NA

Summary

Gene Symbol: NA
Description: neuraminidase
Species: Influenza A virus (A/Goose/Guangdong/1/96(H5N1))

Top Publications

  1. ncbi Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses
    Yasuo Suzuki
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Biol Pharm Bull 28:399-408. 2005
  2. ncbi Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong
    X Xu
    Influenza Branch, Division of Viral Diseases, Center for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
    Virology 261:15-9. 1999
  3. doi Insight into the oseltamivir resistance R292K mutation in H5N1 influenza virus: a molecular docking and molecular dynamics approach
    V Karthick
    Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Cell Biochem Biophys 68:291-9. 2014
  4. pmc Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses
    Donata Kalthoff
    Institutes of Diagnostic Virology
    J Virol 87:13556-68. 2013
  5. doi The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surface
    Guomin Qian
    Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Vet J 202:612-7. 2014
  6. pmc Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture
    Xiangwu Ju
    State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing, China
    J Virol 89:10347-58. 2015
  7. pmc The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidase
    Wentian Chen
    Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi an, People s Republic of China
    PLoS ONE 7:e49224. 2012
  8. pmc NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusion
    Quanjiao Chen
    State Key Laboratory of Virology, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
    PLoS ONE 8:e54334. 2013
  9. ncbi [Biological significance of amino acids deletion in NA stalk of H5N1 avian influenza virus]
    Qu zhi Wang
    Key Laboratory of Animal Infectious Diseases, Ministry of Agriculture, Yangzhou University, Yangzhou 225009, China
    Wei Sheng Wu Xue Bao 46:542-6. 2006
  10. pmc Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice
    Yumiko Matsuoka
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 83:4704-8. 2009

Scientific Experts

  • X Xu
  • Qu zhi Wang
  • DEBI NAYAK
  • Yasuo Suzuki
  • Anne Moscona
  • Xiangwu Ju
  • V Karthick
  • Guomin Qian
  • Donata Kalthoff
  • Quanjiao Chen
  • Wentian Chen
  • Natalia A Ilyushina
  • Baibaswata Nayak
  • Yumiko Matsuoka
  • Yan Zhao
  • Huijun Lu
  • Jianming Zhang
  • Zhu Liang
  • Huandi Zhou
  • Zhen Zou
  • Xiao Li
  • Dangsheng Li
  • Ying Zhong
  • Chengyu Jiang
  • Yanxu Zhang
  • Miaomiao Sheng
  • Yiwu Yan
  • Lifang Zhang
  • Ningyi Jin
  • Fengming Huang
  • Jianchao Du
  • Kangtai Liu
  • Peng Yang
  • Ning Li
  • Qiang Liu
  • Mingyao Tian
  • K Ramanathan
  • Yuhai Chen
  • Xiaomei Zhu
  • Hua Li
  • Xiaojuan Chi
  • Ji Long Chen
  • Haitao Wei
  • Song Wang
  • Martin Beer
  • Jessica Bogs
  • Shengping Huang
  • Bernd Hoffmann
  • Dirk Höper
  • Jianjun Chen
  • Shaoqiong Zhang
  • Susanne Röhrs
  • Ze Chen
  • Jürgen Stech
  • Yaogang Zhong
  • Yannan Qin
  • Shisheng Sun
  • Zheng Li
  • Peter L Collins
  • Sachin Kumar
  • Joshua M DiNapoli
  • Anandan Paldurai
  • Siba K Samal
  • Robert G Webster
  • Jon P Seiler
  • Elena A Govorkova
  • Daniel R Perez
  • Jerold E Rehg
  • David E Swayne
  • Marie Anne Rameix-Welti
  • Kanta Subbarao
  • Colleen Thomas
  • Nadia Naffakh
  • Melanie Altholtz
  • Christine Warnes
  • Ruben Donis

Detail Information

Publications16

  1. ncbi Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses
    Yasuo Suzuki
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Biol Pharm Bull 28:399-408. 2005
    ....
  2. ncbi Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong
    X Xu
    Influenza Branch, Division of Viral Diseases, Center for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
    Virology 261:15-9. 1999
    ..These data suggest that the H5N1 viruses isolated from the Hong Kong outbreaks derived their HA genes from a virus similar to the A/Goose/Guangdong/1/96 virus or shared a progenitor with this goose pathogen...
  3. doi Insight into the oseltamivir resistance R292K mutation in H5N1 influenza virus: a molecular docking and molecular dynamics approach
    V Karthick
    Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Cell Biochem Biophys 68:291-9. 2014
    ..and selective antiviral drug employed to fight the flu virus in infected individuals by inhibiting neuraminidase (NA), a flu protein responsible for the release and spread of the progeny virions...
  4. pmc Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses
    Donata Kalthoff
    Institutes of Diagnostic Virology
    J Virol 87:13556-68. 2013
    ..The resulting mutant acquired major alterations in the neuraminidase (NA)-encoding segment...
  5. doi The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surface
    Guomin Qian
    Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Vet J 202:612-7. 2014
    Influenza virus neuraminidase (NA) is a major viral envelope glycoprotein, which plays a critical role in viral infection...
  6. pmc Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture
    Xiangwu Ju
    State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing, China
    J Virol 89:10347-58. 2015
    ..Here, we show that the neuraminidase (NA) of H5N1 influenza A virus markedly deglycosylates and degrades lysosome-associated membrane proteins (LAMPs; the ..
  7. pmc The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidase
    Wentian Chen
    Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi an, People s Republic of China
    PLoS ONE 7:e49224. 2012
    Two glycoproteins, hemagglutinin (HA) and neuraminidase (NA), on the surface of influenza viruses play crucial roles in transfaunation, membrane fusion and the release of progeny virions...
  8. pmc NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusion
    Quanjiao Chen
    State Key Laboratory of Virology, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
    PLoS ONE 8:e54334. 2013
    Two surface glycoproteins of influenza virus, haemagglutinin (HA) and neuraminidase (NA), play opposite roles in terms of their interaction with host sialic acid receptors...
  9. ncbi [Biological significance of amino acids deletion in NA stalk of H5N1 avian influenza virus]
    Qu zhi Wang
    Key Laboratory of Animal Infectious Diseases, Ministry of Agriculture, Yangzhou University, Yangzhou 225009, China
    Wei Sheng Wu Xue Bao 46:542-6. 2006
    It has been reported that NA gene of some H1N1 Influenza A virus strains isolated since 1933 is characterized by a deletion of 11 to 16 amino acids in the stalk...
  10. pmc Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice
    Yumiko Matsuoka
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 83:4704-8. 2009
    ..and H7 viruses in poultry, the hemagglutinin (HA) can acquire additional glycosylation sites, and the neuraminidase (NA) stalk becomes shorter...
  11. pmc Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunity
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 84:2408-20. 2010
    ..contributions of each of the three HPAIV surface proteins, namely, the hemagglutinin (HA), the neuraminidase (NA), and the M2 proteins, to the induction of HPAIV-neutralizing serum antibodies and protective immunity in chickens...
  12. pmc Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets
    Natalia A Ilyushina
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 6:e1000933. 2010
    The acquisition of neuraminidase (NA) inhibitor resistance by H5N1 influenza viruses has serious clinical implications, as this class of drugs can be an essential component of pandemic control measures...
  13. ncbi Assembly and budding of influenza virus
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Virus Res 106:147-65. 2004
    ..envelope surrounding the vRNP consists of a lipid bilayer containing spikes composed of viral glycoproteins (HA, NA, and M2) on the outer side and M1 on the inner side...
  14. ncbi Neuraminidase inhibitors for influenza
    Anne Moscona
    Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
    N Engl J Med 353:1363-73. 2005

Research Grants4

  1. CLONING AND EXPRESSION OF INFLUENZA VIRAL RNA SEGMENTS
    DEBI NAYAK; Fiscal Year: 2005
    ..Specific objectives are to: (i) define the apical determinants of HA and NA, the envelope viral proteins, (ii) define the interactions of HA and NA with M1, (iii) define the role of envelope ..
  2. INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
    DEBI NAYAK; Fiscal Year: 2007
    ..iv) role of M1 in the exit of vRNP from nucleus into cytoplasm, (v) interaction of M1 with viral glycoproteins (HA, NA and M2), (vi) membrane binding of M1, (vii) dimer/oligomer formation of M1, (viii) role of M1 in virus budding ..
  3. Design of peptide entry inhibitors and delivery systems to target emerging henipa
    Anne Moscona; Fiscal Year: 2008
    ..abstract_text> ..
  4. Design of peptide entry inhibitors and delivery systems to target emerging henipa
    Anne Moscona; Fiscal Year: 2010
    ..abstract_text> ..