Agrp

Summary

Gene Symbol: Agrp
Description: agouti related neuropeptide
Alias: Agrt, Art, agouti-related protein, orexigenic neuropeptide
Species: mouse

Top Publications

  1. pmc Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 137:1225-34. 2009
  2. ncbi Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice
    Christopher B Kaelin
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5323, USA
    Endocrinology 145:5798-806. 2004
  3. ncbi Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons
    Kanji A Takahashi
    Vollum Institute and The Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocrinology 146:1043-7. 2005
  4. ncbi Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
    Gavin A Bewick
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London, UK
    FASEB J 19:1680-2. 2005
  5. ncbi NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    Serge Luquet
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Science 310:683-5. 2005
  6. ncbi Agouti-related protein-deficient mice display an age-related lean phenotype
    Katherine E Wortley
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell Metab 2:421-7. 2005
  7. pmc AgRP-deficiency could lead to increased lifespan
    Stephen M Redmann
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 351:860-4. 2006
  8. pmc Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    Esther van de Wall
    Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 12461, USA
    Endocrinology 149:1773-85. 2008
  9. pmc Starvation after AgRP neuron ablation is independent of melanocortin signaling
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2687-92. 2008
  10. doi Activation of Stat3 signaling in AgRP neurons promotes locomotor activity
    Andrea Mesaros
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Center of Molecular Medicine Cologne, and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 7:236-48. 2008

Research Grants

Scientific Experts

  • Su Qian
  • Marcelo O Dietrich
  • Young Bum Kim
  • Chian Yu Peng
  • Maria J Barnes
  • Ida A K Nilsson
  • W Pan
  • S R Salton
  • Clemence Blouet
  • Ofer Reizes
  • Anthony P Coll
  • Kanji A Takahashi
  • X M Guan
  • K Augustine
  • Bradford B Lowell
  • Qi Wu
  • Richard D Palmiter
  • Streamson Chua
  • Gregory S Barsh
  • Michael J Krashes
  • Genevieve Marcelin
  • Chianping Ye
  • Joel K Elmquist
  • Shun Mei Liu
  • Christopher B Kaelin
  • Allison W Xu
  • Bhavik P Shah
  • Scott M Sternson
  • Zongfang Yang
  • Tiemin Liu
  • Shuichi Koda
  • Deniz Atasoy
  • Young Hwan Jo
  • Yongheng Cao
  • Louise E Olofsson
  • Denise D Belsham
  • Kristy Iskandar
  • Gary J Schwartz
  • Streamson C Chua
  • Michael A Cowley
  • Tiago Branco
  • Serge Luquet
  • George Argyropoulos
  • Alastair S Garfield
  • Verena Albert
  • Katie Sokolowski
  • Yael Mandelblat-Cerf
  • Angie C N Chong
  • Juan Salvatierra
  • Qian Wang
  • Jennifer A Chalmers
  • Bora Lee
  • James P Warne
  • Hu Huang
  • Zhonglei Lu
  • Xiaosong Li
  • Hongxia Ren
  • Davelene D Israel
  • Charlotte E Lee
  • B D Wilson
  • Jens C Bruning
  • Oksana Gavrilova
  • Aster H Juan
  • Bruno Pillot
  • Na Luo
  • Jeffrey M Zigman
  • Yexica Aponte
  • Marcus P Corander
  • Olha Ilnytska
  • Linh Vong
  • Susmita Kaushik
  • Yoshitake Hayashi
  • Csaba Fekete
  • Wataru Ogawa
  • Jun Nakae
  • Tetsuo Noda
  • Toshihiko Yada
  • Masanori Nakata
  • Eisuke Takano
  • Hiroshi Itoh
  • Masato Kasuga
  • Nae J Dun
  • Carl De Luca
  • M Navarro
  • Yasuhiko Minokoshi
  • Christopher M Mayer
  • Domenico Accili
  • Juli E Jones
  • G S Barsh
  • Colin T Phillips

Detail Information

Publications93

  1. pmc Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 137:1225-34. 2009
    Neurons in the arcuate nucleus that produce AgRP, NPY, and GABA (AgRP neurons) promote feeding. Ablation of AgRP neurons in adult mice results in Fos activation in postsynaptic neurons and starvation...
  2. ncbi Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice
    Christopher B Kaelin
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5323, USA
    Endocrinology 145:5798-806. 2004
    Agouti-related protein (Agrp) encodes a hypothalamic neuropeptide that promotes positive energy balance by stimulating food intake and reducing energy expenditure...
  3. ncbi Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons
    Kanji A Takahashi
    Vollum Institute and The Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocrinology 146:1043-7. 2005
    The neuropeptide Y (NPY)/Agouti-related protein (AgRP) neurons of the hypothalamic arcuate nucleus are thought to promote feeding...
  4. ncbi Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
    Gavin A Bewick
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London, UK
    FASEB J 19:1680-2. 2005
    Agouti-related protein (AgRP) and neuropeptide Y (NPY) are colocalized in arcuate nucleus (arcuate) neurons implicated in the regulation of energy balance...
  5. ncbi NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    Serge Luquet
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Science 310:683-5. 2005
    Hypothalamic neurons that express neuropeptide Y (NPY) and agouti-related protein (AgRP) are thought to be critical regulators of feeding behavior and body weight...
  6. ncbi Agouti-related protein-deficient mice display an age-related lean phenotype
    Katherine E Wortley
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell Metab 2:421-7. 2005
    Endogenous modulators of the central melanocortin system, such as the agouti-related protein (AgRP), should hold a pivotal position in the regulation of energy intake and expenditure...
  7. pmc AgRP-deficiency could lead to increased lifespan
    Stephen M Redmann
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 351:860-4. 2006
    The Agouti-related protein (AgRP) is a central orexigenic peptide leading to increased food intake when ubiquitously overexpressed. AgRP-deficient (AgRP(-/-)) mice have either no phenotype or present an age-related leanness...
  8. pmc Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    Esther van de Wall
    Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 12461, USA
    Endocrinology 149:1773-85. 2008
    Two known types of leptin-responsive neurons reside within the arcuate nucleus: the agouti gene-related peptide (AgRP)/neuropeptide Y (NPY) neuron and the proopiomelanocortin (POMC) neuron...
  9. pmc Starvation after AgRP neuron ablation is independent of melanocortin signaling
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2687-92. 2008
    Ablation of inhibitory agouti-related protein (AgRP)-expressing neurons in the arcuate nucleus that also synthesize gamma-amino-butyric acid (GABA) and neuropeptide Y in adult mice leads to starvation within 1 week...
  10. doi Activation of Stat3 signaling in AgRP neurons promotes locomotor activity
    Andrea Mesaros
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Center of Molecular Medicine Cologne, and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 7:236-48. 2008
    ..One of the leptin-regulated neuronal subtypes in the ARC are agouti-related peptide (AgRP)-expressing neurons, which are involved in the regulation of food intake and are directly inhibited by leptin...
  11. pmc The role of the Agouti-Related Protein in energy balance regulation
    O Ilnytska
    Pennington Biomedical Research Center, LSU System, Baton Rouge, Louisiana 70809, USA
    Cell Mol Life Sci 65:2721-31. 2008
    The Agouti-Related Protein (AgRP) is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally...
  12. pmc Monitoring FoxO1 localization in chemically identified neurons
    Makoto Fukuda
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Neurosci 28:13640-8. 2008
    ..Using this model, we found that insulin treatment resulted in the nuclear exclusion of FoxO1GFP within POMC and AgRP neurons in a dose- and time-dependent manner...
  13. pmc Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, Boston, Massachusetts 02215, USA
    Nat Neurosci 11:998-1000. 2008
    ..To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of ..
  14. ncbi Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    M M Ollmann
    Department of Pediatrics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 278:135-8. 1997
    ..Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation...
  15. pmc Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice
    M Navarro
    Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    Genes Brain Behav 8:450-8. 2009
    ..Agouti-related protein (AgRP) is synthesized by neurons in the arcuate nucleus of the hypothalamus and is a natural antagonist of MCRs...
  16. pmc Preference for a high fat diet, but not hyperphagia following activation of mu opioid receptors is blocked in AgRP knockout mice
    Maria J Barnes
    Pennington Biomedical Research Center, Nutrition and Neural Signaling Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 1317:100-7. 2010
    ..The orexigenic peptide Agouti Related Peptide (AgRP) also produces hyperphagia and increased the preference for a high fat diet...
  17. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..These data suggest a requirement for PDK-1 and FoxO1 in transcriptional regulation of Pomc and food intake...
  18. pmc AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
    Yexica Aponte
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Neurosci 14:351-5. 2011
    Two intermingled hypothalamic neuron populations specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC) positively and negatively influence feeding behavior, respectively, possibly by reciprocally ..
  19. pmc Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
    Michael J Krashes
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 121:1424-8. 2011
    ..Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete...
  20. pmc Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    Linh Vong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, EC CLS717, Boston, MA 02215, USA
    Neuron 71:142-54. 2011
    ..Leptin, working directly on presynaptic GABAergic neurons, many of which appear not to express AgRP, reduces inhibitory tone to postsynaptic POMC neurons...
  21. pmc Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone
    Tiemin Liu
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Neuron 73:511-22. 2012
    b>AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input in controlling these neurons is unknown...
  22. pmc Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice
    Genevieve Marcelin
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Lipid Res 53:964-72. 2012
    ..Marcelin, G., S-M. Liu, X. Li, G. J. Schwartz, and S. Chua...
  23. pmc Deciphering a neuronal circuit that mediates appetite
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 483:594-7. 2012
    Hypothalamic neurons that co-express agouti-related protein (AgRP), neuropeptide Y and γ-aminobutyric acid (GABA) are known to promote feeding and weight gain by integration of various nutritional, hormonal, and neuronal signals...
  24. pmc Deconstruction of a neural circuit for hunger
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive Ashburn, Virginia 20147, USA
    Nature 488:172-7. 2012
    ..These behaviours are rapidly recapitulated by activation of starvation-sensitive AGRP neurons, which present an entry point for reverse-engineering neural circuits for hunger...
  25. pmc Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP
    Michael J Krashes
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 18:588-95. 2013
    Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions...
  26. ncbi Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
    J R Shutter
    Amgen Inc, Amgen Center, Thousand Oaks, California 91320, USA
    Genes Dev 11:593-602. 1997
    We have isolated cDNA clones that encode a novel human gene related to agouti. Sequence analysis of this gene, named ART, for agouti-related transcript, predicts a 132-amino-acid protein that is 25% identical to human agouti...
  27. ncbi Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    T M Hahn
    Nat Neurosci 1:271-2. 1998
  28. pmc The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    C Broberger
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 95:15043-8. 1998
    Neuropeptide Y (NPY) and the endogenous melanocortin receptor antagonist, agouti gene-related protein (AGRP), coexist in the arcuate nucleus, and both exert orexigenic effects...
  29. ncbi Overexpression of Agrt leads to obesity in transgenic mice
    M Graham
    Nat Genet 17:273-4. 1997
  30. ncbi Physiological and anatomical circuitry between Agouti-related protein and leptin signaling
    B D Wilson
    Department of Pediatrics, and Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5428, USA
    Endocrinology 140:2387-97. 1999
    Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice...
  31. pmc Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice
    Su Qian
    Department of Obesity and Metabolic Research, Merck Research Laboratories, Rahway, NJ 07065, USA
    Mol Cell Biol 22:5027-35. 2002
    Agouti-related protein (AgRP), a neuropeptide abundantly expressed in the arcuate nucleus of the hypothalamus, potently stimulates feeding and body weight gain in rodents...
  32. ncbi Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse
    Csaba Fekete
    Ph D, Professor of Medicine, Division of Endocrinology, Box No 268, Tufts New England Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USA
    Endocrinology 145:4816-21. 2004
    Agouti-related protein (AGRP) is thought to be one of the neuropeptides mediating the effects of leptin on appetite and satiety...
  33. ncbi Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway
    Ofer Reizes
    Procter Gamble Pharmaceuticals, Inc, Health Care Research Center, Mason, Ohio 45040, USA
    Ann N Y Acad Sci 994:66-73. 2003
    ..hypothesis that syndecan-3 modulates melanocortin activity via syndecan-3 facilitation of agouti-related protein (AgRP), a competitive antagonist of alpha-melanocyte-stimulating hormone (alpha-MSH) at the melanocortin-3 and -4 ..
  34. ncbi Central and peripheral interactions between the agouti-related protein and leptin
    Chantal Charbonneau
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 319:518-24. 2004
    The agouti-related protein (AgRP) is a powerful appetite modulator expressed in the hypothalamus and the adrenal gland and regulated by leptin...
  35. ncbi Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    H Y Chen
    Department of Metabolic Disorders, Merck Research Laboratories, P O Box 2000, RY80T 150, Rahway, New Jersey 07065, USA
    Endocrinology 145:2607-12. 2004
    ..indicates that ghrelin's effects on food intake are mediated by neuropeptide Y (NPY) and agouti-related protein (AgRP) in the central nervous system...
  36. ncbi Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
    Hongqin Wang
    Metabolic Research Center, Department of Biomedical Science, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Am J Physiol Endocrinol Metab 282:E1352-9. 2002
    ..leptin, and leptin-related neural peptides: leptin receptor, neuropeptide Y (NPY), agouti-related peptide (AgRP), and proopiomelanocortin (POMC), in C57Bl/6J mice...
  37. ncbi Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    Tadahiro Kitamura
    Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, New York 10032, USA
    Nat Med 12:534-40. 2006
    ..nucleus of rodents results in a loss of the ability of leptin to curtail food intake and suppress expression of Agrp. Conversely, a transactivation-deficient FoxO1 mutant prevents induction of Agrp by fasting...
  38. pmc Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice
    Bruno Pillot
    Institut National de la Sante et de la Recherche Medicale, U855, Lyon, France
    PLoS ONE 6:e19107. 2011
    ..and its ligands: α-melanin-stimulating hormone (α-MSH, agonist, inducing hypophagia), and agouti-related protein (AgRP, antagonist, inducing hyperphagia)--is considered to play a central role in the control of food intake...
  39. pmc Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight
    Tiago Branco
    Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA Division of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK Electronic address
    Cell 165:1749-61. 2016
    ..7 (Scn9a), previously associated with pain-sensation but not synaptic integration. Scn9a deletion in AGRP, POMC, or paraventricular hypothalamic neurons reduced EPSP duration, synaptic integration, and altered body weight ..
  40. doi mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior
    Verena Albert
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Biochem Biophys Res Commun 464:480-6. 2015
    Orexigenic agouti-related protein/neuropeptide Y (Agrp/NPY) neurons and an orexigenic pro-opiomelanocortin (POMC) neurons of the hypothalamus regulate feeding behavior and energy homeostasis...
  41. pmc FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
    Hongxia Ren
    Berrie Diabetes Center, Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell 149:1314-26. 2012
    Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this response remain elusive...
  42. pmc Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales
    Yael Mandelblat-Cerf
    Department of Endocrinology, Beth Israel Deaconess Medical Center, Boston, United States
    elife 4:. 2015
    Agouti-related-peptide (AgRP) neurons-interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)-are both necessary and sufficient for driving feeding behavior...
  43. pmc BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior
    Chian Yu Peng
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 32:17211-24. 2012
    ..Although the hypophagia promoted expression of the orexigenic neuropeptide agouti related protein (AgRP) in the BMPR1A-deficient ARH, there was a profound decrease of AgRP(+) ..
  44. pmc A neural basis for melanocortin-4 receptor-regulated appetite
    Alastair S Garfield
    1 Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA 2 Centre for Integrative Physiology, Hugh Robson Building, University of Edinburgh, Edinburgh, UK
    Nat Neurosci 18:863-71. 2015
    Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by caloric depletion and coordinately stimulate and inhibit homeostatic satiety, ..
  45. pmc Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein
    James P Warne
    Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 33:11972-85. 2013
    ..Removal of leptin receptors from AGRP neurons diminishes fasting-induced hepatic steatosis...
  46. pmc ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice
    Hu Huang
    PhD, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215
    Endocrinology 154:3660-70. 2013
    ..Proopiomelanocortin- and agouti-related peptide (AgRP)-producing neurons play critical roles in regulating energy metabolism...
  47. pmc Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035, Brazil Electronic address
    Cell 155:188-99. 2013
    ..Here, we show that mitochondria number decrease but their size increase in orexigenic agouti-related protein (Agrp) neurons during the transition from fasted to fed to overfed state...
  48. doi Glucose sensing mechanisms in hypothalamic cell models: glucose inhibition of AgRP synthesis and secretion
    Jennifer A Chalmers
    Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Cell Endocrinol 382:262-70. 2014
    ..As models of glucose-inhibited (GI) neurons, mHypoE-29/1 and mHypoA-NPY/GFP cells express the essential orexigenic neuropeptide AgRP and glucose sensing machinery...
  49. pmc Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin
    Qian Wang
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Metab 3:64-72. 2014
    ..While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance of ghrelin signaling within intact AgRP neurons is unclear...
  50. pmc Specification of select hypothalamic circuits and innate behaviors by the embryonic patterning gene dbx1
    Katie Sokolowski
    Center for Neuroscience Research, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Neuron 86:403-16. 2015
    ..Thus, activity of a single developmentally regulated gene, Dbx1, is a shared requirement for the specification of hypothalamic nuclei governing a subset of innate behaviors. VIDEO ABSTRACT. ..
  51. pmc The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation
    Juan Salvatierra
    Department of Neuroscience
    J Neurosci 34:16809-20. 2014
    ..These findings provide key insights into the transcriptional regulatory network specifying this still poorly characterized cell type...
  52. pmc Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness
    Angie C N Chong
    Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA
    Mol Metab 4:83-92. 2015
    ..Here we examined whether disrupting signaling via the insulin receptor (InsR) in hypothalamic subpopulations impacts the neuroendocrine response to acute psychological stress...
  53. pmc pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location
    Zhonglei Lu
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    EMBO J 32:844-57. 2013
    ..The Arcuate nucleus (ARC) in hypothalamus contains antagonizing POMC and AGRP/NPY neurons for negative and positive energy balance, respectively...
  54. pmc Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:3155-60. 2012
    ..Ablation of neurons that make agouti-related protein (AgRP) in moderately obese adult Lep(ob/ob) mice caused severe anorexia...
  55. pmc Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction
    Davelene D Israel
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 153:2408-19. 2012
    ..These studies thus establish melanocortin signaling as an important component in the leptin-mediated regulation of GnRH neuron activity, initiation of puberty and fertility...
  56. pmc TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity
    Clemence Blouet
    Departments of Medicine and Neuroscience of The Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 32:9870-7. 2012
    ..To evaluate the metabolic role of TXNIP activity specifically within arcuate Agrp neurons, we generated Agrp-specific TXNIP gain-of-function and loss-of-function mouse models using Agrp-Ires-cre ..
  57. pmc Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance
    Bora Lee
    Neuroscience Section, Papé Family Pediatric Research Institute, Department of Pediatrics
    Mol Cell Biol 33:2650-8. 2013
    ..Brain-specific homeobox factor (Bsx) is a positive regulator of the orexigenic neuropeptide, agouti-related peptide (AgRP), in AgRP neurons of the hypothalamic arcuate nucleus...
  58. ncbi Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
    T M Mizuno
    Fishberg Center for Neurobiology, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 140:814-7. 1999
    Agouti-related protein (AGRP) is a homologue of the agouti gene product and, when overexpressed, promotes obesity...
  59. pmc Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
    Susmita Kaushik
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Metab 14:173-83. 2011
    ..Here we demonstrate a role for autophagy in hypothalamic agouti-related peptide (AgRP) neurons in the regulation of food intake and energy balance...
  60. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
    ..However, little is known about whether PDK1 in agouti-related peptide (AGRP) neurons contributes to energy homeostasis...
  61. pmc Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite
    Olha Ilnytska
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, USA
    Diabetes 60:97-106. 2011
    The agouti-related protein (Agrp) is a powerful orexigenic peptide, but little is known about its transcriptional regulation...
  62. pmc Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells
    Aster H Juan
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal, and Skin Diseases NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 25:789-94. 2011
    ..These defects are associated with impaired SC proliferation and derepression of genes expressed in nonmuscle cell lineages. Thus, EZH2 controls self-renewal and proliferation, and maintains an appropriate transcriptional program in SCs...
  63. ncbi Rodent mutant models of obesity and their correlations to human obesity
    K A Augustine
    SmithKline Beecham Pharmaceuticals, Department of Reproductive Toxicology, King of Prussia, PA 19406, USA
    Anat Rec 257:64-72. 1999
    ..In this review, we discuss the physiology and genetics underlying obesity and how studies in rodents and humans are converging, producing a greater understanding of the mechanisms underlying this health problem...
  64. ncbi Anorexigenic melanocortin signaling in the hypothalamus is augmented in association with failure-to-thrive in a transgenic mouse model for Prader-Willi syndrome
    Yin lin Ge
    University of Florida McKnight Brain Institute, College of Medicine, Department of Neuroscience, PO Box 100244, Gainesville, FL 32610, USA
    Brain Res 957:42-5. 2002
    ..In rodents, the hypothalamic neuropeptide, Neuropeptide Y (NPY) and Agouti-related peptide (AgrP) stimulate while alpha-melanocyte stimulating hormone (alpha-MSH) inhibits appetite...
  65. ncbi Ectopic Agouti protein overexpression increases stimulated corticosterone production without effect on adenylate cyclase activity in mouse adrenal cells
    Antonyna Y Shevchenko
    Institute of Cytology and Genetics of the Russian Academy of Sciences, Pr Lavrentjeva 10, Novosibirsk 630090, Russia
    Eur J Endocrinol 151:613-8. 2004
    ..The aim of the present study was to estimate the effect of ectopic AP overexpression on the activity of AC and steroidogenic intracellular enzymes...
  66. ncbi Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice
    M Bäckberg
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Brain Res Mol Brain Res 125:129-39. 2004
    ..we have investigated whether obese tub/tub mice exhibit altered expression levels for agouti-related protein (AGRP) or glutamic acid decarboxylase-65 (GAD65) in body weight-regulating neurons of the hypothalamic arcuate nucleus...
  67. ncbi Expression of agouti-related peptide, neuropeptide Y, pro-opiomelanocortin and the leptin receptor isoforms in fetal mouse brain from pregnant dams on a protein-restricted diet
    Paul L Terroni
    Centre for Developmental Origins of Health and Disease, University of Southampton, School of Medicine, Princess Anne Hospital, Level F mailpoint 887, Coxford Road, Southampton, UK
    Brain Res Mol Brain Res 140:111-5. 2005
    ..Levels of expression for these genes were altered in brains of E12 fetuses from pregnant dams on a protein-restricted diet, suggesting that the fetal brain is responsive to changes in maternal nutrition prior to birth...
  68. ncbi Selective tissue uptake of agouti-related protein(82-131) and its modulation by fasting
    Weihong Pan
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 70808, USA
    Endocrinology 146:5533-9. 2005
    The blood concentration of agouti-related protein (AgRP), a protein related to hyperphagia and obesity, is increased in obese human and fasted lean subjects...
  69. ncbi Origin of neuropeptide Y-containing afferents to gonadotropin-releasing hormone neurons in male mice
    Gergely F Turi
    Department of Endocrine and Behavioral Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    Endocrinology 144:4967-74. 2003
    ..1 +/- 7.3% of NPY axons apposed to green GnRH neurons also contained agouti-related protein (AGRP), a selective marker for NPY axons arising from the ARC...
  70. ncbi Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid
    Christopher B Kaelin
    Department of Genetics and Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Endocrinol 20:2591-602. 2006
    ..of transcription 3 (Stat3) in hypothalamic neurons, including neuronal subtypes producing Agouti-related protein (Agrp), a neuropeptide that stimulates feeding...
  71. ncbi Overexpression of glucose transporter 2 in GT1-7 cells inhibits AMP-activated protein kinase and agouti-related peptide expression
    Bing Li
    School of Human Ecology, Louisiana State University AgCenter and Pennington Biomedical Research Center, Baton Rouge, LA 70803, USA
    Brain Res 1118:1-5. 2006
    ..increased cellular ATP levels at 5 and 25 mM glucose concentrations, more inhibition of agouti-related peptide (AgRP) mRNA and AMP-activated protein kinase (AMPK) phosphorylation by glucose, and attenuated stimulation of AgRP mRNA ..
  72. ncbi Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
    Heike Munzberg
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:69-74. 2007
    ....
  73. pmc Dmbx1 is essential in agouti-related protein action
    Wakako Fujimoto
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Proc Natl Acad Sci U S A 104:15514-9. 2007
    ..Thus, Dmbx1 is essential for various actions of agouti-related protein and plays a role in normal regulation of energy homeostasis and behavior...
  74. ncbi Role of agouti-related protein-expressing neurons in lactation
    Colin T Phillips
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Endocrinology 149:544-50. 2008
    Hypothalamic neurons that express agouti-related protein (AgRP) and neuropeptide Y (NPY) are thought to be important for regulation of feeding, especially under conditions of negative energy balance...
  75. ncbi Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation
    Hui Cheng
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Endocrinology 149:703-10. 2008
    ..To address these molecular mechanisms further, we have examined the regulation of agouti-related peptide (AgRP) in a clonal hypothalamic cell line, N-38...
  76. ncbi Aberrant agouti-related protein system in the hypothalamus of the anx/anx mouse is associated with activation of microglia
    Ida Nilsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    J Comp Neurol 507:1128-40. 2008
    Agouti-related protein (AgRP) is a key orexigenic neuropeptide expressed in the hypothalamic arcuate nucleus and a marker for neurons conveying hormonal signals of hunger to the brain...
  77. ncbi The d subunit of the vacuolar ATPase (Atp6d) is essential for embryonic development
    Grant I Miura
    Transgenic Res 12:131-3. 2003
  78. pmc A model for obesity and gigantism due to disruption of the Ankrd26 gene
    Tapan K Bera
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Proc Natl Acad Sci U S A 105:270-5. 2008
    ..These results show that alterations in an unidentified gene can lead to obesity and identify a molecular target for the treatment of obesity...
  79. pmc Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency
    Marcus P Corander
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Addenbrooke s Hospital, Cambridge, UK
    Endocrinology 152:1819-28. 2011
    ..homeostasis, in that both anorexigenic proopiomelanocortin (POMC)-derived and orexigenic Agouti related-peptide (AgRP)-derived ligands act at the same receptors, namely melanocortin 3 and 4 receptors (MC3/4R)...
  80. pmc Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation
    Jarrad M Scarlett
    Center for the Study of Weight Regulation and Associated Disorders, Department of Pediatrics, Oregon Health and Science University Child Development and Rehabiliation Center Portland, Portland, OR 97239, USA
    Endocrinology 149:4837-45. 2008
    Agouti-related protein (AgRP) is an orexigenic neuropeptide produced by neurons in the hypothalamic arcuate nucleus (ARC) that is a key component of central neural circuits that control food intake and energy expenditure...
  81. pmc Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions
    Qi Wu
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:9218-26. 2008
    ..The model involves targeting the human DT receptor to the agouti-related protein (Agrp) locus so that systemic administration of DT kills all of the AgRP-expressing neurons, resulting in starvation of ..
  82. ncbi Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse
    K Arvaniti
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique, Universite Laval, Quebec, Canada
    Neuroendocrinology 73:227-36. 2001
    ..on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain...
  83. doi Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons
    Christopher M Mayer
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Mol Cell Endocrinol 307:99-108. 2009
    ..Neuropeptide Y (NPY) and agouti-related peptide (AgRP) are vital orexigenic peptides that are regulated by insulin, although the processes utilized are unknown...
  84. ncbi Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice
    H Makimura
    Fishberg Center for Neurobiology, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes 49:1917-23. 2000
    ..exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalamic agouti-related peptide (AGRP) mRNA and neuropeptide Y (NPY) mRNA...
  85. pmc Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake
    Louise E Olofsson
    Diabetes Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:15932-7. 2009
    ..In this study, we show that changes in hypothalamic expression of agouti-related protein (Agrp) and neuropeptide Y (Npy) coincide with the cyclic changes in feeding across the estrous cycle...
  86. ncbi Of mice and MEN: what transgenic models tell us about hypothalamic control of energy balance
    S R Salton
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neuron 25:265-8. 2000
  87. doi Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity
    Xiao Ming Guan
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Cell Metab 11:101-12. 2010
    ..BRS-3 agonist effectiveness was absent in Brs3(-/Y) (BRS-3 null) mice but was maintained in Npy(-/-)Agrp(-/-), Mc4r(-/-), Cnr1(-/-), and Lepr(db/db) mice...
  88. ncbi Agouti and agouti-related protein: analogies and contrasts
    D M Dinulescu
    Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 275:6695-8. 2000
  89. ncbi The role of agouti-related protein in regulating body weight
    B D Wilson
    Stanford University School of Medicine, B275 Beckman Center, Stanford, CA 94305 5428, USA
    Mol Med Today 5:250-6. 1999
    ..Recently, two potential downstream mediators, agouti-related protein (Agrp) and its receptor, the melanocortin-4 receptor (Mc4r), have been identified...
  90. pmc Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency
    Na Luo
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 12401, USA
    Endocrinology 152:883-9. 2011
    Neuropeptide Y (NPY) and agouti-related peptide (AGRP) can produce hyperphagia, reduce energy expenditure, and promote triglyceride deposition in adipose depots...
  91. ncbi A biochemical function for attractin in agouti-induced pigmentation and obesity
    L He
    Departments of Pediatric, Stanford University School of Medicine, Stanford, California, USA
    Nat Genet 27:40-7. 2001
    ..is ectopically expressed in lethal yellow (A(y)) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the hypothalamus...
  92. ncbi Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken
    S Takeuchi
    Department of Biology, Faculty of Science, Okayama University, 3 1 1, Tsushimanaka, Okayama, Japan
    Biochim Biophys Acta 1496:261-9. 2000
    Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action...

Research Grants3

  1. In vivo role of Rho-kinase in glucose metabolism
    Young Bum Kim; Fiscal Year: 2007
    ..These experiments could lead to the identification of a potential target for new diabetes drugs. [unreadable] [unreadable] [unreadable]..
  2. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  3. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..