M2

Summary

Gene Symbol: M2
Description: matrix protein 2
Species: Influenza A virus (A/Goose/Guangdong/1/96(H5N1))

Top Publications

  1. ncbi Assembly and budding of influenza virus
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Virus Res 106:147-65. 2004
  2. ncbi Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong
    X Xu
    Influenza Branch, Division of Viral Diseases, Center for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
    Virology 261:15-9. 1999
  3. pmc Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunity
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 84:2408-20. 2010
  4. pmc The nucleoprotein and matrix protein segments of H5N1 influenza viruses are responsible for dominance in embryonated eggs
    Kenta Shimizu
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Gen Virol 92:1645-9. 2011
  5. ncbi Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data
    James D Lear
    Johnson Research Foundation, Department of Biochemistry and Biophysics, School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    FEBS Lett 552:17-22. 2003
  6. ncbi Computational studies of proton transport through the M2 channel
    Yujie Wu
    Department of Chemistry and Henry Eyring Center for Theoretical Chemistry, University of Utah, 315 S 1400 E Rm 2020, Salt Lake City, UT 84112 0850, USA
    FEBS Lett 552:23-7. 2003

Research Grants

Scientific Experts

  • X Xu
  • James Lear
  • DEBI NAYAK
  • Kenta Shimizu
  • Baibaswata Nayak
  • Yujie Wu
  • Hualan Chen
  • Yukiko Muramoto
  • Jiro Arikawa
  • Shinya Yamada
  • Chengjun Li
  • Yoshihiro Kawaoka
  • Anandan Paldurai
  • Sachin Kumar
  • Joshua M DiNapoli
  • Peter L Collins
  • Daniel R Perez
  • Siba K Samal
  • Gregory A Voth

Detail Information

Publications7

  1. ncbi Assembly and budding of influenza virus
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Virus Res 106:147-65. 2004
    ..surrounding the vRNP consists of a lipid bilayer containing spikes composed of viral glycoproteins (HA, NA, and M2) on the outer side and M1 on the inner side...
  2. ncbi Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong
    X Xu
    Influenza Branch, Division of Viral Diseases, Center for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
    Virology 261:15-9. 1999
    ..These data suggest that the H5N1 viruses isolated from the Hong Kong outbreaks derived their HA genes from a virus similar to the A/Goose/Guangdong/1/96 virus or shared a progenitor with this goose pathogen...
  3. pmc Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunity
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 84:2408-20. 2010
    ..of each of the three HPAIV surface proteins, namely, the hemagglutinin (HA), the neuraminidase (NA), and the M2 proteins, to the induction of HPAIV-neutralizing serum antibodies and protective immunity in chickens...
  4. pmc The nucleoprotein and matrix protein segments of H5N1 influenza viruses are responsible for dominance in embryonated eggs
    Kenta Shimizu
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Gen Virol 92:1645-9. 2011
    ..NP and M proteins play key roles in conferring this viral dominance; specifically, a glutamic acid at position 66 in M2 was conserved among the Fujian-like viruses...
  5. ncbi Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data
    James D Lear
    Johnson Research Foundation, Department of Biochemistry and Biophysics, School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    FEBS Lett 552:17-22. 2003
    The M2 proton channel from influenza A virus forms proton-selective ion channels, which are the target of the drug amantadine...
  6. ncbi Computational studies of proton transport through the M2 channel
    Yujie Wu
    Department of Chemistry and Henry Eyring Center for Theoretical Chemistry, University of Utah, 315 S 1400 E Rm 2020, Salt Lake City, UT 84112 0850, USA
    FEBS Lett 552:23-7. 2003
    The M2 ion channel is an essential component of the influenza A virus. This low-pH gated channel has a high selectivity for protons...

Research Grants2

  1. CLONING AND EXPRESSION OF INFLUENZA VIRAL RNA SEGMENTS
    DEBI NAYAK; Fiscal Year: 2005
    ..A detailed understanding of these processes will facilitate the rational development of antiviral agents which could interfere with one or more steps in virus assembly. ..
  2. INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
    DEBI NAYAK; Fiscal Year: 2007
    ..The segment #7 RNA of influenza A viruses encodes two important structural proteins- M1 from unspliced mRNA and M2 from a spliced mRNA...