Adora1

Summary

Gene Symbol: Adora1
Description: adenosine A1 receptor
Alias: A1-AR, A1AR, A1R, AA1R, AI848715, BB176431, adenosine receptor A1
Species: mouse

Top Publications

  1. ncbi Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons
    Clotilde Lauro
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza BEMM, Universita Sapienza, Roma
    J Immunol 180:7590-6. 2008
  2. pmc Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27
    Richard A Fenton
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 298:H1671-8. 2010
  3. ncbi Transgenic overexpression of cardiac A(1) adenosine receptors mimics ischemic preconditioning
    R R Morrison
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 279:H1071-8. 2000
  4. pmc Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal
    Christa J Van Dort
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Neurosci 29:871-81. 2009
  5. pmc A(1) adenosine receptor-mediated PKC and p42/p44 MAPK signaling in mouse coronary artery smooth muscle cells
    Habib R Ansari
    Department of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, Robert C Byrd Health Science Center, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 297:H1032-9. 2009
  6. ncbi Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5
    S A Rivkees
    Yale University School of Medicine, Division of Pediatric Endocrinology, New Haven, Connecticut 06520, USA
    J Biol Chem 274:14204-9. 1999
  7. ncbi Ontogeny of humoral heart rate regulation in the embryonic mouse
    G A Porter
    Division of Cardiology, Yale University School of Medicine, 464 Congress Ave, New Haven, CT 06520, USA
    Am J Physiol Regul Integr Comp Physiol 281:R401-7. 2001
  8. pmc Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor
    B Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:9407-12. 2001
  9. pmc Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors
    D Sun
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:9983-8. 2001
  10. pmc A1 adenosine receptors mediate hypoxia-induced ventriculomegaly
    Christopher P Turner
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:11718-22. 2003

Research Grants

  1. Biochemical Modulation of Nociceptive Circuits
    MARK JOHN ZYLKA; Fiscal Year: 2010
  2. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
  3. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
  4. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
  5. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
  6. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
  7. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
  8. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
  9. Ischemia-Reperfusion in A2A and A2B Knockout Hearts
    R Morrison; Fiscal Year: 2007
  10. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. ncbi Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons
    Clotilde Lauro
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza BEMM, Universita Sapienza, Roma
    J Immunol 180:7590-6. 2008
    ..We demonstrate that (i) CX(3)CL1, along with AR(1), are critical players for counteracting Glu-mediated neurotoxicity in the brain and (ii) AR(1) mediates neuromodulatory action of CX(3)CL1 on hippocampal neurons...
  2. pmc Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27
    Richard A Fenton
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 298:H1671-8. 2010
    ..Attenuation of beta-adrenergic-induced contractile function by A(1)R may involve the activation of p38 MAPK, but not HSP27...
  3. ncbi Transgenic overexpression of cardiac A(1) adenosine receptors mimics ischemic preconditioning
    R R Morrison
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 279:H1071-8. 2000
    ....
  4. pmc Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal
    Christa J Van Dort
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Neurosci 29:871-81. 2009
    ..The results provide novel evidence that adenosine A(1) receptors within the prefrontal cortex comprise part of a descending system that inhibits wakefulness...
  5. pmc A(1) adenosine receptor-mediated PKC and p42/p44 MAPK signaling in mouse coronary artery smooth muscle cells
    Habib R Ansari
    Department of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, Robert C Byrd Health Science Center, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 297:H1032-9. 2009
    ..We conclude that A(1)AR stimulation by ENBA activates the PKC-alpha signaling pathway, leading to p42/p44 MAPK phosphorylation in CASMCs...
  6. ncbi Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5
    S A Rivkees
    Yale University School of Medicine, Division of Pediatric Endocrinology, New Haven, Connecticut 06520, USA
    J Biol Chem 274:14204-9. 1999
    ..To understand the biologic basis of A1AR expression, a genomic fragment containing the murine A1AR promoter was cloned...
  7. ncbi Ontogeny of humoral heart rate regulation in the embryonic mouse
    G A Porter
    Division of Cardiology, Yale University School of Medicine, 464 Congress Ave, New Haven, CT 06520, USA
    Am J Physiol Regul Integr Comp Physiol 281:R401-7. 2001
    ..0. These results identify the adenosinergic system as the earliest and most potent regulator of embryonic cardiac function and show that prenatal responsiveness to catecholamines and acetylcholine develops at later embryonic stages...
  8. pmc Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor
    B Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:9407-12. 2001
    ..However, under pathophysiological conditions, including noxious stimulation and oxygen deficiency, they are important...
  9. pmc Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors
    D Sun
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:9983-8. 2001
    ..supply through the A2 class of adenosine receptors and reducing oxygen demand through A1 adenosine receptors (A1AR)...
  10. pmc A1 adenosine receptors mediate hypoxia-induced ventriculomegaly
    Christopher P Turner
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:11718-22. 2003
    ..Using mice that are deficient in the A1AR gene (A1AR-/-), we show that A1ARs play a prominent role in the development of hypoxia-induced ventriculomegaly in ..
  11. ncbi A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion
    H Thomas Lee
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia Univ, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 286:F298-306. 2004
    ..b>A1 AR knockout mice (A1KO) or their wild-type littermate controls (A1WT) were subjected to 30 min of renal ischemia...
  12. ncbi The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors
    Linda Halldner
    Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Neuropharmacology 46:1008-17. 2004
    ..We wanted to elucidate the role of the adenosine A(1) receptor (A1R) in mediating the locomotor effects of increasing doses of caffeine using wild-type mice (A1R(WT)), mice ..
  13. ncbi Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro
    Tomas Olsson
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University, BMC A13, SE 221 84, Sweden
    Eur J Neurosci 20:1197-204. 2004
    ..to be neuroprotective due to its inhibitory effect on synaptic transmission mediated by the adenosine A1 receptor (A1R)...
  14. pmc Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 114:634-42. 2004
    ..We conclude that the generation of adenosine at the glomerular pole depends to a major extent on e-5'NT/CD73-mediated dephosphorylation of 5'-AMP, presumably generated from released ATP...
  15. ncbi Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance
    Melissa E Reichelt
    Heart Foundation Research Centre, Griffith University, Southport, QLD, Australia
    Circ Res 96:363-7. 2005
    ..Genetically modified mice were used to examine effects of global A1 adenosine receptor (A1AR) knockout (KO) on function and ischemic tolerance in perfused mouse hearts...
  16. ncbi Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
    ..Thus, caffeine-induced wakefulness depends on adenosine A2A receptors...
  17. ncbi Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Circulation 115:1581-90. 2007
    ..Once generated, adenosine can activate cell-surface adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR)...
  18. ncbi Adenosine, an endogenous distress signal, modulates tissue damage and repair
    B B Fredholm
    Department of Physiology and Pharmacology, Karolinska Insitutet, Stockholm, Sweden
    Cell Death Differ 14:1315-23. 2007
    ..This review will briefly summarize what is known and what is not in this regard. It is argued that drugs targeting adenosine receptors might be useful adjuncts in many therapeutic approaches...
  19. ncbi Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors
    J N Yang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:63-75. 2007
    ..To examine cardiac function, body temperature and locomotor behaviour in the awake adenosine A(1) receptor knock out mouse of both sexes...
  20. ncbi Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes in the antilipolytic actions of PGE2 and nicotinic acid
    S M Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:87-96. 2007
    ..We examined whether compensatory changes after adenosine A(1) receptor knockout [A(1)R (-/-)] eliminate the antilipolytic actions mediated by this receptor...
  21. pmc A1 adenosine receptors play an essential role in protecting the embryo against hypoxia
    Christopher C Wendler
    Section of Developmental Endocrinology and Biology, Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:9697-702. 2007
    ..These results show that short periods of hypoxia during early embryogenesis can result in intrauterine growth retardation. We identify adenosine and A(1)ARs as playing an essential role in protecting the embryo from hypoxia...
  22. ncbi A1 receptor deficiency causes increased insulin and glucagon secretion in mice
    Stina M Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochem Pharmacol 74:1628-35. 2007
    ..In conclusion, the A(1)R minimally affects muscle glucose uptake, but is important in regulating pancreatic islet function...
  23. ncbi Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors
    Jin Deok Joo
    Dept of Anesthesiology, Anesthesiology Research Laboratories, Columbia Univ, P and S Box 46 PH 5 630 West 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 293:F1847-57. 2007
    ..Therefore, transient activation of renal A(1)AR led to acute as well as delayed protective effects against renal IR injury via distinct signaling pathways...
  24. pmc A2B adenosine receptor dampens hypoxia-induced vascular leak
    Tobias Eckle
    Departments of Anesthesiology and Intensive Care, Tubingen University Hospital, Tubingen, Germany
    Blood 111:2024-35. 2008
    ..Here, we examined the contribution of individual adenosine receptors (ARs: A1AR/A2AAR/A2BAR/A3AR) to vascular leak induced by hypoxia...
  25. pmc Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury
    Robert Faulhaber-Walter
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 4D51, 10 Center Drive, MSC 1370, Bethesda, MD 20892, USA
    J Am Soc Nephrol 19:722-30. 2008
    ..A1 adenosine receptor (A1AR) null mice lack a TGF response, so this model was used to investigate the contribution of TGF to hyperfiltration in ..
  26. pmc The reno-vascular A2B adenosine receptor protects the kidney from ischemia
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 5:e137. 2008
    ..Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP)...
  27. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
    ..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury...
  28. doi Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin
    Stina M Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 597:92-101. 2008
    ..We have examined the role of adenosine and its interactions with insulin in adipose tissue by using A1R knock out (-/-) mice...
  29. pmc Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine
    Mark J Zylka
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, CB 7545, Chapel Hill, NC 27599, USA
    Neuron 60:111-22. 2008
    ..Our studies reveal molecular and physiological functions for PAP in purine nucleotide metabolism and nociception and suggest a novel use for PAP in the treatment of chronic pain...
  30. pmc Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injury
    Minjae Kim
    Department of Anesthesiology, Columbia University, New York, NY, USA
    Kidney Int 75:809-23. 2009
    Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia-reperfusion injury suggesting that receptor activation is protective in vivo...
  31. pmc Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine
    Jiang Ning Yang
    Karolinska Institutet, Nanna Svartz vag 2, Stockholm S 171 77 Sweden
    Am J Physiol Heart Circ Physiol 296:H1141-9. 2009
    ..The A(2A)R plays an important role in the modulation of O(2)C and LA by acute and chronic caffeine administration. There is also evidence for effects of higher doses of caffeine being independent of both A(1)R and A(2A)R...
  32. doi Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin
    Albert Salehi
    Department of Clinical Science, CRC, University of Lund, Malmo, Sweden
    Life Sci 85:470-6. 2009
    ..Extracellular ATP modulates pulsatile release of insulin, glucagon and somatostatin by activating P2Y(1) receptors. The present study examines if adenosine via A(1) receptors (A(1)R) interferes with pulsatile islet hormone release...
  33. pmc Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo
    Michael Koeppen
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, USA
    PLoS ONE 4:e6784. 2009
    ..While adenosine can signal through any of four ARs (A1AR, A2AAR, A2BAR, A3AR), previous ex vivo studies implicated the A1AR in the heart-rate slowing effects...
  34. pmc Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, Chapel Hill, North Carolina 27599, USA
    J Neurosci 30:10282-93. 2010
    ..This tone regulates how effectively acute nociceptive insults promote the transition to chronic pain...
  35. pmc Caffeine acts via A1 adenosine receptors to disrupt embryonic cardiac function
    Daniela L Buscariollo
    Section of Developmental Endocrinology and Biology, Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e28296. 2011
    ..During embryogenesis, A1ARs are the dominant regulator of heart rate, and A1AR activation reduces heart rate. Adenosine action is inhibited by caffeine, which is widely consumed during pregnancy...
  36. doi Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice
    Gary K Yang
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Endocrinol Metab 303:E180-90. 2012
    ..In conclusion, A(1) receptors in the pancreas are involved in regulating the temporal patterns of insulin release, which could have implications in the development of glucose intolerance seen in T2DM...
  37. pmc Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine
    Jiang Ning Yang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Appl Physiol (1985) 106:631-9. 2009
    ..Thus at least some aspects of long-term caffeine use can be mimicked by genetic manipulation of the A(1)R and A(2A)R...
  38. ncbi A1 adenosine receptor of human and mouse adipose tissues: cloning, expression, and characterization
    I Tatsis-Kotsidis
    Institute of Human Nutrition and Department of Microbiology, Columbia University, New York, NY 10032, USA
    Biochem Pharmacol 58:1269-77. 1999
    ..In both studies, cellular environment had no affect on binding characteristics. This conclusive evidence resolves earlier conflicting reports in the literature...
  39. ncbi Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate
    Lydia Gimenez-Llort
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Eur J Neurosci 16:547-50. 2002
    ..These results confirm the involvement of adenosine in motor activity, exploratory behaviour, anxiety and aggressiveness. A1Rs also appear to play a critical role in ageing-related deterioration...
  40. ncbi Osmotic diuretics induce adenosine A1 receptor expression and protect renal proximal tubular epithelial cells against cisplatin-mediated apoptosis
    Sandeep C Pingle
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    J Biol Chem 279:43157-67. 2004
    ..Adenosine A1 receptor (A1AR) subtype present on renal proximal tubular epithelial and cortical collecting duct cells mediates the antidiuretic ..
  41. ncbi Diabetes-induced hyperfiltration in adenosine A(1)-receptor deficient mice lacking the tubuloglomerular feedback mechanism
    J Sallstrom
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Acta Physiol (Oxf) 190:253-9. 2007
    ..In this study, we investigated the role of TGF in diabetes-induced glomerular hyperfiltration by inducing diabetes in adenosine A(1)-receptor knockout (A1AR(-/-)) mice known to lack a functional TGF mechanism.
  42. doi Adenosine primes resting stage dendritic cells before their activation
    Tracy L Flach
    Immunology Research Group and Department of Microbiology and Infectious Diseases, 4A18 HRIC, 3330 Hospital Dr NW, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Biochem Biophys Res Commun 380:748-51. 2009
    ..This effect is mediated by cAMP signaling. Our report suggests that there is a specific regulatory mechanism used by DCs to overcome adenosine mediated inhibition to become fully activated despite a general suppressive state...
  43. pmc Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice
    M Lee Haselkorn
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 27:901-10. 2010
    ..A(1)AR activation is an endogenous inhibitor of the microglial response to TBI, likely via inhibition of proliferation, and this may represent a therapeutic avenue to modulate microglia after TBI...
  44. ncbi [Brain injury in adenosine A1 receptor knock-out mice after pentetrazole kindling and its correlation with COX-2]
    Hui cong Kang
    Neurology Department of Tongji Hospital Affiliated to Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China
    Zhonghua Yi Xue Za Zhi 89:2634-8. 2009
    ....
  45. pmc Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease
    Danqing Xiao
    MassGeneral Institute for Neurolodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
    Brain Res 1367:310-8. 2011
    ..Our findings raise the possibility that A₁ or A(₂A) receptors blockade might also confer a disease-modifying benefit of reduced risk of disabling LID, whereas the effect of their combined inactivation is less clear...
  46. pmc Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans
    Robert A Figler
    Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 60:669-79. 2011
    ..To determine the mechanisms by which blockade of adenosine A(2B) receptors (A(2B)Rs) reduces insulin resistance...
  47. pmc Regulation of ethanol-sensitive EAAT2 expression through adenosine A1 receptor in astrocytes
    Jinhua Wu
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 406:47-52. 2011
    ..In addition, forskolin blocked ethanol-induced EAAT2 upregulation. Taken together, these results suggest that A1 receptor-mediated signaling regulates EAAT2 expression in astrocytes...
  48. doi Adenosine A1 receptor activation is arrhythmogenic in the developing heart through NADPH oxidase/ERK- and PLC/PKC-dependent mechanisms
    Elodie Robin
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, CH 1005, Switzerland
    J Mol Cell Cardiol 51:945-54. 2011
    ..These results suggest that pacemaking and conduction disturbances are induced via A(1)AR through concomitant stimulation of NADPH oxidase and PLC, followed by downstream activation of ERK and PKC with LCC as possible target...
  49. pmc Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells
    Sergey Ryzhov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
    J Immunol 187:6120-9. 2011
    ..We propose that generation of adenosine by CD73 expressed at high levels on granulocytic MDSCs may promote their expansion and facilitate their immunosuppressive activity...
  50. doi Adenosine A₁ receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes
    Ming Yang
    Department of Biology, Gilead Sciences, Inc, 7601 Dumbarton Circle, Fremont, CA 94555, USA
    Eur J Pharmacol 683:332-9. 2012
    ..Taken together, our data suggest that the expression of adenosine A₁ receptor is too low to play a major role in the regulation of lipogenic gene expression in hepatocytes...
  51. pmc Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia
    Sang W Park
    Department of Anesthesiology, Columbia University, New York, New York 10032 3784, USA
    Kidney Int 82:878-91. 2012
    ..Thus, proximal tubule SK1 has a critical role in A(1)AR-mediated protection against renal ischemia-reperfusion injury...
  52. doi Excessive penile norepinephrine level underlies impaired erectile function in adenosine A1 receptor deficient mice
    Chen Ning
    Xiangya Hospital Central South University, Department of Urology, Hangzhou, China Xiangya Hospital Central South University, Changsha, China
    J Sex Med 9:2552-61. 2012
    ..However, the specific role of adenosine and its receptors in erectile physiology and pathology is not fully understood...
  53. pmc Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices
    B E Lindquist
    Department of Neurosciences, University of New Mexico School of Medicine, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Neuroscience 223:365-76. 2012
    ....
  54. doi Loss of A(1) adenosine receptor attenuates alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice
    Ping Yang
    Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China
    Toxicol Sci 131:128-38. 2013
    ....
  55. doi Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice
    Dalila Mango
    IRCCS Fondazione Santa Lucia, Rome, Italy Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
    Exp Neurol 261:733-43. 2014
    ..The selective adenosine A1 receptor (A1R) antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), increased the frequency, but not the amplitude of ..
  56. doi Adenosine A1 receptor-dependent and independent pathways in modulating renal vascular responses to angiotensin II
    X Gao
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Acta Physiol (Oxf) 213:268-76. 2015
    ..In this context, this study investigated the contribution of A1 receptor-dependent and independent signalling mechanisms...
  57. doi Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test
    A D Victor Holanda
    Behavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, Brazil
    Life Sci 120:8-12. 2015
    ..The present study aimed to investigate the intraplantar (ipl) and central (icv) effects of neuropeptide S (NPS) in the formalin test and to evaluate the role of adenosine receptors, mainly A1 and A2A, in mediating such effects...
  58. ncbi Postnatal gene expression in the normal mouse cornea by SAGE
    Barbara Norman
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:429-40. 2004
    ..To provide a detailed gene expression profile of the normal postnatal mouse cornea...
  59. pmc Sex differences and the effects of ovariectomy on the β-adrenergic contractile response
    Victoria J McIntosh
    Department of Physiology and the Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Am J Physiol Heart Circ Physiol 301:H1127-34. 2011
    ..The β-adrenergic contractile response is greater in male hearts than females, and minor differences in the action of adenylyl cyclase or the A(1)AR may contribute to these sex differences...
  60. pmc Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice
    Dovenia S Ponnoth
    Dept of Physiology and Pharmacology, School of Medicine, West Virginia Univ, Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 302:R400-8. 2012
    ..These data suggest that, in the absence of A(2A)AR, Cyp4a induces vasoconstriction through MAPK via upregulation of A(1)AR and PKC-α...
  61. pmc Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine
    Julie K Hurt
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, United States of America
    PLoS ONE 7:e48562. 2012
    ..Taken together, our study highlights an obligatory role for PAP in the antinociceptive effects of thiamine and phosphorylated thiamine analogs, and suggests a novel phosphatase-independent function for PAP...
  62. ncbi The role of adenosine receptor engagement in murine fetal thymocyte development
    M Hamad
    Department of Medical Technology, Zarka Private University, Jordan
    APMIS 107:896-902. 1999
    ..An understanding of the cell-type-specific and developmental expression of adenosine receptors will help elucidate the mechanisms by which adenosine receptor engagement influences T-cell development...
  63. ncbi Cardioprotection by K(ATP) channels in wild-type hearts and hearts overexpressing A(1)-adenosine receptors
    J P Headrick
    The Rotary Centre for Cardiovascular Research, Griffith University Gold Coast Campus, Southport, QLD 4217 Australia
    Am J Physiol Heart Circ Physiol 279:H1690-7. 2000
    ..This functional protection occurs without modification of ischemic contracture. The data also support a role for mitochondrial K(ATP) channel activation in the pronounced cardioprotection afforded by overexpression of myocardial A(1)ARs...
  64. ncbi Adenosine modulates Mg(2+) uptake in distal convoluted tubule cells via A(1) and A(2) purinoceptors
    H S Kang
    Department of Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada V6T 1Z3
    Am J Physiol Renal Physiol 281:F1141-7. 2001
    ..We conclude that adenosine has dual effects on Mg(2+) uptake in MDCT cells through separate A(1) and A(2) purinoceptor pathways...
  65. ncbi Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, D 48129 Munster, Germany
    Am J Physiol Heart Circ Physiol 285:H145-53. 2003
    ..mammals, we studied transgenic (TG) mice with cardiac-specific overexpression of the A1 adenosine receptor (A1AR)...
  66. ncbi Attenuated renovascular constrictor responses to angiotensin II in adenosine 1 receptor knockout mice
    Pernille B Hansen
    NIDDK, NIH, Bldg 10, Rm 4 D51, 10 Center Dr MSC 1370, Bethesda, MD, USA
    Am J Physiol Regul Integr Comp Physiol 285:R44-9. 2003
    ..the renovascular constrictor effects of ANG II in the chronic and complete absence of A1 adenosine receptors (A1AR) using mice with targeted deletion of the A1AR gene...
  67. ncbi Emotional instability but intact spatial cognition in adenosine receptor 1 knock out mice
    Undine E Lang
    Department of Psychiatry, Free University of Berlin, Eschenallee 3, Berlin 14050, Germany
    Behav Brain Res 145:179-88. 2003
    ..In order to elucidate the involvement of the adenosine A1 receptor (A1AR) in spatial learning and the control of exploratory behaviour, we assessed A1AR knockout mice (A1AR-/-) and their ..
  68. ncbi Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR
    S Hashimoto
    National Institute of Diabetes, and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Acta Physiol Scand 181:455-62. 2004
    By crossing aquaporin 1 (AQP1)-/- and adenosine 1 receptor (A1AR)-/- mice, we generated an animal model that combines a proximal tubular absorption defect with absence of tubuloglomerular feedback (TGF) regulation of glomerular filtration ..
  69. ncbi Role of A1 adenosine receptors in regulation of vascular tone
    Huda E Tawfik
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Heart Circ Physiol 288:H1411-6. 2005
    ..These data suggest that activation of A(1)ARs causes contraction of vascular smooth muscle through PLC pathways and negatively modulates the vascular relaxation mediated by other adenosine receptor subtypes...
  70. ncbi Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum
    Esam Ghanem
    Department of Cell Physiology, Free University of Brussels, Brussels, Germany
    Am J Physiol Gastrointest Liver Physiol 288:G972-7. 2005
    ..stimulation of chloride secretion by adenosine in jejuna derived from mice lacking the adenosine receptors of A1 (A1R) and A2A (A(2A)R) or control littermates...
  71. ncbi A1 adenosine receptor knockout mice exhibit increased mortality, renal dysfunction, and hepatic injury in murine septic peritonitis
    George Gallos
    Department of Anesthesiology, Columbia University, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 289:F369-76. 2005
    ..We conclude that endogenous A(1)AR activation confers a protective effect in mice from septic peritonitis primarily by attenuating the hyperacute inflammatory response in sepsis...
  72. pmc Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia
    E Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuroscience 132:575-80. 2005
    ..These findings provide direct evidence that the neuroprotective role of adenosine during hypoxia depends on the rapid inhibition of synaptic transmission by the activation of presynaptic A(1) receptors...
  73. ncbi Reduced autoregulatory effectiveness in adenosine 1 receptor-deficient mice
    S Hashimoto
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Am J Physiol Renal Physiol 290:F888-91. 2006
    ..Using mice with deletion of the A(1) adenosine receptor (A1AR) gene, we tested the prediction that the absence of TGF, previously established to result from A1AR deficiency, is ..
  74. pmc Isolation and characterization of coronary endothelial and smooth muscle cells from A1 adenosine receptor-knockout mice
    Bunyen Teng
    Dept of Pharmacology, East Carolina University, Greenville, North Carolina, USA
    Am J Physiol Heart Circ Physiol 290:H1713-20. 2006
    ..Furthermore, the A(1)AR was characterized by Western blot analysis using an A(1)AR-specific antibody. To our knowledge, this is the first isolation and successful characterization of smooth muscle cells from the mouse coronary system...
  75. ncbi Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioning
    Amy R Lankford
    Dept of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 290:H1469-73. 2006
    ..These findings demonstrate that A(1)ARs are critical for protection from myocardial I/R injury and that cardioprotection with IPC is relative to the level of A(1)AR gene expression...
  76. ncbi Adenosine as a mediator of macula densa-dependent inhibition of renin secretion
    Soo Mi Kim
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg 10, Rm 4D51, 10 Center Dr, MSC 1370, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 290:F1016-23. 2006
    Adenosine acting through A(1) adenosine receptors (A1AR) has been shown previously to be required for the vasoconstriction elicited by high luminal NaCl concentrations at the macula densa (MD)...
  77. ncbi Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes
    R Ray Morrison
    Division of Critical Care Medicine, St Jude Children s Research Hospital, 332 N Lauderdale St, MS 734, Memphis, TN 38105, USA
    Am J Physiol Heart Circ Physiol 291:H1875-82. 2006
    ..Together, these data affirm the cardioprotective role of A(1)ARs and suggest that induced expression of other adenosine receptor subtypes may participate in the response to ischemia-reperfusion in isolated murine hearts...
  78. ncbi Adenosine A1 receptors are crucial in keeping an epileptic focus localized
    Denise E Fedele
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    Exp Neurol 200:184-90. 2006
    ..by a unilateral intrahippocampal kainic acid (KA) injection (1 nmol) in wild-type C57BL/6 and homozygous adenosine A1R knock out (A1R-KO) mice of the same genetic background...
  79. ncbi Nitric oxide serves as an endogenous regulator of neuronal adenosine A1 receptor expression
    Krishna A Jhaveri
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurochem 99:42-53. 2006
    ..As the expression of the adenosine A1 receptor (A1AR) is regulated by oxidative stress, we evaluated the role of NO in the regulation of A1AR expression, a G protein-..
  80. ncbi Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function
    Hajime Funakoshi
    Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Circulation 114:2240-50. 2006
    ..To evaluate the temporal relationship between AR signaling and cardiac remodeling, we studied the effects of controlled overexpression of the A1-AR using a cardiac-specific and tetracycline-transactivating factor-regulated promoter...
  81. ncbi Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite
    Timo Rieg
    Department of Medicine, University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive 9151, San Diego, CA 92161, USA
    Eur J Pharmacol 555:174-7. 2007
    ..These data reveal that adenosine A1 receptors do not contribute to caffeine consumption, but determine the effects of caffeine on fluid intake and plasma renin concentration...
  82. ncbi The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration
    Katrin Färber
    Cellular Neuroscience, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Glia 56:331-41. 2008
    ..We conclude that the co-stimulation of purinergic and adenosine receptors is a requirement for microglial migration and that the expression of cd39 controls the ATP/adenosine balance...
  83. ncbi Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor
    Lane Bekar
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    Nat Med 14:75-80. 2008
    ....
  84. doi Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart
    Eugene I Tikh
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 216:83-90. 2008
    ..These data show that A(2A)R and A(1)R regulate PP2A activity, thus suggesting an important mechanism for modulating myocardial contractility...
  85. doi Homeostatic action of adenosine A3 and A1 receptor agonists on proliferation of hematopoietic precursor cells
    Michal Hofer
    Laboratory of Experimental Hematology, Institute of Biophysics, vvi, Academy of Sciences of the Czech Republic, Kralovopolska 135, CZ 61265 Brno, Czech Republic
    Exp Biol Med (Maywood) 233:897-900. 2008
    ..The results indicate opposite effects of the two adenosine receptor agonists on proliferation of hematopoietic cells and suggest the plasticity and homeostatic role of the adenosine receptor expression...
  86. doi Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors
    Jana Sawynok
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Neurosci Lett 440:181-4. 2008
    ..the formalin test (a model of persistent pain) in wild type mice and mice lacking the adenosine A(1) receptor (A1R)...
  87. pmc Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice
    Lei Xi
    Division of Cardiology, Box 980204, Virginia Commonwealth University, 1101 East Marshall Street, Room 7 042, Richmond, VA 23298 0204, USA
    Circulation 118:S32-7. 2008
    ..However, the exact subtypes of such receptors remain controversial or uninvestigated. To this context, the purpose of present study was to determine the definitive role of adenosine A(1) and bradykinin B(1) and B(2) receptors in PostC...
  88. pmc Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle
    Zhongbing Lu
    Center for Vascular Biology, University of Minnesota, Minneapolis, MN 55455, USA
    Circulation 118:1713-21. 2008
    ..Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known...
  89. pmc Control and function of the homeostatic sleep response by adenosine A1 receptors
    Theresa E Bjorness
    Department of Psychiatry, University of Texas Southwestern, Dallas, Texas 75390, USA
    J Neurosci 29:1267-76. 2009
    ..Thus, AdoA(1)R activation is needed for normal rebound SWA, and when the SWA rebound is reduced, there is a failure to maintain working memory function, suggesting a functional role for SWA homeostasis...
  90. ncbi Adenosine A(1), A(2a), A(2b), and A(3) receptors in hematopoiesis. 2. Expression of receptor mRNA in resting and lipopolysaccharide-activated mouse RAW 264.7 macrophages
    D Streitová
    Institute of Biophysics, v v i, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Physiol Res 59:139-44. 2010
    ..Unstimulated macrophages exhibited a high expression of the A(2b) adenosine receptor mRNA. The findings are discussed from the point of view of the antiinflammatory and hematopoiesis-stimulating roles of the adenosine receptor signaling...
  91. pmc Enhanced tubuloglomerular feedback in mice with vascular overexpression of A1 adenosine receptors
    Mona Oppermann
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 297:F1256-64. 2009
    Adenosine 1 receptors (A1AR) in the kidney are expressed in the vasculature and the tubular system...
  92. doi Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice
    Jana Sawynok
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Neurosci Lett 473:178-81. 2010
    ..Our results indicate that, while adenosine A(1) receptors are not required for oxcarbazepine to produce antinociception in knockout mice, such receptors are essential in order to see caffeine reversal of this antinociceptive effect...
  93. pmc Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma
    Dovenia S Ponnoth
    Department of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 299:H81-7. 2010
    ..In conclusion, allergic A(1)WT mice showed altered vascular reactivity, increased airway hyperresponsiveness, and systemic inflammation. These data suggest that A(1)AR is proinflammatory systemically in this model of allergic asthma...
  94. pmc Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects
    Jessica E Sturgess
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Eur J Neurosci 32:143-54. 2010
    ....
  95. pmc Glomerular tubular balance is suppressed in adenosine type 1 receptor-deficient mice
    Tracy D Bell
    Dept of Medicine, Georgetown University, 4000 Reservoir Rd, Washington, DC 20057, USA
    Am J Physiol Renal Physiol 299:F1158-63. 2010
    ..In conclusion, GTB is dependent on adenosine acting on type 1 receptors in the proximal tubule. This may contribute to acute changes in Na(+) and fluid reabsorption...
  96. doi Essential role of EGFR in cardioprotection and signaling responses to A1 adenosine receptors and ischemic preconditioning
    Grant Williams-Pritchard
    Heart Foundation Research Centre, Griffith Univ, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Am J Physiol Heart Circ Physiol 300:H2161-8. 2011
    ..Myocardial survival kinase activation (Erk1/2, Akt) by A(1)AR agonism is similarly MMP/HB-EGF/EGFR dependent. Thus MMP-mediated EGFR activation appears essential to cardiac protection and signaling via A(1)ARs and preconditioning...
  97. doi Adenosine A2B receptor antagonist suppresses differentiation to regulatory T cells without suppressing activation of T cells
    Hiroko Nakatsukasa
    Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki, Noda shi, Chiba, Japan
    Biochem Biophys Res Commun 409:114-9. 2011
    ..Since A(2B) antagonist blocked differentiation to Treg without suppressing T cell activation, it is possible that blockade of A(2B) receptor would facilitate tumor immunity...
  98. pmc A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors
    Susan A Masino
    Department of Psychology and Neuroscience Program, Trinity College, Hartford, Connecticut, USA
    J Clin Invest 121:2679-83. 2011
    ..Seizures were restored by injecting either glucose (metabolic reversal) or an A1R antagonist (pharmacologic reversal)...
  99. pmc Adenosine receptor signaling modulates permeability of the blood-brain barrier
    Aaron J Carman
    Department of Microbiology and Immunology, Cornell University, College of Veterinary Medicine, Ithaca, New York 14853, USA
    J Neurosci 31:13272-80. 2011
    ..We anticipate these results will aid in drug design, drug delivery and treatment options for neurological diseases such as AD, Parkinson's disease, multiple sclerosis and cancers of the CNS...
  100. ncbi Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells
    D L Marquardt
    Department of Medicine, University of California, San Diego 92103
    J Immunol 152:4508-15. 1994
    ..Mast cells possess at least two adenosine receptor subtypes that may be differentially regulated...
  101. ncbi Changes in adenosine A1- and A2-receptor expression during adipose cell differentiation
    J D Børglum
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Mol Cell Endocrinol 117:17-25. 1996
    ..Thus, endogenous adenosine may have a bimodal action on adipose tissue metabolism mediated through stimulatory A2- and inhibitory A1-receptors, respectively, as a function of adipose conversion...

Research Grants12

  1. Biochemical Modulation of Nociceptive Circuits
    MARK JOHN ZYLKA; Fiscal Year: 2010
    ..Finally, we will test the hypothesis that this phosphatase modulates neuropathic pain behaviors in wild-type and phosphatase knockout mice. ..
  2. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  3. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We have also found that A1ARs are expressed in the brain during critical periods of development. We also find that A1Ar activation in the neonatal period leads to significant reductions in total axon volume, indicating that A1AR ..
  4. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  5. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..In addition, we find that blockade of A1 adenosine receptor (A1AR) action reduces hypoglycemia-induced neuronal death...
  6. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    We completed our original Specific Aims directed at studying the effects of Al adenosine receptor (A1AR) activation on the developing heart...
  7. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  8. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..and is an FDA approved drug; 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), which is a potent and highly selective A1AR antagonist; SCH58261, which is an A2aAR antagonist. [unreadable] SA2...
  9. Ischemia-Reperfusion in A2A and A2B Knockout Hearts
    R Morrison; Fiscal Year: 2007
    ....
  10. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  11. Scott A Rivkees; Fiscal Year: 2015
    ....
  12. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..