Alox5

Summary

Gene Symbol: Alox5
Description: arachidonate 5-lipoxygenase
Alias: 5-LO, 5-LOX, 5LO, 5LX, AI850497, F730011J02, arachidonate 5-lipoxygenase, 5-lipoxygenase
Species: mouse

Top Publications

  1. pmc Altered inflammatory responses in leukotriene-deficient mice
    J L Goulet
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7020
    Proc Natl Acad Sci U S A 91:12852-6. 1994
  2. ncbi Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
    X S Chen
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232
    Nature 372:179-82. 1994
  3. ncbi Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities
    M B Bailie
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 157:5221-4. 1996
  4. ncbi Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice
    J L Goulet
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Immunol 167:6631-6. 2001
  5. ncbi Cloning and functional analysis of the mouse 5-lipoxygenase promoter
    Eric S Silverman
    Pulmonary and Critical Care Division and Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 26:475-83. 2002
  6. ncbi 5-lipoxygenase and cyclooxygenase regulate wound closure in NIH/3T3 fibroblast monolayers
    J Angelo Green
    Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Am J Physiol Cell Physiol 287:C373-83. 2004
  7. pmc Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase
    Carlos H C Serezani
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Blood 106:1067-75. 2005
  8. pmc Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 115:1601-6. 2005
  9. ncbi Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils
    Carlos H C Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Medical School, University of Michigan Health System, 6301 MSRB III, Box 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    J Leukoc Biol 78:976-84. 2005
  10. ncbi Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    Margarete Mehrabian
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
    Nat Genet 37:1224-33. 2005

Scientific Experts

Detail Information

Publications126 found, 100 shown here

  1. pmc Altered inflammatory responses in leukotriene-deficient mice
    J L Goulet
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7020
    Proc Natl Acad Sci U S A 91:12852-6. 1994
    ..we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene...
  2. ncbi Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
    X S Chen
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232
    Nature 372:179-82. 1994
    ..5-Lipoxygenase-deficient (5LX-/-) mice develop normally and are healthy. They show a selective opposition to certain inflammatory insults...
  3. ncbi Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities
    M B Bailie
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 157:5221-4. 1996
    ..We conclude that endogenous LTs play a critical role in the defense against bacterial pneumonia in this murine model...
  4. ncbi Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice
    J L Goulet
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Immunol 167:6631-6. 2001
    ..we transplanted kidneys from CByD2F1 mice into fully allogeneic 129 mice that carry a targeted mutation in the 5lo gene...
  5. ncbi Cloning and functional analysis of the mouse 5-lipoxygenase promoter
    Eric S Silverman
    Pulmonary and Critical Care Division and Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 26:475-83. 2002
    5-lipoxygenase (ALOX5), an enzyme essential for the formation of all leukotrienes, is highly regulated at multiple levels, including gene transcription. The human ALOX5 promoter sequence has been cloned and is well characterized...
  6. ncbi 5-lipoxygenase and cyclooxygenase regulate wound closure in NIH/3T3 fibroblast monolayers
    J Angelo Green
    Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Am J Physiol Cell Physiol 287:C373-83. 2004
    ..These data suggest that two competing oxidative enzymes in arachidonate metabolism, LOX and COX, differentially regulate sequential aspects of fibroblast wound closure in vitro...
  7. pmc Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase
    Carlos H C Serezani
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Blood 106:1067-75. 2005
    ..Our results demonstrate that LTs, especially LTB4, enhanceAM microbicidal activity through the PKC-delta-dependent activation of NADPH oxidase...
  8. pmc Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 115:1601-6. 2005
    ..tuberculosis...
  9. ncbi Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils
    Carlos H C Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Medical School, University of Michigan Health System, 6301 MSRB III, Box 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    J Leukoc Biol 78:976-84. 2005
    ..These results identify a heretofore unrecognized role for activation of 5-LO and subsequent production of LTB(4) in stimulation of PMN NADPH oxidase activation by PUFAs...
  10. ncbi Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    Margarete Mehrabian
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
    Nat Genet 37:1224-33. 2005
    ....
  11. pmc Neutrophil-derived leukotriene B4 is required for inflammatory arthritis
    Mei Chen
    Department of Medicine and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:837-42. 2006
    ..These experiments demonstrate a nonredundant role for LTB4 in inflammatory arthritis and define a neutrophil mediator involved in orchestrating the synovial eruption...
  12. ncbi Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
    Anna Adamek
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Germany
    Eur J Pharmacol 571:51-4. 2007
    ..In summary, inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response...
  13. ncbi IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Eur J Immunol 37:3373-80. 2007
    ....
  14. pmc 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease
    Omidreza Firuzi
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    FASEB J 22:1169-78. 2008
    5-Lipoxygenase (5LO), by producing leukotrienes, is a proinflammatory enzyme, and there is evidence suggesting that it is up-regulated with aging and may be involved in Alzheimer's disease (AD)...
  15. pmc 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy
    Rose A Gubitosi-Klug
    Department of Pediatrics, Case Western Reserve University Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Diabetes 57:1387-93. 2008
    ..Lipoxygenases are regulators of chronic inflammation and oxidative stress generation. We evaluated the role of 5- and 12-lipoxygenases in the development of diabetic retinopathy...
  16. pmc Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 436:269-72. 2008
    ..Increased activity of the enzymatic 5-lipoxygenase (5-LOX, 5LO) pathway is a contributing factor in atherosclerosis and a 5-LOX inhibitor, MK-886, is beneficial in animal models ..
  17. pmc Identification of ALOX5 as a gene regulating adiposity and pancreatic function
    M Mehrabian
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Diabetologia 51:978-88. 2008
    We previously used an integrative genetics approach to demonstrate that 5-lipoxygenase (5-LO) deficiency in mice (Alox5 (-/-)) protects against atherosclerosis despite increasing lipid levels and fat mass...
  18. ncbi Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells
    Alexandra I Medeiros
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Immunol 181:8544-51. 2008
    ..These data establish an important immunomodulatory role of LTs, in both the primary and secondary immune responses to histoplasmosis...
  19. pmc Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
    Yaoyu Chen
    Division of Hematology Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Nat Genet 41:783-92. 2009
    ..Here we identify the arachidonate 5-lipoxygenase (5-LO) gene (Alox5) as a critical regulator for leukemia stem cells (LSCs) in BCR-ABL-induced chronic myeloid leukemia (CML)...
  20. pmc Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury
    Alexander J Leedom
    Vision Science Program, School of Optometry, University of California, Berkeley, CA 94720 2020, USA
    Am J Pathol 176:74-84. 2010
    ..In summary, our findings and the prominent expression of 15-LOX and ALX in epithelial cells and macrophages place the LXA(4) circuit as an endogenous regulator of pathological angiogenesis...
  21. pmc Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow
    Tulio Queto
    Department of Pediatrics, Instituto Fernandes Figueira, Rio de Janeiro, Brazil
    J Leukoc Biol 87:885-93. 2010
    ..These findings provide evidence for: a) a novel role of eotaxin and IL-13 in regulating eosinophilopoiesis; and b) a role for CysLTRs in bone marrow cells in transducing cytokine regulatory signals...
  22. pmc Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, SPHI A Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Infect Immun 78:2264-71. 2010
    ..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia...
  23. doi 5-lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection
    Wander R Pavanelli
    Department of Biochemistry and Immunology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Microbes Infect 12:587-97. 2010
    ..cruzi infection. These results show that efficient parasite clearance is possible in a context of moderate inflammatory response, as occurred in 5-LO(-/-) mice, in which reduced myocarditis protects the animals during T. cruzi infection...
  24. pmc Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 5642, USA
    J Clin Invest 121:671-82. 2011
    ..These results uncover a pivotal role in macrophages for the GPCR BLT1 in regulating activation of NF-κB through Stat1-dependent expression of MyD88...
  25. pmc Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase
    Jin Chu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Pathol 178:1762-9. 2011
    ..They suggest that pharmacological inhibition of 5-LO could provide a novel therapeutic opportunity for AD...
  26. doi Leukotriene B4 mediates neutrophil migration induced by heme
    Ana Paula T Monteiro
    Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 186:6562-7. 2011
    ....
  27. pmc 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection
    Adriana Secatto
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    PLoS ONE 7:e31701. 2012
    ..Our results demonstrate that leukotrienes are required to control chronic fungal infection by amplifying both the innate and adaptive immune response during histoplasmosis...
  28. pmc LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells
    Cong Peng
    Division of Hematology Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e38614. 2012
    ..is reduced in CML mice, and depletion of leukemia stem cells (LSCs; BCR-ABL-expressing HSCs) by deleting Alox5 or by inhibiting heat shock protein 90 causes an increase in this LSK(-) population...
  29. pmc Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis
    C Henrique Serezani
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 189:906-15. 2012
    ..Our results identify LTB(4)-BLT1 signaling as an unrecognized controller of dectin-1 transcription via GM-CSF and PU.1 that is required for fungi-protective host responses...
  30. pmc 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease
    Jin Chu
    Center for Translational Medicine and Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    Ann Neurol 72:442-54. 2012
    The 5-lipoxygenase (5LO) enzyme is upregulated in Alzheimer disease (AD), and its genetic absence reduces Aβ levels in APP mice. However, its functional role in modulating tau neuropathology remains to be elucidated.
  31. pmc Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling
    Christian D Sadik
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:E3177-85. 2012
    ....
  32. pmc 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection
    Fabrine Sales Massafera Tristão
    Departamento de Bioquimica e Imunologia, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Infect Immun 81:1256-66. 2013
    ..Taken together, our results show for the first time that 5-LO enzymatic activity increases susceptibility to P. brasiliensis, suggesting that this pathway may be a potential target for therapeutic intervention during PCM...
  33. doi 5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1
    Seung Jin Lee
    Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, Gyeongnam, Korea
    Cardiovasc Res 99:724-33. 2013
    ....
  34. pmc Leukotriene B4 amplifies eosinophil accumulation in response to nematodes
    Michael L Patnode
    Department of Anatomy, Program in Biomedical Sciences, Howard Hughes Medical Institute, Department of Medicine, and Department of Pathology, University of California, San Francisco, San Francisco, CA 94143Department of Anatomy, Program in Biomedical Sciences, Howard Hughes Medical Institute, Department of Medicine, and Department of Pathology, University of California, San Francisco, San Francisco, CA 94143
    J Exp Med 211:1281-8. 2014
    ..The similarity of the eosinophil responses to diverse nematode species suggests that conserved features of nematodes are recognized during parasite infection...
  35. ncbi Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility
    Carlos H Serezani
    Department of Immunology, Institute of Biomedical Science IV, University of Sao Paulo, Sao Paulo, Brazil
    J Immunol 177:3201-8. 2006
    ..amazonensis, identify relevant leishmanicidal mechanisms, and suggest that genetic variation in LTB4 synthesis might influence resistance and susceptibility patterns to infection...
  36. ncbi cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase
    X S Chen
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 270:17993-9. 1995
    ..These studies provide a global picture of the murine 5-lipoxygenase system and raise questions about the role of 5-lipoxygenase and leukotrienes within the nucleus...
  37. ncbi 5-lipoxygenase knockout mice exhibit a resistance to splanchnic artery occlusion shock
    Salvatore Cuzzocrea
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Shock 20:230-6. 2003
    ..Part of this effect may be due to inhibition of the expression of adhesion molecules and subsequent reduction of neutrophil-mediated cellular injury...
  38. ncbi Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan
    Free Radic Biol Med 35:997-1007. 2003
    ..Thus, these gathered data indicated the differential roles of 5-LO and COX-2 in leukocyte adhesion, infiltration, and H2O2 generation...
  39. doi 5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase
    Mi R Yun
    MRC for Ischemic Tissue Regeneration, Pusan National University, Busan, Korea
    Free Radic Res 44:742-50. 2010
    ..Altogether, these results suggest that 5-LO plays a critical role in HNE-induced ROS generation in murine macrophages through activation of NADPH oxidase...
  40. pmc Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help
    Tsutomu Nagashima
    Department of Pathology Sapporo Medical University School of Medicine, Sapporo, Japan
    Am J Pathol 178:222-32. 2011
    In this study, we report the unique role of arachidonate 5-lipoxygenase (Alox5) in the regulation of specific humoral immune responses...
  41. pmc 5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis
    Victoria A Blaho
    Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
    J Immunol 186:3076-84. 2011
    ..These results demonstrate that products of the 5-LO metabolic pathway are not required for the development of disease in all models of arthritis and that caution should be used when targeting 5-LO as therapy for inflammatory diseases...
  42. doi 5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1
    Jung Min Lee
    College of Pharmacy, Sookmyung Women s University, Seoul 140 742, Republic of Korea
    J Immunol 189:5284-92. 2012
    ..Taken together, the results of this study demonstrate that 5-LO is a key mediator of RANKL-induced osteoclast formation and possibly a novel therapeutic target for bone-resorption diseases...
  43. pmc Lipoxin A₄ and 15-epi-lipoxin A₄ protect against experimental cerebral malaria by inhibiting IL-12/IFN-γ in the brain
    Nathaniel Shryock
    Divisions of Cellular and Molecular Immunology and Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e61882. 2013
    ..These observations establish 5-LO/LXA4 as a host protective pathway and suggest a new therapeutic approach against human cerebral malaria (HCM). (255 words)...
  44. pmc Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles
    Jin Chu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e70991. 2013
    The 5-lipoxygenase (5LO) enzyme is widely distributed within the central nervous system...
  45. doi The influence of 5-lipoxygenase on cigarette smoke-induced emphysema in mice
    Emanuel Kennedy-Feitosa
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Biochim Biophys Acta 1840:199-208. 2014
    ..Our hypothesis is that the inhibition of 5-lipoxygenase (5-LO) production may be an important strategy to reduce inflammation, oxidative stress, and metalloproteinases in lung tissue resulting from cigarette smoke (CS)-induced emphysema...
  46. doi Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways
    Iván Ballesteros
    2 Depto de Farmacología, Facultad de Medicina, Universidad Complutense, Avda Complutense s n, 28040 Madrid, Spain
    J Leukoc Biol 95:587-98. 2014
    ..in experimental stroke has been explained by the inhibition of inflammatory genes, an action in which 5-LO, Alox5, is involved...
  47. doi Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes
    Susan Adel
    Institute of Biochemistry, Charite University Medicine Berlin Charité, CCO Building, Virchowweg 6, 10117 Berlin, Germany Electronic address
    Biochim Biophys Acta 1842:1460-6. 2014
    5-Lipoxygenase (ALOX5) plays a key role in the biosynthesis of pro-inflammatory leukotrienes whereas 15-lipoxygenases (ALOX15) have been implicated in the formation of pro-resolving eicosanoids (lipoxins, resolvins)...
  48. doi 5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia
    Jessica Roos
    Department of Hematology, Goethe University, Frankfurt, Germany
    Cancer Res 74:5244-55. 2014
    ..Cancer Res; 74(18); 5244-55. ©2014 AACR. ..
  49. pmc 5-Lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice
    Sharon Schilling Landgraf
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS, Rio de Janeiro, Rio de Janeiro, Brazil Instituto Federal de Educação, Ciência e Tecnologia, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 9:e107549. 2014
    ..Our results reveal that LTs have an important role in tubulointerstitial disease induced by albumin overload...
  50. pmc Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy
    Phillip F Giannopoulos
    Center for Translational Medicine Department of Pharmacology
    Biol Psychiatry 78:693-701. 2015
    ..However, no data are available as to whether 5-LO is elevated in human tauopathy or if it directly influences tau pathology in a relevant model of the disease...
  51. doi MicroRNA-674-5p/5-LO axis involved in autoimmune reaction of Concanavalin A-induced acute mouse liver injury
    Kunkai Su
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Toxicol Lett 258:101-7. 2016
    ..These findings suggest that miR-674-5p might be a negative regulator in 5-LO mediated autoimmune liver injury, representing a compelling avenue towards future therapeutic interventions. ..
  52. ncbi FcepsilonRI- and Fcgamma receptor-mediated production of reactive oxygen species by mast cells is lipoxygenase- and cyclooxygenase-dependent and NADPH oxidase-independent
    Emily J Swindle
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    J Immunol 179:7059-71. 2007
    ....
  53. doi HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages
    Seung J Lee
    Department of Pharmacology and BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626 870, Korea
    Cardiovasc Res 88:352-9. 2010
    ..To determine the potential role for HNE in 5-LO expression, the molecular mechanisms of 5-LO expression were evaluated in HNE-stimulated macrophages...
  54. doi Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice
    Jae Hoon Choi
    Laboratory of Cardiovascular Genomics, Division of Molecular Life Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemoon Gu, Seoul 120 750, Republic of Korea
    Atherosclerosis 212:146-52. 2010
    ..BHB-TZD treatment also reduced MMP-2 and MMP-9 expressions in aorta. In conclusion, BHB-TZD effectively attenuated atherosclerosis in mouse model, suggesting its therapeutic potential for atherosclerosis...
  55. doi Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas
    Ligia A Paiva
    Laboratory of Immunopharmacology, Institute Oswaldo Cruz, Manguinhos, Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1801:1341-8. 2010
    ....
  56. doi Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice
    Eric C Cheon
    Department of Surgery, Mount Sinai Hospital, University of Illinois College of Medicine, Chicago, Illinois, USA
    Cancer Res 71:1627-36. 2011
    ..acid metabolism has been implicated in colon carcinogenesis, but the role of hematopoietic 5-lipoxygenase (5LO) that may impact tumor immunity in development of colon cancer has not been explored...
  57. doi Genetic deletion of 5-lipoxygenase increases tumor-infiltrating macrophages in Apc(Δ468) mice
    Eric C Cheon
    Department of Surgery, Mount Sinai Hospital, University of Illinois College of Medicine, 1500 S California Ave, Chicago, IL 60608, USA
    J Gastrointest Surg 16:389-93. 2012
    ..The role of 5-lipoxygenase (5-LO) in colon cancer is unknown. Tumor-infiltrating macrophages, neutrophils, and mast cells have been shown to play important roles in colon tumorigenesis and are dependent on 5-LO for function...
  58. pmc A high-fat diet induces bone loss in mice lacking the Alox5 gene
    Phuong Le
    Center for Clinical and Translational Research, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074 7205, USA
    Endocrinology 153:6-16. 2012
    5-Lipoxygenase catalyzes leukotriene generation from arachidonic acid. The gene that encodes 5-lipoxygenase, Alox5, has been identified in genome-wide association and mouse Quantitative Trait Locus studies as a candidate gene for obesity ..
  59. pmc Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
    Jakob von Moltke
    Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California at Berkeley, Berkeley, California 94720, USA
    Nature 490:107-11. 2012
    ..Our results therefore identify eicosanoids as a previously unrecognized cell-type-specific signalling output of the inflammasome with marked physiological consequences in vivo...
  60. pmc Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability
    V P Chou
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neuroscience 228:73-82. 2013
    ....
  61. ncbi The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice
    C D Funk
    Stellar Chance Laboratories, University of Pennsylvania, Philadelphia 19104 6100, USA
    Biochim Biophys Acta 1304:65-84. 1996
  62. pmc Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses
    R S Byrum
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599 7248, USA
    J Exp Med 185:1065-75. 1997
    ....
  63. ncbi 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice
    C G Irvin
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA
    Am J Physiol 272:L1053-8. 1997
    ..We conclude that 5-lipoxygenase products are essential for the production of nonspecific airway reactivity in mice and suggest that 5-lipoxygenase products may be important in immunoglobulin formation...
  64. ncbi Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice
    J L Goulet
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    J Immunol 163:359-66. 1999
    Leukotrienes, the 5-lipoxygenase (5LO) products of arachidonic acid metabolism, have many proinflammatory actions that have been implicated in the pathogenesis of a variety of inflammatory diseases...
  65. pmc Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences
    Y Y Zhang
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Biochem J 351:697-707. 2000
    5-Lipoxygenase (5LO) catalyses the first two steps in the biosynthesis of leukotrienes, which are inflammatory mediators derived from arachidonic acid...
  66. ncbi Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice
    F Ichinose
    Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 88:832-8. 2001
    ..Taken together, these findings demonstrate that a 5-LO product, most likely a cysteinyl LT, contributes to the attenuation of HPV and to pulmonary injury after challenge with endotoxin...
  67. ncbi Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation
    Brahm H Segal
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Leukoc Biol 71:410-6. 2002
    ..5-Lipoxygenase-deficient (5LX(-/-)) and C5-deficient mice only generated about 50% as much peritoneal leukocytosis as wild-type mice following ..
  68. ncbi Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein
    Sandra M Jones
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
    J Biol Chem 277:38550-6. 2002
    ..Moreover, we suggest that another sequence that can mediate nuclear import of 5-lipoxygenase remains to be identified...
  69. ncbi Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    Margarete Mehrabian
    Department of Medicine, UCLA School of Medicine, Los Angeles, Calif 90095 1679, USA
    Circ Res 91:120-6. 2002
    ..These results indicate that 5-LO contributes importantly to the atherogenic process and they provide strong presumptive evidence that reduced 5-LO expression is partly responsible for the resistance to atherosclerosis in CON6 mice...
  70. ncbi 5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Restor Neurol Neurosci 20:15-20. 2002
    ..Moreover, the 5LOX pathway has been associated with the neurotoxicity of the prion peptide. 5LOX-deficient mice [5LOX(-); B6129S(Alox5tm1Fun)] and their controls (B6129SF2/J) have not been behaviorally characterized...
  71. ncbi Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog
    Hartmut Kuhn
    Institute of Biochemistry, Humboldt University Medical School Charité, Berlin, Germany
    Arterioscler Thromb Vasc Biol 23:1072-6. 2003
    ..Comparison of 5-lipoxygenase genomic sequences of B6 and CON6 mice indicated 2 conserved amino acid exchanges in the CON6 animals, but the functional impact of these mutations has not been defined...
  72. ncbi 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine, University Federico II, Napoli, Italy
    J Leukoc Biol 73:739-46. 2003
    ..Taken together, our results clearly demonstrate that 5-LO modulates neutrophil infiltration in the acute lung inflammation...
  73. pmc Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity
    Ming Luo
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12165-70. 2003
    ..These results unequivocally demonstrate that the positioning of 5-LO within the nucleus of resting cells is a powerful determinant of the capacity to generate LTB4 upon subsequent activation...
  74. ncbi Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase
    Mitchell R Emerson
    Department of Molecular and Integrative Physiology, Ralph L Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Brain Res 1021:140-5. 2004
    ..Continued analysis will provide insight into the endogenous LO-generated effectors that assist in tempering EAE...
  75. ncbi Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Pediatr Nephrol 20:255-60. 2005
    ..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure...
  76. ncbi Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis
    Claudia F Benjamim
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:1616-20. 2005
    ..They also suggest the possible therapeutic utility of targeting vascular events in sepsis with cysteinyl-LT blockade...
  77. ncbi 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions
    Rene Hennig
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 65:6011-6. 2005
    ..These findings provide evidence that 5-LOX plays a key role in the development of pancreatic cancer. Furthermore, the lipoxygenase pathway may be a target for the prevention of this devastating disease...
  78. ncbi Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}
    Antonietta Rossi
    Department of Experimental Pharmacology, L Califano, University of Naples Federico II, Naples, Italy
    J Leukoc Biol 78:985-91. 2005
    ..Thus, the balance between COX and 5-LO metabolites could be of great importance in controlling macrophage functions and consequently, inflammation and tumor promotion...
  79. ncbi Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis
    Eleuza R Machado
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    J Immunol 175:3892-9. 2005
    ....
  80. ncbi Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent
    R Stokes Peebles
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 175:8253-9. 2005
    ..These results elucidate the pathways by which COX inhibition exerts a critical effect of the pulmonary allergen-induced inflammatory response and confirm that COX products are important regulators of allergic inflammation...
  81. ncbi Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis
    Tianjiang Liao
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, Louisville, Kentucky, USA
    Invest Ophthalmol Vis Sci 47:1543-9. 2006
    ..To investigate the role of leukotriene B4 (LTB4) and its receptor BLT1 in the pathogenesis of mouse uveitis...
  82. ncbi Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages
    Claudio Canetti
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0642, USA
    J Leukoc Biol 79:1234-41. 2006
    ..These results identify a fundamental difference in Fc gammaR signaling between DCs and MØ, which may relate to the divergent, functional consequences of target ingestion in the two cell types...
  83. ncbi Arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits
    Malcolm A Lyons
    Circ Res 98:e66. 2006
  84. pmc Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
    Hong Qiu
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:8161-6. 2006
    ..The abundant expression of LTA4H and correlation with plaque instability identify LTA4H as a potential target for pharmacological intervention in treatment of human atherosclerosis...
  85. ncbi Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein E-deficient mice?
    Colin D Funk
    Department of Physiology, Queen s University, Kingston, ON K7L 3N6 Canada
    Ann N Y Acad Sci 1085:151-60. 2006
    ..We are currently exploring the potential mechanisms for 5-LO/LT involvement in aneurysm pathogenesis and if this pathway might come into play in other models such as induction by angiotensin II...
  86. ncbi Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock
    Ben Wielockx
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and University of Ghent, Ghent, Belgium
    J Immunol 178:5069-75. 2007
    ..Definition of a critical region of 13 Mb on chromosome 6 was the highest mapping resolution obtained. Further analysis of candidate genes may provide a powerful tool to control TNF-induced pathologies in humans...
  87. ncbi NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis
    Michael J Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    J Leukoc Biol 82:1585-91. 2007
    ..In view of the antimicrobial actions of LT, a reduction in LT synthetic capacity by AM from NADPH oxidase KO mice may contribute to the susceptibility of these animals to infection...
  88. pmc Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation
    Dejan M Nikolic
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 282:33405-11. 2007
    ..Together, our results identify a novel role for iPLA(2)-catalyzed AA release and its metabolism by 12/15-LOX in coupling SR-A-mediated macrophage adhesion to Rac and Cdc42 activation...
  89. ncbi Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2
    Ana T G Guerrero
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    J Leukoc Biol 83:122-30. 2008
    ..by the pretreatment with MK886 (1-9 mg/kg; LT synthesis inhibitor) as well as in 5-lypoxygenase-deficient mice (5LO(-/-)) or by the selective antagonist of the LTB(4) receptor (CP105696; 3 mg/kg)...
  90. pmc Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function
    Kevin M Vannella
    Immunology Graduate Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:7883-90. 2007
    ..These data provide mechanistic insight into the therapeutic benefit of leukotriene synthesis inhibitors and CysLT1 receptor antagonists in animal models of fibrosis...
  91. ncbi 5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL-10-/- mice
    Seiko Narushima
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 294:G477-88. 2008
    ..These studies demonstrate that 5-LO-derived leukotrienes are not required for the development or maintenance of spontaneous or NSAID-induced colonic inflammation in IL-10(-/-) mice...
  92. doi Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced by swim stress in wild-type but not in 5-lipoxygenase-deficient mice
    Svetlana Dzitoyeva
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Neural Transm (Vienna) 115:823-7. 2008
    ..The BDNF transcript IV decrease was attenuated by caffeic acid in wild-type but not in 5-LOX-deficient mice, suggesting a role for 5-LOX in BDNF regulation...
  93. doi Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice
    Marta López-Parra
    Department of Biochemistry and Molecular Genetics, Centro de Investigación Biomédica Esther Koplowitz CIBEK, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona 08036, Spain
    J Lipid Res 49:2513-23. 2008
    ..Taken together, these findings identify a novel steatogenic role for 5-LO in the liver through mechanisms involving the regulation of hepatic MTP activity and VLDL-TG and apoB secretion...
  94. pmc Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export
    Nicolas Flamand
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:306-13. 2009
    ..This action works in concert with nuclear import, which is regulated by phosphorylation on Ser-523, to determine the subcellular distribution of 5-LO, which in turn regulates leukotriene biosynthesis...
  95. doi Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection
    Carlos Artério Sorgi
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    J Immunol 182:4025-35. 2009
    ..These results demonstrate that Hc induces LB formation, an event correlated with eicosanoid production, and suggest a role for these lipid-enriched organelles in host defense during fungal infection...
  96. doi 5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease
    Celso Luiz Borges
    Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Parana, Brazil
    Immunol Lett 123:38-45. 2009
    ..e., host resistance to acute infection with T. cruziin vivo, but in the event of an infection also play an important part in erythrocyte oxidative stress, an NO-dependent effect...
  97. pmc Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    Amy S McKee
    Howard Hughes Medical Institute, Denver, CO 80206, USA
    J Immunol 183:4403-14. 2009
    ..These data suggest that activation of the inflammasome and the type 2 innate response orchestrated by macrophages and mast cells in vivo are not required for adjuvant effect of alum on endogenous T and B cell responses...
  98. pmc 5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells
    M Imbesi
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroscience 164:1531-7. 2009
    ..In addition, an increase in DNMT3a but not DNMT1 expression accompanies an increase of 5-LOX methylation during in vitro maturation...
  99. pmc Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy
    Mushfiquddin Khan
    Department of Pediatrics, Darby Children Research Institute, Medical University of South Carolina, Charleston, SC, USA
    J Lipid Res 51:1685-95. 2010
    ..In sum, through 5-LOX activation, VLCFA accumulation causes a lipotoxic response consistent with cALD brain pathology...
  100. doi Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase
    Esther Titos
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, IDIBAPS, CIBEK, University of Barcelona, Barcelona 08036, Spain
    Prostaglandins Other Lipid Mediat 92:54-61. 2010
    Five-lipoxygenase (5-LO) has been postulated as a pathogenic factor in liver injury. Indeed, Alox5, the gene coding for 5-LO, is heavily over-expressed in experimental liver disease, in which 5-LO inhibition consistently ameliorates ..
  101. pmc Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis
    Maziar Divangahi
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:751-8. 2010
    ..Our results explain why T cell priming in response to M. tuberculosis is delayed and emphasize the importance of early immunity...

Research Grants15

  1. CYTOKINE DYSFUNCTION AND LUNG 5LO METABOLISM IN AIDS
    Michael Coffey; Fiscal Year: 2002
    ..This proposal will further enhance our ability to correct this defect and help boost AM, PBM, and PMN defenses against opportunistic infections in the lung in HIV disease. ..
  2. FORM CELL APO (A)/LP(A) RECEPTOR--CLONING AND FUNCTION
    Ira Tabas; Fiscal Year: 2002
    ..The studies in this proposal will lead to the molecular identification of a novel cholesterol-induced receptor on foam cells and should provide important insight into the role of foam cell-apo(a)/Lp(a) interactions in atherogenesis. ..
  3. REACTIVE NITROGEN & CEREBRAL ISCHEMIC INJURY
    MUSH KHAN; Fiscal Year: 2003
    ....
  4. Conference on Cellular Biology of Atherosclerosis
    Ira Tabas; Fiscal Year: 2005
    ....
  5. Macrophage Death in Plaque Vulnerability
    Ira Tabas; Fiscal Year: 2005
    ..New insights in this area may suggest new therapeutic strategies to combat cardiovascular disease. ..
  6. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  7. INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGES
    IRA A TABAS; Fiscal Year: 2010
    ..abstract_text> ..
  8. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2003
    ....
  9. BIOCHEMISTRY/BIOLOGY OF 5-LIPOXYGENASE AND LEUKOTRIENES
    COLIN FUNK; Fiscal Year: 2003
    ..b>5LO is predicted to be a two-domain protein consisting of a N-terminal beta-barrel domain of unknown function and a C-..
  10. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  11. PGE2 Regulation of Allergic Inflammation in the Lung
    RAY PEEBLES; Fiscal Year: 2007
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. [unreadable] [unreadable]..
  12. Prostacyclin (PG12) Regulation of Respiratory Syncytial Virus (RS)induced Illness
    RAY PEEBLES; Fiscal Year: 2007
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  13. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    Marc Peters Golden; Fiscal Year: 2008
    ..EP4 ligation. These proposed studies will provide fundamental insights into AM antimicrobial function, and a clinically relevant framework for understanding and modulating innate immunity in the lung. ..
  14. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
  15. Biology of Single Activity PGH Synthases
    COLIN FUNK; Fiscal Year: 2004
    ..Results obtained from this proposal should have broad implications for understanding mechanisms of human cancer and inflammatory disease. ..