Acp1

Summary

Gene Symbol: Acp1
Description: acid phosphatase 1, soluble
Alias: 4632432E04Rik, AI427468, Acp-1, LMW-PTP, Lmptp, low molecular weight phosphotyrosine protein phosphatase, LMW-PTPase, low molecular weight cytosolic acid phosphatase
Species: mouse

Top Publications

  1. doi Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP
    Gustavo V O Fernandes
    Antonio Pedro University Hospital, Fluminense Federal University, Niteroi, RJ, Brazil
    J Cell Biochem 115:1063-9. 2014
  2. pmc Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy
    Fallou Wade
    Cardiovascular Research Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 237:482-94. 2015
  3. ncbi Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2
    U Francke
    Cytogenet Cell Genet 19:57-84. 1977
  4. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
  5. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
  6. ncbi Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids
    R Schafer
    Somatic Cell Genet 6:709-17. 1980
  7. ncbi Vitamin A-enhanced cleft palate susceptibility gene maps between C4 and B144 within the H-2 complex
    M L Tyan
    West Los Angeles Veterans Affairs Medical Center, California
    Proc Soc Exp Biol Med 202:482-6. 1993
  8. ncbi Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform
    F Magherini
    Dipartimento di Scienze Biochimiche, Universita di Firenze, Florence, Italy
    FEBS Lett 437:263-6. 1998
  9. ncbi Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading
    Stefania Rigacci
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, Italy
    J Biol Chem 277:41631-6. 2002
  10. ncbi Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation
    Paola Chiarugi
    Department of Biochemical Sciences, University of Florence, 50134 Florence, Italy
    J Biol Chem 277:37331-8. 2002

Scientific Experts

  • Anna Caselli
  • Willian F Zambuzzi
  • Elisa Giannoni
  • Paola Chiarugi
  • Fallou Wade
  • Gustavo V O Fernandes
  • Carmen V Ferreira
  • Giampietro Ramponi
  • Giovanni Raugei
  • Maria Letizia Taddei
  • Dilek Colak
  • Pearl Quijada
  • Maria C Jordan
  • Abdullah Assiri
  • Muhammad Kunhi
  • Israa Zahid
  • Coralie Poizat
  • Yingge Liu
  • Salma Mahmoud Awad
  • Kenneth P Roos
  • Haruhiro Toko
  • Karim Belhaj
  • Roberto Alvarez
  • Stephanie M Stanford
  • Mark Sussman
  • Waleed Al-Habeeb
  • Nunzio Bottini
  • Falah Al-Mohanna
  • Qussay Marashly
  • Kamar Mohamed Adib Al-Haffar
  • Paolo Cirri
  • Tania Fiaschi
  • Maikel Peppelenbosch
  • Claudia L Yano
  • Maurício de Souza Leão
  • Beni Olej
  • Alexandre D M Cavagis
  • Stefania Rigacci
  • Jose Mauro Granjeiro
  • Francesca Buricchi
  • Kaushal Parikh
  • Maikel P Peppelenbosch
  • Jose M Granjeiro
  • Saravanan Yuvaraj
  • F Magherini
  • Guido Camici
  • Elisabetta Rovida
  • Persio Dello Sbarba
  • Doriana Talini
  • Andrea Berti
  • Lucia Formigli
  • Giacomo Cozzi
  • G Camici
  • G Raugei
  • E Giannoni
  • P Cirri
  • A Modesti
  • G Ramponi
  • P Paoli
  • M L Tyan
  • D B Tyan
  • R L Stallings
  • S J O'Brien
  • R Schafer
  • U Francke
  • P A Lalley
  • I Rademacher
  • J D Minna
  • W G Nash
  • W Moss
  • M J Siciliano
  • J Ivy
  • K Willecke
  • J Doehmer

Detail Information

Publications14

  1. doi Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP
    Gustavo V O Fernandes
    Antonio Pedro University Hospital, Fluminense Federal University, Niteroi, RJ, Brazil
    J Cell Biochem 115:1063-9. 2014
    ..Together, these data show that ROS modulate FAK phosphorylation by an indirect way, suggesting that a LMW-PTP/FAK supra-molecular complex is involved in transient responses during osteoblast adhesion and spreading...
  2. pmc Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy
    Fallou Wade
    Cardiovascular Research Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 237:482-94. 2015
    The low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the ACP1 gene, is a ubiquitously expressed phosphatase whose in vivo function in the heart and in cardiac diseases remains unknown...
  3. ncbi Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2
    U Francke
    Cytogenet Cell Genet 19:57-84. 1977
    ..Striking examples of norandom segregation of mouse chromosomes were observed in these hybrids with preferential retention of 15 and segregation of 11 and the Y chromosome...
  4. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed...
  5. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...
  6. ncbi Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids
    R Schafer
    Somatic Cell Genet 6:709-17. 1980
    ..The appearance of a heteropolymeric band in hybrid cells expressing mouse GOT-1 suggests that this enzyme molecule is probably composed of two subunits...
  7. ncbi Vitamin A-enhanced cleft palate susceptibility gene maps between C4 and B144 within the H-2 complex
    M L Tyan
    West Los Angeles Veterans Affairs Medical Center, California
    Proc Soc Exp Biol Med 202:482-6. 1993
    ....
  8. ncbi Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform
    F Magherini
    Dipartimento di Scienze Biochimiche, Universita di Firenze, Florence, Italy
    FEBS Lett 437:263-6. 1998
    The low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) is a 18 kDa cytosolic enzyme, involved in the negative regulation of cell proliferation...
  9. ncbi Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading
    Stefania Rigacci
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, Italy
    J Biol Chem 277:41631-6. 2002
    ..Taken together, the results reported here are in keeping with low M(r) phosphotyrosine protein phosphatase participation in FAK-mediated focal adhesion remodeling...
  10. ncbi Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation
    Paola Chiarugi
    Department of Biochemical Sciences, University of Florence, 50134 Florence, Italy
    J Biol Chem 277:37331-8. 2002
    ....
  11. ncbi Beta-catenin interacts with low-molecular-weight protein tyrosine phosphatase leading to cadherin-mediated cell-cell adhesion increase
    Maria Letizia Taddei
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, 50134 Florence, Italy
    Cancer Res 62:6489-99. 2002
    ....
  12. ncbi A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation
    Elisa Giannoni
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
    Biochem Biophys Res Commun 348:367-73. 2006
    ..The redox-dependent enhancement of Grb2 recruitment to LMW-PTP ultimately leads to an improvement of ERK activation, likely triggering a prosurvival signal against the oxidant environment...
  13. ncbi Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation
    Anna Caselli
    Department of Biochemical Sciences and Center for Research, Transfer, High Education DENOTHE, University of Florence, Florence, Italy
    Biochemistry 46:6383-92. 2007
    ..The caveolin scaffolding domain is directly involved in the observed phenomena...
  14. doi Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation
    Willian F Zambuzzi
    Department of Biochemistry, Laboratory of Bioassays and Signal Transduction, Institute of Biology, University of Campinas, Campinas, SP, Brazil
    Cell Physiol Biochem 22:497-506. 2008
    ..In this work, we examined the expression and activity of Src and low molecular weight protein tyrosine phosphatase (LMWPTP) during osteoblast differentiation and assessed the modulation of Src kinase by LMWPTP...