ZFP57

Summary

Gene Symbol: ZFP57
Description: ZFP57 zinc finger protein
Alias: C6orf40, TNDM1, ZNF698, bA145L22, bA145L22.2, zinc finger protein 57 homolog, zfp-57, zinc finger protein 698
Species: human

Top Publications

  1. ncbi Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system
    Maria B Duran Alonso
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 279:25653-64. 2004
  2. pmc In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
    Simon Quenneville
    School of Life Sciences and Frontiers in Genetics Program, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Mol Cell 44:361-72. 2011
  3. pmc A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints
    Xiajun Li
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:547-57. 2008
  4. doi Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57
    Deborah J G Mackay
    Division of Human Genetics, University of Southampton, Southampton SO16 6YD, UK
    Nat Genet 40:949-51. 2008
  5. ncbi A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation
    S Okazaki
    Department of Biochemistry, Kumamoto University School of Medicine, Japan
    J Biol Chem 269:6900-7. 1994
  6. ncbi A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron
    Yan Wang
    Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
    Nucleic Acids Res . 2016
  7. pmc Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57
    Katharine Plant
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Hum Genet 22:568-71. 2014
  8. doi The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells
    Y Tada
    Department of Stem Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan
    Oncogene 34:752-60. 2015
  9. pmc High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism
    Alessandra Cirillo
    Institute of Biomedicine and Bioresources CNR Naples, Italy
    Cancer Biol Ther 15:735-41. 2014
  10. pmc Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans
    Manori Amarasekera
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
    FASEB J 28:4068-76. 2014

Research Grants

  1. Xiajun Li; Fiscal Year: 2014

Scientific Experts

  • Xiajun Li
  • D J G Mackay
  • Mads Bak
  • David Monk
  • I K Temple
  • Jeroen L A Pennings
  • Sabrina Spengler
  • Claire Vandiedonck
  • Daniel M Messerschmidt
  • Ho Tak Lau
  • Giovanna Grimaldi
  • Ruslan Strogantsev
  • Lizhi Liu
  • Vincenzo Riso
  • Zahra Anvar
  • Fong T Bell
  • Andrea Riccio
  • Ilaria Baglivo
  • Susanne E Boonen
  • Yiwei Liu
  • Angela Sparago
  • Marco Cammisa
  • Chelsea Ray
  • Carol M McDonald
  • Anne C Ferguson-Smith
  • Sachiko Takikawa
  • Paolo V Pedone
  • Robert Feil
  • Yan Wang
  • Harpreet Kukreja
  • Petr Volkov
  • Shinichiro Sano
  • Shraddha Lad
  • Hsiao P J Voon
  • Mikk Raba
  • Catherine Do
  • Claudia Angelini
  • Lijuan Xiao
  • Y Tada
  • Yulia Shamis
  • Nozomi Takahashi
  • Inna G Ovsyannikova
  • Tze Hau Lam
  • Xin Wang
  • Katharine Plant
  • Manori Amarasekera
  • C W Hanna
  • Alessandra Cirillo
  • Debora Dankert
  • Xin Ma
  • Yukari Yamaguchi
  • Dana E Cullen
  • Gaetano Verde
  • Mehmet Boyraz
  • Cansu Agca
  • Franck Court
  • Renuka P Dias
  • Ellen Anckaert
  • Bethany A Buck-Koehntop
  • Xiaodong Cheng
  • Johanne M D Hahnemann
  • Zeynep Tumer
  • Karen Grønskov
  • Xing Zhang
  • Seung Cheol Choi
  • Xiaopan Zuo
  • M Begemann
  • Simon Quenneville
  • Folami Y Ideraabdullah
  • Lene Bjerke Laborie
  • Adam E Handel
  • Ka Po Tse
  • Ryutaro Hirasawa
  • Yuin Han Loh
  • Maria B Duran Alonso
  • Angela M Christiano
  • Keiko Matsubara
  • Linn Gillberg
  • Izabela Krupska
  • Karl Fredrik Eriksson
  • Maria Lehtivaara
  • Qian Yang
  • Lynn Petukhova
  • Charlotte Brøns
  • Allan Vaag
  • Zhuojuan Luo
  • Flavia Cerrato
  • Wei Xie
  • Qian Dai
  • Chengqi Lin

Detail Information

Publications62

  1. ncbi Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system
    Maria B Duran Alonso
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 279:25653-64. 2004
    ..Zfp-57 mRNA is up-regulated in Schwann cells in response to leukemia inhibitory factor and fibroblast growth factor 2...
  2. pmc In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
    Simon Quenneville
    School of Life Sciences and Frontiers in Genetics Program, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Mol Cell 44:361-72. 2011
    ..Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of ..
  3. pmc A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints
    Xiajun Li
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:547-57. 2008
    ..We generated a knockout mouse in the Zfp57 locus encoding a KRAB zinc finger protein...
  4. doi Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57
    Deborah J G Mackay
    Division of Human Genetics, University of Southampton, Southampton SO16 6YD, UK
    Nat Genet 40:949-51. 2008
    ..We now report mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared ..
  5. ncbi A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation
    S Okazaki
    Department of Biochemistry, Kumamoto University School of Medicine, Japan
    J Biol Chem 269:6900-7. 1994
    ..Immunocytochemical analysis revealed that this protein is localized in the nucleus. These findings suggest that the Zfp-57 protein is a DNA-binding protein...
  6. ncbi A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron
    Yan Wang
    Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
    Nucleic Acids Res . 2016
    ..The localization of AFF3 to IG-DMR requires ZFP57. However, how AFF3 functions at the Meg3 enhancer in maintaining allele-specific gene expression remains unclear...
  7. pmc Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57
    Katharine Plant
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Hum Genet 22:568-71. 2014
    b>ZFP57 is an important transcriptional regulator involved in DNA methylation and genomic imprinting during development...
  8. doi The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells
    Y Tada
    Department of Stem Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan
    Oncogene 34:752-60. 2015
    ..The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell differentiation...
  9. pmc High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism
    Alessandra Cirillo
    Institute of Biomedicine and Bioresources CNR Naples, Italy
    Cancer Biol Ther 15:735-41. 2014
    ..We measured the mRNA levels of ZFP57, TRIM28, CPT1A, CPT1B, and CPT1C in a cohort of 80 patients divided in two groups: grade II and grade IV...
  10. pmc Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans
    Manori Amarasekera
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
    FASEB J 28:4068-76. 2014
    ..By far, the biggest effect observed was hypomethylation of a 923 bp region 3 kb upstream of the ZFP57 transcript, a regulator of DNA methylation during development, observed in both cell types...
  11. pmc The specification of imprints in mammals
    C W Hanna
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Heredity (Edinb) 113:176-83. 2014
    ..Among the factors involved in this selection, the zinc-finger protein Zfp57 can be regarded as an imprint-specific, sequence-specific DNA binding factor responsible for maintaining ..
  12. pmc Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes
    Debora Dankert
    Institute of Anatomy, University Hospital Essen, University Duisburg Essen, Essen, Germany
    PLoS ONE 9:e108907. 2014
    ..transcripts of in vitro-grown oocytes were deadenylated after 12 h of postovulatory aging (Tet3, Trim28, Zfp57, Dnmt1, Nlrp5, Zar1)...
  13. doi [The roles of maternal-effect proteins in the maintenance of genomic imprints]
    Xin Ma
    1 College of Animal Science and Technology, Key Laboratory of Animal Production and Production Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China 2 College of Veterinary Medicine, Jilin University, Changchun 130062, China
    Yi Chuan 36:959-64. 2014
    ..in the maintenance of genomic imprints, the recent study progress of maternal-effect proteins, such as DPPA3, ZFP57, TRIM28 and DNMT1, are summarized, and the regulation mechanism of these maternal-effect proteins for genomic ..
  14. doi Nanog positively regulates Zfp57 expression in mouse embryonic stem cells
    Yukari Yamaguchi
    Department of Gastroenterologic Surgery, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan
    Biochem Biophys Res Commun 453:817-20. 2014
    ..Zinc finger protein 57 (Zfp57) is specifically expressed in self-renewing ES cells and its expression level is reduced upon ES cell ..
  15. pmc Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development
    Yulia Shamis
    Department of Developmental and Regenerative Biology, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    Proc Natl Acad Sci U S A 112:E2020-9. 2015
    b>Zfp57 is a maternal-zygotic effect gene that maintains genomic imprinting...
  16. doi Germline-derived DNA methylation and early embryo epigenetic reprogramming: The selected survival of imprints
    David Monk
    Imprinting and Cancer Group, Cancer Epigenetic and Biology Program, Institut d Investigacio Biomedica de Bellvitge, Hospital Duran i Reynals, Barcelona 08908, Spain Electronic address
    Int J Biochem Cell Biol 67:128-38. 2015
    ..This suggests that trans-acting factors such as Zfp57 can discriminate imprinted differentially methylated regions (DMRs) from the thousands of CpG rich regions that ..
  17. pmc Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression
    Ruslan Strogantsev
    Department of Physiology Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, CB2 3EG, UK
    Genome Biol 16:112. 2015
    ..The Kruppel-like zinc finger protein ZFP57 acts as a factor necessary for maintaining the DNA methylation memory at multiple imprinting control regions in ..
  18. pmc Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells
    Sachiko Takikawa
    Black Family Stem Cell Institute Department of Developmental and Regenerative Biology Department of Oncological Sciences Graduate School of Biological Sciences Icahn School of Medicine at Mount Sinai New York, NY USA
    Epigenetics 8:1268-79. 2013
    ..Dysregulation of genomic imprinting has been implicated in a variety of human diseases. ZFP57 is a master regulator in genomic imprinting...
  19. pmc Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 1st Street S W, Rochester, Minnesota, 55905, USA
    Immunogenetics 67:547-61. 2015
    ..gene, one in the TRIM22 gene, two in the IL10RB gene, two in the TLR4 gene, and five in other genes (PVR, ADAR, ZFP57, MX1, and BTN2A1/BTN3A3)...
  20. pmc ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells
    Zahra Anvar
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, 80131 Naples, Italy Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, 81100 Caserta, Italy
    Nucleic Acids Res 44:1118-32. 2016
    ..b>ZFP57 and KAP1 are both required for maintaining the repressive DNA methylation and H3-lysine-9-trimethylation (H3K9me3) ..
  21. pmc Intrahaplotypic Variants Differentiate Complex Linkage Disequilibrium within Human MHC Haplotypes
    Tze Hau Lam
    Singapore Immunology Network, A STAR, 8A Biomedical Grove, 03 06 Immunos, Singapore 138648, Singapore
    Sci Rep 5:16972. 2015
    ..can be resolved using intra-CEH variants, as evidenced by rs3129063 and rs448489, which affect expression of ZFP57, a gene important in methylation and epigenetic regulation...
  22. pmc Maintaining memory of silencing at imprinted differentially methylated regions
    Hsiao P J Voon
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic, 3800, Australia
    Cell Mol Life Sci 73:1871-9. 2016
    ..for protecting the epigenetic modifications at imprinted differentially methylated regions (DMRs), including PGC7, ZFP57 and the ATRX/Daxx/H3.3 complex...
  23. pmc Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons
    Mikk Raba
    Department of Gene Technology, Tallinn University of Technology Tallinn, Estonia
    Front Cell Neurosci 10:66. 2016
    ..As an example, we studied the changes in the expression of selected genes Igf2bp3, Coro1A, Zfp57, Dcx, and Apaf1 in the young and mature sympathetic ganglia by quantitative PCR and show that these were strongly ..
  24. pmc Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57
    Mads Bak
    Wilhelm Johannsen Center for Functional Genome Research, Institute of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, DK 2200, Copenhagen N, Denmark
    BMC Med Genet 17:29. 2016
    Transient neonatal diabetes mellitus 1 (TNDM1) is a rare imprinting disorder characterized by intrautering growth retardation and diabetes mellitus usually presenting within the first six weeks of life and resolves by the age of 18 ..
  25. doi Beckwith-Wiedemann syndrome and pseudohypoparathyroidism type Ib in a patient with multilocus imprinting disturbance: a female-dominant phenomenon?
    Shinichiro Sano
    Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Hum Genet 61:765-9. 2016
    ..MDs) at the Kv-DMR and the GNAS-DMRs and variable MDs at four additional DMRs, in the absence of a mutation in ZFP57, NLRP2, NLRP7, KHDC3L and NLRP5...
  26. pmc Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation
    Catherine Do
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA Electronic address
    Am J Hum Genet 98:934-55. 2016
    ..with neurological disorders, NGFR and HLA-DRB6, associated with both immunological and brain disorders, and ZFP57, a trans-acting regulator of genomic imprinting...
  27. pmc Genomic imprinting defect in Zfp57 mutant iPS cell lines
    Carol M McDonald
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:259-63. 2016
    b>ZFP57 maintains genomic imprinting in mouse embryos and ES cells. To test its roles during iPS reprogramming,we derived iPS clones by utilizing retroviral infection to express reprogramming factors in mouse MEF cells...
  28. pmc ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells
    Vincenzo Riso
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, 80131 Naples, Italy Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, 81100 Caserta, Italy
    Nucleic Acids Res 44:8165-78. 2016
    b>ZFP57 is necessary for maintaining repressive epigenetic modifications at Imprinting control regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICRBS) and many other loci (non-ICRBS)...
  29. pmc Derivation of hybrid ES cell lines from two different strains of mice
    Ho Tak Lau
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:252-5. 2016
    Parental origin-dependent expression of the imprinted genes is essential for mammalian development. Zfp57 maintains genomic imprinting in mouse embryos and ES cells...
  30. pmc A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits
    Petr Volkov
    Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Malmo, Sweden
    PLoS ONE 11:e0157776. 2016
    ..associated with expression of 86 genes in adipose tissue including CHRNA5, G6PC2, GPX7, RPL27A, THNSL2 and ZFP57. SNPs in significant mQTLs were also associated with body mass index (BMI), lipid traits and glucose and insulin ..
  31. doi ZFP57 and the Targeted Maintenance of Postfertilization Genomic Imprints
    Nozomi Takahashi
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Cold Spring Harb Symp Quant Biol 80:177-87. 2015
    ..Krüppel-associated box zinc finger proteins (KRAB-ZFPs) are proteins that have the potential to mediate this. ZFP57, one of the best characterized proteins in this family, has been shown to target and maintain epigenetic states at ..
  32. pmc Zfp57 mutant ES cell lines directly derived from blastocysts
    Ho Tak Lau
    Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:282-6. 2016
    b>Zfp57 is a master regulator of genomic imprinting in mouse embryos. To further test its functions, we have derived multiple Zfp57 mutant ES clones directly from mouse blastocysts...
  33. doi Dynamics of imprinted DNA methylation and gene transcription for imprinting establishment in mouse oocytes in relation to culture duration variability
    Ellen Anckaert
    Follicle Biology Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
    Biol Reprod 89:130. 2013
    ..for genes previously shown to be essential for imprinting establishment in oocytes, including Dnmt3a, Dnmt3L, and Zfp57. Oocyte total mRNA levels during in vitro follicle culture showed the timely shutdown in transcription at the ..
  34. doi Genes, assisted reproductive technology and trans-illumination
    Renuka P Dias
    Centre for Rare Diseases and Personalised Medicine, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Epigenomics 5:331-40. 2013
    ..g., mutations in KHDC3L [C6ORF221], NLRP2 [NALP2], NLRP7 [NALP7] and ZFP57) and environmental (assisted reproductive technologies) factors that can disturb the normal trans mechanisms for ..
  35. doi Nanog regulates molecules involved in stemness and cell cycle-signaling pathway for maintenance of pluripotency of P19 embryonal carcinoma stem cells
    Seung Cheol Choi
    Cardiovascular Center, Department of Cardiology, Korea University Anam Hospital, Seoul, Republic of Korea
    J Cell Physiol 227:3678-92. 2012
    ..However, expressions of pluripotency markers Cripto, germ cell nuclear factor, Sox2, and Zfp57 as well as leukemia inhibitory factor (LIF)/Stat3 pathway molecules LIF, IL6st, and Stat3 were not affected after ..
  36. doi Proteins involved in establishment and maintenance of imprinted methylation marks
    Ruslan Strogantsev
    Department of Physiology Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, CB2 3EG, UK
    Brief Funct Genomics 11:227-39. 2012
    ..Specifically, we discuss the recent findings of a critical role played by a KRAB zinc-finger protein ZFP57 and its co-factor KAP1/TRIM28 in mediating both processes.
  37. pmc Should I stay or should I go: protection and maintenance of DNA methylation at imprinted genes
    Daniel M Messerschmidt
    Mammalian Development Group, Institute of Medical Biology, Singapore
    Epigenetics 7:969-75. 2012
    ..in preimplantation embryos have been identified, in particular, an epigenetic modifier complex formed by ZFP57 and TRIM28/KAP1...
  38. pmc An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence
    Yiwei Liu
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Genes Dev 26:2374-9. 2012
    Zinc finger transcription factor Zfp57 recognizes the methylated CpG within the TGCCGC element...
  39. pmc Transient neonatal diabetes, ZFP57, and hypomethylation of multiple imprinted loci: a detailed follow-up
    Susanne E Boonen
    Center for Applied Human Molecular Genetics, The Kennedy Center, Glostrup, Denmark
    Diabetes Care 36:505-12. 2013
    Transient neonatal diabetes mellitus 1 (TNDM1) is the most common cause of diabetes presenting at birth...
  40. doi Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes
    Cansu Agca
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Mol Reprod Dev 80:102-17. 2013
    ..Ccnb1ip1, and Zp3); maternal effect genes required for embryo development (Zar1, Npm2, Nlrp5, Dnmt1, H1foo, and Zfp57); amino acid degradation; and ketogenesis (Hmgcs2, and Cpt1b)...
  41. doi Genomic imprinting is a parental effect established in mammalian germ cells
    Xiajun Li
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
    Curr Top Dev Biol 102:35-59. 2013
    ..Maintenance of the DNA methylation imprint is dependent on two distinct maternal effect genes (Zfp57 and PGC7/Stella)...
  42. pmc On how mammalian transcription factors recognize methylated DNA
    Bethany A Buck-Koehntop
    Department of Chemistry, University of Utah, Salt Lake City, UT, USA
    Epigenetics 8:131-7. 2013
    ..puzzle has been recently revealed by the structural resolution of two different zinc finger proteins, Kaiso and ZFP57, in complex with methylated DNA...
  43. doi Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes
    Franck Court
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Hum Mutat 34:595-602. 2013
    ..A mutation analysis identified a 1 bp deletion in the ZFP57 gene in a TNDM patient with methylation defects at multiple maternal DMRs...
  44. pmc DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å
    Yiwei Liu
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, United States
    Biochemistry 52:9310-7. 2013
    The Zfp57 gene encodes a KRAB (Krüppel-associated box) domain-containing C2H2 zinc finger transcription factor that is expressed in early development...
  45. pmc Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1
    Ilaria Baglivo
    Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    FEBS Lett 587:1474-81. 2013
    In the mouse, ZFP57 contains three classical Cys2His2 zinc finger domains (ZF) and recognizes the methylated TGC(met)CGC target sequence using the first and the second ZFs...
  46. pmc Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene
    Mehmet Boyraz
    Sisli Etfal Education and Research Hospital, Division of Pediatric Endocrinology, Istanbul, Turkey
    J Clin Res Pediatr Endocrinol 5:125-8. 2013
    ..patient with NDM caused by a loss of methylation at chromosome 6q24 and three novel homozygous mutations in the ZFP57 gene, methylation-specific PCR was carried out at 6q24 and mutation analysis of ZFP57 gene was maintained by ..
  47. pmc Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
    Yuin Han Loh
    Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672
    Genes Dev 21:2545-57. 2007
    ..Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes...
  48. doi A KRAB domain zinc finger protein in imprinting and disease
    Ryutaro Hirasawa
    Institute of Molecular Genetics, CNRS and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
    Dev Cell 15:487-8. 2008
    ..Li et al. (2008) show in this issue of Developmental Cell that the KRAB zinc finger protein Zfp57 contributes to the embryonic maintenance of these imprints...
  49. doi DNA hypomethylation, transient neonatal diabetes, and prune belly sequence in one of two identical twins
    Lene Bjerke Laborie
    Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway
    Eur J Pediatr 169:207-13. 2010
    ..Microsatellite marker analysis confirmed the twins being monozygotic. We identified no mutations in ZFP57, KCNJ11, ABCC8, GCK, HNF1A, HNF1B, HNF3B, IPF1, PAX4, or ZIC3...
  50. doi Screening for genomic variants in ZFP57 in Silver-Russell syndrome patients with 11p15 epimutations
    Sabrina Spengler
    Institute of Human Genetics, RWTH Aachen, Germany
    Eur J Med Genet 52:415-6. 2009
    ..In >38% of SRS cases a hypomethylation of the H19/IGF2 DMR in 11p15 can be detected. Recently, ZFP57 mutations have been identified as a cause of hypomethylation of multiple imprinted loci...
  51. doi Extending the maternal-zygotic effect with genomic imprinting
    Xiajun Li
    Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Hum Reprod 16:695-703. 2010
    ..The molecular mechanisms underlying genomic imprinting are poorly understood. Mouse Zfp57 is the first example of a mammalian maternal-zygotic effect gene and it exhibits maternal-zygotic embryonic ..
  52. pmc The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10142. 2010
    ..We investigated whether these genetic variations were associated with alteration in gene expression...
  53. doi Identification by gene coregulation mapping of novel genes involved in embryonic stem cell differentiation
    Jeroen L A Pennings
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Stem Cells Dev 20:115-26. 2011
    ..For 6 of these genes (Apobec2, Cth, Ptges, Rrad, Zfp57, and 2410146L05Rik), literature data on mouse knockout phenotypes support their putative function...
  54. doi Silver-Russell patients showing a broad range of ICR1 and ICR2 hypomethylation in different tissues
    M Begemann
    Institute of Human Genetics, RWTH, Aachen, Germany
    Clin Genet 80:83-8. 2011
    ..mutation screening of several factors involved in establishment and maintenance of methylation marks including ZFP57, MBD3, DNMT1 and DNMT3L the molecular clue for the ICR1/ICR2 hypomethylation in our patients remained unclear...
  55. doi Transient neonatal diabetes mellitus type 1
    Deborah J G Mackay
    University of Southampton, UK
    Am J Med Genet C Semin Med Genet 154:335-42. 2010
    Transient neonatal diabetes mellitus type 1 (TNDM1) is a rare but remarkable form of diabetes which presents in infancy, resolves in the first months of life, but then frequently recurs in later life...
  56. doi 6q24 transient neonatal diabetes
    I Karen Temple
    Academic Unit of Genetic Medicine, Princess Anne Hospital, Coxford Road, Southampton, SO16 5YA, UK
    Rev Endocr Metab Disord 11:199-204. 2010
    ..In some individuals, diabetes may be the initial presentation of a more complex imprinting disorder due to recessive mutations in the gene ZFP57 and may be associated with other developmental problems.
  57. pmc Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex
    Claire Vandiedonck
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Genome Res 21:1042-54. 2011
    ..4%), most significantly the zing finger protein gene ZFP57. Differentially expressed probes are correlated with polymorphisms between haplotypes, consistent with cis effects ..
  58. pmc No evidence for pathogenic variants or maternal effect of ZFP57 as the cause of Beckwith-Wiedemann Syndrome
    Susanne E Boonen
    Center for Applied Human Molecular Genetics, The Kennedy Center, Glostrup, Denmark
    Eur J Hum Genet 20:119-21. 2012
    ..5. The underlying defect of this hypomethylation is largely unknown. Recently, recessive mutations of the ZFP57 gene were reported in patients with transient neonatal diabetes mellitus type 1, showing hypomethylation at ..
  59. ncbi ZFP57: KAPturing DNA Methylation at Imprinted Loci
    Folami Y Ideraabdullah
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell 44:341-2. 2011
    In this issue of Molecular Cell, Quenneville et al. (2011) characterize the role of ZFP57 in the maintenance of DNA methylation at imprinting control regions (ICRs), revealing an allele-specific binding pattern, binding motif, and ..
  60. pmc Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain
    Xiaopan Zuo
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:2107-18. 2012
    Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation genomic imprint at multiple imprinted regions in mouse embryos...
  61. pmc Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3
    Ka Po Tse
    Genomic Medicine Core, Chang Gung Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Am J Hum Genet 85:194-203. 2009
    ..3 are associated with NPC. Although some of these relationships may be attributed to linkage disequilibrium between the loci, the findings clearly provide a fresh direction for the study of NPC development...

Research Grants1

  1. Xiajun Li; Fiscal Year: 2014
    ..Our preliminary results indicate that ZFP57 appears to be required for cardiovascular development...