Actc1

Summary

Gene Symbol: Actc1
Description: actin, alpha, cardiac muscle 1
Alias: Actc-1, actin, alpha cardiac muscle 1, actin alpha cardiac, alpha-cardiac actin, alphac-actin
Species: mouse

Top Publications

  1. ncbi Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus
    C B Moens
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Development 119:485-99. 1993
  2. ncbi Hop is an unusual homeobox gene that modulates cardiac development
    Fabian Chen
    Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Cell 110:713-23. 2002
  3. ncbi Modulation of cardiac growth and development by HOP, an unusual homeodomain protein
    Chong Hyun Shin
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 110:725-35. 2002
  4. ncbi A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Development 130:3877-89. 2003
  5. pmc Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin
    A Kumar
    Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 94:4406-11. 1997
  6. ncbi Characterization of the murine thrombospondin gene
    J Lawler
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Genomics 11:587-600. 1991
  7. pmc Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis
    B Robert
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    EMBO J 8:91-100. 1989
  8. ncbi Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo
    D A Sassoon
    Department of Molecular Biology, Pasteur Institute, Paris, France
    Development 104:155-64. 1988
  9. pmc The genes coding for the cardiac muscle actin, the skeletal muscle actin and the cytoplasmic beta-actin are located on three different mouse chromosomes
    H Czosnek
    EMBO J 2:1977-9. 1983
  10. ncbi FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions
    I J Mason
    Division of Anatomy and Cell Biology, U M D S Guy s Hospital, London, UK
    Mech Dev 45:15-30. 1994

Research Grants

Scientific Experts

  • T Miwa
  • Stephane D Vincent
  • Milos Galic
  • Md Shenuarin Bhuiyan
  • P M Bennett
  • P Georgiades
  • T Takeuchi
  • Christine B Kern
  • Kristen J Nowak
  • Mohamad Azhar
  • Y Saga
  • A J Roebroek
  • Eltyeb Abdelwahid
  • Anne Martin
  • Peng Li
  • Richard P Harvey
  • Ross Wilkinson
  • Weihua Song
  • Edwin P Kirk
  • Jue Zhang
  • Donna Lai
  • Sigolène M Meilhac
  • Rieko Ajima
  • Fabienne Lescroart
  • Baiyin Yuan
  • Christine B Gurniak
  • Michael D Schneider
  • Julien Ochala
  • Kristina L Bezold
  • Chinmoy Patra
  • Cristina Harmelink
  • James F Martin
  • Kuniko Nakajima
  • Fen Wang
  • Mohammad Pashmforoush
  • Margaret E Buckingham
  • Henry M Sucov
  • Jun Wang
  • Robert J Schwartz
  • Robert G Kelly
  • Xiaoli Liu
  • Seth D Berman
  • Michael P Feneley
  • Orit Wolstein
  • Diane Fatkin
  • Susan M Kiefer
  • Zhirong Yin
  • Jaya Krishnan
  • Roong Zhao
  • Manabu Shirai
  • Jane Brennan
  • Kory J Lavine
  • Dominic P Norris
  • Hideyuki Koga
  • Nesanet Mitiku
  • Kiyoko Hattori
  • Elisabeth A Gustafson-Wagner
  • Changbaig Hyun
  • M Leticia Castro
  • Jian Li
  • Kazuko Koshiba-Takeuchi
  • Adam G Diehl
  • Christina Karamboulas
  • Laura Barbosky
  • Ju Chen
  • Benoit G Bruneau
  • Zhiyv Niu
  • Xin Wang
  • Da Zhi Wang
  • Joel P Mackay
  • T Nakamura
  • Jian Hua Ding
  • Fernanda Bajanca
  • Christine Biben
  • Diego Fraidenraich
  • John Peter McPherson
  • Marguerite Lemonnier
  • Ara Parlakian
  • P S Zammit
  • M Tanaka
  • Koichiro Kuwahara
  • N A Jenkins
  • R G Kelly
  • N G Copeland
  • Lino Tessarollo
  • Natalia Smoktunowicz
  • Steven Marston
  • Margaret Buckingham
  • Xi He
  • Terry P Yamaguchi

Detail Information

Publications117 found, 100 shown here

  1. ncbi Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus
    C B Moens
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Development 119:485-99. 1993
    ..This study illustrates the importance of generating different mutations at a given locus to elucidate fully the function of a particular gene during development...
  2. ncbi Hop is an unusual homeobox gene that modulates cardiac development
    Fabian Chen
    Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Cell 110:713-23. 2002
    ..Hop encodes an unusual homeodomain protein that modulates SRF-dependent cardiac-specific gene expression and cardiac development...
  3. ncbi Modulation of cardiac growth and development by HOP, an unusual homeodomain protein
    Chong Hyun Shin
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 110:725-35. 2002
    ..We propose that HOP modulates SRF activity during heart development; its absence results in an imbalance between cardiomyocyte proliferation and differentiation with consequent abnormalities in cardiac morphogenesis...
  4. ncbi A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Development 130:3877-89. 2003
    ..We discuss how the characteristics of myocardial cell growth, which we describe, underlie the formation of the heart tube and its subsequent regionalised expansion...
  5. pmc Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin
    A Kumar
    Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 94:4406-11. 1997
    ..These results demonstrate that alterations in actin composition in the fetal and adult heart are associated with severe structural and functional perturbations...
  6. ncbi Characterization of the murine thrombospondin gene
    J Lawler
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Genomics 11:587-600. 1991
    ..The presence of various consensus sequences suggests that thrombospondin gene expression is regulated by cAMP, cytokines, and steroid hormones...
  7. pmc Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis
    B Robert
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    EMBO J 8:91-100. 1989
    ..The pronounced accumulation and regional localization of Hox-7 transcripts in mandibular and limb processes point to a specific morphogenetic role for this mouse homeobox gene...
  8. ncbi Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo
    D A Sassoon
    Department of Molecular Biology, Pasteur Institute, Paris, France
    Development 104:155-64. 1988
    ....
  9. pmc The genes coding for the cardiac muscle actin, the skeletal muscle actin and the cytoplasmic beta-actin are located on three different mouse chromosomes
    H Czosnek
    EMBO J 2:1977-9. 1983
    ..1% amino acid replacements), is located on mouse chromosome 17. The gene coding for the cytoplasmic beta-actin is located on mouse chromosome 5. Thus, these three actin genes are located on three different chromosomes...
  10. ncbi FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions
    I J Mason
    Division of Anatomy and Cell Biology, U M D S Guy s Hospital, London, UK
    Mech Dev 45:15-30. 1994
    ..Our results suggest that FGF-7 is likely to have diverse roles during development...
  11. ncbi Mice lacking factor VII develop normally but suffer fatal perinatal bleeding
    E D Rosen
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nature 390:290-4. 1997
    ..Thus, the TF-/- embryonic lethal and the FVII-/- survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation...
  12. ncbi The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
    P Riley
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Genet 18:271-5. 1998
    ..Their heart tubes showed abnormal looping and ventricular myocardial differentiation. Therefore, Hand1 is essential for differentiation of both trophoblast and cardiomyocytes, which are embryologically distinct cell lineages...
  13. ncbi Dynamic left/right regionalisation of endogenous myosin light chain 3F transcripts in the developing mouse heart
    R G Kelly
    CNRS URA 1947, Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    J Mol Cell Cardiol 30:1067-81. 1998
    ..MLC3F transgenes, however, maintain an embryonic-like distribution throughout development suggesting that myocardial gene expression is controlled by distinct temporal, as well as spatial, regulatory modules...
  14. ncbi Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability
    T Nakamura
    Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606, Japan
    Genomics 54:89-98. 1998
    ..FKBP23 mRNA is expressed most strongly in heart, lung, and testis, beginning at day 8.5 of embryonic development. The FKBP23 gene was mapped to mouse chromosome 2...
  15. ncbi Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 216:72-88. 1999
    ..Fgf9 is coexpressed with other Fgf genes in some skeletal myoblasts, in limb apical ectoderm, in craniofacial ectoderm, and in the retina, inner ear, and tooth bud. Dev Dyn 1999;216:72-88...
  16. pmc The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
    K M Lai
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5 Canada
    Genes Dev 14:1132-45. 2000
    ..ShcA may therefore orchestrate complex interactions within the vascular compartment by rendering cells permissive to respond to soluble and adhesive external cues...
  17. pmc NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    EMBO J 22:6310-21. 2003
    ..Our results indicate NRSF to be a key transcriptional regulator of the fetal cardiac gene program and suggest an important role for NRSF in maintaining normal cardiac structure and function...
  18. pmc Oriented clonal cell growth in the developing mouse myocardium underlies cardiac morphogenesis
    Sigolène M Meilhac
    Departement de Biologie du Developpement, Institut Pasteur, 28 rue de Dr Roux, 75724 Paris Cedex 15, France
    J Cell Biol 164:97-109. 2004
    ..Our results show that the myocardium, from the time of its formation, is a polarized and regionalized tissue and point to the role of oriented clonal cell growth in cardiac chamber morphogenesis...
  19. ncbi Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose
    Adam G Diehl
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor 48105, USA
    Invest Ophthalmol Vis Sci 47:1785-93. 2006
    ..PITX2 gene dose plays a central role in Axenfeld-Rieger syndrome. The purpose of this study was to test the hypothesis that the effects of Pitx2 gene dose on eye development can be molecularly dissected in available Pitx2 mutant mice...
  20. pmc The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation
    Jian Li
    Laboratory of Biology of Aging, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, 1225 Chene Bourg, Switzerland
    Mol Biol Cell 17:3978-88. 2006
    ..Our results provide first molecular evidence that the NOX family of NADPH oxidases regulate vertebrate developmental processes...
  21. doi Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis
    Zhirong Yin
    Department of Molecular Virology, Immunology, and Molecular Genetics, Ohio State University, Columbus, USA
    Circulation 117:1414-22. 2008
    ..Mouse models of this genetic defect have been unsatisfactory because homozygote null animals die early in development and heterozygotes do not exhibit a cardiac phenotype...
  22. pmc Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects
    Seth D Berman
    David H Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:14932-6. 2009
    ..The DORV is caused, at least in part, by a defect in blood vessel endothelial cells and/or heart mesenchymal cells. These findings demonstrate novel, overlapping functions for pRb and p107 in numerous murine tissues...
  23. ncbi Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo
    Stephane D Vincent
    Department of Developmental Biology, CNRS URA 2575, Institut Pasteur, Paris, France
    Mol Biol Evol 29:3181-91. 2012
    ....
  24. pmc External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane
    Milos Galic
    Department of Chemical and Systems Biology, Stanford University, 318 Campus Drive, Clark Building W200, Stanford, California 94305, USA
    Nat Cell Biol 14:874-81. 2012
    ..Together, our results show that N-BAR domains can be directly recruited to the plasma membrane by external push or internal pull forces that locally curve the plasma membrane...
  25. pmc Myocardial Mycn is essential for mouse ventricular wall morphogenesis
    Cristina Harmelink
    Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dev Biol 373:53-63. 2013
    ..In summary, Mycn acts downstream of BMP and NRG1 cardiogenic signaling pathways to promote normal myocardial wall morphogenesis...
  26. pmc A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin
    Kristina L Bezold
    University of California, Davis, California 95618, USA
    J Biol Chem 288:21496-505. 2013
    ....
  27. doi Skeletal and cardiac α-actin isoforms differently modulate myosin cross-bridge formation and myofibre force production
    Julien Ochala
    Centre of Human and Aerospace Physiological Sciences, School of Biomedical Sciences, King s College London, Room 3 3, Shepherd s House, Guy s Campus, London SE1 1UL, UK
    Hum Mol Genet 22:4398-404. 2013
    ..Taken together, the present findings provide novel primordial information about actin isoforms, their functional differences and have to be considered when designing gene therapies for ACTA1-based congenital myopathies. ..
  28. pmc Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent
    Chinmoy Patra
    Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
    Proc Natl Acad Sci U S A 110:16898-903. 2013
    ..Collectively, our analysis provides a unique example of the versatile function and signaling properties of adhesion GPCRs in vertebrates. ..
  29. doi Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance
    Christine B Gurniak
    University of Bonn, Institute of Genetics, Cell Migration Unit, Germany
    Eur J Cell Biol 93:252-66. 2014
    ..Levels of smooth muscle α-actin were increased and remained high in developing muscles, suggesting that cofilin2 plays a crucial role during the exchange of α-actin isoforms during the early postnatal remodeling of the sarcomere. ..
  30. doi A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice
    Baiyin Yuan
    MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China
    Am J Pathol 184:1967-80. 2014
    ..Taken together, these results demonstrate that AIP1-regulated actin dynamics play essential roles in heart function in mice...
  31. pmc Clonal analysis reveals a common origin between nonsomite-derived neck muscles and heart myocardium
    Fabienne Lescroart
    Unité de Génétique Moléculaire du Développement, CNRS Unité de Recherche Associée 2578, Institut Pasteur, 75015 Paris, France and
    Proc Natl Acad Sci U S A 112:1446-51. 2015
    ..By linking neck muscle and heart development, our findings highlight the importance of cardiopharyngeal mesoderm in the evolution of the vertebrate heart and neck and in the pathophysiology of human congenital disease. ..
  32. pmc A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress
    Ross Wilkinson
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Physiol Heart Circ Physiol 309:H1936-46. 2015
    ..We conclude that this leads to the observed, reduced response to β1 agonists and reduced cardiac reserve that predisposes the heart to DCM under conditions of chronic stress. ..
  33. pmc DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly
    Rieko Ajima
    Mammalian Development Laboratory, National Institute of Genetics, Mishima 411 8540, Japan
    Dev Biol 408:126-39. 2015
    ..However, deleting Daam1 further disrupted Wnt5a homozygous-null hearts, suggesting that DAAM1 also has Wnt5a-independent roles in cardiac development. ..
  34. doi Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium
    Donna Lai
    Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
    Circ Res 107:715-27. 2010
    ..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide...
  35. ncbi A developmental study of the abnormal expression of alpha-cardiac and alpha-skeletal actins in the striated muscle of a mutant mouse
    I Garner
    Delta Biotechnology Ltd, Castle Court, Nottingham, Great Britain
    Dev Biol 134:236-45. 1989
    ..These results are discussed in the context of the interaction between this actin gene pair in developing and adult striated muscle...
  36. pmc Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse
    D G Wilkinson
    Laboratory of Developmental Biochemistry, National Institute for Medical Research, Mill Hill, London, UK
    EMBO J 7:691-5. 1988
    ..The data suggest multiple roles for int-2 in development which may include migration of early mesoderm cells and induction of the otocyst...
  37. ncbi Assignment of two alpha 2 adrenoceptor subtype genes to murine chromosomes
    N C Chang
    Institute of Microbiology and Immunology, National Yang Ming Medical College, Taipei, Taiwan, ROC
    Neurosci Lett 167:105-8. 1994
    ..Both genes mapped in regions of mouse chromosomes consistent with their map location in humans. These mapping results provide additional insights into the linkage relationships among members of this important gene family...
  38. ncbi Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo
    O Delapeyriere
    Laboratoire d Oncologie Moleculaire, U 119 INSERM, Marseille, France
    Development 118:601-11. 1993
    ..In addition, recombinant FGF6 protein is able to repress the terminal differentiation of myoblasts in culture, providing additional support to the concept that FGF6 plays an important role in myogenesis...
  39. ncbi p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium
    L K Kochilas
    Division of Pediatric Cardiology, Children s Hospital of Philadelphia, Pennsylvania, USA
    Pediatr Res 45:635-42. 1999
    ..This result and further structural analysis suggests that the myocardial defect of Splotch embryos is associated with precocious cardiomyocyte differentiation...
  40. ncbi Muscle specific expression of Cre recombinase under two actin promoters in transgenic mice
    T Miwa
    Genome Information Research Center, Osaka University, Osaka, Japan
    Genesis 26:136-8. 2000
  41. ncbi Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 128:1019-31. 2001
    ..However, cardiac neural crest cells cannot be properly rescued in Raldh2(-/- )embryos, leading to outflow tract septation defects...
  42. ncbi The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
    Dominic P Norris
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
    Development 129:3455-68. 2002
    ..The feedback loop is thus essential for maintenance of Nodal signals that selectively regulate target gene expression in a temporally and spatially controlled fashion in the mouse embryo...
  43. ncbi Cellular disorganization and extensive apoptosis in the developing heart of mice that lack cardiac muscle alpha-actin: apparent cause of perinatal death
    Eltyeb Abdelwahid
    Department of Pediatrics and Medicity Research Laboratories, University of Turku, Finland
    Pediatr Res 55:197-204. 2004
    ..Other actin isoforms cannot compensate for the lack of cardiac alpha-actin, and this seems to induce apoptosis in defective cardiac myocytes, which are not able to cope with the increased workload in the perinatal phase...
  44. ncbi Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart
    Marguerite Lemonnier
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 279:55651-8. 2004
    ..This site binds myocyte enhancer factor (MEF)2 factors, principally MEF2D and MEF2A in cardiocyte nuclear extracts. These results are discussed in the context of MEF2 activity and of the regulation of the alpha-cardiac actin locus...
  45. pmc FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity
    Jue Zhang
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030 3303, USA
    Circ Res 110:e29-39. 2012
    ..Although the fibroblast growth factor (FGF) signaling axis plays important roles in heart development, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood...
  46. pmc Determination of the critical residues responsible for cardiac myosin binding protein C's interactions
    Md Shenuarin Bhuiyan
    J Mol Cell Cardiol 53:838-47. 2012
    ....
  47. pmc Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway
    Xin Wang
    University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:336-45. 2005
    ..Overall, this is the first study to rigorously establish the role of MEK5 in vivo as an activator of ERK5 and as an essential regulator of cell survival that is required for normal embryonic development...
  48. pmc Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism
    Jun Wang
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, 77030, USA
    Dev Cell 19:903-12. 2010
    ..Our findings indicate that Bmp signaling directly regulates a miRNA-mediated effector mechanism that downregulates cardiac progenitor genes and enhances myocardial differentiation...
  49. doi Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway
    Kuniko Nakajima
    Mitsubishi Kagaku Institute of Life Sciences, Machida 194 8511, Japan
    Development 138:1771-82. 2011
    ..Thus, a Jmj-cyclin D1 pathway coordinately regulates proliferation and differentiation of cardiomyocytes...
  50. ncbi Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse
    L Niswander
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 114:755-68. 1992
    ..Taken together, the data suggest that individual members of the gene family are expressed sequentially in developmental pathways such as mesoderm formation and myogenesis, and play a role in specific epithelial-mesenchymal interactions...
  51. ncbi Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart
    J H Miner
    Division of Biology, California Institute of Technology, Pasadena 91125
    Development 114:853-60. 1992
    ....
  52. ncbi Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo
    M O Ott
    Department of Molecular Biology, CNRS UA 1148, Pasteur Institute, Paris, France
    Development 111:1097-107. 1991
    ..The time and place of myf-5 expression are consistent with a role in the early events of myogenic differentiation, possibly during determination of the myogenic lineage...
  53. ncbi Actin and myosin genes are transcriptionally regulated during mouse skeletal muscle development
    R D Cox
    Department of Molecular Biology, Institut Pasteur, CNRS UA 1148, Paris, France
    Dev Biol 149:228-34. 1992
    ..Notably, transcription from the MLC3F promoter is activated after that of the MLC1F promoter, which is part of the same gene. These results are discussed in the context of published RNA data...
  54. ncbi alpha-Actin proteins and gene transcripts are colocalized in embryonic mouse muscle
    G E Lyons
    Department of Molecular Biology, URA CNRS 1148, Pasteur Institute, Paris, France
    Development 111:451-4. 1991
    ..In cardiac muscle, alpha-actin transcripts and proteins are abundantly expressed as soon as a cardiac tube forms...
  55. pmc Interspecific backcross mice show sex-specific differences in allelic inheritance
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genetics 128:813-21. 1991
    ..These studies provide evidence for sex-specific differences in allelic inheritance for chromosome 2 and suggest biological explanations for this form of transmission distortion...
  56. ncbi Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis
    D Sassoon
    Department of Molecular Biology, Pasteur Institute, Paris, France
    Nature 341:303-7. 1989
    ....
  57. ncbi The cardiac actin locus (Actc-1) is not on mouse chromosome 17 but is linked to beta 2-microglobulin on chromosome 2
    J L Crosby
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:19-23. 1989
    ..Close linkage of Actc-1 and B2m in both man and mouse provides another example of a chromosomal segment that has been conserved since the divergence of the lineages leading to these two species...
  58. ncbi Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross
    B Robert
    Nature 314:181-3. 1985
    ..No linkage between these genes was observed...
  59. ncbi Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse
    O Heidmann
    Science 234:866-8. 1986
    ....
  60. ncbi The structure of a cDNA clone corresponding to mouse cardiac muscle actin mRNA
    D P Leader
    Biosci Rep 6:741-7. 1986
    ..However a comparison with the corresponding region in skeletal muscle actin mRNAs indicated that the pattern of conservation is quite different in the two striated muscle actin isoforms...
  61. ncbi A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA
    A J Minty
    Cell 30:185-92. 1982
    ..Whereas mRNA transcribed from this gene is the major actin mRNA species in adult heart, it is present in low amounts, if at all, in adult skeletal muscle...
  62. ncbi A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene
    N Chiannilkulchai
    Genethon, Evry, France
    Hum Mol Genet 4:717-25. 1995
    ..They were characterized for their sequences, physical positions within the YAC contig, and expression patterns. Among those specifically transcribed in muscle, the calpain gene is a good positional and functional candidate for LGMD2A...
  63. ncbi Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies
    W Zhang
    Department of Biochemistry, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:1388-99. 1995
    ..These results demonstrate an unanticipated regulatory relationship between myogenin and MRF4 and suggest that MRF4 influences rib outgrowth through an indirect mechanism...
  64. ncbi Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis
    M Ito
    Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033
    Dev Biol 167:317-28. 1995
    ....
  65. ncbi Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis
    P Kastner
    Laboratoire de Genetique Moleculaire des Eucaryotes, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Cell 78:987-1003. 1994
    ..Furthermore, RXR alpha/RAR double mutants exhibited several malformations not seen in single mutants. This functional convergence strongly suggests that RXR alpha/RAR heterodimers mediate retinoid signaling in vivo...
  66. ncbi The cell adhesion molecule M-cadherin is specifically expressed in developing and regenerating, but not denervated skeletal muscle
    R Moore
    Department of Experimental Pathology, UMDS, Guy s Hospital, London, UK
    Development 117:1409-20. 1993
    ..The highly specific tissue distribution and unique developmental profile distinguishes M-cadherin from other cadherins and suggests a role in cell surface events during early myogenesis...
  67. ncbi Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles
    M Ontell
    Department of Neurobiology, Anatomy and Cell Science, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Development 117:1435-44. 1993
    ..These differences indicate that there is no single coordinate pattern of expression of contractile protein genes during initial formation of the muscles of the mouse.(ABSTRACT TRUNCATED AT 400 WORDS)..
  68. ncbi Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements
    C Y Chen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Genet 19:119-30. 1996
    ..Thus the function of the cardiac actin promoter SREs appeared to provide binding sites for SRF and Nkx-2.5 to interact and elicit striated muscle specific transcription that was independent of the MyoD family...
  69. ncbi Identification of a new family of Pbx-related homeobox genes
    T Nakamura
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Oncogene 13:2235-42. 1996
    ..The identification of two additional Meis genes identifies a new family of potential Hox cofactors as well as two new potential disease genes...
  70. ncbi Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
    J L de la Pompa
    The Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 392:182-6. 1998
    ....
  71. ncbi Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin
    A J Roebroek
    Laboratory for Molecular Oncology, Experimental Genetics Group, Center for Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology VIB, Herestraat 49, B 3000 Leuven
    Development 125:4863-76. 1998
    ..Overall, the present data identify Furin as an important activator of signals responsible for ventral closure and embryonic turning...
  72. ncbi Sox4-deficiency syndrome in mice is an animal model for common trunk
    J Ya
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, and the Department of Immunology, University of Utrecht, The Netherlands
    Circ Res 83:986-94. 1998
    ....
  73. ncbi The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development
    M Tanaka
    Cardiovascular Division, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Development 126:1269-80. 1999
    ..5 null cells exert dominant interfering effects on cardiac development, and (6) there were severe defects in yolk sac angiogenesis and hematopoiesis in the Csx/Nkx2.5 null embryos...
  74. ncbi MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube
    Y Saga
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo 158, Japan
    Development 126:3437-47. 1999
    ..These results strongly suggest that MesP1 is expressed in the heart tube precursor cells and is required for mesodermal cells to depart from the primitive streak and to generate a single heart tube...
  75. ncbi jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background
    T Takeuchi
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Mech Dev 86:29-38. 1999
    ....
  76. ncbi Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Dev Biol 217:266-77. 2000
    ..These data indicate that the homeobox gene Irx4 is likely to be an important mediator of ventricular differentiation during cardiac development, which is downstream of Nkx2-5 and dHand...
  77. ncbi Suppression of atrial myosin gene expression occurs independently in the left and right ventricles of the developing mouse heart
    P S Zammit
    CNRS URA 1947, Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Dev Dyn 217:75-85. 2000
    ..dev dyn 2000;217:75-85...
  78. ncbi Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
    W C Yeh
    Amgen Institute, Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, Canada
    Immunity 12:633-42. 2000
    ..These results suggest that Casper has two distinct roles: to cooperate with FADD and caspase-8 during embryonic development and to mediate cytoprotection against death factor-induced apoptosis...
  79. ncbi Cloning of the murine Drm gene (Cktsf1b1) and characterization of its oncogene suppressible promoter
    Q Zhang
    Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA
    Cytogenet Cell Genet 89:242-51. 2000
    ..Our results indicate that the expression of Cktsf1b1, a gene associated with early development and cell transformation, is sensitive to MKK levels and may be regulated via multiple transcription factor complexes...
  80. ncbi Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation
    Lei Wei
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Development 129:1705-14. 2002
    ..These results reveal new biological functions for Rho family proteins as essential determinants of cell proliferation signals at looping and chamber maturation stages in mammalian cardiac development...
  81. ncbi Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy
    Hideyuki Koga
    Department of Developmental Biology and Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, Japan
    Lab Invest 82:375-85. 2002
    ..rae28-induced dilated cardiomyopathy may thus provide a clue for clarifying the direct role of PcG in the maintenance of cardiomyocytes...
  82. pmc The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis
    Manabu Shirai
    Department of Developmental Biology and Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Japan
    J Clin Invest 110:177-84. 2002
    ..5 expression in cardiomyocytes. Thus, our data show that a mammalian PcG gene can play a key role in organogenesis by helping to maintain the expression of a selector gene...
  83. ncbi Ca(2+) activation and tension cost in myofilaments from mouse hearts ectopically expressing enteric gamma-actin
    Anne F Martin
    Department of Physiology and Biophysics, M C 901, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Am J Physiol Heart Circ Physiol 283:H642-9. 2002
    ..Our results indicate that an exchange of cardiac alpha-actin with an actin isoform differing in only five amino acids has a significant impact on both Ca(2+) regulation of cardiac myofilaments and the cross-bridge cycling rate...
  84. pmc Nodal activity in the node governs left-right asymmetry
    Jane Brennan
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:2339-44. 2002
    ..Our findings confirm that the mouse node is instrumental in initiating left-right axis specification and identify Nodal as the key morphogen regulating this process...
  85. pmc Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart
    Jian Hua Ding
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, USA
    EMBO J 23:885-96. 2004
    ..These studies raise a new paradigm for the etiology of certain human heart diseases of genetic or environmental origin that may be triggered by dysfunction in RNA processing...
  86. pmc Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality
    Ara Parlakian
    Laboratoire de Biologie Moléculaire de la Différenciation, Universite Paris 7, 75005 Paris, France
    Mol Cell Biol 24:5281-9. 2004
    ..5, GATA4, myocardin, and the SRF target gene c-fos prior to overt maldevelopment. We conclude that SRF is crucial for cardiac differentiation and maturation, acting as a global regulator of multiple developmental genes...
  87. ncbi Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineage
    Fernanda Bajanca
    Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciencias, Universidade de Lisboa, Lisboa, Portugal
    Dev Dyn 231:402-15. 2004
    ..Furthermore, alpha4beta1 is expressed in the hypaxial dermomyotome and is maintained by early hypaxial myogenic progenitor cells colonizing the myotome...
  88. pmc Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells
    Diego Fraidenraich
    Cancer Biology and Genetics Program, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 306:247-52. 2004
    ..Thus, ES cells have the potential to reverse congenital defects through Id-dependent local and long-range effects in a mammalian embryo...
  89. ncbi Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets
    Zhiyv Niu
    Center for Cardiovascular Development, Division of Cardiovascular Sciences, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Biol Chem 280:32531-8. 2005
    ....
  90. ncbi Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
    Kazuko Koshiba-Takeuchi
    Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nat Genet 38:175-83. 2006
    ..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...
  91. pmc The transitional junction: a new functional subcellular domain at the intercalated disc
    Pauline M Bennett
    Randall Division of Cell and Molecular Biophysics, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Mol Biol Cell 17:2091-100. 2006
    ..In particular, it provides a means for sarcomeres to be added to the ends of the cells during growth. This is of particular relevance to understanding myocyte elongation in dilated cardiomyopathy...
  92. ncbi Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse
    Edwin P Kirk
    Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, Australia
    Circ Res 98:651-8. 2006
    ..Thus, multiple anatomical processes under separate genetic control contribute to risk of PFO. Our findings demonstrate the feasibility of modeling the genetic basis of common CHD using animal genetic and genomic technologies...
  93. ncbi Apoptosis in the developing mouse heart
    Laura Barbosky
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 6011, USA
    Dev Dyn 235:2592-602. 2006
    ..These findings suggest that cardiomyocyte apoptosis is an evolutionarily conserved mechanism for normal morphogenesis of the outflow tract myocardium in avian and mammalian species...
  94. ncbi Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart
    Kiyoko Hattori
    Department of Pediatrics, Graduate School of Medical Science, Kumamoto University, Japan
    Mol Genet Metab 91:285-93. 2007
    ..Our findings support calreticulin being critical for normal heart function and structure. These mice are a useful model for the study of endoplasmic reticulum proteins, such as calreticulin, in various tissues...
  95. pmc Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy
    Edwin P Kirk
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
    Am J Hum Genet 81:280-91. 2007
    ..They provide insights into how mutation of different genes in an interactive regulatory circuit lead to diverse clinical phenotypes, with implications for diagnosis, genetic screening, and patient follow-up...
  96. pmc Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects
    Elisabeth A Gustafson-Wagner
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 293:H2680-92. 2007
    ..The mXinalpha-knockout mouse line provides a novel model of cardiac hypertrophy and cardiomyopathy with conduction defects...
  97. ncbi Genomic analysis of gastrulation and organogenesis in the mouse
    Nesanet Mitiku
    Department of Genetics, Stanford University, 300 Pasteur Drive, MC 5120, Stanford, CA 94305, USA
    Dev Cell 13:897-907. 2007
    ..Drosophila homologs of these genes are also coordinately downregulated following gastrulation, suggesting that the combined function of these genes has been conserved during metazoan evolution...
  98. pmc Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice
    Roong Zhao
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    Dev Biol 317:614-9. 2008
    ..Our data support a model whereby GATA4 or GATA6 are essential for expression of the network of transcription factors that regulate the onset of cardiac myocyte gene expression during mammalian development...
  99. doi SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes
    Susan M Kiefer
    Research and Education Service Line, St Louis Veterans Administration Medical Center, U S Department of Veterans Affairs, St Louis, Missouri 63106, USA
    Hum Mutat 29:1133-40. 2008
    ..We propose a model for the pathogenesis of TBS in which truncated Sall1 protein causes derepression of Sall-responsive target genes...
  100. doi Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function
    Jaya Krishnan
    Institute of Cell Biology, Eidgenossische Technische Hochschule, Zurich, Switzerland
    Circ Res 103:1139-46. 2008
    ....
  101. pmc Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice
    Xiaoli Liu
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Circulation 119:261-8. 2009
    ..Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation...

Research Grants1

  1. MYOSIN ISOFORM FUNCTION IN VASCULAR SMOOTH MUSCLE
    Anne Martin; Fiscal Year: 2003
    ..These experiments will provide crucial information on the role of myosin isoforms in cardiovascular function in both physiological and pathological circumstances. ..