Abcb11

Summary

Gene Symbol: Abcb11
Description: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Alias: ABC16, Bsep, Lith1, PFIC2, PGY4, SPGP, bile salt export pump, ATP-binding cassette, sub-family B, member 11, sister of P-glycoprotein
Species: mouse

Top Publications

  1. doi Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump
    Renxue Wang
    British Columbia Cancer Research Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Hepatology 50:948-56. 2009
  2. ncbi Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein
    Renxue Wang
    British Columbia Cancer Research Center, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Hepatology 38:1489-99. 2003
  3. doi The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity
    Yao Xue Guo
    a Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China
    Toxicol Mech Methods 25:382-7. 2015
  4. doi The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump
    K E R Gooijert
    Research Laboratory Pediatrics, Beatrix Children s Hospital University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 308:G450-7. 2015
  5. pmc Transcriptional dynamics of bile salt export pump during pregnancy: mechanisms and implications in intrahepatic cholestasis of pregnancy
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, College of Pharmacy, University of Rhode Island, Kingston, RI
    Hepatology 60:1993-2007. 2014
  6. pmc LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes
    Laszlo Homolya
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America Laboratory of Molecular Cell Biology, Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 9:e91921. 2014
  7. doi Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice
    Eugene Hrycay
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, V6T1Z3, Canada
    Mol Cell Biochem 389:119-32. 2014
  8. pmc Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, RI 02881
    J Lipid Res 54:3030-44. 2013
  9. doi Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies
    Renxue Wang
    British Columbia Cancer Research Centre, 675 W 10 Ave, Vancouver, BC, Canada V5Z 1L3
    Am J Physiol Gastrointest Liver Physiol 305:G286-94. 2013
  10. pmc Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels
    Laurent Vergnes
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 17:916-28. 2013

Scientific Experts

  • Eric L Klett
  • Victor Ling
  • Masanori Ito
  • Anne S Henkel
  • Beverly J Paigen
  • R M Green
  • C C Paulusma
  • Henk Wolters
  • Renxue Wang
  • Xiulong Song
  • Lin Liu
  • Dana Forrest
  • Yao Xue Guo
  • K E R Gooijert
  • Eugene Hrycay
  • Laszlo Homolya
  • Bingfang Yan
  • Leila Valanejad
  • Ruitang Deng
  • Yuan Chen
  • R Wang
  • Laurent Vergnes
  • Yuanyuan Zhang
  • Ryan M Allen
  • Ping Lam
  • Miriam Cantore
  • Atul R Chopra
  • Jonathan A Sheps
  • Satoki Imai
  • Iván L Csanaky
  • Frank J Gonzalez
  • Curtis D Klaassen
  • Marit J Yska
  • Karen Reue
  • Xingguo Cheng
  • M Huls
  • M James Phillips
  • Jacqueline R M Plass
  • Anne Figge
  • Akihide Kamiya
  • Diane Mignault
  • Ibrahim M Yousef
  • F Hoda
  • Shahid Perwaiz
  • Pei Jiang
  • Qi Zhi Zhang
  • H J Verkade
  • Wen Xing Peng
  • R Havinga
  • Ye Deng
  • Chun Li
  • S Tazuma
  • Xue Fei Xu
  • Lei Yan He
  • Prabuddha Sengupta
  • Shojiro Kikuchi
  • Michal Jarnik
  • Jenny Tai
  • J Silvio Gutkind
  • Ruchi Verma
  • Jack Phan
  • Alexander Vasilenko
  • Irwin M Arias
  • Jean Pierre Gillet
  • Jennifer Lippincott-Schwartz
  • Lynn Vitale-Cross
  • Dong Fu
  • Stelvio Bandiera
  • Anand Deo
  • Rajani Kaimal
  • Robert G Chin
  • Alan F Hofmann
  • Jessica M Lee
  • Johan Auwerx
  • Lee R Hagey
  • Matthew Stoner
  • Geoffrey Neale
  • Angel Baldán
  • David Q H Wang
  • Carolyn J Albert
  • Tyler J Marquart
  • D Q Shih
  • Sarah Thomas
  • David A Ford
  • Fei Li
  • Andrew D Patterson
  • Meenakshisundaram Ananthanarayanan
  • Deepa Nachagari
  • Mary Vore
  • Peter Vogel

Detail Information

Publications40

  1. doi Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump
    Renxue Wang
    British Columbia Cancer Research Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Hepatology 50:948-56. 2009
    b>Bile salt export pump (BSEP; ATP-binding cassette, subfamily B, member 11) mutations in humans result in progressive familial intrahepatic cholestasis type 2, a fatal liver disease with greatly reduced bile flow...
  2. ncbi Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein
    Renxue Wang
    British Columbia Cancer Research Center, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Hepatology 38:1489-99. 2003
    ..bile acid secretion, a process mediated by the sister of P-glycoprotein (Spgp or Abcb11) also known as the bile salt export pump (Bsep)...
  3. doi The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity
    Yao Xue Guo
    a Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China
    Toxicol Mech Methods 25:382-7. 2015
    ..present study investigates whether sodium taurocholate cotransporting polypeptide (NTCP/Ntcp; SLC10A1) and bile salt export pump (BSEP/Bsep; ABCB11) are involved in the anti-tuberculosis medicines induced liver injury...
  4. doi The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump
    K E R Gooijert
    Research Laboratory Pediatrics, Beatrix Children s Hospital University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 308:G450-7. 2015
    Human bile salt export pump (BSEP) mutations underlie progressive familial intrahepatic cholestasis type 2 (PFIC2)...
  5. pmc Transcriptional dynamics of bile salt export pump during pregnancy: mechanisms and implications in intrahepatic cholestasis of pregnancy
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, College of Pharmacy, University of Rhode Island, Kingston, RI
    Hepatology 60:1993-2007. 2014
    b>Bile salt export pump (BSEP) is responsible for biliary secretion of bile acids, a rate-limiting step in the enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor (FXR)...
  6. pmc LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes
    Laszlo Homolya
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America Laboratory of Molecular Cell Biology, Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 9:e91921. 2014
    ..cultures from control and liver-specific LKB1 knockout mice to examine the role of LKB1 in trafficking of ABCB11, the canalicular bile acid transporter...
  7. doi Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice
    Eugene Hrycay
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, V6T1Z3, Canada
    Mol Cell Biochem 389:119-32. 2014
    The bile salt export pump (BSEP/Bsep; gene symbol ABCB11/Abcb11) translocates bile salts across the hepatocyte canalicular membrane into bile in humans and mice...
  8. pmc Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor
    Xiulong Song
    Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island, Kingston, RI 02881
    J Lipid Res 54:3030-44. 2013
    Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver...
  9. doi Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies
    Renxue Wang
    British Columbia Cancer Research Centre, 675 W 10 Ave, Vancouver, BC, Canada V5Z 1L3
    Am J Physiol Gastrointest Liver Physiol 305:G286-94. 2013
    The bile salt export pump (BSEP), encoded by the abcb11 gene, is the major canalicular transporter of bile acids from the hepatocyte...
  10. pmc Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels
    Laurent Vergnes
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 17:916-28. 2013
    ..Diet1 and FGF19 proteins exhibited overlapping subcellular localization in cultured intestinal cells. These results establish Diet1 as a control point in enterohepatic bile acid signaling and lipid homeostasis...
  11. doi Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis
    Masanori Ito
    Department of Pharmacology, School of Medicine, Faculty of Medicine, Toho University, Ota ku, Tokyo, Japan
    Biochim Biophys Acta 1831:459-68. 2013
    ..These results indicate that STARD10 is involved in regulating bile acid metabolism through the modulation of PPARα-mediated mechanism...
  12. pmc Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation
    Anne S Henkel
    Division of Hepatology, Department of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Physiol Gastrointest Liver Physiol 304:G221-6. 2013
    The bile salt export pump, encoded by ABCB11, is the predominant canalicular transport protein for biliary bile acid secretion...
  13. pmc The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane
    Miriam Cantore
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University Dusseldorf, D 40225 Dusseldorf, Germany
    J Biol Chem 286:45014-29. 2011
    ..D'urso, D., Keppler, D., and Häussinger, D. (1997) Gastroenterology 113, 1438-1442) and Bsep retrieval (Schmitt, M., Kubitz, R., Lizun, S., Wettstein, M., and Häussinger, D...
  14. pmc Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice
    Yuanyuan Zhang
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:24784-94. 2012
    The bile salt export pump (BSEP) is an ATP-binding cassette transporter that serves as the primary system for removing bile salts from the liver...
  15. pmc miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity
    Ryan M Allen
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO, USA
    EMBO Mol Med 4:882-95. 2012
    ..We show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that is expressed from within an intron of SREBP-2...
  16. doi The role of bile salt toxicity in the pathogenesis of bile duct injury after non-heart-beating porcine liver transplantation
    Marit J Yska
    Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 85:1625-31. 2008
    ..The role of bile salt toxicity in the development of biliary strictures after NHB liver transplantation is unclear...
  17. pmc Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice
    Anne S Henkel
    Division of Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Gastroenterology 141:1404-11, 1411.e1-2. 2011
    b>ABCB11 is a canalicular transport protein that controls the rate-limiting step in hepatic bile acid secretion. Its expression levels vary in humans, and it is not clear how these variations affect lipid metabolism...
  18. pmc Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 13:35-43. 2011
    ..can be completely rescued by replenishing intestinal BA or by genetically restoring the levels of hepatic bile salt export pump (BSEP)...
  19. pmc Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice
    Iván L Csanaky
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Gastrointest Liver Physiol 297:G419-33. 2009
    ..The mRNA and protein levels of the BA uptake transporter Ntcp were unchanged after PHx, whereas the canalicular Bsep protein increased twofold at 48 h. The basolateral efflux transporter Mrp3 was induced at the mRNA (2...
  20. pmc Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content
    Coen C Paulusma
    AMC Liver Center, Academic Medical Center, Meibergdreef 69 71, 1105 BK, Amsterdam, The Netherlands
    J Biol Chem 284:9947-54. 2009
    ..cholesterol extraction from the canalicular membrane impairs the activity of the bile salt transporter, ABCB11, and as a consequence causes cholestasis...
  21. doi Analysis of DNA methylation and histone modification profiles of liver-specific transporters
    Satoki Imai
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Mol Pharmacol 75:568-76. 2009
    ..underlies the tissue-specific expression of mouse liver-specific transporters (Oatp1b2/Slco1b2, Ntcp/Slc10a1, Bsep/Abcb11, and Abcg5/g8)...
  22. ncbi Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis
    Anne Figge
    Department of Medicine III, University Hospital Aachen, Aachen University, 52074 Aachen, Germany
    J Biol Chem 279:2790-9. 2004
    Abcb11 encodes for the liver bile salt export pump, which is rate-limiting for hepatobiliary bile salt secretion...
  23. ncbi Molecular cloning and characterization of the murine bile salt export pump
    R M Green
    Section of Digestive and Liver Diseases, University of Illinois at Chicago College of Medicine and Chicago Veteran s Administration Medical Center, Westside Division, 840 S Wood St M C 787, Chicago, IL 60612, USA
    Gene 241:117-23. 2000
    ..Recently, the rat sister-of-p-glycoprotein/bile salt export pump (spgp/BSEP) was demonstrated to encode for the rat ATP-dependent canalicular bile salt export protein, and ..
  24. ncbi Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus
    L M Schriml
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Genomics 64:24-31. 2000
    ..The mouse ABC genes could be grouped into the seven previously described human ABC subfamilies. Three mouse ABC genes mapped to regions implicated in cholesterol gallstone susceptibility...
  25. ncbi Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice
    B Paigen
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 4:59-65. 2000
    ..The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK. L-Lith1(s)...
  26. pmc Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis
    R Wang
    British Columbia Cancer Research Center, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 1L3
    Proc Natl Acad Sci U S A 98:2011-6. 2001
    Mutations in the sister of P-glycoprotein (Spgp) or bile salt export pump (BSEP) are associated with Progressive Familial Intrahepatic Cholestasis (PFIC2). Spgp is predominantly expressed in the canalicular membranes of liver...
  27. ncbi Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism
    D Q Shih
    Laboratorie of Metabolic Diseases, The Rockefeller University, New York, New York, USA
    Nat Genet 27:375-82. 2001
    ..Our studies demonstrate that Tcf1, in addition to being an important regulator of insulin secretion, is an essential transcriptional regulator of bile acid and HDL-cholesterol metabolism...
  28. ncbi The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism
    Jack Phan
    Department of Medicine, UCLA and the Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 277:469-77. 2002
    ..Genetic analysis of serum bile acid levels revealed co-segregation with Diet1, indicating that this locus is likely responsible for both increased bile acid excretion and resistance to hypercholesterolemia in B6By mice...
  29. ncbi Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
    Shojiro Kikuchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Genet 31:320-5. 2002
    ..These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs...
  30. ncbi Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice
    Henk Wolters
    Center for Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    J Hepatol 37:556-63. 2002
    ..We investigated the physiological relevance of this regulation by evaluating transporter expression in mice experiencing different transhepatic bile salt fluxes...
  31. ncbi Appearance of atypical 3 alpha,6 beta,7 beta,12 alpha-tetrahydroxy-5 beta-cholan-24-oic acid in spgp knockout mice
    Shahid Perwaiz
    Department of Pharmacology, Université de Montréal and Centre de Recherche de l Hôpital Sainte Justine, Montreal, Canada
    J Lipid Res 44:494-502. 2003
    ..The sister-of-p-glycoprotein (spgp) gene was shown to encode the canalicular bile salt export protein, and mutations in spgp gene were identified as ..
  32. ncbi High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1
    G Bouchard
    The Jackson Laboratory, 600 Main St, Bar Harbor, Maine 04609, USA
    Mamm Genome 10:1070-4. 1999
    ..markers in the D2Mit182 to D2Mit14 region and two candidate genes for Lith1, the canalicular bile salt export pump (Bsep) also known as sister of P-glycoprotein (Spgp) and the low-density-lipoprotein-receptor-related gene ..
  33. ncbi A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump
    Jacqueline R M Plass
    Department of Gastroenterology and Hepatology, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Hepatol 40:24-30. 2004
    ..The disease is caused by mutations in the bile salt export pump (BSEP). Ten different missense mutations have been described...
  34. ncbi Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: implications for cholesterol gallstone formation
    F Hoda
    Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Membr Biol 196:9-14. 2003
    ..Abcb11 encodes for the liver canalicular membrane bile salt export pump (BSEP), which maps to this QTL and is a candidate gene for Lith 1...
  35. pmc A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    BMC Med 2:5. 2004
    ..No phenotypic difference has yet been described in humans with complete defects in either ABCG5 or ABCG8. These proteins, based upon the defects in humans, are responsible for regulating dietary sterol entry and biliary sterol secretion...
  36. ncbi TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices
    Akihide Kamiya
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 40:527-36. 2004
    ..In conclusion, TNFalpha is a suppressive factor of hepatic maturation. The balance between hepatic maturation factor (OSM and extracellular matrices) and TNFalpha is important for liver development...
  37. ncbi Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice
    Ping Lam
    British Columbia Cancer Research Center, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Biochemistry 44:12598-605. 2005
    ..of the ATP binding cassette transporter (ABC) superfamily, known as sister of P-glycoprotein (Spgp) or bile salt export pump (Bsep, ABCB11)...
  38. ncbi Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones
    Anne Henkel
    Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Tarry 14 711, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA
    Mamm Genome 16:903-8. 2005
    ..QTL analysis has identified the Lith 1 loci on mouse Chromosome 2, and the hepatic bile salt transporter Abcb11 maps to the Lith 1 locus...
  39. ncbi ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney
    M Huls
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Kidney Int 69:2186-93. 2006
    ..Abcb11 is the major liver canalicular bile salt export pump. Here we show for the first time expression in the kidney and localization of the transporter to the ..
  40. pmc Regulation of hepatic bile acid transporters Ntcp and Bsep expression
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Biochem Pharmacol 74:1665-76. 2007
    Sodium-taurocholate cotransporting polypeptide (Ntcp) and bile salt export pump (Bsep) are two key transporters for hepatic bile acid uptake and excretion...