Genomes and Genes
Gene Symbol: NA
Species: Influenza A virus (A/Goose/Guangdong/1/96(H5N1))
- Sialobiology of influenza: molecular mechanism of host range variation of influenza virusesYasuo Suzuki
Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
Biol Pharm Bull 28:399-408. 2005....
- Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong KongX Xu
Influenza Branch, Division of Viral Diseases, Center for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
Virology 261:15-9. 1999..These data suggest that the H5N1 viruses isolated from the Hong Kong outbreaks derived their HA genes from a virus similar to the A/Goose/Guangdong/1/96 virus or shared a progenitor with this goose pathogen...
- Insight into the oseltamivir resistance R292K mutation in H5N1 influenza virus: a molecular docking and molecular dynamics approachV Karthick
Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
Cell Biochem Biophys 68:291-9. 2014..and selective antiviral drug employed to fight the flu virus in infected individuals by inhibiting neuraminidase (NA), a flu protein responsible for the release and spread of the progeny virions...
- Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 virusesDonata Kalthoff
Institutes of Diagnostic Virology
J Virol 87:13556-68. 2013..The resulting mutant acquired major alterations in the neuraminidase (NA)-encoding segment...
- The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surfaceGuomin Qian
Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Vet J 202:612-7. 2014Influenza virus neuraminidase (NA) is a major viral envelope glycoprotein, which plays a critical role in viral infection...
- Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome RuptureXiangwu Ju
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Department of Biochemistry and Molecular Biology, Peking Union Medical College, Tsinghua University, Beijing, China
J Virol 89:10347-58. 2015..Here, we show that the neuraminidase (NA) of H5N1 influenza A virus markedly deglycosylates and degrades lysosome-associated membrane proteins (LAMPs; the ..
- The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidaseWentian Chen
Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi an, People s Republic of China
PLoS ONE 7:e49224. 2012Two glycoproteins, hemagglutinin (HA) and neuraminidase (NA), on the surface of influenza viruses play crucial roles in transfaunation, membrane fusion and the release of progeny virions...
- NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusionQuanjiao Chen
State Key Laboratory of Virology, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
PLoS ONE 8:e54334. 2013Two surface glycoproteins of influenza virus, haemagglutinin (HA) and neuraminidase (NA), play opposite roles in terms of their interaction with host sialic acid receptors...
- [Biological significance of amino acids deletion in NA stalk of H5N1 avian influenza virus]Qu zhi Wang
Key Laboratory of Animal Infectious Diseases, Ministry of Agriculture, Yangzhou University, Yangzhou 225009, China
Wei Sheng Wu Xue Bao 46:542-6. 2006It has been reported that NA gene of some H1N1 Influenza A virus strains isolated since 1933 is characterized by a deletion of 11 to 16 amino acids in the stalk...
- Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for miceYumiko Matsuoka
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 83:4704-8. 2009..and H7 viruses in poultry, the hemagglutinin (HA) can acquire additional glycosylation sites, and the neuraminidase (NA) stalk becomes shorter...
- Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunityBaibaswata Nayak
Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
J Virol 84:2408-20. 2010..contributions of each of the three HPAIV surface proteins, namely, the hemagglutinin (HA), the neuraminidase (NA), and the M2 proteins, to the induction of HPAIV-neutralizing serum antibodies and protective immunity in chickens...
- Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferretsNatalia A Ilyushina
Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
PLoS Pathog 6:e1000933. 2010The acquisition of neuraminidase (NA) inhibitor resistance by H5N1 influenza viruses has serious clinical implications, as this class of drugs can be an essential component of pandemic control measures...
- Assembly and budding of influenza virusDebi P Nayak
Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Virus Res 106:147-65. 2004..envelope surrounding the vRNP consists of a lipid bilayer containing spikes composed of viral glycoproteins (HA, NA, and M2) on the outer side and M1 on the inner side...
- Neuraminidase inhibitors for influenzaAnne Moscona
Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
N Engl J Med 353:1363-73. 2005
- CLONING AND EXPRESSION OF INFLUENZA VIRAL RNA SEGMENTSDEBI NAYAK; Fiscal Year: 2005..Specific objectives are to: (i) define the apical determinants of HA and NA, the envelope viral proteins, (ii) define the interactions of HA and NA with M1, (iii) define the role of envelope ..
- INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSESDEBI NAYAK; Fiscal Year: 2007..iv) role of M1 in the exit of vRNP from nucleus into cytoplasm, (v) interaction of M1 with viral glycoproteins (HA, NA and M2), (vi) membrane binding of M1, (vii) dimer/oligomer formation of M1, (viii) role of M1 in virus budding ..
- Design of peptide entry inhibitors and delivery systems to target emerging henipaAnne Moscona; Fiscal Year: 2008..abstract_text> ..
- Design of peptide entry inhibitors and delivery systems to target emerging henipaAnne Moscona; Fiscal Year: 2010..abstract_text> ..