ZNF366

Summary

Gene Symbol: ZNF366
Description: zinc finger protein 366
Alias: DCSCRIPT, zinc finger protein 366
Species: human

Top Publications

  1. ncbi Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators
    Vassilis Triantis
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 176:1081-9. 2006
  2. pmc ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
    Jorge Lopez-Garcia
    Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nucleic Acids Res 34:6126-36. 2006
  3. doi Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation
    M Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biochim Biophys Acta 1806:193-9. 2010
  4. pmc Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Erasmus Medical Center, Rotterdam, GE, The Netherlands
    Breast Cancer Res 12:R103. 2010
  5. doi DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells
    Marleen Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 72:1708-17. 2012
  6. doi Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Immunol 189:138-45. 2012
  7. doi DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Immunol 190:3172-9. 2013
  8. ncbi Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences
    Patrick Gilligan
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore
    Gene 294:35-44. 2002
  9. pmc DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells
    Marleen Ansems
    Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands
    Breast Cancer Res Treat 149:693-703. 2015
  10. pmc Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide association study
    Bruno Borghese
    Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cité, CNRS UMR 8104, 75014 Paris, France INSERM, U1016, 75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, Service de gynécologie obstétrique 2 et médecine de la reproduction, Hopital Cochin, Hôpitaux Universitaires Paris Centre, AP HP, 74014 Paris, France
    Biomed Res Int 2015:461024. 2015

Scientific Experts

  • Douglas P Kiel
  • Marleen Ansems
  • Anieta M Sieuwerts
  • A Malarstig
  • Saartje Hontelez
  • Gosse J Adema
  • Vassilis Triantis
  • Jun Wang
  • P Arjunan
  • Jonas Nørskov Søndergaard
  • Bruno Borghese
  • Maaike W Looman
  • Nina Karthaus
  • Maaike W G Looman
  • Jorge Lopez-Garcia
  • Kaiyu Wang
  • A El-Awady
  • Christopher J Secombes
  • R O Dannebaum
  • Catherine Collins
  • Ottavia Benedicenti
  • Tiehui Wang
  • C W Cutler
  • Jun Zou
  • G Kunde-Ramamoorthy
  • Susanna Poghosyan
  • Daniel Vaiman
  • Frank Letourneur
  • Françoise Mondon
  • Florence Busato
  • Pauline Louche
  • Charles Chapron
  • Magalie de Surville
  • Jorg Tost
  • Patrick Gilligan
  • Malou Zuidscherwoude
  • Parmjit Jat
  • David M Heery
  • Tahereh Kamalati
  • Simak Ali
  • Karin B Kindle
  • Malcolm G Parker
  • Mark Christian
  • Maria Leao
  • Lakjaya Buluwela
  • Richard A J Janssen
  • Ross S Thomas
  • Manikandan Periyasamy
  • Franca C Hartgers
  • Dagmar Eleveld Trancikova
  • Byrappa Venkatesh
  • Sydney Brenner

Detail Information

Publications15

  1. ncbi Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators
    Vassilis Triantis
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 176:1081-9. 2006
    ..Taken together, our results show that we have isolated a novel DC marker that could be involved in transcriptional repression. In contrast to other DC molecules, DC-SCRIPT identifies all DC subsets tested to date...
  2. pmc ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
    Jorge Lopez-Garcia
    Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nucleic Acids Res 34:6126-36. 2006
    ..Using ERalpha as bait in a yeast two-hybrid screen, we have identified a novel ERalpha-interacting protein, ZNF366, which is a potent corepressor of ERalpha activity...
  3. doi Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation
    M Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biochim Biophys Acta 1806:193-9. 2010
    ..In this review, we will focus on novel insights in balancing NR activity via NR crosstalk and DC-SCRIPT/ZNF366, a bi-functional NR coregulator. The impact on breast cancer development and prognosis will be discussed.
  4. pmc Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Erasmus Medical Center, Rotterdam, GE, The Netherlands
    Breast Cancer Res 12:R103. 2010
    ....
  5. doi DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells
    Marleen Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 72:1708-17. 2012
    ..We recently found that DC-SCRIPT is a prognostic marker in breast cancer and a unique NR coregulator differentially regulating different classes of NRs. Here we investigated the importance of DC-SCRIPT in prostate cancer...
  6. doi Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Immunol 189:138-45. 2012
    ..we isolated and characterized the cDNA-encoding dendritic cell-specific transcript (DC-SCRIPT; also known as ZNF366)...
  7. doi DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Immunol 190:3172-9. 2013
    ..These data imply that by controlling GR function and GILZ expression DC-SCRIPT is potentially involved in the balance between tolerance and immunity...
  8. ncbi Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences
    Patrick Gilligan
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore
    Gene 294:35-44. 2002
    ..Two of the novel genes contain zinc finger domains and are designated ZNF366 and ZNF367. They map to human chromosomes 5q13.2 and 9q22.32, respectively...
  9. pmc DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells
    Marleen Ansems
    Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands
    Breast Cancer Res Treat 149:693-703. 2015
    ..Recently, we have identified DC-SCRIPT (ZNF366) as a co-suppressor of ERα and as a strong and independent prognostic marker in ESR1 (ERα gene)-positive breast ..
  10. pmc Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide association study
    Bruno Borghese
    Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cité, CNRS UMR 8104, 75014 Paris, France INSERM, U1016, 75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, Service de gynécologie obstétrique 2 et médecine de la reproduction, Hopital Cochin, Hôpitaux Universitaires Paris Centre, AP HP, 74014 Paris, France
    Biomed Res Int 2015:461024. 2015
    ..Rs4703908, located close to ZNF366, provided a higher risk of OMA (OR = 2.22; 95% CI: 1.26-3.92) and DIE, especially with bowel involvement (OR = 2...
  11. doi DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation
    Jonas Nørskov Søndergaard
    Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525GA Nijmegen, The Netherlands
    J Immunol 195:1498-505. 2015
    ..These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates activation of NF-κBp65 after TLR activation in human DCs. ..
  12. doi High-throughput sequencing reveals key genes and immune homeostatic pathways activated in myeloid dendritic cells by Porphyromonas gingivalis 381 and its fimbrial mutants
    P Arjunan
    Department of Periodontics, Georgia Regents University, Augusta, GA, USA
    Mol Oral Microbiol 31:78-93. 2016
    ..and quantitative polymerase chain reaction results show that DPG3, which solely expresses Mfa1, increased ZNF366, CD209, LOX1, IDO1, IL-10, CCL2, SOCS3, STAT3 and FOXO1 gene expression...
  13. doi Characterisation of ZBTB46 and DC-SCRIPT/ZNF366 in rainbow trout, transcription factors potentially involved in dendritic cell maturation and activation in fish
    Jun Wang
    Scottish Fish Immunology Research Centre, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK Department of Basic Veterinary, Sichuan Agricultural University, Huimin Road No 211, Chengdu 611130, China
    Dev Comp Immunol . 2016
    ZBTB46 and DC-SCRIPT/ZNF366 are two zinc finger transcription factors that play important roles in regulating differentiation of dendritic cells in mammals...
  14. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
    ..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms...
  15. pmc Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
    Anders Malarstig
    Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Blood 114:1417-22. 2009
    ..Novel associations were found for SNPs near the ZNF366 gene (lead SNP rs7445013; discovery stage: adjusted beta = -0.12, P = 5...