Aldh1a7

Summary

Gene Symbol: Aldh1a7
Description: aldehyde dehydrogenase family 1, subfamily A7
Alias: AI987940, Ahd2-like, Aldh-pb, Aldh1a4, Aldhpb, aldehyde dehydrogenase, cytosolic 1, ALDH class 1, ALDH-E1, ALHDII, Aldehyde dehydrogenase 1 (phenobarbitol inducible), aldehyde dehydrogenase family 1 member A7, aldehyde dehydrogenase family 1, subfamily A4, aldehyde dehydrogenase phenobarbital-inducible, aldh1a7
Species: mouse

Top Publications

  1. pmc Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Biochem J 339:387-95. 1999
  2. pmc The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers
    Sarah K Harten
    BMC Biol 13:21. 2015
  3. pmc A paradoxical teratogenic mechanism for retinoic acid
    Leo M Y Lee
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
    Proc Natl Acad Sci U S A 109:13668-73. 2012
  4. pmc ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools
    Marilia Ioannou
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    Dev Biol 374:153-63. 2013
  5. ncbi Complementary domains of retinoic acid production and degradation in the early chick embryo
    E C Swindell
    Department of Biochemistry, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 216:282-96. 1999
  6. ncbi External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium
    Y Ogino
    Center for Animal Resources and Development, Kumamoto University, Japan
    Ann N Y Acad Sci 948:13-31. 2001
  7. ncbi The so-called "testis-specific aldehyde dehydrogenase" corresponds to type 2 retinaldehyde dehydrogenase in the mouse
    I Piotr Maly
    Institute of Anatomy, University of Basel, Pestalozzistrasse 20, Switzerland
    Histochem Cell Biol 119:169-74. 2003
  8. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
  9. pmc Host airway proteins interact with Staphylococcus aureus during early pneumonia
    Christy L Ventura
    Division of Infectious Diseases, Center for Childhood Infections and Prematurity Research, Seattle Children s Hospital Research Institute, 1900 9th Ave, Seattle, WA 98101, USA
    Infect Immun 76:888-98. 2008
  10. doi Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: implications for retinoid balance in gonad development
    Josephine Bowles
    Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    Dev Dyn 238:2073-80. 2009

Scientific Experts

  • I Piotr Maly
  • Kristopher R Schwab
  • Sarah K Harten
  • Marilia Ioannou
  • Leo M Y Lee
  • Julia Norden
  • Josephine Bowles
  • Boaz P Levi
  • Christy L Ventura
  • Lucia Daxinger
  • Luke Isbel
  • Jacqueline M Matthews
  • Lauren M Bourke
  • Vandhana Bharti
  • Harald Oey
  • Pierre Faou
  • Neil Robertson
  • Emma Whitelaw
  • Surendra Singh
  • Lori Sussel
  • Anthony Gavalas
  • Vasilis Vasiliou
  • Ioannis Serafimidis
  • Luis ArnĂ©s
  • Chun Yin Leung
  • Y Ogino
  • Alisa S W Shum
  • Walfred W C Tang
  • Heung Ling Choi
  • Chi Chiu Wang
  • Adrian S Woolf
  • Peter J McCaffery
  • Yun Chung Leung
  • Thomas Grieskamp
  • Marianne Petry
  • Christoph Englert
  • Mathilda T M Mommersteeg
  • Andreas Kispert
  • Karen Niederreither
  • Vincent M Christoffels
  • Maurice J B van den Hoff
  • Bram van Wijk
  • Ekkehart Lausch
  • Sean J Morrison
  • Peter Koopman
  • Gregg Duester
  • Vincent R Harley
  • Chun Wei Feng
  • Andrew H Sinclair
  • Omer H Yilmaz
  • Stefan Bagheri-Fam
  • Kelly N Roeszler
  • Craig A Smith
  • Deon Knight
  • Shawn J Skerrett
  • E C Swindell
  • L C Hsu
  • Eugene Kolker
  • Roger Higdon
  • Craig E Rubens
  • G Yamada
  • K Suzuki
  • Y Satoh
  • R Haraguchi
  • P Dolle
  • S Sockanathan
  • G Duester
  • W C Chang
  • M Petkovich
  • C Thaller
  • I Hoffmann
  • G Eichele
  • T M Jessell

Detail Information

Publications12

  1. pmc Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid
    L C Hsu
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Biochem J 339:387-95. 1999
    ..Thus our results indicate that Aldh1 can function in retinoic acid synthesis under physiological conditions, but that the closely related Aldh-pb does not share this property...
  2. pmc The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers
    Sarah K Harten
    BMC Biol 13:21. 2015
    ..To identify other loci affected by the absence of Rlf, we have now analysed 12 whole genome bisulphite sequencing datasets across three different embryonic tissues/stages from mice wild-type or null for Rlf...
  3. pmc A paradoxical teratogenic mechanism for retinoic acid
    Leo M Y Lee
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
    Proc Natl Acad Sci U S A 109:13668-73. 2012
    ..This previously undescribed and unsuspected mechanism provides insight into the molecular pathway of retinoic acid-induced teratogenesis...
  4. pmc ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools
    Marilia Ioannou
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
    Dev Biol 374:153-63. 2013
    ....
  5. ncbi Complementary domains of retinoic acid production and degradation in the early chick embryo
    E C Swindell
    Department of Biochemistry, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 216:282-96. 1999
    ..Localized regions of RA synthesis and degradation mediated by these two enzymes may therefore provide a mechanism to regulate RA homeostasis spatially in vertebrate embryos...
  6. ncbi External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium
    Y Ogino
    Center for Animal Resources and Development, Kumamoto University, Japan
    Ann N Y Acad Sci 948:13-31. 2001
    ..In RA-treated embryos, Fgf8 expression was still detected in the distal GT regions. Possible regulatory roles of the FGF and RA signaling systems in external genitalia formation are discussed...
  7. ncbi The so-called "testis-specific aldehyde dehydrogenase" corresponds to type 2 retinaldehyde dehydrogenase in the mouse
    I Piotr Maly
    Institute of Anatomy, University of Basel, Pestalozzistrasse 20, Switzerland
    Histochem Cell Biol 119:169-74. 2003
    ..The tissue distribution as well as substrate specificity and isoelectric points indicate that the "testis-specific aldehyde dehydrogenase" corresponds to mouse type 2 retinaldehyde dehydrogenase...
  8. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  9. pmc Host airway proteins interact with Staphylococcus aureus during early pneumonia
    Christy L Ventura
    Division of Infectious Diseases, Center for Childhood Infections and Prematurity Research, Seattle Children s Hospital Research Institute, 1900 9th Ave, Seattle, WA 98101, USA
    Infect Immun 76:888-98. 2008
    ..aureus in vivo. The data presented here provide novel insights into the host-pathogen interactions that occur when S. aureus enters the airway...
  10. doi Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: implications for retinoid balance in gonad development
    Josephine Bowles
    Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    Dev Dyn 238:2073-80. 2009
    ..Our data suggest that low levels of RA may be required for early developmental events in the testis, or that Aldh1a1 expression in the fetus may prefigure a later requirement for ALDH1A1 in regulating spermatogenesis postnatally...
  11. pmc Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns
    Julia Norden
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Circ Res 106:1212-20. 2010
    ..The systemic venous return myocardium (sinus node and sinus horns) forms only late in cardiogenesis from a pool of pericardial mesenchymal precursor cells...
  12. pmc Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems
    Boaz P Levi
    Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Blood 113:1670-80. 2009
    ..Finally, Aldh1a1 deficiency did not affect the function of stem cells from the adult central or peripheral nervous systems. Aldh1a1 is not a critical regulator of adult stem cell function or Aldefluor staining in mice...