Aldh1a1

Summary

Gene Symbol: Aldh1a1
Description: aldehyde dehydrogenase family 1, subfamily A1
Alias: Ahd-2, Ahd2, Aldh1, Aldh1a2, Raldh1, retinal dehydrogenase 1, ALDH-E1, ALHDII, RALDH 1, alcohol dehydrogenase family 1, subfamily A1, alcohol dehydrogenase family 1, subfamily A2, aldehyde dehydrogenase 1, liver cytosolic (class 1), aldehyde dehydrogenase family 1 member A1, aldehyde dehydrogenase, cytosolic
Species: mouse

Top Publications

  1. pmc Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis
    Nils O Lindström
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Gene Expr Patterns 11:221-32. 2011
  2. pmc Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development
    Florence Y Lee
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 21:315-27. 2011
  3. pmc Autocrine function of aldehyde dehydrogenase 1 as a determinant of diet- and sex-specific differences in visceral adiposity
    Rumana Yasmeen
    Department of Human Nutrition, The Ohio State University, Columbus, Ohio, USA
    Diabetes 62:124-36. 2013
  4. pmc beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region
    Dmitri Chilov
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS ONE 5:e10881. 2010
  5. pmc Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1)
    Francois Collard
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Biochimie 89:369-73. 2007
  6. ncbi Retinoic acid in the formation of the dorsoventral retina and its central projections
    E Wagner
    Eunice Kennedy Shriver Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Biol 222:460-70. 2000
  7. ncbi A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse
    H Li
    E Kennedy Shriver Center, Waltham, MA 02452, USA
    Mech Dev 95:283-9. 2000
  8. ncbi RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development
    F A Mic
    Gene Regulation Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 97:227-30. 2000
  9. ncbi Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Mech Dev 110:165-71. 2002
  10. pmc Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
    Xiaohong Fan
    OncoDevelopmental Biology Program Center for Neuroscience and Aging, Burnham Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:4637-48. 2003

Research Grants

Scientific Experts

  • D S Goldstein
  • CHINTHALAPALLY RAO
  • Alexander R Moise
  • Paola Sgadò
  • I Piotr Maly
  • Raymond Romand
  • Cheng Ji Zhou
  • Lars Olson
  • Nils O Lindström
  • Oliver Lieven
  • Gregg Duester
  • Frank M J Jacobs
  • Pascal Dolle
  • Nilima Prakash
  • Pierre Chambon
  • Gera Goverse
  • Florian W Kiefer
  • Karen Niederreither
  • Ouliana Ziouzenkova
  • Wolfgang Wurst
  • Marten P Smidt
  • Andrei Molotkov
  • Peter J McCaffery
  • Rumana Yasmeen
  • Kirsty D Shearer
  • Rosalie Molenaar
  • Reina E Mebius
  • Barbara Reichert
  • Brenda J Olivier
  • Marie Westerlund
  • Jorge Plutzky
  • Nicolas Matt
  • Annemarie J A van der Linden
  • J Peter H Burbach
  • Lars von Oerthel
  • Vasilis Vasiliou
  • Manuel Mark
  • Christine Dennefeld
  • Norbert B Ghyselinck
  • Natalie Lassen
  • Navid Nouri
  • U Krause
  • Valerie Fraulob
  • Marlene Knippenberg
  • Marie Paschaki
  • Simon R W Stott
  • Elizabeth C Wright-Jin
  • Marc Estienne Roehrich
  • R Yasmeen
  • George D McIlroy
  • Yang Yu
  • Jagan M R Patlolla
  • Fangping Yang
  • Mascha Greuter
  • Leo M Y Lee
  • Laurent Dollé
  • Maura Gasparetto
  • Shriram Nallamshetty
  • Jonathan D Brown
  • P McCaffery
  • Margaret Chia Ying Wey
  • Sanjay Rajagopalan
  • Mathilde Raverdeau
  • Hansjuerg Alder
  • Andreas Ratzka
  • Xiaoyan Li
  • Florence Y Lee
  • Ngome L Makia
  • S M Ulven
  • Joseph B Vella
  • Edwina Sutton
  • Giovanna Alfano
  • James E Crandall
  • David W Anderson
  • Robert O Heuckeroth
  • Goncalo Castelo-Branco
  • Dmitri Chilov
  • Michela Di Salvio
  • Molly Sharlach
  • Sebastian Stuebner
  • Sandeep Kumar
  • E Wagner
  • Gabriela Orasanu
  • Josephine Bowles
  • Serge A van de Pavert
  • Sue Ellen Touma
  • Maria Hörnberg
  • Boaz P Levi
  • Jiayi Huang
  • Joseph L Napoli

Detail Information

Publications117 found, 100 shown here

  1. pmc Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis
    Nils O Lindström
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Gene Expr Patterns 11:221-32. 2011
    ..This detailed study of the spatial and temporal expression of LIMK1 shows that LIMK1 expression is more dynamic than previously reported, in particular at sites of tissue-tissue interactions guiding multiple developmental processes...
  2. pmc Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development
    Florence Y Lee
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 21:315-27. 2011
    ..We conclude that the sumoylation cycle greatly expands the functional capacity of transcription factors such as SF-1 and is leveraged during development to achieve cell-type-specific gene expression in multicellular organisms...
  3. pmc Autocrine function of aldehyde dehydrogenase 1 as a determinant of diet- and sex-specific differences in visceral adiposity
    Rumana Yasmeen
    Department of Human Nutrition, The Ohio State University, Columbus, Ohio, USA
    Diabetes 62:124-36. 2013
    ..We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation...
  4. pmc beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region
    Dmitri Chilov
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS ONE 5:e10881. 2010
    ..These results highlight the role of beta-catenin in establishment of neuroectodermal signalling centers, promoting region-specific gene expression and regulation of cell fate determination...
  5. pmc Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1)
    Francois Collard
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Biochimie 89:369-73. 2007
    ..with the enzymatic activity in the last step indicated that it corresponded to aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme known to catalyze the oxidation of retinaldehyde to retinoic acid...
  6. ncbi Retinoic acid in the formation of the dorsoventral retina and its central projections
    E Wagner
    Eunice Kennedy Shriver Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Biol 222:460-70. 2000
    ..These observations indicate that the dorsoventral axis of the embryonic eye anlage determines the functional coordinates of both vision and eye movements in the adult...
  7. ncbi A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse
    H Li
    E Kennedy Shriver Center, Waltham, MA 02452, USA
    Mech Dev 95:283-9. 2000
    Most retinoic acid (RA) in the embryonic mouse is generated by three retinaldehyde dehydrogenases (RALDHs). RALDH1 (also called E1, AHD2 or ALDH1) is expressed in the dorsal retina, and RALDH2 (V2, ALDH11) generates most RA in the ..
  8. ncbi RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development
    F A Mic
    Gene Regulation Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 97:227-30. 2000
    ..The developmental expression patterns of two ALDHs that function as retinaldehyde dehydrogenases, RALDH1 and RALDH2, have been described...
  9. ncbi Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Mech Dev 110:165-71. 2002
    Three retinaldehyde dehydrogenases (RALDH1, RALDH2 and RALDH3), which catalyze the oxidation of retinaldehyde into retinoic acid, have been shown to be differentially expressed during early embryogenesis...
  10. pmc Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
    Xiaohong Fan
    OncoDevelopmental Biology Program Center for Neuroscience and Aging, Burnham Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:4637-48. 2003
    ..required for mouse retina development, controlled in part by an RA-generating aldehyde dehydrogenase encoded by Aldh1a2 (Raldh2) expressed transiently in the optic vesicles...
  11. ncbi Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid
    Andrei Molotkov
    OncoDevelopmental Biology Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:36085-90. 2003
    ..We now present genetic evidence that aldehyde dehydrogenase Aldh1a1, also known as retinaldehyde dehydrogenase Raldh1, plays a dominant role in the second step of retinol clearance ..
  12. ncbi Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice
    Merce Martin
    INSERM, U682, Strasbourg, France
    Dev Biol 284:399-411. 2005
    ..We conclude that RA synthesized in the mesenchyme is specifically required for the normal development of the dorsal pancreatic endoderm at a stage preceding Pdx 1 function...
  13. ncbi Tissue- and species-specific expression patterns of class I, III, and IV Adh and Aldh 1 mRNAs in rodent embryos
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, B2 4, 171 77 Stockholm, Sweden
    Cell Tissue Res 322:227-36. 2005
    ....
  14. ncbi Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells
    Nicolas Matt
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC Collège de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 132:4789-800. 2005
    ..is not the retina nor the corneal ectoderm, which both express RA-synthesizing retinaldehyde dehydrogenases (RALDH1 and RALDH3), but the neural crest cell-derived periocular mesenchyme (POM), which is devoid of RALDH...
  15. ncbi A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
    Nilima Prakash
    GSF National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Munich Neuherberg, Germany
    Development 133:89-98. 2006
    ..They also suggest the Wnt1-controlled signaling pathway as a promising target for new therapeutic strategies in the treatment of Parkinson's disease...
  16. pmc Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning
    Andrei Molotkov
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 133:1901-10. 2006
    ..Here, we report Raldh1, Raldh2 and Raldh3 single, double and triple null mice exhibiting progressively less or no RA synthesis in the eye...
  17. pmc Retinaldehyde represses adipogenesis and diet-induced obesity
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 13:695-702. 2007
    ..In vivo, mice lacking the Rald-catabolizing enzyme retinaldehyde dehydrogenase 1 (Raldh1) resisted diet-induced obesity and insulin resistance and showed increased energy dissipation...
  18. pmc Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, Rocky Mountain Lions Eye Institute, The Children s Hospital, University of Colorado, Denver, Colorado 80262, USA
    J Biol Chem 282:25668-76. 2007
    ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cornea but undetectable in the lens, and ALDH1A1 is present at lower (catalytic) levels in the cornea and lens...
  19. ncbi Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 134:2673-84. 2007
    ..We identified a developmental cascade in mice in which Ahd2 (Aldh1a1) is under the transcriptional control of Pitx3...
  20. pmc Retinoic acid induces prostatic bud formation
    Chad M Vezina
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA
    Dev Dyn 237:1321-33. 2008
    ..These observations suggest that reciprocal changes in hedgehog and BMP signaling by RA may regulate bud initiation...
  21. pmc Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes
    Cheng Ji Zhou
    Department of Cell Biology, School of Medicine, University of California, Davis, California, USA
    Dev Dyn 237:3681-9. 2008
    ..In addition, the retinoic acid synthesizing enzymes Raldh1 and Raldh3 were significantly changed in the mutant eyes...
  22. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009
    ....
  23. pmc Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model
    Sue Ellen Touma
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Biochem Pharmacol 78:1127-38. 2009
    ..RT-PCR to measure transcripts for genes involved in retinoid signaling and metabolism, including ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, LRAT, and RARbeta(2), in prostate tissue from TRAMP positive (+) and age-matched littermate ..
  24. doi Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
    Michela Di Salvio
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Nat Neurosci 13:1481-8. 2010
    ..These findings indicate that Otx2 is required to specify neuron subtype identity in VTA and may antagonize vulnerability to the Parkinsonian toxin MPTP...
  25. pmc Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation
    Ngome L Makia
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, United States
    Chem Biol Interact 191:278-87. 2011
    ..The catalytic efficiencies for metabolism of acrolein by Aldh1a1 was comparable to that of Aldh3a1 (V(max)/K(m)=23)...
  26. pmc Concerted action of aldehyde dehydrogenases influences depot-specific fat formation
    Barbara Reichert
    Department of Human Nutrition, Ohio State University, Columbus, Ohio, 43210, USA
    Mol Endocrinol 25:799-809. 2011
    ..The aldehyde dehydrogenase-1 (Aldh1) family of enzymes (Aldh1a1, a2, and a3) catalyzes RA production from retinaldehyde and thereby controls concentrations of this ..
  27. pmc Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system
    David W Anderson
    Dept of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Brain Res 1408:81-7. 2011
    Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a superfamily of detoxification enzymes found in various tissues that participate in the oxidation of both aliphatic and aromatic aldehydes...
  28. doi Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
    Frank M J Jacobs
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
    Development 138:5213-22. 2011
    ..of Ahd2-mediated RA signaling represents only one aspect of the Pitx3 downstream cascade, as Vmat2, Dat, Ahd2 (Aldh1a1), En1, En2 and Cck were unaffected by RA treatment and are (subset) specifically modulated by Pitx3...
  29. pmc Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism
    Florian W Kiefer
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Endocrinology 153:3089-99. 2012
    ..b>Aldh1a1-deficient mice are protected from diet-induced obesity and hence diabetes...
  30. pmc Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
    Florian W Kiefer
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:918-25. 2012
    ..Here we show that Aldh1a1 is expressed predominately in white adipose tissue (WAT), including visceral depots in mice and humans...
  31. pmc Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems
    Boaz P Levi
    Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Blood 113:1670-80. 2009
    ..This activity has been attributed to Aldh1a1, an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell ..
  32. ncbi A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci
    P Engler
    Department of Molecular Genetics and Cell Biology, University of Chicago
    Cell 65:939-47. 1991
    ..The pHRD transgene, containing target sequences for the V(D)J recombinase, undergoes site-specific recombination only in lymphoid tissues. This V-J joining is restricted primarily to unmethylated transgene copies...
  33. pmc Genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for multiple loci and localization of Ahd-2 on chromosome 19
    G P Timms
    Genetics 97:327-36. 1981
    ..Electrophoretic evidence for a third AHD isozyme (designated AHD-Cy), which is predominantly localized in the liver microsomal fraction, is also presented...
  34. ncbi Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens
    O A Bateman
    Birkbeck College, School of Crystallography, Malet Street, London WC1E 7HX, UK
    Biochemistry 42:4349-56. 2003
    ..It has a better-defined NAD binding site than those of related mammalian ALDH1 enzymes with the cofactor bound in the "hydride transfer" position in all four monomers with small differences ..
  35. ncbi Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development
    Nicolas Matt
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Dev Dyn 233:167-76. 2005
    ..Therefore, CRBP1 is required in prenatal life to maintain normal amounts of ROL and to ensure its efficient storage but seems of secondary importance for RA synthesis, at least under conditions of maternal vitamin A sufficiency...
  36. pmc Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex
    James E Crandall
    Eunice Kennedy Shriver Center for Mental Retardation, University of Massachusetts Medical School, Waltham, Massachusetts, USA
    J Neurochem 119:723-35. 2011
    ..These observations suggest functions of retinoic acid in interneuron diversity and organization of cortical excitatory-inhibitory balance...
  37. pmc MEK Is a Key Regulator of Gliogenesis in the Developing Brain
    Xiaoyan Li
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 75:1035-50. 2012
    ..We conclude that MEK is essential for acquisition of gliogenic competence by radial progenitors and that levels of MEK activity regulate gliogenesis in the developing cortex...
  38. pmc Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    J Neurochem 126:591-603. 2013
    ..these indices in transgenic mice with very low vesicular uptake VMAT2-Lo) or with knockouts of the genes encoding ALDH1A1 and ALDH2 (ALDH1A1,2 KO), applied these indices in PD putamen, and estimated the percent decreases in vesicular ..
  39. pmc Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function
    Elizabeth C Wright-Jin
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis 63110, MO, USA
    Dev Biol 381:28-37. 2013
    ..RA is produced by three different enzymes called retinaldehyde dehydrogenases (RALDH1, RALDH2 and RALDH3) that are all expressed in the developing bowel...
  40. pmc Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations
    R Yasmeen
    Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA
    Biochim Biophys Acta 1833:3218-27. 2013
    ..We provide evidence that the retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific splenic IgG1(+)/CD19(-) and IgG1(+)/CD19(+) B cell populations...
  41. doi Vitamin A metabolism and mucosal immune function are distinct between BALB/c and C57BL/6 mice
    Gera Goverse
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 45:89-100. 2015
    ..BALB/c mice were shown to have higher intestinal epithelial expression of RALDH1 (where RALDH is retinaldehyde dehydrogenase), and, consequently, higher RALDH activity in MLN-DCs, leading to an ..
  42. pmc Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors
    Navid Nouri
    Northwestern University, Feinberg Medical School, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Bldg, 303 E Superior Street, Chicago, IL 60611, USA Electronic address
    Mol Cell Neurosci 68:131-42. 2015
    ..Our findings will impact embryonic stem cell protocols that utilize Wnt pathway reagents to derive mDA neuron models and therapeutics for Parkinson's disease. ..
  43. ncbi A retinaldehyde dehydrogenase as a structural protein in a mammalian eye lens. Gene recruitment of eta-crystallin
    C Graham
    Section on Molecular Structure and Function, Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 2730, USA
    J Biol Chem 271:15623-8. 1996
    ..expression of recombinant eta-crystallin show that the protein is a cytoplasmic (class 1) aldehyde dehydrogenase (ALDH1, EC 1.2.1.3) with activity for the oxidation of retinaldehyde to retinoic acid...
  44. pmc Identification of SOX3 as an XX male sex reversal gene in mice and humans
    Edwina Sutton
    School of Molecular and Biomedical Science and Australian Research Council Special Research Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, South Australia, Australia
    J Clin Invest 121:328-41. 2011
    ..Together, these data suggest that SOX3 and SRY are functionally interchangeable in sex determination and support the notion that SRY evolved from SOX3 via a regulatory mutation that led to its de novo expression in the early gonad...
  45. pmc A paradoxical teratogenic mechanism for retinoic acid
    Leo M Y Lee
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
    Proc Natl Acad Sci U S A 109:13668-73. 2012
    ..This previously undescribed and unsuspected mechanism provides insight into the molecular pathway of retinoic acid-induced teratogenesis...
  46. pmc Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus
    George D McIlroy
    University of Aberdeen, College of Life Sciences and Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
    Diabetes 62:825-36. 2013
    ..Moreover, FEN induced RA-responsive genes in RALDH1 KO mice, demonstrating that FEN can augment RA signaling when RA synthesis is impaired...
  47. pmc Retinoic acid regulates olfactory progenitor cell fate and differentiation
    Marie Paschaki
    Laboratory for Sensory Development, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Neural Dev 8:13. 2013
    ....
  48. doi β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells
    Jagan M R Patlolla
    Center for Cancer Prevention and Drug Development, 975 NE 10th Street, BRC 1203, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 and Jagan M R Patlolla, E mail
    Cancer Prev Res (Phila) 6:1140-9. 2013
    ..Our findings suggest that β-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA/Rock signaling.
  49. doi Assessment of the risk of blastomere biopsy during preimplantation genetic diagnosis in a mouse model: reducing female ovary function with an increase in age by proteomics method
    Yang Yu
    Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, No 49 Huayuan Bei Road, Haidian District, Beijing 100191, China
    J Proteome Res 12:5475-86. 2013
    ..mice of the 23 differentially expressed proteins that were screened for in both groups, 3 proteins (PSMB8, ALDH1A1, and HSPA4) were selected and identified by Western blotting and quantitative RT-PCR methods, which showed the 3 ..
  50. pmc An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity
    U Krause
    1 Institute for Regenerative Medicine at Scott and White Hospital, Texas A and M Health Science Center, Module C, Temple, TX, USA 2 Department of Orthopaedics, Scott and White Hospital, Texas A and M Health Science Center College of Medicine, Temple, TX, USA
    Cell Death Dis 5:e1093. 2014
    ..in part to upregulation of the stress response enzyme and cancer stem cell marker aldehyde-dehydrogenase-1 (ALDH1)...
  51. doi Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice
    Laurent Dollé
    Liver Cell Biology Laboratory, Vrije Universiteit Brussels, Brussels, Belgium
    Hepatology 55:540-52. 2012
    ..b>ALDH1A1 expression can be detected in canals of Hering and bile duct epithelial cells and is increased on liver injury...
  52. pmc Murine and human myogenic cells identified by elevated aldehyde dehydrogenase activity: implications for muscle regeneration and repair
    Joseph B Vella
    Department of Orthopedic Surgery, Stem Cell Research Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e29226. 2011
    ..In this study, we hypothesized that elevated ALDH levels could identify murine and human muscle derived cell (hMDC) progenitors, endowed with enhanced stress resistance and muscle regeneration capacity...
  53. doi Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development
    Maura Gasparetto
    British Columbia Cancer Agency Terry Fox Laboratory, Vancouver, British Columbia, Canada
    Exp Hematol 40:318-29.e2. 2012
    High levels of the aldehyde dehydrogenase isoform ALDH1A1 are expressed in hematopoietic stem cells (HSCs); however, its importance in these cells remains unclear...
  54. pmc Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease
    Margaret Chia Ying Wey
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e31522. 2012
    ..To address this hypothesis, we generated mice null for Aldh1a1 and Aldh2, the two isoforms known to be expressed in substantia nigra dopamine neurons...
  55. doi Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo
    Andreas Ratzka
    Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany
    J Neurochem 122:94-105. 2012
    ..Increased levels of nuclear FgfR1 in E14.5 FGF-2-deficient mice suggest alterations of integrative nuclear FgfR1 signaling (INFS). In summary, FGF-2 restricts SNpc DA neurogenesis in vivo during late stages of embryonic development...
  56. pmc The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Trento, Italy
    Neural Dev 7:24. 2012
    ....
  57. doi Astrocytes as a regulated source of retinoic acid for the brain
    Kirsty D Shearer
    Translational Neuroscience, Institute of Medical Sciences, School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Glia 60:1964-76. 2012
    ..Similarly, in conditions of oxidative stress RALDH1 and RALDH2 moved from the cytoplasm to a predominantly nuclear position...
  58. pmc Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis
    Mathilde Raverdeau
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale Unité 964, Universite de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 109:16582-7. 2012
    ....
  59. pmc Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity
    Marc Estienne Roehrich
    Department of Cardiology, Centre Hospitalier Universitaire Vaudois CHUV, avenue du Bugnon, 1011 Lausanne, Switzerland
    Biomed Res Int 2013:503047. 2013
    ..b>ALDH1A2 expression was highest in ALDH(very-br) cells, intermediate in ALDH(dim) cells, and lowest in ALDH(br) cells...
  60. doi Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages
    Simon R W Stott
    Developmental Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 33:8022-34. 2013
    ..These results extend previous findings and demonstrate a later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mDA neurons...
  61. ncbi Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: localization of Ahd-1 encoding the mitochondrial isozyme on chromosome 4
    R S Holmes
    Biochem Genet 16:1207-18. 1978
    ..Ontogenetic analyses demonstrated that both AHD isozymes exhibited low activity in late fetal and early neonatal liver and kidney extracts, and reached adult levels within 3 weeks of birth...
  62. ncbi Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina
    P McCaffery
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115
    Development 115:371-82. 1992
    ....
  63. ncbi Aldehyde dehydrogenase is a positional marker in the retina
    P McCaffery
    Department of Neurobiology, Harvard Medical School Boston, MA 02115
    Development 112:693-702. 1991
    ....
  64. ncbi Isolation and characterization of a cytosolic aldehyde dehydrogenase-encoding cDNA from mouse liver
    P Rongnoparut
    Department of Biological Sciences, University of Illinois, Chicago 60680
    Gene 101:261-5. 1991
    ..The sequence of a 700-bp genomic fragment containing the first exon and 546 bp of 5'-flanking DNA was determined. TATA and CCAAT motifs are located 31 and 73 bp, respectively, from the major tsp...
  65. ncbi Studies with cDNA probes on the in vivo effect of ethanol on expression of the genes of alcohol metabolism
    S L Bond
    Department of Zoology, University of Western Ontario, London, Canada
    Alcohol Alcohol 25:385-94. 1990
    ....
  66. ncbi A gene for susceptibility to small intestinal cancer, ssic1, maps to the distal part of mouse chromosome 4
    R J Fijneman
    The Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam, The Netherlands
    Cancer Res 55:3179-82. 1995
    ..This difference is highly significant (chi 2 = 31 for D4Mit158). Therefore, one of the genes that influence susceptibility to small intestinal cancer, ssic1, maps to the distal part of chromosome 4...
  67. ncbi The retinal outer segment membrane protein-1 gene (Rom1) maps to the proximal end of mouse chromosome 19
    B A Taylor
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 23:510-1. 1994
  68. ncbi Cloning and characterization of the gene encoding mouse mitochondrial aldehyde dehydrogenase
    C Chang
    Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    Gene 148:331-6. 1994
    ..Northern blot hybridization demonstrated the existence of a high level of mALDH2 mRNA in mouse liver and a low level in mouse kidney...
  69. ncbi DNA sequence analysis of the cytosolic acetaldehyde dehydrogenase gene (Ahd-2) in mouse strains with variable ethanol preferences
    S L Bond
    Department of Zoology, University of Western Ontario, London, Canada
    Biochem Med Metab Biol 52:155-9. 1994
    ..These differences cannot explain their variable ethanol preference and the implications of sequence identities among the divergent strains in these regions has yet to be determined...
  70. ncbi Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases
    M Chen
    Department of Pharmacology, Cornell University Medical College, New York, New York 10021
    Mol Pharmacol 46:88-96. 1994
    ..AHD-2 is more active than AHD-M1 in this conversion, but AHD-2 is not the enzyme responsible for this conversion in F9 embryonic stem cells...
  71. ncbi Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11
    K Huppi
    Laboratory of Genetics, NCI NIH, Bethesda, MD 20892
    Immunogenetics 37:288-91. 1993
  72. ncbi Dopamine neuron agenesis in Nurr1-deficient mice
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Science 276:248-50. 1997
    ..These results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry...
  73. ncbi The cytosolic aldehyde dehydrogenase gene (Aldh1) is developmentally expressed in Leydig cells
    L A Lopez-Fernandez
    Department of Cell and Developmental Biology, Centro de Investigaciones Biologicas C S I C, Velazquez, Madrid, Spain
    FEBS Lett 407:225-9. 1997
    Cytosolic aldehyde dehydrogenase, ALDH1, participates in the oxidation of different aldehydes including that of all-trans retinal to retinoic acid...
  74. pmc The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development
    W K Greene
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Cell Biol 18:7030-7. 1998
    ..The gene encoding the retinoic acid-synthesizing enzyme aldehyde dehydrogenase 1 (Aldh1), initially called Hdg-1, was found to be ectopically activated by HOX11 in this system...
  75. ncbi Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitf-vit mouse model of retinal degeneration
    T Duncan
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Vis 5:9. 1999
    ..An additional purpose was to examine the expression of the RA generating enzyme, retinaldehyde dehydrogenase (AHD2), in the eyes of mutant and control mice.
  76. ncbi Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression
    P McCaffery
    E Kennedy Shriver Center, Waltham, MA 02452, USA
    Mech Dev 85:203-14. 1999
    ....
  77. pmc Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Dev Genet 25:353-64. 1999
    ..Here we show that injection of Xenopus embryos with mRNAs for either mouse Aldh1 or mouse Raldh2 stimulates RA synthesis at low and high levels, respectively, while injection of human ALDH3 mRNA ..
  78. ncbi Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid
    S M Ulven
    Institute for Nutrition Research, University of Oslo, Blindern, Oslo, 0316, Norway
    Dev Biol 220:379-91. 2000
    ..Therefore, our results suggest that RALDH2 is a key regulator in initiating retinoic acid synthesis sometime between the mid-primitive streak stage and the late allantoic bud stage in mouse embryos...
  79. ncbi Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina
    R Suzuki
    Division of Molecular Neurobiology, National Institute for Basic Biology, Department of Molecular Biomechanics, The Graduate University for Advanced Studies, 38 Nishigonaka, Myodaiji cho, Okazaki, Japan
    Mech Dev 98:37-50. 2000
    ..These results suggested that Raldh-3 is the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development, and also in the development of the olfactory system...
  80. ncbi Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally
    S M Ulven
    Institute for Nutrition Research, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway
    Dev Dyn 222:341-53. 2001
    ..It sets definite limits on how much 9-cis-RA potentially is present and demonstrates that at-RA predominates over 9-cis-RA by at least 30- to 180-fold in different spinal cord regions...
  81. ncbi cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells
    Run Zhuang
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 3104, USA
    Biochemistry 41:3477-83. 2002
    ..production in intact cells, in conjunction with each of three retinal dehydrogenases that recognize 9-cis-retinal (RALDH1/AHD2, RALDH2, and ALDH12)...
  82. pmc Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice
    Felix A Mic
    Gene Regulation Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 129:2271-82. 2002
    ..allows development to proceed and results in the establishment of additional sites of RA synthesis linked to Raldh1 expression in the dorsal retina and to Raldh3 expression in the ventral retina, olfactory pit and urinary tract...
  83. ncbi Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos
    Ujjwal Kumar Rout
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 East Hancock, Detroit, MI 48201, USA
    Reprod Toxicol 16:253-8. 2002
    ..The absence of enzymes to convert ethanol to acetaldehyde, coupled with oocyte expression of the acetaldehyde-degrading enzyme, Ahd-5, may be protective for the early embryo...
  84. pmc Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche ScientifiqueInstitut National de la Santé et de la Recherche MédicaleUniversité Louis PasteurCollège de France, Strasbourg, France
    Proc Natl Acad Sci U S A 99:16111-6. 2002
    ..mouse embryos and investigated whether these activities could be ascribed to the other known RALDH enzymes (RALDH1 and RALDH3)...
  85. ncbi Cloning of monkey RALDH1 and characterization of retinoid metabolism in monkey kidney proximal tubule cells
    Helene Brodeur
    Laboratory of Nutrition and Cancer, Universite de Montreal, Montreal, Quebec, Canada
    J Lipid Res 44:303-13. 2003
    ..We have previously characterized and cloned from kidney tissues the rat retinal dehydrogenase type 1 (RALDH1), which oxidizes all-trans and 9-cis retinal with high efficiency but is inactive with 13-cis retinal...
  86. ncbi The so-called "testis-specific aldehyde dehydrogenase" corresponds to type 2 retinaldehyde dehydrogenase in the mouse
    I Piotr Maly
    Institute of Anatomy, University of Basel, Pestalozzistrasse 20, Switzerland
    Histochem Cell Biol 119:169-74. 2003
    ..The tissue distribution as well as substrate specificity and isoelectric points indicate that the "testis-specific aldehyde dehydrogenase" corresponds to mouse type 2 retinaldehyde dehydrogenase...
  87. ncbi CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development
    Yasuo Sakai
    Eunice Kennedy Shriver Center at the University of Massachusetts Medical School, Waltham, MA, USA
    Dev Biol 276:143-57. 2004
    ..The safeguard of the RA-poor stripe by two distinct enzymes during later development points to a role in maturation of a significant functional feature like an area of higher visual acuity that develops at its location...
  88. ncbi Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation
    Takako Makita
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 280:59-72. 2005
    ..5 onward is enhancer-independent, and is driven instead by basal promoter elements that provide a sufficient level of expression to support further erythropoietic differentiation...
  89. ncbi Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
    Lachlan H Thompson
    Wallenberg Neuroscience Center, Department of Experimental Medical Science, and Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 198:183-98. 2006
    ..The Ngn2-GFP reporter construct used here thus provides a tool for the identification of mesDA neuron precursors in the VM and selective isolation of transplantable mesDA neuron precursors for transplantation...
  90. ncbi Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
    Alcohol Clin Exp Res 30:1659-69. 2006
    ..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains...
  91. ncbi High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS J 274:1212-23. 2007
    ..We investigated cellular expression of Adh1, Adh3, Adh4 and Aldh1 mRNA along the rodent GI tract...
  92. pmc The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
    Raja Kittappa
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 5:e325. 2007
    ..Manipulating forkhead function may regulate both the birth of dopamine neurons and their spontaneous death, two major goals of regenerative medicine...
  93. doi Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons
    Chao Guo
    Institute of Neuroscience, Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 28:14097-106. 2008
    ..Thus, our results indicate that the inductive activity of IsO is essential, but Lmx1b expression in mDA neurons is dispensable for their differentiation and maintenance...
  94. doi Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: implications for retinoid balance in gonad development
    Josephine Bowles
    Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    Dev Dyn 238:2073-80. 2009
    ..We report here that the gene encoding a cytosolic class-1 aldehyde dehydrogenase, ALDH1A1, a weak catalyst of RA production, is strongly expressed in a male-specific manner in somatic cells of the ..
  95. pmc Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
    Serge A van de Pavert
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 10:1193-9. 2009
    ..Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons...
  96. doi Delayed dopaminergic neuron differentiation in Lrp6 mutant mice
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Dev Dyn 239:211-21. 2010
    ..5. Our results, therefore, suggest a role for Lrp6 in the onset of DA neuron development in the VM as well as a role in midbrain morphogenesis...
  97. doi Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect
    Sebastian Stuebner
    Institute of Developmental Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, and Technical University Munich, Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Munich Neuherberg, Germany
    Dev Dyn 239:246-60. 2010
    ..Fzd3 and Fzd6 thus control proper midbrain morphogenesis by a yet unknown mechanism in the mouse...
  98. pmc Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2
    Sandeep Kumar
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, California 92037, USA
    Dev Biol 340:67-74. 2010
    ..Genetic studies using Raldh1/Raldh3 double null mice deficient for ocular RA synthesis demonstrated that Pitx2 and Dkk2 were both down-..
  99. doi Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye
    Giovanna Alfano
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    Development 138:261-71. 2011
    ..These data demonstrate for the first time that Vax2 is both necessary and sufficient for the control of intraretinal RA metabolism, which in turn contributes to the appropriate expression of cone opsins in the vertebrate eye...
  100. doi Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A
    Rosalie Molenaar
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Immunol 186:1934-42. 2011
    ..Our results show that RA-dependent signaling within the intestine is indispensable for RALDH activity in the draining MLN...

Research Grants3

  1. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  2. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2008
    ..abstract_text> ..
  3. Parkinsonian mouse model: impaired respiratory enzymes
    Lars Olson; Fiscal Year: 2005
    ..2. To determine if respiratory chain dysfunction in DA neurons will induce a PD like phenotype and validate this approach as a new and unique model of Parkinson's Disease. ..