XRCC3

Summary

Gene Symbol: XRCC3
Description: X-ray repair cross complementing 3
Alias: CMM6, DNA repair protein XRCC3, X-ray repair complementing defective repair in Chinese hamster cells 3, X-ray repair cross-complementing protein 3
Species: human

Top Publications

  1. ncbi Xrcc3 induces cisplatin resistance by stimulation of Rad51-related recombinational repair, S-phase checkpoint activation, and reduced apoptosis
    Zhi Yuan Xu
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, Canada H3T 1E2
    J Pharmacol Exp Ther 314:495-505. 2005
  2. ncbi Genetic polymorphisms in DNA repair genes and risk of lung cancer
    D Butkiewicz
    Department of Tumor Biology, Centre of Oncology, M Sklodowska Curie Memorial Institute, 44 101 Gliwice, Poland
    Carcinogenesis 22:593-7. 2001
  3. ncbi Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population
    Hongbing Shen
    Department of Epidemiology and Statistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China
    Cancer Lett 206:51-8. 2004
  4. doi A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility
    Paolo Vineis
    Department of Epidemiology and Public Health, Imperial College, London, UK
    J Natl Cancer Inst 101:24-36. 2009
  5. ncbi XRCC3 polymorphisms and risk of lung cancer
    Nicklas R Jacobsen
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Lett 213:67-72. 2004
  6. ncbi Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy
    A Ruzzo
    Institute of Biochemistry G Fornaini, University of Urbino, Urbino, Italy
    Pharmacogenomics J 8:278-88. 2008
  7. ncbi DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies
    Shizhong Han
    State Key Lab of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    Eur J Hum Genet 14:1136-44. 2006
  8. ncbi Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer
    Victor Moreno
    Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, Hospitalet, Barcelona, Spain
    Clin Cancer Res 12:2101-8. 2006
  9. ncbi Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2
    Shobbir Hussain
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s Hospital, London SE1 9RT, UK
    DNA Repair (Amst) 5:629-40. 2006
  10. ncbi Variants in DNA double-strand break repair genes and breast cancer susceptibility
    Bettina Kuschel
    Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
    Hum Mol Genet 11:1399-407. 2002

Detail Information

Publications193 found, 100 shown here

  1. ncbi Xrcc3 induces cisplatin resistance by stimulation of Rad51-related recombinational repair, S-phase checkpoint activation, and reduced apoptosis
    Zhi Yuan Xu
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, Canada H3T 1E2
    J Pharmacol Exp Ther 314:495-505. 2005
    ..We investigated the possible role of the Rad51-paralog protein Xrcc3 in drug resistance...
  2. ncbi Genetic polymorphisms in DNA repair genes and risk of lung cancer
    D Butkiewicz
    Department of Tumor Biology, Centre of Oncology, M Sklodowska Curie Memorial Institute, 44 101 Gliwice, Poland
    Carcinogenesis 22:593-7. 2001
    ..The frequencies of several amino acid substitutions in XRCC1 (Arg194Trp, Arg280His and Arg399Gln), XRCC3 (Thr241Met), XPD (Ile199Met, His201Tyr, Asp312Asn and Lys751Gln) and XPF (Pro379Ser) genes were studied in 96 non-..
  3. ncbi Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population
    Hongbing Shen
    Department of Epidemiology and Statistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China
    Cancer Lett 206:51-8. 2004
    ..case-control study in China, we tested the hypothesis that a C to T variant (Thr241Met) of DNA repair gene XRCC3 (X-ray repair cross-complementing group 3) is associated with risk of developing gastric cancer...
  4. doi A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility
    Paolo Vineis
    Department of Epidemiology and Public Health, Imperial College, London, UK
    J Natl Cancer Inst 101:24-36. 2009
    ..Although efforts have been made to create synopses for specific fields that summarize the data from genetic association studies, such an overview is not available for genes involved in DNA repair...
  5. ncbi XRCC3 polymorphisms and risk of lung cancer
    Nicklas R Jacobsen
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Lett 213:67-72. 2004
    ..have investigated the occurrence of lung cancer in relation to polymorphisms in the double strand DNA repair gene XRCC3. Among 54,220 members of a Danish prospective cohort study aged 50-65 at entry, 265 lung cancer cases were ..
  6. ncbi Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy
    A Ruzzo
    Institute of Biochemistry G Fornaini, University of Urbino, Urbino, Italy
    Pharmacogenomics J 8:278-88. 2008
    ..TS 3'-UTR 6+/6+ and XRCC3-241 C/C genotypes were associated with adverse PFS. Hazard ratio for PFS achieved 2.89 (95% confidence interval=1...
  7. ncbi DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies
    Shizhong Han
    State Key Lab of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    Eur J Hum Genet 14:1136-44. 2006
    The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility...
  8. ncbi Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer
    Victor Moreno
    Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, Hospitalet, Barcelona, Spain
    Clin Cancer Res 12:2101-8. 2006
    ..We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of developing colorectal cancer and the prognosis of patients...
  9. ncbi Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2
    Shobbir Hussain
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s Hospital, London SE1 9RT, UK
    DNA Repair (Amst) 5:629-40. 2006
    ..We therefore tested known FA proteins for direct interaction with RAD51 and its paralogs XRCC2 and XRCC3. FANCG was found to interact with XRCC3, and this interaction was disrupted by the FA-G patient derived mutation ..
  10. ncbi Variants in DNA double-strand break repair genes and breast cancer susceptibility
    Bettina Kuschel
    Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
    Hum Mol Genet 11:1399-407. 2002
    ..study analysing polymorphisms in genes involved in homologous recombination (NBS1, RAD52, RAD51, XRCC2 and XRCC3) and non-homologous end-joining (KU70/80 and LIG4)...
  11. ncbi Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Lett 190:183-90. 2003
    ..between three amino acid substitution variants of DNA repair genes (XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met) and breast cancer susceptibility...
  12. ncbi Polymorphisms in DNA repair and metabolic genes in bladder cancer
    Somali Sanyal
    Department of Biosciences at Novum, Karolinska Institute, S 14157 Huddinge, Sweden
    Carcinogenesis 25:729-34. 2004
    ..group C (XPC), group D (XPD) and group G (XPG), X-ray repair cross-complementing group 1 (XRCC1) and group 3 (XRCC3), Nijmegen breakage syndrome 1 (NBS1), cyclin D1, methylene-tetrahydrofolate reductase (MTHFR), NAD(P)H ..
  13. ncbi Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand
    Suparp Kietthubthew
    Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand
    Int J Hyg Environ Health 209:21-9. 2006
    ..polymorphisms (SNPs) in five common DNA repair genes were investigated: XRCC1 (Arg194Trp and Arg399Gln); XRCC3 (Thr241Met); XPC (PAT and Lys939Gln); XPD (exon 6, and Lys751Gln); and MGMT (Trp65Cys and Leu84Phe)...
  14. ncbi The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells
    X Cui
    Los Alamos National Laboratory, Life Sciences Division, NM 87545, USA
    Mutat Res 434:75-88. 1999
    The irs1 and irs1SF hamster cell lines are mutated for the XRCC2 and XRCC3 genes, respectively. Both show heightened sensitivity to ionizing radiation and particularly to the DNA cross-linking chemical mitomycin C (MMC)...
  15. ncbi A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer
    S L Winsey
    Department of Dermatology, University of Oxford, Churchill Hospital, United Kingdom
    Cancer Res 60:5612-6. 2000
    ..We found the presence of a T allele in exon 7 (position 18067) of the XRCC3 gene was significantly associated with melanoma development (P = 0.004; odds ratio, 2.36; relative risk, 1.74)...
  16. ncbi DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study
    G Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Turin, Italy
    Int J Cancer 92:562-7. 2001
    ..non-urological), 3 DNA polymorphisms localized in 3 genes of different repair pathways (XRCC1-Arg399Gln, exon 10; XRCC3-Thr241Met, exon 7; XPD-Lys751Gln, exon 23) have been analyzed...
  17. pmc Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C
    H Kurumizaka
    Genomic Sciences Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama shi, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 98:5538-43. 2001
    The human Xrcc3 protein is involved in the repair of damaged DNA through homologous recombination, in which homologous pairing is a key step...
  18. pmc Complex formation by the human RAD51C and XRCC3 recombination repair proteins
    J Y Masson
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Proc Natl Acad Sci U S A 98:8440-6. 2001
    ..Five paralogs of RAD51, known as RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3, have been identified and also shown to be required for recombination and genome stability...
  19. ncbi XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects
    G Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126, Torino, ISI Foundation, Institute for Scientific Interchange, Villa Gualino, 10133, Torino, Italy
    Carcinogenesis 22:1437-45. 2001
    ..by (32)P-DNA adduct levels, and three genetic polymorphisms in different repair genes: XRCC1-Arg399Gln (exon 10), XRCC3-Thr241Met (exon 7) and XPD-Lys751Gln (exon 23)...
  20. ncbi The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia
    Claire Seedhouse
    Division of Haematology, School of Clinical Laboratory Sciences, University of Nottingham, and Nottingham City Hospital, Nottingham, United Kingdom
    Blood 100:3761-6. 2002
    ..We studied polymorphisms in 3 DNA repair genes: XRCC1, XRCC3, and XPD...
  21. ncbi XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:1701-6. 2003
    The XRCC3 protein participates in DNA double-strand breaks and recombinational repair. A single C-to-T nucleotide change at codon 241 (Thr241Met) has been identified in the XRCC3 gene...
  22. pmc Domain mapping of the Rad51 paralog protein complexes
    Kristi A Miller
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
    Nucleic Acids Res 32:169-78. 2004
    ..proteins have been found to form two distinct complexes in vivo, Rad51B-Rad51C-Rad51D-Xrcc2 (BCDX2) and Rad51C-Xrcc3 (CX3)...
  23. ncbi Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Carcinogenesis 25:757-63. 2004
    ..K751Q), XPG (exon 15 G --> C, D1104H), XPC (exon 15 A --> C, K939Q), XRCC1 (exon 10 G --> A, R399Q) and XRCC3 (exon 7 C --> T, T241 M) and the levels of chromosomal aberrations (CAs) and single-strand breaks (SSBs) in ..
  24. ncbi Polymorphisms in DNA double-strand break repair genes and skin cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 64:3009-13. 2004
    ..We selected 11 haplotype-tagging single nucleotide polymorphisms in three DSB repair genes XRCC2, XRCC3, and LigaseIV and evaluated their associations with skin cancer risk in a nested case-control study within the ..
  25. ncbi XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  26. ncbi Human Rad51C deficiency destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells
    Yi Ching Lio
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 279:42313-20. 2004
    ..In vertebrates, five Rad51 paralogs (Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3) are expressed in mitotically growing cells and are thought to play mediating roles in homologous recombination, ..
  27. ncbi Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 25:2433-41. 2004
    ..lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met)...
  28. ncbi Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers
    Lode Godderis
    Katholieke Universiteit Leuven, Laboratorium Voor Arbeidshygiëne en Toxicologie, 3000 Leuven, Belgium
    Environ Mol Mutagen 44:293-303. 2004
    ..In the whole group of 88 individuals, higher frequencies of MNMC were found in individuals possessing the XRCC3 Met(241) allele and those individuals with the XRCC1 Gln( (399) ) allele showed higher frequencies of MNMC and ..
  29. ncbi Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer
    Penelope M Webb
    Population and Clinical Sciences Division, Queensland Institute of Medical Research and University of Queensland, Brisbane, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 14:319-23. 2005
    ..break repair gene polymorphisms RAD51 5' untranslated region -135 G > C, XRCC2 R188H G > A, and XRCC3 T241M C > T were associated with risk of breast or ovarian cancer in Australian women...
  30. ncbi Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism
    Fabiola Festa
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Mutat Res 574:105-11. 2005
    ..IL-1beta-511C/T; NBS1 exon 5 Glu185Gln; XPC exon 15 Lys939Gln; XPD exon 23 Lys751Gln; XRCC1 exon 10 Arg399Gln; XRCC3 exon 7 Thr241Met; cyclin D1 exon 4 G870A; MTHFR exon 4 Ala222Val and exon 7 Glu429Ala; HFE exon 4 C282Y were ..
  31. ncbi Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, Gent B 9000, Belgium
    Int J Radiat Oncol Biol Phys 62:1140-9. 2005
    To examine the association of polymorphisms in XRCC1 (194Arg/Trp, 280Arg/His, 399Arg/Gln, 632Gln/Gln), XRCC3 (5' UTR 4.541A>G, IVS5-14 17...
  32. ncbi Genetic polymorphisms and the effect of cigarette smoking in the comet assay
    Heike Hoffmann
    Universitatsklinikum Ulm, Abteilung Humangenetik, D 89070 Ulm, Germany
    Mutagenesis 20:359-64. 2005
    ..a subgroup of 32 nonsmokers and 31 smokers we also studied polymorphisms in XPD (Lys751Gln), XRCC1 (Arg399Gln) and XRCC3 (Thr241Val) because they are part of DNA repair pathways involved in the repair of tobacco-related DNA damage...
  33. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
    ..APE1/APEX, OGG1, MPG, XRCC1, PCNA, POLB, POLiota, LIG3 and EXO1; double-strand break repair (DSB-R) genes XRCC2, XRCC3, XRCC9, NBS1 and ATR; and direct damage reversal (DR) gene MGMT/AGT...
  34. ncbi DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    G Matullo
    ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Carcinogenesis 27:997-1007. 2006
    ..20, 95% confidence intervals (CI) = 1.16-4.17] and XRCC3-241 Met/Met homozygotes (OR = 0.51, 95% CI = 0.27-0.96) and leukaemia...
  35. ncbi Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients
    R de Las Peñas
    Hospital Provincial de Castellón, Castellon, Spain
    Ann Oncol 17:668-75. 2006
    ..the association of survival with genetic polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide ..
  36. pmc Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer
    Márcia Cristina Duarte
    Departamento de Biologia, UNESP, Sao Paulo State University, Sãao Jose do Rio Preto, SP, Brazil
    World J Gastroenterol 11:6593-600. 2005
    To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.
  37. ncbi DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil
    Rozany Mucha Dufloth
    Centro de Atenção Integral à Saúde da Mulher CAISM, Universidade Estadual de Campinas, Campinas, SP, Brasil
    Genet Mol Res 4:771-82. 2005
    ..Polymorphisms have been identified in several DNA repair genes, such as XRCC1, XPD, XRCC3, and RAD51, but the influence of specific genetic variants on repair phenotype and cancer risk has not yet been ..
  38. ncbi Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin
    Ranjit Kumar Thirumaran
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 27:1676-81. 2006
    ..The variant allele for T241M (C>T) polymorphism in the XRCC3 gene was associated with a decreased cancer risk [odds ratio (OR), 0.73; 95% confidence interval (CI), 0.61-0...
  39. ncbi Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers
    Charlotta Ryk
    Department of Biosciences and Nutrition, Karolinska Institute, S 141 57 Huddinge, Sweden
    Lung Cancer 54:285-92. 2006
    ..base excision repair (BER) genes, XRCC1 and APEX1 and two genes involved in homologous recombination repair (HR), XRCC3 and NBS1...
  40. ncbi Role of RAD51C and XRCC3 in genetic recombination and DNA repair
    Yilun Liu
    Clare Hall Laboratories, London Research Institute, Cancer Research UK, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    J Biol Chem 282:1973-9. 2007
    ..Five proteins (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) that share homology with RAD51 recombinase and are known as the RAD51 paralogs are important for recombinational ..
  41. ncbi Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials
    Nataliya Kuptsova
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Blood 109:3936-44. 2007
    ..We evaluated the role of polymorphisms in DNA repair genes APE1, XRCC1, ERCC1, XPD, and XRCC3 in predicting therapeutic outcomes of older adults with acute myeloid leukemia (AML) from 2 Southwest Oncology ..
  42. ncbi XRCC3 depletion induces spontaneous DNA breaks and p53-dependent cell death
    Martin Loignon
    Oncology Department, MCETC, and Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Cell Cycle 6:606-11. 2007
    In vertebrate cells, Xrcc3 initiates the repair of exogenous induced-DNA breaks during S and G(2)/M phases of the cell cycle by homologous recombination...
  43. pmc Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain
    M Felicitas López-Cima
    Departamento de Medicina, Facultad de Medicina, Unidad de Epidemiología Molecular del Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain
    BMC Cancer 7:162. 2007
    ..between polymorphisms in two NER genes, XPC (poly (AT) insertion/deletion: PAT-/+) and XPD (Asp312Asn and Lys751Gln), the BER gene XRCC1 (Arg399Gln), and the DSBR gene XRCC3 (Thr241Met) and the risk of developing lung cancer.
  44. ncbi MC1R variants associated susceptibility to basal cell carcinoma of skin: interaction with host factors and XRCC3 polymorphism
    Dominique Scherer
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:1787-93. 2008
    ..interaction of risk due to the MC1R variants and the common allele (high risk) of the T241M polymorphism in the XRCC3 gene. Our data confirmed the status of the nonsynonymous MC1R variants as independent genetic risk factors for BCC...
  45. pmc Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set
    Jonathan Beesley
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007
    ..in genes involved in steroid hormone synthesis (SRD5A2, CYP19A1, HSB17B1, and HSD17B4) and DNA repair (XRCC2, XRCC3, BRCA2, and RAD52) using two Australian ovarian cancer case-control studies, comprising a total of 1,466 cases and ..
  46. doi Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan
    Ching Yu Yen
    Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, and School of Dentistry, Taipei Medical University, Taipei, Taiwan
    J Oral Pathol Med 37:271-7. 2008
    ..In this study, we focused on the joint effect for SNP combinations of four DNA repair genes, X-ray repair cross-complementing groups (XRCCs) 1-4, involved in major cancer-related pathways...
  47. doi Efficiency of the DNA repair and polymorphisms of the XRCC1, XRCC3 and XRCC4 DNA repair genes in systemic lupus erythematosus
    Cl Bassi
    Department of Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo FMRP USP, Ribeirao Preto, Brazil
    Lupus 17:988-95. 2008
    ..in repairing DNA damage induced by ionizing radiation and (b) the association of DNA repair gene (XRCC1 Arg399Gln, XRCC3 Thr241Met and XRCC4 Ile401Thr) polymorphisms in SLE patients, considering the whole group, or stratified sub-..
  48. ncbi Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population
    Giuseppina Improta
    Laboratory of Molecular Oncology, Centro di Riferimento Oncologico Regionale della Basilicata, Istituto di Ricovero e Cura a Carattere Scientifico, Rionero in Vulture, Potenza, Italy
    Anticancer Res 28:2941-6. 2008
    ..study was designed to examine the polymorphisms associated with two DNA repair genes, namely XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met, and to investigate their role as susceptibility markers for lung and colorectal cancer.
  49. pmc Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium
    C L Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Br J Cancer 100:412-20. 2009
    ..CYP3A4 encodes a key enzyme in oestrogen metabolism and our finding between rs2740574 and risk of ovarian cancer suggests that this pathway may be involved in ovarian carcinogenesis. Additional follow-up is warranted...
  50. pmc Genetic polymorphisms in DNA repair genes as modulators of Hodgkin disease risk
    Randa El-Zein
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 1439, USA
    Cancer 115:1651-9. 2009
    ..However, to the authors' knowledge, few studies to date have investigated the role of such polymorphisms as risk factors for development of HD...
  51. pmc Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer
    J Chang-Claude
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 100:1680-6. 2009
    ..Polymorphisms in genes involved in DNA repair (APEX1, XRCC1, XRCC2, XRCC3, XPD) and damage response (TP53, P21) were determined...
  52. doi Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer
    Renata Krupa
    Laboratory of DNA Repair, Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Exp Mol Pathol 87:32-5. 2009
    The RAD51 protein and its paralog, XRCC3, play an important role in the repair of DNA double-strand breaks (DSBs) by homologous recombination...
  53. doi A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk
    Zheng Jiang
    Department of Colorectal Surgery, Cancer Hospital, Fudan University, 270 Dong An Road, Shanghai 200032, China
    Int J Colorectal Dis 25:169-80. 2010
    Studies on polymorphism of X-ray repair cross-complementing group 1 (XRCC1), group 3 (XRCC3), and colorectal cancer risk are inconclusive...
  54. doi XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 122:489-93. 2010
    Published data on the association between XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed...
  55. doi Predictive effects of ERCC1 and XRCC3 SNP on efficacy of platinum-based chemotherapy in advanced NSCLC patients
    Caicun Zhou
    Medical Oncology Department, Tongji University Affiliated Shanghai Pulmonary Hospital and Tongji University Medical School Cancer Institute, No 507, Zhengmin Road, Shanghai 200433, People s Republic of China
    Jpn J Clin Oncol 40:954-60. 2010
    ....
  56. doi XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: a meta-analysis
    Haiming Sun
    Harbin Medical University, China
    Cancer Sci 101:1777-82. 2010
    Several studies have investigated the associations between X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and the susceptibility to lung cancer and bladder cancer, but results have been inconclusive...
  57. doi Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma
    Adina Figl
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
    Mutat Res 702:8-16. 2010
    ..Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma...
  58. pmc The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells
    Veronica L Martinez-Marignac
    McGill University, Lady Davis Institute and Segal Cancer Center, Jewish General Hospital, Montreal, Canada
    PLoS ONE 6:e16394. 2011
    ..We assessed the effect of the DNA repair proteins known as X-ray complementing protein 3 (XRCC3) and RAD51, to the invasive behavior of the MCF-7 luminal epithelial-like and BT20 basal-like triple negative ..
  59. doi RAD51 and XRCC3 gene polymorphisms and the risk of developing acute myeloid leukemia
    Mona S Hamdy
    Department of Clinical and Chemical Pathology, Faculty of Medicine, El Kasr El Aini Hospital, Cairo, Egypt
    J Investig Med 59:1124-30. 2011
    ..The x-ray repair cross complementing (XRCC3) protein also functions in HR-DNA-DSB repair pathway and directly interacts with and stabilizes RAD51 and the ..
  60. doi Association between the XRCC3 polymorphisms and breast cancer risk: meta-analysis based on case-control studies
    Xiao Feng He
    Central Laboratory, Peace Hospital of Changzhi Medical College, Changzhi, 046000, China
    Mol Biol Rep 39:5125-34. 2012
    The previous published data on the association between X-ray repair cross-complementing group 3 (XRCC3) T241M, A4541G, and A17893G polymorphisms and breast cancer risk remained controversial...
  61. ncbi Prognostic significance of GSTP1, XRCC1 and XRCC3 polymorphisms in non-small cell lung cancer patients
    Hong Gang Ke
    Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
    Asian Pac J Cancer Prev 13:4413-6. 2012
    ..Our study aimed to investigate the prognostic role of GSTP1, XRCC1 and XRCC3 in NSCLC patients treated with chemotherapy.
  62. ncbi Association between the XRCC3 T241M polymorphism and head and neck cancer susceptibility: a meta-analysis of case-control studies
    Qing Hua Yin
    Yueyang Second People s Hospital, Yueyang, China
    Asian Pac J Cancer Prev 13:5201-5. 2012
    To evaluate the role of the X-ray repair cross complementing group 3 (XRCC3) T241M polymorphism in head and neck cancer susceptibility.
  63. pmc XRCC3 Thr241Met gene polymorphisms and lung cancer risk: a meta-analysis
    Ping Zhan
    First Department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing, 210029, China
    J Exp Clin Cancer Res 32:1. 2013
    Many studies have examined the association between the XRCC3 Thr241Met gene polymorphism and lung cancer risk in various populations, but their results have been inconsistent...
  64. pmc ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair
    Kumar Somyajit
    Department of Biochemistry, Indian Institute of Science, Bangalore, India
    Mol Cell Biol 33:1830-44. 2013
    The RAD51 paralogs XRCC3 and RAD51C have been implicated in homologous recombination (HR) and DNA damage responses. However, the molecular mechanism(s) by which these paralogs regulate HR and DNA damage signaling remains obscure...
  65. pmc XRCC3 gene polymorphism is associated with survival in Japanese lung cancer patients
    Kayo Osawa
    Faculty of Health Sciences, Kobe University Graduate School of Health Sciences, Kobe 654 0142, Japan
    Int J Mol Sci 13:16658-67. 2012
    We focused on OGG1 Ser326Cys, MUTYH Gln324His, APEX1 Asp148Glu, XRCC1 Arg399Gln, and XRCC3 Thr241Met and examined the relationship between the different genotypes and survival of Japanese lung cancer patients...
  66. doi Association between the XRCC3 T241M polymorphism and risk of cancer: evidence from 157 case-control studies
    Xiao Feng He
    Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, 046000, PR China
    Gene 523:10-9. 2013
    The T241M polymorphism in the X-ray cross-complementing group 3 (XRCC3) had been implicated in cancer susceptibility. The previous published data on the association between XRCC3 T241M polymorphism and cancer risk remained controversial...
  67. doi Association between the XRCC3 C241T polymorphism and lung cancer risk in the Asian population
    Xin Tian
    Molecular Oncology Department of Cancer Research Institution, The First Hospital of China Medical University, Shenyang, 110001, China
    Tumour Biol 34:2589-97. 2013
    X-ray repair cross-complementing group 3 (XRCC3) plays a vital role in maintaining the stability of genome by homologous recombination repair for DNA double-strand breaks...
  68. doi Comprehensive assessment of the association between DNA repair gene XRCC3 Thr241Met polymorphism and leukemia risk
    Lingyan Qin
    Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, Guangxi, People s Republic of China
    Tumour Biol 35:2521-8. 2014
    The XRCC3 gene has been suggested to play an important role in the pathogenesis of leukemia risk. But the findings of publications are contradictory. To derive a more precise estimation of the association, we performed a meta-analysis...
  69. pmc XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 13:2633-8. 1999
    ..The highly conserved strand transferase, Rad51, is expected to be critical for this process. XRCC3 possesses a limited sequence similarity to Rad51 and interacts with it...
  70. ncbi Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia
    Claire Seedhouse
    Division of Haematology, School of Clinical Laboratory Sciences, University of Nottingham, and Nottingham City Hospital, Nottingham, United Kingdom
    Clin Cancer Res 10:2675-80. 2004
    Double-strand break repair via homologous recombination is essential in maintaining genetic integrity. RAD51 and XRCC3 are involved in the repair of DNA by this pathway, and polymorphisms have been identified in both the RAD51 (RAD51-..
  71. pmc Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene
    R S Tebbs
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, CA 94551 0808, USA
    Proc Natl Acad Sci U S A 92:6354-8. 1995
    ..analysis of somatic cell hybrids formed between irs1SF and human lymphocytes implicated a human gene (defined as XRCC3; x-ray repair cross-complementing), which partially restored mitomycin C resistance to the mutant...
  72. pmc Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan
    Chih Ching Yeh
    Institute of Environmental Health, National Taiwan University College of Public Health, Taipei 100, Taiwan
    BMC Cancer 5:12. 2005
    ..This study was designed to examine the polymorphisms associated with three DNA repair genes, namely: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, and investigate their role as susceptibility markers for colorectal cancer.
  73. ncbi Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma
    Alan G Casson
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Carcinogenesis 26:1536-41. 2005
    ..wild-type and polymorphic variants of XPD (Arg156Arg and Lys751Gln), XRCC1 (Arg194Trp and Arg399Gln) and XRCC3 (Thr241Met), and the poly (AT) insertion/deletion of XPC (PAT)...
  74. ncbi Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005
    ..polymorphisms in four DNA repair genes: MGMT (Leu84Phe and Ile143Val), XRCC1 (Arg399Gln), XPD (Lys751Gln), and XRCC3 (Thr241Met). All single-nucleotide polymorphisms were assayed in a single laboratory...
  75. ncbi Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility
    Anna Renglin Lindh
    Departmen tof Genetics, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden
    Hum Mol Genet 15:1217-24. 2006
    The XRCC3 variant T241M, but not D213N, has been reported to be associated with an increased risk of some cancers. XRCC3 is one out of five RAD51 paralogues and is involved in homologous recombination, as are the BRCA1 and BRCA2 proteins...
  76. doi FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3
    J B Wilson
    Molecular Oncology and Stem Cell Research Group, School of Biological Sciences, University of Liverpool, Liverpool, UK
    Oncogene 27:3641-52. 2008
    ..We also show that phosphorylation of FANCG serine 7 is required for its co-precipitation with BRCA2, XRCC3 and FANCD2, as well as the direct interaction of BRCA2-FANCD2...
  77. ncbi A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 99:869-72. 2002
    ..the hypothesis that a C to T variant (Thr241Met) of DNA repair gene X-ray repair cross-complementing group 3 (XRCC3) is associated with risk of developing squamous cell carcinoma of the head and neck (SCCHN)...
  78. ncbi DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:939-43. 2002
    ..We examined the role of a common polymorphism in the XRCC3 gene (codon 241: threonine to methionine change) and bladder cancer risk...
  79. ncbi No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer
    Nicklas Raun Jacobsen
    National Institute of Occupational Health, DK 2100 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 12:584-5. 2003
  80. ncbi The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population
    Ming juan Jin
    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310031, China
    Cancer Genet Cytogenet 163:38-43. 2005
    Growing evidence suggests that the Thr241Met (T241M) polymorphism in the homologous recombination repair gene XRCC3 may alter DNA repair capacity and subsequent susceptibility to carcinogens...
  81. ncbi Genetic variants of DNA repair genes and prostate cancer: a population-based study
    Jamie D Ritchey
    George Washington University School of Public Health and Health Services, Washington, District of Columbia, USA
    Cancer Epidemiol Biomarkers Prev 14:1703-9. 2005
    ..18; 95% confidence interval (CI), 0.99-4.81 and OR, 1.99; 95% CI, 1.19-3.34, respectively]. In contrast, XRCC3-Thr241Met, XPD-Lys751Gln, and MGMT-Ile143Val markers showed no significant associations with risk, although due to ..
  82. pmc Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer
    R Mort
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Br J Cancer 89:333-7. 2003
    ..the frequency of polymorphisms in the NER genes, XPD, XPF, XPG, ERCC1; in the BER gene, XRCC1; and in the RR gene, XRCC3; in colorectal cancer patients and in a control group...
  83. pmc Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
    Environ Health Perspect 111:1843-50. 2003
    ..preferentially involved with base excision repair (BER) and nucleotide excision repair (NER) activities (XRCC1, XRCC3, APE1, XPD) corresponding to the repair of X-ray- and UV light-induced DNA damage, respectively...
  84. doi Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer
    Domenico Palli
    Molecular and Nutritional Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Via Cosimo il Vecchio 2, 50139 Florence, Italy
    Mutagenesis 25:569-75. 2010
    ..OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by ..
  85. ncbi Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280)
    Mousumi Majumder
    Human Genetics Unit, Indian Statistical Institute, Kolkata
    Cancer Epidemiol Biomarkers Prev 14:2106-12. 2005
    ..were studied to determine risk of the disease due to polymorphisms at three sites on XRCC1 and one site on XRCC3. Independently, variant genotypes on these loci did not modulate risk of leukoplakia and cancer except for the ..
  86. ncbi Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation
    Lode Godderis
    Katholieke Universiteit Leuven K U L, Laboratorium Voor Arbeidshygiëne en Toxicologie, Kapucijnenvoer 35 6, 3000 Leuven, Belgium
    Toxicology 219:220-9. 2006
    ..in rejoining single strand breaks (XRCC1) and in repair of cross-links and chromosomal double strand breaks (XRCC3) might have an impact on genotoxicity as well...
  87. doi Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination
    Hatsumi Nagasawa
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 7:515-22. 2008
    ..we examined additional Chinese hamster cell lines deficient in the Rad51 paralogs Rad51C, Rad51D, Xrcc2, and Xrcc3 as well as another essential HRR protein, Brca2...
  88. doi Cyclobutane pyrimidine dimers do not fully explain the mutagenicity induced by UVA in Chinese hamster cells
    Anna Biverstål
    Stockholm University, Department of Genetics, Microbiology and Toxicology, Stockholm, Sweden
    Mutat Res 648:32-9. 2008
    ..e., wild-type, Cockayne syndrome B protein-deficient (CSB), XRCC3-deficient and XRCC1-deficient adjusted to the same level of CPDs which was analyzed as strand breaks as a result ..
  89. doi Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation
    Masamichi Kajita
    Department of Bioscience and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Biosci Bioeng 110:351-8. 2010
    ..To this end, we disrupted the XRCC3 gene that is essential for gene conversion...
  90. ncbi Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Science of Czech Republic, 14200 Prague, Czech Republic
    Environ Mol Mutagen 44:283-92. 2004
    ..GSTP1, and GSTT1) and in genes involved in DNA repair (XPD exon 23, XPG exon 15, XPC exon 15, XRCC1 exon 10, and XRCC3 exon 7)...
  91. ncbi The genetics of susceptibility to cutaneous melanoma
    Julia A Newton Bishop
    Division of Genetic Epidemiology, Cancer Research UK, St James s Hospital, Leeds, UK
    Drugs Today (Barc) 41:193-203. 2005
    ..Good candidates such as the DNA repair gene XRCC3 and polymorphisms of EGF have been studied but excluded...
  92. ncbi DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns
    Caroline L Relton
    Genetics Unit, Westlakes Research Institute, Moor Row, Cumbria CA24 3JY, UK
    Mutat Res 545:49-57. 2004
    ..somatic mutation assay, in relation to polymorphic variation among 435 newborn babies in DNA repair genes XRCC1, XRCC3 and XRCC4 and gender, parental age, social class and smoking habits...
  93. ncbi Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity
    J J Hu
    Department of Cancer Biology and Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 22:917-22. 2001
    ..repair cross complementing group 1 (XRCC1, exon 6, C/T, 194 Arg/Trp and exon 10, G/A, 399 Arg/Gln), XRCC group 3 (XRCC3, exon 7, C/T, 241 Thr/Met) and apurinic/apyrimidinic endonuclease 1 (APE1, exon 5, T/G, 148 Asp/Glu)...
  94. ncbi Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation
    J E Sale
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 412:921-6. 2001
    ..Here we show that if the RAD51 paralogues XRCC2, XRCC3 or RAD51B are ablated the pattern of diversification of the immunoglobulin V gene in the chicken DT40 B-cell ..
  95. pmc Unventilated indoor coal-fired stoves in Guizhou province, China: cellular and genetic damage in villagers exposed to arsenic in food and air
    Aihua Zhang
    Department of Toxicology, School of Public Health, Guiyang Medical University, 9 Beijing Road, Guiyang City, 550004 Guizhou Province, People s Republic of China
    Environ Health Perspect 115:653-8. 2007
    ..Because the poisoning mechanism involved in arsenicosis is as yet unknown and no effective therapy exists, progress has been slow on the prevention and therapy of arsenicosis...
  96. doi Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate
    Teodora Nikolova
    Institute of Toxicology, Medical Center of the University Mainz, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    DNA Repair (Amst) 9:1050-63. 2010
    ..We show that HR defective cells (BRCA2, Rad51D and XRCC3 mutants) are dramatically more sensitive to MMS-induced DNA damage as measured by colony formation, apoptosis and ..
  97. pmc Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM
    Seiki Hirano
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan
    EMBO J 24:418-27. 2005
    ..To investigate the mechanism of the elevated SCE, we deleted FANCC in cells lacking Rad51 paralog XRCC3, TLS factor RAD18, or BLM...
  98. ncbi Molecular biomonitoring of a population of nurses handling antineoplastic drugs
    Tommaso Cornetta
    Department of Biology, Roma Tre University, Viale Guglielmo Marconi, 446 00146 Rome, Italy
    Mutat Res 638:75-82. 2008
    ..may be genetically determined, we studied the possible influence of single nucleotide polymorphism in XRCC1 and XRCC3 DNA repair genes on induced genetic damage...
  99. pmc Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C
    Otto S Gildemeister
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 284:31945-52. 2009
    ..Rad51 nuclear transport, we analyzed subcellular fractions for two other Rad51-interacting proteins, Rad51C and Xrcc3. Rad51C has a functional nuclear localization signal, and although we found that the subcellular distribution of ..
  100. doi Omental lipoblastoma
    Stephanie A Koplin
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, CSC 3224, 600 Highland Avenue, Madison, WI 53792, USA
    Pathol Res Pract 204:277-81. 2008
    ..Cancer Genet. Cytogenet. 168 (2006) 150-154]. We report this unique case of an omental lipoblastoma with a focus on its unusual karyotype, as well as its differentiation from myxoid liposarcoma...
  101. pmc The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51
    J Y Masson
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    EMBO J 18:6552-60. 1999
    ..Consistent with the requirement for two recombinases in meiotic recombination, hDmc1 interacts directly with hRad51...

Research Grants32

  1. Understanding the role of RAD51C complexes in recombination and repair
    Yilun Liu; Fiscal Year: 2012
    ..Previously, We identified two of the RAD51 paralogs, RAD51C and XRCC3, as the essential components of Holliday junction resolvasome, a complex required for separate linked chromosomes ..
  2. Cellular and Biochemical Regulation of Human Rad51 Function
    Kendall L Knight; Fiscal Year: 2010
    ..advantage of our recently published methodology using RNAi to analyze the function of mutant Rad51, Rad51C and Xrcc3 proteins in human cells...
  3. REPAIR AND RECOMBINATION IN RADIATION SENSITIVE CELLS
    Rodney Nairn; Fiscal Year: 2003
    ..The role of the XRCC3 gene, which may be also involved in crosslink repair through homologous recombination mechanisms, will be studied ..
  4. Molecular Genetics of Colon Cancer in Blacks and Whites
    Jennifer Hu; Fiscal Year: 2005
    ..GSTM]/T1), two base excision repair genes (XRCC1 and APE), a gene in double-strand break/recombination repair (XRCC3), and a nucleotide excision repair gene (XPD)...
  5. Gamma-ray-induced mutagen sensitivity in breast cancer
    Li E Wang; Fiscal Year: 2005
    ..2): To determine the correlation between polymorphisms of three select DNA repair genes (XRCC3, XRCC7 and RAD51) involved in DSBR and the G2 chromosomal radiosensitivity (phenotype) and their modulation of ..
  6. Molecular Epidemiology of t-MDS/AML
    Sara Strom; Fiscal Year: 2007
    ..GSTs, MPO, NQO1, CYPP2E1) or in DMA repair (eg. XRCC1, XRCC3, XPD), as well as epidemiological risk factors( e.g...
  7. Homologous Recombination & Human Cell Radiosensitivity
    LAWRENCE THOMPSON; Fiscal Year: 2009
    ..AIM 2 will construct null mutant lines of XRCC3 in Tp53-normal immortalized diploid human fibroblasts and assess their genomic instability with respect to ..
  8. Role of Rad51 Paralogs in Mammalian DNA Repair
    Patrick Sung; Fiscal Year: 2006
    ..Interestingly, in vertebrate cells, five Rad51-like proteins -XRCC2, XRCC3, Rad51B, Rad51C, and Rad51C- commonly called Rad51 paralogs, have been identified...
  9. DNA repair, genetic variation and skin cancer
    David Hunter; Fiscal Year: 2003
    ..haplotypes in three important DNA repair genes (XPD in nucleotide excision repair; XRCC1 in base excision repair; XRCC3 in homologous recombination repair) are associated with higher risk of skin cancer...
  10. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003
    ..CYP2C19, CYP3A4, thiopurine methyltransferase, methylguanine DNA methyltransferase, ERCC1, XPD, XRCC1, XRCC2, XRCC3, XRCC4 and XRCC5...
  11. Molecular Epidemiology of Colorectal Adenomas
    Robert Haile; Fiscal Year: 2005
    ..Specifically, we propose to study MTHFR, MTRR, ADH3, which may affect folate metabolism, and XRCC1, XRCC3, OGG1, and MGMT, which may be involved in DNA repair of damage associated with folate metabolism...
  12. The roles of XPF/ERCC1 complex in DNA repair
    Tadayoshi Bessho; Fiscal Year: 2007
    ..The genetic data also indicate the involvement of XRCC2 and XRCC3 in XL repair...
  13. GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT
    Sandra Hoffman; Fiscal Year: 2003
    ..ADH, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, EH); and 3) control DNA repair processes (XRCC1, XRCC3, XPD)...
  14. Genetic Dissection of BRCA1's Recombination Function
    DOUGLAS BISHOP; Fiscal Year: 2007
    ..These phenotypes will be compared to those conferred by mutation of the XRCC3 gene, which is also required for assembly of recombination complexes 2...
  15. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2010
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  16. Nucleotide Excision Repair Gene Variants and Skin Cancer
    Jiali Han; Fiscal Year: 2005
    ..abstract_text> ..
  17. Prospective Study of DNA Repair Gene Variants in Breast Cancer
    Jiali Han; Fiscal Year: 2009
    ..This innovative work is essential to advance this field, and it has substantial potential for application to other areas of cancer susceptibility. ..
  18. Genetic Variants in Pigmentation Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying high-risk individuals for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  19. Genetic Variants in Immunological Mediator Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying individuals at high-risk for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  20. CASE CONTROL STUDY OF RISK FACTORS FOR WILMS TUMOR
    Andrew Olshan; Fiscal Year: 2002
    ..This study will provide important new advances in our understanding of Wilms tumor given the study size, quality of exposure assessment, and incorporation of clinical and biological markers of etiologic heterogeneity. ..
  21. Solar Exposure and Melanoma Survival
    Marianne Berwick; Fiscal Year: 2009
    ..2. Determine whether functional polymorphic variants in the vitamin D receptor affect survival from melanoma. 3. Investigate the interaction of lifetime solar exposure and polymorphisms in VDR and its effect on survival. ..
  22. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  23. Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer Recurrence
    Erich Sturgis; Fiscal Year: 2008
    ..abstract_text> ..
  24. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  25. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2007
    ..3) To elucidate the role that specific polymorphisms in DNA repair capacity genes (XRCC1, XPD and XRCC3) and cell cycle control (p53 gene) play in the modulation of HD outcome...
  26. Remodeling of Telomeres by Telomere Associated Proteins
    SARAH COMPTON; Fiscal Year: 2007
    ..In addition, we will study the role of NBS1 and XRCC3, two proteins involved in homologous recombination and telomere maintenance, for their ability to recognize and ..
  27. ANALYSIS OF HUMAN RAD51 RELATED PROTEINS
    David Schild; Fiscal Year: 2001
    ..In human cells, six proteins in this family (HsRad51, XRCC2, XRCC3, Rad51B/hRec2, Rad51C and Rad51D) likely participate in recombinatorial repair and in maintaining genomic ..
  28. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. BIOLOGICAL FUNCTION OF XRCC2 IN RECOMBINATIONAL REPAIR
    Nan Liu; Fiscal Year: 2003
    ..This study will lead to a better understanding of the role of XRCC2 in mammalian HRR and the importance of this pathway in maintaining chromosomal stability. ..
  30. The Risk of Cancer in Fanconi Anemia Heterozygotes
    Marianne Berwick; Fiscal Year: 2005
    ..Analyses will be undertaken to evaluate the role of Fanconi anemia heterozygosity for cancer. If carriers are found to be at increased risk, this information can be used to target individuals for cancer prevention strategies. ..
  31. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    ..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
  32. Gene Environment Interaction in Head and Neck Cancer
    Andrew Olshan; Fiscal Year: 2005
    ..The proposed study should contribute knowledge on gene-environment interactions for cancer of the head and neck, but also for other tobacco- and alcohol-related cancers and possibly cancers of unknown etiology. ..