Ache

Summary

Gene Symbol: Ache
Description: acetylcholinesterase
Alias: acetylcholinesterase
Species: mouse

Top Publications

  1. ncbi Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla
    Stephan Oberle
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 26:1823-32. 2006
  2. ncbi Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
    D Wolpowitz
    Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
    Neuron 25:79-91. 2000
  3. pmc Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Crta Alicante Valencia Km 87, Sant Joan d Alacant E 03550, Spain
    Mol Cell Biol 28:2908-19. 2008
  4. pmc The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons
    Yasser Elshatory
    Medical Scientist Training Program, Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 28:3291-7. 2008
  5. doi Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex
    E Dere
    Institute of Physiological Psychology, Center for Biological and Medical Research, University of Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany
    Neuroscience 153:396-405. 2008
  6. ncbi Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
    M Gautam
    Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
    Cell 85:525-35. 1996
  7. pmc Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates
    M Sternfeld
    The Eric Roland Center for Neurodegenerative Diseases, Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 97:8647-52. 2000
  8. pmc Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5
    M D Wilson
    Department of Biology, Centre for Environmental Health, PO Box 3020, University of Victoria, Victoria, British Columbia V8W 3N5, Canada
    Nucleic Acids Res 29:1352-65. 2001
  9. ncbi Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity
    Eran Meshorer
    Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
    Science 295:508-12. 2002
  10. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002

Research Grants

  1. Neurology of Attention and Neglect-A Network Approach
    Marek Marsel Mesulam; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla
    Stephan Oberle
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 26:1823-32. 2006
    ..Thus, both somatic motoneurons and PSNs in the spinal cord depend on LIFRbeta signaling for their development and maintenance, although PSNs seem to be overall less affected than somatic motoneurons by LIFRbeta deprivation...
  2. ncbi Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
    D Wolpowitz
    Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
    Neuron 25:79-91. 2000
    ....
  3. pmc Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Crta Alicante Valencia Km 87, Sant Joan d Alacant E 03550, Spain
    Mol Cell Biol 28:2908-19. 2008
    ..We report here the coimmunoprecipitation of PS1 and acetylcholinesterase (AChE), an enzyme associated with amyloid plaques...
  4. pmc The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons
    Yasser Elshatory
    Medical Scientist Training Program, Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 28:3291-7. 2008
    ..Together, these results demonstrate the requirement for Isl1 in the development of restricted telencephalic cholinergic neurons and link the development of cholinergic neurons in anatomically disparate sites to Isl1 function...
  5. doi Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex
    E Dere
    Institute of Physiological Psychology, Center for Biological and Medical Research, University of Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany
    Neuroscience 153:396-405. 2008
    ..1 KO mice exhibited normal behavioral responses to an odor. We found increased levels of acetylcholine esterase (AChE) and cAMP response element-binding protein (CREB) in the striatum of Cx31.1 KO mice...
  6. ncbi Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
    M Gautam
    Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
    Cell 85:525-35. 1996
    ....
  7. pmc Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates
    M Sternfeld
    The Eric Roland Center for Neurodegenerative Diseases, Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 97:8647-52. 2000
    ..The "read-through" variant of acetylcholinesterase (AChE-R) accumulates in the mammalian brain under acute stress...
  8. pmc Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5
    M D Wilson
    Department of Biology, Centre for Environmental Health, PO Box 3020, University of Victoria, Victoria, British Columbia V8W 3N5, Canada
    Nucleic Acids Res 29:1352-65. 2001
    ..A 296 kb segment from the physical map, spanning ACHE: to Tfr2, was compared with 267 kb of human sequence...
  9. ncbi Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity
    Eran Meshorer
    Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
    Science 295:508-12. 2002
    ..long-term consequences of stress, we studied stress-induced changes in the neuritic translocation of acetylcholinesterase (AChE) splice variants. Under normal conditions, we found the synaptic AChE-S mRNA and protein in neurites...
  10. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002
    As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
  11. pmc Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
    Klara R Birikh
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 100:283-8. 2003
    ..Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein ..
  12. ncbi Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site
    Glynis Johnson
    Department of Pediatric Surgery, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa
    Neurosci Lett 337:37-40. 2003
    b>Acetylcholinesterase (EC 3.1.1.7; AChE) is known to induce neurite outgrowth and differentiation, but its ligands are as yet unknown. Laminin-1 and collagen IV were investigated as potential ligands for AChE...
  13. ncbi Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation
    I Nijholt
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Mol Psychiatry 9:174-83. 2004
    ..neurophysiological and behavioral findings attributing much of this effect to alternative splicing of the acetylcholinesterase (AChE) gene in hippocampal neurons...
  14. ncbi Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors
    Afrim H Bytyqi
    Darmstadt University of Technology, Developmental Biology and Neurogenetics, D 64287 Darmstadt, Germany
    Eur J Neurosci 20:2953-62. 2004
    ..As an alternative, we show here for an acetylcholinesterase (AChE) knockout mouse that photoreceptor degeneration follows an impaired development of the inner retina...
  15. ncbi A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family
    Antonella De Jaco
    Department of Pharmacology, University of California San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 281:9667-76. 2006
    ..Neuroligin, butyrylcholinesterase, and acetylcholinesterase are members of the alpha,beta-hydrolase fold family of proteins sharing sequence similarity and common ..
  16. ncbi Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding
    Yves Bourne
    Ingénierie des Protéines, CNRS FRE 2738, Institut Federatif de Recherche Jean Roche, Université dela Méditerranée, Faculté d eMédecine Secteur Nord, F 13916 Marseille Cedex 20, France
    J Biol Chem 281:29256-67. 2006
    Hydrolysis of acetylcholine catalyzed by acetylcholinesterase (AChE), one of the most efficient enzymes in nature, occurs at the base of a deep and narrow active center gorge...
  17. ncbi Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes
    Alexandra A Anderson
    Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, South Kensington Campus, London, UK
    J Cell Physiol 215:82-100. 2008
    b>Acetylcholinesterase (AChE) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth...
  18. doi Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy
    Glynis Johnson
    Divisions of Paediatric Surgery Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, South Africa
    FEBS J 275:5129-38. 2008
    Despite in vitro demonstrations of non-enzymatic morphogenetic functions in acetylcholinesterase (AChE), the AChE knockout phenotype is milder than might be expected, casting doubt upon the relevance of such functions in vivo...
  19. doi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
    ..inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation...
  20. ncbi Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1beta
    Laura E Paraoanu
    Technical University Darmstadt, Institute of Zoology, Department of Developmental Biology and Neurogenetics, Schnittspahnstr 3, 64287 Darmstadt, Germany
    FEBS Lett 576:161-4. 2004
    b>Acetylcholinesterase (AChE) is likely to have roles other than the hydrolysis of acetylcholine, e.g., related to developmental processes like neurite outgrowth, differentiation and adhesion...
  21. pmc Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha
    T Imaizumi-Scherrer
    Unité de Génétique de la Différenciation, URA 1149, Departement de Biologie Moleculaire, Paris, France
    J Cell Biol 134:1241-54. 1996
    ..RI alpha transcripts are distributed in muscle fibers exactly as acetylcholinesterase, showing that this RNA is localized at the neuromuscular junction...
  22. ncbi Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species
    T L Rachinsky
    Department of Pharmacology, University of California, San Diego, La Jolla 92093
    Neuron 5:317-27. 1990
    We have isolated cDNA clones encoding acetylcholinesterase from mouse muscle and brain...
  23. ncbi Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog
    N P Pringle
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Dev Biol 177:30-42. 1996
    ....
  24. ncbi Constitutive and inducible expression of megakaryocyte-specific genes in Friend erythroleukaemia cells
    A M Vannucchi
    Division of Haematology, Careggi Hospital, Florence, Italy
    Br J Haematol 99:500-8. 1997
    ..Uninduced MELC expressed detectable levels of mRNAs for acethylcholinesterase (AChE), platelet factor-4 (PF4), glycoprotein IIb (GPIIb) and von Willebrand factor (VWF), whereas the erythroid alpha- ..
  25. ncbi Transgenic acetylcholinesterase induces enlargement of murine neuromuscular junctions but leaves spinal cord synapses intact
    C Andres
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel
    Neurochem Int 32:449-56. 1998
    b>Acetylcholinesterase (AChE) produced by spinal cord motoneurons accumulates within axo-dendritic spinal cord synapses...
  26. pmc Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice
    J A Shavit
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500 USA
    Genes Dev 12:2164-74. 1998
    ..These results provide direct evidence that the small Maf transcription factors are vital participants in embryonic development and cellular differentiation...
  27. ncbi Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells
    S Finotto
    Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
    Development 126:2935-44. 1999
    ..g. GAP43, acetylcholinesterase, adhesion molecule L1) of chromaffin cells in GR-deficient and wild-type mice...
  28. ncbi Cholinesterase activity is similar in C3H/HeJ and A/J mice and does not account for their different bronchoconstrictor responsiveness
    Y Bulut
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Exp Lung Res 25:367-78. 1999
    ..We asked if administration of neostigmine (an acetylcholinesterase inhibitor) and/or succinylcholine (an agent which competes for and inhibits butyrylcholinesterase) altered ..
  29. ncbi Synaptic assembly of the brain in the absence of neurotransmitter secretion
    M Verhage
    Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands
    Science 287:864-9. 2000
    ..Thus, synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does. Neurotransmitter secretion probably functions to validate already established synaptic connections...
  30. ncbi Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia
    A Hart
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Immunity 13:167-77. 2000
    ..We map the megakaryocytic defects in 14 Jacobsen patients to a minimal region on 11q that includes the Fli-1 gene and suggest that dysmegakaryopoiesis in these patients may be caused by hemizygous loss of Fli-1...
  31. ncbi Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality
    E G Duysen
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Pharmacol Exp Ther 299:528-35. 2001
    The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 3.1.1.7) was examined in AChE knockout mice...
  32. ncbi Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem
    A Wallén A
    Ludwig Institute for Cancer Research, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Neurosci 18:649-63. 2001
    ..In conclusion, regulation of Ret by Nurr1 in midbrain DA neurons and in the DMN has implications for both embryonal development and adult physiology in which signaling by neurotrophic factors plays important roles...
  33. ncbi Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse
    Ellen G Duysen
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Brain Res Dev Brain Res 137:43-54. 2002
    b>Acetylcholinesterase (AChE, EC3.1.1.7) functions in nerve impulse transmission, and possibly as a cell adhesion factor during neurite outgrowth. These functions predicted that a mouse with zero AChE activity would be unable to live...
  34. ncbi Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase
    Jianxin Shi
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 277:43301-8. 2002
    ..active site ligands induces a conformational change in an omega loop (Omega loop), Cys(69)-Cys(96), of acetylcholinesterase. The fluorophore acrylodan, site-specifically incorporated at positions 76, 81, and 84, on the external ..
  35. ncbi Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice
    Bin Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Pharmacol Biochem Behav 74:977-86. 2003
    b>Acetylcholinesterase (AChE) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. Overstimulation of cholinergic receptors by excess acetylcholine is known to be lethal...
  36. ncbi Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice
    Veronique Bernard
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, Laboratoire d Histologie Embryologie, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, France
    Mol Cell Neurosci 23:121-33. 2003
    We have studied the consequences of the constitutive acetylcholinesterase (AChE) deficiency in knockout mice for the AChE gene on the subcellular localization of the m2 receptor (m2R) and the regulation of its intraneuronal ..
  37. ncbi Acetylcholinesterase level and molecular isoforms are altered in brain of Reelin Orleans mutant mice
    M Salud García-Ayllón
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
    J Neurochem 87:773-9. 2003
    In this study we examined changes in acetylcholinesterase (AChE) pattern in the brain of adult Reelin Orleans (RelnOrl) homozygous mutant mice...
  38. ncbi Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion
    Shelley Camp
    University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
    Chem Biol Interact 157:79-86. 2005
    ..Li, S. Camp, P. Taylor, Tissue-specific expression and alternative mRNA processing of the mammalian acetylcholinesterase gene. J. Biol. Chem. 268 (8) (1993) 5790-5797]...
  39. ncbi Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis
    Marjorie Pick
    Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood 107:3397-406. 2006
    To study the role of the stress-induced "readthrough" acetylcholinesterase splice variant, AChE-R, in thrombopoiesis, we used transgenic mice overexpressing human AChE-R (TgR)...
  40. ncbi Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice
    L Sánchez del Campo
    Dpto de Bioquímica y Biología Molecular A, Universidad de Murcia, Spain
    Chem Biol Interact 157:431-2. 2005
    We have studied the effect of muscular dystrophy by merosin deficiency on mouse thymus acetyl- (AChE) and butyrylcholinesterase (BuChE). The organ contains AChE and BuChE activities...
  41. ncbi Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells
    Naoya Asai
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Development 133:4507-16. 2006
    ..Thus, these findings indicated that cAMP-dependent modification of RET function regulates the JNK signaling responsible for proper migration of the ENCCs in the developing gut...
  42. ncbi Thymus acetylcholinesterase activity is reduced in mice with congenital muscular dystrophy
    Susana Nieto-Cerón
    Departamento de Bioquimica y Biologia Molecular A, Universidad de Murcia, 30071 Murcia, Spain
    J Mol Neurosci 30:49-50. 2006
    ..This pathology affects the properties of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of mouse skeletal muscle and nerves (Moral-Naranjo et al...
  43. ncbi Phenotype comparison of three acetylcholinesterase knockout strains
    Ellen G Duysen
    University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Mol Neurosci 30:91-2. 2006
    The phenotypes of three mouse strains that carry the acetylcholinesterase knockout (AChE KO) mutation have been compared. The AChE KO mouse was developed from embryonic stem (ES) cells, originating from a 129/Sv blastocyst...
  44. ncbi Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase
    Emmanuelle Girard
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, 91198 Gif sur Yvette Cedex, France
    J Mol Neurosci 30:99-100. 2006
    ..skeletal neuromuscular junction (NMJ), two closely related enzymes can hydrolyze acetylcholine (ACh): acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)...
  45. ncbi Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia
    C Perry
    Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Leukemia 21:1472-80. 2007
    Hematological changes induced by various stress stimuli are accompanied by replacement of the primary acetylcholinesterase (AChE) 3' splice variant acetylcholinesterase-S (AChE-S) with the myelopoietic acetylcholinesterase-R (AChE-R) ..
  46. pmc Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice
    Isabel Martinez-Pena y Valenzuela
    Department of Molecular, Cellular, and Developmental Biology, and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Biol Cell 18:2904-11. 2007
    b>Acetylcholinesterase (AChE) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses...
  47. ncbi A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus
    Ondrej Machon
    Section for Cellular and Genetic Therapy, Institute of Microbiology, Center of Molecular Biology and Neuroscience, The National Hospital, N 1349 Oslo, Norway
    Dev Biol 311:223-37. 2007
    ..This suggests that the dose of canonical Wnt signaling determines cellular fate in the developing cortex and hippocampus, and that recession of Wnt signaling acts as a morphogenetic gradient regulating neurogenesis in the cortex...
  48. ncbi Habituation, discrimination and anxiety in transgenic mice overexpressing acetylcholinesterase splice variants
    Ora Kofman
    Department of Psychology and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beersheva, Israel
    Brain Res 1185:170-8. 2007
    TgS and TgR transgenic mice overexpress different splice variants of acetylcholinesterase and serve as models for genetic disruption of the cholinergic system...
  49. pmc Abnormal retinal development in the Btrc null mouse
    Mark Baguma-Nibasheka
    Department of Anatomy and Neurobiology, Dalhousie University Faculty of Medicine, Halifax, Canada
    Dev Dyn 238:2680-7. 2009
    ..There was also a reduction in the number of retinal ganglion cells, whereas their progenitors were increased. These findings suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types...
  50. doi AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion
    Weiyuan Ye
    Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, China
    Apoptosis 15:474-87. 2010
    We recently reported that the expression of the synaptic form of acetylcholinesterase (AChE) is induced during apoptosis in various cell types in vitro...
  51. pmc Contributions of selective knockout studies to understanding cholinesterase disposition and function
    Shelley Camp
    Department Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences 0657, University of California San Diego, La Jolla, CA 92093 0657, USA
    Chem Biol Interact 187:72-7. 2010
    The complete knockout of the acetylcholinesterase gene (AChE) in the mouse yielded a surprising phenotype that could not have been predicted from deletion of the cholinesterase genes in Drosophila, that of a living, but functionally ..
  52. doi Strain and regional dependence of alternate splicing of acetylcholinesterase in the murine brain following stress or treatment with diisopropylfluorophosphate
    Uri Livneh
    Psychology Department, Ben Gurion University of the Negev and Zlotowski Center for Neuroscience, Beer Sheva, IL 84105, Israel
    Behav Brain Res 210:107-15. 2010
    Induction of the rare readthrough variant of acetylcholinesterase (AChE-R) by an acetylcholinesterase (AChE) inhibitor or by stress was tested in four mouse strains that differ in their behavioural profiles on tests of anxiety and ..
  53. doi Changes in acetylcholinesterase expression are associated with altered presenilin-1 levels
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Sant Joan d Alacant, Alicante, Spain
    Neurobiol Aging 33:627.e27-37. 2012
    ..active component of the γ-secretase complex, as an interacting protein of the amyloid-associated enzyme acetylcholinesterase (AChE). In this study, we have explored the consequences of AChE-PS1 interactions...
  54. pmc Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors
    Nathan A Mundell
    Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 363:373-87. 2012
    ....
  55. pmc Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathy
    Carmen C Garcia
    Dept of Pharmacology and Physiology, New Jersey Medical School UMDNJ, MSB I626, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    Am J Physiol Endocrinol Metab 303:E551-61. 2012
    ..to expression of the embryonic acetylcholine receptor but to reduced muscle expression of acetylcholine esterase (AChE)...
  56. pmc Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology
    Nathalie Gaborit
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 139:4007-19. 2012
    ..Our results have uncovered complex genetic interactions between Irx3 and Irx5 in embryonic cardiac development and postnatal physiology...
  57. doi Smaller quantal size and faster kinetics of single exocytotic events in chromaffin cells from the APP/PS1 mouse model of Alzheimer's disease
    Antonio M G de Diego
    Instituto Teofilo Hernando, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Biochem Biophys Res Commun 428:482-6. 2012
    ..Furthermore, acetylcholinesterase staining of adrenal medulla indicated no apparent differences in the innervation by splanchnic cholinergic ..
  58. doi Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition
    Franziska Mohr
    Department of Pharmacology, School of Pharmacy, Biocentre N260, Max von Laue Str 9, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany
    Neuropharmacology 67:37-45. 2013
    ..is at least partly involved in Alzheimer's disease (AD) pathogenesis, with cholinergic markers such as acetylcholinesterase (AChE) activity and protein levels decreasing as cognitive decline progresses...
  59. doi Neonatal lethality of neural crest cell-specific Rest knockout mice is associated with gastrointestinal distension caused by aberrations of myenteric plexus
    Hitomi Aoki
    Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Genes Cells 19:723-42. 2014
    ..mutant mice, they do not have proper gastric retention after oral dye administration and the reduction of acetylcholinesterase (AChE) activity in NCC-derived myenteric plexus in the stomach was detected...
  60. doi Acetylcholinesterase is associated with apoptosis in β cells and contributes to insulin-dependent diabetes mellitus pathogenesis
    Bao Zhang
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate Student School of Chinese Academy of Sciences, China
    Acta Biochim Biophys Sin (Shanghai) 44:207-16. 2012
    b>Acetylcholinesterase (AChE) expression is pivotal during apoptosis. Indeed, AChE inhibitors partially protect cells from apoptosis. Insulin-dependent diabetes mellitus (IDDM) is characterized in part by pancreatic β-cell apoptosis...
  61. pmc Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target
    G Shaltiel
    Edmond and Lily Safra Center of Brain Sciences, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Brain Struct Funct 218:59-72. 2013
    ..demonstrating that stress-inducible increases in microRNA-132 (miR-132) and consequent decreases in its acetylcholinesterase (AChE) target are causally involved...
  62. doi Characterisation of acetylcholinesterase release from neuronal cells
    David A Hicks
    Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    Chem Biol Interact 203:302-8. 2013
    Although acetylcholinesterase (AChE) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised...
  63. doi High-resolution gene expression atlases for adult and developing mouse brain and spinal cord
    Alex M Henry
    The Allen Institute for Brain Science, Seattle, WA 98103, USA
    Mamm Genome 23:539-49. 2012
    ..All data and tools are freely available via the Allen Brain Atlas portal (www.brain-map.org)...
  64. doi Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease
    Xuejin Zhang
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, PR China
    Int J Biochem Cell Biol 45:265-72. 2013
    ..However, the details of this pathway are poorly understood. Previous research has shown increased acetylcholinesterase expression during apoptosis in various cell types, which suggests that acetylcholinesterase has a potential ..
  65. ncbi Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalization
    C Legay
    Laboratoire de Neurobiologie, CNRS URA 295, Ecole Normale Superieure, Paris, France
    Eur J Neurosci 7:1803-9. 1995
    We studied the splicing and compartmentalization of acetylcholinesterase (AchE) mRNAs during muscle differentiation in the mouse, both in vitro and in vivo...
  66. ncbi Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse
    R Pernas-Alonso
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Neuroreport 6:597-600. 1995
    ..b>Acetylcholinesterase mRNA level instead is decreased to about 50% with respect to wild-type values in one forth of P5 and P10 ..
  67. ncbi The ubiquitous subunit of the globin enhancer-binding protein NF-E2 (Nfe2u) maps to mouse chromosome 5
    L L Peters
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 22:490-1. 1994
  68. ncbi Promoter elements of the mouse acetylcholinesterase gene. Transcriptional regulation during muscle differentiation
    A Mutero
    Department of Pharmacology, University of California, San Diego, La Jolla 92093 0636
    J Biol Chem 270:1866-72. 1995
    The increase in acetylcholinesterase expression during muscle differentiation from myoblasts to myotubes was shown previously to reflect primarily a greater stability of the messenger RNA (mRNA)...
  69. ncbi Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2
    P G Noakes
    Department of Anatomy, Washington University Medical School, St Louis, Missouri 63110
    Nature 374:258-62. 1995
    ..By generating and characterizing mice with a targeted mutation of the s-laminin gene, we show here that s-laminin regulates formation of motor nerve terminals...
  70. ncbi Promoter elements and transcriptional control of the mouse acetylcholinesterase gene
    Y Li
    Department of Pharmacology, University of California, San Diego, La Jolla 92093 0636
    J Biol Chem 268:3563-72. 1993
    The 5'-untranslated region of the mouse acetylcholinesterase gene has been characterized structurally by RNase protection, primer extension, and sequencing. Evidence has been obtained for the use of two alternative promoters in brain...
  71. pmc Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism
    C F Bartels
    Eppley Institute, University of Nebraska Medical Center, Omaha 68198 6805
    Am J Hum Genet 52:928-36. 1993
    b>Acetylcholinesterase is present in innervated tissues, where its function is to terminate nerve impulse transmission. It is also found in the red blood cell membrane, where its function is unknown...
  72. ncbi Acetylcholinesterase and nicotinic acetylcholine receptor expression diverge in muscular dysgenic mice lacking the L-type calcium channel
    Z D Luo
    Department of Pharmacology, University of California, San Diego, La Jolla, California, 92093, USA
    J Neurochem 67:111-8. 1996
    L-type Ca2+ channels play critical roles in achieving stabilization of acetylcholinesterase (AChe) mRNA during myogenesis in C2-C12 skeletal muscle cells...
  73. ncbi Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein
    K Takahara
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53706, USA
    Genomics 31:253-6. 1996
    ..These data also indicate that PCOLCE is located within a 10- to 15-cM region of conserved synteny between human chromosome 7 and mouse chromosome 5...
  74. ncbi Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice
    A Schober
    Department of Anatomy and Cell Biology III, University of Heidelberg, Germany
    J Neurosci 17:891-903. 1997
    ..for TrkA, but not the neurotrophin receptor TrkB, show an early postnatal progressive reduction of acetylcholinesterase (AChE) enzymatic activity in the adrenal medulla and in preganglionic sympathetic neurons within the ..
  75. pmc Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration
    C Andres
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91904 Israel
    Proc Natl Acad Sci U S A 94:8173-8. 1997
    To explore the possibility that overproduction of neuronal acetylcholinesterase (AChE) confers changes in both cholinergic and morphogenic intercellular interactions, we studied developmental responses to neuronal AChE overexpression in ..
  76. ncbi Novel messenger RNA and alternative promoter for murine acetylcholinesterase
    E Atanasova
    Department of Pharmacology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 274:21078-84. 1999
    A portion of the 5'-flanking region of murine acetylcholinesterase was cloned from genomic DNA by 5'-rapid amplification of genomic ends, identified in a mouse genomic library, and sequenced...
  77. ncbi Reconstructing the pathway of the tensor veli palatini motor nerve during early mouse development
    L Zhang
    Department of Oral and Maxillofacial Surgery, Shimane Medical University, Izumo, Japan
    Anat Embryol (Berl) 201:235-44. 2000
    ....
  78. ncbi The effects of some porphyrinogenic drugs on the brain cholinergic system
    Jorge Andres Rodriguez
    Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP CONICET, University of Buenos Aires, Argentine
    Cell Mol Biol (Noisy-le-grand) 48:103-10. 2002
    In central nervous system, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyse acetylcholine. Diminished cholinesterase activity is known to alter several mental and psychomotor functions...
  79. ncbi Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
    M M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Chicago, IL 60611, USA
    Neuroscience 110:627-39. 2002
    b>Acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways...
  80. ncbi Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase
    Thomas Misgeld
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 36:635-48. 2002
    ..At subsequent stages, neurotransmission delays some steps in synaptic maturation but accelerates others. Thus, neurotransmission affects synaptogenesis from early stages and coordinates rather than drives synaptic maturation...
  81. ncbi Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon
    Jan Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    Development 130:1113-22. 2003
    ..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium...
  82. ncbi Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve
    Oliver Pabst
    Department of Cell and Molecular Biology, Institute of Biochemistry and Biotechnology, Technical University of Braunschweig, 38106 Braunschweig, Germany
    Development 130:1193-202. 2003
    ..Like other Nkx genes expressed in the CNS, Nkx2.9 seems to be involved in converting positional information into cell fate decisions...
  83. pmc FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals
    Ras Trokovic
    Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
    EMBO J 22:1811-23. 2003
    ..In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border...
  84. ncbi Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop
    Jianxin Shi
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 278:30905-11. 2003
    ..confines of a deep, narrow gorge through which acetylcholine must traverse to reach the catalytic site of acetylcholinesterase has suggested the existence of transient gorge enlargements that would enhance substrate accessibility...
  85. ncbi Respiratory survival mechanisms in acetylcholinesterase knockout mouse
    Fabrice Chatonnet
    Neurobiologie Génétique et Intégrative UPR2216, Institut de Neurobiologie Alfred Fessard IFR2218, C N R S, 91198 Gif sur Yvette Cedex, France
    Eur J Neurosci 18:1419-27. 2003
    ..Inactivation of acetylcholinesterase (AChE) by organophosphates produces respiratory failure but AChE knockout mice survive to adulthood...
  86. pmc Changes in acetylcholinesterase activity and muscarinic receptor bindings in mu-opioid receptor knockout mice
    Lu Tai Tien
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4504, USA
    Brain Res Mol Brain Res 126:38-44. 2004
    ..In the present study, we investigated whether there are compensatory changes of acetylcholinesterase activity and cholinergic receptors in mice lacking mu-opioid receptor gene...
  87. ncbi GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration
    Hideki Enomoto
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 44:623-36. 2004
    ..Thus RET-independent GFRalpha1 is dispensable for organogenesis and nerve regeneration in vivo, indicating that trans-signaling and GFRalpha-dependent NCAM signaling play a minor role physiologically...
  88. pmc LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction
    Masashi Kishi
    Department of Anatomy and Neurobiology, Washington University Medical Center, St Louis, MO 63110, USA
    J Cell Biol 169:355-66. 2005
    ..Thus, a strategy designed to identify novel synaptic components led to identification of a protein required for assembly of the postsynaptic apparatus...
  89. ncbi Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice
    Apostolia Fragkouli
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Eur J Neurosci 21:2923-38. 2005
    ..Overall our experiments demonstrate that Lhx7 expression is required for the specification or differentiation of cholinergic forebrain neurons involved in the processing of spatial information...
  90. ncbi Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE
    Yves Bourne
    Architecture et Fonction des Macromolecules Biologiques, CNRS, Marseille, France
    Chem Biol Interact 157:159-65. 2005
    The peripheral anionic site on acetylcholinesterase (AChE), located at the active site gorge entry, encompasses overlapping binding sites for allosteric activators and inhibitors...
  91. ncbi Synaptic remodeling at the skeletal neuromuscular junction of acetylcholinesterase knockout mice and its physiological relevance
    Emmanuelle Girard
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, Institut de Neurobiologie Alfred Fessard, Bâtiments 32 33, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Chem Biol Interact 157:87-96. 2005
    Acute inhibition of synaptic acetylcholinesterase (AChE) is fatal to normal animals, but AChE-knockout mice (AChE-/-) expressing normal levels of butyrylcholinesterase (BChE) could live to adulthood without AChE expression...
  92. ncbi Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses
    Dan Grisaru
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Israel
    J Immunol 176:27-35. 2006
    ..In this study, we report that the stress-induced acetylcholinesterase variant, AChE-R, and its cleavable, cell-penetrating C-terminal peptide, ARP, facilitate granulocytosis...
  93. ncbi Mouse AChE binds in vivo to domain IV of laminin-1beta
    Laura E Paraoanu
    Darmstadt University of Technology, Developmental Biology and Neurogenetics, Schnittspahnstr 3, D 64287 Darmstadt, Germany
    Chem Biol Interact 157:411-3. 2005
    Functions of acetylcholinesterase (AChE) other than hydrolysis of acetylcholine, e.g. related to cell differentiation, synaptogenesis, neuronal signaling and diseases are well documented, but mechanisms supporting them are not understood...
  94. ncbi Outcome of acetylcholinesterase deficiency for neuromuscular functioning
    E Mouisel
    U 798 INSERM, Evry, France
    Neurosci Res 55:389-96. 2006
    b>Acetylcholinesterase (AChE) plays an essential role in neuromuscular transmission, therefore it is surprising that AChE knockout (KO) mice could live to the adulthood...
  95. ncbi Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties
    Ella H Sklan
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel
    Biol Psychiatry 60:741-51. 2006
    ..Here we report the contribution of alternative splicing of acetylcholinesterase (AChE) pre-mRNA to modulate these responses...
  96. ncbi Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity
    Joachim Hartmann
    Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Science Center, Amarillo, Texas 79106, USA
    J Neurochem 100:1421-9. 2007
    ..Cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic function is unclear...
  97. pmc A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis
    Madhuri Warren
    Genesis 45:51-8. 2007
    ....
  98. ncbi Impaired hippocampal plasticity and errors in cognitive performance in mice with maladaptive AChE splice site selection
    Noa Farchi
    Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel 91904
    Eur J Neurosci 25:87-98. 2007
    ..Under stress, alternative splicing changes priority from synaptic acetylcholinesterase (AChE-S) to the normally rare, soluble and monomeric AChE-R variant, which facilitates hippocampal long-..
  99. ncbi Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cells
    J E Cohen
    Department of Physiology and Zlotowski Center of Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Hippocampus 18:182-92. 2008
    ..influences both of these functions, we hypothesized that cholinergic signaling, affected by acetylcholinesterase (AChE) activity, expression level, and alternative splicing, may provide a link between these processes...
  100. pmc Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling
    Ginam Cho
    Children s Hospital of Philadelphia, ARC 516h, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 28:1565-72. 2008
    ..These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development...
  101. pmc Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility
    I Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Cell Mol Med 12:479-95. 2008
    ..A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues...

Research Grants1

  1. Neurology of Attention and Neglect-A Network Approach
    Marek Marsel Mesulam; Fiscal Year: 2008
    ..The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect. ..