ZO 1

Summary

Gene Symbol: ZO 1
Description: tight junction protein 1
Alias: ZO-1, tight junction protein ZO-1, zona occludens 1, zonula occludens 1 protein
Species: human

Top Publications

  1. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
  2. pmc Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex
    S A Weed
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Cell Biol 151:29-40. 2000
  3. ncbi The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity
    Klaus Ebnet
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Sci 116:3879-91. 2003
  4. doi Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions
    Chong Wee Liew
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    FEBS Lett 583:49-54. 2009
  5. pmc Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions
    M Itoh
    1Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 154:491-7. 2001
  6. ncbi Localization and differential expression of two isoforms of the tight junction protein ZO-1
    E Willott
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
    Am J Physiol 262:C1119-24. 1992
  7. pmc The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions
    E Willott
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 90:7834-8. 1993
  8. pmc The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy
    M Itoh
    Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Cell Biol 121:491-502. 1993
  9. pmc Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
    J Cell Biol 138:181-92. 1997
  10. pmc ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
    J Haskins
    Department of Cell Biology and Anatomy, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Cell Biol 141:199-208. 1998

Research Grants

  1. Calcitonin in Prostate Growth and Neplasia
    Girish V Shah; Fiscal Year: 2013
  2. John M Flanagan; Fiscal Year: 2016
  3. G alpha 12 and Regulation of Tight Junctions
    Jennifer Hunt; Fiscal Year: 2004
  4. MOLECULAR CHARACTERIZATION OF THE TIGHT JUNCTION
    Mark Mooseker; Fiscal Year: 1993
  5. Shizhen Emily Wang; Fiscal Year: 2016
  6. Genetic and Molecular Mechanisms of Renal Injury
    Hanna Abboud; Fiscal Year: 2007
  7. Del-1 induces therapeutic cerebral angiogenesis
    Yongmei Chen; Fiscal Year: 2007
  8. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
  9. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
  10. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007

Detail Information

Publications221 found, 100 shown here

  1. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
    ..In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development...
  2. pmc Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex
    S A Weed
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Cell Biol 151:29-40. 2000
    ....
  3. ncbi The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity
    Klaus Ebnet
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Sci 116:3879-91. 2003
    ..Our findings suggest that JAM-2 affects endothelial cell junctions by its regulated clustering at intercellular contacts, and they support a role for JAM-2, and possibly JAM-3, in tight junction formation of endothelial cells...
  4. doi Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions
    Chong Wee Liew
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    FEBS Lett 583:49-54. 2009
    ..Interaction with MUPP1 enables the receptor to regulate transepithelial permeability in a pertussis toxin sensitive manner, suggesting that hSSTR3 can activate G-proteins locally at tight junctions...
  5. pmc Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions
    M Itoh
    1Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 154:491-7. 2001
    ..We also discuss the importance of this model from the perspective of the general molecular mechanisms behind the recruitment of PAR proteins to plasma membranes...
  6. ncbi Localization and differential expression of two isoforms of the tight junction protein ZO-1
    E Willott
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
    Am J Physiol 262:C1119-24. 1992
    ..These observations demonstrate the existence and variable expression of ZO-1 isoforms and raise the question whether these isoforms contribute to tight junction diversity in different epithelia...
  7. pmc The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions
    E Willott
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 90:7834-8. 1993
    ..The C-terminal domain of ZO-1, and its alternatively spliced region, appears to confer variable properties unique to tight junctions...
  8. pmc The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy
    M Itoh
    Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Cell Biol 121:491-502. 1993
    ..Possible functions of the 220-kD protein (ZO-1) are discussed with special reference to the molecular mechanism for adherens and tight junction formation...
  9. pmc Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
    J Cell Biol 138:181-92. 1997
    ....
  10. pmc ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
    J Haskins
    Department of Cell Biology and Anatomy, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Cell Biol 141:199-208. 1998
    ..In vitro affinity analyses demonstrated that recombinant 130-kD protein directly interacts with ZO-1 and the cytoplasmic domain of occludin, but not with ZO-2. We propose that this protein be named ZO-3...
  11. ncbi Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes
    S Moroi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    Am J Physiol 274:C1708-17. 1998
    ....
  12. ncbi The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein
    B N Giepmans
    Division of Cellular Biochemistry The Netherlands Cancer Institute Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Curr Biol 8:931-4. 1998
    ..Confocal microscopy revealed that endogenous Cx43 and ZO-1 colocalised at gap junctions. We suggest that ZO-1 serves to recruit signalling proteins into Cx43-based gap junctions...
  13. ncbi The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
    A S Fanning
    Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 273:29745-53. 1998
    ..These observations suggest that one functional role of ZO-1 is to organize components of the tight junction and link them to the cortical actin cytoskeleton...
  14. ncbi Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:5981-6. 1999
    ..These findings indicated that ZO-2 forms a complex with ZO-1/occludin or ZO-1/alpha catenin to establish TJ or AJ domains, respectively...
  15. ncbi In vivo interaction of AF-6 with activated Ras and ZO-1
    T Yamamoto
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Nara, 630 0101, Japan
    Biochem Biophys Res Commun 259:103-7. 1999
    ..Taken together, these results indicate that the Ras-interacting region on AF-6 is structurally similar to that on Raf-1 and on RalGDS and that AF-6 interacts with activated Ras and ZO-1 in vivo...
  16. ncbi Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3
    E S Wittchen
    Department of Cell Biology, University of Alberta, Edmonton T6G 2H7, Canada
    J Biol Chem 274:35179-85. 1999
    ..ZO-3 complexes rather than a trimeric ZO-1.ZO-2.ZO-3 grouping. These studies elucidate direct binding interactions among tight junction-associated proteins, giving insight into their organization as a multimolecular structure...
  17. pmc Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 147:1351-63. 1999
    ..In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed...
  18. pmc Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin
    M Cordenonsi
    Department of Biology, University of Padova, 35121 Padova, Italy
    J Cell Biol 147:1569-82. 1999
    ..We propose that cingulin is a functionally important component of TJ, linking the submembrane plaque domain of TJ to the actomyosin cytoskeleton...
  19. ncbi Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1
    K Ebnet
    Institute of Cell Biology, ZMBE, University of Muenster, D 48149 Muenster, Germany
    J Biol Chem 275:27979-88. 2000
    ..Our results suggest that JAM can be recruited to intercellular junctions by its interaction with the PDZ domain-containing proteins AF-6 and possibly ZO-1...
  20. ncbi MAGUK proteins: structure and role in the tight junction
    L Gonzalez-Mariscal
    Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies CINVESTAV, Ap Postal 14 740, Mexico DF, 07000, Mexico
    Semin Cell Dev Biol 11:315-24. 2000
    ..ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression...
  21. pmc Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures
    A Suzuki
    Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Cell Biol 152:1183-96. 2001
    ..These results indicate that aPKC is involved in the evolutionarily conserved PAR protein complex, and plays critical roles in the development of the junctional structures and apico-basal polarization of mammalian epithelial cells...
  22. ncbi Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin
    A Schmidt
    Institute of Molecular Pharmacology, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Biochem Biophys Res Commun 288:1194-9. 2001
    ..We demonstrate the use of SPR spectroscopy as an effective approach for characterisation of the interactions of junction proteins...
  23. pmc Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress
    Radhakrishna K Rao
    Department of Physiology, University of Tennessee Health Sciences Center, 894 Union Avenue, Memphis, TN 38163, U S A
    Biochem J 368:471-81. 2002
    ..These results show that oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism...
  24. pmc Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
    Peter A Nielsen
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 14:2470-81. 2003
    ..The spatial variation in the interaction of ZO-1 with lens gap junctions is intriguing and is suggestive of multiple dynamic roles for this association...
  25. pmc Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion
    Keiran S M Smalley
    Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 166:1541-54. 2005
    ....
  26. ncbi HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia
    Georgette D Kanmogne
    Department of Pharmacology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neuropathol Exp Neurol 64:498-505. 2005
    ....
  27. ncbi Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1
    Alexandra F Bruce
    National Heart and Lung Institute, Imperial College London, Guy Scadding Building, London, UK
    Cardiovasc Res 77:757-65. 2008
    ..We therefore examined the hypothesis that ZO-1 contributes to reduced expression of Cx43 gap junctions in congestive heart failure...
  28. doi Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells
    Shinichi Nakamuta
    The Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan
    J Neurovirol 14:186-95. 2008
    ..Our results demonstrate the novel molecular mechanisms of the BBB breakdown by gp120...
  29. doi The second PDZ domain of zonula occludens-1 is dispensable for targeting to connexin 43 gap junctions
    Andrew W Hunter
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cell Commun Adhes 15:55-63. 2008
    ..These data demonstrate that ZO-1 targets to GJ edges independently of several known PDZ2-mediated interactions, including ZO-1 homodimerization, heterodimerization with ZO-2, and direct ZO-1 binding to the C-terminal residues of Cx43...
  30. pmc Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling
    Yu Zhong
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 28:7788-96. 2008
    ..Thus, caveolin-1 may provide an effective target to protect against Tat-induced HBMEC dysfunction and the disruption of the BBB in HIV-1-infected patients...
  31. pmc Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions
    Bertha C Elias
    Department of Physiology, Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:1559-69. 2009
    ..This study reveals a unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues...
  32. pmc The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain
    Kris Meerschaert
    Department of Medical Protein Research, VIB, 9000 Ghent, Belgium
    Cell Mol Life Sci 66:3951-66. 2009
    ..This study shows for the first time that ZO isoforms bind PtdInsPs and offers an alternative regulatory mechanism for the formation and stabilisation of protein complexes in the nucleus...
  33. pmc Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions
    David R Raleigh
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Mol Biol Cell 21:1200-13. 2010
    ..The data further suggest that these proteins are best considered as a group with both redundant and unique contributions to epithelial function and tight junction regulation...
  34. pmc Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration
    Lin Huo
    Division of Life Science, Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    EMBO J 30:665-78. 2011
    ....
  35. pmc The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1
    Julian Nomme
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 286:43352-60. 2011
    ..Our x-ray structures and NMR experiments also show for the first time a role for adjacent domains in the binding of ligands to PDZ domains in the MAGUK proteins family...
  36. pmc Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation
    Ting Wang
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Part Fibre Toxicol 9:35. 2012
    ..The mechanism of PM-mediated pathophysiology remains unknown. However, PM is proinflammatory to the endothelium and increases vascular permeability in vitro and in vivo via ROS generation...
  37. pmc HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus
    Sharof M Tugizov
    Department of Medicine, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0512, USA Department of Orofacial Sciences, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0512, USA Electronic address
    Virology 446:378-88. 2013
    ..Our data suggest that HIV-associated TJ disruption of mucosal epithelia may potentiate HPV infection and subsequent development of HPV-associated neoplasia. ..
  38. ncbi Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse
    T Katsube
    Neurogenetics Research Project, Mitsubishi Kasei Institute of Life Sciences, Minamiooya 11, Machida shi, Tokyo 194 8511, Japan
    J Biol Chem 273:29672-7. 1998
    ..The potential roles of the cortactin.ZO-1 complex in cell adhesion and cell signaling are discussed...
  39. ncbi Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells
    P J Kausalya
    Institute of Molecular and Cell Biology, Epithelial Cell Biology Laboratory, Singapore
    FEBS Lett 505:92-6. 2001
    ..e. Cx43 and Cx45) that can associate with ZO proteins indicate that ZO proteins may play a more general role in organizing gap junctions and/or in recruiting signaling molecules that regulate intercellular communication...
  40. ncbi Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1
    Peter A Nielsen
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:38272-83. 2002
    ..9 expression to vascular smooth muscle cells. Furthermore, it was demonstrated that Cx31.9 interacted with ZO-1. Thus, Cx31.9 represents a novel connexin gene that in vivo generates a protein with unique voltage gating properties...
  41. pmc Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain
    X Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7
    Neuroscience 126:611-30. 2004
    ..Further, our findings suggest a scaffolding and/or regulatory role of ZO-1 at the oligodendrocyte side of astrocyte-to-oligodendrocyte gap junctions...
  42. pmc Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA
    Tony Sourisseau
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, United Kingdom
    Mol Cell Biol 26:2387-98. 2006
    ....
  43. pmc The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state
    Le Shen
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 181:683-95. 2008
    ..These data demonstrate that the tight junction undergoes constant remodeling and suggest that this dynamic behavior may contribute to tight junction assembly and regulation...
  44. pmc Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module
    Ming F Lye
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 285:13907-17. 2010
    ..These findings provide insight into the previously observed ability of the U6 region to regulate TJ assembly in vivo and the structural basis for the complex protein interactions of the MAGUK family...
  45. pmc Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
    M Furuse
    Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
    J Cell Biol 127:1617-26. 1994
    ..The coincidence of the sequence necessary for the ZO-1 association with that for the TJ localization suggests that the association with underlying cytoskeletons through ZO-1 is required for occludin to be localized at TJ...
  46. ncbi Maintenance of the epithelial barrier in a bronchial epithelial cell line is dependent on functional E-cadherin local to the tight junctions
    M R West
    GlaxoSmithKline, Gunnelswood Rd, Stevenage, SG1 2NY, UK
    Cell Commun Adhes 9:29-44. 2002
    ..Taken together with the TER measurements, these data suggest compartmentalization of E-cadherin function within 16HBE14o-cells, with only the apical E-cadherin adjacent to the tight junctions contributing to the function of the latter...
  47. pmc Regulated assembly of tight junctions by protein kinase C
    R O Stuart
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Proc Natl Acad Sci U S A 92:6072-6. 1995
    ..junctions, as measured by resistance, was paralleled by a delay in the sorting of the tight-junction protein, zona occludens 1 (ZO-1), to the tight junction...
  48. pmc Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1
    Xinbo Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Ave, Winnipeg, Manitoba, Canada R3E 3J7
    Eur J Neurosci 19:2132-46. 2004
    ..These results demonstrating a Cx36/ZO-1 association suggest a regulatory and/or scaffolding role of ZO-1 at gap junctions that form electrical synapses between neurons in mammalian brain...
  49. ncbi Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases
    B T Hawkins
    Department of Medical Pharmacology, The University of Arizona College of Medicine, 1501 N Campbell Ave, P O Box 245050, Tucson, AZ 85724 5050, USA
    Diabetologia 50:202-11. 2007
    ..We hypothesise that diabetes leads to compromise of BBB tight junctions via stimulation of MMP activity...
  50. pmc Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies
    Prabhakar Rajan
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    BMC Cell Biol 10:82. 2009
    ..Nuclear Sam68 protein is concentrated within subnuclear organelles called SLM/Sam68 Nuclear Bodies (SNBs), which also contain some other splicing regulators, signalling components and nucleic acids...
  51. ncbi Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions
    R Yano
    Laboratory for Cellular Information Processing, Brain Science Institute, RIKEN, Wako, Saitama351 0198, Japan
    Neuroscience 117:373-81. 2003
    ....
  52. ncbi Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement
    N G Schipper
    Department of Pharmaceutics, Uppsala University, Biomedical Center, Sweden
    Pharm Res 14:923-9. 1997
    ..It has recently been shown that the absorption enhancing and toxic effects of chitosans are dependent on their chemical composition. In this study, the mechanisms underlying these effects were investigated at the cellular level...
  53. pmc Circulating plasma factors induce tubular and glomerular alterations in septic burns patients
    Filippo Mariano
    Dipartimento di Area Medica, Unita di Nefrologia e Dialisi, Ospedale CTO, Via G, Zuretti 29, Torino, 10126, Italy
    Crit Care 12:R42. 2008
    ..We then tested the hypothesis that plasma in these patients induces apoptosis and functional alterations that could account for proteinuria and severity of renal dysfunction in tubular cells and podocytes...
  54. ncbi The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1
    A Johansson
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    J Cell Sci 113:3267-75. 2000
    ..These findings, together with the reported roles of PAR-6 and PAR-3 in C. elegans, suggest that Cdc42 and Rac1 and PAR-6/PAR-3 are involved in the establishment of cell polarity in epithelial cells...
  55. ncbi Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL
    Torsten W Schulz
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, 69120 Heidelberg, Germany
    J Neurosci 24:8584-94. 2004
    ..of the AMPA receptor transport by a PDZ (postsynaptic density-95/Drosophila disc large tumor suppressor zona occludens 1) and LIM (Lin11/rat Isl-1/Mec3) domain-containing protein, RIL (reversion-induced LIM protein)...
  56. ncbi Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    Peter Fickert
    Deparment of Medicine, Medical University, Graz, Austria
    Gastroenterology 127:261-74. 2004
    ....
  57. pmc N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression
    Jordan P Steinberg
    Howard Hughes Medical Institute and Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:18212-6. 2004
    ..These findings demonstrate that interaction of AMPA receptors with N-ethylmaleimide-sensitive factor plays a critical role in incorporation of AMPA receptors into synapses and for their subsequent removal during cerebellar LTD...
  58. doi Reproductive hormones regulate the selective permeability of the blood-brain barrier
    Andrea C Wilson
    Department of Medicine, University of Wisconsin Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705 USA
    Biochim Biophys Acta 1782:401-7. 2008
    ..The expression and localization of the cytoplasmic membrane-associated tight junction protein zona occludens 1 (ZO-1) in microvessels was not altered among groups indicating that the increased paracellular permeability ..
  59. doi Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability
    A Alhamoruni
    School of Graduate Entry Medicine and Health, Royal Derby Hospital, University of Nottingham, Nottingham, United Kingdom
    J Pharmacol Exp Ther 335:92-102. 2010
    ....
  60. doi eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain
    Elizabeth Beauchesne
    Neuroscience Research Unit, Saint Luc Hospital CHUM, Montreal, Quebec, Canada
    J Neurochem 111:452-9. 2009
    ..However, eNOS gene deletion only partially attenuated TD-related neuronal cell loss, suggesting the presence of mechanisms additional to BBB disruption in the pathogenesis of these changes...
  61. pmc Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis
    Tzu Hsuan Yeh
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hepatology 52:1410-9. 2010
    ..KO mice had bile canalicular morphologic abnormalities as evidenced by staining for F-actin and zona occludens 1. Electron microscopy revealed dilated and tortuous bile canaliculi in KO livers along with decreased ..
  62. ncbi PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits
    Norbert Bannert
    Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Biol Chem 278:42190-9. 2003
    ..Alternatively, an intracellular complex of npro-IL-16, ion channels, and components of myosin motors in neurons suggests a role in protein targeting...
  63. ncbi Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber CA3 pyramid synapses
    Michelle T W Ho
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:11651-62. 2007
    ..Together, these findings indicate that the transient participation of CP-AMPARs at young MF-PYR synapses dictates the developmental window to observe DiLTD...
  64. doi Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus
    Ebba Norsted
    Department of Neuroscience, The Retzius Laboratory, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    J Chem Neuroanat 36:107-21. 2008
    ..These vessels may represent a route of entry for circulating substances to a subpopulation of arcuate nucleus neurons...
  65. pmc Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus)
    Rebecca R Bellone
    Department of Biology, University of Tampa, Tampa, FL 33606, USA
    Genetics 179:1861-70. 2008
    ..Decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both CSNB and LP in horses...
  66. pmc Nicotine promotes tumor growth and metastasis in mouse models of lung cancer
    Rebecca Davis
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 4:e7524. 2009
    ..This effect was observed when nicotine was administered through intraperitoneal injections, or through over-the-counter transdermal patches...
  67. doi ZO-1 is involved in trophoblastic cell differentiation in human placenta
    Guillaume Pidoux
    Institut National de la Sante et de la Recherche Medicale, U767, Paris, USA
    Am J Physiol Cell Physiol 298:C1517-26. 2010
    ..Moreover, zona occludens 1 (ZO-1) was localized mainly at the intercellular boundaries between human trophoblastic cells...
  68. doi Pigment epithelium-derived factor inhibits advanced glycation end products-induced retinal vascular permeability
    Sardarpasha Sheikpranbabu
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University Kalasalingam Academy of Research and Education, Anand Nagar, Tamilnadu, India
    Biochimie 92:1040-51. 2010
    ....
  69. ncbi Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia
    C B Collares-Buzato
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, UK
    Eur J Cell Biol 76:85-92. 1998
    ....
  70. ncbi Pericyte abundance affects sucrose permeability in cultures of rat brain microvascular endothelial cells
    Fiona E Parkinson
    Department of Pharmacology and Therapeutics, University of Manitoba, A203 753 McDermot Avenue, Winnipeg, MB, Canada R3E 0T6
    Brain Res 1049:8-14. 2005
    ..After 2-14 days in vitro (DIV), immunohistochemistry of these cells showed strong labeling for zona occludens 1 (ZO-1), a tight junction protein expressed in endothelial cells...
  71. doi Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vessels
    Jeong Hun Kim
    Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    J Neurosci Res 87:653-9. 2009
    ..Moreover, ZO-1 as well as occludin or claudin might demonstrate the tightness of blood-retina barrier in developing retina...
  72. doi Escherichia albertii and Hafnia alvei are candidate enteric pathogens with divergent effects on intercellular tight junctions
    Kevin A Donato
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Room 8409, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Microb Pathog 45:377-85. 2008
    ..These findings demonstrate that E. albertii and H. alvei are candidate enteric pathogens that have both strain-specific and host epithelial cell-dependent effects...
  73. doi Distribution of serotonin receptors and interacting proteins in the human sigmoid colon
    N Chetty
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
    Neurogastroenterol Motil 21:551-8, e14-5. 2009
    ..In conclusion, these results show that there is variation in distribution of 5-HT receptors and interacting proteins within the sigmoid colon that may contribute to colonic function...
  74. ncbi MgSO4 treatment preserves the ischemia-induced reduction in S-100 protein without modification of the expression of endothelial tight junction molecules
    Felipe Goñi-de-Cerio
    Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, Leioa, Vizcaya, Spain
    Histol Histopathol 24:1129-38. 2009
    ..We also characterized BBB dysfunction in terms of the levels of expression of a panel of BBB proteins; Occludin, Claudin, Zona Occludens-1, Zonula Occludens-2, VE-cadherin and beta-catenin. Lambs were assigned to:..
  75. doi Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines
    Evemie Dube
    INRS Institut Armand Frappier, University of Quebec, 531 Boulevard des Prairies, Laval, Quebec, Canada
    Biol Reprod 82:1119-28. 2010
    ..Disruption of CLDN1, CLDN3, CLDN4, and CLDN7 could, therefore, lead to epididymal dysfunction, resulting in male infertility...
  76. doi Regulation of testicular tight junctions by gonadotrophins in the adult Djungarian hamster in vivo
    Gerard A Tarulli
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Reproduction 135:867-77. 2008
    ....
  77. doi Protein components of the blood-brain barrier (BBB) in the brainstem area postrema-nucleus tractus solitarius region
    Nasren Maolood
    Department of Neuroscience, The Retzius Laboratory, Retzius vag 8, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Chem Neuroanat 37:182-95. 2009
    ..Such vessels may represent a route of entry for circulating substances to neurons in the NTS that inter alia regulate energy balance...
  78. pmc Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo
    Vernadeth B Alarcon
    Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    Biol Reprod 83:347-58. 2010
    ....
  79. pmc MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome
    Veronica Sanchez Freire
    Department of Cell Biology, Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Am J Pathol 176:288-303. 2010
    ..Our findings further the knowledge of the molecular mechanisms of BPS, and have relevance for other clinical conditions involving the NK1 receptor...
  80. pmc A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia
    B W LeBlanc
    Department of Surgery, Rhode Island Hospital, Brown Alpert Medical School and Department of Neuroscience, Brown University, Providence, RI 02903, USA
    Neuroscience 167:490-500. 2010
    ..we predicted that CN2097, a peptide-based macrocycle of nine residues that binds to the PSD-95 Discs large, Zona occludens 1 (PDZ) domains of PSD-95, would interfere with physiologic phenomena in the spinal cord related to central ..
  81. ncbi Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes
    Irwin I Singer
    Immunology and Rheumatology, Merck and Co, Inc, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Immunol 175:7151-61. 2005
    ..of S1P1, and treatment with FTY-P resulted in intense staining and colocalization of CD31, beta-catenin, and zona occludens 1 in junctions between sinus cells...
  82. ncbi Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors
    Matthew S Kayser
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:12152-64. 2006
    ..These results demonstrate that EphB2 acts to control the organization of specific classes of mature glutamatergic synapses...
  83. ncbi PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area
    Wei Feng
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    J Biol Chem 277:41140-6. 2002
    ..Our data uncover a novel PDZ domain-mediated protein interaction mode that may be responsible for multimerization of other PDZ domain-containing scaffold proteins...
  84. doi Effect of major abdominal surgery on the host immune response to infection
    Klaus Buttenschoen
    Department of Surgery, University of Alberta, Alberta, Canada
    Curr Opin Infect Dis 23:259-67. 2010
    ..The present review summarizes key studies on the effects of major abdominal surgery on the host response to infection published during the last 18 months...
  85. pmc N- and C-terminal domains of beta-catenin, respectively, are required to initiate and shape axon arbors of retinal ganglion cells in vivo
    Tamira M Elul
    Department of Physiology, University of California San Francisco, San Francisco, California 94143, USA
    J Neurosci 23:6567-75. 2003
    ....
  86. ncbi Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes
    Joshua B Silverman
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:8505-16. 2007
    ..Thus, the interaction of scaffolding proteins with cadherin-NPRAP complexes may anchor diverse signaling and adhesion molecules at cadherins...
  87. doi Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma
    Yu Chih Chao
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Am J Respir Crit Care Med 179:123-33. 2009
    ..Claudin (CLDN)-1, a key component of tight junction complexes, was down-regulated in human lung adenocarcinomas...
  88. doi Temporal differentiation and maturation of regenerated rat urothelium
    Christopher C Roth
    Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BJU Int 103:836-41. 2009
    ....
  89. ncbi Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters
    Sunita DeSouza
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 22:3493-503. 2002
    ..and glutamate receptor-interacting protein (GRIP) are two similar PDZ (postsynaptic density 95/Discs large/zona occludens 1) proteins that interact with glutamate receptors 2 and 3 (GluR2 and GluR3) subunits...
  90. ncbi HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition
    Monika Heiner
    Institute of Biochemistry, Justus Liebig University of Giessen, Giessen, Germany
    RNA Biol 7:56-64. 2010
    ..In sum, our data provide new insights into the mechanisms of how hnRNP L-bound to intronic sites-regulates exon recognition...
  91. doi TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner
    Eline Remue
    Department of Medical Protein Research, VIB, Gent, Belgium
    FEBS Lett 584:4175-80. 2010
    ..We propose that zonula occludens is a negative regulator of TAZ and suggest that selected tight junction proteins control nuclear translocation and activity of TAZ...
  92. pmc Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier
    Marianne Strazza
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Res 1399:96-115. 2011
    ....
  93. pmc Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102
    Stéphanie A D Bonnet
    Molecular Neurobiology and Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, European Neuroscience Institute, D 37077 Gottingen, Germany
    J Neurosci 33:13398-409. 2013
    ..These results depict a protein domain-based multifunctional aspect of PSD-95 in regulating excitatory synaptic transmission and unveil a novel form of domain-based interplay between signaling scaffolds of the DLG-MAGUK family. ..
  94. pmc A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin
    Saara Hämälistö
    Center for Biotechnology, University of Turku, Turku, Finland
    PLoS ONE 8:e70696. 2013
    ..Altogether, our results identify a novel regulatory pathway involving the interplay between ZO-1, α5-integrin and PKCε in the late stages of mammalian cell division. ..
  95. ncbi Steps in the morphogenesis of a polarized epithelium. I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts
    A Z Wang
    Institute for Cancer Research, Philadelphia, PA 19111
    J Cell Sci 95:137-51. 1990
    ..We suggest that the mechanisms involved in triggering cell polarity may be common to different polarized epithelia in vivo...
  96. pmc Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology
    S W Ryeom
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 11:1687-96. 2000
    ..The localizations of endogenous ZO-1 and another family member, ZO-2, were disrupted. These findings suggest that ZO-1 may participate in regulation of cellular differentiation...
  97. ncbi Specific AHNAK expression in brain endothelial cells with barrier properties
    Benoit J Gentil
    Laboratoire de Transduction du Signal INSERM EMI 0104, Grenoble, France
    J Cell Physiol 203:362-71. 2005
    ..Our results identify AHNAK as a protein marker of endothelial cells with barrier properties...
  98. ncbi Transsynaptic signaling by postsynaptic synapse-associated protein 97
    Maria Paz Regalado
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Palo Alto, California 94304 5485, USA
    J Neurosci 26:2343-57. 2006
    ....
  99. ncbi Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons
    Bryen A Jordan
    Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Neurosci 10:427-35. 2007
    ..We propose that AIDA-1d mediates a link between synaptic activity and control of protein biosynthetic capacity by regulating nucleolar assembly...
  100. pmc Adiponectin regulates albuminuria and podocyte function in mice
    Kumar Sharma
    Translational Research in Kidney Disease, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0711, La Jolla, California 92093 0711, USA
    J Clin Invest 118:1645-56. 2008
    ..These results suggest that adiponectin is a key regulator of albuminuria, likely acting through the AMPK pathway to modulate oxidant stress in podocytes...
  101. pmc Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells
    Michael J Lafemina
    Univ of California, San Francisco, NCIRE VAMC, 94121, USA
    Am J Physiol Lung Cell Mol Physiol 299:L724-34. 2010
    ..In addition, these data demonstrate the complete claudin expression profile for AT1 and AT2 cells and indicate that claudins-3, -4, and -18 are the primary claudins expressed in these cell types...

Research Grants31

  1. Calcitonin in Prostate Growth and Neplasia
    Girish V Shah; Fiscal Year: 2013
    ..The goal of this application is to elucidate early molecular events associated with CTR-stimulated TJ disassembly that lead to increased tumor growth/metastasis. ..
  2. John M Flanagan; Fiscal Year: 2016
    ..studies build upon our previously published and unpublished data implicating Occ, and its binding partner zona occludens 1 (ZO-1) protein, in regulating barrier properties conferred by TJs...
  3. G alpha 12 and Regulation of Tight Junctions
    Jennifer Hunt; Fiscal Year: 2004
    ..The perseverance with which Dr. Hunt has maintained her "finger in the research pie" despite the rigors of Medical school and residency training underscore her commitment to research. ..
  4. MOLECULAR CHARACTERIZATION OF THE TIGHT JUNCTION
    Mark Mooseker; Fiscal Year: 1993
    ..Studies to verify the expression of a ZO-1 homolog, together with initial genetic characterization are proposed...
  5. Shizhen Emily Wang; Fiscal Year: 2016
    ..g., miR-105) in BC patients as blood-borne markers for early diagnosis or prediction of metastasis. ..
  6. Genetic and Molecular Mechanisms of Renal Injury
    Hanna Abboud; Fiscal Year: 2007
    ..It is anticipated that the studies will advance the understanding of genetic, biochemical, and cellular factors that modulate renal response to injury. ..
  7. Del-1 induces therapeutic cerebral angiogenesis
    Yongmei Chen; Fiscal Year: 2007
    ..The results from this study may lead to the development of a clinically significant stroke therapy. [unreadable] [unreadable] [unreadable]..
  8. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  9. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  10. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  11. Role of Par Genes in the Early Mouse Embryo
    VERNADETH ALARCON; Fiscal Year: 2006
    ..An understanding of cell polarization in the mouse embryo should have significant benefit for human health research related to reproductive problems. ..
  12. Integrin Signaling in Nervous System Development
    Louis Reichardt; Fiscal Year: 2009
    ..They should also contribute to our understanding of the signaling pathways through which an important family of axon guidance molecules controls axon growth, branching and guidance. ..
  13. Role of Clic in Epithelial Morphogenesis
    Mark Berryman; Fiscal Year: 2008
    ..The fruit fly will be used as a model system to understand how Clic works with other genes and proteins known to be important for cell shape and movement during embryonic development. [unreadable] [unreadable] [unreadable]..
  14. Role for Vav Family Proteins in T Lymphocyte Activation
    Wojciech Swat; Fiscal Year: 2008
    ..abstract_text> ..
  15. Molecular & Cellular Neurobiology 2008 Gordon Research Conference
    Louis Reichardt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. Dendritic Cells in Salivary Mucosal Immune Responses
    NANCY O SULLIVAN; Fiscal Year: 2008
    ..abstract_text> ..
  17. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Synapse-to-nucleus signaling components in PSDs
    BRYEN JORDAN; Fiscal Year: 2007
    ..This work will increase our understanding of synaptic function which is critical in learning and memory. ..
  19. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  20. Nephronectin-dependent signaling in kidney development
    Louis Reichardt; Fiscal Year: 2007
    ..We will attempt to determine which of these pathways are activated by nephronectin-engagement of a8bl and which are compromised by the absence of a8bl in the metanephric mesenchyme. ..
  21. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ..abstract_text> ..
  22. NeuroAIDS in Cameroon: Molecular determinants
    GEORGETTE KANMOGNE; Fiscal Year: 2008
    ..It will provide knowledge on the epidemiology of neuroAIDS in Cameroon and build the capacity for future neuroAIDS research and therapeutic testing in Cameroon. [unreadable] [unreadable] [unreadable]..
  23. Type 2 Diabetes Gene Discovery Linked to 3p in Hispanics
    Donna Lehman; Fiscal Year: 2009
    ..In addition, the utilization of a novel statistical functional genomic analysis (BQTN) in the 3rd specific aim of this proposal should enhance the final stage of identifying the specific variants involved. ..
  24. MECHANISMS OF SIGNALING BY ACTIVATING RECEPTORS IN INNATE IMMUNE SYSTEMS CELLS
    WOJCIECH A SWAT; Fiscal Year: 2010
    ..abstract_text> ..
  25. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Donna M Lehman; Fiscal Year: 2010
    ..5 LOD support interval. Furthermore, the utilization of a novel statistical functional genomic analysis (Bayesian quantitative trait nucleotide analysis) should enhance the final stage of identifying the specific variants involved. ..
  26. Regulation of NK Cell Function by Vav-family Proteins
    Wojciech Swat; Fiscal Year: 2006
    ..ITAM-containing adaptors. Here, we propose to use several in vitro and in vivo approaches to determine Vav mechanism in NK cell function and development of natural cytotoxicity against virally-infected and tumor cells. ..
  27. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  28. HIV-1 gp120-induced Endothelial Cell Dysfunction
    GEORGETTE KANMOGNE; Fiscal Year: 2007
    ....
  29. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    ..protective factors in breast milk, and provide the basis for further characterization of the mechanisms involved in mucosal protection by breast milk, and their role in preventing neonatal gastrointestinal diseases ..
  30. Expression of the coxsackievirus and adenovirus receptor
    Christopher Cohen; Fiscal Year: 2002
    ..The experiments outlined below will define CAR's function in virus infection of epithelial cells, and its contribution to the formation and structure of the epithelial tight junction. ..