Acta2

Summary

Gene Symbol: Acta2
Description: actin, alpha 2, smooth muscle, aorta
Alias: 0610041G09Rik, Actvs, SMalphaA, a-SMA, alphaSMA, actin, aortic smooth muscle, actin, alpha, vascular smooth muscle, alpha-actin-2
Species: mouse

Top Publications

  1. ncbi Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Dev Biol 308:421-37. 2007
  2. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
  3. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
  4. doi Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin
    Simone Kutschera
    Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 31:151-9. 2011
  5. ncbi Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    Li Yuan
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Development 129:4797-806. 2002
  6. pmc The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
    Steven Suchting
    Institut National de la Sante et de la Recherche Medicale, U833, 75005 Paris, France
    Proc Natl Acad Sci U S A 104:3225-30. 2007
  7. ncbi Hedgehog signals regulate multiple aspects of gastrointestinal development
    M Ramalho-Santos
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Development 127:2763-72. 2000
  8. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
  9. pmc Tbx1 regulates proliferation and differentiation of multipotent heart progenitors
    Li Chen
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX, USA
    Circ Res 105:842-51. 2009
  10. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010

Research Grants

  1. ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    JAMES TOMASEK; Fiscal Year: 2004
  2. James J Tomasek; Fiscal Year: 2016
  3. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  4. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  5. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
  6. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  7. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  8. Synthetic smooth muscle cell-selective promoters
    BRIAN HERRING; Fiscal Year: 2006
  9. Regulaton of Cell Proliferation
    ROBERT KELM; Fiscal Year: 2006
  10. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006

Detail Information

Publications176 found, 100 shown here

  1. ncbi Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Dev Biol 308:421-37. 2007
    ....
  2. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
  3. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
    ..Furthermore, our data link, for the first time, the function of the secondary heart field to congenital heart disease...
  4. doi Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin
    Simone Kutschera
    Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 31:151-9. 2011
    ..To characterize the role of a vascular-expressed class 3 semaphorin (semaphorin 3G [Sema3G])...
  5. ncbi Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    Li Yuan
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Development 129:4797-806. 2002
    ..Arteries, veins and larger, collecting lymphatic vessels developed normally, suggesting that neuropilin 2 is selectively required for the formation of small lymphatic vessels and capillaries...
  6. pmc The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
    Steven Suchting
    Institut National de la Sante et de la Recherche Medicale, U833, 75005 Paris, France
    Proc Natl Acad Sci U S A 104:3225-30. 2007
    ..Taken together, these data reveal Dll4 as a negative regulator of vascular sprouting and vessel branching that is required for normal vascular network formation during development...
  7. ncbi Hedgehog signals regulate multiple aspects of gastrointestinal development
    M Ramalho-Santos
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Development 127:2763-72. 2000
    ..These results show that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations...
  8. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
  9. pmc Tbx1 regulates proliferation and differentiation of multipotent heart progenitors
    Li Chen
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX, USA
    Circ Res 105:842-51. 2009
    ..Loss of Tbx1 results into hypoplasia of heart regions derived from the second heart field, a population of cardiac progenitors cells (CPCs). Thus, we hypothesized that Tbx1 is an important player in the biology of CPCs...
  10. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
    ..These findings uncover an essential role for Six1 in establishing a functionally normal ureter and provide new insights into the molecular basis of urinary tract malformations in BOR patients...
  11. pmc Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity
    Qing Ma
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Dev Biol 323:98-104. 2008
    ..These results have important implications for our understanding of cardiac lineage diversification in vivo, and for the interpretation of Cre-based fate maps...
  12. doi Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4
    Xavier Caubit
    Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, Marseille, France
    Development 135:3301-10. 2008
    ....
  13. doi Developmental origin of smooth muscle cells in the descending aorta in mice
    Per Wasteson
    Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
    Development 135:1823-32. 2008
    ....
  14. pmc Midline signaling regulates kidney positioning but not nephrogenesis through Shh
    Piyush Tripathi
    Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 340:518-27. 2010
    ..These studies also provide insights into the pathogenesis of horseshoe kidneys and how congenital kidney defects can be caused by signals outside the renal primordia...
  15. pmc Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
    Alexandre Trindade
    Centro de Informatica do Instituto Superior de Agronomia CIISA, Lisbon Technical University, Lisbon, Portugal
    Blood 112:1720-9. 2008
    ..These results establish the role of Dll4 in arterial identity determination, and regulation of angiogenesis subject to dose and location...
  16. pmc Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice
    Michael Dellinger
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, AZ, USA
    Dev Biol 319:309-20. 2008
    ..Taken together, this work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling...
  17. ncbi The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature
    Bettina Wilm
    Stahlman Cardiovascular Laboratories, Department of Medicine and Program for Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 132:5317-28. 2005
    ..Our data reveal a conserved mechanism in blood vessel formation to coelomic organs, and have major implications for our understanding of vertebrate organogenesis and vascular deficiencies of the gut...
  18. ncbi Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
    S S Gerety
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Mol Cell 4:403-14. 1999
    ..These data indicate that ephrin-B2-EphB4 interactions are intrinsically required in vascular endothelial cells and are consistent with the idea that they mediate bidirectional signaling essential for angiogenesis...
  19. ncbi The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome
    Lazaros Kochilas
    Cardiovascular Division, University of Pennsylvania, Philadelphia 19104, USA
    Dev Biol 251:157-66. 2002
    ..Based on our studies, we propose that Lgdel genes are required for the expression of soluble signals that regulate neural crest cell differentiation...
  20. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
  21. ncbi Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice
    Toshiyasu Matsui
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Cell Sci 119:3513-26. 2006
    ..Therefore, our findings indicate that Sox17 and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development...
  22. doi Msx1 and Msx2 are expressed in sub-populations of vascular smooth muscle cells
    Olivier Goupille
    CNRS URA2578, Génétique Moléculaire de la Morphogenèse, Institut Pasteur, Paris, France
    Dev Dyn 237:2187-94. 2008
    ..These results suggest major functions for Msx genes in vascular mural cell formation and remodeling...
  23. pmc Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract
    Nikhil Singh
    Department of Cell and Developmental Biology, The Cardiovascular Institute, Pereleman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, USA
    Circ Res 109:1240-9. 2011
    ..Although numerous signaling pathways, including Notch, have been implicated in this process, the role of epigenetics in OFT development remains largely unexplored...
  24. ncbi Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
    B L Bader
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Cell 95:507-19. 1998
    ..These results necessitate reevaluation of the primacy of alphav integrins in many functions including vascular development, despite reports that blockade of these integrins with antibodies or peptides prevents angiogenesis...
  25. ncbi Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
    N Villa
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095 1737, USA
    Mech Dev 108:161-4. 2001
    ..These findings identify an aspect of Notch signaling that could contribute to the mechanism by which this pathway modulates vascular morphogenesis...
  26. pmc CYR61 (CCN1) is essential for placental development and vascular integrity
    Fan E Mo
    Department of Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607 7170, USA
    Mol Cell Biol 22:8709-20. 2002
    ..The genetic and molecular basis of vessel bifurcation is presently unknown, and these findings provide new insight into this aspect of angiogenesis...
  27. ncbi WAVE2 is required for directed cell migration and cardiovascular development
    Daisuke Yamazaki
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Mianato ku, Tokyo 108 8639, Japan
    Nature 424:452-6. 2003
    ..These findings indicate that WAVE2-regulated actin reorganization might be required for proper cell movement and that a lack of functional WAVE2 impairs angiogenesis in vivo...
  28. ncbi Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets
    Zhiyv Niu
    Center for Cardiovascular Development, Division of Cardiovascular Sciences, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Biol Chem 280:32531-8. 2005
    ....
  29. pmc An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation
    Frances A High
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:353-63. 2007
    ..These results provide a molecular and cellular framework for understanding the role of Notch signaling in the etiology of congenital heart disease...
  30. ncbi Tetralogy of fallot and alterations in vascular endothelial growth factor-A signaling and notch signaling in mouse embryos solely expressing the VEGF120 isoform
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Circ Res 100:842-9. 2007
    ..Defective right ventricular outflow tract development as presented provides new insight in the etiology of tetralogy of Fallot...
  31. pmc Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling
    Koji Taniguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka, Japan
    Mol Cell Biol 27:4541-50. 2007
    ..These data suggest that Spreds play an important role in lymphatic vessel development by negatively regulating VEGF-C/VEGFR-3 signaling...
  32. ncbi Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development
    P Lindahl
    Department of Medical Biochemistry and Microbiology, University of Goteborg, Sweden
    Development 124:3943-53. 1997
    ..We also propose that postnatal alveogenesis failure in PDGF-A(-/-) mice is due to a prenatal block in the distal spreading of PDGF-Ralpha+ cells along the tubular lung epithelium during the canalicular stage of lung development...
  33. ncbi Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code
    J E Pitera
    Gastroenterology Unit, Institute of Child Health, University College London, London, England
    Gastroenterology 117:1339-51. 1999
    ..We have studied the expression domains of these genes in the gut both spatially and temporally...
  34. pmc Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function
    Wendy J French
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines, Dallas, TX, USA
    Mol Cell Biol 28:5646-57. 2008
    ..Together, these data demonstrate that PDGF receptors cooperate in the yolk sac mesothelium to direct blood vessel maturation and suggest that these effects are independent of their role in VSMC development...
  35. ncbi Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent
    B Kablar
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Development 127:1627-39. 2000
    ..Taken together, these results indicate that transdifferentiation is the fate of all smooth muscle cells in the upper esophagus and is normally initiated by Myf5...
  36. ncbi Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways
    Francesca Vitelli
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 11:915-22. 2002
    ..We hypothesize that this is due to the lack of a guidance role from the pouch endoderm, which is missing in these mutants...
  37. ncbi Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  38. pmc Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
    Pipsa Saharinen
    Molecular Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN 00014, Finland
    Genes Dev 24:875-80. 2010
    ..Our results indicate that CLP24 is a novel regulator of VEGFR-2 and VEGFR-3 signaling pathways and of normal lymphatic vessel structure...
  39. ncbi Role of laminin polymerization at the epithelial mesenchymal interface in bronchial myogenesis
    Y Yang
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Development 125:2621-9. 1998
    ..These studies indicated that lung embryonic mesenchymal cells have the potential to differentiate into smooth muscle and the process is triggered by their spreading along the airway basement membrane...
  40. ncbi Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
    A A Mailleux
    UMR144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
    Mech Dev 102:81-94. 2001
    ..These results indicate for the first time that mSPROUTY2 functions as a negative regulator of embryonic lung morphogenesis and growth...
  41. ncbi Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region
    E A Lindsay
    Department of Pediatrics Cardiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 10:997-1002. 2001
    ..Our data indicate that Df1/+ embryos are able to overcome a localized arterial growth impairment and thereby reduce the penetrance of birth defects...
  42. ncbi beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
  43. pmc Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype
    Vladimir N Simirskii
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Dev Biol 306:658-68. 2007
    ..Thus, beta1-integrin is required to maintain the lens epithelial phenotype and block inappropriate activation of some aspects of the lens fiber cell differentiation program...
  44. pmc Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
    Christopher A Jones
    Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Nat Med 14:448-53. 2008
    ....
  45. doi Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant
    Julie Plante
    Laboratory of Ontogeny and Reproduction, Centre Hospitalier Universitaire de Quebec CHUQ, Pavillon CHUL, Faculty of Medicine, Laval University, Quebec, Canada
    J Steroid Biochem Mol Biol 117:139-45. 2009
    ..Taken together, our results are in concordance with the hypothesis that in mouse fetal lungs the level of androgen receptor occupancy is finely tuned by local HSD17B2 expression...
  46. ncbi Molecular analysis of smooth muscle development in the mouse
    K M McHugh
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 204:278-90. 1995
    ....
  47. ncbi SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis
    L Li
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 75235 9148, USA
    Circ Res 78:188-95. 1996
    ....
  48. ncbi Spatial and temporal pattern of smooth muscle cell differentiation during development of the vascular system in the mouse embryo
    Y Takahashi
    Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    Anat Embryol (Berl) 194:515-26. 1996
    ..5 days, when the umbilical vessels were not surrounded by smooth muscle cells. Vascular smooth muscle cells appear to arise independently from mesenchyme at multiple sites in the vascular system...
  49. pmc Serum response factor is essential for mesoderm formation during mouse embryogenesis
    S Arsenian
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    EMBO J 17:6289-99. 1998
    ..Our study identifies SRF as a new and essential regulator of mammalian mesoderm formation. We therefore suggest that in mammals Ras/MAPK signalling contributes to mesoderm induction, as is the case in amphibia...
  50. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    ..These data demonstrate a variety of new functions for WT1 and suggest a general requirement for this protein in the formation of organs derived from the intermediate mesoderm...
  51. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..Subsequent angiogenic sprouting and vessel enlargement involves PDGF-B-dependent vSMC/PC progenitor co-migration and proliferation, and/or PDGF-B-independent new induction of vSMC/PC, depending on tissue context...
  52. ncbi PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta
    R Ohlsson
    Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
    Dev Biol 212:124-36. 1999
    ..We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney...
  53. ncbi Arteriovenous malformations in mice lacking activin receptor-like kinase-1
    L D Urness
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, USA
    Nat Genet 26:328-31. 2000
    ..The early loss of anatomical, molecular and functional distinctions between arteries and veins indicates that Acvrl1 is required for developing distinct arterial and venous vascular beds...
  54. pmc Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
    H Uyttendaele
    Department of Pathology and Obstetrics Gynecology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:5643-8. 2001
    ..Expression of an activated form of Notch4 in embryonic vasculature leads to abnormal vessel structure and patterning, implicating the Notch pathway in phases of vascular development associated with vessel patterning and remodeling...
  55. ncbi Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant
    D J Henderson
    Neural Development Unit, Institute of Child Health, University College London, London UK
    Circ Res 89:6-12. 2001
    ..We suggest that the double-sided arch arises as a primary defect in the Lp mutant, unrelated to the alignment defects, perhaps reflecting a role for the (as-yet-unknown) Lp gene in maintenance/regression of the aortic arch system...
  56. pmc The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 15:2470-82. 2001
    ..We propose that the two genes interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop...
  57. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
    ..Additional insight into these and other aspects of vascular morphogenesis should be possible through use of NG2 as a mural cell marker...
  58. ncbi The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis
    J Oh
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, 606 8501, Kyoto, Japan
    Cell 107:789-800. 2001
    ..These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis...
  59. ncbi Hedgehog is required for murine yolk sac angiogenesis
    Noah Byrd
    Department of Biology, Wesleyan University, CT 06459, USA
    Development 129:361-72. 2002
    ..Our study supports a role for hedgehog signaling in yolk sac angiogenesis...
  60. ncbi Quaking is essential for blood vessel development
    Janice K Noveroske
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genesis 32:218-30. 2002
    ..Together, these results suggest that quaking plays an essential role in vascular development and that the blood vessel defects are the cause of embryonic death...
  61. pmc Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
    Christopher P Regan
    Vertex Pharmaceuticals, Department of Biology, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:9248-53. 2002
    ..Together, these data define an essential role for Erk5 in cardiovascular development. Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis...
  62. ncbi Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice
    Mercedes Costell
    Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, Spain
    Circ Res 91:158-64. 2002
    ..Thus, perlecan is involved in the control of the outflow tract mesenchymal population size, underscoring the importance of the extracellular matrix in cardiac morphogenesis...
  63. ncbi Wnt7b regulates mesenchymal proliferation and vascular development in the lung
    Weiguo Shu
    Department of Medicine and the Molecular Cardiology Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 129:4831-42. 2002
    ..These defects lead to rupture of the major vessels and hemorrhage in the lungs after birth. These results demonstrate that Wnt7b signaling is required for proper lung mesenchymal growth and vascular development...
  64. ncbi Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development
    Yoichi Miyazaki
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Kidney Int 63:835-44. 2003
    ..In the present study, we examine the effect of BMP4 on the development of metanephric and periureteral mesenchymal cells, which express the BMP type I receptor gene, Bmpr1a (Alk3)...
  65. pmc The serum response factor coactivator myocardin is required for vascular smooth muscle development
    Shijie Li
    Departments of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 100:9366-70. 2003
    ..5 and show no evidence of vascular SMC differentiation. Myocardin is the only transcription factor known to be necessary and sufficient for vascular SMC differentiation...
  66. ncbi G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
    Maria L Allende
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:3665-7. 2003
    ..The phenotype of the conditional mutant embryos mimicked the one obtained in the embryos globally deficient in S1P1. Thus, vessel coverage by VSMCs is directed by the activity of the S1P1 receptor in ECs...
  67. ncbi PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    Aaron D Gitler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 7:107-16. 2004
    ..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis...
  68. pmc Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 18:2469-73. 2004
    ..These results demonstrate that vascular remodeling in the mouse embryo is sensitive to Dll4 gene dosage and that Notch activation in endothelial cells is essential for embryonic vascular remodeling...
  69. ncbi Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development
    Daniel G M Molin
    Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9602, 2300 RC Leiden, The Netherlands
    Circ Res 95:1109-17. 2004
    ..We hypothesize that disturbed maturation of the fourth pharyngeal arch artery, and especially abrogated vascular innervation, will result in fourth arch interruptions...
  70. pmc PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    Taija Makinen
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Genes Dev 19:397-410. 2005
    ..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions...
  71. pmc Essential role for sphingosine kinases in neural and vascular development
    Kiyomi Mizugishi
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Mol Cell Biol 25:11113-21. 2005
    ..Our findings also suggest that exploitation of this potent neuronal survival pathway could lead to the development of novel therapeutic approaches for neurological diseases...
  72. pmc Tbx18 regulates the development of the ureteral mesenchyme
    Rannar Airik
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    J Clin Invest 116:663-74. 2006
    ..Our analysis also showed that the ureteral mesenchyme derives from a distinct cell population that is separated early in kidney development from that of other mesenchymal cells of the renal system...
  73. ncbi Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10
    Shurong Chang
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Cell 126:321-34. 2006
    ....
  74. ncbi Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
    Dev Biol 299:52-62. 2006
    ..Our work unravels part of the complex interactions that govern normal lung development and may be pertinent to understanding the basis of respiratory defects in Apert syndrome...
  75. ncbi DeltaNp63 plays an anti-apoptotic role in ventral bladder development
    Wei Cheng
    Department of Surgery, Hospital for Sick Children, Toronto, M5G 1X8, Canada
    Development 133:4783-92. 2006
    ..We conclude that DeltaNp63 plays a crucial anti-apoptotic role in normal bladder development...
  76. ncbi Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Nature 445:177-82. 2007
    ....
  77. ncbi Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures
    Xingqun Liang
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0613, USA
    Circ Res 100:527-35. 2007
    ..Together, our results demonstrate that Pinch1 plays an essential role in neural crest development, perhaps in part through transforming growth factor-beta signaling...
  78. ncbi Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization
    Helen M Phillips
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Circ Res 101:137-45. 2007
    ..We propose that heterozygosity for mutations in different genes in the planar cell polarity pathway may be an important mechanism for congenital heart defects and cardiomyopathy in humans...
  79. pmc Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
    Frances A High
    Department of Cell and Developmental Biology and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:1955-9. 2008
    ..Together, these results imply that the primary role of endothelial Jag1 is to potentiate the development of neighboring vascular smooth muscle...
  80. pmc The branching programme of mouse lung development
    Ross J Metzger
    Department of Biochemistry and HHMI, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nature 453:745-50. 2008
    ..We show that this hierarchical and modular programme is genetically tractable, and it is ideally suited to encoding and evolving the complex networks of the lung and other branched organs...
  81. pmc Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 118:3725-37. 2008
    ..Our studies therefore demonstrate that EC O-glycans control the separation of blood and lymphatic vessels during embryonic and postnatal development, in part by regulating podoplanin expression...
  82. pmc Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations
    Gwenola Boulday
    INSERM, UMR S, Paris, France
    Dis Model Mech 2:168-77. 2009
    ....
  83. pmc Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning
    Asa Kolterud
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Gastroenterology 137:618-28. 2009
    ..We profiled cellular Hedgehog response patterns from embryonic day 10.5 (E10.5) to adult in murine antrum, pyloric region, small intestine, and colon...
  84. pmc Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development
    Ainara Vallejo-Illarramendi
    Department of Physiology, UCSF, San Francisco, California 94158 2611, USA
    J Clin Invest 119:2218-30. 2009
    ..Our results indicate that FAK plays an essential role in cardiac outflow tract development by promoting the activation of molecules such as Crkl and Erk1/2...
  85. pmc Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
    Thomas Boettger
    Max Planck Institut für Herz und Lungenforschung, Bad Nauheim, Germany
    J Clin Invest 119:2634-47. 2009
    ..We conclude that manipulation of miR-143/145 expression may offer a new approach for influencing vascular repair and attenuating arteriosclerotic pathogenesis...
  86. pmc Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome
    Kelly Lammerts van Bueren
    Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Dev Biol 340:369-80. 2010
    ..These results suggest that Hes1 acts downstream of Tbx1 in the morphogenesis of pharyngeal-derived structures...
  87. pmc The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
    Laura L Yates
    Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 19:2251-67. 2010
    ....
  88. pmc Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
    ..Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could equally well be exploited to stimulate tissue vascularization in ischemic disease...
  89. pmc Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract
    Junhao Mao
    Department of Cancer Biology, University of Massachusetts Medical School, LRB 405, Worcester, MA 01605, USA
    Development 137:1721-9. 2010
    ..Together, these studies provide new insights into tissue interactions underlying mammalian gastrointestinal organogenesis and disease...
  90. pmc Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development
    Arjan van der Flier
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 137:2439-49. 2010
    ..These integrins on other cells, and/or other integrins on endothelial cells, might contribute to fibronectin assembly and vascular development...
  91. pmc Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
    Kinji Asahina
    Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA
    Hepatology 53:983-95. 2011
    ..On the other hand, the Wt1(+) STM and MC/SubMCs do not contribute to sinusoidal endothelial cells, Kupffer cells, and hepatoblasts...
  92. pmc Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality
    Yaoqian Pan
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, United States
    Biochem Biophys Res Commun 408:369-74. 2011
    ..5. Expression of most miRNAs examined was compromised in VSMCs of Dicer KO. Our results indicate that Dicer is required for vascular development and regulates vascular remodeling by modulating VSMC proliferation and differentiation...
  93. pmc cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development
    A Daniel Bird
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e17843. 2011
    ..Together, these results demonstrate a crucial role for Creb1 activity for the development and differentiation of the conducting and distal lung epithelium...
  94. pmc Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice
    Aubrey C Chan
    Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA
    J Clin Invest 121:1871-81. 2011
    ..These results suggest that CCM may be more effectively treated by directing therapies based on the underlying genetic mutation rather than treating the condition as a single clinical entity...
  95. doi Msx genes define a population of mural cell precursors required for head blood vessel maturation
    Miguel Lopes
    Institut Pasteur, Génétique Moléculaire de la Morphogenèse, CNRS URA 2578, Paris, France
    Development 138:3055-66. 2011
    ..Improper coverage by VSMCs secondarily leads to incomplete maturation of the endothelial layer. Our results demonstrate that both Msx1 and Msx2 are required for the recruitment of a population of neural crest-derived VSMCs...
  96. pmc DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice
    Zixuan Chen
    Department of Physiology, Campbell Clinic, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:19018-28. 2012
    ..Our results indicate that the DGCR8 gene is required for vascular development through the regulation of VSMC proliferation, apoptosis, and differentiation...
  97. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
    ..Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses...
  98. pmc Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation
    Laura Grisanti
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Invest Dermatol 133:344-53. 2013
    ....
  99. pmc Myocardin regulates BMP10 expression and is required for heart development
    Jianhe Huang
    University of Pennsylvania, Cardiovascular Institute, Department of Medicine, Philadelphia, PA 19104 5159, USA
    J Clin Invest 122:3678-91. 2012
    ..Taken together, these data identify a heretofore undescribed myocardin/BMP10 signaling pathway that regulates cardiomyocyte proliferation and apoptosis in the embryonic heart...
  100. pmc Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro
    Erika Gustafsson
    Department of Experimental Pathology, Lund University, Lund, Sweden
    PLoS ONE 8:e53715. 2013
    ..Altogether these findings suggest that perlecan supports the maintenance of brain and skin subendothelial BMs and promotes vasculo- and angiogenesis by modulating FGF-2 function...
  101. pmc BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development
    Reema B Davis
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Development 140:1272-81. 2013
    ..This study provides the first description of a factor promoting COUP-TFII expression in vascular endothelium and highlights a novel role for chromatin remodeling in venous specification...

Research Grants19

  1. ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    JAMES TOMASEK; Fiscal Year: 2004
    ..The results obtained from this project may identify a new class of potential therapeutic targets, such as MDC-L, for intervention of lymphocyte extravasation. ..
  2. James J Tomasek; Fiscal Year: 2016
    ..abstract_text> ..
  3. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  4. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  5. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..
  6. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  7. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  8. Synthetic smooth muscle cell-selective promoters
    BRIAN HERRING; Fiscal Year: 2006
    ..Together these studies will provide a comprehensive analysis of the mechanisms regulating smooth muscle cell-selective gene expression in the genitourinary tract. [unreadable] [unreadable] [unreadable]..
  9. Regulaton of Cell Proliferation
    ROBERT KELM; Fiscal Year: 2006
    ....
  10. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
    ..abstract_text> ..
  11. VEGF gene expression in central nervous system microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2007
    ..We propose that the CNS microvascular pericyte is a regulatory cell important in the vascular response to hypoxic stress and that cyclopentenone prostagladins are involved in the pericyte stress response. ..
  12. Identification of Behavioral Genes From DEL22Q11
    Elizabeth Illingworth; Fiscal Year: 2006
    ..Our preliminary data, and the unique resources available to this project, provide the first concrete opportunity to identify behavioral genes relevant to this relatively common genetic syndrome. ..
  13. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  14. TELOKIN GENE REGULATION IN SMOOTH MUSCLE
    BRIAN HERRING; Fiscal Year: 2005
    ..The function of SRFs' interaction with these proteins will be elucidated. ..
  15. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....
  16. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..
  17. Function of the 130kDa MLCK in vasculature physiology and pathophysiology
    BRIAN PAUL HERRING; Fiscal Year: 2010
    ..Together these data will provide a comprehensive analysis of the roles played by the 130kDa MLCK in the vasculature under physiological and pathophysiological conditions. ..
  18. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2003
    ..The potential role of PC cytokines will be examined. ..