ZBTB1

Summary

Gene Symbol: ZBTB1
Description: zinc finger and BTB domain containing 1
Alias: ZNF909, zinc finger and BTB domain-containing protein 1
Species: human

Top Publications

  1. ncbi Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer
    Joseph Petroziello
    Department of Antibody Technologies, Seattle Genetics Inc, 21823 30th Drive SE, Bothell, WA 98021, USA
    Oncogene 23:7734-45. 2004
  2. pmc Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis
    Hyungjin Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Mol Cell 54:107-18. 2014
  3. doi EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300
    Wei Wei Zheng
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Stem Cells 32:2278-89. 2014
  4. pmc Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors
    Xin Cao
    College of Life Science and Engineering, Northwest University for Nationalities, Lanzhou 730030, China and Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Immunol 197:1199-211. 2016
  5. pmc Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors
    Xianyu Zhang
    Experimental Immunology Branch, NCI, NIH, Maryland, USA
    Oncotarget 7:58768-58778. 2016
  6. ncbi A proteomic study of SUMO-2 target proteins
    Alfred C O Vertegaal
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 279:33791-8. 2004
  7. pmc Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells
    Zhuowei Li
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Health Perspect 113:1747-54. 2005
  8. pmc Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development
    Divya Punwani
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 91413, USA
    J Immunol 189:1253-64. 2012
  9. doi Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression
    Dennis J van de Wijngaart
    Department of Urology, Josephine Nefkens Institute, Erasmus Medical College, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Endocrinol 23:1776-86. 2009
  10. doi Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif
    Ivan Matic
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried D 82152, Germany
    Mol Cell 39:641-52. 2010

Research Grants

  1. Jennifer M Puck; Fiscal Year: 2014

Detail Information

Publications12

  1. ncbi Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer
    Joseph Petroziello
    Department of Antibody Technologies, Seattle Genetics Inc, 21823 30th Drive SE, Bothell, WA 98021, USA
    Oncogene 23:7734-45. 2004
    ..Follow-up studies for candidate NSCLC-associated genes can be useful in providing valuable insight into the etiology of lung cancer as well as providing potentially interesting diagnostic or therapeutic targets for further investigation...
  2. pmc Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis
    Hyungjin Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Mol Cell 54:107-18. 2014
    ..Here, we show that the UBZ4 domain-containing transcriptional repressor ZBTB1 is a critical upstream regulator of TLS...
  3. doi EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300
    Wei Wei Zheng
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Stem Cells 32:2278-89. 2014
    ..Microarray analysis suggested that EDAG knockdown selectively inhibits GATA1-activated target genes. These data provide novel insights into EDAG in regulation of erythroid differentiation...
  4. pmc Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors
    Xin Cao
    College of Life Science and Engineering, Northwest University for Nationalities, Lanzhou 730030, China and Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Immunol 197:1199-211. 2016
    Expression of the transcription factor Zbtb1 is required for normal lymphoid development...
  5. pmc Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors
    Xianyu Zhang
    Experimental Immunology Branch, NCI, NIH, Maryland, USA
    Oncotarget 7:58768-58778. 2016
    b>Zbtb1 is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone ..
  6. ncbi A proteomic study of SUMO-2 target proteins
    Alfred C O Vertegaal
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 279:33791-8. 2004
    ..SART1 and heterogeneous nuclear RNP M were both shown to be genuine SUMO targets, confirming the validity of the approach...
  7. pmc Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells
    Zhuowei Li
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Health Perspect 113:1747-54. 2005
    ..Cluster 1 genes (ZBTB1, PML, ZNF44, SIX1, BCL6, ZNF450) were down-regulated by V and involved in gene transcription, whereas cluster 2 ..
  8. pmc Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development
    Divya Punwani
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 91413, USA
    J Immunol 189:1253-64. 2012
    ..using bacterial artificial chromosome transgenesis implicated zinc finger BTB-POZ domain protein 1 (Zbtb1) in the immunodeficiency, confirming its role in T cell development and suggesting involvement in B and NK cell ..
  9. doi Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression
    Dennis J van de Wijngaart
    Department of Urology, Josephine Nefkens Institute, Erasmus Medical College, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Endocrinol 23:1776-86. 2009
    ..In summary, our data demonstrate that BAF60a directly interacts with the coactivator groove in the AR ligand-binding domain via its FxxFF motif, thereby selectively activating specific AR-driven promoters...
  10. doi Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif
    Ivan Matic
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried D 82152, Germany
    Mol Cell 39:641-52. 2010
    ..In 16 proteins we identified a hydrophobic cluster SUMOylation motif (HCSM). SUMO conjugation of RanGAP1 and ZBTB1 via HCSMs is remarkably efficient.
  11. doi Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE
    Qingmei Liu
    Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou 215123, China
    Mol Cell Biochem 357:405-14. 2011
    ..Here, we characterized the member of C(2)H(2) type zinc finger gene, Zinc finger and BTB domain containing 1 (ZBTB1)...
  12. pmc ZBTB1 is a determinant of lymphoid development
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 209:19-27. 2012
    ..cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution...

Research Grants1

  1. Jennifer M Puck; Fiscal Year: 2014
    ..pathways, and we have discovered a new form of mouse SCID, deficiency of a predicted transcription factor Zbtb1. Mice lacking Zbtb1 have no T cells, but B lineage development is only mildly impaired...