Add3

Summary

Gene Symbol: Add3
Description: adducin 3 (gamma)
Alias: AI463285, R75380, adducin-like protein 70, cytoskeletal protein, gamma-adducin
Species: mouse

Top Publications

  1. pmc γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus
    Hong Lou
    Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bldg 49, Rm 5A22, 49 Convent Drive, Bethesda, MD 20892, USA
    J Mol Neurosci 49:1-10. 2013
  2. ncbi Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes
    C Pinto-Correia
    Department of Anatomical Sciences, State University of New York, Buffalo 14214
    Dev Biol 146:301-11. 1991
  3. pmc Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice
    D M Gilligan
    Department of Internal Medicine Hematology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 96:10717-22. 1999
  4. ncbi The mouse adducin gene family: alternative splicing and chromosomal localization
    S P Suriyapperuma
    Yale University School of Medicine, 333 Cedar Street, WWW 403, New Haven, Connecticut 06510, USA
    Mamm Genome 11:16-23. 2000
  5. ncbi Expression of gamma-adducin is associated with regions of morphogenetic cell movement in the chick embryo
    Jun Akai
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Mech Dev 119:S191-5. 2002
  6. ncbi Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus
    Susanne M Clee
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nat Genet 38:688-93. 2006
  7. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
  8. pmc Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells
    Kenneth E Sahr
    The Jackson Laboratory, Bar Harbor, Maine 04606, USA
    Am J Hematol 84:354-61. 2009
  9. doi beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits
    F Porro
    ICGEB, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Genes Brain Behav 9:84-96. 2010

Scientific Experts

  • Kenneth E Sahr
  • Hong Lou
  • F Porro
  • Steven L Ciciotte
  • Narla Mohandas
  • Luanne L Peters
  • Raymond F Robledo
  • Susanne M Clee
  • D M Gilligan
  • Jun Akai
  • Andre Phillips
  • Joshua J Park
  • Y Peng Loh
  • M Rosato-Siri
  • E Leone
  • S P Suriyapperuma
  • L Costessi
  • E Tongiorgi
  • A F Muro
  • A Iaconcig
  • L L Peters
  • L Lozovatsky
  • Amy J Lambert
  • Diana M Gilligan
  • Babette Gwynn
  • Hong Lan
  • Kathryn M Schueler
  • Matthew B Young
  • Alan D Attie
  • Igor Boronenkov
  • Brian S Yandell
  • Mark P Gray-Keller
  • Mary E Rabaglia
  • Oliver C Richards
  • Daniel M Klass
  • Eric T K Mui
  • Jonathan P Stoehr
  • Donald S Stapleton
  • Philipp W Raess
  • Summer M Raines
  • Edward A Kabara
  • Matthew T Flowers
  • Kate Storey
  • S L Ciciotte
  • N Mohandas
  • C Brugnara
  • B Gwynn
  • C Pinto-Correia
  • E G Goldstein
  • J S Sobel
  • V Bennett

Detail Information

Publications9

  1. pmc γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus
    Hong Lou
    Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bldg 49, Rm 5A22, 49 Convent Drive, Bethesda, MD 20892, USA
    J Mol Neurosci 49:1-10. 2013
    ....
  2. ncbi Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes
    C Pinto-Correia
    Department of Anatomical Sciences, State University of New York, Buffalo 14214
    Dev Biol 146:301-11. 1991
    ..The results suggest that expression of the immunoreactive chromosomal adducin may be a unique feature of oogenesis...
  3. pmc Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice
    D M Gilligan
    Department of Internal Medicine Hematology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 96:10717-22. 1999
    ..This study demonstrates adducin's importance to RBC membrane stability in vivo...
  4. ncbi The mouse adducin gene family: alternative splicing and chromosomal localization
    S P Suriyapperuma
    Yale University School of Medicine, 333 Cedar Street, WWW 403, New Haven, Connecticut 06510, USA
    Mamm Genome 11:16-23. 2000
    ..We also report here the localization of the gene encoding gamma adducin (Add3) to murine Chr 19, in a region that shows conserved synteny with human Chr 10.
  5. ncbi Expression of gamma-adducin is associated with regions of morphogenetic cell movement in the chick embryo
    Jun Akai
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Mech Dev 119:S191-5. 2002
    ..Gamma-adducin is detected at particularly high levels in cell populations undergoing important morphogenetic movements, such as epiblast approaching the primitive streak, regressing spinal cord primordia and closing neural tube...
  6. ncbi Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus
    Susanne M Clee
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nat Genet 38:688-93. 2006
    ..Our identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus...
  7. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  8. pmc Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells
    Kenneth E Sahr
    The Jackson Laboratory, Bar Harbor, Maine 04606, USA
    Am J Hematol 84:354-61. 2009
    ..These results suggest that the structural properties of adducin differ significantly between erythroid and various nonerythroid cell types...
  9. doi beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits
    F Porro
    ICGEB, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Genes Brain Behav 9:84-96. 2010
    ..These results strongly suggest coordinated expression and phosphorylation of adducin subunits as a key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors...