Ank1

Summary

Gene Symbol: Ank1
Description: ankyrin 1, erythroid
Alias: Ank-1, pale, ankyrin-1, erythrocyte ankyrin, normoblastic anemia
Species: mouse

Top Publications

  1. ncbi Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene
    C S Birkenmeier
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Biol Chem 268:9533-40. 1993
  2. ncbi Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis
    S W Eber
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 13:214-8. 1996
  3. pmc Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle
    D Zhou
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Cell Biol 136:621-31. 1997
  4. pmc A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis
    Michael R Hughes
    The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada
    Exp Hematol 39:305-20, 320.e1-2. 2011
  5. doi Host resistance to malaria: using mouse models to explore the host response
    Rhea Longley
    Menzies Research Institute, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia
    Mamm Genome 22:32-42. 2011
  6. pmc A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice
    Andreas Greth
    The Menzies Research Institute of Tasmania, University of Tasmania, Hobart, Australia
    PLoS ONE 7:e38999. 2012
  7. ncbi Resistance to malaria in ankyrin and spectrin deficient mice
    H L Shear
    Department of Medical and Molecular Parasitology, New York University School of Medicine, N Y
    Br J Haematol 78:555-60. 1991
  8. pmc Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice
    E Kordeli
    Howard Hughes Medical Institute, Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Cell Biol 114:1243-59. 1991
  9. ncbi Red cell membranes of ankyrin-deficient nb/nb mice lack band 3 tetramers but contain normal membrane skeletons
    S J Yi
    Department of Biomedical Research, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, Boston, Massachusetts, USA
    Biochemistry 36:9596-604. 1997
  10. pmc Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant
    Gerhard Rank
    Rotary Bone Marrow Research Laboratory, Melbourne Health Research Directorate, Parkville, Australia
    Blood 113:3352-62. 2009

Scientific Experts

  • Peng Ji
  • K Hofmann
  • Nelson W Chong
  • Michael C Stankewich
  • J E Barker
  • Michael R Hughes
  • L L Peters
  • Luanne L Peters
  • Narla Mohandas
  • Emiliana Giacomello
  • E Giacomello
  • Yvonne L Clarkson
  • Tammy Szu Yu Ho
  • Connie S Birkenmeier
  • Katrina Kildey
  • Hua Huang
  • Kyoko E Yuki
  • Gayani C Kodippili
  • Andreas Greth
  • Samir Ounzain
  • Gaétan Burgio
  • Kelly M McNagny
  • Weiyan Peng
  • C S Birkenmeier
  • Rhea Longley
  • Simon J Foote
  • Marcela Salomao
  • Philip S Low
  • Eric M Small
  • Gerhard Rank
  • Diana M Gilligan
  • M Estela Campanella
  • Raymond F Robledo
  • Connie Birkenmeier
  • Vincenzo Sorrentino
  • Douglas G Nilson
  • Andrea Armani
  • P G Gallagher
  • Virginie Nicolas
  • C Reggiani
  • V Sorrentino
  • C Paolini
  • M Quarta
  • F Francini
  • L Formoso
  • D Rossi
  • L Toniolo
  • C Birkenmeier
  • R Squecco
  • F Protasi
  • S E Lux
  • P Fusco
  • B Blaauw
  • Callum J Cairncross
  • Vann Bennett
  • Mingxuan Xu
  • Alastair R Lyndon
  • Daniel R Zollinger
  • Emma M Perkins
  • Matthew N Rasband
  • Paul A Skehel
  • Kae Jiun Chang
  • Edward C Cooper
  • Mandy Jackson
  • François Canonne-Hergaux
  • Marilene Paquet
  • Emily Fu
  • Melinda M Dean
  • Xin Du
  • Silvia M Vidal
  • Robert L Flower
  • Megan M Eva
  • Jonathan Harris
  • Robert Tunningley
  • Dudley Chung
  • Lara Krieg
  • Kei Arimatsu
  • Mathieu Cellier
  • Danielle Malo
  • Tian Zhang
  • Etienne Richer
  • Koichi Tabeta
  • Pengxiang Zhao
  • Sophie Vaulont
  • Kazuhisa Yamazaki
  • Thu V Tran
  • Preethi Mayura-Guru
  • LUANNE PETERS
  • Brendan J McMorran
  • Qiangrong Liang

Detail Information

Publications58

  1. ncbi Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene
    C S Birkenmeier
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Biol Chem 268:9533-40. 1993
    ....
  2. ncbi Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis
    S W Eber
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 13:214-8. 1996
    ....
  3. pmc Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle
    D Zhou
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Cell Biol 136:621-31. 1997
    We have recently found that the erythroid ankyrin gene, Ank1, expresses isoforms in mouse skeletal muscle, several of which share COOH-terminal sequence with previously known Ank1 isoforms but have a novel, highly hydrophobic 72-amino ..
  4. pmc A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis
    Michael R Hughes
    The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada
    Exp Hematol 39:305-20, 320.e1-2. 2011
    ..We investigated a novel mouse model in which the heterozygotes present with the diagnostic hallmarks of mild HS and surviving homozygotes phenocopy severe hemolytic HS...
  5. doi Host resistance to malaria: using mouse models to explore the host response
    Rhea Longley
    Menzies Research Institute, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia
    Mamm Genome 22:32-42. 2011
    ..Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials...
  6. pmc A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice
    Andreas Greth
    The Menzies Research Institute of Tasmania, University of Tasmania, Hobart, Australia
    PLoS ONE 7:e38999. 2012
    ..ENU) mutagenesis screen and have identified a novel dominant (haploinsufficient) mutation in the Ank-1 gene (Ank1(MRI23420)) of mice displaying hereditary spherocytosis (HS)...
  7. ncbi Resistance to malaria in ankyrin and spectrin deficient mice
    H L Shear
    Department of Medical and Molecular Parasitology, New York University School of Medicine, N Y
    Br J Haematol 78:555-60. 1991
    ..The heterozygote for the nb defect (nb/+) exhibited a diminution of parasitaemia. We conclude that the host cell spectrin may be necessary for the invasion and/or growth of rodent malarial parasites...
  8. pmc Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice
    E Kordeli
    Howard Hughes Medical Institute, Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Cell Biol 114:1243-59. 1991
    Isoforms of ankyrin (ankyrinsR) immunologically related to erythrocyte ankyrin (ankyrinRo) are associated with distinct neuronal plasma membrane domains of functional importance, such as cell bodies and dendrites, axonal hillock and ..
  9. ncbi Red cell membranes of ankyrin-deficient nb/nb mice lack band 3 tetramers but contain normal membrane skeletons
    S J Yi
    Department of Biomedical Research, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, Boston, Massachusetts, USA
    Biochemistry 36:9596-604. 1997
    ..The absence of band 3 tetramers in the membrane of ankyrin-deficient red cells suggests that ankyrin is required for the formation of stable band 3 tetramers...
  10. pmc Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant
    Gerhard Rank
    Rotary Bone Marrow Research Laboratory, Melbourne Health Research Directorate, Parkville, Australia
    Blood 113:3352-62. 2009
    ..These findings provide novel insights into the role of Ank-1, and define an ideal model for the study of HS and malarial resistance...
  11. ncbi Normoblastosis, a murine model for ankyrin-deficient hemolytic anemia, is caused by a hypomorphic mutation in the erythroid ankyrin gene Ank1
    Connie S Birkenmeier
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hematol J 4:445-9. 2003
    ..Study of this model has led to the finding of multiple isoforms of Ank1 as well as Ank1nb-related pathology in nonerythroid tissues...
  12. pmc Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain
    L L Peters
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Cell Biol 130:313-30. 1995
    ..The Ank3 gene maps to mouse Chromosome 10, approximately 36 cM from the centromere, a locus distinct from Ank1 and Ank2. Ank3 is the major kidney ankyrin. Multiple transcripts of approximately 7.5, 6.9, 6.3, 5.7, 5.1, and 4...
  13. pmc Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice
    L L Peters
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Cell Biol 114:1233-41. 1991
    ..Ank-2 maps to Chromosome 3 and its expression is unaffected by the nb mutation. We conclude that Ank-1 is specifically required for Purkinje cell stability and, in its absence, Purkinje cell loss and neurological symptoms appear...
  14. pmc Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin
    R A White
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 87:3117-21. 1990
    ..The linkage data suggest that the mouse and human diseases result from mutations in homologous loci...
  15. ncbi Murine erythrocyte ankyrin cDNA: highly conserved regions of the regulatory domain
    R A White
    Hematology Oncology Division, Children s Hospital, Boston, Massachusetts
    Mamm Genome 3:281-5. 1992
    ..However, the C-terminal regulatory domain contains two regions of peptide sequence that are perfectly conserved. We postulate these regions are important in the regulatory functions of this domain...
  16. ncbi Distinct fetal Ank-1 and Ank-2 related proteins and mRNAs in normal and nb/nb mice
    L L Peters
    Jackson Laboratory, Bar Harbor, ME 04609
    Blood 81:2144-9. 1993
    ....
  17. ncbi Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes
    D M Bodine
    Cell 37:721-9. 1984
    ..Analysis of spectrin synthesis in mice homozygous and heterozygous for several alleles of sph indicates that the sph locus is the structural gene locus for alpha spectrin. We have mapped the sph locus to mouse Chromosome 1...
  18. pmc A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier
    Tammy Szu Yu Ho
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    Nat Neurosci 17:1664-72. 2014
    ..Unexpectedly, in the absence of ankyrin-G, erythrocyte ankyrin (ankyrin-R) and its binding partner βI spectrin substitute for and rescue nodal Na(+) channel clustering...
  19. doi Deletion of small ankyrin 1 (sAnk1) isoforms results in structural and functional alterations in aging skeletal muscle fibers
    E Giacomello
    Molecular Medicine Section, Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy IIM Interuniversity Institute of Myology
    Am J Physiol Cell Physiol 308:C123-38. 2015
    Muscle-specific ankyrins 1 (sAnk1) are a group of small ankyrin 1 isoforms, of which sAnk1.5 is the most abundant...
  20. pmc Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins
    Katrina Kildey
    Research and Development, Australian Red Cross Blood Service, Brisbane, Australia Queensland University of Technology, Brisbane, Australia
    Comput Struct Biotechnol J 6:e201303012. 2013
    ..Exome sequencing revealed a novel single nucleotide variation (SNV) in Ank1 encoding the RBC structural protein ankyrin-1 and the pedigree was designated Ank1(EX34)...
  21. pmc β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations
    Yvonne L Clarkson
    The Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK and
    Hum Mol Genet 23:3875-82. 2014
    ....
  22. pmc A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice
    Hua Huang
    Department of Medicine, University of California, San Diego, La Jolla, California 92093
    G3 (Bethesda) 3:1687-95. 2013
    ..The causal mutation was traced to a single nucleotide transition located deep into intron 13 of gene Ank1. In vitro minigene splicing assay revealed two abnormally spliced transcripts containing cryptic exons from ..
  23. pmc Cell organization, growth, and neural and cardiac development require αII-spectrin
    Michael C Stankewich
    Department of Pathology, Yale University School of Medicine, 310 Cedar St BML 150, New Haven, CT 06520, USA
    J Cell Sci 124:3956-66. 2011
    ..These data indicate that the spectrin-ankyrin scaffold is crucial in vertebrates for cell spreading, tissue patterning and organ development, particularly in the developing brain and heart, but is not required for cell viability...
  24. pmc Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation
    Peng Ji
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Biochem Biophys Res Commun 417:1188-92. 2012
    ..However, neither band 3 nor ankyrin are required for enucleation. These results demonstrate that mammalian erythroblast enucleation does not depend on the membrane integrity generated by the ankyrin-band 3 complex...
  25. pmc Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4
    Samir Ounzain
    Cardiology Group, Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom
    Mol Cell Biol 32:1830-43. 2012
    ..This GATA4-dependent repression of ms1/STARS expression has major implications for MRTF-SRF signaling in the context of cardiac development and disease...
  26. pmc Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes
    Gayani C Kodippili
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 287:4129-38. 2012
    ....
  27. pmc Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant
    Kyoko E Yuki
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e55331. 2013
    ..The position of Ity16 was refined on chromosome 8 and a nonsense mutation was identified in the ankyrin 1 (Ank1) gene. ANK1 plays an important role in the formation and stabilization of the red cell cytoskeleton...
  28. pmc Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation
    Marcela Salomao
    The Red Cell Physiology Laboratory, The New York Blood Center, New York, NY, USA
    Blood 116:267-9. 2010
    ..We conclude that aberrant protein sorting is one mechanistic basis for protein deficiencies in HE and HS...
  29. pmc Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486
    Eric M Small
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 107:4218-23. 2010
    ..Our findings implicate miR-486 as a downstream mediator of the actions of SRF/MRTF-A and MyoD in muscle cells and as a potential modulator of PI3K/Akt signaling...
  30. doi RGD-containing ankyrin externalized onto the cell surface triggers αVβ3 integrin-mediated erythrophagocytosis
    Weiyan Peng
    Department of Bioengineering, University of California, San Diego, CA 92093 0412, USA
    Biochem Biophys Res Commun 407:466-71. 2011
    ..Thus, externalization of ankyrin followed by RGD/integrin recognition may be a novel mechanism by which erythrocytes adhere to macrophages preceding phagocytosis...
  31. doi Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres
    Emiliana Giacomello
    Department of Neuroscience, Interuniversity Institute of Myology, University of Siena, Siena, Italy
    Histochem Cell Biol 131:371-82. 2009
    b>Ank1.5 is a muscle-specific isoform of ankyrin1 localized on the sarcoplasmic reticulum (SR) membrane that has been shown to interact with obscurin, a sarcomeric protein. We report here studies on the localization of obscurin and ank1...
  32. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  33. pmc Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice
    M Estela Campanella
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Blood 112:3900-6. 2008
    ..These data suggest that oxygenation-dependent assembly of GEs on the membrane could be a general phenomenon of mammalian erythrocytes and that stability of these interactions depends primarily on band 3...
  34. ncbi Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum
    Andrea Armani
    Molecular Medicine Section, Department of Neuroscience, University of Siena, 53100 Siena, Italy
    Exp Cell Res 312:3546-58. 2006
    ..A novel small muscle-specific ankyrin isoform, ank1.9 was identified that, similarly to the known ank1...
  35. ncbi Major erythrocyte membrane protein genes in EKLF-deficient mice
    Douglas G Nilson
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 34:705-12. 2006
    ..The objectives of this study were to rescue EKLF-deficient embryos with mice expressing gamma-globin from beta-spectrin or ankyrin promoters and to characterize expression of the major erythrocyte membrane genes in EKLF-deficient cells...
  36. ncbi An alternative first exon in the distal end of the erythroid ankyrin gene leads to production of a small isoform containing an NH2-terminal membrane anchor
    C S Birkenmeier
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 50:79-88. 1998
    Mouse erythroid ankyrin is encoded by the Ank1 gene on Chromosome 8. The best studied isoform is 210 kDa and contains three large functional domains...
  37. ncbi Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons
    C H Joiner
    Department of Pediatrics, University of Cincinnati College of Medicine, OH, USA
    Blood 86:4307-14. 1995
    ....
  38. ncbi Molecular pathology of inherited erythrocyte membrane disorders: hereditary spherocytosis and elliptocytosis
    A Iolascon
    Dipartimento di Pediatria, Clinica Pediatrica Ia, Universita, Napoli, Italy
    Haematologica 77:60-72. 1992
    ..This paper will review the effects of recent advances upon: cytoskeleton structure and assembly; molecular pathology of spherocytosis, elliptocytosis and pyropoikilocytosis...
  39. pmc Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo
    L L Peters
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 89:5749-53. 1992
    ....
  40. ncbi Fetal compensation of the hemolytic anemia in mice homozygous for the normoblastosis (nb) mutation
    L L Peters
    Jackson Laboratory, Bar Harbor, ME 04609
    Blood 80:2122-7. 1992
    ....
  41. ncbi Mapping of the motor neuron degeneration (Mnd) gene, a mouse model of amyotrophic lateral sclerosis (ALS)
    A Messer
    Wadsworth Center for Laboratories and Research, New York State Department of Health
    Genomics 13:797-802. 1992
    ..The Mnd mouse model should allow study of mechanisms affecting onset and progression of specific neuronal degeneration in both animal and human neurological disease...
  42. ncbi Zinc finger protein gene complexes on mouse chromosomes 8 and 11
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 8:469-76. 1990
    ..Surprisingly, both genes were closely linked to two previously mapped, Krüppel-related zinc finger protein genes, suggesting that they are part of gene complexes...
  43. ncbi Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y)
    M Kreimer-Birnbaum
    Comp Biochem Physiol A Comp Physiol 43:21-30. 1972
  44. ncbi Hereditary disorders of the red cell in animals
    R M Bannerman
    Prog Hematol 8:131-79. 1973
  45. ncbi Kinetic aspects of endogenous carbon monoxide production in experimental animals
    S A Landaw
    Ann N Y Acad Sci 174:32-48. 1970
  46. pmc Studies on the pathogenesis of pigment gallstones in hemolytic anemia: description and characteristics of a mouse model
    B W Trotman
    J Clin Invest 65:1301-8. 1980
    ..pathogenesis of hemolysis-induced gallstones was studied in mice with a hereditary hemolytic disease called normoblastic anemia (genotype nb/nb) and in their normal controls (genotype +/+)...
  47. ncbi Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation
    Virginie Nicolas
    INSERM U76, Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75015 Paris, France
    J Biol Chem 278:25526-33. 2003
    ..These results identify the Rh/RhAG-ankyrin complex as a new interaction site between the red cell membrane and the spectrin-based skeleton, the disruption of which might result in the stomato-spherocytosis typical of Rhnull red cells...
  48. pmc Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice
    L Barisoni
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Am J Pathol 147:1728-35. 1995
    ....
  49. ncbi Decreased content of protein 4.2 in ankyrin-deficient normoblastosis (nb/nb) mouse red blood cells: evidence for ankyrin enhancement of protein 4.2 membrane binding
    A C Rybicki
    Albert Einstein College of Medicine Montefiore Medical Center, Division of Hematology, Bronx, NY 10467, USA
    Blood 86:3583-9. 1995
    ..2 by approximately 60%. These results suggest that ankyrin is required for normal associations of P4.2 with the RBC membrane...
  50. ncbi Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14
    T Koizumi
    Laboratory Animal Center, Fukui Medical School, Japan
    Mamm Genome 6:263-8. 1995
    ..Finally, we identified either a closely linked sequence related to Col4a2, or a recombination hot-spot between Col4a1 and Col4a2 that has been conserved in humans and mice...
  51. ncbi Novel inheritance of the murine severe combined anemia and thrombocytopenia (Scat) phenotype
    L L Peters
    Jackson Laboratory, Bar Harbor, Maine 04609
    Cell 74:135-42. 1993
    ..We conclude that contribution from the maternal wild-type allele is required for expression of the scat phenotype in homozygotes...
  52. ncbi A high-resolution genetic map of the nervous locus on mouse chromosome 8
    P L De Jager
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Genomics 48:346-53. 1998
    ..We used this map position to identify and evaluate three genes-ankyrin 1, cortexin, and farnesyltransferase-as candidates for the nr gene...
  53. ncbi Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease
    S Sassa
    Exp Hematol 6:479-87. 1978
    ....
  54. ncbi The modular nature of apoptotic signaling proteins
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Cell Mol Life Sci 55:1113-28. 1999
    ....
  55. ncbi Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia
    N J Wandersee
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Blood Cells Mol Dis 26:75-83. 2000
    ..PS exposure is elevated in all mice with HS and HE, but the percentage of RBCs with exposed PS does not correlate with thrombotic risk in these mice...
  56. ncbi A minimal ankyrin promoter linked to a human gamma-globin gene demonstrates erythroid specific copy number dependent expression with minimal position or enhancer dependence in transgenic mice
    D E Sabatino
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:28549-54. 2000
    ..These data indicate that the minimal ankyrin promoter contains all sequences necessary and sufficient for erythroid-specific, copy number-dependent, position-independent expression of the human (A)gamma-globin gene...
  57. ncbi Gene transfer to ankyrin-deficient bone marrow corrects spherocytosis in vitro
    G J Dooner
    Cancer Center and Gene Therapy Link Laboratory, University of Massachusetts Medical School, Worcester, USA
    Exp Hematol 28:765-74. 2000
    ....