ZBTB21

Summary

Gene Symbol: ZBTB21
Description: zinc finger and BTB domain containing 21
Alias: ZNF295, zinc finger and BTB domain-containing protein 21, zinc finger protein 295
Species: human

Top Publications

  1. doi Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif
    Ivan Matic
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried D 82152, Germany
    Mol Cell 39:641-52. 2010
  2. pmc Nucleosome-interacting proteins regulated by DNA and histone methylation
    Till Bartke
    The Gurdon Institute, Department of Pathology, Cambridge, UK
    Cell 143:470-84. 2010
  3. pmc Genetics of hand grip strength in mid to late life
    Jessica P L Chan
    Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales UNSW, NPI, Euroa Centre, Barker St, Randwick, Sydney, NSW, 2031, Australia
    Age (Dordr) 37:9745. 2015
  4. ncbi Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Hum Mol Genet 13:1333-40. 2004
  5. doi Expression of trisomic proteins in Down syndrome model systems
    Claire Spellman
    Department of Pediatrics, Linda Crnic Institute for Down Syndrome, Intellectual and Developmental Disabilities Research Center, University of Colorado Denver School of Medicine, 12700 E 19th Avenue, Mail Stop 8608, Aurora, CO 80045, USA
    Gene 512:219-25. 2013
  6. pmc The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome
    M Reza Sailani
    Department of Genetic Medicine and Development, University of Geneva, Geneva 1211, Switzerland
    Genome Res 23:1410-21. 2013
  7. ncbi Evolutionary breakpoints on human chromosome 21
    M T Davisson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 78:99-106. 2001
  8. ncbi Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161
    Jun Wang
    Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 327:615-27. 2005
  9. doi Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain
    N Ramakrishna
    Molecular Biology Department, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neuroscience 161:451-8. 2009

Scientific Experts

  • Claire Spellman
  • Muriel Davisson
  • N Ramakrishna
  • Jessica P L Chan
  • M Reza Sailani
  • Ivan Matic
  • Matthias Mann
  • Till Bartke
  • Jun Wang
  • Kenji Amano
  • Jasmine Menant
  • Mark McEvoy
  • Perminder S Sachdev
  • John B Kwok
  • Henry Brodaty
  • Christopher Oldmeadow
  • Amelia A Assareh
  • Peter R Schofield
  • Stephen J Hancock
  • Karen A Mather
  • Rodney J Scott
  • John R Attia
  • Anbupalam Thalamuthu
  • Rosanne Peel
  • Nicola J Armstrong
  • Simone Reppermund
  • Elizabeth G Holliday
  • Julian N Trollor
  • Giuseppe Merla
  • Kelly Rabionet
  • Eugenia Migliavacca
  • Andrew J Sharp
  • Christelle Borel
  • Samuel Deutsch
  • Daniela Laux
  • Genevieve Duriaux Sail
  • Clara Serra-Juhé
  • Stefano Vicari
  • Yann Grattau
  • Guy Dembour
  • Emmanouel Kanavakis
  • Damien Bonnet
  • Xavier Estivill
  • Chariklia Chatzisevastou-Loukidou
  • Andre Megarbane
  • Periklis Makrythanasis
  • Sofia Kitsiou
  • Jean M Delabar
  • Helena Fryssira
  • Renaud Touraine
  • Stylianos E Antonarakis
  • Armand Valsesia
  • Emilie Falconnet
  • Konstantin Popadin
  • Federico A Santoni
  • Luis A Pérez-Jurado
  • Samantha Stora
  • Alfred C O Vertegaal
  • Florian Gnad
  • Blerta Xhemalce
  • Hans van Dam
  • Frans van de Rijke
  • Samuel C Robson
  • Ivo A Hendriks
  • Maria A van Santen
  • Michiel Vermeulen
  • Tony Kouzarides
  • Joost Schimmel
  • Nobuyoshi Shimizu
  • Jun Kudoh
  • Atsushi Takayanagi
  • Svetlana E Kotliarova
  • Haruhiko Sago
  • Charles J Epstein
  • Taishi Suzuki
  • Nobuyuki Nukina
  • Chiharu Uchikawa
  • Kazuhiro Yamakawa

Detail Information

Publications9

  1. doi Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif
    Ivan Matic
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried D 82152, Germany
    Mol Cell 39:641-52. 2010
    ..In 16 proteins we identified a hydrophobic cluster SUMOylation motif (HCSM). SUMO conjugation of RanGAP1 and ZBTB1 via HCSMs is remarkably efficient...
  2. pmc Nucleosome-interacting proteins regulated by DNA and histone methylation
    Till Bartke
    The Gurdon Institute, Department of Pathology, Cambridge, UK
    Cell 143:470-84. 2010
    ....
  3. pmc Genetics of hand grip strength in mid to late life
    Jessica P L Chan
    Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales UNSW, NPI, Euroa Centre, Barker St, Randwick, Sydney, NSW, 2031, Australia
    Age (Dordr) 37:9745. 2015
    ..Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS...
  4. ncbi Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Hum Mol Genet 13:1333-40. 2004
    ..and has a segmental trisomy of chromosome 16 orthologous to a segment of human chromosome 21 spanning from Sod1 to Znf295. DNA microarray analyses of six Ts1Cje and six normal littermate (2N) mouse brains at postnatal day 0 with probe ..
  5. doi Expression of trisomic proteins in Down syndrome model systems
    Claire Spellman
    Department of Pediatrics, Linda Crnic Institute for Down Syndrome, Intellectual and Developmental Disabilities Research Center, University of Colorado Denver School of Medicine, 12700 E 19th Avenue, Mail Stop 8608, Aurora, CO 80045, USA
    Gene 512:219-25. 2013
    ..Genes for 12 of these proteins are trisomic in the Tc1 mouse model of DS, but only SIM2 and ZNF295 showed elevated expression in Tc1 cortex when compared with controls...
  6. pmc The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome
    M Reza Sailani
    Department of Genetic Medicine and Development, University of Geneva, Geneva 1211, Switzerland
    Genome Res 23:1410-21. 2013
    ..05). One of these CNVs maps near the RIPK4 gene, and the second includes the ZBTB21 (previously ZNF295) gene, highlighting the potential role of these genes in the pathogenesis of CHD in DS...
  7. ncbi Evolutionary breakpoints on human chromosome 21
    M T Davisson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 78:99-106. 2001
    ..The mouse chromosome 16/chromosome 17 evolutionary breakpoint is between human genes ZNF295 and UMODL1, showing there are seven genes in the chromosome 16 segment distal to Tmprss2...
  8. ncbi Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161
    Jun Wang
    Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 327:615-27. 2005
    Human ZNF295 protein harbors a BTB/POZ domain and multiple krüppel (C(2)H(2)) type zinc finger domains, and thus belongs to a family of POK (POZ and krüppel) transcription factor...
  9. doi Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain
    N Ramakrishna
    Molecular Biology Department, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neuroscience 161:451-8. 2009
    ..syntenic with Hsa 21 whose expression is affected by the presence of three copies of genes between loci Mrpl39 and Znf295 on mouse chromosome 16 (Mmu 16)...