WRAP53

Summary

Gene Symbol: WRAP53
Description: WD repeat containing antisense to TP53
Alias: DKCB3, TCAB1, WDR79, telomerase Cajal body protein 1, WD repeat-containing protein 79, WD repeat-containing protein WRAP53, WD40 protein Wrap53, WD40 repeat-containing protein antisense to TP53, WD40 repeat-containing protein encoding RNA antisense to p53
Species: human

Top Publications

  1. doi The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer
    Marianne Farnebo
    Dept of Oncology Pathology, Cancer Center Karolinska CCK, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 396:85-9. 2010
  2. pmc Telomerase recruitment requires both TCAB1 and Cajal bodies independently
    J Lewis Stern
    Children s Medical Research Institute and Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    Mol Cell Biol 32:2384-95. 2012
  3. pmc Overexpression of WRAP53 is associated with development and progression of esophageal squamous cell carcinoma
    Xuguang Rao
    Department of Thoracic and Cardiovascular Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China Department of Thoracic Surgery, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
    PLoS ONE 9:e91670. 2014
  4. pmc WRAP53 promotes cancer cell survival and is a potential target for cancer therapy
    S Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cell Death Dis 2:e114. 2011
  5. pmc Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
    Franklin Zhong
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 25:11-6. 2011
  6. pmc WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    PLoS Biol 8:e1000521. 2010
  7. ncbi Wrap53, a novel regulator of p53
    Marianne Farnebo
    Department of Oncology Pathology, Cancer Centrum Karolinska CCK, Karolinska Institutet, Stockholm SE 17176, Sweden
    Cell Cycle 8:2343-6. 2009
  8. ncbi TCAB1: driving telomerase to Cajal bodies
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Cell Cycle 8:1329-31. 2009
  9. doi Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Mol Cell 33:462-71. 2009
  10. pmc A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Science 323:644-8. 2009

Research Grants

  1. Steven E Artandi; Fiscal Year: 2014
  2. Steven E Artandi; Fiscal Year: 2015

Scientific Experts

  • Hui Qiu
  • Li Ying Xiao
  • Inderjeet Dokal
  • Deniz Aslan
  • Qing Lan
  • Montserrat Garcia-Closas
  • Santos Alonso
  • Marianne Farnebo
  • Steven E Artandi
  • Sofia Henriksson
  • Aaron R Poole
  • Jacob M Vogan
  • Christos Coucoravas
  • Andrew S Venteicher
  • Ricardo Saldaña-Meyer
  • Salah Mahmoudi
  • Michael D Hebert
  • Isioma I Enwerem
  • Hanif Rassoolzadeh
  • Kathleen Collins
  • Nasser Pouladi
  • Hong Zhang
  • Sharon A Savage
  • Blanche P Alter
  • Neelam Giri
  • Jorge Mata-Garrido
  • Ashish Goyal
  • H Y Cao
  • Yang Sun
  • Marwa M Kamel
  • Stina Garvin
  • Mo jin Wang
  • Laxmi Silwal-Pandit
  • Mengfan Tang
  • E Hedstrom
  • Aida Sedaie Bonab
  • Ping Yuan
  • Chong Kui Sun
  • Aline Marnef
  • Ji Hoon Lee
  • Xuguang Rao
  • Adam Freund
  • Sung Geun Cho
  • Xiao Feng Sun
  • Reyhaneh Ravanbakhsh Gavgani
  • Gunnar Adell
  • Parvin Azarfam
  • Caihong Xing
  • Thomas R Cech
  • Arthur J Zaug
  • Tamas Kiss
  • Krzysztof Medrek
  • Sandra Ortiz-Cuaran
  • Felix Recillas-Targa
  • Franklin L Zhong
  • Beata E Jady
  • J Lewis Stern
  • Shahinaz M Gadalla
  • Timothy D Veenstra
  • Zhaojing Meng
  • Luis F Z Batista
  • Amanda Polson
  • Jian Min Yuan
  • Alison B Singer
  • M Bug
  • Franklin Zhong
  • S Mahmoudi
  • Emily D Egan
  • Klas G Wiman
  • Kazimierz T Tycowski
  • Jens Laitinen
  • Kuangpei Wu
  • Amr S Saad
  • Olga Tapia
  • Soniya Dhanjal
  • Marwa Matboli
  • Cai Yang
  • Maria T Berciano
  • Matthias Groß
  • Xiaoxiao Hu
  • Iman F Montasser
  • Minlan Duan
  • Chao Yang
  • Maha Sallam
  • Marcel Klingenberg
  • Jing Liu
  • Ksenia Myacheva
  • Joshua Z Johnson
  • Jianglin Li
  • Xin Song

Detail Information

Publications60

  1. doi The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer
    Marianne Farnebo
    Dept of Oncology Pathology, Cancer Center Karolinska CCK, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 396:85-9. 2010
    ..A p53 antisense gene, Wrap53, enhances p53 mRNA levels via the 5'UTR...
  2. pmc Telomerase recruitment requires both TCAB1 and Cajal bodies independently
    J Lewis Stern
    Children s Medical Research Institute and Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    Mol Cell Biol 32:2384-95. 2012
    ..In human cells, recruitment depends on the Cajal body RNA chaperone TCAB1 binding to the RNA subunit of telomerase (hTR) and is also thought to rely on an N-terminal domain of the ..
  3. pmc Overexpression of WRAP53 is associated with development and progression of esophageal squamous cell carcinoma
    Xuguang Rao
    Department of Thoracic and Cardiovascular Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China Department of Thoracic Surgery, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
    PLoS ONE 9:e91670. 2014
    ..The natural antisense transcript (NAT) WRAP53 regulates p53 expression and WRAP53 protein is a component of telomerase...
  4. pmc WRAP53 promotes cancer cell survival and is a potential target for cancer therapy
    S Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cell Death Dis 2:e114. 2011
    We previously identified WRAP53 as an antisense transcript that regulates the p53 tumor suppressor...
  5. pmc Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
    Franklin Zhong
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 25:11-6. 2011
    ..We identify DC patients with missense mutations in TCAB1, a telomerase holoenzyme protein that facilitates trafficking of telomerase to Cajal bodies...
  6. pmc WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    PLoS Biol 8:e1000521. 2010
    The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies...
  7. ncbi Wrap53, a novel regulator of p53
    Marianne Farnebo
    Department of Oncology Pathology, Cancer Centrum Karolinska CCK, Karolinska Institutet, Stockholm SE 17176, Sweden
    Cell Cycle 8:2343-6. 2009
    ..b>Wrap53 is a natural antisense transcript of p53 that regulates endogenous p53 mRNA levels and is furthermore required for ..
  8. ncbi TCAB1: driving telomerase to Cajal bodies
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Cell Cycle 8:1329-31. 2009
    ..A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and function in vivo...
  9. doi Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Mol Cell 33:462-71. 2009
    ..We have identified a natural antisense transcript of p53, designated Wrap53, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated ..
  10. pmc A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Science 323:644-8. 2009
    ..Here, we identify a holoenzyme subunit, TCAB1 (telomerase Cajal body protein 1), that is notably enriched in Cajal bodies, nuclear sites of RNP processing that are important for ..
  11. ncbi Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Int J Cancer 121:2532-8. 2007
    ..We investigated the association of common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, with risk for breast cancer...
  12. pmc Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance
    Mengfan Tang
    Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China
    J Cell Sci 128:331-41. 2015
    ..These findings collectively support a DAXX-centric pathway for telomere maintenance, where DAXX interaction with the telomerase regulates telomerase assembly in Cajal bodies and telomerase targeting to telomeres. ..
  13. pmc Cajal body proteins differentially affect the processing of box C/D scaRNPs
    Isioma I Enwerem
    Department of Biochemistry, The University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, United States of America
    PLoS ONE 10:e0122348. 2015
    ..Here, we explore the processing of box C/D scaRNA 2 and 9 by coilin. We also broaden our investigation to include WRAP53 and SMN, which accumulate in CBs, play a role in RNP biogenesis and associate with coilin...
  14. ncbi Regulatory effects of WRAP53 on radiosensitivity of laryngeal squamous cell carcinoma cells
    Hui Qiu
    Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Cancer Clinical Study Center of Hubei Provinces Key Laboratory of Tumor Biological Behavior of Hubei Province, Wuhan, China E mail
    Asian Pac J Cancer Prev 16:2975-9. 2015
    Telomere length is closely associated with cellular radiosensitivity and WRAP53 is required for telomere addition by telomerase...
  15. pmc The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair
    Sofia Henriksson
    Department of Oncology Pathology, Cancer Centrum Karolinska CCK, Karolinska Institutet, Stockholm 171 76, Sweden
    Genes Dev 28:2726-38. 2014
    The WD40 domain-containing protein WRAP53β (WD40 encoding RNA antisense to p53; also referred to as WDR79/TCAB1) controls trafficking of splicing factors and the telomerase enzyme to Cajal bodies, and its functional loss has been linked ..
  16. pmc Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1
    Adam Freund
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 159:1389-403. 2014
    ..We find that TRiC is required for folding the telomerase cofactor TCAB1, which controls trafficking of telomerase and small Cajal body RNAs (scaRNAs)...
  17. doi Nuclear expression of WRAP53β is associated with a positive response to radiotherapy and improved overall survival in patients with head and neck squamous cell carcinoma
    Stina Garvin
    Department of Clinical Pathology and Clinical Genetics, and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden Division of Oto Rhino Laryngology and Head and Neck Surgery, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Oral Oncol 51:24-30. 2015
    ..Inherited mutation in WRAP53β (WD40 encoding RNA Antisense to p53), a protein involved in intracellular trafficking, dramatically increases ..
  18. doi Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase
    Ji Hoon Lee
    Department of Integrated OMICs for Biomedical Science, Graduate School of Yonsei University, 134 Shinchon dong, Seoul, 120 749, Korea
    Histochem Cell Biol 141:137-52. 2014
    ..Upon association with TCAB1 in S phase, the telomerase RNP is transported from nucleoli to Cajal bodies, suggesting that TCAB1 acts as an S-..
  19. doi Gene expression change in human dental pulp cells exposed to a low-level toxic concentration of triethylene glycol dimethacrylate: an RNA-seq analysis
    Sung Geun Cho
    Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea
    Basic Clin Pharmacol Toxicol 115:282-90. 2014
    ..HMOX1, OSGIN1, SMN2, SRXN1 AKR1C1, SPP1 and TOMM40L were highly up-regulated genes, and WRAP53 and CCL2 were highly down-regulated genes over time...
  20. doi Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population
    Aida Sedaie Bonab
    Department of Biology, Faculty of Natural Sciences, Tabriz University, Tabriz, Iran
    Med Oncol 31:168. 2014
    The WRAP53 (WD40-encoding RNA antisense to p53) gene encodes an antisense RNA, essential for p53 stabilization and induction upon DNA damage...
  21. pmc The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer
    Laxmi Silwal-Pandit
    Department of Cancer Genetics, Institute for Cancer Research, Division of Cancer Medicine, Surgery and Transplantation, Radiumhospitalet Oslo University Hospital, 0424 Oslo, Norway K G Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway
    PLoS ONE 10:e0139965. 2015
    b>WRAP53 protein controls intracellular trafficking of DNA repair proteins, the telomerase enzyme, and splicing factors. Functional loss of the protein has been linked to carcinogenesis, premature aging and neurodegeneration...
  22. pmc CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53
    Ricardo Saldaña-Meyer
    Instituto de Fisiologia Celular, Departamento de Genetica Molecular, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico
    Genes Dev 28:723-34. 2014
    ..Depletion of cellular CTCF led to a decrease in not only levels of p53 mRNA, as expected, but also those of Wrap53 RNA, an antisense transcript originated from the p53 locus...
  23. pmc Targeting vertebrate intron-encoded box C/D 2'-O-methylation guide RNAs into the Cajal body
    Aline Marnef
    Laboratoire de Biologie Moleculaire Eucaryote du CNRS, UMR5099, IFR109 CNRS, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Nucleic Acids Res 42:6616-29. 2014
    ..The WD-repeat protein 79 (WDR79) has been proposed to interact with both classes of modification scaRNPs and target them into the CB...
  24. pmc TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas
    Chong Kui Sun
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China
    Mol Cancer 13:180. 2014
    b>WRAP53, including α, β and γ isoforms, plays an important role not only in the stability of p53 mRNA, but also in the assembly and trafficking of the telomerase holoenzyme...
  25. pmc Telomerase Cajal body protein 1 depletion inhibits telomerase trafficking to telomeres and induces G1 cell cycle arrest in A549 cells
    Ping Yuan
    Department of Thoracic Surgery, First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, P R China
    Oncol Lett 8:1009-1016. 2014
    b>Telomerase Cajal body protein 1 (TCAB1) is a telomerase holoenzyme, which is markedly enriched in Cajal bodies (CBs) and facilitates the recruitment of telomerase to CBs in the S phase of the cell cycle...
  26. pmc The prognostic factors and multiple biomarkers in young patients with colorectal cancer
    Mo jin Wang
    1 Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China 2 Department of Oncology, and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, SE 58183, Sweden
    Sci Rep 5:10645. 2015
    ..The PRL (HR = 12.341, 95% CI = 1.615-94.276, P = 0.010), RBM3 (HR = 0.093, 95% CI = 0.012-0.712, P = 0.018), Wrap53 (HR = 1.952, 95% CI = 0.452-6.342, P = 0.031), p53 (HR = 5.549, 95% CI = 1.176-26.178, P = 0...
  27. pmc Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle
    Jacob M Vogan
    From the Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720
    J Biol Chem 290:21320-35. 2015
    ..In contrast, the telomerase holoenzyme Cajal body-associated protein, TCAB1, was released from hTR in mitotic cells coincident with TCAB1 delocalization from Cajal bodies...
  28. pmc Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome
    E Hedstrom
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cell Death Dis 6:e1892. 2015
    Alterations in the scaffold protein WRAP53β have previously been linked to carcinogenesis and, in particular, associated with an increased risk for epithelial ovarian cancer...
  29. doi Investigation of long noncoding RNAs expression profile as potential serum biomarkers in patients with hepatocellular carcinoma
    Marwa M Kamel
    Oncology Diagnostic Unit, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Transl Res 168:134-45. 2016
    ..is to assess lncRNA-urothelial carcinoma associated-1 (lncRNA-UCA1) and WD repeat containing, antisense to TP53 (WRAP53) expression as novel noninvasive biomarkers for diagnosis of HCC in sera of HCC patients compared with chronic ..
  30. pmc The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1
    Hanif Rassoolzadeh
    a Department of Oncology Pathology Cancer Centrum Karolinska CCK Karolinska Institutet Stockholm, Sweden
    Nucleus 6:417-24. 2015
    We recently demonstrated that WRAP53β acts as a key regulator of ubiquitin-dependent repair of DNA double-strand breaks...
  31. pmc Overexpression of WDR79 in non-small cell lung cancer is linked to tumour progression
    Yang Sun
    Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Molecular Engineering for Theranostics, Hunan University, Changsha, Hunan, China
    J Cell Mol Med 20:698-709. 2016
    WD-repeat protein 79 (WDR79), a member of the WD-repeat protein family, acts as a scaffold protein, participating in telomerase assembly, Cajal body formation and DNA double-strand break repair...
  32. pmc Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization
    Jorge Mata-Garrido
    Departamento de Anatomía y Biología Celular and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Universidad de Cantabria IDIVAL, Avda Cardenal Herrera Oria s n, Santander, Spain
    Acta Neuropathol Commun 4:41. 2016
    ..The latter concentrate DNA damage signaling and repair factors, including γH2AX, pATM, WRAP53 and 53BP1. The number and size of PDDF was dependent on the doses of IR administered...
  33. pmc SMN and coilin negatively regulate dyskerin association with telomerase RNA
    Aaron R Poole
    Department of Biochemistry, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Biol Open 5:726-35. 2016
    ..CBs also contribute to the delivery of telomerase to telomeres. The protein WRAP53 is enriched within the CB and is instrumental for the targeting of telomerase RNA to CBs...
  34. pmc Identification of processing elements and interactors implicate SMN, coilin and the pseudogene-encoded coilp1 in telomerase and box C/D scaRNP biogenesis
    Aaron R Poole
    a Department of Biochemistry, The University of Mississippi Medical Center, Jackson, MS, USA
    RNA Biol 13:955-972. 2016
    ..The CB contains many proteins, including WRAP53, SMN and coilin, the CB marker protein...
  35. pmc Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies
    Jacob M Vogan
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States
    elife 5:. 2016
    ..by minimized telomerase was unaffected by the elimination of the telomerase holoenzyme Cajal body chaperone TCAB1 or the Cajal body scaffold protein Coilin...
  36. doi Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis
    H Y Cao
    Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
    Genet Mol Res 15:. 2016
    The TP53 5'-untranslated region flanking the gene WRAP53 (also known as WDR79 and TCAB1) has been hypothesized to be associated with cancer risk due to its critical function in regulating p53 levels...
  37. ncbi Challenges of CRISPR/Cas9 applications for long non-coding RNA genes
    Ashish Goyal
    Division of RNA Biology and Cancer, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Nucleic Acids Res . 2016
    ..For example, the tumor suppressor TP53 and its head-to-head neighbor WRAP53 are jointly affected by the same sgRNAs but not siPOOLs...
  38. ncbi Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response
    Christos Coucoravas
    a Department of Oncology Pathology, Cancer Centrum Karolinska CCK, Karolinska Institutet, Stockholm, Sweden
    RNA Biol . 2016
    ..b>WRAP53β is a multifunctional protein that controls trafficking of factors to Cajal bodies, telomeres and DNA double-..
  39. pmc WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients
    Hong Zhang
    Division of Biomedicine, The Systems Biology Research Center, University of Skovde, Skovde, Sweden
    BMC Cancer 12:294. 2012
    Expression of WRAP53 protein has oncogenic properties and it is up regulated in several types of tumors.
  40. doi Limbal stem cell deficiency in patients with inherited stem cell disorder of dyskeratosis congenita
    Deniz Aslan
    Section of Hematology, Department of Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey
    Int Ophthalmol 32:615-22. 2012
    ..All eight known disease-causing genes in DC (DKC1, TERC, TERT, NOP10, NHP2, TINF2, C16orf57, and TCAB1) were screened for mutations. The family members of the cases were also assessed, when possible...
  41. doi Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma
    Sandra Ortiz-Cuaran
    International Agency for Research on Cancer, Lyon, France
    Genes Chromosomes Cancer 52:912-9. 2013
    ..This domain contains two coding sequences overlapping with TP53 (WRAP53 and Hp53int1) suggesting that sequences in TP53 intron 1 encode transcripts that may modulate R249S mutation rate ..
  42. ncbi Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells
    Jian Min Yuan
    Department of Orthopedics, The First Affiliated Hospital, China
    Asian Pac J Cancer Prev 12:3465-9. 2011
    ..We sought to investigate changes in Wrap53 and p53 levels in an osteosarcoma cell line (U-2OS) exposed to cisplatin and to study apoptosis before and after ..
  43. pmc The relationship between DNA methylation and telomere length in dyskeratosis congenita
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Aging Cell 11:24-8. 2012
    ..an increase in % subtelomeric methylation in DC patients with a telomerase-complex mutation (TERC, TERT, DKC1, or TCAB1) (63.0% in DC vs. 61.8% in relatives, P = 0.03)...
  44. ncbi Overlapping region of p53/wrap53 transcripts: mutational analysis and sequence similarity with microRNA-4732-5p
    Nasser Pouladi
    Department of Cellular and Molecular Biology, School of Biology, College of Sciences, University of Tehran, Tabriz, Iran
    Asian Pac J Cancer Prev 14:3503-7. 2013
    ..The wrap53α transcript is one of those that acts as a natural antisense agent, forming RNA-RNA hybrids with p53 mRNA and ..
  45. doi Transcriptional and epigenetic regulation of the p53 tumor suppressor gene
    Ricardo Saldaña-Meyer
    Instituto de Fisiologia Celular, Departamento de Genetica Molecular, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    Epigenetics 6:1068-77. 2011
    ..p53 gene expression is tightly controlled through a variety of transcription factors, miRNAs, its anti-sense RNA Wrap53, the insulator protein CTCF and very likely by other genetic and epigenetic mechanisms...
  46. ncbi Vectorettes for long chromosome walking in genomic DNA of the human p53 gene
    Jens Laitinen
    University of Helsinki, Helsinki, Finland
    Biotechniques 37:674-6, 678. 2004
    ..We further sequenced the 5' region of the p53 gene and found that the nucleotides upstream of -1009 are transcribed in antisense orientation into a messenger RNA (mRNA) (flj10385) encoding a putative serine/threonine kinase...
  47. doi Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers
    Caihong Xing
    Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China
    Environ Mol Mutagen 54:397-405. 2013
    ..associated with benzene-induced hematotoxicity (BLM, CYP1A1, EPHX1, ERCC3, NQO1, NUDT1, p15, p16, RAD51, TP53 and WRAP53) in 77 benzene-exposed workers and 25 unexposed controls in China...
  48. pmc Association of common WRAP 53 variant with ovarian cancer risk in the Polish population
    Krzysztof Medrek
    Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
    Mol Biol Rep 40:2145-7. 2013
    ..b>WRAP53 which overlaps the TP53 is required to maintain normal levels of p53 upon DNA damage, but also when altered may ..
  49. pmc Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs
    Beata E Jady
    Laboratoire de Biologie Moleculaire Eucaryote du CNRS, UMR5099, IFR109 CNRS, Universite Paul Sabatier, 31062 Toulouse Cedex 9, France
    Genes Dev 26:1897-910. 2012
    ..the 3' hairpin of AluACA RNAs carries two closely spaced CB localization motifs, CAB boxes (UGAG), which bind Wdr79 in a cumulative fashion...
  50. doi A bidirectional promoter reporter vector for the analysis of the p53/WDR79 dual regulatory element
    Amanda Polson
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, United States
    Plasmid 66:169-79. 2011
    ..Recently, the p53 tumor suppressor gene was shown to have a bidirectional gene partner, WDR79. The transcription start sites (TSSs) of human and murine p53 and WDR79 genes are separated by approximately 800 ..
  51. pmc Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 30:50-8. 2009
    ..Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and WRN) that play a critical role in DNA repair and genomic maintenance, and these regions were then further ..
  52. pmc A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles
    Kazimierz T Tycowski
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Mol Cell 34:47-57. 2009
    ..Its human homolog, WDR79, associates with C/D, H/ACA, and mixed domain scaRNAs, as well as with telomerase RNA...
  53. doi The diversity profile of TP53 is influenced by positive selection on the immediately upstream locus WDR79
    Santos Alonso
    Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Barrio Sarriena s n, ES 48940 Leioa, Bizkaia, Spain
    Hum Hered 69:34-44. 2010
    ..Thus, one might argue that this single central node network lacks robustness. Therefore, we wanted to investigate if natural selection has played a role in shaping the genomic region containing TP53...
  54. pmc Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo
    Emily D Egan
    Department of Molecular and Cell Biology, 331 LSA, University of California, Berkeley, CA 94720 3200, USA
    Mol Cell Biol 30:2775-86. 2010
    ..Fourth, we address a difference in predicted specificities of hTR association with the holoenzyme subunit WDR79/TCAB1...
  55. doi Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms
    M Bug
    Department of Molecular Oncology, Göttingen Center of Molecular Biosciences GZMB, Ernst Caspari Haus, University of Gottingen, Gottingen, Germany
    Oncogene 30:3612-24. 2011
    ..Instead, a natural antisense transcript of TP53, WRAP53, was strongly augmented by idarubicin and etoposide, but only less so by the other anthracyclines under study...
  56. pmc Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
    Luis F Z Batista
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 474:399-402. 2011
    ..In iPSCs from a form of dyskeratosis congenita caused by mutations in TCAB1 (also known as WRAP53), telomerase catalytic activity is unperturbed, yet the ability of telomerase to lengthen telomeres is abrogated, ..
  57. pmc An inducible nuclear body in the Drosophila germinal vesicle
    Alison B Singer
    Department of Embryology, Carnegie Institution for Science, Baltimore MD, USA
    Nucleus 2:403-9. 2011
    ..Induced bodies are formed in GVs of flies that are null for coilin or WDR79, proteins that are required for formation of Cajal bodies (CBs)...
  58. doi Dyskeratosis congenita
    Inderjeet Dokal
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Hematology Am Soc Hematol Educ Program 2011:480-6. 2011
    ..15 years have led to significant advances, with 8 DC genes (DKC1, TERC, TERT, NOP10, NHP2, TIN2, C16orf57, and TCAB1) having been characterized...
  59. ncbi Screening for TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a complete deletion of the TP53 gene
    Gaelle Bougeard
    INSERM EMI 9906 IFRMP, Faculty of Medicine, Rouen, France
    Oncogene 22:840-6. 2003
    ..We conclude that TP53 germline rearrangements occur as rare events, but must be considered in LFS families without detectable point TP53 mutation...

Research Grants3

  1. Steven E Artandi; Fiscal Year: 2014
    ..Through this approach, we identified a new component of the telomerase holoenzyme, termed TCAB1, for Telomerase Cajal Body Protein 1. TCAB1 associates with all active telomerase enzyme and associates with all TERC in human cell ..
  2. Steven E Artandi; Fiscal Year: 2015
    ..In the final steps in the pathway, the telomerase protein TCAB1 enables telomerase accumulation within Cajal bodies, sites of ribonucleoprotein assembly and modification...