Aim2

Summary

Gene Symbol: Aim2
Description: absent in melanoma 2
Alias: Gm1313, Ifi210, interferon-inducible protein AIM2, ifi-210, interferon-inducible protein 210, interferon-inducible protein p210
Species: mouse

Top Publications

  1. doi HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    Tara L Roberts
    The University of Queensland, Institute for Molecular Bioscience, QLD 4072, Australia
    Science 323:1057-60. 2009
  2. pmc Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
    Rebecca L Brunette
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 209:1969-83. 2012
  3. pmc AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
    R Pierini
    Universite de Lyon, France
    Cell Death Differ 19:1709-21. 2012
  4. pmc Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:255-63. 2012
  5. doi Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
  6. pmc Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    Kiichi Nakahira
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:222-30. 2011
  7. doi Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes
    Kohsuke Tsuchiya
    Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Immunol 185:1186-95. 2010
  8. pmc Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 185:818-21. 2010
  9. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010
  10. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009

Scientific Experts

  • Nobuhiko Kayagaki
  • David Brough
  • Chong Shan Shi
  • Veit Hornung
  • Kohsuke Tsuchiya
  • Katherine A Fitzgerald
  • Ravichandran Panchanathan
  • Si Ming Man
  • Vijay A K Rathinam
  • Rajendra Karki
  • Thirumala Devi Kanneganti
  • Divaker Choubey
  • R K Subbarao Malireddi
  • Prajwal Gurung
  • Teresa Fernandes-Alnemri
  • Mohamed Lamkanfi
  • Peter Vogel
  • Thomas Henry
  • Jianghong Wu
  • Geoffrey Neale
  • Masahiro Yamamoto
  • Parisa Kalantari
  • Petr Broz
  • Zhiping Liu
  • C Juruj
  • Eran Elinav
  • Sivapriya Kailasan Vanaja
  • R Pierini
  • Jasmyn A Cridland
  • Eicke Latz
  • Katryn J Stacey
  • Loren D Erickson
  • Xin Duan
  • Hui Shen
  • Tara L Roberts
  • Emad S Alnemri
  • Elizabeth E Gray
  • Xiaopeng Qi
  • Nastaran Mohammadi
  • Bo Hu
  • Leticia Corrales
  • Antonia Di Micco
  • Hyo Yeon Kim
  • Christopher Jakobs
  • Man Lyang Kim
  • Justin E Wilson
  • Jeremy Dupaul-Chicoine
  • Etienne Meunier
  • Rebecca Baum
  • Adam Denes
  • Xianhui Hou
  • John J Suschak
  • Fan Yang
  • Richa Hanamsagar
  • Daniel B Stetson
  • Richard A Flavell
  • Till Strowig
  • Stephanie C Eisenbarth
  • Jorge Henao-Mejia
  • Marco Túlio R Gomes
  • V Sagulenko
  • Fayyaz S Sutterwala
  • Weijuan Zhang
  • Tyler K Ulland
  • Roberto Pierini
  • Qian Yin
  • Swati Shah
  • T Henry
  • Shruti Sharma
  • M Perret
  • Rebecca L Brunette
  • Michael Wenzel
  • Min Woo Sung
  • Elizabeth A Creasey
  • Kenichi Shimada
  • Hiroyuki Saiga
  • Kamila Belhocine
  • Jianning Ge
  • Stefanie N Vogel
  • Hongzhu Liu
  • Kiichi Nakahira
  • Denise M Monack
  • Matthew J Sweet
  • Jonathan W Jones
  • Sarah Kim
  • Sarah E Warren
  • John Demian Sauer
  • Je Wook Yu
  • Pinaki Datta
  • Tilmann Burckstummer

Detail Information

Publications65

  1. doi HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    Tara L Roberts
    The University of Queensland, Institute for Molecular Bioscience, QLD 4072, Australia
    Science 323:1057-60. 2009
    ..Conversely, the related pyrin domain-containing HIN-200 factor, AIM2 (p210), was required for caspase activation by cytoplasmic dsDNA...
  2. pmc Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
    Rebecca L Brunette
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 209:1969-83. 2012
    ..Certain members of the AIM2-like receptor (ALR) gene family contribute to each of these pathways, but most ALRs remain uncharacterized...
  3. pmc AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
    R Pierini
    Universite de Lyon, France
    Cell Death Differ 19:1709-21. 2012
    ..Caspase-1 causes pyroptosis, a necrotic-like cell death. AIM2 is an inflammasome sensor for cytosolic DNA. The adaptor molecule ASC mediates AIM2-dependent caspase-1 activation...
  4. pmc Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:255-63. 2012
    ..Here we show that the induction of AIM2 or NLRP3 inflammasomes in macrophages triggered activation of the G protein RalB and autophagosome formation...
  5. doi Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
    ..These data highlight a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections...
  6. pmc Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    Kiichi Nakahira
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:222-30. 2011
    ..Our study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondrial integrity...
  7. doi Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes
    Kohsuke Tsuchiya
    Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Immunol 185:1186-95. 2010
    ..In this study, we demonstrate the role of absent in melanoma 2 (AIM2), a recently described receptor of cytosolic DNA, in the activation of caspase-1 upon infection with L...
  8. pmc Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 185:818-21. 2010
    ..We now use biochemical and genetic approaches to demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that has previously been shown to detect viral DNA.
  9. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010
    ..Here, we show that macrophages from mice lacking absent in melanoma 2 (AIM2) cannot sense cytosolic double-stranded DNA and fail to trigger inflammasome assembly...
  10. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
    ..cells, here we identify the PYHIN (pyrin and HIN domain-containing protein) family member absent in melanoma 2 (AIM2) as a receptor for cytosolic DNA, which regulates caspase-1...
  11. pmc The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Immunol 11:385-93. 2010
    ..Using mice deficient in the DNA-sensing inflammasome component AIM2, we demonstrate here that AIM2 is required for sensing F. tularensis...
  12. pmc The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 11:395-402. 2010
    Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1beta (IL-1beta) and IL-18. AIM2 has been shown to bind DNA and engage the caspase-1-activating adaptor protein ASC to form a caspase-1-activating ..
  13. pmc Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol
    John Demian Sauer
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3202, USA
    Cell Host Microbe 7:412-9. 2010
    ..Nlrp3 and Nlrc4 inflammasome receptors but dependent on the inflammasome adaptor ASC and the cytosolic DNA sensor AIM2. Importantly, wild-type L...
  14. pmc AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 458:509-13. 2009
    ..The nature of the cytoplasmic-DNA-sensing inflammasome is currently unknown. Here we show that AIM2 (absent in melanoma 2), an interferon-inducible HIN-200 family member that contains an amino-terminal pyrin domain ..
  15. doi Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion
    Hyo Yeon Kim
    School of Pharmacy, Sungkyunkwan University, Suwon, Korea
    FEBS J 282:259-70. 2015
    ..domain leucine-rich repeat containing family pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes and the subsequent serum release of interleukin 1β...
  16. pmc Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection
    Rajendra Karki
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 17:357-68. 2015
    ..We show that two inflammasome receptors, AIM2 and NLRP3, recognize intracellular A. fumigatus and collectively induce protective immune responses...
  17. doi MicroRNA-223 acts as an important regulator to Kupffer cells activation at the early stage of Con A-induced acute liver failure via AIM2 signaling pathway
    Fan Yang
    State Key Laboratory of Infectious Diseases Diagnosis and Treatment, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
    Cell Physiol Biochem 34:2137-52. 2014
    ..Present study aimed to discover the potential regulator and explore deeper information of Kupffer cells activation at the early stage of ALF...
  18. pmc Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice
    Rebecca Baum
    Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605
    J Immunol 194:873-7. 2015
    ..in DNase II/IFNaR together with deficiency in either stimulator of IFN genes (STING) or absent in melanoma 2 (AIM2), we reveal central roles for the STING and AIM2 pathways in arthritis...
  19. ncbi The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
    Bo Hu
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 354:765-768. 2016
    ..Here, we show that mice deficient in the double-stranded DNA sensor AIM2 are protected from both subtotal body irradiation-induced gastrointestinal syndrome and total body irradiation-..
  20. pmc Identification of Aim2 as a sensor for DNA vaccines
    John J Suschak
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655 and
    J Immunol 194:630-6. 2015
    ..signaling molecules in the innate immune system, the current study investigated the role of absent in melanoma 2 (Aim2) as a sensor for DNA vaccines...
  21. pmc AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, 1083, Hungary Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and
    Proc Natl Acad Sci U S A 112:4050-5. 2015
    ..Here, using a rodent model of stroke, we show that the NLRC4 (NLR family, CARD domain containing 4) and AIM2 (absent in melanoma 2) inflammasomes contribute to brain injury...
  22. pmc Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome
    Sivapriya Kailasan Vanaja
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111 Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 and
    Proc Natl Acad Sci U S A 111:7765-70. 2014
    ..Collectively, these findings identify RNA:DNA hybrids of bacterial origin as a unique microbial trigger of the NLRP3 inflammasome. ..
  23. pmc Critical role for the AIM2 inflammasome during acute CNS bacterial infection
    Richa Hanamsagar
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Neurochem 129:704-11. 2014
    ..suggesting the involvement of an alternative upstream sensor, which was later identified as absent in melanoma 2 (AIM2) based on the similar disease patterns between AIM2 and ASC KO mice...
  24. pmc Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria
    Parisa Kalantari
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 6:196-210. 2014
    ..Finally, infected erythrocytes activated both the NLRP3 and AIM2 inflammasomes...
  25. doi ASC controls IFN-γ levels in an IL-18-dependent manner in caspase-1-deficient mice infected with Francisella novicida
    Roberto Pierini
    Centre International de Recherche en Infectiologie, Universite de Lyon, Lyon 69007, France
    J Immunol 191:3847-57. 2013
    ..During F. tularensis subspecies novicida infection, AIM2, an inflammasome receptor sensing cytosolic DNA, activates caspase-1 in an ASC-dependent manner, leading to both ..
  26. doi Noncanonical inflammasome activation by intracellular LPS independent of TLR4
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Science 341:1246-9. 2013
    ..coli LPS. These data unveil a TLR4-independent mechanism for innate immune recognition of LPS. ..
  27. pmc The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
    Si Ming Man
    1 Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia
    Nat Immunol 16:467-75. 2015
    ..The molecular mechanisms that control activation of the AIM2 inflammasome in response to different cytosolic pathogens remain unclear...
  28. pmc Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida
    Etienne Meunier
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    Nat Immunol 16:476-84. 2015
    The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-1-dependent pyroptosis as well as release of the inflammatory cytokines interleukin 1β (IL-1β) and IL-18...
  29. doi The NMR solution structure of AIM2 PYD domain from Mus musculus reveals a distinct α2-α3 helix conformation from its human homologues
    Xianhui Hou
    Beijing Nuclear Magnetic Resonance Center, Peking University, Beijing, China College of Chemistry and Molecular Engineering, Peking University, Beijing, China
    Biochem Biophys Res Commun 461:396-400. 2015
    ..Cytosolic protein absent in melanoma 2 (AIM2) has been reported to play an essential role in double-stranded DNA (dsDNA) sensing and inflammasome formation in ..
  30. pmc Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
    Man Lyang Kim
    Division of Inflammation, Division of Cancer and Hematology, Division of Immunology, and ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 212:927-38. 2015
    ..Previously, perturbation of actin polymerization by pathogens was shown to activate the pyrin inflammasome, so our data now extend this guard hypothesis to host-regulated actin-dependent processes and autoinflammatory disease. ..
  31. pmc Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 162:45-58. 2015
    Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune sensor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown...
  32. pmc Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
    Xiaopeng Qi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Exp Med 213:2081-97. 2016
    ..Our results identified a fundamental biological function of cathepsin B in providing a checkpoint for homeostatic maintenance of lysosome populations and basic recycling functions in the cell. ..
  33. pmc Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt
    Justin E Wilson
    1 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA 2 Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA 3 Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA
    Nat Med 21:906-13. 2015
    ..The absent in melanoma 2 (AIM2) inflammasome is activated by double-stranded DNA, and AIM2 expression is reduced in several types of cancer, but ..
  34. pmc AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis
    Christopher Jakobs
    Institute of Molecular Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany
    PLoS ONE 10:e0131702. 2015
    ..To this end, we studied the role of the DNA-sensing inflammasome receptor AIM2 in this self-DNA driven disease model...
  35. doi The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity
    Jeremy Dupaul-Chicoine
    Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada
    Immunity 43:751-63. 2015
    ..Our results define a regulatory signaling circuit within the innate immune system linking inflammasome activation to effective NK-cell-mediated tumor attack required to suppress colorectal cancer growth in the liver...
  36. pmc Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA
    Leticia Corrales
    Department of Pathology, The University of Chicago, Chicago, IL 60637
    J Immunol 196:3191-8. 2016
    ..However, the impact of the other major pathway triggered by intracellular DNA, the absent in melanoma 2 (AIM2) inflammasome, on the functional output from the stimulator of IFN genes (STING) pathway is poorly understood...
  37. pmc Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection
    Nastaran Mohammadi
    Department of Clinical and Experimental Medicine, University of Messina, 98125, Messina, Italy
    PLoS ONE 11:e0160249. 2016
    ..These cells directly recognize GBS by means of endosomal TLRs and cytosolic sensors, leading to activation of the caspase-1 inflammasome. ..
  38. pmc AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity
    Antonia Di Micco
    Department of Biochemistry, University of Lausanne, Epalinges 1066, Switzerland
    Proc Natl Acad Sci U S A 113:E4671-80. 2016
    ..Moreover, deficiency of the cytosolic DNA-sensor AIM2 impaired Nelfinavir-mediated inflammasome activation...
  39. pmc The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
    Elizabeth E Gray
    Department of Immunology, University of Washington School of Medicine, Seattle, WA, 98195, USA
    Immunity 45:255-66. 2016
    ..Multiple DNA sensors have been proposed to activate this pathway, including AIM2-like receptors (ALRs). Whether the ALRs are essential for activation of this pathway remains unknown...
  40. pmc AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
    V Sagulenko
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Cell Death Differ 20:1149-60. 2013
    ..Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-containing-3) recruits procaspase-1 via ..
  41. pmc Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
    Jianghong Wu
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Clin Immunol 30:693-702. 2010
    ..Here, we have used macrophages from AIM2-, NLRC4-, NLRP3-, and ASC-deficient mice to demonstrate that AIM2, NLRC4, and NLRP3 inflammasomes as well as the ..
  42. doi AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation
    Weijuan Zhang
    Institute for Immunobiology and Department of Immunology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    J Clin Immunol 33:925-37. 2013
    ..However, DNA sensor(s) involved in apopDNA-induced macrophage activation and lupus nephritis remains largely undefined. Herein, we aimed to reveal the DNA sensor(s) involved in SLE disease...
  43. pmc Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation
    Tyler K Ulland
    Inflammation Program, University of Iowa, Iowa City, Iowa, USA
    Infect Immun 81:201-8. 2013
    ..Escape of F. tularensis from the phagosome into the cytosol of the macrophage triggers the activation of the AIM2 inflammasome through a mechanism that is not well understood...
  44. pmc Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation
    Qian Yin
    Program in Cellular and Molecular Medicine, Boston Children s Hospital, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 4:327-39. 2013
    ..p202 containing two hemopoietic expression, interferon inducibility, nuclear localization (HIN) domains antagonizes AIM2 inflammasome signaling and potentially modifies lupus susceptibility...
  45. pmc Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system
    Swati Shah
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
    J Immunol 191:3514-8. 2013
    ..It is puzzling that this extracellular DNA of M. tuberculosis does not induce activation of the AIM2 inflammasome because AIM2 recognizes cytosolic DNA...
  46. pmc Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    Kenichi Shimada
    Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA
    Immunity 36:401-14. 2012
    ..These results provide a missing link between apoptosis and inflammasome activation, via binding of cytosolic oxidized mtDNA to the NLRP3 inflammasome...
  47. pmc Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells
    Kamila Belhocine
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Microbiol 14:71-80. 2012
    ..escapes the initial phagosome and replicates in the cytosol, where it is detected by the cytosolic DNA sensor AIM2 leading to activation of the AIM2 inflammasome...
  48. pmc Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 188:270-8. 2012
    ..the murine lupus susceptibility locus Nba2 includes the IFN-regulated genes Ifi202 (encoding for the p202 protein), Aim2 (encoding for the Aim2 protein), and Fcgr2b (encoding for the FcγRIIB receptor), we investigated whether the IRF5/..
  49. doi Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III
    Michael Wenzel
    Department of Medicine, Ludwig Maximilian University of Munich, Munich, Germany
    J Immunol 188:394-403. 2012
    ..DNA or infection with modified vaccinia virus Ankara (MVA) can trigger cell death via the absent in melanoma 2 (AIM2) inflammasome...
  50. pmc The protein SdhA maintains the integrity of the Legionella-containing vacuole
    Elizabeth A Creasey
    Department of Molecular Biology and, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 109:3481-6. 2012
    ..This vacuolar niche affords the bacterium protection from cytosolic host factors that degrade bacteria and initiate immune responses...
  51. pmc Role of inflammasomes in host defense against Citrobacter rodentium infection
    Zhiping Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:16955-64. 2012
    ..Thus, production of IL-1β and IL-18 downstream of the Nlrp3 and Nlrc4 inflammasomes plays a critical role in host defense against enteric infections caused by C. rodentium...
  52. pmc Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking
    Jianning Ge
    National Institute of Biological Sciences, Beijing 102206, China
    Proc Natl Acad Sci U S A 109:6193-8. 2012
    ..activation phenotypes were independent of the established flagellin-NAIP5-NLRC4 axis, but relied on the DNA-sensing AIM2 inflammasome...
  53. ncbi Critical role of AIM2 in Mycobacterium tuberculosis infection
    Hiroyuki Saiga
    Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Int Immunol 24:637-44. 2012
    Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria...
  54. pmc The mammalian PYHIN gene family: phylogeny, evolution and expression
    Jasmyn A Cridland
    The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, QLD 4072, Australia
    BMC Evol Biol 12:140. 2012
    ..The family member absent in melanoma 2 (AIM2) binds cytosolic DNA via its HIN domain and initiates inflammasome formation via its pyrin domain...
  55. pmc Crystallographic characterization of mouse AIM2 HIN-200 domain bound to a 15 bp and an 18 bp double-stranded DNA
    Min Woo Sung
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1081-4. 2012
    b>AIM2 (absent in melanoma 2) is an innate immune receptor for cytosolic double-stranded DNA (dsDNA). The engagement of dsDNA by AIM2 activates the AIM2 inflammasome, resulting in the cleavage of pro-interleukin-1β by caspase-1...
  56. doi Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection
    Marco Túlio R Gomes
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270 901 Brazil
    J Immunol 190:3629-38. 2013
    ..Therefore, we decided to investigate the function of NLRC4, NLRP3, and AIM2 in sensing Brucella...
  57. pmc Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop
    C Juruj
    International Center for Infectiology Research, Université de Lyon Lyon, France
    Front Cell Infect Microbiol 3:14. 2013
    ..Recognition of DNA within the host cytosol induces the formation of a large complex composed of the AIM2 receptor, the ASC adaptor and the caspase-1 effector...
  58. pmc Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, United States
    Mol Immunol 49:273-80. 2011
    Upon sensing cytosolic double-stranded DNA (dsDNA), the murine Aim2 (encoded by the Aim2 gene) protein forms an inflammasome and promotes the secretion of proinflammatory cytokines, such as IL-1β and IL-18...
  59. pmc NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    Eran Elinav
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 145:745-57. 2011
    ..Altogether, perturbations in this inflammasome pathway, including NLRP6, ASC, caspase-1, and IL-18, may constitute a predisposing or initiating event in some cases of human IBD...
  60. pmc Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 186:6762-70. 2011
    Murine Aim2 and Ifi202 genes (encoding for the Aim2 and p202 proteins) are members of the IFN-inducible Ifi200 gene family...
  61. pmc Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 185:7385-93. 2010
    Murine Aim2 and p202 proteins (encoded by the Aim2 and Ifi202 genes) are members of the IFN-inducible p200 protein family. Both proteins can sense dsDNA in the cytoplasm...
  62. pmc Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
    Sarah Kim
    Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
    Eur J Immunol 40:1545-51. 2010
    ..Here, we demonstrate that L. monocytogenes activates both the NLRP3 and the AIM2 inflammasome, with a predominant involvement of the AIM2 inflammasome. In addition, L...
  63. doi An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
    Tilmann Burckstummer
    Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    Nat Immunol 10:266-72. 2009
    ..that associate with DNA, 'crossed' to a screen for transcripts induced by interferon-beta, which identified AIM2 as a candidate cytoplasmic DNA sensor. AIM2 showed specificity for double-stranded DNA...
  64. pmc Diversification of stem cell molecular repertoire by alternative splicing
    Moshe Pritsker
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 102:14290-5. 2005
    ..Our studies reveal extensive modification of the stem cell molecular repertoire by alternative splicing and provide insights into its overall role as a mechanism of generating genomic diversity...