ZAR1

Summary

Gene Symbol: ZAR1
Description: zygote arrest 1
Alias: Z3CXXC6, zygote arrest protein 1, oocyte-specific maternal effect factor, zinc finger, 3CxxC-type 6
Species: human

Top Publications

  1. ncbi Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 69:861-7. 2003
  2. ncbi Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:187-91. 2003
  3. pmc Maize ARGOS1 (ZAR1) transgenic alleles increase hybrid maize yield
    Mei Guo
    DuPont Pioneer, 7300 NW 62nd Ave, Johnston, Iowa 50131, USA
    J Exp Bot 65:249-60. 2014
  4. doi Insertion of inter-domain linkers improves expression and bioactivity of Zygote arrest (Zar) fusion proteins
    Jonathan M Cook
    Department of Integrative Biology, University of Colorado Denver, Denver, CO 80204, USA
    Protein Eng Des Sel . 2017
  5. pmc Differences in cytoplasmic maturation between the BCB+ and control porcine oocytes do not justify application of the BCB test for a standard IVM protocol
    Piotr Pawlak
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, 60 637 Poznan, Poland
    J Reprod Dev 60:28-36. 2014
  6. doi Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I
    Priscilla Brebi
    Molecular Pathology Laboratory, Department of Pathology
    Biomarkers 19:181-8. 2014
  7. doi Clinical (non-histological) diagnosis of advanced prostate cancer: Evaluation of treatment outcome after androgen deprivation therapy
    Chris F Heyns
    Department of Urology, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Tygerberg, Cape Town, South Africa
    S Afr J Surg 52:82-5. 2014
  8. doi Identification of frequent differentially methylated region in sporadic bladder cancers
    Ryo Hasegawa
    Division of Urology, Nihon University School of Medicine, Tokyo, Japan
    Urol Int 94:479-84. 2015
  9. pmc Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes
    Debora Dankert
    Institute of Anatomy, University Hospital Essen, University Duisburg Essen, Essen, Germany
    PLoS ONE 9:e108907. 2014
  10. doi Developmental competence and gene expression of immature oocytes following liquid helium vitrification in bovine
    Jun Yi Chen
    College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China Henan Provincial Key Laboratory for Grass Feeding Animal, Henan University of Science and Technology, Luoyang 471003, China
    Cryobiology 69:428-33. 2014

Research Grants

  1. POSTDOCTORAL MASTER IN CLINICAL RESEARCH
    ESTELA ESTAPE; Fiscal Year: 2001

Scientific Experts

  • Takao Watanabe
  • K Sugito
  • Tiziana A L Brevini
  • R Romar
  • Svetlana Uzbekova
  • Julien Bobe
  • Ping Zheng
  • Sebastien Elis
  • C F Heyns
  • Aurore Thelie
  • D Bebbere
  • G Michailidis
  • ESTELA ESTAPE
  • Jennifer D Lewis
  • Jonathan M Cook
  • N Saini
  • Heiner Niemann
  • Doris Herrmann
  • Yui Shinojima
  • Liyun Miao
  • Sandra Milena Bernal-Ulloa
  • Benjamin Geffroy
  • Tian Ying Yu
  • Xuemei Wu
  • Guoxun Wang
  • Min Jee Park
  • Ryo Hasegawa
  • Congjiao Sun
  • Daniel A Enquobahrie
  • Amanda Charlesworth
  • P Palta
  • Priscilla Brebi
  • Adam F Summers
  • Piotr Pawlak
  • S K Singla
  • M K Singh
  • Patrick Aldag
  • Mei Guo
  • Julia Heinzmann
  • R S Manik
  • M S Chauhan
  • Ulrich Baulain
  • K P Singh
  • Debora Dankert
  • Jun Yi Chen
  • Tomomi M Yamamoto
  • Cansu Agca
  • A Yadav
  • Amar Nath
  • Hiroyuki Kawashima
  • Hiroki Nagase
  • Srimoyee Ghosh
  • Xiaofei Wang
  • Kyoko Fujiwara
  • Jun Igarashi
  • Mike Diederich
  • P Pawlak
  • Jun Woo Jo
  • Andrea Lucas-Hahn
  • Darrell Desveaux
  • David S Guttman
  • M Hosoe
  • P R Adona
  • Smita Misra
  • Jianjun Hu
  • Gustavo Bruno Mota
  • S E Racedo
  • Anya Mendel
  • Lorenzo Sangiorgio
  • Monika Nowak-Imialek
  • Kazunobu Tsunemoto
  • Pu Zhang
  • V J Hall
  • Sophie Pennetier
  • Lingjuan Shan
  • Xiahe Huang
  • Dahua Chen
  • Yan Jiang
  • Jian Zhang
  • Yingchun Wang
  • Feng Cheng
  • Junshun Fang
  • Weirui Ma
  • Yue Yuan
  • Fang Zhou
  • Agnès Bardonnet
  • Sylke Winkler
  • Peng fei Jia
  • Matthias Vignon
  • Laurent Beaulaton

Detail Information

Publications57

  1. ncbi Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 69:861-7. 2003
    Zygote arrest 1 (ZAR1) is an ovary-specific maternal factor that plays essential roles during the oocyte-to-embryo transition. In mice, the Zar1 mRNA is detected as a 1...
  2. ncbi Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:187-91. 2003
    ..To understand these processes further, we identified genes called zygote arrest 1 (Zar1 and ZAR1 in mouse and human, respectively) as novel oocyte-specific genes...
  3. pmc Maize ARGOS1 (ZAR1) transgenic alleles increase hybrid maize yield
    Mei Guo
    DuPont Pioneer, 7300 NW 62nd Ave, Johnston, Iowa 50131, USA
    J Exp Bot 65:249-60. 2014
    ..This study reports that transgenic over-expression of Zea mays AR GOS1 (ZAR1) enhanced maize organ growth, grain yield, and drought-stress tolerance...
  4. doi Insertion of inter-domain linkers improves expression and bioactivity of Zygote arrest (Zar) fusion proteins
    Jonathan M Cook
    Department of Integrative Biology, University of Colorado Denver, Denver, CO 80204, USA
    Protein Eng Des Sel . 2017
    ..The Zygote arrest proteins, Zar1 and Zar2, are crucial for embryogenesis and have been implicated in binding mRNA and repressing mRNA translation...
  5. pmc Differences in cytoplasmic maturation between the BCB+ and control porcine oocytes do not justify application of the BCB test for a standard IVM protocol
    Piotr Pawlak
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, 60 637 Poznan, Poland
    J Reprod Dev 60:28-36. 2014
    ..transcript abundance of the BCB+ and the control oocytes in 5 out of 6 analyzed genes (BMP15, GDF9, ATP5A1, EEF1A, ZAR1) and in mtDNA content (pre-IVM 179609 vs. 176595 and post-IVM 187243 vs. 246984, respectively)...
  6. doi Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I
    Priscilla Brebi
    Molecular Pathology Laboratory, Department of Pathology
    Biomarkers 19:181-8. 2014
    ..Aberrant hypermethylation of promoter region of tumor suppressor genes could be used as cancer biomarkers...
  7. doi Clinical (non-histological) diagnosis of advanced prostate cancer: Evaluation of treatment outcome after androgen deprivation therapy
    Chris F Heyns
    Department of Urology, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Tygerberg, Cape Town, South Africa
    S Afr J Surg 52:82-5. 2014
    ..1 v. 26.8 months), documented PSA relapse (70% v. 67.7%), and patients alive at last follow-up (91.1% v. 95.8%). ZAR1 068 200 (US$1 = ZAR8) was saved by treating men with advanced ACP on the basis of a clinical (non-histological) ..
  8. doi Identification of frequent differentially methylated region in sporadic bladder cancers
    Ryo Hasegawa
    Division of Urology, Nihon University School of Medicine, Tokyo, Japan
    Urol Int 94:479-84. 2015
    ..levels in the cytosine-phosphate-guanine island (CpGi) region from exon 1 to intron 1 of the zygote arrest 1 (ZAR1) gene have been reported in several types of human cancers, including melanoma, brain tumor, and hepatocellular ..
  9. pmc Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes
    Debora Dankert
    Institute of Anatomy, University Hospital Essen, University Duisburg Essen, Essen, Germany
    PLoS ONE 9:e108907. 2014
    ..preovulatory-aged oocytes was also increased, along with transcript level declines of Trim28, Nlrp2, Nlrp14 and Zar1. In contrast to preovulatory aging, postovulatory aging of in vivo- and in vitro-grown oocytes led to a shortening ..
  10. doi Developmental competence and gene expression of immature oocytes following liquid helium vitrification in bovine
    Jun Yi Chen
    College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China Henan Provincial Key Laboratory for Grass Feeding Animal, Henan University of Science and Technology, Luoyang 471003, China
    Cryobiology 69:428-33. 2014
    ..Moreover, the expression of GDF9 (growth/differentiation factor-9), BAX (apoptosis factor) and ZAR1 (zygote arrest 1) was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) when the vitrified-..
  11. pmc Altered theca and cumulus oocyte complex gene expression, follicular arrest and reduced fertility in cows with dominant follicle follicular fluid androgen excess
    Adam F Summers
    Department of Animal Science, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 9:e110683. 2014
    ..Furthermore, abundance of ZAR1 was decreased 10-fold in cumulus oocyte complexes from High A4 cows, whereas NLRP5 abundance tended to be 19...
  12. pmc Early Pregnancy Maternal Blood DNA Methylation in Repeat Pregnancies and Change in Gestational Diabetes Mellitus Status—A Pilot Study
    Daniel A Enquobahrie
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA Department of Epidemiology, University of Washington, Seattle, WA, USA
    Reprod Sci 22:904-10. 2015
    ..to identified hypomethylated (such as NDUFC1, HAPLN3, HHLA3, and RHOG) or hypermethylated sites (such as SEP11, ZAR1, and DDR)...
  13. doi The handbook of play therapy and therapeutic play
    Anya Mendel
    a Clinical Psychologist Community Service, Division of Child and Adolescent Psychiatry, Red Cross War Memorial Children s Hospital, Cape Town
    J Child Adolesc Ment Health 21:181-2. 2009
    2009 (Second Edition), Routledge, London 281 pages, 2 tables, 6 figures Paperback, ISBN 978-0-415-43942-8, ZAR1 262.95.
  14. pmc Effective Oocyte Vitrification and Survival Techniques for Bovine Somatic Cell Nuclear Transfer
    Min Jee Park
    1 Mirae Cell Bio Inc, Seoul 143 854, Korea
    Cell Reprogram 17:199-210. 2015
    ..05). mRNA levels of maternal genes (ZAR1, BMP15, and NLRP5) and a stress gene (HSF1) were lower in the vitrification groups than in the non-V group (p<0...
  15. doi Developmental competence of different quality bovine oocytes retrieved through ovum pick-up following in vitro maturation and fertilization
    N Saini
    Animal Biotechnology Centre, National Dairy Research Institute, Karnal 132001, Haryana, India
    Animal 9:1979-85. 2015
    ..interaction (Cx43, Cx37, GDF9 and BMP15), (b) fertilization (ZP2 and ZP3), (c) embryonic development (HSF1, ZAR1 and bFGF) and (d) apoptosis and survival (BAX, BID and BCL-XL, MCL-1, respectively) was studied at two stages: ..
  16. pmc Promising Loci and Genes for Yolk and Ovary Weight in Chickens Revealed by a Genome-Wide Association Study
    Congjiao Sun
    National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China
    PLoS ONE 10:e0137145. 2015
    ..A list of candidate genes such as ZAR1, STARD13, ACER1b, ACSBG2, and DHRS12 were identified for having a plausible function in yolk and follicle ..
  17. doi The Decoy Substrate of a Pathogen Effector and a Pseudokinase Specify Pathogen-Induced Modified-Self Recognition and Immunity in Plants
    Guoxun Wang
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No 1 West Beichen Road, Beijing 100101, China
    Cell Host Microbe 18:285-95. 2015
    ..AvrAC recognition also requires the RKS1 pseudokinase of the ZRK family and the NOD-like receptor ZAR1, which is known to recognize the Pseudomonas syringae effector HopZ1a...
  18. pmc Cyclic AMP Affects Oocyte Maturation and Embryo Development in Prepubertal and Adult Cattle
    Sandra Milena Bernal-Ulloa
    Institute of Farm Animal Genetics, Biotechnology, Friedrich Loeffler Institut, Mariensee, Germany
    PLoS ONE 11:e0150264. 2016
    ..oocytes, mRNA abundance of PRKACA was higher for cAMP30 protocol and no differences were found for PDE3A, SMAD2, ZAR1, PRDX1 and SLC2A8...
  19. pmc The Arabidopsis Receptor Kinase ZAR1 Is Required for Zygote Asymmetric Division and Its Daughter Cell Fate
    Tian Ying Yu
    State Key Laboratory of Molecular Developmental Biology, National Center for Plant Gene Research Beijing, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 12:e1005933. 2016
    ..genetic screen for mutations affecting early embryogenesis, we identified an Arabidopsis mutant, zygotic arrest 1 (zar1), in which zygote asymmetric division and the cell fate of its daughter cells were impaired...
  20. pmc Sexually dimorphic gene expressions in eels: useful markers for early sex assessment in a conservation context
    Benjamin Geffroy
    INRA, UR1037 LPGP, Fish Physiology and Genomics, Campus de Beaulieu, 35000 Rennes, France
    Sci Rep 6:34041. 2016
    ..testis-specific expressions of dmrt1, amh, gsdf and pre-miR202 and ovary-specific expressions were obtained for zar1, zp3 and foxn5...
  21. doi Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish
    Liyun Miao
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Development 144:128-138. 2017
    ..In this study, we generated zebrafish zar1 mutants that result in early oocyte apoptosis and fully penetrant male development...
  22. pmc Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells
    Svetlana Uzbekova
    UMR 6175 Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique, Universite Francois Rabelais de Tours, Haras Nationaux, 37380 Nouzilly, France
    Reprod Biol Endocrinol 4:12. 2006
    Zygote arrest 1 (ZAR1) is one of the few known oocyte-specific maternal-effect genes essential for the beginning of embryo development discovered in mice...
  23. pmc The beneficial effects of antifreeze proteins in the vitrification of immature mouse oocytes
    Jun Woo Jo
    Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea
    PLoS ONE 7:e37043. 2012
    ..The AFP group showed increased Mad2, Hook-1, Zar1, Zp1, and Bcl2 expression and lower Eg5, Zp2, Caspase6, and Rbm3 expression compared with the untreated group...
  24. pmc The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a
    Jennifer D Lewis
    Department of Cell and Systems Biology and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON, Canada M5S 3B2
    Proc Natl Acad Sci U S A 110:18722-7. 2013
    ..ETI) when recognized in Arabidopsis thaliana by the nucleotide-binding leucine-rich repeat (NB-LRR) protein ZAR1. However, recognition of HopZ1a does not require any known ETI-related genes...
  25. pmc Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2
    Tomomi M Yamamoto
    Department of Integrative Biology, University of Colorado Denver, Denver, CO, USA Electronic address
    Biochim Biophys Acta 1829:1034-46. 2013
    Maternal mRNAs are translationally regulated during early development. Zar1 and its closely related homolog, Zar2, are both crucial in early development...
  26. doi Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas
    Kiminobu Sugito
    Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Pediatr Surg 48:782-8. 2013
    ..melanomas and brain tumors has led to the identification of non-promoter hypermethylation of zygote arrest 1 (ZAR1)...
  27. doi Effect of physiologically relevant heat shock on development, apoptosis and expression of some genes in buffalo (Bubalus bubalis) embryos produced in vitro
    A Yadav
    Embryo Biotechnology Lab, Animal Biotechnology Centre
    Reprod Domest Anim 48:858-65. 2013
    ..05) in Group III than that in controls, whereas that of GLUT1, ZAR1 and BMP15 was not significantly different among the three groups...
  28. doi Impact of gonadotropin supplementation on the expression of germ cell marker genes (MATER, ZAR1, GDF9, and BMP15) during in vitro maturation of buffalo (Bubalus bubalis) oocyte
    Amar Nath
    Division of Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar, 243122, India
    In Vitro Cell Dev Biol Anim 49:34-41. 2013
    ..the transcript abundance of germ cell marker genes [maternal antigen that embryos require (MATER), Zygote arrest 1 (ZAR1), growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15)] mRNA in buffalo (Bubalus ..
  29. doi 269 relative transcript abundance of eight marker genes in oocytes of prepubertal and cyclic gilts
    P Pawlak
    Poznan University of Life Sciences, Poznan, Poland
    Reprod Fertil Dev 25:282. 2012
    ..transcription and real-time PCR using fluorescence resonance energy transfer probes for 8 genes (BMP15, GDF9, ZAR1, ATP5A1, EEF1A1, GSTA2, TOP2B, SMARCA4)...
  30. doi Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes
    Cansu Agca
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Mol Reprod Dev 80:102-17. 2013
    ..Foxl2, Pde3a, Esr2, Fshr, Ybx2, Ccnd2, Ccnb1ip1, and Zp3); maternal effect genes required for embryo development (Zar1, Npm2, Nlrp5, Dnmt1, H1foo, and Zfp57); amino acid degradation; and ketogenesis (Hmgcs2, and Cpt1b)...
  31. doi DNA methylation and mRNA expression profiles in bovine oocytes derived from prepubertal and adult donors
    Mike Diederich
    Institute of Farm Animal Genetics, 31535 Mariensee, Neustadt, Germany
    Reproduction 144:319-30. 2012
    ..Here, we analyzed DNA methylation in three developmentally important, nonimprinted genes (SLC2A1, PRDX1, ZAR1) and two satellite sequences, i.e. 'bovine testis satellite I' (BTS) and 'Bos taurus alpha satellite I' (BTαS)...
  32. ncbi Expression pattern of zygote arrest 1 (ZAR1), maternal antigen that embryo requires (MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes in ovine oocytes and in vitro-produced preimplantation embryos
    Daniela Bebbere
    Department of Animal Biology, University of Sassari, Vienna, Sassari, Italy
    Reprod Fertil Dev 20:908-15. 2008
    The expression patterns of four maternal effect genes (MEG), namely zygote arrest 1 (ZAR1), maternal antigen that embryo requires (MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15), were determined ..
  33. ncbi Messenger RNA expression patterns of histone-associated genes in bovine preimplantation embryos derived from different origins
    Monika Nowak-Imialek
    Department of Biotechnology, Institute for Animal Breeding FAL, Mariensee, Neustadt, Germany
    Mol Reprod Dev 75:731-43. 2008
    ..formation [heterochromatin protein 1 (HP1)]; and chromatin-mediated transcription regulation [zygote arrest 1 (ZAR1)]. With the exception of ZAR1, these mRNAs were present throughout preimplantation development...
  34. pmc Search for the genes involved in oocyte maturation and early embryo development in the hen
    Sebastien Elis
    Physiologie de Reproduction et des Comportements, UMR 6175 INRA CNRS Université F, Rabelais de Tours, Haras Nationaux, 37380 Nouzilly, France
    BMC Genomics 9:110. 2008
    ....
  35. doi Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse
    Kazunobu Tsunemoto
    Department of Genetic Engineering, Kinki University, Kinokawa, Wakayama, Japan
    Mol Reprod Dev 75:1104-8. 2008
    We examined the promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters for cis-acting elements of 5'-flanking region to obtain the best promoter for ..
  36. doi A putative protein structurally related to zygote arrest 1 (Zar1), Zar1-like, is encoded by a novel gene conserved in the vertebrate lineage
    Lorenzo Sangiorgio
    Department of Animal Pathology, Hygiene and Public Veterinary Health, Section of Biochemistry and Physiology, Faculty of Veterinary Medicine, University of Milan, Via Celoria 10, 20133 Milan, Italy
    Comp Biochem Physiol B Biochem Mol Biol 150:233-9. 2008
    ..and characterization of a bovine cDNA and the corresponding gene coding for a novel protein structurally related to Zar1, therefore called Zar1-like, are here reported for the first time...
  37. pmc In silico identification and molecular characterization of genes predominantly expressed in the fish oocyte
    Julien Bobe
    INRA, UR1337, IFR140, Ouest genopole, Campus de Beaulieu, F 35000 Rennes, France
    BMC Genomics 9:499. 2008
    ..In teleost species, very little is known about "oocyte-specific" genes. The present study therefore aimed at identifying and characterizing oocyte-specific genes in fish...
  38. pmc Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells
    Smita Misra
    Division of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cancer 9:50. 2010
    ..cells, we discovered that this promoter has bi-directional activity and the product of the reverse activity (a ZAR1-like protein, we named ZAR2) silences the forward promoter at the G0/G1 phase of the cell...
  39. pmc Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo
    Aurore Thelie
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, F 37380 Nouzilly, France
    BMC Dev Biol 7:125. 2007
    ..We have investigated how post transcriptional control of maternal transcripts was affected during in vitro and in vivo maturation, as a model of differential developmental competence...
  40. ncbi Oocyte-specific genes affect folliculogenesis, fertilization, and early development
    Ping Zheng
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Reprod Med 25:243-51. 2007
    ..g., ZP1, ZP2, ZP3), and preimplantation embryonic development (e.g., NPM2, ZAR1, NALP5, DPPA3)...
  41. ncbi Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells
    Pu Zhang
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Huddinge, Sweden
    Fertil Steril 87:677-90. 2007
    ..To identify genes that are expressed differently during final oocyte maturation and early embryonic development in humans...
  42. ncbi Developmental competence of human in vitro aged oocytes as host cells for nuclear transfer
    V J Hall
    Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle upon Tyne, UK
    Hum Reprod 22:52-62. 2007
    ..Improving human nuclear transfer (NT) efficiencies is paramount for the development of patient-specific stem cell lines, although the opportunities remain limited owing to difficulties in obtaining fresh mature oocytes...
  43. ncbi Expression pattern of the maternal factor zygote arrest 1 (Zar1) in bovine tissues, oocytes, and embryos
    Tiziana A L Brevini
    Department of Anatomy of Domestic Animals, University of Milan, Milan, Italy
    Mol Reprod Dev 69:375-80. 2004
    Zygote arrest 1 (Zar1) is an ovary-specific maternal factor that plays an essential role during the oocyte-to-embryo transition in mouse...
  44. ncbi Spatio-temporal expression of the germ cell marker genes MATER, ZAR1, GDF9, BMP15,andVASA in adult bovine tissues, oocytes, and preimplantation embryos
    Sophie Pennetier
    Physiologie de la Reproduction et des Comportements, UMR 6175 Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université François Rabelais de Tours Haras Nationaux, F 37380 Nouzilly, France
    Biol Reprod 71:1359-66. 2004
    ..have analyzed the spatiotemporal expression of MATER, along with other potential markers of germ cells or oocytes: ZAR1 (zygotic arrest 1), GDF9 (growth and differentiation factor 9), BMP15 (bone morphogenetic protein 15), and VASA...
  45. doi Epigenetic modifications and related mRNA expression during bovine oocyte in vitro maturation
    S E Racedo
    Institute of Farm Animal Genetics FLI, Department of Biotechnology, Mariensee, 31535 Neustadt, Germany
    Reprod Fertil Dev 21:738-48. 2009
    ..the somatic isoform of DNA methyltransferase 1 (DNMT1), DNA methyltransferase 3b (DNMT3b) and zygote arrest 1 (ZAR1) was determined by RT-PCR...
  46. doi Developmental competence and expression of the MATER and ZAR1 genes in immature bovine oocytes selected by brilliant cresyl blue
    Gustavo Bruno Mota
    Departamento de Zootecnia, Universidade Federal de Vicosa, Vicosa, MG, 36571 000, Brazil
    Zygote 18:209-16. 2010
    ..the selection of immature bovine oocytes by brilliant cresyl blue dye (BCB) and expression of transcripts MATER and ZAR1. Cumulus-oocyte complexes (COCs) from slaughterhouse ovaries were exposed to BCB diluted in mDPBS and incubated for ..
  47. doi Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest
    Jianjun Hu
    The Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, People s Republic of China
    Dev Dyn 239:407-24. 2010
    ..However, the mechanisms that mediate these functions are largely unknown. Here we identified XM_359149, a Zar1-like gene that is predominantly expressed in oocytes and zygotes, which we designated Zar1-like (Zar1l)...
  48. doi Expression of chicken zygote arrest 1 (Zar1) and Zar1-like genes during sexual maturation and embryogenesis
    Georgios Michailidis
    Laboratory of Physiology of Reproduction of Farm Animals, Department of Animal Production, School of Agriculture, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece
    Vet Res Commun 34:173-84. 2010
    ..Zygote arrest 1 (Zar1) is an oocyte-specific maternal-effect gene that functions at the oocyte-to-embryo transition in many vertebrate ..
  49. doi Embryonic development and gene expression in oocytes cultured in vitro in supplemented pre-maturation and maturation media
    P R Adona
    Departamento de Ciencias Basicas, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de Sao Paulo, Pirassununga, SP, Brazil
    Reprod Domest Anim 46:e31-8. 2011
    ..05). Transcripts analysis showed that most genes (NLRP5, ZAR1, GPX1, KEAP1, SPHK2, HSP70 and PSMP1) were downregulated (p<0...
  50. pmc Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein
    Jennifer D Lewis
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 6:e1000894. 2010
    ..This reverse genetic screen revealed that the Arabidopsis R protein HOPZ-activated resistance 1 (ZAR1; At3g50950) is required for recognition of HopZ1a in Arabidopsis...
  51. ncbi 187 differential expressions of growth and differentiation factor 9 and bone morphogenetic protein 15 genes in ovaries of the calf and cow
    M Hosoe
    National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Reprod Fertil Dev 23:195. 2011
    ..in the collected cumulus and mural granulosa cells by determining the mRNA expression of germ cell-oocyte markers (ZAR1 and VASA)...
  52. doi Non-promoter hypermethylation of zygote arrest 1 (ZAR1) in human brain tumors
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Brain Tumor Pathol 28:199-202. 2011
    Zygote arrest 1 (ZAR1) is a novel maternal-effect gene of crucial importance during the oocyte-to-embryo transition...
  53. ncbi Aberrant hypermethylation of non-promoter zygote arrest 1 (ZAR1) in human brain tumors
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 50:1062-9. 2010
    Zygote arrest 1 (ZAR1) is a novel maternal-effect gene which is extremely important during the oocyte-to-embryo transition...
  54. pmc Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation
    Yui Shinojima
    Division of Cutaneous Science, Department of Dermatology, Nihon University Graduate School of Medicine, Tokyo 173 8610, Japan
    J Dermatol Sci 59:98-106. 2010
    ..Epigenetic changes such as aberrant DNA methylation and histone modification have been shown to play an important role in the tumorigenesis of malignant melanoma...
  55. doi Expression of maternal transcripts during bovine oocyte in vitro maturation is affected by donor age
    R Romar
    Faculty of Veterinary Science, Department of Physiology, University of Murcia, Murcia, Spain
    Reprod Domest Anim 46:e23-30. 2011
    ..Genes were selected based on their known maternal effect in mouse (ZAR1, STELLA, HSF1, MATER/NLRP5 and its paralogue NLRP9), or their identification as markers of oocyte maturation, ..

Research Grants1

  1. POSTDOCTORAL MASTER IN CLINICAL RESEARCH
    ESTELA ESTAPE; Fiscal Year: 2001
    ..4. Develop and prioritize goals and objectives for the curriculum, including 1 ZAR1-JRL-C(M2) 3 1R21 AR48043-01 April 25, 2001 Estape, Estella knowledge and skills objectives for trainees, and ..