Abcc1

Summary

Gene Symbol: Abcc1
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Alias: Abcc1a, Abcc1b, MRP, Mdrap, Mrp1, multidrug resistance-associated protein 1, ATP-binding cassette, sub-family C (CFTR/MRP), member 1a, ATP-binding cassette, sub-family C (CFTR/MRP), member 1b, LTC4 transporter, leukotriene C(4) transporter, multiple drug resistance-associated protein
Species: mouse

Top Publications

  1. ncbi Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia
    M J Schultz
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:4059-64. 2001
  2. ncbi Identification and characterization of the canine multidrug resistance-associated protein
    Liandong Ma
    Division of Cancer Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Cancer Ther 1:1335-42. 2002
  3. ncbi Function of prokaryotic and eukaryotic ABC proteins in lipid transport
    Antje Pohl
    Humboldt University Berlin, Institute of Biology, Invalidenstr 42, D 10115 Berlin, Germany
    Biochim Biophys Acta 1733:29-52. 2005
  4. ncbi The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress
    Cornelius F H Mueller
    Emory University Division of Cardiology, Department of Medicine, and the Atlanta Veterans Administration Hospital, Georgia 30322, USA
    Circ Res 97:637-44. 2005
  5. pmc Lipopolysaccharide increases the expression of multidrug resistance-associated protein 1 (MRP1) in RAW 264.7 macrophages
    Peter S Silverstein
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Neuroimmune Pharmacol 5:516-20. 2010
  6. ncbi Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport
    K Ito
    Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 276:15616-24. 2001
  7. ncbi Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II
    Julian D Widder
    Emory University, Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 27:762-8. 2007
  8. ncbi Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier
    A Soontornmalai
    University of Zurich, Institute of Pharmacology and Toxicology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuroscience 138:159-69. 2006
  9. pmc Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
    Markus Krohn
    Department of Neurology, Neurodegeneration Research Laboratory, University of Rostock, Rostock, Germany
    J Clin Invest 121:3924-31. 2011
  10. ncbi The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice
    D R Johnson
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center and Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 61:1469-76. 2001

Research Grants

Scientific Experts

  • Antje Pohl
  • P Borst
  • Cornelius F H Mueller
  • Gayle M Gordillo
  • Toshimitsu Okamura
  • Naoki Inui
  • Evert de Jonge
  • L J Bain
  • Peter Kleemann
  • Toshikazu Kondo
  • Margaretha van der Deen
  • Peter S Silverstein
  • A Verbon
  • Aurelio Lorico
  • Markus Krohn
  • Toni Schumacher
  • Jeffrey C Sivils
  • Jens Pahnke
  • Cathleen Lange
  • Thomas Bruning
  • Jacqueline Hofrichter
  • Ina Hummel
  • J Wijnholds
  • Jean Michel Scherrmann
  • Hélène Chapy
  • Wei Liu
  • Kristin Paarmann
  • Christina Fröhlich
  • Wei Qu
  • Tara A Cartwright
  • Nicolas Tournier
  • Salvatore Cisternino
  • Parameswaran G Sreekumar
  • Adrien Molinas
  • G Rappa
  • Ayman ElAli
  • Travis Rush
  • Anne Sophie Plath
  • Jan Stenzel
  • Johannes Steffen
  • Ulrich M Becher
  • Sabine Pfister
  • Michelle J Henderson
  • Péter Mészaros
  • Hirotsugu Hasegawa
  • Karin Klappe
  • Jan Willem Kok
  • R A Finch
  • A C Sartorelli
  • Rasmus Beedholm-Ebsen
  • Alan C Sartorelli
  • Masakata Yoshioka
  • Julie Cattelotte
  • Koen van de Wetering
  • Cornelia J F De Wolf
  • Julian D Widder
  • Qiaoli Li
  • Daniela F P Leite
  • D R Johnson
  • Sebastian Calligaris
  • Claudia Jakubzick
  • Akihiko Kimura
  • Bao Jin Zhai
  • Peter R Wielinga
  • A Soontornmalai
  • Takashi Sekine
  • Jonathan M Maher
  • Noam Zelcer
  • J Konig
  • Claire Mercier
  • Bruno Saubamea
  • Francine Behar-Cohen
  • Yuji Tanaka
  • D Keppler
  • Fanchon Bourasset
  • B D Stride
  • Xavier Declèves
  • M van der Valk
  • Oliver Von Bohlen Und Halbach
  • Yosef Avchalumov
  • Alexander Bracke
  • R G Deeley
  • Hao Yu
  • Fangqiao Lv
  • Ling Qin
  • Liandong Ma
  • Yutong Wang
  • S P Cole
  • Ronald E Cannon
  • David S Miller

Detail Information

Publications76

  1. ncbi Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia
    M J Schultz
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:4059-64. 2001
    Leukotrienes (LTs) are considered important for antibacterial defense in the lung. Multidrug resistance protein 1 (mrp1) is a transmembrane protein responsible for the cellular extrusion of LTC(4)...
  2. ncbi Identification and characterization of the canine multidrug resistance-associated protein
    Liandong Ma
    Division of Cancer Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Cancer Ther 1:1335-42. 2002
    Human multidrug resistance protein 1 (MRP1) confers resistance to the Vinca alkaloids, the anthracyclines, and the epipodophyllotoxins...
  3. ncbi Function of prokaryotic and eukaryotic ABC proteins in lipid transport
    Antje Pohl
    Humboldt University Berlin, Institute of Biology, Invalidenstr 42, D 10115 Berlin, Germany
    Biochim Biophys Acta 1733:29-52. 2005
    ..In particular, further purification and reconstitution experiments with an unambiguous role of ATP hydrolysis are needed to demonstrate a clear involvement of ABC proteins in lipid transbilayer asymmetry...
  4. ncbi The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress
    Cornelius F H Mueller
    Emory University Division of Cardiology, Department of Medicine, and the Atlanta Veterans Administration Hospital, Georgia 30322, USA
    Circ Res 97:637-44. 2005
    ..We found that human endothelial cells express the multidrug resistance protein-1 (MRP1) and use this as their major exporter of GSSG...
  5. pmc Lipopolysaccharide increases the expression of multidrug resistance-associated protein 1 (MRP1) in RAW 264.7 macrophages
    Peter S Silverstein
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Neuroimmune Pharmacol 5:516-20. 2010
    Multidrug resistance-associated protein 1 (MRP-1) is a ubiquitously expressed member of the ATP-binding cassette transporter family. MRP-1 is one of the primary transporters of glutathione and glutathione conjugates...
  6. ncbi Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport
    K Ito
    Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 276:15616-24. 2001
    Multidrug resistance protein 1 (MRP1/ABCC1) belongs to the ATP-binding cassette transporter superfamily and is capable of conferring resistance to a broad range of chemotherapeutic agents and transporting structurally diverse conjugated ..
  7. ncbi Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II
    Julian D Widder
    Emory University, Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 27:762-8. 2007
    Human endothelial cells use the multidrug resistance protein-1 (MRP1) to export glutathione disulfide (GSSG). This can promotes thiol loss during states of increased glutathione oxidation...
  8. ncbi Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier
    A Soontornmalai
    University of Zurich, Institute of Pharmacology and Toxicology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuroscience 138:159-69. 2006
    ..We report that four ATP-binding cassette transporters, Mdr1, Mrp1, Mrp2 and Mrp5 can be detected in brain endothelial cells, forming three distinct layers, with Mdr1 and Mrp5 being ..
  9. pmc Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
    Markus Krohn
    Department of Neurology, Neurodegeneration Research Laboratory, University of Rostock, Rostock, Germany
    J Clin Invest 121:3924-31. 2011
    ..were further genetically modified to lack specific ABC transporters, here we have shown that the transporter ABCC1 has an important role in cerebral Aβ clearance and accumulation...
  10. ncbi The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice
    D R Johnson
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center and Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 61:1469-76. 2001
    ..agents, we have used mice genetically deficient in both the mdr1a and mdr1b genes [mdr1a/1b(-/-) mice], the mrp1 gene [mrp1(-/-) mice], and the combined genes mdr1a/1b and mrp1 [mdr1a/1b(-/-), mrp1(-/-) mice] and embryonic ..
  11. ncbi The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes
    D F Robbiani
    Department of Pathology and Immunology Program Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY 10029, USA
    Cell 103:757-68. 2000
    ..skin to lymph nodes utilizes the leukotriene C(4) (LTC(4)) transporter multidrug resistance-associated protein 1 (MRP1)...
  12. pmc Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
    J Wijnholds
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Clin Invest 105:279-85. 2000
    Multidrug resistance protein 1 (MRP1) is a transporter protein that helps to protect normal cells and tumor cells against the influx of certain xenobiotics...
  13. ncbi Different pattern of MRP localization in ciliated and basal cells from human bronchial epithelium
    J M Brechot
    Laboratoire d Histologie Biologie Tumorale, Universite Pierre et Marie Curie Paris VI, Hopital Tenon, Paris, France
    J Histochem Cytochem 46:513-7. 1998
    The MRP (multidrug resistance-associated protein) transmembrane transporter, which actively transports a wide variety of lipophilic substrates out of cancer cells, has been suggested to play a major role in cell detoxification via efflux ..
  14. ncbi Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
    A Lorico
    Department of Pharmacology, Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 57:5238-42. 1997
    The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in vivo...
  15. ncbi Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter
    B D Stride
    Cancer Research Laboratories, Queen s University, Kingston, Canada
    Mol Pharmacol 49:962-71. 1996
    In vitro, overexpression of the human multidrug-resistance protein (MRP) causes a form of multidrug resistance similar to that conferred by P-glycoprotein, although the two proteins are only very distantly related...
  16. ncbi Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
    J Wijnholds
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    Nat Med 3:1275-9. 1997
    The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many drugs, glutathione S-conjugates (GS-X) of lipophilic xenobiotics and endogenous cysteinyl leukotrienes...
  17. pmc Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis
    A Verbon
    Department of Infectious Diseases, Tropical Medicine and AIDS, Laboratory of Experimental Internal Medicine and Department of Pathology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Immunol 130:32-6. 2002
    ..To determine the role of Mrp1 in the pathogenesis of tuberculosis, Mrp1 deficient (-/-) and normal wild type mice were intranasally infected with ..
  18. pmc Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers
    Tara A Cartwright
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Cereb Blood Flow Metab 33:381-8. 2013
    ..and blood-spinal cord barriers and, importantly, identifies multidrug resistance-associated protein 1 (Mrp1, Abcc1) as the transporter that mediates S1P efflux from brain and spinal cord endothelial cells...
  19. pmc Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells
    Gayle M Gordillo
    From the Department of Plastic Surgery, Davis Heart and Lung Research Institute, and
    J Biol Chem 291:10089-103. 2016
    ..Multidrug resistance-associated protein-1 (MRP-1), an active GSSG efflux mechanism, showed 2-fold increased activity in EOMA compared with MAE cells...
  20. pmc Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier
    Hélène Chapy
    Variabilité de réponse aux psychotropes, INSERM, U1144, Paris, France
    Br J Pharmacol 173:497-510. 2016
    The respective impact and interplay between ABC (P-glycoprotein/P-gp/Abcb1a, BCRP/ABCG2, MRP/ABCC) and SLC transporter functions at the blood-brain barrier (BBB) and blood-retinal barriers (BRB) are incompletely understood.
  21. pmc Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception
    Noam Zelcer
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:7274-9. 2005
    ..The pharamacokinetics of injected morphine-glucuronides are altered as well in the absence of Mrp3, and this results in a decreased antinociceptive potency of injected morphine-6-glucuronide...
  22. doi Accumulation of murine amyloid-β mimics early Alzheimer's disease
    Markus Krohn
    1 Translational Neurodegeneration Research and Neuropathology Lab, Department of Neuro Pathology, University of Oslo UiO and Oslo University Hospital OUS, Oslo, Norway 2 Department of Neurology, University of Rostock, Rostock, Germany
    Brain 138:2370-82. 2015
    ..double-deficient for neprilysin (encoded by Mme), one major amyloid-β-degrading enzyme, and the ABC transporter ABCC1, a major contributor to amyloid-β clearance from the brain, develop various aspects of sporadic Alzheimer's ..
  23. doi Apolipoprotein A-I and adenosine triphosphate-binding cassette transporter A1 expression alleviates lipid accumulation in hepatocytes
    Wei Liu
    Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, School of Basic Medical Sciences, Capital Medical University, Beijing, China
    J Gastroenterol Hepatol 29:614-22. 2014
    ..Here, we examined the effect of apoA-I or ABCA1 overexpression on hepatic lipid levels in BEL-7402 cells...
  24. doi Imaging of activity of multidrug resistance-associated protein 1 in the lungs
    Toshimitsu Okamura
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Am J Respir Cell Mol Biol 49:335-40. 2013
    Multidrug resistance-associated protein 1 (MRP1) transports various xenobiotics and metabolites across cell membranes, and the alteration of MRP1 expression is associated with certain lung diseases...
  25. pmc Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium
    Adrien Molinas
    Equipe Neurophysiologie de la Peripherie des Systèmes Chimiosensoriels, Centre des Sciences du Gout et de l Alimentation, CNRS UMR 6265, INRA, Universite de Bourgogne, Dijon, France
    PLoS ONE 7:e36167. 2012
    P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP1) are membrane transporter proteins which function as efflux pumps at cell membranes and are considered to exert a protective function against the entry of xenobiotics...
  26. doi Expression and function of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells from aging mice
    Naoki Inui
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Gerontol A Biol Sci Med Sci 67:1049-55. 2012
    ..05). These data showed that LDCs from aged mice exhibited multidrug resistance protein 1- and multidrug resistance-associated protein 1-mediated efflux and that the age-associated changes differed according to transporters...
  27. pmc LOSS of Mrp1 alters detoxification enzyme expression in a tissue- and hormonal-status-specific manner
    Jeffrey C Sivils
    Department of Biological Sciences, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79910, USA
    J Appl Toxicol 33:766-73. 2013
    The multidrug resistance-associated protein1 (MRP1/ABCC1) is a member of the ABCC transporter subfamily that mediates the efflux of pharmaceuticals, xenobiotics and steroid hormones, typically as glutathione, glucuronide or sulfate ..
  28. pmc Metallothionein blocks oxidative DNA damage in vitro
    Wei Qu
    Inorganic Toxicology Group, National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 87:311-21. 2013
    ..Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in MT-null cells...
  29. pmc Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux
    Parameswaran G Sreekumar
    Arnold and Mabel Beckman Macular Research Center, Doheny Eye Institute, Los Angeles, California, United States of America
    PLoS ONE 7:e33420. 2012
    ..Multiple multidrug resistance protein (MRP) family isoforms were expressed in RPE, among which MRP1 was the most abundant...
  30. pmc ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice
    Toni Schumacher
    Neurodegeneration Research Laboratory NRL, Department of Neurology, Universities of Rostock and Magdeburg, Magdeburg, Germany
    PLoS ONE 7:e35613. 2012
    ..Therefore, we sought to determine brain-related phenotypic changes in animals lacking the expression of distinct ABC transporters (ABCB1, ABCG2 or ABCC1).
  31. doi Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1
    Travis Rush
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53233, USA
    Neurotoxicology 33:476-81. 2012
    ..Inhibition of multidrug resistance protein-1 (MRP1) potentiated MeHg neurotoxicity and increased cellular MeHg...
  32. doi Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication
    Ayman ElAli
    Department of Neurology, University Hospital Essen, Hufelandstr 55, D 45122 Essen, Germany
    Stroke 43:1647-53. 2012
    ....
  33. ncbi Multidrug resistance associated protein 1 protects against bilirubin-induced cytotoxicity
    Sebastian Calligaris
    Centro Studi Fegato, Bld Q, Area Science Park, Basovizza Campus, SS 14 Km 163 5, 34012 Trieste, Italy
    FEBS Lett 580:1355-9. 2006
    We have shown that multidrug resistance associated protein 1 (MRP1) mediates ATP-dependent extrusion of bilirubin, possibly limiting its potentially toxic accumulation in cells...
  34. doi Expressions of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells
    Hirotsugu Hasegawa
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Life Sci 89:282-7. 2011
    Multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 1 (MRP1) are ATP-binding cassette transporters that mediate the efflux of a broad spectrum of substances and xenobiotics from cells in barrier organs...
  35. pmc Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
    Margaretha van der Deen
    Pulmonology Department, University Medical Center Groningen and University of Groningen, The Netherlands
    Respir Res 8:49. 2007
    ..The ABC transporters multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp/MDR1) extrude a wide variety of toxic substances across cellular membranes and are highly ..
  36. ncbi Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process
    Qiaoli Li
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Exp Dermatol 16:853-9. 2007
    ..Analysis of the transcript levels of Abcc1-10 and 12 in the liver of Abcc6 (-/-) mice by quantitative RT-PCR indicated that the levels of other C family ..
  37. doi Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Circulation 117:2912-8. 2008
    We recently showed that the multidrug resistance related protein-1 (MRP1) is important for the management of oxidative stress in vascular cells. However, the underlying mechanism and the in vivo relevance of these findings remain elusive...
  38. doi Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation
    Masakata Yoshioka
    Dept of Respiratory Medicine, Juntendo Univ School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Physiol Lung Cell Mol Physiol 296:L30-6. 2009
    Multidrug resistance-associated protein 1 (MRP1) is a cysteinyl leukotriene (CysLT) export pump expressed on mast cells. CysLTs are crucial mediators in allergic airway disease...
  39. doi Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2
    Julie Cattelotte
    INSERM U705, CNRS UMR 7157, Universite Paris Descartes, Universite Paris Diderot, Paris, France
    J Neurochem 108:767-75. 2009
    ..determine the influence of BBB features like the ATP-binding cassette transporters (Abcb1/P-glycoprotein (P-gp), Abcc1/Mrp1, and Abcg2/Bcrp), organic cation transporters (Slc22a1-3/Oct1-3), the transmembrane potential and the dipole ..
  40. doi Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Innere Medizin, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Mol Cell Biochem 333:261-7. 2010
    The multidrug resistance-related protein-1 (MRP1) is important for the management of oxidative stress in vascular cells in vivo...
  41. pmc ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux
    Michelle J Henderson
    Experimental Therapeutics and Molecular Diagnostics Program, Children s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, P O Box 81, Randwick, NSW 2031, Australia
    J Natl Cancer Inst 103:1236-51. 2011
    ....
  42. doi Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin
    Rasmus Beedholm-Ebsen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 115:1632-9. 2010
    ..cellular gene silencing showed a role in cellular Cbl efflux of the ATP-binding cassette (ABC)-drug transporter, ABCC1, alias multidrug resistance protein 1 (MRP1), which is present in the basolateral membrane of intestinal ..
  43. pmc Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes
    Jeffrey C Sivils
    Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA
    Gen Comp Endocrinol 167:51-9. 2010
    The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (..
  44. doi Multidrug resistance-related protein 1 (MRP1) function and localization depend on cortical actin
    Ina Hummel
    University Medical Center Groningen, University of Groningen, Department of Cell Biology, Section Membrane Cell Biology, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Mol Pharmacol 79:229-40. 2011
    MRP1 (ABCC1) is known to be localized in lipid rafts. Here we show in two different cell lines that localization of Mrp1/MRP1 (Abcc1/ABCC1) in lipid rafts and its function as an efflux pump are dependent on cortical actin...
  45. doi Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury
    Ulrich M Becher
    Medizinische Klinik und Poliklinik II, Innere Medizin, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Mol Cell Cardiol 50:570-7. 2011
    ..We investigated whether release of LTC(4)via the multidrug resistance related protein 1 (MRP1) induces apoptosis in cardiomyocytes in vitro and in vivo.
  46. doi Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, New South Wales, Australia
    Int J Dev Biol 55:45-58. 2011
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal...
  47. doi Function of MRP1/ABCC1 is not dependent on cholesterol or cholesterol-stabilized lipid rafts
    Péter Mészaros
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 437:483-91. 2011
    MRP1 (multidrug-resistance-related protein 1)/ABCC1 (ATP-binding cassette transporter C1) has been localized in cholesterol-enriched lipid rafts, which suggests a role for these lipid rafts and/or cholesterol in MRP1 function...
  48. ncbi Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice
    Aurelio Lorico
    Department of Tumor Biology, Norwegian Radium Hospital, Montebello, 0310, Norway
    Biochem Biophys Res Commun 291:617-22. 2002
    The Multidrug Resistance Protein 1 (MRP1) is a membrane pump that mediates the efflux of a wide variety of xenobiotics, including arsenical and antimonial compounds, as demonstrated by the study of MRP1-transfected cell lines...
  49. ncbi Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994
    N A Doggett
    Life Sciences Division, Los Alamos National Laboratory, NM
    Cytogenet Cell Genet 68:165-84. 1995
  50. ncbi Double knockout of the MRP gene leads to increased drug sensitivity in vitro
    A Lorico
    Department of Pharmacology and Developmental Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 56:5351-5. 1996
    Overexpression of the multidrug resistance-associated protein (MRP) gene has been implicated in the resistance of tumor cell lines to a wide array of chemotherapeutic agents, but its normal physiological function(s) remains unknown...
  51. ncbi Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein
    I Leier
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Eur J Biochem 242:201-5. 1996
    ..present study indicates that this protein represents the murine homolog of the human multidrug resistance protein (MRP)...
  52. ncbi Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells
    B D Stride
    Cancer Research Laboratories, Queen s University, Kingston, Canada K7L 3N6
    Mol Pharmacol 52:344-53. 1997
    Overexpression of the human multidrug-resistance protein (MRP) causes a form of multidrug resistance similar to that conferred by P-glycoprotein, although the two proteins are only distantly related...
  53. pmc Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage
    J Wijnholds
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    J Exp Med 188:797-808. 1998
    The multidrug resistance protein 1 (MRP1) gene encodes a transporter protein that helps to protect cells against xenobiotics...
  54. ncbi Transbilayer movement of NBD-labeled phospholipids in red blood cell membranes: outward-directed transport by the multidrug resistance protein 1 (MRP1)
    D W Dekkers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Biochemistry 37:14833-7. 1998
    ..mice for multidrug resistance P-glycoproteins (Mdr1a/1b-/- and Mdr2-/-) and multidrug resistance protein 1 (Mrp1-/-) revealed that Mrp1 is responsible for the observed flop of the fluorescent lipid analogues...
  55. ncbi New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models
    G Rappa
    Department of Tumor Biology, Norwegian Radium Hospital, Montebello, Oslo
    Biochem Pharmacol 58:557-62. 1999
    Growing interest in the MRP (multidrug resistance protein) gene stems from its importance in multidrug resistance to chemotherapy, its possible use in gene therapy, and its relationship with the glutathione system...
  56. ncbi The multidrug resistance protein family
    P Borst
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands
    Biochim Biophys Acta 1461:347-57. 1999
    The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6...
  57. ncbi Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
    J Konig
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D 69120, Heidelberg, Germany
    Biochim Biophys Acta 1461:377-94. 1999
    ..to glutathione, glucuronate, or sulfate have been identified as members of the multidrug resistance protein (MRP) family...
  58. ncbi Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus
    L M Schriml
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Genomics 64:24-31. 2000
    ..The mouse ABC genes could be grouped into the seven previously described human ABC subfamilies. Three mouse ABC genes mapped to regions implicated in cholesterol gallstone susceptibility...
  59. ncbi A family of drug transporters: the multidrug resistance-associated proteins
    P Borst
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    J Natl Cancer Inst 92:1295-302. 2000
    ..However, MRP1, MRP2, and MRP3 can also cause resistance to neutral organic drugs that are not known to be conjugated to acidic ..
  60. ncbi The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress
    J Hirrlinger
    Physiologisch chemisches Institut der Universität, Tubingen, Germany
    J Neurochem 76:627-36. 2001
    ..In the presence of cyclosporin A and the quinoline-derivative MK571, inhibitors of multidrug resistance proteins (MRP1 and MRP2), glutathione disulfide accumulated in cells and the release of glutathione disulfide from astrocytes ..
  61. ncbi Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice
    H Sun
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Biochem Biophys Res Commun 284:863-9. 2001
    The multidrug resistant-associated protein 1 (MRP1) is a membrane-bound transport protein that is involved in the efflux of organic anions and has been implicated in multidrug resistance in cancer...
  62. ncbi Preparation of an antibody recognizing both human and rodent MRP1
    C Fernetti
    CSF and Department of BBCM, Centro Servizi Polivalenti d Ateneo, University of Trieste, Via Giorgieri 1, Trieste, 34127, Italy
    Biochem Biophys Res Commun 288:1064-8. 2001
    Based on the high level of identity among human, mouse, and rat MRP1 protein sequence, we produced a specific polyclonal antibody (MRP1-A23) against a synthetic polypeptide covering the C-terminus of the human protein...
  63. ncbi cGMP transport by vesicles from human and mouse erythrocytes
    Cornelia J F De Wolf
    Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    FEBS J 274:439-50. 2007
    ..The relative contribution of ABCC4/Abcc4 and ABCG2/Abcg2 in cGMP transport was confirmed with a new inhibitor of ABCC4 transport, the protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride...
  64. ncbi Retroviral transfer of MRP1 and gamma-glutamyl cysteine synthetase modulates cell sensitivity to L-buthionine-S,R-sulphoximine (BSO): new rationale for the use of BSO in cancer therapy
    G Rappa
    Department of Tumor Biology, Norwegian Radium Hospital, Montebello, Oslo 0310, Norway
    Eur J Cancer 39:120-8. 2003
    b>MRP1 (multidrug resistance protein 1) co-exports glutathione (GSH) and drug(s) and exports GSH, glucuronide, and sulphate-conjugated drugs...
  65. ncbi Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells
    Yuji Tanaka
    Third Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu city 514 8507, Japan
    Biochem Biophys Res Commun 309:324-30. 2003
    ..The expression of organic anion transporting polypeptide 1 (oatp1), multidrug resistance-associated protein 1 (mrp1), mrp2, mrp3, and ugt1a1 was not seen in the undifferentiated HNF-3beta-ES cells by RT-PCR, whereas all were ..
  66. ncbi Altered expression of sulfotransferases, glucuronosyltransferases and mrp transporters in FVB/mrp1-/- mice
    L J Bain
    Department of Biological Sciences, University of Texas at El Paso, 79968, USA
    Xenobiotica 33:1173-83. 2003
    ..III (transporter) RNA expression, between FVB mice and mice lacking the multidrug resistance-associated protein 1 (mrp1) gene (FVB/mrp1-/- mice)...
  67. ncbi Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes
    Claire Mercier
    INSERM U26, Hopital Fernand Widal, 200 rue du Faubourg Saint Denis, 75475 Paris Cedex 10, France
    Brain Res 1021:32-40. 2004
    P-glycoprotein (P-gp, ABCB1) and the multidrug resistance-associated protein 1 (Mrp1, ABCC1) are two ATP-driven pumps that mediate the export of organic anions from cells and may confer cellular resistance to many cytotoxic hydrophobic ..
  68. ncbi Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice
    Jonathan M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 33:947-55. 2005
    ..Highest expression of the Mrp family members is as follows: Mrp1 in testes, ovary, and placenta; Mrp2 in intestine, followed by liver and kidney; Mrp3 in large intestine; Mrp4 in ..
  69. ncbi Molecular physiology of renal organic anion transporters
    Takashi Sekine
    Kyorin University School of Medicine, Department of Pharmacology and Toxicology, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Am J Physiol Renal Physiol 290:F251-61. 2006
    ..anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC...
  70. ncbi Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene
    A Lorico
    Department of Pharmacology and Developmental Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 55:4352-60. 1995
    ..Northern blot analyses using the human 10.1 probe for the 3'-terminal region of the multidrug-resistance protein (MRP) cDNA revealed a mRNA species of approximately 6 kb in WEHI-3B/NOVO cells but not in WEHI-3B/S cells...
  71. ncbi Modulation of dendritic cell trafficking to and from the airways
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Immunol 176:3578-84. 2006
    ....
  72. pmc Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression
    Akihiko Kimura
    Department of Forensic Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Am J Pathol 169:1118-28. 2006
    ..NF-E2-related factor (Nrf) 2 protein, a transcription factor crucial for MRP1 gene expression, was similarly increased in the kidneys of both strains of mice after NaAs treatment...
  73. ncbi Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation
    Peter Kleemann
    Institut fuer Medizinische Mikrobiologie und Krankenhaushygiene, University of Marburg, BMFZ, Hans Meerweinstrasse, 35043 Marburg, Germany
    Int Immunol 18:1603-6. 2006
    Previously, we have demonstrated that multidrug-resistance-associated protein 1 (Mrp1) represents an activation marker for murine Th1 cells and is constitutively expressed by Th2 cells...
  74. pmc Development and characterization of multidrug resistant human hepatocarcinoma cell line in nude mice
    Bao Jin Zhai
    Clinical Center for Tumor Therapy of 2nd Affiliated Hospital, Box 153, Institute of Ultra sonic Engineering in Medicine, Chongqing University of Medical Sciences, 1 Medical College Road, Chongqing 400016, China
    World J Gastroenterol 12:6614-9. 2006
    ..To establish a multidrug resistant (MDR) cell sub-line from the human hepatocarcinoma cell line (HepG2) in nude mice...
  75. ncbi Multidrug resistance related protein (ABCC1) and its role on nitrite production by the murine macrophage cell line RAW 264.7
    Daniela F P Leite
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, UFRJ, Rio de Janeiro, RJ, Brazil
    Biochem Pharmacol 73:665-74. 2007
    Multidrug resistance related protein 1 (MRP1/ABCC1) is an ABC transporter protein related to the extrusion of reduced glutathione (GSH), oxidized glutathione (GSSG) and GSH-conjugates, as well as leukotriene C(4) and cyclopentane ..
  76. ncbi Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein
    S Paul
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Biochemistry 35:13647-55. 1996
    b>MRP is a recently described ATP-binding cassette transporter that confers cellular resistance to natural product cytotoxic drugs...

Research Grants1

  1. Role of macrophages in hemangioendothelioma development
    Gayle Gordillo; Fiscal Year: 2008
    ..The current proposal includes didactic and research training elements towards the development of a surgical scientist career of a hispanic woman plastic surgeon. ..