ZNF804A

Summary

Gene Symbol: ZNF804A
Description: zinc finger protein 804A
Alias: C2orf10, zinc finger protein 804A
Species: human

Top Publications

  1. ncbi High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
    T C Islam
    Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Leukemia 17:1880-90. 2003
  2. doi ZNF804A and schizophrenia susceptibility in Asian populations
    Ming Li
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Am J Med Genet B Neuropsychiatr Genet 159:794-802. 2012
  3. doi ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuroimage 54:2132-7. 2011
  4. doi Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroimage 54:2514-23. 2011
  5. doi The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suite, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1459-64. 2010
  6. doi ZNF804A and cortical thickness in schizophrenia and bipolar disorder
    Orjan Bergmann
    KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Psychiatry Res 212:154-7. 2013
  7. doi ZNF804A may be associated with executive control of attention
    Z Balog
    Department of Physiology, University of Szeged, Faculty of Medicine, Szeged National Psychiatry Center, Balassa u 6, Budapest, Hungary
    Genes Brain Behav 10:223-7. 2011
  8. doi Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development
    Matthew J Hill
    Department of Neuroscience, Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 169:1301-8. 2012
  9. doi Less cognitive and neurological deficits in schizophrenia patients carrying risk variant in ZNF804A
    Maarten J A Van Den Bossche
    Applied Molecular Genomics Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium
    Neuropsychobiology 66:158-66. 2012
  10. doi Evidence of sex-modulated association of ZNF804A with schizophrenia
    Fengyu Zhang
    Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:914-7. 2011

Scientific Experts

Detail Information

Publications89

  1. ncbi High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
    T C Islam
    Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Leukemia 17:1880-90. 2003
    ..Furthermore, some genes with previously unknown function, such as C11orf32, C2orf10, TBC1D9 and ABCA6 were found to be differentially expressed in MCL compared to reactive lymphoid tissue...
  2. doi ZNF804A and schizophrenia susceptibility in Asian populations
    Ming Li
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Am J Med Genet B Neuropsychiatr Genet 159:794-802. 2012
    b>ZNF804A, a recently identified risk gene for schizophrenia, has been extensively investigated and the principle finding for this locus has been the association with SNP rs1344706 in populations of European ancestries...
  3. doi ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Neuroimage 54:2132-7. 2011
    b>ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis...
  4. doi Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuroimage 54:2514-23. 2011
    ..significant risk variants for this highly heritable disorder, the rs1344706 single nucleotide polymorphism in ZNF804A, was recently shown to modulate connectivity in healthy carriers during working memory (WM) in a pattern ..
  5. doi The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suite, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1459-64. 2010
    A recent genome-wide association study showed that a variant (rs1344706) in the ZNF804A gene was associated with schizophrenia and bipolar disorder...
  6. doi ZNF804A and cortical thickness in schizophrenia and bipolar disorder
    Orjan Bergmann
    KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Psychiatry Res 212:154-7. 2013
    b>ZNF804A SNP rs1344706 confers genome-wide risk for schizophrenia and bipolar disorder. Both disorders affect cortical thickness...
  7. doi ZNF804A may be associated with executive control of attention
    Z Balog
    Department of Physiology, University of Szeged, Faculty of Medicine, Szeged National Psychiatry Center, Balassa u 6, Budapest, Hungary
    Genes Brain Behav 10:223-7. 2011
    b>ZNF804A, encoding the transcription factor zinc-finger protein 804A, is a genome-wide supported psychosis gene associated with schizophrenia and bipolar disorder...
  8. doi Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development
    Matthew J Hill
    Department of Neuroscience, Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 169:1301-8. 2012
    The single-nucleotide polymorphism rs1344706, located within an intron of the ZNF804A gene, exhibits genome-wide significant association with schizophrenia...
  9. doi Less cognitive and neurological deficits in schizophrenia patients carrying risk variant in ZNF804A
    Maarten J A Van Den Bossche
    Applied Molecular Genomics Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium
    Neuropsychobiology 66:158-66. 2012
    The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia...
  10. doi Evidence of sex-modulated association of ZNF804A with schizophrenia
    Fengyu Zhang
    Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:914-7. 2011
    The single nucleotide polymorphism (SNP) rs1344706 in ZNF804A (2q32.1) has been associated with schizophrenia in a genome-wide association study (GWAS)...
  11. doi Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
    Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 495:216-20. 2011
    ..A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association ..
  12. pmc The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 36:1871-8. 2011
    Schizophrenia and bipolar disorder share genetic risk, brain vulnerability, and clinical symptoms. The ZNF804A risk variant, rs1344706, confers susceptibility for both disorders...
  13. pmc Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 69:885-92. 2012
    CONTEXT The single-nucleotide polymorphism rs1344706 in the gene ZNF804a has been associated with schizophrenia and with quantitative phenotypic features, including brain structure volume and the core symptoms of schizophrenia...
  14. doi Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia
    Sibylle G Schwab
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Schizophr Res 147:46-52. 2013
    Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases...
  15. doi Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:1207-17. 2011
    ..connectivity with other brain areas in schizophrenia and association of these patterns with a putative susceptibility gene (ZNF804A). However, whether these patterns are trait phenomena linked to genetic risk for illness is unclear.
  16. doi Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706
    Rui Zhang
    Department of Genetics and Molecular Biology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi 710061, PR China
    Schizophr Res 141:40-7. 2012
    Recent accumulating evidence has indicated that ZNF804A (zinc finger protein 804A) may be one of the most robustly implicated genes in schizophrenia...
  17. doi Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia
    Ming Li
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, China
    Am J Psychiatry 168:1318-25. 2011
    b>ZNF804A is a schizophrenia risk gene that was recently identified by genome-wide association studies as well as subsequent replications...
  18. pmc An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain
    Emma Sprooten
    Division of Psychiatry, University of Edinburgh, EH10 5HF, United Kingdom
    Magn Reson Imaging 30:1373-80. 2012
    b>ZNF804A, a genomewide supported susceptibility gene for schizophrenia and bipolar disorder, has been associated with task-independent functional connectivity between the left and right dorsolateral prefrontal cortices...
  19. pmc Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling
    J Becker
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Transl Psychiatry 2:e136. 2012
    ..For this purpose, we genotyped the schizophrenia-associated risk variants within zinc-finger protein 804A (ZNF804A), transcription-factor 4 and neurogranin in a large dyslexia case-control sample...
  20. pmc ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
    Matthew J Girgenti
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America
    PLoS ONE 7:e32404. 2012
    b>ZNF804a was identified by a genome-wide association study (GWAS) in which a single nucleotide polymorphism (SNP rs1344706) in ZNF804a reached genome-wide statistical significance for association with a combined diagnosis of schizophrenia ..
  21. pmc Evidence of IQ-modulated association between ZNF804A gene polymorphism and cognitive function in schizophrenia patients
    Min Chen
    School of Mental Health, Jining Medical University, Jining 272013, Shandong Province, P R China
    Neuropsychopharmacology 37:1572-8. 2012
    b>ZNF804A gene polymorphism rs1344706 has been suggested as the most compelling case of a candidate gene for schizophrenia by a genome-wide association study and several replication studies...
  22. doi Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis
    Rui Zhang
    Department of Genetics and Molecular Biology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi 710061, PR China
    Schizophr Res 133:159-64. 2011
    ..significant association of the single nucleotide polymorphism (SNP) rs1344706 (located in intron 2 of the zinc finger protein 804A (ZNF804A) on chromosome 2q32.1) with schizophrenia...
  23. doi Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion
    Matthew J Hill
    Department of Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Hum Mol Genet 21:1018-24. 2012
    ..first genome-wide significant association with the broad phenotype of psychosis was with a polymorphism in the ZNF804A gene. However, the biological function(s) of ZNF804A have, to date, been entirely unknown...
  24. doi Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9...
  25. pmc The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes
    Gary Donohoe
    Department of Psychiatry, Trinity College Dublin, Trinity Health Sciences Building, St James s Hospital, Dublin 8, Ireland
    Schizophr Bull 36:904-9. 2010
    As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity...
  26. pmc A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes
    Todd Lencz
    Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 35:2284-91. 2010
    b>ZNF804A is one of the strongest candidate genes for schizophrenia (SZ), yet its function and role in disease pathophysiology are largely unknown...
  27. doi Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia
    James T R Walters
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 67:692-700. 2010
    The Zinc Finger Protein 804A gene (ZNF804A) has been implicated in schizophrenia susceptibility by several genome-wide association studies. ZNF804A is brain expressed but of unknown function.
  28. doi Neural mechanisms of a genome-wide supported psychosis variant
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Science 324:605. 2009
    ..variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706)...
  29. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010
    A recent genome-wide association study reported association between schizophrenia and the ZNF804A gene on chromosome 2q32.1...
  30. doi No evidence that rare coding variants in ZNF804A confer risk of schizophrenia
    S Dwyer
    MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1411-6. 2010
    ..001%) coding variants in the schizophrenia susceptibility gene ZNF804A are involved in this disorder...
  31. pmc Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
    H J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 16:429-41. 2011
    A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1...
  32. pmc Expanding the range of ZNF804A variants conferring risk of psychosis
    S Steinberg
    deCODE Genetics, Reykjavik, Iceland
    Mol Psychiatry 16:59-66. 2011
    ..However, one variant, rs1344706[T], had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1...
  33. doi Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task
    H Walter
    Department of Psychiatry and Psychotherapy, Division of Mind and Brain Research, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Mol Psychiatry 16:462-70. 2011
    ..network is altered in healthy risk allele carriers of the single-nucleotide polymorphism rs1344706 in the gene ZNF804A, a recently discovered risk variant for psychosis with genome-wide support...
  34. doi Genetics of psychotropic medication induced side effects in two independent samples of bipolar patients
    Chiara Fabbri
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy
    J Neural Transm (Vienna) 122:43-58. 2015
    ..ST8SIA2), second messenger cascades (GSK3B, MAPK1, and CREB1), circadian rhythms (RORA), transcription (SP4, ZNF804A), and monoaminergic system (HTR2A and COMT) in the risk of neurological, psychic, autonomic, and other ADRs...
  35. pmc Postnatal neurodevelopmental expression and glutamate-dependent regulation of the ZNF804A rodent homologue
    Eric H Chang
    Center for Psychiatric Neuroscience, North Shore LIJ Health System, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA Department of Psychiatry Research, North Shore LIJ Health System, Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA Electronic address
    Schizophr Res 168:402-10. 2015
    The zinc finger protein ZNF804A rs1344706 variant is a replicated genome-wide significant risk variant for schizophrenia and bipolar disorder...
  36. doi ZNF804A Genetic Variation Confers Risk to Bipolar Disorder
    Chen Zhang
    Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Neurobiol 53:2936-43. 2016
    Genetic variation in the gene encoding zinc finger protein 804A gene (ZNF804A) has been identified to be associated with bipolar disorder in genome-wide association studies, while little is known regarding their association in Asian ..
  37. doi ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca
    Andreea Zaharie
    Department of Psychiatry, University of Medicine and Pharmacy Iuliu Hatieganu Cluj, Cluj Napoca, Romania
    Genet Test Mol Biomarkers 16:1135-7. 2012
    The ZNF804A rs1344706 variant was the first risk factor to be identified through genome-wide association studies and follow-up studies with meta-analysis for schizophrenia as well as bipolar disorders; we investigated 231 schizophrenia ..
  38. doi Elevated P3b latency variability in carriers of ZNF804A risk allele for psychosis
    Christopher W N Saville
    Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Freiburg, Hauptstrasse 8, Freiburg 79104, Germany School of Psychology, Bangor University, Penrallt Road, Bangor, Gwynedd LL57 2AS, UK
    Neuroimage 116:207-13. 2015
    ..Here we examine the association between P3b latency variability and a polymorphism on the ZNF804A gene associated with psychosis...
  39. pmc No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
    Helena Cousijn
    Department of Psychiatry, University of Oxford, Oxford, UK
    Schizophr Res 159:329-32. 2014
    Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown...
  40. pmc Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137
    Albert H Kim
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 141:60-4. 2012
    ..2011) as hsa-miR-137 targets. Here, using in silico, cellular and luciferase based approaches we also provide evidence that another well replicated candidate schizophrenia gene, ZNF804A, is also target for hsa-miR-137.
  41. doi ZNF804A genetic variation (rs1344706) affects brain grey but not white matter in schizophrenia and healthy subjects
    I Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Psychol Med 45:143-52. 2015
    Genetic variation in the gene encoding ZNF804A, a risk gene for schizophrenia, has been shown to affect brain functional endophenotypes of the disorder, while studies of white matter structure have been inconclusive.
  42. pmc Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway
    Kristin K Nicodemus
    Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity College Dublin, St James Hospital, Dublin, Ireland2Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland
    JAMA Psychiatry 71:778-85. 2014
    ..the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), polygenic scores, and epistatic ..
  43. pmc Heat shock alters the expression of schizophrenia and autism candidate genes in an induced pluripotent stem cell model of the human telencephalon
    Mingyan Lin
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 9:e94968. 2014
    ..as well as those coding for NGFR and a number of SZ and ASD candidates, including SMARCA2, DPP10, ARNT2, AHI1 and ZNF804A. The degree to which the expression of these genes decrease or increase during HS is similar to that found in ..
  44. pmc Effects of ZNF804A on auditory P300 response in schizophrenia
    T O'Donoghue
    1 Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland 2 Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
    Transl Psychiatry 4:e345. 2014
    The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies...
  45. pmc Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex
    Ilaria Guella
    Functional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    Schizophr Res 152:111-6. 2014
    The rs1344706, an intronic SNP within the zinc-finger protein 804A gene (ZNF804A), was identified as one of the most compelling risk SNPs for schizophrenia (SZ) and bipolar disorder (BD)...
  46. pmc ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies
    Carl Christoph Schultz
    To whom correspondence should be addressed Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07740 Jena, Germany tel 49 3641 9 35665, fax 49 3641 9 35444, E mail
    Schizophr Bull 40:532-41. 2014
    Recent evidence indicated that the ZNF804A (rs1344706) risk allele A is associated with better cognitive performance in patients with schizophrenia...
  47. pmc Imputation-based meta-analysis of severe malaria in three African populations
    Gavin Band
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS Genet 9:e1003509. 2013
    ....
  48. doi Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure
    P J Michael Deans
    Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London
    Biol Psychiatry . 2016
    Variation in the gene encoding zinc finger binding protein 804A (ZNF804A) is associated with schizophrenia and bipolar disorder...
  49. doi How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis
    Jonathan L Hess
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory PsychGENe Lab, Departments of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York
    Am J Med Genet B Neuropsychiatr Genet 165:28-40. 2014
    The gene that encodes zinc finger protein 804A (ZNF804A) became a candidate risk gene for schizophrenia (SZ) after surpassing genome-wide significance thresholds in replicated genome-wide association scans and meta-analyses...
  50. ncbi Evaluation of the relationship between the ZNF804A single nucleotide polymorphism rs1344706 A/C variant and schizophrenia subtype in Han Chinese patients
    Yongfeng Yang
    The Second Affiliated Hospital of Xinxiang Medical University, China
    Int J Psychiatry Med 45:269-78. 2013
    Recent genome wide association studies (GWASs) assessing the relationship between schizophrenia (SZ) and the ZNF804A gene, particularly the single nucleotide polymorphism (SNP) rs1344706, have yielded conflicting results...
  51. doi Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia
    Jinbei Zhang
    Department of Psychiatry, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Compr Psychiatry 53:1044-8. 2012
    The single-nucleotide polymorphism rs1344706 located in the ZNF804A zinc finger protein 804A gene is a well-established genome-wide significant variant for schizophrenia...
  52. pmc Brain vs behavior: an effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia
    Emma Jane Rose
    Department of Psychiatry, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
    Schizophr Bull 39:518-26. 2013
    ..and imaging studies of 9 robust SZ risk genes (DAOA, DISC1, DTNBP1, NRG1, RGS4, NRGN, CACNA1C, TCF4, and ZNF804A) published between January 2005-November 2011...
  53. pmc Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
    Ilaria Guella
    Functional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    J Psychiatr Res 47:1215-21. 2013
    ..Neuroimage 2010;53:839-47.]. We investigated the expression levels of miR-137 and three candidate target genes (ZNF804A, CACNA1C, TCF4) in the DLPFC of postmortem brain tissue from 2 independent cohorts: (1) 26 subjects (10 control (..
  54. pmc Meta-analysis indicates that the European GWAS-identified risk SNP rs1344706 within ZNF804A is not associated with schizophrenia in Han Chinese population
    Ming Li
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, People s Republic of China
    PLoS ONE 8:e65780. 2013
    ..Rs1344706, an intronic SNP within ZNF804A, was identified as one of the most compelling candidate risk SNPs for schizophrenia in Europeans through genome-..
  55. pmc Potential Impact of miR-137 and Its Targets in Schizophrenia
    Carrie Wright
    Department of Neurosciences, Health Sciences Center, University of New Mexico Albuquerque, NM, USA
    Front Genet 4:58. 2013
    ..the schizophrenia gene resource (SZGR) database, we found that in addition to CSMD1, C10orf26, CACNA1C, TCF4, and ZNF804A, five schizophrenia risk genes whose transcripts are also validated miR-137 targets, there are other ..
  56. pmc ZNF804A genotype modulates neural activity during working memory for faces
    David E J Linden
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
    Neuropsychobiology 67:84-92. 2013
    ..Genetic imaging studies link the SZ risk variant rs1344706 on the ZNF804A gene to psychosis via alterations in functional brain connectivity during WM, but no work has looked at the ..
  57. pmc Variation in psychosis gene ZNF804A is associated with a refined schizotypy phenotype but not neurocognitive performance in a large young male population
    Nicholas C Stefanis
    To whom correspondence should be addressed Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, The University of Western Australia and North Metropolitan Health Service Mental Health, Gascoyne House, John XXIII Avenue, Mt Claremont, WA 6010, Perth, Australia tel 08 9347 6439, fax 08 9384 5128, E mail
    Schizophr Bull 39:1252-60. 2013
    Genetic variability within the ZNF804A gene has been recently found to be associated with schizophrenia and bipolar disorder, although the pathways by which this gene may confer risk remain largely unknown...
  58. pmc No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study
    Qinling Wei
    Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, PR China
    Neurosci Lett 532:64-9. 2013
    ..Of the many susceptibility genes identified so far, ZNF804A (rs1344706) is the first common genetic variant associated with schizophrenia on a genome-wide level...
  59. pmc Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways
    Anthony J Griswold
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Mol Genet 21:3513-23. 2012
    ..glutamate receptors (GRID1, GRIK2 and GRIK4), synaptic regulators (NRXN3, SLC6A8 and SYN3), transcription factor (ZNF804A) and RNA-binding protein FMR1...
  60. doi A polymerase chain reaction-restriction fragment length polymorphism method for screening ZNF804A gene polymorphism (rs1344706) in patients with schizophrenia: a significant association
    Ali Sazci
    Department of Medical Biology and Genetics, University of Kocaeli, Kocaeli, Turkey
    Genet Test Mol Biomarkers 16:157-61. 2012
    The original ZNF804A rs1344706 risk variant was identified through genome-wide association studies as a risk factor for schizophrenia...
  61. doi The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:193-7. 2012
    ..A new schizophrenia susceptibility gene, the zinc-finger gene ZNF804A, has recently been identified...
  62. pmc Connectomic intermediate phenotypes for psychiatric disorders
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South VIC, Australia
    Front Psychiatry 3:32. 2012
    ..suggesting that the penetrance of candidate risk variants for mental illness, such as those in SLC6A4, MAOA, ZNF804A, and APOE, may be higher for IPs characterized at the level of distributed neural systems than at the level of ..
  63. pmc Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 149:525-37. 2012
    ..g., CHD8, KIRREL3, and ZNF507), and (4) genes associated with later-onset psychiatric disorders (e.g., TCF4, ZNF804A, PDE10A, GRIN2B, and ANK3)...
  64. doi Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia
    Carissa Nadia Kuswanto
    Research Division, Institute of Mental Health, Singapore
    Am J Med Genet B Neuropsychiatr Genet 159:255-62. 2012
    Genome-wide association, case association genetic and meta-analytic studies have highlighted ZNF804A as a robust genome-wide supported susceptibility gene for schizophrenia (SCZ)...
  65. doi REVIEW: Genome-wide findings in schizophrenia and the role of gene-environment interplay
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, The Netherlands
    CNS Neurosci Ther 16:e185-92. 2010
    ..association studies have identified a number of common polymorphisms robustly associated with schizophrenia, in ZNF804A, transcription factor 4, major histocompatibility complex, and neurogranin...
  66. doi [Progress in locating the genetic causes of schizophrenia]
    R Mossner
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum, Sigmund Freud Strasse 25, 53127, Bonn, Deutschland
    Nervenarzt 80:6, 8, 10-1. 2009
    ..The zinc finger domain-containing gene ZNF804A could be identified as a new schizophrenia susceptibility gene, while large copy number variants at 1q21...
  67. pmc Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses
    Nick Craddock
    Schizophr Bull 35:482-90. 2009
    ..genetic associations have been reported at common polymorphisms within ANK3 and CACNA1C in bipolar disorder and ZNF804A in schizophrenia and a relatively specific association between common variation in GABA(A) receptor genes and ..
  68. doi Schizophrenia genetics: advancing on two fronts
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Curr Opin Genet Dev 19:266-70. 2009
    ..Genome-wide association studies have identified at least one common allele of small effect at ZNF804a, which encodes a putative zinc finger binding protein, as well as possible roles for other loci...
  69. doi Genetics of psychosis; insights from views across the genome
    Michael C O'Donovan
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Heath Park, Cardiff CF23 6BQ, UK
    Hum Genet 126:3-12. 2009
    ..to specific risk loci than have earlier studies, specifically for the zinc finger binding protein 804A (ZNF804A) locus in schizophrenia and for the calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) and ..
  70. doi What have the genomics ever done for the psychoses?
    M Gill
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, School of Medicine, Trinity College Dublin 8, Ireland
    Psychol Med 40:529-40. 2010
    ..Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed...
  71. doi SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution
    Yann Loe-Mie
    INSERM U675 U894, Centre Psychiatrie and Neurosciences, Universite Paris Descartes, 75014 Paris, France
    Hum Mol Genet 19:2841-57. 2010
    ..We further found that 8 (CSF2RA, HIST1H2BJ, NOTCH4, NRGN, SHOX, SMARCA2, TCF4 and ZNF804A) out of 10 genome-wide supported SZ-associated genes are part of an interacting network (including SMARCA2), 5 ..
  72. pmc New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
    Vanessa Nieratschker
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, Germany
    Front Behav Neurosci 4:23. 2010
    ..However, results from the first systematic genome-wide association (GWA) studies have implicated variants within ZNF804A, NRGN, TCF4, and variants in the MHC region on chromosome 6p22.1...
  73. pmc Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8
    Hyun Joo Chung
    Department of Anatomy, Embryology Laboratory, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Republic of Korea
    J Biomed Biotechnol 2010:231708. 2010
    Using a ChIP-cloning technique, we identified a Zinc finger protein 804a (Zfp804a) as one of the putative Hoxc8 downstream target genes...
  74. doi The refinement of the critical region for the 2q31.2q32.3 deletion syndrome indicates candidate genes for mental retardation and speech impairment
    Alessandro Cocchella
    Division of Medical Genetics, Galliera Hospital, Genova, Italy
    Am J Med Genet B Neuropsychiatr Genet 153:1342-6. 2010
    ..The critical region points to a few genes, namely NEUROD1, ZNF804A, PDE1A, and ITGA4, which are good candidates to explain the cognitive and behavioural phenotype, as well as the ..
  75. doi Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population
    D Schanze
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:198-203. 2011
    ..SNPs) supported association, with the strongest evidence for SNP-marker rs1344706 at the zinc finger ZNF804A locus on chromosome 2q32.1 (P = 1.61 × 10−7)...
  76. doi Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: what have we learnt?
    Kok Wei Lee
    Institute of Mental Health Woodbridge Hospital 10, Buangkok View, Singapore 539747, Singapore
    Neurosci Biobehav Rev 36:556-71. 2012
    ..2 × 10(-8)) include zinc finger binding protein 804A (ZNF804A), major histocompatibility (MHC) region on chromosome 6, neurogranin (NRGN) and transcription factor 4 (TCF4)...
  77. pmc Effects of cis-regulatory variation differ across regions of the adult human brain
    Federica Buonocore
    Centre for the Cellular Basis of Behaviour, Department of Neuroscience, The James Black Centre, Institute of Psychiatry, King s College London, 125 Coldharbour Lane, London, UK
    Hum Mol Genet 19:4490-6. 2010
    ..expression to measure cis-effects on the RNA expression of five candidate genes for neuropsychiatric illness (ZNF804A, NOS1, RGS4, AKT1 and TCF4) across multiple discrete brain regions within individual subjects...
  78. pmc RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders
    Mingyan Lin
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 6:e23356. 2011
    ..spectrum disorders (ASD) that function as transcription factors and chromatin modifiers, such as POU3F2 and ZNF804A, and genes coding for cell adhesion proteins implicated in these conditions including NRXN1 and NLGN1...
  79. doi The neurobiology of schizophrenia: new leads and avenues for treatment
    Nicholas J Bray
    Department of Neuroscience, Institute of Psychiatry, King s College London, UK
    Curr Opin Neurobiol 20:810-5. 2010
    ..These include ZNF804A, TCF4 and NRGN, which contain common variants that weakly increase schizophrenia susceptibility, and NRXN1, in ..
  80. doi Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..directly implicated one of the best supported schizophrenia-associated loci, zinc finger binding protein 804A (ZNF804A), as showing trans-disorder effects, and the same is true for one of the best supported bipolar loci, calcium ..
  81. doi Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia
    Qinling Wei
    Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 36:122-7. 2012
    b>ZNF804A gene polymorphism rs1344706, the first genetic risk variant to achieve genome wide significance for schizophrenia, has been linked to neural functional connectivity...
  82. doi Bipolar disorder risk alleles in adult ADHD patients
    E T Landaas
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Genes Brain Behav 10:418-23. 2011
    ..We therefore wanted to examine whether the reported BD genetic variants in CACNA1C, ANK3, MYO5B, TSPAN8 and ZNF804A loci are associated with ADHD or with scores on the Mood Disorder Questionnaire (MDQ), a commonly used screening ..
  83. doi Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells
    Erika Pedrosa
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York 10416, USA
    J Neurogenet 25:88-103. 2011
    ..transcription factors/chromatin remodeling proteins and synaptic proteins relevant to SZ pathogenesis, including ZNF804A, RELN, CNTNAP2, CTNNA2, SMARCA2, and NRXN1...
  84. doi ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype
    Tristram A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    World J Biol Psychiatry 12:392-7. 2011
    OBJECTIVES. The ANK3, CACNA1C and ZNF804A genes have been implicated in both bipolar disorders (BPD) and schizophrenia (SCZ)...

Research Grants6

  1. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
    ..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  2. MOLECULAR GENETICS OF AUTISM
    Thomas Wassink; Fiscal Year: 2006
    ..The WNT2 findings will be further examined in two-independent patient samples. ..
  3. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010
    ....
  4. Identifying & Characterizing Prodromal Schizophrenia
    Todd Lencz; Fiscal Year: 2007
    ..This study will provide the candidate with the knowledge and research experience necessary to apply for an R01 to expand upon this research from a neurodevelopmental perspective. ..
  5. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Brien Riley; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. Identifying Molecular Subtypes of Schizophrenia: A Novel Genomic Approach
    Todd Lencz; Fiscal Year: 2010
    ..Findings will create new opportunities for diagnosis and prediction of schizophrenia, and for understanding its biology. ..