ZNF366

Summary

Gene Symbol: ZNF366
Description: zinc finger protein 366
Alias: DCSCRIPT
Species: human

Top Publications

  1. ncbi Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators
    Vassilis Triantis
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 176:1081-9. 2006
  2. pmc ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
    Jorge Lopez-Garcia
    Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nucleic Acids Res 34:6126-36. 2006
  3. ncbi Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences
    Patrick Gilligan
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore
    Gene 294:35-44. 2002
  4. doi Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Immunol 189:138-45. 2012
  5. doi DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells
    Marleen Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 72:1708-17. 2012
  6. doi DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Immunol 190:3172-9. 2013
  7. pmc Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Erasmus Medical Center, Rotterdam, GE, The Netherlands
    Breast Cancer Res 12:R103. 2010
  8. pmc Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
    Anders Malarstig
    Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Blood 114:1417-22. 2009
  9. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
  10. doi Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation
    M Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biochim Biophys Acta 1806:193-9. 2010

Scientific Experts

  • Douglas P Kiel
  • Anieta M Sieuwerts
  • A Malarstig
  • Saartje Hontelez
  • Marleen Ansems
  • Gosse J Adema
  • Nina Karthaus
  • Maaike W Looman
  • Vassilis Triantis
  • M Ansems
  • Jorge Lopez-Garcia
  • Patrick Gilligan
  • Jack A Schalken
  • Malou Zuidscherwoude
  • Tilly Aalders
  • Gerald W Verhaegh
  • N Karthaus
  • P N Span
  • G J Adema
  • S Hontelez
  • Parmjit Jat
  • Dagmar Eleveld Trancikova
  • Maria Leao
  • Tahereh Kamalati
  • Ross S Thomas
  • Mark Christian
  • Manikandan Periyasamy
  • David M Heery
  • Simak Ali
  • Maaike W G Looman
  • Franca C Hartgers
  • Lakjaya Buluwela
  • Karin B Kindle
  • Richard A J Janssen
  • Malcolm G Parker
  • Sydney Brenner
  • Byrappa Venkatesh

Detail Information

Publications10

  1. ncbi Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators
    Vassilis Triantis
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 176:1081-9. 2006
    ..Taken together, our results show that we have isolated a novel DC marker that could be involved in transcriptional repression. In contrast to other DC molecules, DC-SCRIPT identifies all DC subsets tested to date...
  2. pmc ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
    Jorge Lopez-Garcia
    Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nucleic Acids Res 34:6126-36. 2006
    ..Using ERalpha as bait in a yeast two-hybrid screen, we have identified a novel ERalpha-interacting protein, ZNF366, which is a potent corepressor of ERalpha activity...
  3. ncbi Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences
    Patrick Gilligan
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore
    Gene 294:35-44. 2002
    ..Two of the novel genes contain zinc finger domains and are designated ZNF366 and ZNF367. They map to human chromosomes 5q13.2 and 9q22.32, respectively...
  4. doi Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Immunol 189:138-45. 2012
    ..we isolated and characterized the cDNA-encoding dendritic cell-specific transcript (DC-SCRIPT; also known as ZNF366)...
  5. doi DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells
    Marleen Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 72:1708-17. 2012
    ..We recently found that DC-SCRIPT is a prognostic marker in breast cancer and a unique NR coregulator differentially regulating different classes of NRs. Here we investigated the importance of DC-SCRIPT in prostate cancer...
  6. doi DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells
    Saartje Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Immunol 190:3172-9. 2013
    ..These data imply that by controlling GR function and GILZ expression DC-SCRIPT is potentially involved in the balance between tolerance and immunity...
  7. pmc Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Erasmus Medical Center, Rotterdam, GE, The Netherlands
    Breast Cancer Res 12:R103. 2010
    ....
  8. pmc Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
    Anders Malarstig
    Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Blood 114:1417-22. 2009
    ..Novel associations were found for SNPs near the ZNF366 gene (lead SNP rs7445013; discovery stage: adjusted beta = -0.12, P = 5...
  9. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
    ..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms...
  10. doi Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation
    M Ansems
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biochim Biophys Acta 1806:193-9. 2010
    ..In this review, we will focus on novel insights in balancing NR activity via NR crosstalk and DC-SCRIPT/ZNF366, a bi-functional NR coregulator. The impact on breast cancer development and prognosis will be discussed.