Genomes and Genes
Gene Symbol: Ache
Publications120 found, 100 shown here
- Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medullaStephan Oberle
Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
J Neurosci 26:1823-32. 2006..Thus, both somatic motoneurons and PSNs in the spinal cord depend on LIFRbeta signaling for their development and maintenance, although PSNs seem to be overall less affected than somatic motoneurons by LIFRbeta deprivation...
- Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapsesD Wolpowitz
Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
Neuron 25:79-91. 2000....
- Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylationMaria Ximena Silveyra
Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Crta Alicante Valencia Km 87, Sant Joan d Alacant E 03550, Spain
Mol Cell Biol 28:2908-19. 2008..We report here the coimmunoprecipitation of PS1 and acetylcholinesterase (AChE), an enzyme associated with amyloid plaques...
- The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neuronsYasser Elshatory
Medical Scientist Training Program, Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 28:3291-7. 2008..Together, these results demonstrate the requirement for Isl1 in the development of restricted telencephalic cholinergic neurons and link the development of cholinergic neurons in anatomically disparate sites to Isl1 function...
- Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortexE Dere
Institute of Physiological Psychology, Center for Biological and Medical Research, University of Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany
Neuroscience 153:396-405. 2008..1 KO mice exhibited normal behavioral responses to an odor. We found increased levels of acetylcholine esterase (AChE) and cAMP response element-binding protein (CREB) in the striatum of Cx31.1 KO mice...
- Defective neuromuscular synaptogenesis in agrin-deficient mutant miceM Gautam
Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
Cell 85:525-35. 1996....
- Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlatesM Sternfeld
The Eric Roland Center for Neurodegenerative Diseases, Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Proc Natl Acad Sci U S A 97:8647-52. 2000..The "read-through" variant of acetylcholinesterase (AChE-R) accumulates in the mammalian brain under acute stress...
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5M D Wilson
Department of Biology, Centre for Environmental Health, PO Box 3020, University of Victoria, Victoria, British Columbia V8W 3N5, Canada
Nucleic Acids Res 29:1352-65. 2001..A 296 kb segment from the physical map, spanning ACHE: to Tfr2, was compared with 267 kb of human sequence...
- Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivityEran Meshorer
Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
Science 295:508-12. 2002..long-term consequences of stress, we studied stress-induced changes in the neuritic translocation of acetylcholinesterase (AChE) splice variants. Under normal conditions, we found the synaptic AChE-S mRNA and protein in neurites...
- PRiMA: the membrane anchor of acetylcholinesterase in the brainAnselme L Perrier
Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
Neuron 33:275-85. 2002As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
- Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behaviorKlara R Birikh
Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
Proc Natl Acad Sci U S A 100:283-8. 2003..Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein ..
- Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic siteGlynis Johnson
Department of Pediatric Surgery, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa
Neurosci Lett 337:37-40. 2003b>Acetylcholinesterase (EC 18.104.22.168; AChE) is known to induce neurite outgrowth and differentiation, but its ligands are as yet unknown. Laminin-1 and collagen IV were investigated as potential ligands for AChE...
- Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiationI Nijholt
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
Mol Psychiatry 9:174-83. 2004..neurophysiological and behavioral findings attributing much of this effect to alternative splicing of the acetylcholinesterase (AChE) gene in hippocampal neurons...
- Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptorsAfrim H Bytyqi
Darmstadt University of Technology, Developmental Biology and Neurogenetics, D 64287 Darmstadt, Germany
Eur J Neurosci 20:2953-62. 2004..As an alternative, we show here for an acetylcholinesterase (AChE) knockout mouse that photoreceptor degeneration follows an impaired development of the inner retina...
- A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein familyAntonella De Jaco
Department of Pharmacology, University of California San Diego, La Jolla, California 92093 0636, USA
J Biol Chem 281:9667-76. 2006..Neuroligin, butyrylcholinesterase, and acetylcholinesterase are members of the alpha,beta-hydrolase fold family of proteins sharing sequence similarity and common ..
- Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium bindingYves Bourne
Ingénierie des Protéines, CNRS FRE 2738, Institut Federatif de Recherche Jean Roche, Université dela Méditerranée, Faculté d eMédecine Secteur Nord, F 13916 Marseille Cedex 20, France
J Biol Chem 281:29256-67. 2006Hydrolysis of acetylcholine catalyzed by acetylcholinesterase (AChE), one of the most efficient enzymes in nature, occurs at the base of a deep and narrow active center gorge...
- Morphoregulation by acetylcholinesterase in fibroblasts and astrocytesAlexandra A Anderson
Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, South Kensington Campus, London, UK
J Cell Physiol 215:82-100. 2008b>Acetylcholinesterase (AChE) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth...
- Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancyGlynis Johnson
Divisions of Paediatric Surgery Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, South Africa
FEBS J 275:5129-38. 2008Despite in vitro demonstrations of non-enzymatic morphogenetic functions in acetylcholinesterase (AChE), the AChE knockout phenotype is milder than might be expected, casting doubt upon the relevance of such functions in vivo...
- MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesteraseIftach Shaked
Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Immunity 31:965-73. 2009..inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation...
- Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1betaLaura E Paraoanu
Technical University Darmstadt, Institute of Zoology, Department of Developmental Biology and Neurogenetics, Schnittspahnstr 3, 64287 Darmstadt, Germany
FEBS Lett 576:161-4. 2004b>Acetylcholinesterase (AChE) is likely to have roles other than the hydrolysis of acetylcholine, e.g., related to developmental processes like neurite outgrowth, differentiation and adhesion...
- Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alphaT Imaizumi-Scherrer
Unité de Génétique de la Différenciation, URA 1149, Departement de Biologie Moleculaire, Paris, France
J Cell Biol 134:1241-54. 1996..RI alpha transcripts are distributed in muscle fibers exactly as acetylcholinesterase, showing that this RNA is localized at the neuromuscular junction...
- Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA speciesT L Rachinsky
Department of Pharmacology, University of California, San Diego, La Jolla 92093
Neuron 5:317-27. 1990We have isolated cDNA clones encoding acetylcholinesterase from mouse muscle and brain...
- Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehogN P Pringle
MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
Dev Biol 177:30-42. 1996....
- Constitutive and inducible expression of megakaryocyte-specific genes in Friend erythroleukaemia cellsA M Vannucchi
Division of Haematology, Careggi Hospital, Florence, Italy
Br J Haematol 99:500-8. 1997..Uninduced MELC expressed detectable levels of mRNAs for acethylcholinesterase (AChE), platelet factor-4 (PF4), glycoprotein IIb (GPIIb) and von Willebrand factor (VWF), whereas the erythroid alpha- ..
- Transgenic acetylcholinesterase induces enlargement of murine neuromuscular junctions but leaves spinal cord synapses intactC Andres
Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel
Neurochem Int 32:449-56. 1998b>Acetylcholinesterase (AChE) produced by spinal cord motoneurons accumulates within axo-dendritic spinal cord synapses...
- Impaired megakaryopoiesis and behavioral defects in mafG-null mutant miceJ A Shavit
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500 USA
Genes Dev 12:2164-74. 1998..These results provide direct evidence that the small Maf transcription factors are vital participants in embryonic development and cellular differentiation...
- Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cellsS Finotto
Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
Development 126:2935-44. 1999..g. GAP43, acetylcholinesterase, adhesion molecule L1) of chromaffin cells in GR-deficient and wild-type mice...
- Cholinesterase activity is similar in C3H/HeJ and A/J mice and does not account for their different bronchoconstrictor responsivenessY Bulut
Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Exp Lung Res 25:367-78. 1999..We asked if administration of neostigmine (an acetylcholinesterase inhibitor) and/or succinylcholine (an agent which competes for and inhibits butyrylcholinesterase) altered ..
- Synaptic assembly of the brain in the absence of neurotransmitter secretionM Verhage
Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht Medical Centre, Utrecht, Netherlands
Science 287:864-9. 2000..Thus, synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does. Neurotransmitter secretion probably functions to validate already established synaptic connections...
- Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopeniaA Hart
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Immunity 13:167-77. 2000..We map the megakaryocytic defects in 14 Jacobsen patients to a minimal region on 11q that includes the Fli-1 gene and suggest that dysmegakaryopoiesis in these patients may be caused by hemizygous loss of Fli-1...
- Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethalityE G Duysen
Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
J Pharmacol Exp Ther 299:528-35. 2001The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 22.214.171.124) was examined in AChE knockout mice...
- Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stemA Wallén A
Ludwig Institute for Cancer Research, Karolinska Institutet, S 171 77 Stockholm, Sweden
Mol Cell Neurosci 18:649-63. 2001..In conclusion, regulation of Ret by Nurr1 in midbrain DA neurons and in the DMN has implications for both embryonal development and adult physiology in which signaling by neurotrophic factors plays important roles...
- Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouseEllen G Duysen
Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Brain Res Dev Brain Res 137:43-54. 2002b>Acetylcholinesterase (AChE, EC126.96.36.199) functions in nerve impulse transmission, and possibly as a cell adhesion factor during neurite outgrowth. These functions predicted that a mouse with zero AChE activity would be unable to live...
- Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesteraseJianxin Shi
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 277:43301-8. 2002..active site ligands induces a conformational change in an omega loop (Omega loop), Cys(69)-Cys(96), of acetylcholinesterase. The fluorophore acrylodan, site-specifically incorporated at positions 76, 81, and 84, on the external ..
- Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout miceBin Li
Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
Pharmacol Biochem Behav 74:977-86. 2003b>Acetylcholinesterase (AChE) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. Overstimulation of cholinergic receptors by excess acetylcholine is known to be lethal...
- Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient miceVeronique Bernard
Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, Laboratoire d Histologie Embryologie, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, France
Mol Cell Neurosci 23:121-33. 2003We have studied the consequences of the constitutive acetylcholinesterase (AChE) deficiency in knockout mice for the AChE gene on the subcellular localization of the m2 receptor (m2R) and the regulation of its intraneuronal ..
- Acetylcholinesterase level and molecular isoforms are altered in brain of Reelin Orleans mutant miceM Salud García-Ayllón
Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
J Neurochem 87:773-9. 2003In this study we examined changes in acetylcholinesterase (AChE) pattern in the brain of adult Reelin Orleans (RelnOrl) homozygous mutant mice...
- Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletionShelley Camp
University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
Chem Biol Interact 157:79-86. 2005..Li, S. Camp, P. Taylor, Tissue-specific expression and alternative mRNA processing of the mammalian acetylcholinesterase gene. J. Biol. Chem. 268 (8) (1993) 5790-5797]...
- Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesisMarjorie Pick
Department of Hematology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
Blood 107:3397-406. 2006To study the role of the stress-induced "readthrough" acetylcholinesterase splice variant, AChE-R, in thrombopoiesis, we used transgenic mice overexpressing human AChE-R (TgR)...
- Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy miceL Sánchez del Campo
Dpto de Bioquímica y Biología Molecular A, Universidad de Murcia, Spain
Chem Biol Interact 157:431-2. 2005We have studied the effect of muscular dystrophy by merosin deficiency on mouse thymus acetyl- (AChE) and butyrylcholinesterase (BuChE). The organ contains AChE and BuChE activities...
- Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cellsNaoya Asai
Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Development 133:4507-16. 2006..Thus, these findings indicated that cAMP-dependent modification of RET function regulates the JNK signaling responsible for proper migration of the ENCCs in the developing gut...
- Thymus acetylcholinesterase activity is reduced in mice with congenital muscular dystrophySusana Nieto-Cerón
Departamento de Bioquimica y Biologia Molecular A, Universidad de Murcia, 30071 Murcia, Spain
J Mol Neurosci 30:49-50. 2006..This pathology affects the properties of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of mouse skeletal muscle and nerves (Moral-Naranjo et al...
- Phenotype comparison of three acetylcholinesterase knockout strainsEllen G Duysen
University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
J Mol Neurosci 30:91-2. 2006The phenotypes of three mouse strains that carry the acetylcholinesterase knockout (AChE KO) mutation have been compared. The AChE KO mouse was developed from embryonic stem (ES) cells, originating from a 129/Sv blastocyst...
- Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesteraseEmmanuelle Girard
Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, 91198 Gif sur Yvette Cedex, France
J Mol Neurosci 30:99-100. 2006..skeletal neuromuscular junction (NMJ), two closely related enzymes can hydrolyze acetylcholine (ACh): acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)...
- Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopeniaC Perry
Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Leukemia 21:1472-80. 2007Hematological changes induced by various stress stimuli are accompanied by replacement of the primary acetylcholinesterase (AChE) 3' splice variant acetylcholinesterase-S (AChE-S) with the myelopoietic acetylcholinesterase-R (AChE-R) ..
- Acetylcholinesterase mobility and stability at the neuromuscular junction of living miceIsabel Martinez-Pena y Valenzuela
Department of Molecular, Cellular, and Developmental Biology, and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Mol Biol Cell 18:2904-11. 2007b>Acetylcholinesterase (AChE) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses...
- A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampusOndrej Machon
Section for Cellular and Genetic Therapy, Institute of Microbiology, Center of Molecular Biology and Neuroscience, The National Hospital, N 1349 Oslo, Norway
Dev Biol 311:223-37. 2007..This suggests that the dose of canonical Wnt signaling determines cellular fate in the developing cortex and hippocampus, and that recession of Wnt signaling acts as a morphogenetic gradient regulating neurogenesis in the cortex...
- Habituation, discrimination and anxiety in transgenic mice overexpressing acetylcholinesterase splice variantsOra Kofman
Department of Psychology and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beersheva, Israel
Brain Res 1185:170-8. 2007TgS and TgR transgenic mice overexpress different splice variants of acetylcholinesterase and serve as models for genetic disruption of the cholinergic system...
- Abnormal retinal development in the Btrc null mouseMark Baguma-Nibasheka
Department of Anatomy and Neurobiology, Dalhousie University Faculty of Medicine, Halifax, Canada
Dev Dyn 238:2680-7. 2009..There was also a reduction in the number of retinal ganglion cells, whereas their progenitors were increased. These findings suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types...
- AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusionWeiyuan Ye
Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, China
Apoptosis 15:474-87. 2010We recently reported that the expression of the synaptic form of acetylcholinesterase (AChE) is induced during apoptosis in various cell types in vitro...
- Contributions of selective knockout studies to understanding cholinesterase disposition and functionShelley Camp
Department Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences 0657, University of California San Diego, La Jolla, CA 92093 0657, USA
Chem Biol Interact 187:72-7. 2010The complete knockout of the acetylcholinesterase gene (AChE) in the mouse yielded a surprising phenotype that could not have been predicted from deletion of the cholinesterase genes in Drosophila, that of a living, but functionally ..
- Strain and regional dependence of alternate splicing of acetylcholinesterase in the murine brain following stress or treatment with diisopropylfluorophosphateUri Livneh
Psychology Department, Ben Gurion University of the Negev and Zlotowski Center for Neuroscience, Beer Sheva, IL 84105, Israel
Behav Brain Res 210:107-15. 2010Induction of the rare readthrough variant of acetylcholinesterase (AChE-R) by an acetylcholinesterase (AChE) inhibitor or by stress was tested in four mouse strains that differ in their behavioural profiles on tests of anxiety and ..
- Changes in acetylcholinesterase expression are associated with altered presenilin-1 levelsMaria Ximena Silveyra
Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Sant Joan d Alacant, Alicante, Spain
Neurobiol Aging 33:627.e27-37. 2012..active component of the γ-secretase complex, as an interacting protein of the amyloid-associated enzyme acetylcholinesterase (AChE). In this study, we have explored the consequences of AChE-PS1 interactions...
- Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitorsNathan A Mundell
Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Dev Biol 363:373-87. 2012....
- Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathyCarmen C Garcia
Dept of Pharmacology and Physiology, New Jersey Medical School UMDNJ, MSB I626, 185 South Orange Ave, Newark, NJ 07101 1709, USA
Am J Physiol Endocrinol Metab 303:E551-61. 2012..to expression of the embryonic acetylcholine receptor but to reduced muscle expression of acetylcholine esterase (AChE)...
- Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiologyNathalie Gaborit
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Development 139:4007-19. 2012..Our results have uncovered complex genetic interactions between Irx3 and Irx5 in embryonic cardiac development and postnatal physiology...
- Smaller quantal size and faster kinetics of single exocytotic events in chromaffin cells from the APP/PS1 mouse model of Alzheimer's diseaseAntonio M G de Diego
Instituto Teofilo Hernando, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
Biochem Biophys Res Commun 428:482-6. 2012..Furthermore, acetylcholinesterase staining of adrenal medulla indicated no apparent differences in the innervation by splanchnic cholinergic ..
- Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibitionFranziska Mohr
Department of Pharmacology, School of Pharmacy, Biocentre N260, Max von Laue Str 9, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany
Neuropharmacology 67:37-45. 2013..is at least partly involved in Alzheimer's disease (AD) pathogenesis, with cholinergic markers such as acetylcholinesterase (AChE) activity and protein levels decreasing as cognitive decline progresses...
- Neonatal lethality of neural crest cell-specific Rest knockout mice is associated with gastrointestinal distension caused by aberrations of myenteric plexusHitomi Aoki
Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
Genes Cells 19:723-42. 2014..mutant mice, they do not have proper gastric retention after oral dye administration and the reduction of acetylcholinesterase (AChE) activity in NCC-derived myenteric plexus in the stomach was detected...
- Acetylcholinesterase is associated with apoptosis in β cells and contributes to insulin-dependent diabetes mellitus pathogenesisBao Zhang
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate Student School of Chinese Academy of Sciences, China
Acta Biochim Biophys Sin (Shanghai) 44:207-16. 2012b>Acetylcholinesterase (AChE) expression is pivotal during apoptosis. Indeed, AChE inhibitors partially protect cells from apoptosis. Insulin-dependent diabetes mellitus (IDDM) is characterized in part by pancreatic β-cell apoptosis...
- Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase targetG Shaltiel
Edmond and Lily Safra Center of Brain Sciences, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Brain Struct Funct 218:59-72. 2013..demonstrating that stress-inducible increases in microRNA-132 (miR-132) and consequent decreases in its acetylcholinesterase (AChE) target are causally involved...
- Characterisation of acetylcholinesterase release from neuronal cellsDavid A Hicks
Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
Chem Biol Interact 203:302-8. 2013Although acetylcholinesterase (AChE) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised...
- High-resolution gene expression atlases for adult and developing mouse brain and spinal cordAlex M Henry
The Allen Institute for Brain Science, Seattle, WA 98103, USA
Mamm Genome 23:539-49. 2012..All data and tools are freely available via the Allen Brain Atlas portal (www.brain-map.org)...
- Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's diseaseXuejin Zhang
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, PR China
Int J Biochem Cell Biol 45:265-72. 2013..However, the details of this pathway are poorly understood. Previous research has shown increased acetylcholinesterase expression during apoptosis in various cell types, which suggests that acetylcholinesterase has a potential ..
- Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalizationC Legay
Laboratoire de Neurobiologie, CNRS URA 295, Ecole Normale Superieure, Paris, France
Eur J Neurosci 7:1803-9. 1995We studied the splicing and compartmentalization of acetylcholinesterase (AchE) mRNAs during muscle differentiation in the mouse, both in vitro and in vivo...
- Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouseR Pernas-Alonso
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Neuroreport 6:597-600. 1995..b>Acetylcholinesterase mRNA level instead is decreased to about 50% with respect to wild-type values in one forth of P5 and P10 ..
- The ubiquitous subunit of the globin enhancer-binding protein NF-E2 (Nfe2u) maps to mouse chromosome 5L L Peters
Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
Genomics 22:490-1. 1994
- Promoter elements of the mouse acetylcholinesterase gene. Transcriptional regulation during muscle differentiationA Mutero
Department of Pharmacology, University of California, San Diego, La Jolla 92093 0636
J Biol Chem 270:1866-72. 1995The increase in acetylcholinesterase expression during muscle differentiation from myoblasts to myotubes was shown previously to reflect primarily a greater stability of the messenger RNA (mRNA)...
- Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2P G Noakes
Department of Anatomy, Washington University Medical School, St Louis, Missouri 63110
Nature 374:258-62. 1995..By generating and characterizing mice with a targeted mutation of the s-laminin gene, we show here that s-laminin regulates formation of motor nerve terminals...
- Promoter elements and transcriptional control of the mouse acetylcholinesterase geneY Li
Department of Pharmacology, University of California, San Diego, La Jolla 92093 0636
J Biol Chem 268:3563-72. 1993The 5'-untranslated region of the mouse acetylcholinesterase gene has been characterized structurally by RNase protection, primer extension, and sequencing. Evidence has been obtained for the use of two alternative promoters in brain...
- Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphismC F Bartels
Eppley Institute, University of Nebraska Medical Center, Omaha 68198 6805
Am J Hum Genet 52:928-36. 1993b>Acetylcholinesterase is present in innervated tissues, where its function is to terminate nerve impulse transmission. It is also found in the red blood cell membrane, where its function is unknown...
- Acetylcholinesterase and nicotinic acetylcholine receptor expression diverge in muscular dysgenic mice lacking the L-type calcium channelZ D Luo
Department of Pharmacology, University of California, San Diego, La Jolla, California, 92093, USA
J Neurochem 67:111-8. 1996L-type Ca2+ channels play critical roles in achieving stabilization of acetylcholinesterase (AChe) mRNA during myogenesis in C2-C12 skeletal muscle cells...
- Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer proteinK Takahara
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53706, USA
Genomics 31:253-6. 1996..These data also indicate that PCOLCE is located within a 10- to 15-cM region of conserved synteny between human chromosome 7 and mouse chromosome 5...
- Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, miceA Schober
Department of Anatomy and Cell Biology III, University of Heidelberg, Germany
J Neurosci 17:891-903. 1997..for TrkA, but not the neurotrophin receptor TrkB, show an early postnatal progressive reduction of acetylcholinesterase (AChE) enzymatic activity in the adrenal medulla and in preganglionic sympathetic neurons within the ..
- Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deteriorationC Andres
Department of Biological Chemistry, The Hebrew University of Jerusalem, 91904 Israel
Proc Natl Acad Sci U S A 94:8173-8. 1997To explore the possibility that overproduction of neuronal acetylcholinesterase (AChE) confers changes in both cholinergic and morphogenic intercellular interactions, we studied developmental responses to neuronal AChE overexpression in ..
- Novel messenger RNA and alternative promoter for murine acetylcholinesteraseE Atanasova
Department of Pharmacology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 274:21078-84. 1999A portion of the 5'-flanking region of murine acetylcholinesterase was cloned from genomic DNA by 5'-rapid amplification of genomic ends, identified in a mouse genomic library, and sequenced...
- Reconstructing the pathway of the tensor veli palatini motor nerve during early mouse developmentL Zhang
Department of Oral and Maxillofacial Surgery, Shimane Medical University, Izumo, Japan
Anat Embryol (Berl) 201:235-44. 2000....
- The effects of some porphyrinogenic drugs on the brain cholinergic systemJorge Andres Rodriguez
Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP CONICET, University of Buenos Aires, Argentine
Cell Mol Biol (Noisy-le-grand) 48:103-10. 2002In central nervous system, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyse acetylcholine. Diminished cholinesterase activity is known to alter several mental and psychomotor functions...
- Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholineM M Mesulam
Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Chicago, IL 60611, USA
Neuroscience 110:627-39. 2002b>Acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways...
- Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferaseThomas Misgeld
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuron 36:635-48. 2002..At subsequent stages, neurotransmission delays some steps in synaptic maturation but accelerates others. Thus, neurotransmission affects synaptogenesis from early stages and coordinates rather than drives synaptic maturation...
- Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalonJan Stenman
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
Development 130:1113-22. 2003..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium...
- Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerveOliver Pabst
Department of Cell and Molecular Biology, Institute of Biochemistry and Biotechnology, Technical University of Braunschweig, 38106 Braunschweig, Germany
Development 130:1193-202. 2003..Like other Nkx genes expressed in the CNS, Nkx2.9 seems to be involved in converting positional information into cell fate decisions...
- FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signalsRas Trokovic
Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
EMBO J 22:1811-23. 2003..In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border...
- Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loopJianxin Shi
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
J Biol Chem 278:30905-11. 2003..confines of a deep, narrow gorge through which acetylcholine must traverse to reach the catalytic site of acetylcholinesterase has suggested the existence of transient gorge enlargements that would enhance substrate accessibility...
- Respiratory survival mechanisms in acetylcholinesterase knockout mouseFabrice Chatonnet
Neurobiologie Génétique et Intégrative UPR2216, Institut de Neurobiologie Alfred Fessard IFR2218, C N R S, 91198 Gif sur Yvette Cedex, France
Eur J Neurosci 18:1419-27. 2003..Inactivation of acetylcholinesterase (AChE) by organophosphates produces respiratory failure but AChE knockout mice survive to adulthood...
- Changes in acetylcholinesterase activity and muscarinic receptor bindings in mu-opioid receptor knockout miceLu Tai Tien
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4504, USA
Brain Res Mol Brain Res 126:38-44. 2004..In the present study, we investigated whether there are compensatory changes of acetylcholinesterase activity and cholinergic receptors in mice lacking mu-opioid receptor gene...
- GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regenerationHideki Enomoto
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuron 44:623-36. 2004..Thus RET-independent GFRalpha1 is dispensable for organogenesis and nerve regeneration in vivo, indicating that trans-signaling and GFRalpha-dependent NCAM signaling play a minor role physiologically...
- LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junctionMasashi Kishi
Department of Anatomy and Neurobiology, Washington University Medical Center, St Louis, MO 63110, USA
J Cell Biol 169:355-66. 2005..Thus, a strategy designed to identify novel synaptic components led to identification of a protein required for assembly of the postsynaptic apparatus...
- Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient miceApostolia Fragkouli
Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Eur J Neurosci 21:2923-38. 2005..Overall our experiments demonstrate that Lhx7 expression is required for the specification or differentiation of cholinergic forebrain neurons involved in the processing of spatial information...
- Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChEYves Bourne
Architecture et Fonction des Macromolecules Biologiques, CNRS, Marseille, France
Chem Biol Interact 157:159-65. 2005The peripheral anionic site on acetylcholinesterase (AChE), located at the active site gorge entry, encompasses overlapping binding sites for allosteric activators and inhibitors...
- Synaptic remodeling at the skeletal neuromuscular junction of acetylcholinesterase knockout mice and its physiological relevanceEmmanuelle Girard
Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, Institut de Neurobiologie Alfred Fessard, Bâtiments 32 33, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
Chem Biol Interact 157:87-96. 2005Acute inhibition of synaptic acetylcholinesterase (AChE) is fatal to normal animals, but AChE-knockout mice (AChE-/-) expressing normal levels of butyrylcholinesterase (BChE) could live to adulthood without AChE expression...
- Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responsesDan Grisaru
Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Israel
J Immunol 176:27-35. 2006..In this study, we report that the stress-induced acetylcholinesterase variant, AChE-R, and its cleavable, cell-penetrating C-terminal peptide, ARP, facilitate granulocytosis...
- Mouse AChE binds in vivo to domain IV of laminin-1betaLaura E Paraoanu
Darmstadt University of Technology, Developmental Biology and Neurogenetics, Schnittspahnstr 3, D 64287 Darmstadt, Germany
Chem Biol Interact 157:411-3. 2005Functions of acetylcholinesterase (AChE) other than hydrolysis of acetylcholine, e.g. related to cell differentiation, synaptogenesis, neuronal signaling and diseases are well documented, but mechanisms supporting them are not understood...
- Outcome of acetylcholinesterase deficiency for neuromuscular functioningE Mouisel
U 798 INSERM, Evry, France
Neurosci Res 55:389-96. 2006b>Acetylcholinesterase (AChE) plays an essential role in neuromuscular transmission, therefore it is surprising that AChE knockout (KO) mice could live to the adulthood...
- Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic propertiesElla H Sklan
Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel
Biol Psychiatry 60:741-51. 2006..Here we report the contribution of alternative splicing of acetylcholinesterase (AChE) pre-mRNA to modulate these responses...
- Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activityJoachim Hartmann
Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Science Center, Amarillo, Texas 79106, USA
J Neurochem 100:1421-9. 2007..Cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic function is unclear...
- A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesisMadhuri Warren
Genesis 45:51-8. 2007....
- Impaired hippocampal plasticity and errors in cognitive performance in mice with maladaptive AChE splice site selectionNoa Farchi
Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel 91904
Eur J Neurosci 25:87-98. 2007..Under stress, alternative splicing changes priority from synaptic acetylcholinesterase (AChE-S) to the normally rare, soluble and monomeric AChE-R variant, which facilitates hippocampal long-..
- Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cellsJ E Cohen
Department of Physiology and Zlotowski Center of Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
Hippocampus 18:182-92. 2008..influences both of these functions, we hypothesized that cholinergic signaling, affected by acetylcholinesterase (AChE) activity, expression level, and alternative splicing, may provide a link between these processes...
- Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signalingGinam Cho
Children s Hospital of Philadelphia, ARC 516h, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
Mol Cell Biol 28:1565-72. 2008..These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development...
- Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motilityI Mor
The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
J Cell Mol Med 12:479-95. 2008..A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues...
- Neurology of Attention and Neglect-A Network ApproachMarek Marsel Mesulam; Fiscal Year: 2008..The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect. ..