XRCC2

Summary

Gene Symbol: XRCC2
Description: X-ray repair cross complementing 2
Alias: FANCU, DNA repair protein XRCC2, X-ray repair complementing defective repair in Chinese hamster cells 2, X-ray repair cross-complementing protein 2
Species: human

Top Publications

  1. ncbi Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents
    J Thacker
    MRC Radiobiology Unit, Chilton, Didcot, Oxon, UK
    Hum Mol Genet 4:113-20. 1995
  2. ncbi The XRCC2 DNA repair gene: identification of a positional candidate
    C E Tambini
    DNA Repair and Mutagenesis Group, MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire, United Kingdom
    Genomics 41:84-92. 1997
  3. ncbi Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study
    Jiali Han
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 25:189-95. 2004
  4. ncbi XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  5. ncbi Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer
    Penelope M Webb
    Population and Clinical Sciences Division, Queensland Institute of Medical Research and University of Queensland, Brisbane, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 14:319-23. 2005
  6. ncbi Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
    R D Johnson
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Nature 401:397-9. 1999
  7. ncbi The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2
    J P Braybrooke
    Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, Oxfordshire OX11 ORD, United Kingdom
    J Biol Chem 275:29100-6. 2000
  8. pmc Domain mapping of the Rad51 paralog protein complexes
    Kristi A Miller
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
    Nucleic Acids Res 32:169-78. 2004
  9. ncbi Polymorphisms in DNA double-strand break repair genes and skin cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 64:3009-13. 2004
  10. ncbi DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract
    Simone Benhamou
    INSERM and Evry University, EMI 00 06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France
    Int J Cancer 112:901-4. 2004

Research Grants

  1. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
  2. Nucleotide Excision Repair Gene Variants and Skin Cancer
    Jiali Han; Fiscal Year: 2005
  3. The Risk of Cancer in Fanconi Anemia Heterozygotes
    Marianne Berwick; Fiscal Year: 2005
  4. Solar Exposure and Melanoma Survival
    Marianne Berwick; Fiscal Year: 2009
  5. Lauren Endres; Fiscal Year: 2014
  6. Homologous Recombination in Genome Stability and Tumor Suppression
    Kevin D Mills; Fiscal Year: 2012
  7. Transferability of Tagging-SNPs across disease status: colon cancer and XRCC2
    NICOLA CAMP; Fiscal Year: 2007
  8. Homologous Recombination & Human Cell Radiosensitivity
    LAWRENCE THOMPSON; Fiscal Year: 2009
  9. Role of Rad51 Paralogs in Mammalian DNA Repair
    Patrick Sung; Fiscal Year: 2006
  10. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003

Detail Information

Publications175 found, 100 shown here

  1. ncbi Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents
    J Thacker
    MRC Radiobiology Unit, Chilton, Didcot, Oxon, UK
    Hum Mol Genet 4:113-20. 1995
    ..hybrids were analysed by Alu-PCR, chromosome painting, and with DNA markers to map the complementing gene (named XRCC2) to a specific chromosomal region...
  2. ncbi The XRCC2 DNA repair gene: identification of a positional candidate
    C E Tambini
    DNA Repair and Mutagenesis Group, MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire, United Kingdom
    Genomics 41:84-92. 1997
    The human XRCC2 gene, complementing a hamster cell line (irs1) hypersensitive to DNA-damaging agents, was previously mapped to chromosome 7q36.1...
  3. ncbi Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study
    Jiali Han
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 25:189-95. 2004
    ..We prospectively assessed the associations of candidate polymorphisms G31479A (R188H) in XRCC2, A4541G (5'-UTR), A17893G (IVS5-14) and C18067T (T241 M) in XRCC3, and C299T (5'-UTR) and T1977C (D501D) in Ligase ..
  4. ncbi XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  5. ncbi Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer
    Penelope M Webb
    Population and Clinical Sciences Division, Queensland Institute of Medical Research and University of Queensland, Brisbane, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 14:319-23. 2005
    ..design, whether the double-strand break repair gene polymorphisms RAD51 5' untranslated region -135 G > C, XRCC2 R188H G > A, and XRCC3 T241M C > T were associated with risk of breast or ovarian cancer in Australian women...
  6. ncbi Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
    R D Johnson
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Nature 401:397-9. 1999
    ..repair by homologous recombination on the basis of their sequence homology to yeast Rad51: one of these is human XRCC2. Here we show that XRCC2 is essential for the efficient repair of DNA double-strand breaks by homologous ..
  7. ncbi The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2
    J P Braybrooke
    Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, Oxfordshire OX11 ORD, United Kingdom
    J Biol Chem 275:29100-6. 2000
    ..We have identified a protein complex in human cells containing RAD51L3 and a second RAD51 family member, XRCC2. By using purified proteins, we demonstrate that the interaction between RAD51L3 and XRCC2 is direct...
  8. pmc Domain mapping of the Rad51 paralog protein complexes
    Kristi A Miller
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
    Nucleic Acids Res 32:169-78. 2004
    ..These proteins have been found to form two distinct complexes in vivo, Rad51B-Rad51C-Rad51D-Xrcc2 (BCDX2) and Rad51C-Xrcc3 (CX3)...
  9. ncbi Polymorphisms in DNA double-strand break repair genes and skin cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 64:3009-13. 2004
    ..We selected 11 haplotype-tagging single nucleotide polymorphisms in three DSB repair genes XRCC2, XRCC3, and LigaseIV and evaluated their associations with skin cancer risk in a nested case-control study within ..
  10. ncbi DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract
    Simone Benhamou
    INSERM and Evry University, EMI 00 06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France
    Int J Cancer 112:901-4. 2004
    ..Polymorphisms in XRCC2 and XRCC3 genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking-related ..
  11. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
    ..genes APE1/APEX, OGG1, MPG, XRCC1, PCNA, POLB, POLiota, LIG3 and EXO1; double-strand break repair (DSB-R) genes XRCC2, XRCC3, XRCC9, NBS1 and ATR; and direct damage reversal (DR) gene MGMT/AGT...
  12. ncbi Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk
    Robert C Millikan
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7400, Chapel Hill, NC 27599 7400, USA
    Cancer Epidemiol Biomarkers Prev 14:2326-34. 2005
    ..codon 241 Thr/Met, Nijmegen breakage syndrome 1 (NBS1) codon 185 Glu/Gln, X-ray cross-complementing group 2 (XRCC2) codon 188 Arg/His, and breast cancer susceptibility gene 2 (BRCH2) codon 372 Asn/His...
  13. ncbi Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study
    Giuseppe Matullo
    Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2569-78. 2005
    ..18067C>T; proliferating cell nuclear antigen (PCNA): 6084G>C; ERCC4: 30028C>T, 30147A>G; and XRCC2-31479A>G] in 317 incident bladder cancer patients and 317 controls...
  14. ncbi Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
    Hum Genet 119:376-88. 2006
    ..We evaluated the association between 19 polymorphisms in seven genes in this pathway (XRCC2, XRCC3, BRCA2, ZNF350, BRIP1, XRCC4, LIG4) and breast cancer risk in two population-based studies in USA (3,368 ..
  15. ncbi Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer
    Victor Moreno
    Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, Hospitalet, Barcelona, Spain
    Clin Cancer Res 12:2101-8. 2006
    ..We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of developing colorectal cancer and the prognosis of patients...
  16. ncbi A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage
    Patrick Danoy
    Centre for Genomic Medicine, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 352:763-8. 2007
    ..We established mutant cell lines complemented with either wild-type or variant cDNAs of three human genes, RAD51, XRCC2, and XRCC3, and assessed their sensitivity to cisplatin and mitomycin C...
  17. ncbi Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007
    ..and ZNF350), non-homologous end-joining (NHEJ) DNA repair (XRCC4) and homologous recombination (HR) repair (RAD51, XRCC2 and XRCC3). SNPs for RAD51 and XRCC2 covered most of the common variation...
  18. pmc XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Gastroenterol 103:360-7. 2008
    b>XRCC2 and XRCC3 are key components of the homologous recombination (HR) machinery that repairs DNA double-strand breaks...
  19. pmc Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set
    Jonathan Beesley
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007
    ..SNP) in genes involved in steroid hormone synthesis (SRD5A2, CYP19A1, HSB17B1, and HSD17B4) and DNA repair (XRCC2, XRCC3, BRCA2, and RAD52) using two Australian ovarian cancer case-control studies, comprising a total of 1,466 ..
  20. pmc International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways
    Rayjean J Hung
    IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 17:3081-9. 2008
    ..To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies...
  21. pmc Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium
    C L Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Br J Cancer 100:412-20. 2009
    ..10 in a log-additive model: rs2740574 in CYP3A4 (P=0.011), rs1805386 in LIG4 (P=0.007), and rs3218536 in XRCC2 (P=0.095)...
  22. pmc Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesis
    Karen Curtin
    Genetic Epidemiology, University of Utah School of Medicine, 391 Chipeta Way Suite D2, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 18:2476-84. 2009
    Polymorphisms in DNA double-strand break repair gene XRCC2 may play an important role in colorectal cancer etiology, specifically in disease subtypes...
  23. doi Association of polymorphisms in genes of the homologous recombination DNA repair pathway and thyroid cancer risk
    Helder Novais Bastos
    Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, P 1349 008 Lisbon, Portugal
    Thyroid 19:1067-75. 2009
    ..Since there is a scarcity of data about the involvement of these gene polymorphisms in thyroid cancer susceptibility, we carried out a case-control study in a Caucasian Portuguese population...
  24. doi XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects
    Ke Da Yu
    Department of Breast Surgery, Cancer Hospital Cancer Institute, Breast Cancer Institute, Fudan University, 399 Ling Ling Road, 200032 Shanghai, People s Republic of China
    Breast Cancer Res Treat 123:219-25. 2010
    Several common single-nucleotide polymorphisms (SNPs) within the XRCC2 gene have been identified as potential breast cancer susceptibility loci and a coding SNP in exon 3 (Arg188His, rs3218536) has been extensively studied, though the ..
  25. doi The importance of XRCC2 in RAD51-related DNA damage repair
    Cathryn E Tambini
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxon OX11 0RD, United Kingdom
    DNA Repair (Amst) 9:517-25. 2010
    ..Several RAD51-like proteins, including XRCC2, appear to help with this process, but their roles are not well understood...
  26. pmc Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study
    Renata Krupa
    Laboratory of DNA Repair, Department of Molecular Genetics, University of Lodz, and Department of Surgical Oncology, N Copernicus Hospital, Banacha 12 16, 90 237, Lodz, Poland
    Mol Biol Rep 38:2849-54. 2011
    b>XRCC2 and XRCC3 proteins are structurally and functionally related to RAD51 which play an important role in the homologous recombination, the process frequently involved in cancer transformation...
  27. doi DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome
    Stuart G Reeves
    Discipline of Medical Genetic, Faculty of Health, University of Newcastle, NSW, Australia
    Cancer Epidemiol 36:183-9. 2012
    ..in the study were: BRCA2 (rs11571653), MSH3 (rs26279), Lig4 (rs1805386), OGG1 (rs1052133), XRCC1 (rs25487), XRCC2 (rs3218536 and rs1799793) and XRCC3 (rs861539)...
  28. ncbi The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland
    H Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Eur J Gynaecol Oncol 33:145-50. 2012
    b>XRCC2 and XRCC3 genes are structurally and functionally related to RAD51 which plays an important role in homologous recombination, the process frequently involved in cancer transformation.
  29. pmc Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway
    Jarin Chun
    Molecular Biology Program and Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Mol Cell Biol 33:387-95. 2013
    ..The Rad51 paralogs associate with one another in two distinct complexes: Rad51B-Rad51C-Rad51D-XRCC2 (BCDX2) and Rad51C-XRCC3 (CX3). We find that the BCDX2 and CX3 complexes act at different stages of the HR pathway...
  30. pmc Identification and purification of two distinct complexes containing the five RAD51 paralogs
    J Y Masson
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Genes Dev 15:3296-307. 2001
    Cells defective in any of the RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) are sensitive to DNA cross-linking agents and to ionizing radiation...
  31. ncbi Defective DNA mismatch repair and XRCC2 mutation in uterine carcinosarcomas
    Nicholas P Taylor
    Department of Ob Gyn, Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, Maternity Building, 3rd Floor, St Louis, MO 63110, USA
    Gynecol Oncol 100:107-10. 2006
    A frameshift mutation in the double-strand breakage repair gene XRCC2 was identified in a mismatch repair (MMR) deficient cell line derived from a uterine carcinosarcoma...
  32. doi Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination
    Hatsumi Nagasawa
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 7:515-22. 2008
    ..present study, we examined additional Chinese hamster cell lines deficient in the Rad51 paralogs Rad51C, Rad51D, Xrcc2, and Xrcc3 as well as another essential HRR protein, Brca2...
  33. ncbi Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation
    J E Sale
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 412:921-6. 2001
    ..Here we show that if the RAD51 paralogues XRCC2, XRCC3 or RAD51B are ablated the pattern of diversification of the immunoglobulin V gene in the chicken DT40 B-..
  34. pmc RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regions
    Ellen C Ordinario
    Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98195 7650, USA
    BMC Mol Biol 10:98. 2009
    ....
  35. pmc Unventilated indoor coal-fired stoves in Guizhou province, China: cellular and genetic damage in villagers exposed to arsenic in food and air
    Aihua Zhang
    Department of Toxicology, School of Public Health, Guiyang Medical University, 9 Beijing Road, Guiyang City, 550004 Guizhou Province, People s Republic of China
    Environ Health Perspect 115:653-8. 2007
    ..Because the poisoning mechanism involved in arsenicosis is as yet unknown and no effective therapy exists, progress has been slow on the prevention and therapy of arsenicosis...
  36. pmc Detection of novel recombinases in bacteriophage genomes unveils Rad52, Rad51 and Gp2.5 remote homologs
    Anne Lopes
    CEA, iBiTecS, F 91191 Gif sur Yvette, France
    Nucleic Acids Res 38:3952-62. 2010
    ..Screening for these recombinases in genomes can be performed at http://biodev.extra.cea.fr/virfam...
  37. pmc Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination
    Muneer G Hasham
    The Jackson Laboratory, Bar Harbor, ME, USA
    Nat Immunol 11:820-6. 2010
    ..We demonstrate that the homologous-recombination factor XRCC2 suppressed AID-induced off-target DSBs, promoting B cell survival...
  38. doi Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiple genotype-phenotype study
    Ruo Chia Tseng
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Cancer 115:2939-48. 2009
    ..The authors of this report postulated that polymorphisms in genes of the nonhomologous end-joining (NHEJ) pathway, which is the major DSB repair pathway in mammalian cells, may modulate lung cancer susceptibility and prognosis...
  39. ncbi Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer
    Sambasivarao Damaraju
    Cross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 12:2545-54. 2006
    ....
  40. pmc Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair
    Linda Savolainen
    Department of Genetics, Microbiology and Toxicology, Arrhenius Laboratory, Stockholm University, S 106 91 Stockholm, Sweden
    Nucleic Acids Res 37:405-12. 2009
    ..It is well established that both the BRCA2 protein and the RAD51 paralog protein XRCC2 are required for homologous recombination...
  41. ncbi Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion
    Catherine A French
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, England
    J Biol Chem 278:45445-50. 2003
    ..Therefore we have identified protein domains that are important for the correct functioning of RAD51L2 and have shown that there is a specific requirement for RAD51L2 in gene conversion in mammalian cells...
  42. ncbi Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice
    Bryan Deans
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire, United Kingdom
    Cancer Res 63:8181-7. 2003
    ..b>Xrcc2 is a protein with homology to Rad51, the core component of HR, but with a nonredundant role in damage repair...
  43. ncbi Human Rad51C deficiency destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells
    Yi Ching Lio
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 279:42313-20. 2004
    ..In vertebrates, five Rad51 paralogs (Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3) are expressed in mitotically growing cells and are thought to play mediating roles in homologous ..
  44. ncbi The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells
    Carol Griffin
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, England, UK
    DNA Repair (Amst) 4:1019-27. 2005
    ..We chose cells deficient in Ku70 (DNA end joining), Xrcc2 (gene conversion), Ercc1 (single-strand annealing) and Csb (transcription-coupled repair) to represent potentially-..
  45. ncbi Transcriptome analysis of differentiating spermatogonia stimulated with kit ligand
    Pellegrino Rossi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Gene Expr Patterns 8:58-70. 2008
    ..spermatogonia the expression of early meiotic genes (for instance: Lhx8, Nek1, Rnf141, Xrcc3, Tpo1, Tbca, Xrcc2, Mesp1, Phf7, Rtel1), whereas it down-regulates typical spermatogonial markers (for instance: Pole, Ptgs2, Zfpm2, ..
  46. ncbi Identification of novel pathogen-responsive cis-elements and their binding proteins in the promoter of OsWRKY13, a gene regulating rice disease resistance
    Meng Cai
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Cell Environ 31:86-96. 2008
    ..These proteins localize in the nucleus and show differential expression upon pathogen challenge. These results suggest that OsWRKY13 expression is regulated by multiple factors to achieve disease resistance...
  47. pmc Interaction of p53 with the human Rad51 protein
    S Buchhop
    Institut für Humangenetik Universität zu Lübeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Nucleic Acids Res 25:3868-74. 1997
    ..These data are consistent with the hypothesis that p53 interaction with hRAD51 may influence DNA recombination and repair and that additional modifications of p53 by mutation and protein binding may affect this interaction...
  48. pmc Functional characterization and identification of mouse Rad51d splice variants
    Aaron M Gruver
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina Campus, Columbia, SC 29208, USA
    BMC Mol Biol 10:27. 2009
    ..The RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3) are essential for this process in vertebrates, and the RAD51D paralog is unique in that it participates in ..
  49. ncbi Molecular cloning and characterization of RAD51-like genes from Arabidopsis thaliana
    Keishi Osakabe
    Department of Plant Biotechnology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Plant Mol Biol 50:71-81. 2002
    ..The results of yeast two-hybrid assays suggested that Arabidopsis Rad51 family proteins form a complex, which could participate in meiotic recombination and/or homologous recombinational repair...
  50. pmc The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis
    Jean Yves Bleuyard
    CNRS UMR6547, Universite Blaise Pascal, Aubiere, France
    EMBO J 23:439-49. 2004
    ..proteins have been identified from yeast (Rad55, Rad57 and Dmc1) to vertebrates (Rad51B, Rad51C, Rad51D, Xrcc2, Xrcc3 and Dmc1)...
  51. ncbi Differential roles of XRCC2 in homologous recombinational repair of stalled replication forks
    Nan Liu
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    J Cell Biochem 95:942-54. 2005
    ..In this study, we investigated the role of XRCC2, a member of the RAD51 paralog family, in cellular recovery from replication arrest via homologous recombination...
  52. pmc Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination
    Claudia Wiese
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Nucleic Acids Res 34:2833-43. 2006
    In vertebrates, homologous recombinational repair (HRR) requires RAD51 and five RAD51 paralogs (XRCC2, XRCC3, RAD51B, RAD51C and RAD51D) that all contain conserved Walker A and B ATPase motifs...
  53. ncbi Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C
    C S Leasure
    Mouse Cancer Genetics Program, National Cancer Institute at Frederick, P O Box B, Frederick, MD 21702, USA
    Gene 271:59-67. 2001
    ..The murine Rad51l2 gene maps to chromosome 11 and is located in the syntenic region of human chromosome 17q22-23, where the human RAD51L2 is present...
  54. pmc Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability
    Barbara C Godthelp
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    Nucleic Acids Res 30:2172-82. 2002
    ..Five paralogs of Rad51 have been identified in vertebrates, Rad51B, Rad51C, Rad51D, Xrcc2 and Xrcc3, which are also implicated in recombination and genome stability...
  55. ncbi Identification of the subunit-subunit interface of Xenopus Rad51.1 protein: similarity to RecA
    Tassadite Selmane
    FRE 2230 Unité de Recherche sur la Biocatalyse, Centre National de la Recherche Scientifique and University of Nantes, 2 rue de la Houssiniere, 44322 Nantes Cedex 3, France
    J Mol Biol 335:895-904. 2004
    ..Thus, Rad51 forms filaments by subunit-subunit contact much like RecA does...
  56. ncbi The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C
    Aaron M Gruver
    Department of Physiology and Cardiovascular Genomics, Medical University of Ohio, Toledo, OH 43614 5804, USA
    Mutagenesis 20:433-40. 2005
    ..In mammals, HR requires the activities of the RAD51 family (RAD51, RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 and DMC1), each of which contains conserved ATP binding sequences (Walker Motifs A and B)...
  57. doi Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells
    James W Evans
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 68:257-65. 2008
    ..role in repair of tirapazamine-induced damage because cells defective in homologous recombination proteins XRCC2, XRCC3, Rad51D, BRCA1, or BRCA2 are particularly sensitive to tirapazamine...
  58. pmc Homologous recombination is necessary for normal lymphocyte development
    Lura B Caddle
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Mol Cell Biol 28:2295-303. 2008
    ..We have investigated roles of the X-ray cross-complementing 2 (Xrcc2) HR gene in lymphocyte development...
  59. ncbi Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ
    Wenqi Wu
    Institute of Medical Radiation Biology, University of Duisburg Essen Medical School, Essen, Germany
    Radiat Res 170:512-20. 2008
    ..studies to Chinese hamster mutant cells with defects in the DNA-PKcs, Ku80 or XRCC4 components of D-NHEJ or in the XRCC2 and XRCC3 components of HRR...
  60. pmc Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice
    Sergey G Kuznetsov
    Mouse Cancer Genetics Program, Center for Cancer Research, Science Applications International Corporation Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cancer Res 69:863-72. 2009
    RecA/Rad51 protein family members (Rad51, Rad51b, Rad51c, Rad51d, Xrcc2, and Xrcc3) are essential for DNA repair by homologous recombination, and their role in cancers has been anticipated...
  61. doi The interaction profile of homologous recombination repair proteins RAD51C, RAD51D and XRCC2 as determined by proteomic analysis
    Changanamkandath Rajesh
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Proteomics 9:4071-86. 2009
    ..To identify candidates that interact with HR proteins, the mouse RAD51C, RAD51D and XRCC2 proteins were purified using bacterial expression systems and each of them used to co-precipitate interacting ..
  62. ncbi Colorectal cancer and genetic polymorphism of DNA double-strand break repair gene XRCC4 in Taiwan
    Da Tian Bau
    Terry Fox Cancer Research Lab, China Medical University Hospital, 2 Yuh Der Road, Taichung, 404 Taiwan, R O C
    Anticancer Res 30:2727-30. 2010
    ..We conclude that the G allele of XRCC4 G-1394T may contribute to colorectal carcinogenesis and may be useful for early detection of colorectal cancer...
  63. pmc The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51
    J Y Masson
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    EMBO J 18:6552-60. 1999
    ..Consistent with the requirement for two recombinases in meiotic recombination, hDmc1 interacts directly with hRad51...
  64. ncbi Aneuploidy, centrosome activity and chromosome instability in cells deficient in homologous recombination repair
    Carol S Griffin
    Radiation and Genome Stability Unit, Medical Research Council, Oxon, Harwell, UK
    Mutat Res 504:149-55. 2002
    ..We have recently shown that hamster cell lines deficient in homologous recombination repair (HRR) genes XRCC2 and XRCC3 have an elevated frequency of aneuploidy compared with wild-type cells and mutant cells transfected with ..
  65. ncbi Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro
    Yi Ching Lio
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 278:2469-78. 2003
    ..In addition to Rad51 protein, five paralogs have been identified: Rad51B/Rad51L1, Rad51C/Rad51L2, Rad51D/Rad51L3, XRCC2, and XRCC3...
  66. ncbi Nuclear localization of Rad51B is independent of Rad51C and BRCA2
    Kristi A Miller
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
    Mutagenesis 20:57-63. 2005
    ..paralogs of human Rad51 and is found in a multiprotein complex with three other Rad51 paralogs, Rad51C, Rad51D and Xrcc2. Participation of Rad51B in this complex depends on its direct interaction with Rad51C...
  67. ncbi Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2
    Shobbir Hussain
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s Hospital, London SE1 9RT, UK
    DNA Repair (Amst) 5:629-40. 2006
    ..We therefore tested known FA proteins for direct interaction with RAD51 and its paralogs XRCC2 and XRCC3...
  68. pmc Sws1 is a conserved regulator of homologous recombination in eukaryotic cells
    Victoria Martin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 25:2564-74. 2006
    ..complex with Rlp1 and Rdl1, two RecA-like proteins that are most closely related to the human Rad51 paralogs XRCC2 and RAD51D, respectively. This finding indicates that the XRCC2-RAD51D complex is conserved in lower eukaryotes...
  69. doi Artesunate derived from traditional Chinese medicine induces DNA damage and repair
    Paul C H Li
    Institute of Toxicology, University of Mainz, Mainz, Germany
    Cancer Res 68:4347-51. 2008
    ..irs1 and VC8 cells defective in homologous recombination (HR) due to inactivation of XRCC2 and BRCA2, respectively, were more sensitive to artesunate than the corresponding wild-type...
  70. doi A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility
    Paolo Vineis
    Department of Epidemiology and Public Health, Imperial College, London, UK
    J Natl Cancer Inst 101:24-36. 2009
    ..Although efforts have been made to create synopses for specific fields that summarize the data from genetic association studies, such an overview is not available for genes involved in DNA repair...
  71. pmc Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy
    Ming Yin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e20055. 2011
    ..e., RAD51 -135G>C/rs1801320 and -172G>T/rs1801321, XRCC2 4234G>C/rs3218384 and R188H/rs3218536 G>A, XRCC3 T241M/rs861539 and NBN E185Q/rs1805794) and estimated their ..
  72. ncbi Single nucleotide polymorphisms in the homologous recombination repair genes and breast cancer risk in Polish women
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Tohoku J Exp Med 224:201-8. 2011
    ..The polymorphisms studied were G135C of the RAD51 gene (c. -98 G>C; rs1801320), Arg188His of the XRCC2 gene (c. 563 G>A; rs3218536), and Thr241Met of the XRCC3 gene (c. 722 C>T; rs861539)...
  73. doi Single nucleotide polymorphisms of RAD51 G135C, XRCC2 Arg188His and XRCC3 Thr241Met homologous recombination repair genes and the risk of sporadic endometrial cancer in Polish women
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Medical University of Lodz, Lodz, Poland
    J Obstet Gynaecol Res 38:918-24. 2012
    The genes RAD51, XRCC2 and XRCC3 encode proteins that are important for the repair of double-strand DNA breaks by homologous recombination...
  74. doi Influence of DNA repair gene polymorphisms on prognosis in inoperable non-small cell lung cancer patients treated with radiotherapy and platinum-based chemotherapy
    Dorota Butkiewicz
    Center For Translational Research and Molecular Biology of Cancer, M Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44 101 Gliwice, Poland
    Int J Cancer 131:E1100-8. 2012
    ..this study, we analyzed the association between the XPA -4G>A, XPD Asp312Asn, hOGG1 Ser326Cys, XRCC1 Arg399Gln, XRCC2 -4234G>C, XRCC3 -4541A>G and Thr241Met polymorphisms and prognosis in 250 inoperable non-small cell lung ..
  75. doi Combining heavy ion radiation and artificial microRNAs to target the homologous recombination repair gene efficiently kills human tumor cells
    Zhiming Zheng
    Department of Neurosurgery, Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, China
    Int J Radiat Oncol Biol Phys 85:466-71. 2013
    ..that our designed artificial microRNAs (amiRs) could efficiently target XRCC4 (an essential factor for NHEJ) or XRCC2 (an essential factor for HRR) and sensitize human tumor cells to X-rays...
  76. pmc ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair
    Kumar Somyajit
    Department of Biochemistry, Indian Institute of Science, Bangalore, India
    Mol Cell Biol 33:1830-44. 2013
    ..We find that RAD51C but not XRCC2 is essential for XRCC3 phosphorylation, and this modification follows end resection and is specific to S and G2 ..
  77. pmc Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair
    J Y Park
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH, USA
    Oncogene 33:4803-12. 2014
    ..Together, our results suggest that three different cancer susceptibility and FA proteins function in a DNA repair pathway based upon the PALB2 WD40 domain binding to RAD51C and BRCA2. ..
  78. doi The effect of RAD51 135 G>C and XRCC2 G>A (rs3218536) polymorphisms on ovarian cancer risk among Caucasians: a meta-analysis
    Shujing Shi
    Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, People s Republic of China
    Tumour Biol 35:5797-804. 2014
    Genetic polymorphisms of RAD51 135 G>C and XRCC2 G>A (rs3218536) have been reported to change the risk of ovarian cancer, but the results are controversial. To get a more precise result, a meta-analysis was performed...
  79. doi Impairment of the non-homologous end joining and homologous recombination pathways of DNA double strand break repair: Impact on spontaneous and radiation-induced mammary and intestinal tumour risk in Apc min/+ mice
    Jackie W Haines
    Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxon OX11 0RQ, UK
    DNA Repair (Amst) 35:19-26. 2015
    Female Apc(min/+) mice carrying the BALB/c variant of Prkdc or heterozygous knockout for Xrcc2, were sham- or 2 Gy X-irradiated as adults to compare the effect of mild impairments of double-strand break (DSB) repair pathways, non-..
  80. doi DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis
    R B Ji
    Liver Disease Research Center, Ningbo No 2 Hospital, Ningbo, Zheijiang, China
    Genet Mol Res 14:15988-96. 2015
    ..27, 95%CI = 0.99-1.62). In a subgroup analysis by sample size (number of subjects > 1000), similar results were obtained. Thus, XRCC3 T241M polymorphism may constitute a risk factor for HCC in the Chinese population. ..
  81. doi miR-3940-5p enhances homologous recombination after DSB in Cr(VI) exposed 16HBE cell
    Yang Li
    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, China
    Toxicology 344:1-6. 2016
    ..chromium (Cr(VI)) downregulated plasma miR-3940-5p level, and a low miR-3940-5p level was associated with high XRCC2 expression in lymphocytes, indicating that miR-3940-5p maybe play a protective effect in Cr(VI) induced DNA damage...
  82. ncbi Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes
    Kun Liu
    Department of Neurosurgery, The Second Xiangya Hospital of Central South University, 139 Renmin M Road, Changsha, 410011, Hunan, China
    Cell Mol Neurobiol . 2016
    ....
  83. pmc RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity
    Brian D Yard
    Department of Translational Hematology and Oncology Research, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 44195, USA
    DNA Repair (Amst) 42:82-93. 2016
    ..Presence of RNF138 also enhanced the interaction between RAD51D and a known interacting RAD51 family member XRCC2 in a yeast three-hybrid assay...
  84. doi Functional Analysis of Missense Variants in the Putative Breast Cancer Susceptibility Gene XRCC2
    Florentine S Hilbers
    Department of Human Genetics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands
    Hum Mutat 37:914-25. 2016
    b>XRCC2 genetic variants have been associated with breast cancer susceptibility...
  85. pmc Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer
    Wei Zhang
    Department of Gynecology, Nanjing Medical University, Affiliated Hangzhou Hospital, Hangzhou First People s Hospital, 310006, Hangzhou, China
    Oncotarget 7:86621-86629. 2016
    Recent studies explored XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer (OC) risk. However, the association between these two single nucleotide polymorphisms and OC risk remains conflicting...
  86. ncbi Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3
    John M Hinz
    Institute for Cancer Studies, University of Sheffield School of Medicine, Beech Hill Road, Sheffield S10 2RX, UK
    Carcinogenesis 24:249-53. 2003
    ..In the work reported here we investigated the possible role of the Rad51-like HR proteins XRCC2, XRCC3 and Rad51C in apoptosis following the induction of DSBs by camptothecin...
  87. ncbi Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks
    Huichen Wang
    Department of Radiation Oncology of Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Oncogene 23:824-34. 2004
    We recently reported that two Chinese hamster mutants deficient in the RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus implicating homology-directed repair (HDR) of DNA double-strand ..
  88. ncbi Genetic variations in XRCC2 and XRCC3 are not associated with endometrial cancer risk
    Jiali Han
    Department of Nutrition and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:330-1. 2004
  89. ncbi A hot spot for RAD51C interactions revealed by a peptide that sensitizes cells to cisplatin
    Philip P Connell
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 64:3002-5. 2004
    ..The paralogs form two complexes in solution, a XRCC3/RAD51C heterodimer and a RAD51B/RAD51C/RAD51D/XRCC2 heterotetramer...
  90. ncbi Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide
    Roman Tsaryk
    Institute of Toxicology, University of Mainz, Obere Zahlbacher Street 67, D 55131 Mainz, Germany
    Cancer Lett 239:305-13. 2006
    ..DSBs are repaired by non-homologous end-joining and homologous recombination (HR). A key player in HR is Xrcc2, a Rad51-like protein...
  91. doi Effects of XRCC2 and RAD51B mutations on somatic and meiotic recombination in Arabidopsis thaliana
    Olivier Da Ines
    Genetique, Reproduction et Développement, UMR CNRS 6293, Clermont Universite, INSERM U1103, 63171, Aubiere, France
    Plant J 74:959-70. 2013
    ..assays and immunocytology confirm that the three 'non-meiotic' paralogues of Arabidopsis, RAD51B, RAD51D and XRCC2, are involved in somatic homologous recombination, and that they are not required for the formation of ..
  92. doi Polymorphisms in double-strand breaks repair genes are associated with impaired fertility in Chinese population
    Guixiang Ji
    Nanjing Institute of Environmental Sciences Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Environmental Protection, Nanjing 210042, People s Republic of China
    Reproduction 145:463-70. 2013
    ..susceptibility to male infertility, we examined 11 single nucleotide polymorphisms in eight key DSBs genes (XRCC3, XRCC2, BRCA2, RAG1, XRCC5, LIG4, XRCC4 and ATM) in 580 infertility cases and 580 controls from a Chinese population-..
  93. pmc No association between DNA repair gene XRCC1 and amyotrophic lateral sclerosis
    Fang Fang
    Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    Neurobiol Aging 33:1015.e25-6. 2012
    ..Our results did not show any differences in the frequency of XRCC1 gene polymorphisms between ALS patients and controls free of any neurological disease...
  94. doi RNAi-mediated targeting of noncoding and coding sequences in DNA repair gene messages efficiently radiosensitizes human tumor cells
    Zhiming Zheng
    Department of Neurosurgery, Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, China
    Cancer Res 72:1221-8. 2012
    ..In this study, we show that combining an artificial miRNA (amiR) engineered to target 3'-untranslated regions of XRCC2 (an HRR factor) or XRCC4 (an NHEJ factor) along with an siRNA to target the gene coding region can improve ..
  95. doi Single nucleotide polymorphism barcoding to evaluate oral cancer risk using odds ratio-based genetic algorithms
    Cheng Hong Yang
    Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 28:362-8. 2012
    ..between four SNPs-namely rs1799782, rs2040639, rs861539, rs2075685, and belonging to four genes (XRCC1, XRCC2, XRCC3, and XRCC4)-were tested in this study, respectively...
  96. doi Rare variants in XRCC2 as breast cancer susceptibility alleles
    Florentine S Hilbers
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    J Med Genet 49:618-20. 2012
    Recently, rare germline variants in XRCC2 were detected in non-BRCA1/2 familial breast cancer cases, and a significant association with breast cancer was reported...
  97. pmc RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study
    Florence Le Calvez-Kelm
    Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France
    PLoS ONE 7:e52374. 2012
    ..and despite the fact that rare, likely dysfunctional variants in three of its five paralogs, RAD51C, RAD51D, and XRCC2, have been associated with breast and/or ovarian cancer risk, no population-based case-control mutation screening ..
  98. pmc Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Arch Med Sci 8:1065-75. 2012
    ..In the present work we investigated the association between polymorphisms of two HRR genes, XRCC2 and RAD51, and tobacco- and alcohol-related larynx cancer in a Polish population.
  99. pmc Characterization of strand exchange activity of yeast Rad51 protein
    E Namsaraev
    Department of Biochemistry, Beckman Center for Molecular and Genetic Medicine, School of Medicine, Stanford University, California 94305, USA
    Mol Cell Biol 17:5359-68. 1997
    ..Joint molecules formed via the 5' end are processed by branch migration in the 3'-to-5' direction with respect to ssDNA, and joint molecules formed with a 3' end are processed in the opposite direction...
  100. pmc The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family
    R Cartwright
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, UK
    Nucleic Acids Res 26:3084-9. 1998
    We recently identified a positional candidate for the XRCC2 DNA repair gene at human chromosome 7q36.1...

Research Grants21

  1. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    ..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
  2. Nucleotide Excision Repair Gene Variants and Skin Cancer
    Jiali Han; Fiscal Year: 2005
    ..abstract_text> ..
  3. The Risk of Cancer in Fanconi Anemia Heterozygotes
    Marianne Berwick; Fiscal Year: 2005
    ..Analyses will be undertaken to evaluate the role of Fanconi anemia heterozygosity for cancer. If carriers are found to be at increased risk, this information can be used to target individuals for cancer prevention strategies. ..
  4. Solar Exposure and Melanoma Survival
    Marianne Berwick; Fiscal Year: 2009
    ..2. Determine whether functional polymorphic variants in the vitamin D receptor affect survival from melanoma. 3. Investigate the interaction of lifetime solar exposure and polymorphisms in VDR and its effect on survival. ..
  5. Lauren Endres; Fiscal Year: 2014
    ..e., for SSBR, PARP, XRCC1 and polynucleotide kinase;for DSBR, RAD family proteins, XRCC2 and 3, BRCA1 and 2, Ku70 and 86, and DNAPK)...
  6. Homologous Recombination in Genome Stability and Tumor Suppression
    Kevin D Mills; Fiscal Year: 2012
    ..We will test this hypothesis by focusing on the function of one important HR pathway component, XRCC2, in lymphocytes...
  7. Transferability of Tagging-SNPs across disease status: colon cancer and XRCC2
    NICOLA CAMP; Fiscal Year: 2007
    ..robustness of the assumption that a neutral sequencing panel is adequate for tSNP selection using real data for XRCC2 and colorectal cancer status as well as simulated data...
  8. Homologous Recombination & Human Cell Radiosensitivity
    LAWRENCE THOMPSON; Fiscal Year: 2009
    ..In non-human vertebrate cells, mutations in the Rad51 paralogs (XRCC2/3 &Rad51B/C/D) confer similar phenotypes of moderate IR sensitivity and high chromosome instability...
  9. Role of Rad51 Paralogs in Mammalian DNA Repair
    Patrick Sung; Fiscal Year: 2006
    ..Interestingly, in vertebrate cells, five Rad51-like proteins -XRCC2, XRCC3, Rad51B, Rad51C, and Rad51C- commonly called Rad51 paralogs, have been identified...
  10. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003
    ..CYP2C9, CYP2C19, CYP3A4, thiopurine methyltransferase, methylguanine DNA methyltransferase, ERCC1, XPD, XRCC1, XRCC2, XRCC3, XRCC4 and XRCC5...
  11. The roles of XPF/ERCC1 complex in DNA repair
    Tadayoshi Bessho; Fiscal Year: 2007
    ..The genetic data also indicate the involvement of XRCC2 and XRCC3 in XL repair...
  12. BIOLOGICAL FUNCTION OF XRCC2 IN RECOMBINATIONAL REPAIR
    Nan Liu; Fiscal Year: 2003
    ..The human XRCC2 protein is implicated in HRR by the properties of the IR-sensitive XRCC2 mutant irs1 and the finding that is ..
  13. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  14. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2010
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  15. Genetic Variants in Immunological Mediator Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying individuals at high-risk for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  16. Genetic Variants in Pigmentation Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2008
    ..This research will contribute to the scientific basis for identifying high-risk individuals for skin cancer and providing individualized risk management strategies. [unreadable] [unreadable] [unreadable]..
  17. Remodeling of Telomeres by Telomere Associated Proteins
    SARAH COMPTON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. ANALYSIS OF HUMAN RAD51 RELATED PROTEINS
    David Schild; Fiscal Year: 2001
    ..In human cells, six proteins in this family (HsRad51, XRCC2, XRCC3, Rad51B/hRec2, Rad51C and Rad51D) likely participate in recombinatorial repair and in maintaining genomic ..
  19. Prospective Study of DNA Repair Gene Variants in Breast Cancer
    Jiali Han; Fiscal Year: 2009
    ..This innovative work is essential to advance this field, and it has substantial potential for application to other areas of cancer susceptibility. ..
  20. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  21. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..