WIZ

Summary

Gene Symbol: WIZ
Description: widely interspaced zinc finger motifs
Alias: ZNF803, protein Wiz, WIZ zinc finger, widely-interspaced zinc finger-containing protein, zinc finger protein 803
Species: human

Top Publications

  1. pmc Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse
    Luke Isbel
    Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Melbourne, Australia
    elife 5:. 2016
  2. doi Reader interactome of epigenetic histone marks in birds
    Alina Bluhm
    Institute of Molecular Biology IMB, Mainz, Germany
    Proteomics 16:427-36. 2016
  3. pmc A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin
    Jeremy M Simon
    From the Carolina Institute for Developmental Disabilities, Department of Cell Biology and Physiology, and the Department of Genetics, Curriculum in Bioinformatics and Computational Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
    J Biol Chem 290:26088-102. 2015
  4. pmc The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression
    Chunjing Bian
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States
    elife 4:. 2015
  5. pmc Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
    Jean Philippe P Theurillat
    The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA Harvard Medical School, Boston, MA 02115, USA Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 346:85-9. 2014
  6. pmc A proteomic characterization of factors enriched at nascent DNA molecules
    Andrés J López-Contreras
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid 28029, Spain
    Cell Rep 3:1105-16. 2013
  7. doi Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12
    Markus Draaken
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Birth Defects Res A Clin Mol Teratol 97:133-9. 2013
  8. pmc A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells
    Frederic Galisson
    CNRS FRE3238, Institut Andre Lwoff, Villejuif, France
    Mol Cell Proteomics 10:M110.004796. 2011
  9. doi Identification of non-histone substrates for JMJD2A-C histone demethylases
    V K Chaithanya Ponnaluri
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108 2718, USA
    Biochem Biophys Res Commun 390:280-4. 2009
  10. pmc Building better guidelines with BRIDGE-Wiz: development and evaluation of a software assistant to promote clarity, transparency, and implementability
    Richard N Shiffman
    Yale Center for Medical Informatics, New Haven, Connecticut, USA
    J Am Med Inform Assoc 19:94-101. 2012

Research Grants

  1. Improving Guideline Development and Implementation
    Richard N Shiffman; Fiscal Year: 2010

Scientific Experts

  • Richard Shiffman
  • Cem Zeki Esenyel
  • V V Levenson
  • Sujin Bao
  • Xiaojing Yuan
  • Kazumasa Matsumoto-Miyai
  • Arunkumar Dhayalan
  • Philipp Rathert
  • Luke Isbel
  • Alina Bluhm
  • Chunjing Bian
  • Jeremy M Simon
  • Jean Philippe P Theurillat
  • Markus Draaken
  • Andrés J López-Contreras
  • Frederic Galisson
  • V K Chaithanya Ponnaluri
  • Eva Barrio
  • Albert Jeltsch
  • M Kuppuswamy
  • Yoichi Shinkai
  • Jun Ueda
  • Stephanie J Namciu
  • Marion Scheibe
  • Matthew W Hale
  • Emma Whitelaw
  • Harald Oey
  • Falk Butter
  • Lexie Prokopuk
  • Alex Spurling
  • Lucia Daxinger
  • Núria Casas-Vila
  • Haoyu Wu
  • Adam J Lawther
  • Joel S Parker
  • Samantha G Pattenden
  • Jian Jin
  • Brian D Strahl
  • Amber L Mosley
  • Slimane Ait-Si-Ali
  • Qiang Chen
  • Feng Liu
  • Ian J Davis
  • Scott B Rothbart
  • Xiaochun Yu
  • Anna C Groner
  • Corinna Baust
  • Levi A Garraway
  • Marius Pop
  • Namrata D Udeshi
  • Sylvan C Baca
  • Gilbert G Prive
  • Mark A Rubin
  • Peter J Wild
  • Holger Moch
  • Steven A Carr
  • Tanya Svinkina
  • Wesley J Errington
  • Mirjam Blattner
  • Raimund Stein
  • Tracie Pennimpede
  • Dominik Schmidt
  • Enrika Bartels
  • Lars Wittler
  • Isabel Ruppen
  • Bernhard G Herrmann
  • Markus M Nothen
  • Stefanie Wolter
  • Javier Munoz
  • Wolfgang Rösch
  • Heiko Reutter
  • Matilde Murga
  • Anne Karoline Ebert
  • Silvia Remeseiro
  • Michael Ludwig
  • Sadaf S Mughal
  • Sara Rodríguez-Acebes
  • Susanne Moebus
  • Per Hoffmann
  • Ana M Rojas
  • Maria Nieto-Soler
  • Sara Rodrigo-Perez
  • Juan Mendez
  • Oscar Fernandez-Capetillo
  • Thomas M Boemers
  • Eberhard Schmiedeke
  • Mounira K Chelbi-Alix
  • Louiza Mahrouche
  • Eric Bonneil
  • Sylvain Meloche

Detail Information

Publications23

  1. pmc Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse
    Luke Isbel
    Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Melbourne, Australia
    elife 5:. 2016
    We previously identified Wiz in a mouse screen for epigenetic modifiers. Due to its known association with G9a/GLP, Wiz is generally considered a transcriptional repressor...
  2. doi Reader interactome of epigenetic histone marks in birds
    Alina Bluhm
    Institute of Molecular Biology IMB, Mainz, Germany
    Proteomics 16:427-36. 2016
    ..The repressive marks are bound by the HP1 proteins and the EED subunit of the PRC2 complex as well as by WIZ. Like reported in the previous mammalian screens, we found ZNF462, ZNF828 and POGZ enriched at H3K9me3...
  3. pmc A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin
    Jeremy M Simon
    From the Carolina Institute for Developmental Disabilities, Department of Cell Biology and Physiology, and the Department of Genetics, Curriculum in Bioinformatics and Computational Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
    J Biol Chem 290:26088-102. 2015
    ..Widely interspaced zinc finger (WIZ) associates with the G9a-GLP protein complex, but its role in mediating lysine methylation is poorly defined...
  4. pmc The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression
    Chunjing Bian
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States
    elife 4:. 2015
    ..In this study, with unbiased protein affinity purification, we found ZNF644 and WIZ as two core subunits in the G9a/GLP complex...
  5. pmc Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
    Jean Philippe P Theurillat
    The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA Harvard Medical School, Boston, MA 02115, USA Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 346:85-9. 2014
    ..DEK stabilization promoted prostate epithelial cell invasion, which implicated DEK as an oncogenic effector. More generally, these results provide a framework to decipher tumorigenic mechanisms linked to dysregulated ubiquitylation. ..
  6. pmc A proteomic characterization of factors enriched at nascent DNA molecules
    Andrés J López-Contreras
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid 28029, Spain
    Cell Rep 3:1105-16. 2013
    ..This resource provides a panoramic view of the proteins that concentrate in the surroundings of the replisome, which should facilitate future investigations on DNA replication and genome maintenance...
  7. doi Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12
    Markus Draaken
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Birth Defects Res A Clin Mol Teratol 97:133-9. 2013
    ..In this study, we aimed to identify de novo causative copy number variations (CNVs) that contribute to the BEEC...
  8. pmc A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells
    Frederic Galisson
    CNRS FRE3238, Institut Andre Lwoff, Villejuif, France
    Mol Cell Proteomics 10:M110.004796. 2011
    ....
  9. doi Identification of non-histone substrates for JMJD2A-C histone demethylases
    V K Chaithanya Ponnaluri
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108 2718, USA
    Biochem Biophys Res Commun 390:280-4. 2009
    ..substrate, trimethylated histone H3-lysine-9, JMJD2A-C demethylate trimethylated lysine containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes...
  10. pmc Building better guidelines with BRIDGE-Wiz: development and evaluation of a software assistant to promote clarity, transparency, and implementability
    Richard N Shiffman
    Yale Center for Medical Informatics, New Haven, Connecticut, USA
    J Am Med Inform Assoc 19:94-101. 2012
    ....
  11. doi Coi-wiz: An interactive computer wizard for analyzing cardiac optical signals
    Xiaojing Yuan
    University of Houston, Houston, TX 77024 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:1828-31. 2009
    ..The interactive GUI allows the researcher to identify the region of interest in both the spatial and temporal domain, thus enabling them to study different heart chamber at their choice...
  12. doi [Evaluation of soft tissue reactions to three nonabsorbable suture materials in a rabbit model]
    Cem Zeki Esenyel
    Department of Orthopedics and Traumatology, Vakif Gureba Training and Research Hospital, Istanbul, Turkey
    Acta Orthop Traumatol Turc 43:366-72. 2009
    ..We evaluated the inflammatory reactions induced by three commonly used nonabsorbable suture materials in a rabbit model...
  13. ncbi Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11
    B Funke
    Department of Molecular Genetics, Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Genomics 53:146-54. 1998
    ..The pattern of expression of NLVCF and its localization in the critical region suggest that NLVCF may contribute to the etiology of VCFS...
  14. doi A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening
    Arunkumar Dhayalan
    Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
    J Biomol Screen 14:1129-33. 2009
    ..a continuous protein methylation assay using the G9a protein lysine methyltransferase and its substrate protein WIZ (widely interspaced zinc finger motifs)...
  15. ncbi Study of apoptosis and related proteins, CRH and hpGH in placentas of newborns small for gestational age (SGA)
    Eva Barrio
    Molecular Genetics Lab Uni Hosp Miguel Servet, Zaragoza, Spain
    Pediatr Endocrinol Rev 6:337-42. 2009
    ..In addition we have demonstrated this expression by immunohistochemical techniques...
  16. pmc Protein lysine methyltransferase G9a acts on non-histone targets
    Philipp Rathert
    Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    Nat Chem Biol 4:344-6. 2008
    ..Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB...
  17. pmc Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex
    M Kuppuswamy
    Institute for Molecular Virology, Saint Louis University School of Medicine, Daisy Research Center, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 28:269-81. 2008
    ..The auxiliary components include an HMTase complex (G9a/Wiz/CDYL) and two SUMO E3 ligases, HPC2 and PIAS1...
  18. pmc Fast cloning inverted repeats for RNA interference
    Sujin Bao
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    RNA 12:2020-4. 2006
    ..Here we describe a pGEM-T-based vector, pGEM-WIZ, designed to produce inverted repeats for any Drosophila gene...
  19. ncbi Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP
    Jun Ueda
    Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Japan
    J Biol Chem 281:20120-8. 2006
    ..We identified a novel G9a/GLP-associating zinc finger molecule named Wiz that can interact with G9a and GLP independently but is more stable in the G9a/GLP heteromeric complexes...
  20. ncbi Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1
    Stephanie J Namciu
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A2 O25, Seattle, Washington 98109 1024, USA
    Mamm Genome 15:162-78. 2004
    ..of the region, sequences with putative nuclear matrix-binding potential were identified by using the MAR-Wiz algorithm, and these MAR-Wiz candidate sequences were tested for nuclear matrix-binding activity in vitro...
  21. ncbi Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice
    Corinna Baust
    Terry Fox Laboratory, B C Cancer Agency, 601 West 10th Ave, Vancouver, BC V5Z 1L3 Canada
    Mamm Genome 13:423-8. 2002
    ..ETn I has not been found to be the cause of any mutations, prompting the suggestion that ETn II is the "mobile" family, whereas ETn I elements have lost the capacity to retrotranspose...
  22. ncbi A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication
    V V Levenson
    Department of Molecular Genetics, University of Illinois at Chicago 60607 7170, USA
    Somat Cell Mol Genet 25:9-26. 1999
    ..The four GSEs were derived from ORFX bromodomain protein gene, WIZ zinc finger protein gene, the gene for subunit 3 of cytochrome c oxidase, and the gene corresponding to an EST with no ..
  23. ncbi Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum
    K Matsumoto
    Division of Structural Cell Biology, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    Brain Res Mol Brain Res 61:179-89. 1998
    ..Since both mRNAs encode proteins with widely-interspaced zinc finger motifs, we termed this gene wiz and refer to the short and long wiz transcripts as wizS and wizL, respectively...

Research Grants1

  1. Improving Guideline Development and Implementation
    Richard N Shiffman; Fiscal Year: 2010
    ..In addition, the proposed activities focus on systems that will preferentially impact children - a particularly vulnerable population. ..