Adrb1

Summary

Gene Symbol: Adrb1
Description: adrenergic receptor, beta 1
Alias: Adrb-1, beta-AR, beta-1 adrenergic receptor, beta 1-AR, beta-1 adrenoceptor, beta-1 adrenoreceptor, cardiac beta adrenergic receptor
Species: mouse

Top Publications

  1. ncbi Physiological consequences of beta-adrenergic receptor disruption
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
    J Mol Med (Berl) 76:764-72. 1998
  2. ncbi Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 94:1091-100. 2004
  3. pmc Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction
    Dagoberto Soto
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
    Circ Res 104:770-9. 2009
  4. pmc Confinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae
    Cathleen D Valentine
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 22:2970-82. 2011
  5. pmc Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects
    D K Rohrer
    Department of Pediatrics, Stanford University, CA 94305, USA
    Proc Natl Acad Sci U S A 93:7375-80. 1996
  6. ncbi Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, California 94304, USA
    J Biol Chem 274:16701-8. 1999
  7. pmc Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
    S Engelhardt
    Institut fur Pharmakologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 96:7059-64. 1999
  8. ncbi Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice
    E Devic
    Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA
    Mol Pharmacol 60:577-83. 2001
  9. ncbi Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors
    A Chruscinski
    Howard Hughes Medical Institute, Stanford University, Stanford, California, USA
    Mol Pharmacol 60:955-62. 2001
  10. ncbi The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes
    Yang Xiang
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institution, B157 Beckman Center, Stanford Medical Center, Palo Alto, CA 94043, USA
    J Biol Chem 277:33783-90. 2002

Research Grants

Scientific Experts

  • Lorenz Lehr
  • Karin P Hammer
  • Florian Stöckigt
  • Daniel M Bernstein
  • Mary Bouxsein
  • IRA JAY GOLDBERG
  • C J Daly
  • Shinji Miura
  • Geneviève Tavernier
  • Marika Charalambous
  • Lesley A Schimanski
  • Philip W Raake
  • Ruben Nogueiras
  • B Roozendaal
  • Maria Jimenez
  • Youde Jiang
  • Soo Mi Kim
  • Walter J Koch
  • Ming Ouyang
  • Steven A Thomas
  • Jurgen Schnermann
  • Jena J Steinle
  • Muniswamy Madesh
  • Xander H T Wehrens
  • Keith Schutsky
  • D K Rohrer
  • Stephen B Liggett
  • Yang Xiang
  • Mingming Zhao
  • Limeng Chen
  • Joan Heller Brown
  • Wei Zhong Zhu
  • Yuning Huang
  • Diane Mizel
  • Josephine P Briggs
  • Brian K Kobilka
  • Giovanni Fajardo
  • Ilana Gabanyi
  • Arthur M Feldman
  • Xiangsheng Yang
  • Nicholas E Hoffman
  • Erhe Gao
  • Eline A E van der Hagen
  • Naama Volk
  • Qiuhua Zhang
  • Z Maggie Huang
  • Laetitia Pereira
  • Eva A Rog-Zielinska
  • Teppei Fujikawa
  • Xin Li
  • Yasuhiro Takayanagi
  • Timothy S Kern
  • Jan Benes
  • Cintia B Ueta
  • Oliver Vranjkovic
  • Cathleen D Valentine
  • Weizhi Zhang
  • Bruna Romana-Souza
  • Björn Neubauer
  • Stephanie L Catus
  • C F Murchison
  • Thomas Pulinilkunnil
  • Qi Chen
  • Shubai Liu
  • Emilio P Mottillo
  • Surekha Rani Panjala
  • Konstantinos Drosatos
  • Jin Zhang
  • S Lee
  • Wei Wang
  • Santhosh K Mani
  • Dong Kong
  • Jill Walker-Brown
  • Yuejin Wu
  • Dagoberto Soto
  • Mark D Levin
  • Geertje Lewin
  • ByungSu Yoo
  • Mona Oppermann
  • B K Kobilka
  • Vania De Arcangelis
  • Yongyu Wang
  • Natalia Petrashevskaya
  • A Galindo-Tovar
  • S J Swoap
  • Carley A E Shaut
  • Wito Richter
  • H Kiriazis
  • Kevin J Sampson
  • Mario Patrizio

Detail Information

Publications112 found, 100 shown here

  1. ncbi Physiological consequences of beta-adrenergic receptor disruption
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
    J Mol Med (Berl) 76:764-72. 1998
    ....
  2. ncbi Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 94:1091-100. 2004
    ..These findings indicate that betaAR signaling may not be necessary for basal AFC, and that beta2AR is essential for the adaptive physiological response needed to clear excess fluid from the alveolar airspace of normal and injured lungs...
  3. pmc Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction
    Dagoberto Soto
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
    Circ Res 104:770-9. 2009
    ..Together, our data have revealed insights into kinetics of PKA activities in signaling propagation under neurohormonal stimulation...
  4. pmc Confinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae
    Cathleen D Valentine
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 22:2970-82. 2011
    ....
  5. pmc Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects
    D K Rohrer
    Department of Pediatrics, Stanford University, CA 94305, USA
    Proc Natl Acad Sci U S A 93:7375-80. 1996
    ..These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes...
  6. ncbi Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors
    D K Rohrer
    Department of Molecular Pharmacology, Roche Bioscience, Palo Alto, California 94304, USA
    J Biol Chem 274:16701-8. 1999
    ....
  7. pmc Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
    S Engelhardt
    Institut fur Pharmakologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 96:7059-64. 1999
    ..We conclude that overexpression of beta1-adrenergic receptors in the heart may lead to a short-lived improvement of cardiac function, but that increased beta1-adrenergic receptor signalling is ultimately detrimental...
  8. ncbi Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice
    E Devic
    Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California 94305, USA
    Mol Pharmacol 60:577-83. 2001
    The sympathetic nervous system modulates cardiac contractility and rate by activating beta-adrenergic receptors (beta AR) expressed on cardiac myocytes and specialized cells in the sinoatrial node and the conduction system...
  9. ncbi Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors
    A Chruscinski
    Howard Hughes Medical Institute, Stanford University, Stanford, California, USA
    Mol Pharmacol 60:955-62. 2001
    ....
  10. ncbi The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes
    Yang Xiang
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institution, B157 Beckman Center, Stanford Medical Center, Palo Alto, CA 94043, USA
    J Biol Chem 277:33783-90. 2002
    ..These studies suggest that association of the beta(1)AR with PSD-95 or a related protein dictates signaling specificity by retaining the receptor at the cell surface and preventing interaction with G(i)...
  11. ncbi Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
    Maria Jimenez
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    FEBS Lett 530:37-40. 2002
    ..Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting...
  12. pmc Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II
    Wei Zhong Zhu
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Clin Invest 111:617-25. 2003
    ..These findings indicate that CaMKII constitutes a novel PKA-independent linkage of beta(1)AR stimulation to cardiomyocyte apoptosis that has been implicated in the overall process of chronic heart failure...
  13. ncbi Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes
    Daniel Bernstein
    Dept of Pediatrics, 750 Welch Rd, Suite 305, Palo Alto, CA 94304, USA
    Am J Physiol Heart Circ Physiol 289:H2441-9. 2005
    ....
  14. ncbi Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability
    Phillip M Ecker
    Dept of Pediatrics, Stanford University, Stanford, California, USA
    Am J Physiol Heart Circ Physiol 290:H192-9. 2006
    ..These results demonstrate the differential role of beta-AR subtypes in regulating autonomic signaling...
  15. pmc Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis
    H Kiriazis
    Department of Experimental Cardiology, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Br J Pharmacol 153:684-92. 2008
    ..We investigated the effect of beta-adrenoceptors on cardiac hypertrophic growth using beta(1)- and beta(2)-adrenoreceptor knockout and wild-type (WT) mice...
  16. ncbi Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy
    S Lee
    Department III of Internal Medicine, University of Cologne, Cologne, Germany
    Physiol Res 59:679-89. 2010
    ..The decreased SERCA 2a activity following beta-adrenoceptor deficiency may be partly compensated by an increased myofibrillar calcium-sensitivity...
  17. pmc Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β₁-adrenergic receptor knockout mouse
    Surekha Rani Panjala
    Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 17:1822-8. 2011
    ..To investigate the role of β1-adrenergic receptors on insulin like growth factor (IGF)-1 receptor signaling and apoptosis in the retina using β1-adrenergic receptor knockout (KO) mice...
  18. pmc β2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype
    Youde Jiang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 8:e70555. 2013
    ..Since the effects occurred in vivo under normal glucose conditions, we postulate that aspects of the diabetic retinopathy phenotype might be triggered by loss of β2-adrenergic receptor signaling. ..
  19. pmc Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci
    M L Watson
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    J Exp Med 176:1645-56. 1992
    ..Moreover, this study provides a model for dissecting the complex genetic interactions that result in manifestations of autoimmune disease...
  20. ncbi Isolation and molecular characterization of the B cells producing the paraprotein in a case of benign monoclonal gammapathy in C57BL mice
    N A Bos
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    Eur J Immunol 21:1893-8. 1991
    ....
  21. pmc Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function
    M Jaber
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 93:12974-9. 1996
    ....
  22. pmc Ghrelin action in the brain controls adipocyte metabolism
    Claudia Theander-Carrillo
    Laboratory of Metabolism, Division of Endocrinology, Diabetology, and Nutrition, Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Clin Invest 116:1983-93. 2006
    ..These results unravel the existence of what we believe to be a new CNS-based neuroendocrine circuit regulating metabolic homeostasis of adipose tissue...
  23. ncbi The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture
    Lorenz Lehr
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, Geneva, Switzerland
    FEBS Lett 580:4661-6. 2006
    ..Altogether the data show a dissociation between the control of UCP1, which is mostly beta-adrenoceptor-dependent and that of PGC-1alpha and of mitochondriogenesis which are not...
  24. ncbi Impaired hippocampal LTP in inbred mouse strains can be rescued by beta-adrenergic receptor activation
    Lesley A Schimanski
    Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Eur J Neurosci 25:1589-98. 2007
    ....
  25. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  26. pmc Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an I Ks transgenic mouse
    Kevin J Sampson
    Department of Pharmacology, Columbia University Medical Center, 630 W 168th St, New York, NY 10032, USA
    J Physiol 586:627-37. 2008
    ....
  27. pmc Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors
    A Galindo-Tovar
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Br J Pharmacol 153:710-20. 2008
    ..We investigated the influence of the PDE3 inhibitor cilostamide and PDE4 inhibitor rolipram on the effects of (-)-adrenaline in three regions of murine heart...
  28. pmc Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent
    Limeng Chen
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 31, Room 2B11, Bethesda, MD 20892, USA
    J Am Soc Nephrol 21:986-92. 2010
    ....
  29. doi Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy
    Natalia Petrashevskaya
    Cardiopulmonary Genomics Program, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Transl Sci 1:221-7. 2008
    ..Taken together, the unique signaling effects of enhanced beta(2)AR and AC5, which have the potential to afford benefit in heart failure, failed to salvage ventricular function in beta(1)AR-mediated cardiomyopathy...
  30. pmc Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation
    Konstantinos Drosatos
    Dept of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 300:E489-99. 2011
    ..Thus, several lipids that are increased in the setting of lipotoxicity can produce abnormalities in β-AR responsiveness. This can be attributed to PKC activation and reduced β-AR levels...
  31. doi Stress-induced epinephrine levels compromise murine dermal fibroblast activity through β-adrenoceptors
    Bruna Romana-Souza
    Department of Histology and Embryology, Rio de Janeiro State University, Rio de Janeiro, Brazil
    Exp Dermatol 20:413-9. 2011
    ..In conclusion, high levels of epinephrine directly compromise the activity of neonatal mouse skin fibroblasts through the activation of β1-, β2- and β3-adrenoceptors, but not through α1- and α2-adrenoceptors...
  32. doi Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β₁ adrenoceptor
    Yasuhiro Takayanagi
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    J Neuroimmunol 245:66-74. 2012
    ..In IELs, β₁ AR agonist xamoterol mimicked the suppressive effects of NE. These results indicated NE regulates intestinal mucosal immune responses mediated by IELs via β₁ AR...
  33. pmc β(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice
    Cintia B Ueta
    Centro de Ciencias Biologicas e da Saude, Universidade Presbiteriana Mackenzie, Rua da Consolação, 869 Prédio 16, 1 andar, 01302 907 São Paulo, Brazil
    J Endocrinol 214:359-65. 2012
    ..In conclusion, the β(1) signaling pathway mediates most of the SNS stimulation of adaptive thermogenesis...
  34. pmc Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia
    Laetitia Pereira
    Department of Pharmacology, University of California Davis, Davis, CA 95616 8636, USA
    Circulation 127:913-22. 2013
    ..In heart, selective Epac activation can induce potentially arrhythmogenic sarcoplasmic reticulum (SR) Ca(2+) release that involves Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) effects on the ryanodine receptor (RyR)...
  35. doi Glucocorticoid receptor is required for foetal heart maturation
    Eva A Rog-Zielinska
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Hum Mol Genet 22:3269-82. 2013
    ....
  36. pmc Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
    Teppei Fujikawa
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 18:431-44. 2013
    ..Collectively, our data elucidate a hypothalamic-dependent pathway enabling life without insulin and hence pave the way for developing better treatments for diseases of insulin deficiency. ..
  37. pmc Role of AKAP79/150 protein in β1-adrenergic receptor trafficking and signaling in mammalian cells
    Xin Li
    From the Department of Pharmacology, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163
    J Biol Chem 288:33797-812. 2013
    ..These results indicate a significant role for the AKAP5 scaffold in signaling and trafficking of the β1-AR in cardiac myocytes and mammalian cells. ..
  38. pmc Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury
    Z Maggie Huang
    1Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Sci Signal 6:ra95. 2013
    ..Our findings suggest new insights into the mechanism of action of classic drugs used to treat heart failure and new therapeutic approaches to ischemic heart disease. ..
  39. pmc β1-Adrenergic receptor signaling activates the epithelial calcium channel, transient receptor potential vanilloid type 5 (TRPV5), via the protein kinase A pathway
    Eline A E van der Hagen
    From the Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 289:18489-96. 2014
    ..These data explicate a calciotropic role in addition to the inotropic property of β1-AR. ..
  40. pmc β1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo
    Youde Jiang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN
    Mol Vis 20:872-80. 2014
    ..Determine whether Compound 49b treatment ameliorates retinal changes due to the lack of β2-adrenergic receptor signaling...
  41. pmc Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling
    Xiangsheng Yang
    From the Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston X Yang, X L, X Yue, J C Department of Molecular Physiology and Biophysics and Medicine Cardiology T W, Q W, G W, D Y C, X H T W and Department of Pediatrics, Texas Children s Hospital C Y M, Baylor College of Medicine, Houston, TX Department of Pharmacology, University of California at Davis Q F and Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL X A
    Circ Res 116:e1-e10. 2015
    ..Rnd3, a small Rho GTPase, is involved in the regulation of cell actin cytoskeleton dynamics, cell migration, and proliferation. The biological function of Rnd3 in the heart remains unexplored...
  42. doi MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1
    Naama Volk
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich 80804, Germany, and
    J Neurosci 34:15070-82. 2014
    ..Bioinformatics analysis revealed the adrenergic receptor β-1 (Adrb1) as a potential target for this microRNA with multiple conserved seed sites...
  43. pmc Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages
    Ilana Gabanyi
    Laboratory of Mucosal Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA Department of Pathology, School of Veterinary Medicine, Avenue Prof Orlando Marques de Paiva 87, Cidade Universitaria, University of Sao Paulo, 05508 270 São Paulo, Brazil
    Cell 164:378-91. 2016
    ..Our results reveal unique intra-tissue macrophage specialization and identify neuro-immune communication between enteric neurons and macrophages that induces rapid tissue-protective responses to distal perturbations...
  44. pmc BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes
    Arthur M Feldman
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Mol Cell Cardiol 92:10-20. 2016
    ....
  45. ncbi Primary structure of the mouse beta 1-adrenergic receptor gene
    J R Jasper
    Department of Pediatrics, Stanford University, CA 94305
    Biochim Biophys Acta 1178:307-9. 1993
    ..7% identical to the human sequence, 98.5% identical to the rat sequence, and contains a consensus site for N-linked glycosylation at Asn-15 and a cAMP-dependent protein kinase phosphorylation site at Ser-301...
  46. doi Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  47. pmc Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes
    Mingming Zhao
    Department of Pediatrics, Stanford University, Stanford, California 94304, USA
    Am J Physiol Heart Circ Physiol 301:H1461-70. 2011
    ..Angiogenesis is not a prerequisite for compensated cardiac hypertrophy...
  48. pmc β-Adrenergic receptor-PI3K signaling crosstalk in mouse heart: elucidation of immediate downstream signaling cascades
    Weizhi Zhang
    Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    PLoS ONE 6:e26581. 2011
    ....
  49. pmc Norepinephrine and ß₁-adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval
    C F Murchison
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroscience 181:109-16. 2011
    ....
  50. pmc Intracellular fatty acids suppress β-adrenergic induction of PKA-targeted gene expression in white adipocytes
    Emilio P Mottillo
    Center for Integrative Metabolic and Endocrine Research, Department of Pathology and Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Endocrinol Metab 301:E122-31. 2011
    ..Overall, our results demonstrate that fatty acids limit the upregulation of β-AR-responsive genes in white adipocytes and suggest that limiting lipolysis may be a novel means of enhancing β-AR signaling...
  51. pmc Redundant catecholamine signaling consolidates fear memory via phospholipase C
    Ming Ouyang
    Department of Pharmacology and Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 32:1932-41. 2012
    ..The results support recent evidence indicating that blocking β-adrenergic receptors alone shortly after trauma may not be sufficient to prevent PTSD...
  52. pmc β-adrenergic receptor mediation of stress-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: roles for β1 and β2 adrenergic receptors
    Oliver Vranjkovic
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53201, USA
    J Pharmacol Exp Ther 342:541-51. 2012
    ..p.) induced reinstatement in wild-type, but not β- adrenergic receptor-deficient Adrb1/Adrb2 double-knockout, mice. In contrast, cocaine administration (15 mg/kg i.p...
  53. doi Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M(2) KO animals
    Jan Benes
    Institute of Physiology, 1st Faculty of Medicine, Charles University, Albertov 5, 128 00, Prague, Czech Republic
    Naunyn Schmiedebergs Arch Pharmacol 385:1161-73. 2012
    ..As possible mechanisms of almost normal cardiac function, the decreases of both β(1)- and β(2)-adrenoceptor gene expression and receptor binding should be considered...
  54. pmc Total beta-adrenoceptor knockout slows conduction and reduces inducible arrhythmias in the mouse heart
    Florian Stöckigt
    Department of Medicine Cardiology, University Hospital of Bonn, Bonn, Germany
    PLoS ONE 7:e49203. 2012
    ..TKO represents a unique mouse model mimicking total unselective medical β-blocker therapy in men. Electrophysiological characteristics of TKO have not yet been investigated in an animal model...
  55. ncbi A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus
    J M Rochelle
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 14:26-31. 1992
    ....
  56. pmc Chromosomal organization of adrenergic receptor genes
    T L Yang-Feng
    Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 87:1516-20. 1990
    ..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules...
  57. ncbi Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus
    S A Keller
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618
    Genomics 23:309-20. 1994
    ..This deletion, Del(19)TgN8052Mm, will be useful for genetic and functional studies of this region of mouse Chromosome 19...
  58. ncbi Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1
    T Nabika
    Department of Laboratory Medicine, Shimane Medical University, Izumo, 693, Japan
    Mamm Genome 8:215-7. 1997
  59. ncbi Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes
    K E Hadri
    INSERM Unité 282, Hopital Henri Mondor, 94010 Creteil, France
    J Biol Chem 272:24514-21. 1997
    ..These findings demonstrate a differential modulation by TNF-alpha of the three beta-adrenoreceptor subtypes in adipocytes, which may contribute to metabolic disorders induced by the cytokine in the adipocyte...
  60. ncbi Alterations in dynamic heart rate control in the beta 1-adrenergic receptor knockout mouse
    D K Rohrer
    Department of Pediatrics, Stanford University, California 94305, USA
    Am J Physiol 274:H1184-93. 1998
    ..Thus, in mice, the beta 1-AR is not essential for either maintenance of resting heart rate or for maximally stressed cardiovascular performance...
  61. ncbi Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice
    W J Koch
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Trends Cardiovasc Med 9:77-81. 1999
    ..Signaling through beta ARs can be dampened by the actions of the beta AR kinase, a kinase whose expression and activity are elevated in chronic human heart failure...
  62. ncbi A putative beta2-adrenoceptor from the rainbow trout (Oncorhynuchus mykiss). Molecular characterization and pharmacology
    J G Nickerson
    Department of Biology, University of Ottawa, Ontario, Canada
    Eur J Biochem 268:6465-72. 2001
    ....
  63. ncbi A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse
    Craig J Daly
    Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland
    Physiol Genomics 9:85-91. 2002
    ....
  64. ncbi Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy
    Andrea D Eckhart
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 34:669-77. 2002
    ....
  65. ncbi betaAR signaling required for diet-induced thermogenesis and obesity resistance
    Eric S Bachman
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 297:843-5. 2002
    ..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity...
  66. ncbi Acute cold/restraint stress inhibits host resistance to Listeria monocytogenes via beta1-adrenergic receptors
    Ling Cao
    Wadsworth Center, New York State Department of Health, Empire State Plaza, 12201 0509, Albany, NY, USA
    Brain Behav Immun 17:121-33. 2003
    ....
  67. ncbi PKC-alpha regulates cardiac contractility and propensity toward heart failure
    Julian C Braz
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Nat Med 10:248-54. 2004
    ..Thus, PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca(2+) and signal transduction events, which can profoundly affect propensity toward heart failure...
  68. ncbi Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor
    Lorenz Lehr
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    FEBS Lett 576:179-82. 2004
    ..Our data are the first report of a regulation by the beta3-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis...
  69. ncbi Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos
    Stefan Cikos
    Institute of Animal Physiology, Slovak Academy of Sciences, Soltesovej 4, Kosice, Slovakia
    Mol Reprod Dev 71:145-53. 2005
    ..Thus, our results indicate that beta adrenergic receptors are expressed in mouse oocytes and preimplantation embryos and that ligands for the receptors can affect the mouse embryo even in the very early stages of development...
  70. ncbi Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice
    Geneviève Tavernier
    Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard IFR31, CHU Rangueil, Batiment L3, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Pharmacol 68:793-9. 2005
    ..We conclude that the residual lipolytic effect observed in beta-less mice can be attributed to an unknown Gs-protein-coupled receptor with low affinity for catecholamines...
  71. ncbi Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility
    Wei Zhong Zhu
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Circ Res 97:244-51. 2005
    ....
  72. pmc Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy
    Giovanni Fajardo
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    J Mol Cell Cardiol 40:375-83. 2006
    ..beta2-AR subtypes in knockout mice are recapitulated in myocytes isolated from these mice. beta2-ARs appear to play a cardioprotective role, whereas beta1-ARs a cardiotoxic role...
  73. ncbi Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury
    Shahab A Akhter
    Department of Surgery, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Heart Circ Physiol 290:H1427-32. 2006
    ..Thus genetic variation of the human beta(1)-AR may play a role in cardiac functional recovery after ischemic injury...
  74. ncbi Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2433-42. 2006
    ..those for vesicular monoamine transporter 2 (VMAT2, slc18a2), alpha 2A adrenergic receptor (adra2a), and beta 1 adrenergic receptor (adrb1)...
  75. ncbi Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes
    Benoit Boivin
    Centre de Recherche, Institut de Cardiologie de Montreal, Canada
    Cardiovasc Res 71:69-78. 2006
    ..We sought to determine if different beta-adrenergic receptor (betaAR) subtypes, and their associated signalling machinery, are functionally localized to nuclear membranes...
  76. ncbi Characterization of cardiopulmonary function and cardiac muscarinic and adrenergic receptor density adaptation in C57BL/6 mice with chronic Trypanosoma cruzi infection
    N N Rocha
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Parasitology 133:729-37. 2006
    ....
  77. ncbi Sema3a maintains normal heart rhythm through sympathetic innervation patterning
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 13:604-12. 2007
    ..We conclude that appropriate cardiac Sema3a expression is needed for sympathetic innervation patterning and is critical for heart rate control...
  78. ncbi An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Endocrinology 148:3441-8. 2007
    ..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise...
  79. ncbi Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptors
    Soo Mi Kim
    National Institute of Digestive and Diabetes and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Hypertension 50:103-9. 2007
    ....
  80. ncbi Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes
    Yongyu Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61822, USA
    J Biol Chem 283:1799-807. 2008
    ..This study not only helps us understand the endogenous agonist-dependent beta(2)AR signaling in animal heart but also offers an example of how G protein-coupled receptor signaling may be finely regulated by GRK in physiological settings...
  81. pmc Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4
    Wito Richter
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    EMBO J 27:384-93. 2008
    ....
  82. doi Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
    S J Swoap
    Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
    Am J Physiol Heart Circ Physiol 294:H1581-8. 2008
    ..These experiments conclusively demonstrate that in the absence of cold stress, regulation of vagal tone and modulation of intrinsic rate are important determinants of HR control in the mouse...
  83. pmc Persistence of circadian variation in arterial blood pressure in beta1/beta2-adrenergic receptor-deficient mice
    Soo Mi Kim
    National Institute of Digestive and Diabetes and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1427-34. 2008
    ..Our results also confirm that locomotor activity contributes strongly to circadian variation in blood pressure in mice...
  84. pmc HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification
    Carley A E Shaut
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 4:e1000073. 2008
    ....
  85. pmc Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    J Neurosci 28:6642-51. 2008
    ....
  86. pmc Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 150:144-52. 2009
    ..Our findings also suggest direct positive effects of weight and/or leptin on bone turnover and cortical bone structure, independent of adrenergic signaling...
  87. doi cAMP-mediated beta-adrenergic signaling negatively regulates Gq-coupled receptor-mediated fetal gene response in cardiomyocytes
    Mario Patrizio
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Mol Cell Cardiol 45:761-9. 2008
    ....
  88. doi Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction
    Geertje Lewin
    Institute of Pharmacology and Toxicology, University of Munster, Munster, Germany
    Circulation 119:79-88. 2009
    ....
  89. pmc Calmodulin kinase II is required for fight or flight sinoatrial node physiology
    Yuejin Wu
    Departments of Internal Medicine and Molecular Physiology and Biophysics, University of Iowa, 2256 CBRB, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:5972-7. 2009
    ....
  90. pmc Differential contribution of beta-adrenergic receptors expressed on radiosensitive versus radioresistant cells to protection against inflammation and mortality in murine endotoxemia
    Jill Walker-Brown
    Departments of Medicine and Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Shock 32:541-7. 2009
    ..Finally, we determined that beta3-AR subtype does not play a significant role in regulating LPS-mediated mortality and inflammation by evaluating mice lacking the beta1- and beta2-AR subtypes only...
  91. pmc beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes
    Santhosh K Mani
    Division of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty Street, Box 250773, Charleston, SC 29425, USA
    J Mol Cell Cardiol 48:342-51. 2010
    ..In conclusion, this work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart...
  92. pmc {beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways
    Wei Wang
    Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China
    Am J Physiol Heart Circ Physiol 299:H322-31. 2010
    ..Our results suggest that catecholamines induce myocyte necrosis primarily through beta(1)-AR-mediated increases in I(Ca-L), but other mechanisms are also involved in rodents...
  93. pmc FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes
    Shubai Liu
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 404:581-6. 2011
    ..Together, this new PKA activity biosensor provides a useful tool to directly visualize the dynamic regulation of PKA activity on the SR in cardiomyocytes under various physiological and clinical conditions...
  94. pmc Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice
    Stephanie L Catus
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 162:1700-15. 2011
    ..The aims of the present study are to identify which β-adrenoceptor subtypes are present in mouse astrocytes, the signal transduction mechanisms involved and whether β-adrenoceptor stimulation regulates glucose uptake...
  95. pmc Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation
    Qi Chen
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 286:4349-56. 2011
    ..Abnormal β(2)-AR activation at early pregnancy provided a molecular clue in explaining how maternal stress at early stages could adversely affect the pregnancy outcome...
  96. pmc Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo
    Thomas Pulinilkunnil
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 286:8798-809. 2011
    ..Furthermore, AMPK α Ser(485/491) phosphorylation may be a novel mechanism to inhibit AMPK activity in vivo and alter its biological effects...
  97. doi Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors
    Björn Neubauer
    Physiologisches Institut, Universitat Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 301:F71-7. 2011
    ..Furthermore, β-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development...
  98. pmc Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling
    Keith Schutsky
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 31:14172-81. 2011
    ..These results demonstrate that the β(2) receptor can be a critical effector of acute stress, and that β(1) and β(2) receptors can have quite distinct roles in CNS signaling and cognition...
  99. ncbi Corrected centromere orientation for mouse chromosome 19 MIT markers
    E M Eicher
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 4:223-5. 1993
  100. ncbi Genetic maps of polymorphic DNA loci on rat chromosome 1
    Y P Ding
    Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:320-7. 1996
    ..for five genes, gamma-aminobutyric acid receptor beta3 (Gabrb3), syntaxin 2 (Stx2), adrenergic receptor beta1 (Adrb1), carcinoembryonic antigen gene family member 1 (Cgm1), and lipogenic protein S14 (Lpgp), and 20 anonymous loci ..
  101. pmc Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse
    K Asai
    Weis Center for Research, Penn State College of Medicine, Danville, Pennsylvania 17822, USA
    J Clin Invest 104:551-8. 1999
    ..This study indicates that chronic sympathetic stimulation over an extended period is deleterious and results in cardiomyopathy. Conversely, beta-AR blockade is salutary in this situation and can prevent the development of cardiomyopathy...

Research Grants7

  1. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  2. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
  3. When Belief Becomes False Memory: A Processing Account
    Daniel Bernstein; Fiscal Year: 2003
    ..The proposed work will help clarify the relationship between belief and memory, thereby delineating some of the mechanisms responsible for false memory. ..
  4. Microcomputed Tomography Device (Scanco UCT40)
    Mary Bouxsein; Fiscal Year: 2004
    ..abstract_text> ..
  5. High Resolution Ultrasound Biomicroscopy System
    Daniel Bernstein; Fiscal Year: 2005
    ....
  6. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2008
    ..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
  7. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2010
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..