Adm

Summary

Gene Symbol: Adm
Description: adrenomedullin
Alias: ADM
Species: mouse

Top Publications

  1. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
  2. ncbi Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress
    Tatsuo Shimosawa
    Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hypertension 41:1080-5. 2003
  3. pmc The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity
    Yuka Ichikawa-Shindo
    Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Nagano, Japan
    J Clin Invest 118:29-39. 2008
  4. pmc Adrenomedullin signaling is necessary for murine lymphatic vascular development
    Kimberly L Fritz-Six
    Department of Cell and Molecular Physiology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 118:40-50. 2008
  5. doi Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema
    Donghao Jin
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Cardiovasc Res 80:339-45. 2008
  6. pmc Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene
    Ryan T Dackor
    Department of Cell and Molecular Physiology, CB 7545, 6330 MBRB, 103 Mason Farm Rd, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 26:2511-8. 2006
  7. ncbi Endogenous adrenomedullin protects against vascular response to injury in mice
    Junsuke Kawai
    Department of Internal Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
    Circulation 109:1147-53. 2004
  8. doi Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner
    Peiwen Chen
    National Engineering Laboratory for Anti tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, People s Republic of China
    Clin Cancer Res 17:7230-9. 2011
  9. ncbi Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene
    Hiroaki Nishimatsu
    Department of Urology, Faculty of Medicine, The University of Tokyo, Japan
    Circ Res 90:657-63. 2002
  10. ncbi Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage
    Tatsuo Shimosawa
    Department of Nephrology and Endocrinology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Circulation 105:106-11. 2002

Research Grants

Scientific Experts

  • Fredrik Lanner
  • Leonid L Nikitenko
  • Yuuki Hiradate
  • S A Hamid
  • Toshiro Fujita
  • Beverly J Paigen
  • L M Montuenga
  • Kathleen M Caron
  • Hiroshi Yamamoto
  • Regina Trollmann
  • Myriam Hemberger
  • Mercedes Garayoa
  • Takayuki Shindo
  • Manyu Li
  • Alfredo Martinez
  • Tatsuo Shimosawa
  • Teruhide Koyama
  • Takahiro Yoshizawa
  • Katsuyuki Ando
  • Ryozo Nagai
  • Yuka Ichikawa-Shindo
  • Ana P Fernández
  • William P Dunworth
  • Yasuhiro Iesato
  • Kenji Kangawa
  • Takayuki Sakurai
  • Hisaka Kawate
  • Akiko Kamiyoshi
  • Kimberly L Fritz-Six
  • Satoshi Iimuro
  • Megumu Tanaka
  • Yuichi Toriyama
  • Kyoko Igarashi
  • Ryuichi Uetake
  • Akihiro Yamauchi
  • Pei Niu
  • Hayato Kawakami
  • Claire Leconte
  • Vijaya Ramachandran
  • Yin Li
  • Kazutoshi Miyashita
  • Emmanuelle Tixier
  • Hiromitsu Matsui
  • Josune García-Sanmartín
  • Dan W Siemsen
  • Yasunobu Hirata
  • Kazuwa Nakao
  • Hiroaki Nishimatsu
  • Akihiro Tojo
  • Kazuhiro Takahashi
  • Klara R Klein
  • Scott T Espenschied
  • Helen H Willcockson
  • Lei Yang
  • Michio Hayashi
  • Gaurav Aggarwal
  • Kentaro Yuda
  • Sabine Pfister
  • Marion Hölscher
  • Peiwen Chen
  • Sylvie Lausson
  • Takakuni Maki
  • Toshinori Murata
  • Norifumi Takeda
  • Aya Ebihara
  • Hiroshi Iwata
  • Craig D Logsdon
  • Nobuyoshi Iinuma
  • Yuelan Zhang
  • Thiruvengadam Arumugam
  • O Hurtado
  • Eva Vergaño-Vera
  • Myriam Bernaudin
  • Tomoki Nagare
  • Julia Serrano
  • Donghao Jin
  • Keizo Kanasaki
  • Ryan Dackor
  • Frederic Sierro
  • Michael Miksa
  • Nobuo Moriyama
  • Cristina de Guzman Strong
  • Ryan T Dackor
  • Elena Gonzalez-Rey
  • Oliver Smithies
  • John S Lee
  • Masayo Hino
  • Megumi Fujita
  • Kwijun Park
  • Kenichi Yamahara

Detail Information

Publications87

  1. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
    ..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4...
  2. ncbi Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress
    Tatsuo Shimosawa
    Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hypertension 41:1080-5. 2003
    ....
  3. pmc The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity
    Yuka Ichikawa-Shindo
    Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Nagano, Japan
    J Clin Invest 118:29-39. 2008
    ..Our findings in human cells and in mice demonstrate that RAMP2 is a key determinant of the effects of AM on the vasculature and is essential for angiogenesis and vascular integrity...
  4. pmc Adrenomedullin signaling is necessary for murine lymphatic vascular development
    Kimberly L Fritz-Six
    Department of Cell and Molecular Physiology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 118:40-50. 2008
    ..Collectively, our studies identify a class of genes involved in lymphangiogenesis that represent a pharmacologically tractable system for the treatment of lymphedema or inhibition of tumor metastasis...
  5. doi Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema
    Donghao Jin
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Cardiovasc Res 80:339-45. 2008
    ..Lymphoedema is a common but refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether AM promotes lymphangiogenesis and improves lymphoedema...
  6. pmc Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene
    Ryan T Dackor
    Department of Cell and Molecular Physiology, CB 7545, 6330 MBRB, 103 Mason Farm Rd, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 26:2511-8. 2006
    ..The Calcrl gene targeted mice provide the first in vivo genetic evidence that CLR functions as an AM receptor during embryonic development...
  7. ncbi Endogenous adrenomedullin protects against vascular response to injury in mice
    Junsuke Kawai
    Department of Internal Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
    Circulation 109:1147-53. 2004
    ..In our previous study, adrenomedullin (AM) overexpression could limit the arterial intimal hyperplasia induced by cuff injury in rats. However, it remains to be elucidated whether endogenous AM plays a role against vascular injury...
  8. doi Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner
    Peiwen Chen
    National Engineering Laboratory for Anti tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, People s Republic of China
    Clin Cancer Res 17:7230-9. 2011
    ..However, the mechanisms by which TAMs modulate melanoma growth are still poorly understood. This study was aimed at examining the function and mechanism of TAM-derived adrenomedullin (ADM) in angiogenesis and melanoma growth.
  9. ncbi Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene
    Hiroaki Nishimatsu
    Department of Urology, Faculty of Medicine, The University of Tokyo, Japan
    Circ Res 90:657-63. 2002
    ..AM is likely to protect renal tissues from ischemia/reperfusion injury through its NO releasing activity...
  10. ncbi Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage
    Tatsuo Shimosawa
    Department of Nephrology and Endocrinology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Circulation 105:106-11. 2002
    ..Although both AM and PAMP have the potential not only to decrease blood pressure but also to protect organs from damage, there is no direct evidence for their individual physiological roles in vivo...
  11. ncbi Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene
    T Shindo
    Department of Cardiovascular Medicine, University of Tokyo, and Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan
    Circulation 104:1964-71. 2001
    ..Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice...
  12. pmc Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
    K M Caron
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 98:615-9. 2001
    ..To elucidate these functions and define more precisely sites of Adm expression, we replaced the coding region of the Adm gene in mice with a sequence encoding enhanced green ..
  13. ncbi Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action
    L M Montuenga
    Biomarkers and Prevention Research Branch, National Cancer Institute, Rockville, Maryland 20850, USA
    Endocrinology 138:440-51. 1997
    ..In several regions of the embryo, the patterns of AM expression correspond to the degree of differentiation. The possible involvement of AM in the control of embryonic invasion, proliferation, and differentiation is discussed...
  14. ncbi Angiogenic effects of adrenomedullin in ischemia and tumor growth
    Satoshi Iimuro
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Circ Res 95:415-23. 2004
    ..This may make AM a useful therapeutic tool for relieving ischemia; conversely, inhibitors of AM could be useful for clinical management of tumor growth...
  15. doi Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
    Teruhide Koyama
    Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Matsumoto, Nagano, 390 8621, Japan
    Circulation 127:842-53. 2013
    ..Our aim was to investigate the function of the vascular AM-RAMP2 system directly...
  16. pmc Vascular Dysfunction in Pneumocystis-Associated Pulmonary Hypertension Is Related to Endothelin Response and Adrenomedullin Concentration
    Dan W Siemsen
    Department of Microbiology and Immunology, Montana State University, Bozeman, Montana
    Am J Pathol 186:259-69. 2016
    ..Our results indicate the diverse mechanisms by which inflammatory responses to prior infections can cause functionally relevant changes in vascular responses in the lung, promoting the development of pulmonary hypertension. ..
  17. doi Hypoxia-induced arterial differentiation requires adrenomedullin and notch signaling
    Fredrik Lanner
    Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Huddinge, Sweden
    Stem Cells Dev 22:1360-9. 2013
    ....
  18. doi Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis
    Yasuhiro Iesato
    Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Am J Pathol 182:2380-90. 2013
    Adrenomedullin (ADM) is an endogenous peptide first identified as a strong vasodilating molecule...
  19. doi Adrenomedullin regulates club cell recovery following lung epithelial injury
    Josune García-Sanmartín
    Oncology Area, Center for Biomedical Research of La Rioja CIBIR, Logrono, Spain
    Histol Histopathol 31:663-73. 2016
    ..In conclusion, the paracrine/autocrine influence of AM in club cells subtly modulates their proliferation and spreading kinetics during lung epithelium recovery. ..
  20. pmc Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development
    Klara R Klein
    Department of Cell Biology and Physiology, The University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Cell 30:528-40. 2014
    ..underpinning for this proliferative phenotype by demonstrating that the dosage and signaling of adrenomedullin (Adm, gene; AM, protein)-a mitogenic peptide hormone required for normal cardiovascular development-is tightly ..
  21. doi Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression
    Claire Leconte
    Universite de Caen Basse Normandie, UMR 6232 CI NAPS, CERVOxy Team, Hypoxia and Cerebrovascular Pathophysiology, GIP Cyceron, F 14074 Caen, France
    Behav Brain Res 230:78-84. 2012
    ..This work shows that repeated mild hypoxic exposure decreases anxiety-related behavior and points out hypoxia inducible factor-1 (HIF-1) target genes, particularly adrenomedullin, as potential mediator candidate...
  22. pmc The role of adrenomedullin in the renal NADPH oxidase and (pro)renin in diabetic mice
    Michio Hayashi
    Department of Internal Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Diabetes Res 2013:134395. 2013
    ..The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase probably by suppressing the local renin-angiotensin system. ..
  23. pmc Adrenomedullin haploinsufficiency predisposes to secondary lymphedema
    Leonid L Nikitenko
    Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, UK
    J Invest Dermatol 133:1768-76. 2013
    ..Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the Adm gene (adrenomedullin gene)...
  24. doi Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system
    Takahiro Yoshizawa
    Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Matsumoto, Nagano, 390 8621, Japan
    Hypertension 61:341-51. 2013
    ..These data demonstrate that the AM-RAMP2 system is essential for cardiac metabolism and homeostasis. The AM-RAMP2 system is a promising therapeutic target of heart failure...
  25. pmc Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice
    Gaurav Aggarwal
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 143:1510-1517.e1. 2012
    ..New-onset diabetes in patients with pancreatic cancer is likely to be a paraneoplastic phenomenon caused by tumor-secreted products. We aimed to identify the diabetogenic secretory product(s) of pancreatic cancer...
  26. pmc Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta
    Manyu Li
    Department of Cell Biology and Physiology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 123:2408-20. 2013
    ..These data identify an essential function for fetal-derived factors in the maternal vascular adaptation to pregnancy and underscore the importance of exploring AM as a biomarker and therapeutic agent for preeclampsia...
  27. doi Adrenomedullin inhibits choroidal neovascularization via CCL2 in the retinal pigment epithelium
    Kentaro Yuda
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Am J Pathol 181:1464-72. 2012
    ..Gene expression profiling identified adrenomedullin (ADM) as a possible molecular target for the treatment of AMD and expression of ADM was upregulated in eyes with laser-..
  28. doi Adrenomedullin: a possible regulator of germinal vesicle breakdown
    Yuuki Hiradate
    Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi Aobaku, Sendai 981 8555, Japan
    Biochem Biophys Res Commun 415:691-5. 2011
    Adrenomedullin (ADM) is a multifunctional hormone that regulates processes as diverse as blood pressure and cell growth. Although expressed in the ovary, the role of ADM in this organ is not clear...
  29. doi Signal transduction pathways mediating the effect of adrenomedullin on osteoblast survival
    Sylvie Lausson
    UMR CNRS 8619, Orsay, University Pierre and Marie Curie, Paris, France
    J Cell Biochem 112:3807-15. 2011
    Adrenomedullin (ADM) plays an important role in the regulation of osteoblastic cells through both a proliferative and an anti-apoptotic effects. The present study investigated mechanisms involved in the effect of ADM on survival...
  30. pmc Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo
    William P Dunworth
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Peptides 29:2243-9. 2008
    ..Together, these data reveal a previously unrecognized role for AM in controlling lymphatic endothelial permeability and lymphatic flow through reorganization of junctional proteins...
  31. pmc Mice heterozygous for adrenomedullin exhibit a more extreme inflammatory response to endotoxin-induced septic shock
    Ryan Dackor
    Department of Cell and Molecular Physiology, CB 7545, 103 Mason Farm Road, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Peptides 28:2164-70. 2007
    ..We, therefore, conclude that during septic shock the dynamic modulation of AM and its receptors primarily functions to dampen the inflammatory response...
  32. ncbi Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    J Immunol 179:6263-72. 2007
    ..We conclude that AM/AMBP-1 is protective in sepsis due to its vasoactive properties and direct anti-inflammatory effects mediated through both the cAMP-dependent pathway and Pyk-2-ERK1/2-dependent induction of PPAR-gamma...
  33. doi Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 453:1117-21. 2008
    ....
  34. doi Adrenomedullin protects neurons against oxygen glucose deprivation stress in an autocrine and paracrine manner
    Emmanuelle Tixier
    Centre d Imagerie Neurosciences et Applications aux PathologieS CI NAPS, UMR 6232, Universite de Caen Basse Normandie, Universite Paris Descartes, CNRS, CEA, France
    J Neurochem 106:1388-403. 2008
    ..Altogether, our results suggest that adrenomedullin is an effector of the hypoxic pre-conditioning-induced neuronal tolerance and a potent autocrine and paracrine neuroprotective factor during cerebral ischaemia...
  35. pmc Haploinsufficiency for adrenomedullin reduces pinopodes and diminishes uterine receptivity in mice
    Manyu Li
    Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biol Reprod 79:1169-75. 2008
    ..Here, we further demonstrate that Adm(+/-) female mice displayed reduced pregnancy success rates that were not caused by defects in folliculogenesis, ..
  36. pmc Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions
    Ana P Fernández
    Department of Cellular, Molecular, and Developmental Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Proc Natl Acad Sci U S A 105:12581-6. 2008
    The adrenomedullin (AM) gene, adm, is widely expressed in the central nervous system (CNS) and several functions have been suggested for brain AM...
  37. doi Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction
    Takakuni Maki
    Departments of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neuroreport 22:442-7. 2011
    ..These results suggest that adrenomedullin has potential as therapy for dementia through enhancement of functional vascular growth...
  38. doi The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes
    Tomoki Nagare
    Department of Internal Medicine, Division of Diabetes, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 379:98-103. 2009
    ..These results thus implicate KLF15 in the regulation of adrenomedullin expression in adipose tissue...
  39. doi Nitric oxide/cGMP signalling mediates the cardioprotective action of adrenomedullin in reperfused myocardium
    Shabaz A Hamid
    Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK
    Basic Res Cardiol 105:257-66. 2010
    ..3%). These data provide the first evidence that AM increases NO bioavailability in intact murine myocardium and confirm that the NO/sGC/cGMP pathway is central to the cytoprotective action of AM against ischaemia-reperfusion injury...
  40. pmc The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment
    Vijaya Ramachandran
    Department of Cancer Biology, University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America
    PLoS ONE 4:e7502. 2009
    ..The current study examines the role of specific AM receptors on tumor and cells resembling the tumor microenvironment (human pancreatic stellate--HPSC, human umbilical vein-- HUVEC and mouse lung endothelial cells--MLEC)...
  41. doi Lack of adrenomedullin affects growth and differentiation of adult neural stem/progenitor cells
    Eva Vergaño-Vera
    Department of Cellular, Molecular, and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002, Madrid, Spain
    Cell Tissue Res 340:1-11. 2010
    ..we have obtained NSPC from the olfactory bulb of adult wild-type animals and brain conditional knockouts for adm, the gene that produces AM...
  42. doi Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model
    O Hurtado
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Neuroscience 171:885-92. 2010
    ..In the future, substances that increase AM actions in the central nervous system may be used as potential neuroprotective agents in stroke...
  43. doi Lack of adrenomedullin in the central nervous system results in apparently paradoxical alterations on pain sensitivity
    Ana P Fernández
    Department of Cellular, Molecular, and Developmental Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Endocrinology 151:4908-15. 2010
    Adrenomedullin (AM) is a regulatory peptide, coded by the adm gene, which is involved in numerous physiological processes, including pain sensitivity...
  44. ncbi Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene
    T Okazaki
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Genomics 37:395-9. 1996
    We have isolated and characterized the mouse adrenomedullin (AM) gene (Adm) and determined its chromosomal location. The gene spans approximately 2.1 kb and is organized into four exons separated by three introns...
  45. doi Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain
    Regina Trollmann
    Department of Pediatrics, University of Erlangen, Erlangen, Germany
    Am J Physiol Regul Integr Comp Physiol 299:R1489-99. 2010
    ..Functional activity of the HIF system was obvious from elevated expression of various known HIF target genes (Adm, Vegf, Hk2, Pdk1, Bnip3, Ier3, Dusp-1), indicating immediate availability among early response to acute hypoxia...
  46. pmc Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury
    Marion Hölscher
    Department of Cardiovascular Physiology, Universitatsmedizin Gottingen, Georg August University Gottingen, Gottingen, Germany
    J Biol Chem 286:11185-94. 2011
    ..This correlated with a decreased number of apoptotic cells in the infarcted myocardium in the cPhd2(-/-) mice and significantly improved cardiac function 3 weeks after myocardial infarction...
  47. doi Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, New South Wales, Australia
    Int J Dev Biol 55:45-58. 2011
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal...
  48. ncbi Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis
    Y Ono
    Department of Anesthesiology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Biochem Biophys Res Commun 271:197-202. 2000
    ..It is revealed that the distributions of receptor or binding sites of AM are changed in sepsis, and it is suggested that AM plays distinct roles in the clinical course of this syndrome...
  49. pmc Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males
    Kathleen Caron
    Department of Cell and Molecular Physiology and Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:3420-5. 2007
    ..These observations suggest that the effect of gender on the role of AM in counteracting cardiovascular damage in humans merits careful evaluation...
  50. ncbi Lessons from the adrenomedullin knockout mouse
    Katsuyuki Ando
    Department of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Tokyo 113 8655, Bunkyoku, Japan
    Regul Pept 112:185-8. 2003
    ..The accelerated organ damage in AM(+/-) mice was accompanied with enhanced production of oxidative stress. Thus, our data suggest that intrinsic AM play a vascular protective role...
  51. ncbi Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice
    Hiroaki Nishimatsu
    Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hypertens Res 26:S79-84. 2003
    ..AM antagonists increased vascular tone in WT as well as in TG, suggesting that endogenous AM plays a physiological role in the regulation of aortic tone...
  52. ncbi Decreased expression of adrenomedullin during adipocyte-differentiation of 3T3-L1 cells
    Yin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575 Japan
    Hypertens Res 26:S41-4. 2003
    ..The present study thus showed that AM expression was decreased, and resistin expression increased, during adipocyte-differentiation of 3T3-L1 cells...
  53. ncbi Expression and immunohistochemical localization of adrenomedullin in the mouse cochlea
    Tetsuya Tono
    Department of Otolaryngology, Miyazaki Medical College, Miyazaki, Japan
    ORL J Otorhinolaryngol Relat Spec 64:169-72. 2002
    ..These results suggest that AM may play a role in the regulation not only of cochlear hemodynamics but also of cochlear fluid dynamics...
  54. ncbi Adrenomedullin in mammalian embryogenesis
    Mercedes Garayoa
    Department of Histology and Pathology, Carcinogenesis Unit, University of Navarra, 31080 Pamplona, Spain
    Microsc Res Tech 57:40-54. 2002
    ....
  55. ncbi Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5
    G Glowacki
    Institute for Immunology, University Hospital, Martinistrasse 52, 20246 Hamburg, Germany
    Gene 275:267-77. 2001
    ..The secreted epitope-tagged ART5 protein resembled rat ART2 in exhibiting potent NAD-glycohydrolase activity. This study provides important experimental tools to further elucidate the function of ART5...
  56. ncbi The mouse Psma1 gene coding for the alpha-type C2 proteasome subunit: structural and functional analysis, mapping, and colocalization with Pde3b on mouse chromosome 7
    A Hopitzan
    Research and Development, Boehringer Ingelheim Austria, Vienna, 1121, Austria
    Genomics 66:313-23. 2000
    ..3 in a region syntenic to human chromosome 11p15. Our results extend the structural and functional analysis of genes encoding the 20S proteasome subunits and provide the basis for the study of their regulation...
  57. ncbi Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion
    Myriam Hemberger
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 227:185-91. 2003
    ..These results show that trophoblast giant cells have the intrinsic capacity to attract and increase blood flow and to gradually displace the vascular endothelium resulting in the formation of canals entirely lined by trophoblast cells...
  58. ncbi PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments
    S Xu
    Predoctoral Training Program in Human Genetics, Department of Pediatrics, Baltimore, Maryland 21205, USA
    J Biol Chem 274:35676-85. 1999
    ..This activity and subcellular location suggests that PHR1 may function as a previously unrecognized modulator of the phototransduction pathway...
  59. ncbi Characterization and chromosomal mapping of a mouse ortholog of the late-infantile ceroid-lipofuscinosis gene CLN2
    M L Katz
    Mason Eye Institute, University of Missouri School of Medicine, One Hospital Drive, Columbia, Missouri 65212, USA
    Mamm Genome 10:1050-3. 1999
    ..Characterization of the mouse Cln2 gene will facilitate generation of a mouse model for late-infantile ceroid-lipofuscinosis by gene targeting and identification of functionally important regions of the Cln2 protein...
  60. ncbi Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse
    S Yotsumoto
    Department of Internal Medicine, Wayne State University, 5047 Gullen Mall, Detroit, Michigan, 48202, USA
    Dev Biol 203:264-75. 1998
    ....
  61. ncbi Coordinate expression of transforming growth factor-beta1 and adrenomedullin in rodent embryogenesis
    L M Montuenga
    Department of Cell and Cancer Biology, National Cancer Institute, Medicine Branch, Rockville, Maryland 20850, USA
    Endocrinology 139:3946-57. 1998
    ....
  62. ncbi Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map
    H Yoshitomi
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 215:77-84. 1998
    ..As Solanes et al. reported that both human UCP2 and UCP3 genes are assigned to chromosome 11q13, the region where the mouse Ucp2 and Ucp3 are localized is syntenic to human chromosome 11q13...
  63. ncbi Novel sites of adrenomedullin gene expression in mouse and rat tissues
    V A Cameron
    The Department of Medicine, The Christchurch School of Medicine, New Zealand
    Endocrinology 139:2253-64. 1998
    ..The strong expression of AM in uterus, ovary, and posterior pituitary suggests that AM plays a role in female reproduction...
  64. ncbi Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milk
    G D Jahnke
    Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Mol Endocrinol 19:279-89. 1997
    ..These data suggest a potential role for AM and its receptor in the maintenance of mammary gland homeostasis and suggests a potential role for AM in development of the newborn...
  65. ncbi Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue
    R T White
    California Biotechnology Inc, Mountain View 94043
    J Biol Chem 267:9210-3. 1992
    ..The data presented here, demonstrating the equivalence of human adipsin to complement factor D and its high level of expression in fat, suggest a previously unsuspected role for adipose tissue in immune system biology...
  66. ncbi Expression and regulation of adrenomedullin in renal glomerular podocytes
    Masayo Hino
    Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 330:178-85. 2005
    ..These results indicated that AM expression in the podocytes was upregulated by stimuli or condition relevant to podocyte injury, suggesting its potential role in podocyte pathophysiology...
  67. ncbi Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice
    Hiroshi Yamamoto
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan 113 8655
    J Appl Physiol (1985) 102:2361-8. 2007
    Adrenomedullin (ADM), a newly identified vasodilating peptide, is reported to be expressed in lungs and have a bronchodilating effect. We hypothesized whether ADM could be involved in the pathogenesis of bronchial asthma...
  68. ncbi Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
  69. pmc Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3
    Cristina de Guzman Strong
    National Human Genome Research Institute and 2National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:661-70. 2006
    ..Comparison of these animal models illustrates how impairment of the skin barrier by two genetically distinct mechanisms leads to innate immune responses, as observed in the common human skin disorders psoriasis and atopic dermatitis...
  70. pmc Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response
    Elena Gonzalez-Rey
    Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, Avd Conocimiento, Parque Tecnologico Ciencias de la Salud, Granada 18100, Spain
    Am J Pathol 168:1921-30. 2006
    ..In conclusion, UCN and AM could represent two multistep therapeutic agents for human septic shock to be used in combination with other immunomodulatory agents or complementary as anti-inflammatory factors to other therapies...
  71. ncbi The neuroprotective and vasculo-neuro-regenerative roles of adrenomedullin in ischemic brain and its therapeutic potential
    Kazutoshi Miyashita
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Japan
    Endocrinology 147:1642-53. 2006
    ..In summary, this study suggests the neuroprotective and vasculo-neuro-regenerative roles of AM and provides basis for a new strategy to rescue ischemic brain through its multiple hormonal actions...
  72. ncbi Identification of adipocyte differentiation-related regulatory element for adrenomedullin gene repression (ADRE-AR) in 3T3-L1 cells
    Yin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Peptides 27:1405-14. 2006
    ..The present study has raised the possibility that ADRE-AR may play important roles in the AM gene expression in preadipocytes, and that the AM gene may be repressed through the ADRE-AR in adipocytes...
  73. ncbi Sympatho-inhibitory action of endogenous adrenomedullin through inhibition of oxidative stress in the brain
    Megumi Fujita
    Department of Nephrology and Endocrinology, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
    Hypertension 45:1165-72. 2005
    ..In conclusion, endogenous adrenomedullin in the brain may inhibit sympathetic activation through its antioxidant action...
  74. ncbi Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo
    Kazutoshi Miyashita
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho Sakyo ku, Japan
    FEBS Lett 544:86-92. 2003
    ..The findings suggest that AM plays significant roles in vascular regeneration, associated with PKA- and PI3K-dependent activation of Akt in endothelial cells, and possesses therapeutic potential for vascular injury and tissue ischemia...
  75. ncbi Transcriptional regulation of cardiac progenitor cell populations
    Amanda M Masino
    Department of Internal Medicine, University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8573, USA
    Circ Res 95:389-97. 2004
    ..These results define the transcriptional profile of mammalian cardiac progenitor cells and provide insight into the molecular regulation of the earliest periods of heart development...
  76. ncbi Angiotensin II-induced insulin resistance is enhanced in adrenomedullin-deficient mice
    Guangqun Xing
    Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 145:3647-51. 2004
    ....
  77. ncbi Adrenomedullin can protect against pulmonary vascular remodeling induced by hypoxia
    Hiromitsu Matsui
    Department of Nephrology and Endocrinology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Circulation 109:2246-51. 2004
    ..Thus, using heterozygous AM-knockout (AM+/-) mice, we examined whether AM could attenuate pulmonary vascular damage induced by hypoxia...
  78. ncbi Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally
    Elena Bodegas
    Oncology Division, Center for Applied Medical Research, Department of Histology and Pathology, University of Navarra, Spain
    Int J Dev Biol 48:67-70. 2004
    ..The elevated expression of adrenomedullin which occurs postnatally in the TGF-beta1 null mouse may be a cause or a consequence of the multifocal wasting syndrome which is characteristic of postnatal TGF-beta1 null mice...
  79. ncbi Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage
    Pei Niu
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circulation 109:1789-94. 2004
    ..Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice...
  80. ncbi Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice
    Pei Niu
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hypertens Res 26:731-6. 2003
    ..An improved understanding of these roles may pave the way to a novel pharmacological approach for the prevention of cardiovascular diseases...
  81. pmc Adrenomedullin upregulates M2-muscarinic receptors in cardiomyocytes from P19 cell line
    Sophie Buys
    INSERM U586, Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
    Br J Pharmacol 139:1219-27. 2003
    ..6. Our findings demonstrate that AM regulates M(2) receptors expression in cardiomyocytes probably through a mechanism involving L1/G10D receptors. The 'in vivo' significance of this phenomenon remains to be demonstrated...
  82. ncbi cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion
    M Hemberger
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Dev Biol 222:158-69. 2000
    ..The known functions of MPS1 and cathepsin L proteins indicate that the related proteins EPCS50, EPCS24, and EPCS68 participate in conferring invasive properties to the mouse trophoblast...
  83. ncbi QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice
    Fumihiro Sugiyama
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 10:5-12. 2002
    ..Identification of the genes for these QTL should lead to a better understanding of the causes of essential hypertension...
  84. ncbi A critical cytoprotective role of endogenous adrenomedullin in acute myocardial infarction
    Shabaz A Hamid
    Department of Basic Sciences, The Royal Veterinary College, University of London, UK
    J Mol Cell Cardiol 41:360-3. 2006
    ..These studies provide the first evidence that expression of AM is a critical factor regulating myocardial tolerance to ischaemia-reperfusion injury...
  85. pmc Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice
    Manyu Li
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 116:2653-62. 2006
    ..This study provides the first genetic evidence to our knowledge to suggest that a modest reduction in human AM expression during pregnancy may have an unfavorable impact on reproduction...

Research Grants1

  1. Phenotype of Genetically Reduced Adrenomedullin during Pregnancy
    Kathleen Caron; Fiscal Year: 2008
    ..Adrenomedullin (Adm) is a peptide vasodilator that has significant roles during pregnancy...