levels represents a previously unappreciated mechanism to enable onset of tissue-restricted gene expression in a developing mammalian organ...
- Role of apolipoprotein A-I in protecting against endotoxin toxicityJuan Ma
Department of Biochemistry, School of Pharmacy, Fudan University, Shanghai 200032, China
Acta Biochim Biophys Sin (Shanghai) 36:419-24. 2004..35 +/- 3.70) (P<0.01). The results suggest that: (1) ApoA-I has the ability to bind with and protect against LPS; (2) LFF enhances the effect of ApoA-I; (3) ApoA-I is the major contributor for HDL anti-endotoxin function...
- Remodeling of HDL remnants generated by scavenger receptor class B type INancy R Webb
Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
J Lipid Res 45:1666-73. 2004..We conclude that HDL remnants, generated by SR-BI, are converted to larger particles by rapidly reassociating with existing HDL particles in an enzyme-independent manner...
- Deficiency of ABCA1 impairs apolipoprotein E metabolism in brainVeronica Hirsch-Reinshagen
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver V5Z 4H4, Canada
J Biol Chem 279:41197-207. 2004..Additionally, the effect of ABCA1 on apoE is selective, as apoJ levels are unchanged in brains of ABCA1-/- mice. Taken together, these results show that glial ABCA1 is a key influence on apoE metabolism in the CNS...
- The expression of intact and mutant human apoAI/CIII/AIV/AV gene cluster in transgenic miceJun Gao
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, People s Republic of China
J Biol Chem 280:12559-66. 2005....
- Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteinsYue Zhao
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
Biochemistry 44:1013-25. 2005..We conclude that apoE is a more significant activator of LCAT than apoA-I on mouse apoB lipoproteins...
- Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-IMarnie L Gruen
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Lipid Res 46:2007-14. 2005..Moreover, the presence of large HDLs without apoA-I provides evidence for an apoA-I-independent pathway of cholesterol efflux, possibly sustained by apoE...
- Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse modelCinzia Parolini
Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
Atherosclerosis 183:222-9. 2005..685). Our data suggest that, in the atherosclerosis-susceptible human apoB/A-II mouse model, expression of the human apoA-I(M) gene does not have protective advantage over that of the apoA-I gene...
- Overexpression of human ApoAI transgene provides long-term atheroprotection in LDL receptor-deficient miceDavid T Valenta
Department of Immunology, The Scripps Research Institute, 10550 North Torrey, Pines Road, La Jolla, CA 92037, USA
Atherosclerosis 189:255-63. 2006..This was observed without a change in total HDL cholesterol levels. Thus, elevated levels of human apoAI in LDL receptor-deficient mice lacking mouse apoAI conferred profound protection against diet-induced over extended periods of time...
- 2006 Lipoprotein Metabolism Gordon ConferenceMARY SORCI THOMAS; Fiscal Year: 2006....
- APOLIPOPROTEIN VARIATION AND HUMAN DISEASEVassilis Zannis; Fiscal Year: 2003..Thus the information obtained from this project may provide rational approaches towards correcting low plasma HDL levels and reducing hypertriglyceridemia in humans. ..
- Expression profiling of human isletsKLAUS KAESTNER; Fiscal Year: 2006....
- Group V Secretory Phospholipase A2 in AtherosclerosisNancy Webb; Fiscal Year: 2007..Measuring lesion size and cholesterol/cholesterol ester content will assess the extent of atherosclerosis. [unreadable] [unreadable]..
- FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATIONKLAUS KAESTNER; Fiscal Year: 2003....
- EFFECTS OF AGING & PGP ON AB EFFLUX FROM THE BRAINANNE FAGAN NIVEN; Fiscal Year: 2005..Support for the hypothesis would establish a role for age-dependent defects in A-beta clearance from the brain in the pathogenesis of AD and, importantly, provide a novel therapeutic target for treatment of the disease. ..
- Therapeutic potential-LXR ligands in Alzheimer's DiseaseIliya Lefterov; Fiscal Year: 2005..abstract_text> ..
- ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's DiseaseIliya Lefterov; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Development of C57BL/6 ES cell technology for high thoughput use.KLAUS KAESTNER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- FUNCTIONAL GENOMICS OF THE BETA-CELLKLAUS KAESTNER; Fiscal Year: 2007..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
- Liver Biology, Development and DiseaseKLAUS KAESTNER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Functions of apoE in cholesterol and triglyceride homeostasisVassilis I Zannis; Fiscal Year: 2010..Gene transfer in single or double knockout mice for apoA-l, apoE, SR-BI and biochemical analyses will be employed in these studies. ..