WT1

Summary

Gene Symbol: WT1
Description: Wilms tumor 1
Alias: AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor protein, Wilms tumor protein isoform Ex4a(+)
Species: human

Top Publications

  1. pmc The Wilms' tumor gene Wt1 is required for normal development of the retina
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat, Berlin, Germany
    EMBO J 21:1398-405. 2002
  2. pmc Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
    Silvestre Vicent
    Cancer Biology Program, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 120:3940-52. 2010
  3. doi Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study
    Daniela Cilloni
    Department of Clinical and Biological Sciences, University of Turin, Turin
    J Clin Oncol 27:5195-201. 2009
  4. ncbi Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus
    K M Call
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Cell 60:509-20. 1990
  5. doi Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion
    Maria V Barbolina
    Department of Chemical and Biological Engineering, Northwestern University, Chicago, Illinois, USA
    Cancer 112:1632-41. 2008
  6. ncbi Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
    M Gessler
    Genetics Division, Children s Hospital, Boston, Massachusetts
    Nature 343:774-8. 1990
  7. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
  8. doi Wilms tumor-1, claudin-1 and ezrin are useful immunohistochemical markers that help to distinguish schwannoma from fibroblastic meningioma
    Avninder Singh
    Safdarjung Hospital Campus, National Institute of Pathology ICMR, Room 602, 6th Floor, New Delhi, 110029, India
    Pathol Oncol Res 18:383-9. 2012
  9. pmc Repression of transcription by WT1-BASP1 requires the myristoylation of BASP1 and the PIP2-dependent recruitment of histone deacetylase
    Eneda Toska
    Department of Biological Sciences, University at Buffalo, Buffalo, NY 14260, USA
    Cell Rep 2:462-9. 2012
  10. pmc WT1 promotes cell proliferation in non-small cell lung cancer cell lines through up-regulating cyclin D1 and p-pRb in vitro and in vivo
    Caihua Xu
    Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China
    PLoS ONE 8:e68837. 2013

Research Grants

  1. Conditional Knockout of WT1 in Sertoli Cells In Vivo
    Michelle Barton; Fiscal Year: 2007
  2. Targeting DNA Secondary Structures for Bcl-2 Gene Regulation
    Danzhou Yang; Fiscal Year: 2013
  3. RNA Targets of the Wilm's Tumor Protein in the Kidney
    Russ Carstens; Fiscal Year: 2005
  4. WILLIAM TSWENCHING PU; Fiscal Year: 2016
  5. GLYCOLYTIC & PEROXISOMAL GENES ON CHROMOSOME 11 AND 12
    GAIL BRUNS; Fiscal Year: 1993
  6. Functional Characterization of WTX in Renal Development
    MIGUEL NICOLAS RIVERA; Fiscal Year: 2011
  7. GENES, CHROMOSOMAL REGIONS AND DEVELOPMENTAL DISORDERS
    GAIL BRUNS; Fiscal Year: 2000
  8. Wendy M Leisenring; Fiscal Year: 2016
  9. ERIC ALEJANDRO SWEET-CORDERO; Fiscal Year: 2016
  10. Analysis of Expression and LOH in Trout Nephroblastomas
    Gary Thorgaard; Fiscal Year: 2003

Detail Information

Publications274 found, 100 shown here

  1. pmc The Wilms' tumor gene Wt1 is required for normal development of the retina
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat, Berlin, Germany
    EMBO J 21:1398-405. 2002
    The Wilms' tumor gene Wt1 is known for its important functions during genitourinary and mesothelial formation. Here we show that Wt1 is necessary for neuronal development in the vertebrate retina...
  2. pmc Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
    Silvestre Vicent
    Cancer Biology Program, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 120:3940-52. 2010
    ..of functional genomics and mouse genetics, we identified a role for the transcription factor Wilms tumor 1 (WT1) as a critical regulator of senescence and proliferation downstream of oncogenic KRAS signaling...
  3. doi Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study
    Daniela Cilloni
    Department of Clinical and Biological Sciences, University of Turin, Turin
    J Clin Oncol 27:5195-201. 2009
    ..One proposed marker is the Wilms tumor gene WT1, which is overexpressed in most patients with AML, thus providing a putative target for immunotherapy, although in ..
  4. ncbi Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus
    K M Call
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Cell 60:509-20. 1990
    ..The genetic localization of this gene, its tissue-specific expression, and the function predicted from its sequence lead us to suggest that it represents the 11p13 Wilms' tumor gene...
  5. doi Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion
    Maria V Barbolina
    Department of Chemical and Biological Engineering, Northwestern University, Chicago, Illinois, USA
    Cancer 112:1632-41. 2008
    ..Metastasizing ovarian carcinoma cells encounter a collagen-rich microenvironment because the submesothelial matrix is comprised mainly of interstitial collagens Types I and III...
  6. ncbi Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
    M Gessler
    Genetics Division, Children s Hospital, Boston, Massachusetts
    Nature 343:774-8. 1990
    ..analysis has identified chromosome 11p13 as the smallest overlap region for deletions found in individuals with WAGR syndrome, which includes Wilms tumour (a recessive childhood nephroblastoma), aniridia, genito-urinary ..
  7. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    The Wilms' Tumour gene WT1 has important functions during development. Knock-out mice were shown to have defects in the urogenital system and to die at embryonic day E13.5, probably due to heart failure...
  8. doi Wilms tumor-1, claudin-1 and ezrin are useful immunohistochemical markers that help to distinguish schwannoma from fibroblastic meningioma
    Avninder Singh
    Safdarjung Hospital Campus, National Institute of Pathology ICMR, Room 602, 6th Floor, New Delhi, 110029, India
    Pathol Oncol Res 18:383-9. 2012
    ..000), <. 001], Claudin-1 [0.857(0.782, 0.932), <0.001] and ezrin [0.792(0.700,0.884),<0.001]. WT-1, Claudin-1 and Ezrin may be potentially useful immunohistochemical adjuncts to EMA and S100 that differentiate SCHW from FM...
  9. pmc Repression of transcription by WT1-BASP1 requires the myristoylation of BASP1 and the PIP2-dependent recruitment of histone deacetylase
    Eneda Toska
    Department of Biological Sciences, University at Buffalo, Buffalo, NY 14260, USA
    Cell Rep 2:462-9. 2012
    The Wilms' tumor 1 protein WT1 is a transcriptional regulator that is involved in cell growth and differentiation. The transcriptional corepressor BASP1 interacts with WT1 and converts WT1 from a transcriptional activator to a repressor...
  10. pmc WT1 promotes cell proliferation in non-small cell lung cancer cell lines through up-regulating cyclin D1 and p-pRb in vitro and in vivo
    Caihua Xu
    Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China
    PLoS ONE 8:e68837. 2013
    The Wilms' tumor suppressor gene (WT1) has been identified as an oncogene in many malignant diseases such as leukaemia, breast cancer, mesothelioma and lung cancer...
  11. pmc High affinity binding sites for the Wilms' tumour suppressor protein WT1
    T B Hamilton
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    Nucleic Acids Res 23:277-84. 1995
    The Wilms' tumour suppressor protein (WT1) is a putative transcriptional regulatory protein with four zinc fingers, the last three of which have extensive sequence homology to the early growth response-1 (EGR-1) protein...
  12. pmc Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways
    R T Sitaram
    Department of Medical Biosciences and Pathology, Umea University, Umea, Sweden
    Br J Cancer 103:1255-62. 2010
    Wilms' tumour 1 (WT1) gene was discovered as a tumour suppressor gene. Later findings have suggested that WT1 also can be oncogenic. This complexity is partly explained by the fact that WT1 has a number of target genes.
  13. doi Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety
    Toshiki Ochi
    Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime University Proteo Medicine Research Center, Ehime, Japan
    Blood 118:1495-503. 2011
    ..the clinical application of siTCR gene therapy for human leukemia, we examined in detail the efficacy and safety of WT1-siTCR-transduced T cells...
  14. doi Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma
    An Coosemans
    Laboratory of Experimental Gynecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 21:302-8. 2011
    Wilms tumor gene 1 (WT1) contributes to uterine sarcoma tumor biology. In this study, we aimed to clarify the prognostic value of WT1.
  15. doi WT1 overexpression at diagnosis may predict favorable outcome in patients with de novo non-M3 acute myeloid leukemia
    Maurizio Miglino
    Department of Hematology and Oncology, Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Leuk Lymphoma 52:1961-9. 2011
    ..prognostic significance of FLT3 (fms-like tyrosine kinase receptor-3) and NPM (nucleophosmin) gene mutations and WT1 (Wilms' tumor) and BAALC (brain and acute leukemia, cytoplasmic) gene expression in 100 consecutive patients with ..
  16. pmc WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia
    Gregory McCarty
    Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Biol Chem 286:43634-43. 2011
    b>WT1 is a zinc finger transcription factor expressed at high levels in many types of solid tumors, and high WT1 expression is an adverse prognostic factor. How WT1 contributes to tumor growth and influences prognosis remains unclear...
  17. ncbi High WT1 expression is associated with very poor survival of patients with osteogenic sarcoma metastasis
    Alok Srivastava
    Department of Orthopedics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Clin Cancer Res 12:4237-43. 2006
    ..The purpose of the investigation was to identify genes underlying survival outcome of patients with osteogenic sarcoma metastasis...
  18. doi Wilms' tumor 1 suppressor gene mediates antiestrogen resistance via down-regulation of estrogen receptor-alpha expression in breast cancer cells
    Youqi Han
    Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Mol Cancer Res 6:1347-55. 2008
    ..Wilms' tumor 1 suppressor gene (WT1) is a clinically useful marker that is associated with poor prognosis in breast cancer patients; its high level ..
  19. ncbi HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells
    Musaffe Tuna
    Department of Experimental Therapeutics, Unit 422, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA
    Oncogene 24:1648-52. 2005
    High levels of the Wilms' Tumor 1 (WT1) protein and mRNA had been associated with aggressive phenotypes of breast tumors. Here we report that the HER2/neu oncogene increases WT1 expression...
  20. doi Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer
    Seiji Hayashi
    Department of Internal Medicine, National Hospital Organization, Kinki chuo Chest Medical Center, Osaka, Japan
    Cancer Invest 30:165-71. 2012
    We elucidated the relationship between prognosis of non-small-cell lung cancer (NSCLC) and Wilms' tumor gene (WT1) mRNA expression in tumor tissue...
  21. doi Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
    Iris H I M Hollink
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 113:5951-60. 2009
    Wilms tumor 1 (WT1) mutations have recently been identified in approximately 10% of adult acute myeloid leukemia (AML) with normal cytogenetics (CN-AML) and are associated with poor outcome...
  22. ncbi Molecular profiling of CD34+ cells in idiopathic myelofibrosis identifies a set of disease-associated genes and reveals the clinical significance of Wilms' tumor gene 1 (WT1)
    Paola Guglielmelli
    Department of Hematology, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy
    Stem Cells 25:165-73. 2007
    ..According to class prediction analysis, a set of eight genes (CD9, GAS2, DLK1, CDH1, WT1, NFE2, HMGA2, and CXCR4) properly recognized IM from normal CD34(+) cells...
  23. doi Standardization of WT1 mRNA quantitation for minimal residual disease monitoring in childhood AML and implications of WT1 gene mutations: a European multicenter study
    A M Willasch
    Department of Pediatric Hematology, Oncology and Hemostaseology, Goethe University Frankfurt, Hospital for Children and Adolescents III, Frankfurt am Main, Germany
    Leukemia 23:1472-9. 2009
    ..Although hyperexpression of Wilms' tumor (WT1) gene transcript has been frequently proposed as an MRD marker in AML, wide comparability of the various methods ..
  24. doi WT 1 expression in nevi and melanomas: a marker of melanocytic invasion into the dermis
    M C Garrido-Ruiz
    Dpto de Anatomía Patológica, Hospital Universitario12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    J Cutan Pathol 37:542-8. 2010
    b>WT1, first recognized as a tumor suppressor gene involved in the development of Wilms' tumor, may have apparently contradictory findings and functions...
  25. ncbi Wilms' tumor gene 1 expression analysis by real-time quantitative polymerase chain reaction for monitoring of minimal residual disease in acute leukemia
    Alicja Nowakowska-Kopera
    Department of Hematology, Collegium Medicum, Jagiellonian University, Cracow, Poland
    Leuk Lymphoma 50:1326-32. 2009
    Wilms' tumor gene 1 (WT1) gene expression was analyzed in 32 patient with acute myeloid leukemia (AML) and 18 with acute lymphoblastic leukemia (ALL) to investigate whether it could serve as a MRD marker...
  26. doi WT1 expression as an independent marker of poor prognosis in colorectal cancers
    Tanan Bejrananda
    Department of Surgery, Prince of Songkla University, Hat Yai, Thailand
    Cancer Biomark 8:35-42. 2010
    b>WT1 has been proven to be a prognostic marker and molecular target in various human cancers. In this study, we aimed to investigate the prognostic role of WT1 in colorectal cancers (CRCs)...
  27. doi Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1)
    Eneda Toska
    Department of Biological Sciences, University at Buffalo, Buffalo, NY 14260, U S A
    Biochem J 461:15-32. 2014
    The WT1 (Wilms' tumour 1) gene encodes a zinc finger transcription factor and RNA-binding protein that direct the development of several organs and tissues...
  28. pmc Prognostic significance of WT1 expression in soft tissue sarcoma
    Ahrong Kim
    Department of Pathology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam do 626 870, Republic of Korea
    World J Surg Oncol 12:214. 2014
    Soft tissue sarcomas (STS) are rare. We evaluated the WT1 protein expression level in various types of STS and elucidated the value of WT1 as a prognostic factor and a possible therapeutic target.
  29. ncbi Downregulation of Wilms' tumor 1 protein inhibits breast cancer proliferation
    Pablo Zapata-Benavides
    Department of Bioimmunotherapy, Section of Immunobiology and Drug Carriers, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 422, Houston, TX 77030, USA
    Biochem Biophys Res Commun 295:784-90. 2002
    High levels of Wilms' Tumor 1 (WT1) mRNA have been correlated with poor prognosis in breast cancer patients. However, the function of WT1 protein in breast cancer is not known...
  30. doi Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia
    Anna Candoni
    Division of Hematology and Bone Marrow Transplantation, Department of Medical and Morphologic Research, University of Udine, Udine, Italy
    Eur J Haematol 82:61-8. 2009
    b>WT1 overexpression is described in several oncological diseases including acute myeloid leukemia (AML)...
  31. pmc Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1
    A L Gashler
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637 1963
    Proc Natl Acad Sci U S A 89:10984-8. 1992
    ..A gene implicated in the genesis of this tumor, the Wilms tumor suppressor gene (WT1), encodes a zinc-finger DNA-binding protein (WT1) that functions as a transcriptional repressor...
  32. ncbi Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome
    J Pelletier
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 02139
    Cell 67:437-47. 1991
    ..To investigate its possible role, we have analyzed the coding exons of the Wilms' tumor suppressor gene (WT1) for germline mutations...
  33. ncbi The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma
    S Park
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    Nat Genet 4:415-20. 1993
    The tumour suppressor gene WT1 encodes a transcription factor expressed in tissues of the genito-urinary system. Inactivation of this gene is associated with the development of Wilms tumour a pediatric kidney cancer...
  34. ncbi A non-AUG translational initiation event generates novel WT1 isoforms
    W Bruening
    Department of Biochemistry, McGill University, 3655 Drummond St, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 271:8646-54. 1996
    The Wilms' tumor (WT) suppressor gene, WT1, is mutated in a small set of WTs and is essential for proper development of the urogenital system...
  35. ncbi Paternal expression of WT1 in human fibroblasts and lymphocytes
    K Mitsuya
    Department of Molecular and Cell Genetics, School of Life Sciences, Faculty of Medicine, Tottori University, Nishimachi 86, Yonago, Tottori 683, Japan
    Hum Mol Genet 6:2243-6. 1997
    The Wilms' tumor suppressor gene ( WT1 ) was previously identified as being imprinted, with frequent maternal expression in human placentae and fetal brains...
  36. ncbi Upregulation of Wilms' tumour gene 1 (WT1) in uterine sarcomas
    A Coosemans
    Leuven Cancer Institute LKI, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Cancer 43:1630-7. 2007
    Overexpression of Wilms' tumour gene (WT1) has been proven in several tumours. Previous research of our group on the cell cycle of uterine leiomyosarcoma (LMS) and carcinosarcoma (CS) suggested a possible role for WT1...
  37. ncbi Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors
    Naoya Tatsumi
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Int J Oncol 32:701-11. 2008
    Wilms' tumor gene WT1 is overexpressed in leukemia and various types of solid tumors and plays an important role in leukemogenesis and tumorigenesis...
  38. pmc An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1
    Marianne K H Kim
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:11154-9. 2009
    b>WT1, a critical regulator of kidney development, is a tumor suppressor for nephroblastoma but in some contexts functions as an oncogene...
  39. doi Wilms' tumor protein and FLT3-internal tandem duplication expression in patients with de novo acute myeloid leukemia
    B V Spassov
    Department of Clinical Haematology, Specialized Hospital for Active Therapy of Hematological Diseases, Sofia, Bulgaria
    Hematology 16:37-42. 2011
    Bone marrow samples of 30 patients with de novo adult acute myeloid leukemia (AML) were analyzed for Wt1 and FLT3-internal tandem duplication (FLT3-ITD) expression measured by western blot and reverse transcription-polymerase chain ..
  40. doi Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β
    Reinhard Depping
    Institut fur Physiologie, Zentrum für Medizinische Struktur und Zellbiologie, Universitat zu Lubeck, Lubeck, Germany
    Cell Physiol Biochem 29:223-32. 2012
    Wilms' tumour protein, Wt1, is a zinc finger molecule, which is required for normal embryonic development. Mutations of the WT1 gene can give rise to childhood cancer of the kidneys...
  41. doi Wilms' tumor gene 1: a possible new proangiogenic factor in Hodgkin lymphoma
    Zahava Vadasz
    The Hematology Division, Bnai Zion Medical Center, Haifa, Israel
    Appl Immunohistochem Mol Morphol 21:177-80. 2013
    Wilms' tumor gene 1 (WT1) was recently found to play a role in solid and hematologic malignancies and serves as a marker of prognosis and minimal residual disease in acute leukemia. WT1 was also found to be involved in tumor angiogenesis...
  42. doi WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio
    Thomas J Cunningham
    Newcastle University Institute of Genetic Medicine, International Centre for Life, Newcastle, United Kingdom
    Blood 122:188-92. 2013
    Mutations in the Wilms tumor suppressor 1 (WT1) gene are as frequent in acute myeloid leukemia (AML) as in nephroblastma and predict poor prognosis. However, the role of WT1 in hematopoiesis remains unclear...
  43. pmc The Wilms' tumour suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A2 receptor gene in megakaryocytes
    AnneMarie M Gannon
    UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
    J Cell Mol Med 13:4571-86. 2009
    ..mobility shift assays and supershift assays demonstrated that each of the GC elements can bind Egr1 and WT1 in vitro, chromatin immunoprecipitations established that WT1 is the factor predominantly bound to each of the ..
  44. doi Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy
    Daniela Cilloni
    Dept of Clinical and Biological Sciences of the University of Turin, San Luigi Hospital, Gonzole 10, 10043 Orbassano, Turin, Italy
    Haematologica 93:921-4. 2008
    The Wilms' tumor gene WT1 is a reliable marker for minimal residual disease assessment in acute leukemia patients...
  45. doi Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group
    Verena Ingeborg Gaidzik
    Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
    Blood 113:4505-11. 2009
    To evaluate the incidence and clinical impact of WT1 gene mutations in younger adult patients with cytogenetically normal acute myeloid leukemia (CN-AML), sequencing of the complete coding region was performed in diagnostic samples from ..
  46. ncbi HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN
    Mohammad Husain
    Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    AIDS 19:1975-80. 2005
    ..To determine the specific role of Nef in the pathogenesis of HIV-associated nephropathy...
  47. ncbi Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells
    E Svensson
    Division of Hematology and Transfusion Medicine, Faculty of Medicine, Lund University, Lund, Sweden
    Leukemia 21:2485-94. 2007
    The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. Co-expression of WT1 and the fusion protein AML1-ETO in mice rapidly induces acute myeloid leukaemia (AML)...
  48. ncbi Wilms tumour gene 1 overexpression in bone marrow as a marker for minimal residual disease in acute myeloid leukaemia
    Mauri M Hämäläinen
    Department of Clinical Chemistry, University of Turku, Turku, Finland
    Eur J Haematol 80:201-7. 2008
    Wilms tumour gene 1 (WT1) is overexpressed in leucocytes of most acute myeloid leukaemia (AML) patients. However, the clinical relevance of WT1 gene expression as minimal residual disease (MRD) marker in AML has been questioned.
  49. doi Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology
    Liying Han
    Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan, USA
    Diagn Cytopathol 38:333-6. 2010
    ..staining of eight commercially available antibodies MUC1, MUC2, MUC5ac, Wilm's tumor susceptibility gene 1 (WT1), cytokeratin 7 (CK7), CK20, CA125, and CA19...
  50. doi The clinical relevance of Wilms Tumour 1 (WT1) gene mutations in acute leukaemia
    Carolyn Owen
    Division of Hematology and Hematological Malignancies, University of Calgary, 601A South Tower, Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta, T2N 2T9, Canada
    Hematol Oncol 28:13-9. 2010
    ..Mutations in the Wilms Tumour 1 (WT1) gene were first described more than a decade ago but their clinical significance has only recently been evaluated...
  51. pmc Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    Heiko Becker
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Blood 116:788-92. 2010
    We previously reported the adverse prognostic impact of Wilms tumor 1 gene (WT1) mutations in younger adult cytogenetically normal acute myeloid leukemia (CN-AML)...
  52. ncbi WT1 proteins: functions in growth and differentiation
    V Scharnhorst
    Department of Molecular and Cellular Biology and Center for Biomedical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, The, Leiden, Netherlands
    Gene 273:141-61. 2001
    The Wilms' tumor 1 gene (WT1) has been identified as a tumor suppressor gene involved in the etiology of Wilms' tumor. Approximately 10% of all Wilms' tumors carry mutations in the WT1 gene...
  53. ncbi WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    Jian Kan Guo
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hum Mol Genet 11:651-9. 2002
    ..provide genetic evidence that reduced levels of Wt1 are responsible for the pathogenesis of two distinct renal diseases and offer a molecular explanation for the increased occurrence of glomerulosclerosis in patients with WAGR syndrome.
  54. ncbi A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus
    Manakan B Srichai
    Departments of Medicine and Physiology and Biophysics, School of Medicine, Case Western Reserve University and Rammelkamp Center for Research and Education, MetroHealth System Campus, Cleveland, Ohio 44109 1998, USA
    J Biol Chem 279:14398-408. 2004
    Glomerular podocyte differentiation state is critical for filtration barrier function and is regulated by WT1, a zinc finger transcription factor...
  55. ncbi Sp1 is a critical regulator of the Wilms' tumor-1 gene
    H T Cohen
    Renal Division, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:2901-13. 1997
    We performed deletion analysis of WT1-reporter constructs containing up to 24 kilobases of 5'-flanking and first intron WT1 sequence in stably transfected cultured cells as an unbiased approach to identify cis elements critical for WT1 ..
  56. pmc Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology
    V Schumacher
    Institute of Human Genetics, University of Heidelberg, Germany
    Proc Natl Acad Sci U S A 94:3972-7. 1997
    The WT1 gene, located on chromosome 11p13, is mutated in a low number of Wilms tumors (WTs). Germ-line mutations in the WT1 gene are found in patients with bilateral WT and/or associated genital tract malformations (GU)...
  57. ncbi Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor development
    Brigitte Royer-Pokora
    Institute of Human Genetics and Anthropology, University Hospital, Heinrich Heine University, Duesseldorf, Germany
    Am J Med Genet A 127:249-57. 2004
    We report here 24 new Wilms tumor (WT) patients with germline WT1 alterations and a synopsis of our own previously described and literature cases in whom age of tumor-onset, gender, and laterality were known...
  58. ncbi Frequency and heritability of WT1 mutations in nonsyndromic Wilms' tumor patients: a UK Children's Cancer Study Group Study
    Suzanne E Little
    Paediatric Oncology Unit, The Royal Marsden NHS Trust, Downs Rd, Sutton, Surrey, SM2 5PT United Kingdom
    J Clin Oncol 22:4140-6. 2004
    Constitutional WT1 mutations in patients with Wilms' tumor (WT) have specifically been associated with genitourinary abnormalities, such as cryptorchidism and hypospadias...
  59. ncbi WT1 expression in angiogenic tumours of the skin
    J Timar
    Diagnostic Pathology, National Institute of Oncology, Budapest, Hungary
    Histopathology 47:67-73. 2005
    To determine the expression of WT1 in endothelial proliferations and tumours. Endothelial cells are derived from angioblasts which differentiate into bone marrow stem cells (BMSC)...
  60. pmc WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression
    Debra J Morrison
    Division of Hematology Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cancer Res 6:1225-31. 2008
    In its role as a tumor suppressor, WT1 transactivates several genes that are regulators of cell growth and differentiation pathways...
  61. ncbi The Wilms' tumor suppressor gene WT1 is negatively autoregulated
    H D Rupprecht
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215
    J Biol Chem 269:6198-206. 1994
    The Wilms' tumor suppressor gene WT1 encodes a zinc-finger DNA-binding protein that functions as a transcriptional repressor...
  62. ncbi The Wilms' tumor suppressor Wt1 is associated with the differentiation of retinoblastoma cells
    Nicole Wagner
    Johannes Müller Institut für Physiologie, Humboldt Universitat, Charite, 10117 Berlin, Germany
    Cell Growth Differ 13:297-305. 2002
    We have demonstrated recently that Wilms' tumor suppressor 1 (Wt1),in addition to its role in genitourinary formation,is required for the differentiation of ganglion cells in the developing retina...
  63. ncbi Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer
    Yusuke Oji
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Cancer Sci 94:606-11. 2003
    The expression levels of the Wilms' tumor gene WT1 were examined in 34 primary thyroid cancers (24 papillary, 5 follicular, 1 anaplastic, and 4 medullary carcinomas), 17 thyroid follicular adenomas, and 6 normal-appearing thyroid tissues ..
  64. ncbi Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells
    E A Burwell
    Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
    Oncogene 26:3423-30. 2007
    The role of WT1 (Wilm's tumor suppressor gene) in breast cancer is controversial, with evidence for both tumor-promoting and tumor-suppressing activities...
  65. doi The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo
    N Wagner
    INSERM U907, Nice, France
    Oncogene 27:3662-72. 2008
    ..We showed that the Wilms' tumour suppressor WT1 activates nestin during development. Here we tested whether WT1 might also be involved in tumour angiogenesis...
  66. ncbi Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1
    R W Johnstone
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:10880-7. 1998
    The Wilms tumor suppressor protein, WT1, is a transcription factor capable of activating or repressing transcription of various cellular genes...
  67. ncbi Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions
    V Scharnhorst
    Laboratory of Molecular Carcinogenesis and Centre for Biomedical Genetics, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Biol Chem 275:10202-11. 2000
    The WT1 gene, which is heterozygously mutated or deleted in congenital anomaly syndromes and homozygously mutated in about 15% of all Wilms tumors, encodes tissue-specific developmental regulators...
  68. ncbi A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1
    W Wang
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 276:16810-6. 2001
    The Wilms tumor gene WT1 encodes a zinc finger transcription factor that is required for normal kidney development...
  69. ncbi WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells
    Bilgin Gurates
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 87:4369-77. 2002
    ..inhibits SF-1-mediated induction of MIS and other steroidogenic genes, whereas Wilms' tumor suppressor gene (WT1) augments SF-1-mediated MIS expression...
  70. ncbi Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor
    Tae Ho Lee
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 277:44826-37. 2002
    The Wilms tumor suppressor gene, wt1, encodes a zinc finger transcription factor that has been implicated in the regulation of a number of genes...
  71. ncbi The complex life of WT1
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat Berlin, Germany
    J Cell Sci 116:1653-8. 2003
    The Wilms' tumour gene, WT1, encodes a zinc-finger transcription factor that is inactivated in a subset of Wilms' tumours...
  72. ncbi Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors
    Malini Udtha
    Department of Molecular Genetics Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 22:3821-6. 2003
    The Wilms' tumor suppressor gene, WT1, functions as a transcriptional regulator that represses or activates the expression of a variety of putative target genes...
  73. ncbi Transcriptional activity of testis-determining factor SRY is modulated by the Wilms' tumor 1 gene product, WT1
    Yumiko Matsuzawa-Watanabe
    Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Oncogene 22:7900-4. 2003
    The Wilms' tumor 1 (WT1) and sex-determining region of the Y chromosome (SRY) genes are essential for development of the mammalian gonads and mutations in these genes are associated with gonadal dysgenesis in humans...
  74. ncbi Transcriptional activation of c-myc proto-oncogene by WT1 protein
    Youqi Han
    Department of Cellular and Molecular Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Oncogene 23:6933-41. 2004
    The Wilms' tumor 1 gene (WT1) plays an essential role in urogenital development and malignancy...
  75. ncbi Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML
    K Summers
    Leukemia 21:550-1; author reply 552. 2007
  76. ncbi Coexpression of Wilms' tumor suppressor 1 (WT1) and androgen receptor (AR) in the genital tract of human male embryos and regulation of AR promoter activity by WT1
    Birgit Kohler
    Service d Hormonologie and Institut National de la Santé et de la Recherche Médicale U540, CHU Montpellier, Montpellier, France
    J Mol Endocrinol 38:547-54. 2007
    The Wilms' tumor suppressor 1 (WT1) is one of the key regulators of early male genital development. The androgen receptor (AR) is the major local factor responsible for the development of the male genitalia...
  77. ncbi The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis
    Suzie Ariyaratana
    Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Expert Rev Mol Med 9:1-17. 2007
    ..to its loss playing a pivotal role in the development of a childhood kidney malignancy, the Wilms tumour 1 gene (WT1) has emerged as an important factor in normal and malignant haematopoiesis...
  78. ncbi Wilms' tumor protein 1: an early target of progestin regulation in T-47D breast cancer cells that modulates proliferation and differentiation
    C E Caldon
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Oncogene 27:126-38. 2008
    ..progestin ORG 2058 (16alpha-ethoxy-21-hydroxy-19-norpregn-4-en-3,20-dione), all isoforms of Wilms' tumor protein 1 (Wt1) mRNA and protein were rapidly downregulated...
  79. ncbi The Wilms' tumor gene 1 (WT1) induces expression of the N-myc downstream regulated gene 2 (NDRG2)
    Emelie Svensson
    Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden
    DNA Cell Biol 26:589-97. 2007
    The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority of patients with acute and chronic myeloid leukemia...
  80. ncbi Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells
    Sharyn Thomas
    Department of Immunology and Molecular Pathology, University College London, Hampstead Campus, Royal Free Hospital, London, United Kingdom
    J Immunol 179:5803-10. 2007
    ..the functional activity of a human TCR specific for an HLA-A2-presented peptide derived from the Wilms tumor Ag 1 (WT1)...
  81. ncbi Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions
    Robert T Pu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Diagn Cytopathol 36:20-5. 2008
    ..A negative stain with MOC31 can exclude lung ADC. Mesothelin, on the other hand, is not useful in the differential diagnosis of ADC, SCC, and MM...
  82. doi Expression profile of orphan receptor tyrosine kinase (ROR1) and Wilms' tumor gene 1 (WT1) in different subsets of B-cell acute lymphoblastic leukemia
    Mahdi Shabani
    Department of Immunology, School of Public Health, Medical Sciences University of Tehran, Tehran, Iran
    Leuk Lymphoma 49:1360-7. 2008
    ..Wilms' tumor gene 1 (WT1) has long been known as a universal TAA expressed in a variety of solid and hematopoietic malignancies...
  83. doi Inhibition of epidermal growth factor receptor (EGFR) expression by human cytomegalovirus correlates with an increase in the expression and binding of Wilms' Tumour 1 protein to the EGFR promoter
    Insiya Jafferji
    Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, UK
    J Gen Virol 90:1569-74. 2009
    ..of EGFR expression and show that virus infection results in the profound upregulation of Wilms' Tumour 1 (WT1) protein, a transcription factor associated with the negative regulation of a number of growth factors and growth ..
  84. doi Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association
    Aline Renneville
    Department of Hematology, University of Lille Medical School, Lille, France
    Cancer 115:3719-27. 2009
    Wilms tumor 1 (WT1) is a transcription factor that is overexpressed in most acute myeloid leukemias (AMLs)...
  85. pmc Alternative splicing and genomic structure of the Wilms tumor gene WT1
    D A Haber
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 88:9618-22. 1991
    The chromosome 11p13 Wilms tumor susceptibility gene WT1 appears to play a crucial role in regulating the proliferation and differentiation of nephroblasts and gonadal tissue...
  86. pmc Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development
    A J Buckler
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 11:1707-12. 1991
    The human Wilms' tumor predisposition gene, WT1, is a Cys-His zinc finger polypeptide which appears to be a transcription factor controlling gene expression during embryonic kidney development...
  87. ncbi Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1
    S M Hewitt
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 55:5386-9. 1995
    The Wilms' tumor gene WT1 functions as a tumor suppressor gene, repressing transcription of several growth factors and growth factor receptors...
  88. pmc Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor
    W L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 92:1028-32. 1995
    ..recurrent translocation, t(11;22)(p13;q12), and rearrangement of the genes for Ewing sarcoma (EWS) and Wilms tumor (WT1)...
  89. ncbi Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues
    S Mundlos
    Department of Pediatrics, University of Mainz, Germany
    Development 119:1329-41. 1993
    The human Wilms' tumor gene WT1 encodes a putative transcription factor implicated in tumorigenesis and in specifying normal urogenital development...
  90. pmc WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes
    R C Davies
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genes Dev 12:3217-25. 1998
    b>WT1 is essential for normal kidney development, and genetic alterations are associated with Wilms' tumor, Denys Drash (DDS), and Frasier syndromes...
  91. ncbi The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin
    S B Lee
    Laboratory of Molecular Genetics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
    Cell 98:663-73. 1999
    b>WT1 encodes a zinc finger transcription factor implicated in kidney differentiation and tumorigenesis. In reporter assays, WT1 represses transcription from GC- and TC-rich promoters, but its physiological targets remain uncertain...
  92. ncbi Cyclin E is a target of WT1 transcriptional repression
    David M Loeb
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Biol Chem 277:19627-32. 2002
    b>WT1 was originally identified as a Wilms' tumor suppressor gene, but it may have oncogenic potential in leukemia and in some solid tumors...
  93. ncbi Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas
    Takafumi Ueda
    Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka
    Cancer Sci 94:271-6. 2003
    The expression levels of the Wilms' tumor gene WT1 were examined in 36 cases of various types of human bone and soft-tissue sarcomas using quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR)...
  94. ncbi Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours
    Anthony R Dallosso
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, UK
    Hum Mol Genet 13:405-15. 2004
    ..Here we report that a novel alternative WT1 transcript, AWT1, is co-expressed with WT1 in renal and haematopoietic cells...
  95. pmc BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1
    Brian Carpenter
    School of Biological Sciences, University of Manchester, G 186 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Cell Biol 24:537-49. 2004
    The Wilms' tumor suppressor protein WT1 is a transcriptional regulator that plays a key role in the development of the kidneys...
  96. ncbi Prognostic implications of Wilms' tumor gene (WT1) expression in patients with de novo acute myeloid leukemia
    Eva Barragan
    Molecular Biology Laboratory, Dept Medical Biopathology, Hematology Service of Hospital Universitario La Fe Hematology Services of Hospital General Universitario Alicante, Spain
    Haematologica 89:926-33. 2004
    The Wilms' tumor (WT1) gene is overexpressed in patients with most forms of acute leukemia. Several studies have reported the usefulness of quantitative assessment of WT1 expression as a molecular marker of minimal residual disease...
  97. pmc Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    Yoshihiro Oka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:13885-90. 2004
    The Wilms' tumor gene WT1 is overexpressed in leukemias and various types of solid tumors, and the WT1 protein was demonstrated to be an attractive target antigen for immunotherapy against these malignancies...
  98. ncbi Overexpression of the Wilms' tumor gene W T1 in primary astrocytic tumors
    Yusuke Oji
    Department of Bioinformatics, Osaka University Graduate School of Medicine, 1 7 Yamada oka, Suita, Osaka 565 0871, Japan
    Cancer Sci 95:822-7. 2004
    ..These results may indicate that the W T1 gene plays an important role in tumorigenesis of primary astrocytic tumors...
  99. ncbi WT1 activates a glomerular-specific enhancer identified from the human nephrin gene
    Gordon Guo
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Nephrol 15:2851-6. 2004
    ..The Wilms tumor suppressor gene (WT1) is a zinc-finger-containing transcription factor that is coexpressed with NPHS1 in differentiated podocytes; gel ..
  100. ncbi Upregulation of Wilms' tumor gene 1 (WT1) in desmoid tumors
    Saeid Amini Nik
    Center for Human Genetics, University of Leuven, Leuven, Belgium
    Int J Cancer 114:202-8. 2005
    ..It has been shown that the Wnt signaling pathway interacts with Wilms' tumor gene 1 (WT1) in normal kidney development and plays a role in the genesis of some Wilms' tumors...
  101. ncbi Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway
    K Ito
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Oncogene 25:4217-29. 2006
    The WT1 gene is overexpressed in human primary leukemia and a wide variety of solid cancers. The WT1 gene is alternatively spliced at two sites, yielding four isoforms: 17AA(+)KTS(+), 17AA(+)KTS(-), 17AA(-)KTS(+), and 17AA(-)KTS(-)...

Research Grants63

  1. Conditional Knockout of WT1 in Sertoli Cells In Vivo
    Michelle Barton; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): WT1 is a transcription factor originally discovered because of its association with genetically acquired childhood abnormalities, including Wilms' tumor...
  2. Targeting DNA Secondary Structures for Bcl-2 Gene Regulation
    Danzhou Yang; Fiscal Year: 2013
    ..This GC-rich region contains a binding site of the WT1 protein which has been shown to be a negative regulator of the bcl-2 gene expression...
  3. RNA Targets of the Wilm's Tumor Protein in the Kidney
    Russ Carstens; Fiscal Year: 2005
    Products of the Wilm's tumor gene (WT1) are required for both the development of the kidney as well as maintenance of normal glomerular structure and function...
  4. WILLIAM TSWENCHING PU; Fiscal Year: 2016
    ..Epicardial progenitors, marked by expression of the transcription factor Wt1 (Wilms Tumor Suppressor 1), were a major target of VEGF-A m*RNA activity...
  5. GLYCOLYTIC & PEROXISOMAL GENES ON CHROMOSOME 11 AND 12
    GAIL BRUNS; Fiscal Year: 1993
    ..a region of chromosome 11, distal 11p12-proximal 11p14, all or part of which is characteristically deleted in the WAGR syndrome (Wilms tumor, aniridia, genitourinary anomalies and mental retardation)...
  6. Functional Characterization of WTX in Renal Development
    MIGUEL NICOLAS RIVERA; Fiscal Year: 2011
    ..WT1 is essential for kidney development in mice and it is also responsible for genitourinary defects in the WAGR, Denys-Drash and Frasier syndromes. WT1, however, is inactivated in only 5-10% of sporadic Wilms'tumors...
  7. GENES, CHROMOSOMAL REGIONS AND DEVELOPMENTAL DISORDERS
    GAIL BRUNS; Fiscal Year: 2000
    ..The deletion region of the WAGR contiguous gene syndrome (Wilms tumor, aniridia, genitourinary anomalies and mental retardation ) is a model for ..
  8. Wendy M Leisenring; Fiscal Year: 2016
    ..Biological samples collected from patients on NWTS-5 will be used to test the hypothesis that mutations in the WT1 gene not only predispose to WT in childhood but also to ESRD in adolescence and adulthood...
  9. ERIC ALEJANDRO SWEET-CORDERO; Fiscal Year: 2016
    ..We have identified a novel role for Wilms tumor-1 (WT1) as a critical regulator of senescence and proliferation downstream of oncogenic KRAS...
  10. Analysis of Expression and LOH in Trout Nephroblastomas
    Gary Thorgaard; Fiscal Year: 2003
    ..Irregularities in the functioning of the Wilms' tumor gene (WT1), which is normally involved in kidney and gonadal development and sex differentiation, appear to play a ..
  11. Targets of Ewing Sarcoma-Wilms Tumor 1 Oncoprotein
    Daniel Haber; Fiscal Year: 2006
    ..domain (NTD) of the Ewing Sarcoma gene EWS to the three C-terminal zinc fingers of the Wilms tumor suppressor gene WT1, whose DNA binding domain is modulated by alternative splicing (plus/minus insertion of three amino acids, KTS)...
  12. WILMS TUMOR-1 GENE REGULATION IN KIDNEY DEVELOPMENT
    Vikas Sukhatme; Fiscal Year: 2001
    ..Because WT-1 has been documented to be essential for kidney development, the proposed studies will use the WT1 gene as an entry point to begin identifying the cis-acting regulatory elements and their associated transcription ..
  13. Targeted Suppression of the Transcription Factor Sox9 in the Testis by Tissue-Spe
    Manjeet Rao; Fiscal Year: 2007
    ..proof of principle for my newly developed in vivo RNAi approach that I used to knock down Wilms' tumor 1 gene (WT1) in a tissue-specific manner...
  14. TUMOR SUPPRESSOR GENE AND CHEMICAL CARCINOGENESIS
    Saraswati Sukumar; Fiscal Year: 2000
    DESCRIPTION: WT1 (Wilms tumor 1), a zinc finger-containing tumor suppressor protein plays a crucial role in the developing urogenital system and behaves as a transcriptional repressor of genes involved in growth...
  15. ROLE OF IGFS IN WILMS TUMOR DEVELOPMENT
    JAMES PERDUE; Fiscal Year: 1991
    ..It has been suggested (3) that macro-or micro- alterations of a repressor gene ie, WAGR, in chromosome brand 11p13 could stimulate IGF-II synthesis and it, in turn would stimulate the replication of the ..
  16. STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF WT1
    J Joung; Fiscal Year: 2004
    DESCRIPTION (adapted from the application) The WT1 gene plays an essential role in normal kidney and gonadal development and has also been implicated in the pathogenesis of the embryonic kidney malignancy Wilms' tumor...
  17. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004
    ..Although a gene for Wilms tumor (WT1) has been cloned, less than 10% of cases could be explained by mutations and/or alterations of this gene...
  18. Genetic Mechanisms of Mammalian Sex Determination
    KENNETH ALBRECHT; Fiscal Year: 2007
    ..In humans, heterozygous mutations in WT1 (Wilms' tumor-1) or SF1 (Steroidogenic factor-1) are associated with XY sex reversal...
  19. MABS TO TUMOR SUPPRESSOR GENE DCC-ENCODED PROTEIN
    CHUNMING HUANG; Fiscal Year: 1992
    ..The tumor suppressor genes Rb,p53,WT1,NF-1,DCC and MCC have been cloned...
  20. REGULATION OF CELL GROWTH BY THE WILMS TUMOR GENE
    Zhao Yi Wang; Fiscal Year: 2002
    DESCRIPTION: (Adapted from investigator's abstract) The Wilms' tumor suppressor gene, wt1, encodes a zinc finger transcription factor, WT1...
  21. The WT1 Interacting Protein: a choreographer of morphology and transcription
    Jane Kim; Fiscal Year: 2012
    ..Activity of the transcription factor, WT-1, is required for normal podocyte structure and is repressed by the WT1 Interacting Protein (WTIP)...
  22. FUNCTIONAL PROPERTIES OF THE WILMS TUMOR GENE WT1
    Daniel Haber; Fiscal Year: 2002
    DESCRIPTION: (adapted from the investigator's abstract) WT1 is a developmentally regulated kidney zinc finger transcription factor which is inactivated in the germline of children predisposed to Wilm's tumor...
  23. Mechanisms in Wilms Tumorigenesis
    Bryan Williams; Fiscal Year: 2003
    ..the urogenitary system and a shared genetic origin has become evident from the cloning and characterization of the WT1 locus by ourselves and others...
  24. A Mouse Model for Glomerulosclerosis and Early Onset Renal Failure
    Vicki Huff; Fiscal Year: 2010
    ..To elucidate these mechanisms, we generated a novel mouse strain carrying a missense mutation (R394W) in the Wt1 gene which encodes a zinc finger transcription factor and is expressed in the glomerular podocyte...
  25. Genes disrupted be a t(5;6) in a Wilms Tumor Patients
    Michael Higgins; Fiscal Year: 2004
    ..The WT1 gene was identified more than 10 years ago and, despite the efforts of several laboratories, remains the only tumor ..
  26. A NEW CANDIDATE VACCINE FOR LEUKEMIA AND CANCER
    Alexander Gaiger; Fiscal Year: 1999
    Wilms' tumor (WT1) gene participates in leukemogenesis, is overexpressed in most human leukemias and is detectable in many other human cancers...
  27. Array Based CGH for Genome-Wide Analysis of Wilms' Tumor
    Norma Nowak; Fiscal Year: 2004
    ..The WT1 gene was identified and positionally cloned in 1991, but we have shown that this gene is only involved in a very ..
  28. REGULATION OF THE IGF-I RECEPTOR GENE BY WT1
    Charles Roberts; Fiscal Year: 1999
    ..The product of WT1, the Wilms tumor suppressor gene, is a zinc-finger transcription factor that generally represses its target genes...
  29. GENETIC ANALYSIS OF MALIGNANCY
    Eric Stanbridge; Fiscal Year: 1999
    ..The functional roles of several candidate Wilms' tumor TS genes, namely WT1, QM and H19, will be examined. in addition, we continue to collaborate with Dr...
  30. BIOLOGICAL PROGNOSTIC FACTORS IN WILMS TUMOR
    Daniel Green; Fiscal Year: 1999
    ..of heterozygosity at 22q and 7p; 2) Mutation at the GPC3 locus; 3) Telomerase activity in tumor tissue; 4) Aberrant WT1 mRNA splicing; and 5) Loss of heterozygosity at 5q...
  31. MOLECULAR INVESTIGATION OF FAMILIAL WILMS TUMOR
    Vicki Huff; Fiscal Year: 2003
    ..One Wilms tumor gene is known: the transcription factor WT1 on chromosome 11p...
  32. The p270 SWI/SNF subunit as a potential Wilms' tumor susceptibility gene
    Elizabeth Moran; Fiscal Year: 2009
    ..is that deficiency of p270/ARID1A is functionally similar to loss of Wilms'tumor susceptibility gene 1 (WT1), and that ARID1A itself is a susceptibility gene for Wilms'tumor...
  33. Ming Jer Tsai; Fiscal Year: 2014
    ..Preliminary results suggest that COUP-TFII regulates the expression of Angiopoietin 1, WT1, PKD1, TGF and many inflammatory genes, raising the possibility that COUP-TFII functions to protect the kidney from ..
  34. Molecular genetics of epithelium formation in C. elegans
    Stephen E Von Stetina; Fiscal Year: 2010
    ..For example, Wilms'Tumor, a childhood cancer, can be caused by a mutation in the Wilms'Tumor 1 (WT1) gene. WT1 mutant mice fail to form a complete kidney due to a defect in epithelium formation...
  35. Stefan Roberts; Fiscal Year: 2015
    ..How these disparate activities of WT1 are regulated is not clear, but have important implications in determining its role in multiple cancers...
  36. ALAN FINE FINE; Fiscal Year: 2016
    ..are to address this fundamental issue and to assess the key role of the Wilm's tumor 1 transcription factor (WT1) in these events...
  37. Characterization of a novel protein required for glomerular podocyte function
    LORI L O'BRIEN; Fiscal Year: 2012
    ..It is a downstream target of Wilms'tumor suppressor-1 (WT1) and binds capnsi, the small subunit of the cysteine protease calpain...
  38. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..Aim 1, global methylation studies, comparing JDM with controls will identify areas of hypomethylation, such as the WT1 and HOX genes, and test their relation to intensity levels of miRNA expression...
  39. Role of the cdx homeobox genes in the regulation of wt1 and nephron development
    Alan J Davidson; Fiscal Year: 2010
    ..This work advances our understanding of how kidneys arise in the embryo and may be lead to new therapeutic targets to treat or prevent chronic renal failure. ..
  40. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..genes in the gubernaculum that are known to be involved in gubernacular development, such as Hoxa10, Hoxa11, Wt1, Dll1 and Desrt, were not altered in mutant mice, while Lgr8, Notch1 and Numb mRNA levels were drastically deceased ..
  41. ANTIGEN SPECIFIC T CELL TOLERANCE BY ANTI CD3 ANTIBODIES
    Claudio Anasetti; Fiscal Year: 2012
    ..to third party alloantigens, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), and tumor- associated antigen WT1. PUBLIC HEALTH RELEVANCE: The development of effective regimens for the prevention of GVHD will improve patient ..
  42. EPITHELIAL OVARIAN CANCER PROGRAM PROJECT
    David Spriggs; Fiscal Year: 2009
    ..of tumor antigen specific cytotoxic T cells for adoptive therapy, employing HLA restricted epitopes from WT1 and MUC16...
  43. AUDE CHAPUIS; Fiscal Year: 2016
    ..CD8+ T-cell clones specific for WT1, a protein that is over-expressed in leukemic cells with the highest levels expressed in leukemic stem cells (LSC), ..
  44. PATHOGENESIS OF HAEMOPHILUS DUCREYI INFECTIONS
    Stanley M Spinola; Fiscal Year: 2013
    ..by applicant): Haemophilus ducreyi is a strict human pathogen that causes chancroid, a genital ulcer disease (GUD) that facilitates the transmission of the human immunodeficiency virus (HIV-1). To study the biology of H...
  45. SUPRIYA DINESH MEHTA; Fiscal Year: 2016
    ..MMC reduced genital ulcer disease (GUD) by 37-52%, and reduced GUD in female sex partners of circumcised men by 32%...
  46. Regulation of coronary vascular development by differential tissue hypoxia
    Michiko Watanabe; Fiscal Year: 2010
    ..specific aim will be to determine how HIF-1a regulates the activity of the Wilms'tumor suppressor gene product Wt1 in epicardial cells using in vitro systems. Genes directly regulated by HIF-1a and/or Wt1 will be identified...
  47. Hsal 2, A Novel Homeobox Gene in Hematopoiesis
    Li Chai; Fiscal Year: 2007
    ..to characterize the transcriptional regulation of Hsal2 with a focus on identification of the binding sites of WT1 and RAR-m The antagonistic effect between WT1 and RAR-_t on Hsal2 expression will be further explored by ..
  48. Daniel Harris; Fiscal Year: 2016
    ..Currently, we have isolated high-affinity TCRs against the cancer antigens Mart1 and WT1. Developing a high-affinity receptor against survivin will add to repertoire to receptors tested in other aims...
  49. RICHARD JOHN O'REILLY; Fiscal Year: 2016
    ..Project 5 tests new monoclonal antibodies specific for WT1 peptide/HLA complexes, long-lived EBV T-cells transduced to express TCRs or chimeric antigen receptors specific for ..
  50. Guillermina Lozano; Fiscal Year: 2014
    ..The interests of the faculty include the study of tumor suppressors (p53, PTEN, WT1, Brca1), genetic modifiers of the cancer phenotype, inherited cancer syndromes, the DNA damage response, DNA ..
  51. Transcriptional Control of Mammalian Sexual Development
    Sergei G Tevosian; Fiscal Year: 2013
    ..examine sexual development in a) Dkk1 null embryos and b) compound mutant Fog2-/-Dkk1-/-, GATA4ki/ki/Dkk1-/- and Wt1-Sox9/Dkk-/- embryos;and using the tetO-Dkk1 mouse strain we will over-express Dkk1 specifically in embryonic gonads ..
  52. Philip D Greenberg; Fiscal Year: 2016
    ..b>WT1 and mesothelin (MSN) are pro-oncogenic proteins over-expressed by many human tumors with limited expression in ..
  53. Circumcision: HIV/STIs and behaviors in a RCT and post-RCT surveillance;Rakai
    Ronald H Gray; Fiscal Year: 2011
    ..52, Cl 0.31-0.86, p = 0.012) and reduced GUD (RR=0.44, Cl 0.33-0.58, p<0.001) in circumcised men...
  54. Takashi Mikawa; Fiscal Year: 2016
    ..Importantly, ectopic expression of Pitx2 in bona fide PE cells can suppress a PE marker gene Wt1. At the right side, the PE undergoes massive outgrowth that precisely targets the inner curvature of the ..
  55. RASHEED ADEBAYO GBADEGESIN; Fiscal Year: 2016
    ..In preliminary studies, we have used this combination to identify a novel variant in the WT1 (Wilms'Tumor-1) gene in one FSGS family, and we have evidence suggesting it is the causal mutation...
  56. 2ND INTERNAT'L SYMPOSIUM OF VERTEBRATE SEX DETERMINATION
    Valentine Lance; Fiscal Year: 2000
    ..Homologues of a number of these genes (SF-1, SOX9, MIH, DAX1, WT1) have since been shown to be expressed in the differentiating gonads of fish, amphibians, reptiles and birds...
  57. MUTANT LINES OF ZEBRAFISH HIGHLY SENSITIVE TO NEOPLASIA
    Jan Spitsbergen; Fiscal Year: 2005
    ..cleavage enzyme CELI to detect point mutations in zebrafish orthologs of the human tumor suppressor genes P53, RB1, WT1, PTEN, or NF1...
  58. HIV DYNAMICS AND PREVENTION, RAKAI DISTRICT UGANDA
    Maria Wawer; Fiscal Year: 1992
    ..Current or previous symptoms of genital ulcer disease (GUD) and STD, and number of reported sexual partners were associated with serostatus...
  59. Mechanisms of Glomerular Scarring
    John Sedor; Fiscal Year: 2006
    ..b>WT1, a zinc finger transcription factor, critical for appropriate podocyte differentiation, expressed in mature ..
  60. Protein Interactions of the Germ Cell Kinase Haspin
    JONATHAN HIGGINS; Fiscal Year: 2004
    ..Par4 (prostate apoptosis response protein-4, also known as PRKC apoptosis WT1 regulator, PAWR) sensitizes cells to apoptosis, is a regulator of WT1 and has functional interactions with the ..
  61. Molecular Targeting of Developmental Cancers in Children
    RICHARD O REILLY; Fiscal Year: 2009
    ..Based on these studies, a phase I trial evaluating T cells specific for WT1 peptides in the treatment of WT1 malignancies of childhood will be conducted...
  62. Targeted Treatment of Leukemia with Specific CTL Clones
    William Ho; Fiscal Year: 2005
    ..Two candidate target antigens, WT1 and Proteinase 3 (PR3 or Myeloblastin), are selectively over expressed in many types of leukemias...
  63. REGULATION OF BCL2 BY RAS AND TUMOR SUPPRESSORS
    ALBERT BALDWIN JR; Fiscal Year: 2001
    ..Another tumor suppressor, WT1, has been demonstrated to modulate the bcl-2 promoter and to inhibit p53-mediated apoptosis...