ZCWPW1

Summary

Gene Symbol: ZCWPW1
Description: zinc finger CW-type and PWWP domain containing 1
Alias: ZCW1, zinc finger CW-type PWWP domain protein 1, zinc finger CW-type and PWWP domain 1, zinc finger, CW-type with PWWP domain 1
Species: human

Top Publications

  1. pmc Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways
    Mark W Logue
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Neurobiol Aging 35:1510.e7-18. 2014
  2. pmc Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings
    Samantha L Rosenthal
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e95152. 2014
  3. pmc Alzheimer's disease risk genes and mechanisms of disease pathogenesis
    Celeste M Karch
    Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri
    Biol Psychiatry 77:43-51. 2015
  4. pmc Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
    Gary W Beecham
    John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America
    PLoS Genet 10:e1004606. 2014
  5. doi Genetics of Alzheimer's disease
    Vincent Chouraki
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA Framingham Heart Study, Framingham, MA, USA
    Adv Genet 87:245-94. 2014
  6. pmc Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci
    Crystal Humphries
    John P Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA Dr John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Mol Cell Neurosci 67:37-45. 2015
  7. pmc Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci
    Celeste M Karch
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 11:e0148717. 2016
  8. pmc Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins
    Yanli Liu
    From the Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada, the Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, China
    J Biol Chem 291:9000-13. 2016
  9. pmc ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses
    Yu Gao
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China
    Oncotarget 7:20305-11. 2016
  10. pmc Gene-based aggregate SNP associations between candidate AD genes and cognitive decline
    Jasmine Nettiksimmons
    Department of Psychiatry, University of San Francisco California, 4150 Clement Street, Box VAMC 116H, San Francisco, CA, 94121, USA
    Age (Dordr) 38:41. 2016

Scientific Experts

  • Jasmine Nettiksimmons
  • Celeste M Karch
  • Yu Gao
  • Yanli Liu
  • Gennady V Roshchupkin
  • Jan Bressler
  • Alison M Goate
  • Crystal Humphries
  • Margaret A Pericak-Vance
  • Deborah C Mash
  • Gary W Beecham
  • Samantha L Rosenthal
  • Lindsay A Farrer
  • Mark W Logue
  • M Ilyas Kamboh
  • Vincent Chouraki
  • Fahu He
  • Mohammad A Ikram
  • Lubov A Ezerskiy
  • Peter Loppnau
  • Xiao Liang
  • Andre G Uitterlinden
  • Teng Jiang
  • Sven J van der Lee
  • Cornelia M van Duijn
  • Beverly Gwen Windham
  • Albert Hofman
  • David S Knopman
  • Jason Perry
  • Rebecca F Gottesman
  • Zi xuan Wang
  • Wolfram Tempel
  • Lisa M Wruck
  • Lan Tan
  • Jinrong Min
  • Hieab H Adams
  • Alan Penman
  • Jin Tai Yu
  • Wiro J Niessen
  • Eric Boerwinkle
  • Su Qin
  • Qi Zhang
  • Thomas H Mosley
  • Aad van der Lugt
  • Wei Zhang
  • Sarah Bertelsen
  • Hui Fu Wang
  • Meng Shan Tan
  • Meike W Vernooij
  • Patrice Whitehead
  • Martin A Kohli
  • John Gilbert
  • Badri N Vardarajan
  • M Michael Barmada
  • Jonathan L Haines
  • Kathryn L Lunetta
  • John Farrell
  • Philip L De Jager
  • Kara Hamilton
  • Matt Huentelman
  • Linda Duque
  • Clinton T Baldwin
  • Matthew Schu
  • Sudha Seshadri
  • Bernardino Ghetti
  • Gerard D Schellenberg
  • Bradley T Hyman
  • Joseph D Buxbaum
  • Jean Paul Vonsattel
  • Dennis W Dickson
  • Xingbin Wang
  • Eric B Larson
  • Steven G Younkin
  • Richard P Mayeux
  • Jason J Corneveaux
  • John R Gilbert
  • Margaret M DeAngelis
  • John Q Trojanowski
  • Julie A Schneider
  • David A Bennett
  • Thomas J Montine
  • Julia K Kofler
  • Gyungah Jun
  • Eric M Reiman
  • Eden R Martin
  • Walter A Kukull
  • Paul K Crane
  • Harry Gwirtsman
  • John Hardy
  • F Yesim Demirci

Detail Information

Publications14

  1. pmc Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways
    Mark W Logue
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Neurobiol Aging 35:1510.e7-18. 2014
    ..We observed association of both disorders with genes in a region of chromosome 7, including PILRA and ZCWPW1 (peak AMD SNP rs7792525, minor allele frequency [MAF] = 19%, odds ratio [OR] = 1.14, p = 2...
  2. pmc Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings
    Samantha L Rosenthal
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e95152. 2014
    ..evidence of regulatory function (RegulomeDB score <3), and only 3 of them were genome-wide significant SNPs (ZCWPW1/rs1476679, CLU/rs1532278 and ABCA7/rs3764650)...
  3. pmc Alzheimer's disease risk genes and mechanisms of disease pathogenesis
    Celeste M Karch
    Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri
    Biol Psychiatry 77:43-51. 2015
    ..CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-DBR1, INPP5D, MS4A, MEF2C, NME8, PICALM, PTK2B, SLC24H4-RIN3, SORL1, and ZCWPW1. Emerging technologies to analyze the entire genome in large data sets have also revealed coding variants that ..
  4. pmc Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
    Gary W Beecham
    John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America
    PLoS Genet 10:e1004606. 2014
    ..were confirmed in our clinico-pathologic sample: CR1, BIN1, CLU, MS4A6A, PICALM, ABCA7, CD33, PTK2B, SORL1, MEF2C, ZCWPW1, and CASS4 with 9 of these 12 loci showing larger odds ratio in the clinico-pathologic sample...
  5. doi Genetics of Alzheimer's disease
    Vincent Chouraki
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA Framingham Heart Study, Framingham, MA, USA
    Adv Genet 87:245-94. 2014
    ..PICALM), CD33, EPHA1, MS4A4/MS4A6, ABCA7, CD2AP, SORL1, HLA-DRB5/DRB1, PTK2B, SLC24A4-RIN3, INPP5D, MEF2C, NME8, ZCWPW1, CELF1, FERMT2, CASS4, and TRIP4 and each has small effects on risk of AD (relative risks of 1.1-1.3)...
  6. pmc Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci
    Crystal Humphries
    John P Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA Dr John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Mol Cell Neurosci 67:37-45. 2015
    ..Eight loci, prominently ABCA7, contain LOAD specific differences. Significant changes in the CELF1 and ZCWPW1 loci occurred in genes not located nearest the associated variant, suggesting that these genes should be ..
  7. pmc Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci
    Celeste M Karch
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 11:e0148717. 2016
    ..We found a significant eQTL between rs1476679 and PILRB and GATS, which occurs within the ZCWPW1 locus. PILRB and GATS expression levels, within the ZCWPW1 locus, were also associated with AD status...
  8. pmc Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins
    Yanli Liu
    From the Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada, the Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, China
    J Biol Chem 291:9000-13. 2016
    ..that the CW domains in ZCWPW2 and MORC3/4 selectively recognize histone H3 trimethylated at Lys-4, similar to ZCWPW1 reported previously, while the MORC1/2 and LSD2 lack histone H3 Lys-4 binding ability...
  9. pmc ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses
    Yu Gao
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China
    Oncotarget 7:20305-11. 2016
    Recently, a large genome-wide association study (GWAS) has identified a novel variant (rs1476679) within ZCWPW1 showing strong association with late-onset Alzheimer's disease (LOAD) in Caucasian...
  10. pmc Gene-based aggregate SNP associations between candidate AD genes and cognitive decline
    Jasmine Nettiksimmons
    Department of Psychiatry, University of San Francisco California, 4150 Clement Street, Box VAMC 116H, San Francisco, CA, 94121, USA
    Age (Dordr) 38:41. 2016
    ..HLA cluster (DRB5-DQA), INPP5D, MEF2C, MS4A cluster (MS4A3-MS4A6E), NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1 have been associated with Alzheimer's disease (AD) in large meta-analyses...
  11. doi Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology
    Gennady V Roshchupkin
    Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neurobiol Aging 48:204-211. 2016
    ..45 × 10-6), right superior frontal gyrus by ZCWPW1 (rs1476679, p = 5.12 × 10-6), and right postcentral gyrus by APOE (p = 6.91 × 10-6)...
  12. doi Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study
    Jan Bressler
    Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas
    Am J Med Genet B Neuropsychiatr Genet . 2016
    ..The ZCWPW1 (rs1476679) and CDS33 (rs3865444) variants were nominally associated with change on the DWRT and WFT in African-..
  13. ncbi The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants
    Jason Perry
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Trends Biochem Sci 28:576-80. 2003
    ..However, several families contain other domains suggesting a relationship between the CW domain and either chromatin methylation status or early embryonic development...
  14. doi Structural insight into the zinc finger CW domain as a histone modification reader
    Fahu He
    RIKEN Systems and Structural Biology Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Structure 18:1127-39. 2010
    ..determined the NMR solution structure of the zf-CW domain of the human zf-CW and PWWP domain containing protein 1 (ZCWPW1)...