Gene Symbol: WDTC1
Description: WD and tetratricopeptide repeats 1
Alias: ADP, DCAF9, WD and tetratricopeptide repeats protein 1, DDB1 and CUL4 associated factor 9, adipose homolog
Species: human

Top Publications

  1. pmc Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo-
    A C Chao
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA 94305 5246
    Br J Pharmacol 112:169-75. 1994
  2. pmc Control of triglyceride storage by a WD40/TPR-domain protein
    Thomas Häder
    DeveloGen AG, Rudolf Wissell Strasse 28, 37079 Göttingen, Germany
    EMBO Rep 4:511-6. 2003
  3. pmc WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:593-600. 2009
  4. pmc Antiproliferative effects of A02011-1, an adenylyl cyclase activator, in cultured vascular smooth muscle cells of rat
    S M Yu
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 114:1227-35. 1995
  5. pmc Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells
    J Pfeilschifter
    Department of Pharmacology, University of Basel, Switzerland
    Br J Pharmacol 110:847-53. 1993
  6. ncbi Protein synthesis, cellular amino acids, and energy levels in CAPD patients
    J Metcoff
    University of Oklahoma Health Sciences Center, Oklahoma City
    Kidney Int Suppl 22:S136-44. 1987
  7. ncbi Lipid peroxidation and cancer: a critical reconsideration
    M U Dianzani
    Department of Experimental Medicine and Oncology, University of Turin, Italy
    Tumori 75:351-7. 1989
  8. pmc Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency
    A T Dinh Xuan
    Department of Respiratory Physiology, Papworth Hospital, Cambridge
    Br J Pharmacol 109:587-91. 1993
  9. pmc The effect of defibrotide on thromboembolism in the pulmonary vasculature of mice and rabbits and in the cerebral vasculature of rabbits
    W Paul
    Department of Pharmacology, King s College, University of London
    Br J Pharmacol 110:1565-71. 1993
  10. pmc Evidence for P2-purinoceptor-mediated inhibition of noradrenaline release in rat brain cortex
    I von Kugelgen
    Pharmakologisches Institut, Freiburg, Germany
    Br J Pharmacol 113:815-22. 1994

Research Grants

    Sufan Chien; Fiscal Year: 2013
  2. Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP Synthase
    Zulfiqar Ahmad; Fiscal Year: 2009
  3. Role and Mechanism of ATP Hydrolysis in Actin
    Isaiah Sumner; Fiscal Year: 2012
  4. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2010
  5. IVAN B YANACHKOV; Fiscal Year: 2015
  6. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
  7. Hening Lin; Fiscal Year: 2016
  8. Hening Lin; Fiscal Year: 2016
  9. Joshua A Boyce; Fiscal Year: 2016
  10. Derek C Molliver; Fiscal Year: 2016

Detail Information

Publications1011 found, 100 shown here

  1. pmc Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo-
    A C Chao
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA 94305 5246
    Br J Pharmacol 112:169-75. 1994
    ..The rank order of potency of purinoceptor agonists in stimulating 125I efflux was ADO > AMP > ADP approximately equal to ATP...
  2. pmc Control of triglyceride storage by a WD40/TPR-domain protein
    Thomas Häder
    DeveloGen AG, Rudolf Wissell Strasse 28, 37079 Göttingen, Germany
    EMBO Rep 4:511-6. 2003
    ..Here, we report the identification of the adipose (adp) gene, the mutation of which causes obesity in Drosophila...
  3. pmc WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:593-600. 2009
    ..We investigated the correlation between genetic variation of the WDTC1 locus, the ortholog of adp, and human obesity...
  4. pmc Antiproliferative effects of A02011-1, an adenylyl cyclase activator, in cultured vascular smooth muscle cells of rat
    S M Yu
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 114:1227-35. 1995
    ..foetal calf serum (FCS, 10%), platelet-derived growth factor (PDGF, 10 ng ml-1), 5-hydroxytryptamine (10 microM) or ADP (10 microM). The inhibitory effect of A02011-1 was fully reversible...
  5. pmc Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells
    J Pfeilschifter
    Department of Pharmacology, University of Basel, Switzerland
    Br J Pharmacol 110:847-53. 1993
    ..stimulation of phosphatidylethanol formation was UTP = ATP > ITP > ATP gamma S > beta gamma-imido-ATP = ADP > 2-methylthio-ATP = beta gamma-methylene-ATP = ADP beta S, while AMP, adenosine, CTP and GTP were inactive, ..
  6. ncbi Protein synthesis, cellular amino acids, and energy levels in CAPD patients
    J Metcoff
    University of Oklahoma Health Sciences Center, Oklahoma City
    Kidney Int Suppl 22:S136-44. 1987
    Cellular energy-related bioactivities [energy charge = ATP + 0.5 ADP/(ATP + ADP + AMP)], enzyme activities adenylate kinase, pyruvate kinase, phosphofructokinase, glucose-6-phosphate dehydrogenase, free amino acids in plasma and cells, ..
  7. ncbi Lipid peroxidation and cancer: a critical reconsideration
    M U Dianzani
    Department of Experimental Medicine and Oncology, University of Turin, Italy
    Tumori 75:351-7. 1989
    ..independently of the extent of the loss of peroxidation in basal conditions, is the lack of further stimulation by ADP/iron or by ascorbate/iron...
  8. pmc Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency
    A T Dinh Xuan
    Department of Respiratory Physiology, Papworth Hospital, Cambridge
    Br J Pharmacol 109:587-91. 1993
    ..COLD patients and 8 controls to the endothelium-dependent vasodilators acetylcholine (ACh), adenosine diphosphate (ADP), and the calcium ionophore, A23187...
  9. pmc The effect of defibrotide on thromboembolism in the pulmonary vasculature of mice and rabbits and in the cerebral vasculature of rabbits
    W Paul
    Department of Pharmacology, King s College, University of London
    Br J Pharmacol 110:1565-71. 1993
    ..v. thrombin. In contrast, platelet accumulation in response to adenosine diphosphate (ADP; 20 micrograms kg-1, i.v.) or platelet activating factor (PAF; 50 ng kg-1, i.v...
  10. pmc Evidence for P2-purinoceptor-mediated inhibition of noradrenaline release in rat brain cortex
    I von Kugelgen
    Pharmakologisches Institut, Freiburg, Germany
    Br J Pharmacol 113:815-22. 1994
    ..microM), adenosine-5'-O-(3-thiotriphosphate) (ATP gamma S; 30-300 microM), adenosine-5'-O-(2-thiodiphosphate) (ADP beta S; 30-300 microM), P1,P4-di(adenosine-5')-tetraphosphate (Ap4A; 30-300 microM) and the preferential P2Y-..
  11. ncbi Potassium augments vascular relaxation mediated by nitric oxide in the carotid arteries of hypertensive Dahl rats
    M S Zhou
    2nd Department of Physiology, Kagawa Medical University, Kida, Japan
    Am J Hypertens 13:666-72. 2000
    ..In norepinephrine-precontracted rings, the relaxation in response to acetylcholine, adenosine 5'-diphosphate (ADP), and isoproterenol were significantly attenuated in hypertensive Dahl rats, which was improved by potassium ..
  12. ncbi Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites
    M Boll
    Institute of Toxicology, GSF National Research Center for Environment and Health, , Neuherberg, Germany
    Z Naturforsch C 56:649-59. 2001
    ..b>ADP-Fe3+ and cumol hydroperoxide, respectively...
  13. pmc Endothelial function in spontaneously hypertensive rats: influence of quinapril treatment
    M Kahonen
    Medical School, Department of Pharmacology, University of Tampere, Finland
    Br J Pharmacol 115:859-67. 1995
    ..relaxations of noradrenaline (NA)-precontracted rings to acetylcholine (ACh) and adenosine 5'-diphosphate (ADP) were similar in WKY rats and quinapril-treated SHR and more pronounced than in untreated SHR...
  14. pmc Modulation by nicotinamide adenine dinucleotide of sympathetic and sensory-motor neurotransmission via P1-purinoceptors in the rat mesenteric arterial bed
    V Ralevic
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 114:1541-8. 1995
    ..dinucleotide (NAD), beta-nicotinamide adenine dinucleotide phosphate (beta-NADP), adenosine 5'-diphosphoribose (ADP-ribose), the vitamin nicotinamide and structural analogues of NAD and NADP were tested in the isolated perfused ..
  15. pmc Characteristics of nucleotide receptors that cause elevation of cytoplasmic calcium in immortalized rat brain endothelial cells (RBE4) and in primary cultures
    M Nobles
    King s College London, Biomedical Sciences Division, Strand
    Br J Pharmacol 115:1245-52. 1995
    ..involved belongs to the P2 subtype, since the agonist potency order among the adenine nucleotides was ATP > ADP > AMP...
  16. pmc P2-purinoceptor-mediated inhibition of noradrenaline release in rat atria
    I von Kugelgen
    Pharmakologisches Institut, Universitat Freiburg, Germany
    Br J Pharmacol 115:247-54. 1995
    ..curve of ATP was not changed by indomethacin, atropine or the 5'-nucleotidase blocker alpha, beta-methylene-ADP. 4. Cibacron blue 3GA (30 microM) increased the evoked overflow of tritium by about 70%...
  17. pmc Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells
    C Schwanstecher
    Institute of Pharmacology and Toxicology, , Germany
    Br J Pharmacol 107:87-94. 1992
    ..prevented the complete channel block induced by saturating tolbutamide concentrations in the presence of Mg2+ and ADP (1 mM). 6...
  18. pmc FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors
    R G Humphries
    Department of Pharmacology, Fisons plc, Loughborough, Leics
    Br J Pharmacol 113:1057-63. 1994
    1. ADP-dependent platelet aggregation is mediated by the P2T-purinoceptor and is specifically inhibited by ATP, which is a competitive P2T-purinoceptor antagonist...
  19. pmc Gi proteins and the response to 5-hydroxytryptamine in porcine cultured endothelial cells with impaired release of EDRF
    N S Day
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Br J Pharmacol 115:822-7. 1995
    ..kDa, which corresponded to the Gi alpha 2 and the combination of Gi alpha 3-Gi alpha 1 proteins, respectively, were ADP-ribosylated by pertussis toxin...
  20. ncbi Nicotinamide and 3-aminobenzamide reduce interferon-gamma-induced class II MHC (HLA-DR and -DP) molecule expression on cultured human endothelial cells and fibroblasts
    A Otsuka
    Second Department of Internal Medicine, Osaka University Medical School, Japan
    Immunopharmacol Immunotoxicol 13:263-80. 1991
    We investigated the effects of nicotinamide and 3-aminobenzamide, known as inhibitors of poly (ADP-ribose) synthetase, on the expression of interferon- gamma (IFN-gamma)-induced class I and II major histocompatibility complex (MHC) ..
  21. pmc Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells
    A Huwiler
    Department of Pharmacology, University of Basel, Switzerland
    Br J Pharmacol 113:1455-63. 1994
    ..beta gamma-imido-ATP was somewhat less active and ADP and 2-methylthio-ATP caused a weak induction of enzyme activity...
  22. pmc ZD1542, a potent thromboxane A2 synthase inhibitor and receptor antagonist in vitro
    R P Brownlie
    Vascular Inflammatory and Musculoskeletal Research Department, Zeneca Pharmaceuticals, Macclesfield, Cheshire
    Br J Pharmacol 110:1600-6. 1993
    ..up to 100 microM, it did not modify 5-hydroxytryptamine (5-HT) or the primary phases of adenosine diphosphate (ADP) and adrenaline-induced aggregation...
  23. pmc Contractile effects of uridine 5'-triphosphate in the rat duodenum
    C R Johnson
    Receptors and Cellular Regulation Research Group, School of Biological Sciences, University of Surrey, Guildford
    Br J Pharmacol 113:1191-6. 1994
    ..2. ATP, UTP, adenosine 5'-diphosphate (ADP), adenosine 5'-O-(3-thiotriphosphate) (ATP-gamma-S), guanosine 5'-triphosphate (GTP) and uridine 5'-diphosphate (..
  24. ncbi Isolation, characterization, and substrate specificity of the plasma membrane ATPase of the hlophilic achaeon Haloferax volcanii
    K Steinert
    , , Bundesrepublik Deutschland
    Z Naturforsch C 51:29-39. 1996
    ..Sodium chloride concentrations in the molar range induce changes in KM by a factor of about 10. The enzyme is specific for ATP; other nucleotides including GTP and ADP are competitive inhibitors of ATP hydrolysis.
  25. ncbi Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta
    J M Bocker
    Department of Internal Medicine, University of Iowa Hospitals, Iowa City, USA
    Jpn Heart J 42:317-26. 2001
    ..After contraction with prostaglandin F2alpha, relaxation to thrombin, adenosine diphosphate (ADP), or the endothelium-independent agonists, sodium nitroprusside (SNP) or papaverine was examined...
  26. ncbi Alterations in erythrocyte plasma membrane ATPase activity and adenine nucleotide content in a spontaneously diabetic subline of the Chinese hamster
    D Bettin
    , Greifswald, Germany
    Horm Metab Res 28:1-6. 1996
    ..Both ATP and ADP content were lower in erythrocytes from diabetic than nondiabetic hamsters...
  27. ncbi Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi alpha) in spontaneously hypertensive rats
    M B Anand-Srivastava
    , , Canada
    Am J Hypertens 4:840-3. 1991
    ..In the present studies we have examined the activity of GTP-binding proteins (G-proteins) at ADP-ribosylation level, by using pertussis toxin (PT) and cholera toxin (CT) at protein level, by using specific ..
  28. ncbi Vasoactive mediators derived from the endothelium
    R Botting
    William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, UK
    Arch Mal Coeur Vaiss 82:11-4. 1989
    ..Substances which stimulate release of EDRF include acetylcholine, bradykinin and ADP. EDRF is even more labile than prostacyclin with a half life counted in seconds...
  29. pmc Cross-linking myosin subfragment 1 Cys-697 and Cys-707 modifies ATP and actin binding site interactions
    K Kirshenbaum
    Department of Biochemistry, University of the Pacific School of Dentistry, San Francisco, California 94115 2399
    Biophys J 65:1121-9. 1993
    ..Chemical cross-linking with N,N'-p-phenylenedimaleimide (pPDM) of Cys-697 to Cys-707 of the myosin-ADP complex eliminates activity and produces a species that resembles myosin with ATP bound (Burke et al., 1976)...
  30. ncbi Caffeine-DNA interactions: biochemical investigations comprising DNA-repair enzymes and nucleic acid synthesis
    K Tempel
    , Toxikologie und Pharmazie, , Germany
    Z Naturforsch C 52:466-74. 1997
    ..UDS) DNA synthesis, RNA synthesis (RNS), the activities of O6-alkylguanine-DNA alkyltransferase (AT) and poly (ADP-ribose) polymerase (PARP) as well as nucleoid sedimentation...
  31. pmc A pertussis toxin-sensitive mechanism of endothelin action in porcine coronary artery smooth muscle
    Y Kasuya
    Department of Pharmacology, University of Tsukuba, Ibaraki, Japan
    Br J Pharmacol 107:456-62. 1992
    ..6. We confirmed that the pretreatment of the tissue with PT induced ADP-ribosylation of a 41 kDa membrane protein. 7...
  32. ncbi Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization
    D L Hwang
    Department of Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, California 91010
    Am J Hypertens 5:700-6. 1992
    ..in human platelets (in whole blood, platelet-rich plasma, or washed platelets) against various aggregation agents (ADP, U46619, collagen, or thrombin)...
  33. pmc Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 110:1055-60. 1993
    ..5. Adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate (AMP), adenosine and adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-s; all 1 x 10-6 1 x ..
  34. pmc A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat midbrain synaptosomes
    J Pintor
    Departamento de Bioquimica, Fac Veterinaria, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 115:895-902. 1995
    1. Diadenosine polyphosphates, Ap4A and Ap5A, as well as ATP, alpha,beta-MeATP and ADP-beta-S, were able to elicit variable intrasynaptosomal Ca2+ increases in rat midbrain synaptic terminals...
  35. pmc Selective inhibition of agonist-induced but not shear stress-dependent release of endothelial autacoids by thapsigargin
    H Macarthur
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, Charterhouse Square, London
    Br J Pharmacol 108:100-5. 1993
    ..release of NO from bovine aortic endothelial cells grown on beads, but abolished the release of NO induced by ADP, bradykinin, ionomycin or poly-L-lysine...
  36. pmc Effect of nucleotides on the cytosolic free calcium activity and inositol phosphate formation in human glomerular epithelial cells
    H Pavenstadt
    Medizinische Klinik, Nephrologische Abteilung, Freiburg, Germany
    Br J Pharmacol 107:189-95. 1992
    ..The order of potency for the purine nucleotides in stimulating InsP3 formation was ATP = ATP-gamma-S greater than ADP greater than 2-methylthio-ATP greater than AMP = a,beta methylene-ATP = adenosine. 6...
  37. ncbi Liver metabolism in cold hypoxia: a comparison of energy metabolism and glycolysis in cold-sensitive and cold-resistant mammals
    T A Churchill
    University Department of Surgery, Royal Free Hospital School of Medicine, London, UK
    J Comp Physiol B 164:396-404. 1994
    ..fructose-6-phosphate, fructose-1,6-bisphosphate, phosphoenolpyruvate, pyruvate, lactate and energetics (ATP, ADP, AMP) of livers from rats and columbian ground squirrels...
  38. ncbi Gamma-interferon (IFN-gamma) augments apoptotic response to mistletoe lectin-II via upregulation of Fas/Fas L expression and caspase activation in human myeloid U937 cells
    M S Kim
    Institute of Medical Science, Wonkwang University School of Medicine, Korea
    Immunopharmacol Immunotoxicol 23:55-66. 2001
    ..The activation of caspase-3-like protease requires the earlier cleavage of poly(ADP-ribose) polymerase(PARP)...
  39. pmc Effects of Bordetella pertussis toxin pretreatment on the antiarrhythmic action of ischaemic preconditioning in anaesthetized rats
    L Piacentini
    Department of Physiology and Pharmacology, University of Strathclyde, Glasgow
    Br J Pharmacol 114:755-60. 1995
    1. Bordetella pertussis toxin, which catalyses the ADP-ribosylation of certain guanine nucleotide binding proteins (G proteins), thus functionally uncoupling them from associated receptors, was examined to determine whether it modified ..
  40. ncbi ADP-ribosyltransferase is highly conserved: purification and characterization of ADP-ribosyltransferase from a fish and its comparison with the human enzyme
    H J Burtscher
    , , , Austria
    J Comp Physiol B 157:567-72. 1987
    Covalent modification of proteins by ADP-ribosylation is a major mode of protein regulation in eukaryotic cells. ADP-ribosyltransferases have been characterized from mammals but little is known about these enzymes in lower vertebrates...
  41. pmc Potentiation by adenosine of ATP-evoked dopamine release via a pertussis toxin-sensitive mechanism in rat phaeochromocytoma PC12 cells
    S Koizumi
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Br J Pharmacol 112:992-7. 1994
    ..3. Pertussis toxin (PTX), a bacterial exotoxin which catalyzes the ADP-ribosylation of guanosine 5'-triphosphate (GTP)-binding proteins (G-proteins), inhibited the adenosine-induced ..
  42. pmc Characterization of P2-purinoceptor mediated cyclic AMP formation in mouse C2C12 myotubes
    R H Henning
    Department of Pharmacology Clinical Pharmacology, University of Groningen, The Netherlands
    Br J Pharmacol 110:133-8. 1993
    ..3. Myotubes hydrolysed ATP to ADP at a rate of 9.7 +/- 1.0 nmol mg-1 protein min-1...
  43. ncbi Evidence for cyclic GMP in the yeast Saccharomyces cerevisiae, and studies on its possible role in growth
    H Eckstein
    , Hamburg, Bundesrepublik Deutschland
    Z Naturforsch C 43:386-96. 1988
    ..None of the agents has significant effects on the level of cyclic AMP. The results suggest that cyclic GMP possibly controls an early step of mitosis, whereas ADP-ribosylation might govern a subsequent event.
  44. pmc Long-range interactions in mammalian platelet aggregation. I. Evidence from kinetic studies in brownian diffusion
    K Longmire
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Biophys J 58:299-307. 1990
    ..two-body collisions, was used to obtain collision efficiencies, alpha B, for adenosine diphosphate (ADP)-induced platelet aggregation in citrated platelet-rich plasma (PRP) from humans, dogs, and rabbits...
  45. ncbi [Effects of intravenous nicardipine on blood pressure, hemorheology platelet function in arterial hypertension. Dose-effect relations]
    F Zannad
    , CHRU de Nancy,
    Arch Mal Coeur Vaiss 80:844-50. 1987
    ..3 +/- 3.8 to 13.5 +/- 3.1; p less than 0.01. Platelet aggregation with ADP was unchanged, but aggregation with A 23187 decreased from 46.9 +/- 21.2 to 31.3 +/- 25.6; p less than 0...
  46. pmc Evidence that [3H]-alpha,beta-methylene ATP may label an endothelial-derived cell line 5'-nucleotidase with high affinity
    A D Michel
    Glaxo Institute of Applied Pharmacology, University of Cambridge
    Br J Pharmacol 115:767-74. 1995
    ..sites appeared heterogeneous since in competition studies a number of nucleotide analogues (alpha, beta-meADP, ATP, ADP, AMP, GTP, GppNHp, GMP) and adenosine identified two populations of the sites labelled by 1 nM [3H]-alpha, beta-..
  47. ncbi Rapid separation of particulate components and soluble cytoplasm of isolated rat-liver cells
    P F Zuurendonk
    Laboratory of Biochemistry, B.C.P. Jansen Institute, University of Amsterdam, Plantage Muidergracht 12, Amsterdam, The Netherlands
    Biochim Biophys Acta 333:393-9. 1974
    ..About 60% of total adenine nucleotides in hepatocytes were found in the soluble cytoplasm. The ATP/ADP ratio in the particulate fraction 80 s after exposure to digitonin of hepatocytes metabolizing alanine was 2.0-2...
  48. ncbi [Membrane abnormalities and cellular hyperreactivity in different models of hypertension]
    P Marche
    , INSERM U 7, CNRS URA 318, , Paris
    Arch Mal Coeur Vaiss 83:1175-7. 1990
    ..Likewise, in hypertensive subjects, platelets behave hyperactive when stimulated by ADP, although the stimulus has been demonstrated to be a poor activator of phospholipase C...
  49. pmc Differential regulation of inositol 1,4,5-trisphosphate by co-existing P2Y-purinoceptors and nucleotide receptors on bovine aortic endothelial cells
    J R Purkiss
    Department of Pharmacology and Therapeutics, University of Leicester
    Br J Pharmacol 111:723-8. 1994
    ..the inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) responses in bovine aortic endothelial (BAE) cells to purines (ATP, ADP and analogues) and the pyrimidine, uridine triphosphate (UTP). 2...
  50. pmc Membrane current responses to externally-applied ATP in the longitudinal muscle of the chicken rectum
    T Matsuoka
    Department of Veterinary Science, Faculty of Agriculture, Gifu University, Japan
    Br J Pharmacol 110:87-94. 1993
    ..analogues elicited an inward current and the order of potency was ATP not equal to alpha, beta-methylene ATP > ADP >> AMP. 7. Inclusion of GTP gamma S (0...
  51. pmc Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa
    S Liu
    Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Bacteriol 179:1609-13. 1997
    ..Although ExoS and Exo53 possess 76% primary amino acid homology, Exo53 has been shown to express ADP-ribosyltransferase activity at about 0.2% of the specific activity of ExoS...
  52. ncbi Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension
    R Hernandez Hernandez
    Clinical Pharmacology Unit, School of Medicine, Universidad Centro Occidental Lisandro Alvarado, Barquisimeto, Venezuela
    Am J Hypertens 9:437-44. 1996
    ..Ex vivo platelet aggregation induced by epinephrine, collagen, and adenosine diphosphate (ADP) were carried out twice during the first placebo phase, once at the end of each terazosin dosage, and once in the ..
  53. ncbi Cytotoxic activity of a recombinant chimaeric protein between Pseudomonas aeruginosa exotoxin A and Corynebacterium diphtheriae diphtheria toxin
    C Guidi-Rontani
    , CNRS URA557, Institut Pasteur, Paris, France
    Mol Microbiol 6:1281-7. 1992
    ..Furthermore, the chimaeric protein displayed ADP-ribosylation activity and exhibited cytotoxicity to mouse 3T6 fibroblasts...
  54. pmc Effects of suramin on contractions of the guinea-pig vas deferens induced by analogues of adenosine 5'-triphosphate
    S J Bailey
    School of Biological Sciences, University of Surrey, Guildford
    Br J Pharmacol 114:1125-32. 1995
    ..diphosphonate (AMPPCP) > P1,P5-diadenosine tetraphosphate (Ap4A) > adenosine 5'-O-(2- thiodiphosphate) (ADP beta S) > 2-methylthioadenosine 5'-triphosphate (MeSATP) > or = ATP > adenosine 5'-diphosphate (ADP)...
  55. pmc [Ca2+]i in human heart failure: a review and discussion of current areas of controversy
    R Liao
    Cardiovascular Disease Laboratory, Harvard Medical School, Boston, Massachusetts, USA
    Yale J Biol Med 67:247-64. 1994
    ..g., ADP, inhibit pumps, such as sarcoplasmic reticulum Ca2+ ATPase activity...
  56. pmc Interaction of tolbutamide and cytosolic nucleotides in controlling the ATP-sensitive K+ channel in mouse beta-cells
    C Schwanstecher
    Institute of Pharmacology and Toxicology, , Germany
    Br J Pharmacol 111:302-10. 1994
    ..decreased in the order ATP = adenosine 5'-O-(3-thiotriphosphate) (ATP gamma S) > adenosine 5'-diphosphate (ADP) > adenosine 5'-O-(2-thiodiphosphate) (ADP beta S) = adenylyl-imidodiphosphate (AMP-PNP) > 2'-deoxyadenosine ..
  57. pmc A study on P2X purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens
    B S Khakh
    Glaxo Institute for Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 115:177-85. 1995
    ..3-10 microM), being approximately equipotent with similar concentrations for threshold effects (0.3 microM). ADP (10 microM) also evoked a rapid current of similar peak amplitude to that seen with ATP (10 microM). 3...
  58. ncbi Mechanism of action of maternal serum on the interleukin2 receptor expression
    Y E Vanderbeeken
    Service d'Immunologie, , Brussels, Belgium
    Immunopharmacol Immunotoxicol 14:491-513. 1992
    ..At low concentrations, pertussis toxin lost its stimulating property and retained its ability to ADP ribosylate the alpha subunit of G proteins inducing a release of adenylcyclase mediating cAMP synthesis...
  59. ncbi [Experimental study on pathogenesis of neonatal hypoxic-ischemic encephalopathy. II. Energy metabolism in the brain]
    K Nishizawa
    Department of Pediatrics, Shiga University of Medical Science
    No To Hattatsu 22:459-65. 1990
    ..The contents of the lactate, pyruvate, ADP and ATP were also measured during hypoxia...
  60. ncbi Thyroid hormones and muscle metabolism in dogs
    B Kruk
    Department of Applied Physiology, Polish Academy of Sciences, Warsaw
    Horm Metab Res 20:620-3. 1988
    Muscle contents of ATP, ADP, AMP, creatine phosphate and creatine as well as glycogen, some glycolytic intermediates, pyruvate and lactate were compared in the intact, thyroidectomized and triiodothyronine (T3) treated dogs under resting ..
  61. ncbi Effects of isradipine on platelet function in hypertension at rest and during exercise
    P Fitscha
    Department of Internal Medicine II, Policlinic, Vienna, Austria
    Am J Hypertens 4:178S-180S. 1991
    ..Systolic and diastolic blood pressures, platelet aggregation in response to adenosine diphosphate (ADP), serum thromboxane B2, and beta-thromboglobulin levels were significantly decreased (P less than ...
  62. ncbi Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase
    Alex Grunau
    Department of Biochemistry, University of Leicester, UK
    Biochemistry 45:1421-34. 2006
    ..Binding of 2',5'-ADP, NADP(+), and H(4)NADP, an isosteric NADPH analogue, is described in terms of the dissociation binding constant (K(..
  63. pmc Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals
    J Pintor
    , Universidad Complutense, Madrid, Spain
    Br J Pharmacol 108:1094-9. 1993
    ..Ap4A and P2-purinoceptor ligands showed a displacement order of Ap4A > adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) > 5'-adenylyl-imidodiphosphate (AMP-PNP) > alpha,beta-methylene adenosine 5'-triphosphate (alpha,beta-..
  64. ncbi ADP-ribosylating bacterial enzymes for the targeted control of mucosal tolerance and immunity
    Nils Lycke
    Department of Clinical Immunology, University of Goteborg, S413 46 Göteborg, Sweden
    Ann N Y Acad Sci 1029:193-208. 2004
    ..The CTA1-DD adjuvant is a fusion protein composed of the ADP-ribosylating part of CT, CTA1, and DD, which is derived from Staphylococcus areus protein A and targets the ..
  65. ncbi Arginyl-glycyl-aspartyl (RGD) epitope of human apolipoprotein (a) inhibits platelet aggregation by antagonizing the IIb subunit of the fibrinogen (GPIIb/IIIa) receptor
    D E Barre
    School of Education, Health and Wellness, Cape Breton University, Sydney, Nova Scotia, Canada
    Thromb Res 119:601-7. 2007
    ..subjects) were prepared from fresh plasma, washed three times in Tyrode's buffer and stimulated using 10 microM ADP or 2 microg/ml collagen...
  66. ncbi Quantitative analysis of cation binding to the adenosine nucleotides using the variable ionic strength method: validation of the Debye-Hückel-Onsager theory of electrophoresis in the absence of counterion binding
    Earle Stellwagen
    Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    Electrophoresis 28:1053-62. 2007
    The free solution mobilities of the adenosine nucleotides 5'-adenosine triphosphate (ATP), 5'-adenosine diphosphate (ADP), 5'-adenosine monophosphate (AMP), and 3'-5'-cyclic AMP (cAMP) have been measured in diethylmalonate buffers ..
  67. ncbi Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin
    T Iiri
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Eur J Biochem 202:635-41. 1991
    ..Gs (guanine-nucleotide-binding proteins involved in adenylate cyclase inhibition and stimulation, respectively) was ADP-ribosylated by cholera toxin in differentiated HL-60 cell membranes upon stimulation of chemotactic receptors by ..
  68. ncbi Activation of the cloned platelet thrombin receptor decreases the pertussis-toxin-dependent ADP-ribosylation of the membrane and soluble inhibitory guanine-nucleotide-binding-alpha proteins. Inhibition by the prostacyclin analog, iloprost
    B Wilhelm
    , , Germany
    Eur J Biochem 216:81-8. 1993
    ..1991) Cell 64, 1057-1068] and to glycoprotein Ib. In the present study, the decrease of pertussis-toxin-dependent ADP-ribosylation of membrane and soluble inhibitory guanine-nucleotide-binding alpha (Gi alpha) proteins was measured ..
  69. doi Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase beta in long patch base excision repair
    Maria Sukhanova
    Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia
    Mutat Res 685:80-9. 2010
    Poly(ADP-ribose)polymerase 1 (PARP1), functioning as DNA nick-sensor, interacts with base excision repair (BER) DNA intermediates containing single-strand breaks...
  70. ncbi [Characteristics of adenine nucleotide translocator in mitochondria of rat cerebral cortex during hypobaric hypoxia exposure.]
    Li Fen Chen
    Department of Pathophysiology, College of High Altitude Military Medicine, The Third Military Medical University, Chongqing 400038, China
    Sheng Li Xue Bao 58:29-33. 2006
    ..Mitochondria was initiated by addition of (3)H-ADP and terminated after 12 s by quick addition of ATR...
  71. ncbi [Regulation of oxidative phosphorylation by liver mitochondria receptors after adaptation by rats to periodic normal pressure and acute hypoxia]
    N M Kurhaliuk
    Ivan Franko Lviv National University, Ukraine
    Ukr Biokhim Zh 74:114-9. 2002
    ..In control rats AH provoked: 1) in the presence of succinate, a 33% augmentation of ADP-stimulated mitochondrial respiration (V3) with a 18% decrease of O2 uptake efficiency (ADP/O ratio); 2) in the ..
  72. ncbi Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin
    Paolo Lova
    Center of Excellence in Applied Biology, Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia
    J Biol Chem 279:25299-306. 2004
    ..able to elicit comparable intracellular Ca(2+) increase and serotonin release was differently dependent on secreted ADP. In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase, activation of Rap1B ..
  73. ncbi Formation of the myosin.ADP.gallium fluoride complex and its solution structure by small-angle synchrotron X-ray scattering
    S Maruta
    Department of Bioengineering, Faculty of Engineering, Soka University, Hachioji, Tokyo, 192 8577, Japan
    J Biochem 125:177-85. 1999
    ..The complex formed quickly, although several times slower than the BeFn complex. The half-life of the myosin.ADP.GaFn complex was about 50 h at 4 degreesC. The formation of the myosin.ADP...
  74. doi Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activity
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Tykistokatu 6A, Turku, 20520 Finland
    Biosci Rep 28:189-94. 2008
    ..were then quantified radiochemically by TLC analysis of the ATP-induced conversion of [(3)H]AMP and [(3)H]ADP into [(3)H]ADP/ATP and [(3)H]ATP respectively...
  75. ncbi The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries
    A A Sauve
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochemistry 37:13239-49. 1998
    Human recombinant CD38 catalyzes the formation of both cyclic ADP-ribose and ADP-ribose products from NAD+ and hydrolyzes cyclic ADP-ribose to ADP-ribose. The corresponding GDP products are formed from NGD+...
  76. ncbi Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation
    Francesca Campus
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia
    J Biol Chem 280:24386-95. 2005
    ..TPO) to the cMpl receptor on human platelets potentiates aggregation induced by a number of agonists, including ADP. In this work, we found that TPO was able to restore ADP-induced platelet aggregation upon blockade of the G(q)-..
  77. ncbi TNP-ATP and TNP-ADP as probes of the nucleotide binding site of CheA, the histidine protein kinase in the chemotaxis signal transduction pathway of Escherichia coli
    R C Stewart
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park 20742, USA
    Biochemistry 37:12269-79. 1998
    ..the fluorescent nucleotide analogues TNP-ATP [2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate] and TNP-ADP. Spectroscopic studies indicated that CheA bound TNP-ATP and TNP-ADP with high affinity (micromolar Kd values) and ..
  78. ncbi Evidence with antiplatelet therapy and ADP-receptor antagonists
    J Donald Easton
    Department of Neurology, Brown University, Providence, RI, USA
    Cerebrovasc Dis 16:20-6. 2003
    ..Clopidogrel and ticlopidine are adenosine diphosphate (ADP)-receptor antagonists that inhibit ADP-induced fibrinogen binding to platelets, a necessary step in the platelet ..
  79. pmc Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
    Richard Graeff
    Department of Physiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:27629-36. 2009
    Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes that catalyze the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a Ca(2+) messenger molecule responsible for regulating a wide range ..
  80. pmc Effects of analogues of adenine nucleotides on increases in intracellular calcium mediated by P2T-purinoceptors on human blood platelets
    D A Hall
    Receptors and Cellular Regulation Research Group, School of Biological Sciences, University of Surrey, Guildford
    Br J Pharmacol 108:728-33. 1993
    ..nucleotides, the structure-activity relationships of the human platelet receptor for adenosine 5'-diphosphate (ADP) mediating increases in intracellular calcium were investigated, and compared with the known structure-activity ..
  81. ncbi CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose
    A De Flora
    Institute of Biochemistry, University of Genova, 16132 Genova, Italy
    J Biol Chem 272:12945-51. 1997
    CD38, a lymphocyte differentiation antigen, is also a bifunctional enzyme catalyzing the synthesis of cyclic ADP-ribose (cADPR) from NAD+ and its hydrolysis to ADP-ribose (ADPR)...
  82. doi Differential activities of cellular and viral macro domain proteins in binding of ADP-ribose metabolites
    Maarit Neuvonen
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Mol Biol 385:212-25. 2009
    ..The functions of the macro domain are poorly understood, but it has been suggested to be an ADP-ribose-binding module...
  83. ncbi Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain
    R N Puri
    Thrombosis Research Center, Philadelphia, Pennsylvania
    Arch Biochem Biophys 271:346-58. 1989
    5'-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change, aggregation and exposure of fibrinogen binding sites concomitant with covalent modification of a single surface ..
  84. ncbi Endogenous ADP-ribosylation for eukaryotic elongation factor 2: evidence of two different sites and reactions
    Muhammet Bektaş
    Istanbul University, Istanbul Faculty of Medicine, Department of Biophysics, 34390 Capa, Istanbul, Turkey
    Cell Biochem Funct 24:369-80. 2006
    Eukaryotic elongation factor 2 can undergo ADP-ribosylation in the absence of diphtheria toxin under the action of an endogenous transferase...
  85. pmc In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)
    Helge Otto
    Institute of Immunology, University Hospital Hamburg Eppendorf, Germany
    BMC Genomics 6:139. 2005
    b>ADP-ribosylation is an enzyme-catalyzed posttranslational protein modification in which mono(ADP-ribosyl)transferases (mARTs) and poly(ADP-ribosyl)transferases (pARTs) transfer the ADP-ribose moiety from NAD onto specific amino acid side ..
  86. ncbi Enhanced increases in cytosolic Ca2+ in ADP-stimulated platelets from patients with delta-storage pool deficiency--a possible indicator of interactions between granule-bound ADP and the membrane ADP receptor
    B Lages
    Department of Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    Thromb Haemost 77:376-82. 1997
    ..In the presence and absence of extracellular calcium, the [Ca2+]i response induced by 10 microM ADP, but not those induced by 0.1 unit/ml thrombin, 3...
  87. ncbi Use of stable analogs of myosin ATPase intermediates for kinetic studies of the "weak" binding of myosin heads to F-actin
    E V Rostkova
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 117071, Russia
    Biochemistry (Mosc) 64:875-82. 1999
    It is known that ternary complexes of myosin subfragment 1 (S1) with ADP and the Pi analogs beryllium fluoride (BeFx) and aluminum fluoride (AlF4-) are stable analogs of the myosin ATPase intermediates M* x ATP and M** x ADP x Pi, ..
  88. pmc Comparison of air displacement plethysmography to hydrostatic weighing for estimating total body density in children
    Geo Claros
    Department of Health and Exercise Science, University of Oklahoma, Norman, OK, USA
    BMC Pediatr 5:37. 2005
    The purpose of this study was to examine the accuracy of total body density and percent body fat (% fat) using air displacement plethysmography (ADP) and hydrostatic weighing (HW) in children.
  89. pmc P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease
    Anneke Bierend
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Br J Clin Pharmacol 65:540-7. 2008
    Genetic polymorphisms of the P2Y(12) ADP receptor on platelets have been shown to contribute to variability in platelet aggregation in healthy humans...
  90. pmc Modulation of the poly(ADP-ribosyl)ation reaction via the Arabidopsis ADP-ribose/NADH pyrophosphohydrolase, AtNUDX7, is involved in the response to oxidative stress
    Kazuya Ishikawa
    Department of Advanced Bioscience, Faculty of Agriculture, Kinki University, Nara 631 8505, Japan
    Plant Physiol 151:741-54. 2009
    Here, we assessed modulation of the poly(ADP-ribosyl)ation (PAR) reaction by an Arabidopsis (Arabidopsis thaliana) ADP-ribose (Rib)/NADH pyrophosphohydrolase, AtNUDX7 (for Arabidopsis Nudix hydrolase 7), in AtNUDX7-overexpressed (Pro(35S)..
  91. ncbi Structural characteristics of the nucleotide-binding site of Escherichia coli primary replicative helicase DnaB protein. Studies with ribose and base-modified fluorescent nucleotide analogs
    W Bujalowski
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch at Galveston 77555 0653
    Biochemistry 33:4682-94. 1994
    ..have been studied, using the base-modified fluorescent nucleotide analog 1, N6-ethenoadenosine diphosphate (epsilon ADP) and the ribose-modified fluorescent analogs 3'(2')-O-(N-methylantraniloyl)adenosine 5'-diphosphate (MANT-ADP), 3'-..
  92. ncbi Direct NAD(P)H hydrolysis into ADP-ribose(P) and nicotinamide induced by reactive oxygen species: a new mechanism of oxygen radical toxicity
    B Tavazzi
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Italy
    Free Radic Res 33:1-12. 2000
    ..extent, the oxidation of NAD(P)H to NAD(P)+, only Fe2+-H2O2 also caused the formation of equimolar amounts of ADP-ribose(P) and nicotinamide...
  93. ncbi Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases
    Louise A Rafty
    Oregon Health and Science University, Department of Biochemistry and Molecular Biology, Portland, Oregon 97201 3098, USA
    J Biol Chem 277:47114-22. 2002
    ..Recent evidence has indicated that these proteins produce a novel metabolite O-acetyl-ADP-ribose (OAADPr) during deacetylation...
  94. ncbi Within- and between-laboratory precision in the measurement of body volume using air displacement plethysmography and its effect on body composition assessment
    A L Collins
    Department of Health Human Sciences, London Metropolitan University, London, UK
    Int J Obes Relat Metab Disord 28:80-90. 2004
    ..of within- and between-laboratory precision in body volume (BV) measurements using air displacement plethysmography (ADP), the BOD POD body composition system, and to interpret any such variability in terms of body composition estimates.
  95. ncbi Bioelectrical impedance vs air displacement plethysmography and dual-energy X-ray absorptiometry to determine body composition in patients with end-stage renal disease
    Paul J Flakoll
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
    JPEN J Parenter Enteral Nutr 28:13-21. 2004
    ..Estimates of body water are fundamental for bioelectrical impedance analysis (BIA), which measures electrical resistance to estimate total body water and body composition...
  96. ncbi Poly(ADP-ribose) glycohydrolase in bovine retained and not retained placenta
    M Kankofer
    Department of Biochemistry, Faculty of Veterinary Medicine, Agricultural University, Lublin, Poland
    Reprod Domest Anim 39:39-42. 2004
    Poly(ADP-ribose) glycohydrolase (PARG) is the enzyme which degrades poly(ADP-ribose) polymers synthesized by poly(ADP-ribose) polymerase (PARP)...
  97. ncbi NAD glycohydrolase activities and ADP-ribose uptake in erythrocytes from normal subjects and cancer patients
    Isil Albeniz
    Istanbul University, Istanbul Faculty of Medicine, Department of Biophysics Capa Istanbul, Turkey
    Biosci Rep 24:41-53. 2004
    ..NAD glycohydrolase activities than control erythrocytes from normal subjects and also similarly increased [14C] ADP-ribose uptake values...
  98. ncbi Protein-protein interaction of the human poly(ADP-ribosyl)transferase depends on the functional state of the enzyme
    J Griesenbeck
    Institut fur Biochemie, Freie Universitat Berlin, Germany
    Biochemistry 36:7297-304. 1997
    Poly(ADP-ribosyl)transferase (pADPRT) is a nuclear protein which catalyzes the polymerization of ADP-ribose using NAD+ as substrate, as well as the transfer of ADP-ribose polymers to itself and other protein acceptors...
  99. ncbi Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells
    Hidemitsu Nakajima
    Pharmaceutical Research Center, Meiji Seika Kaisha Limited, 760 Moro oka cho, Kohoku Ku, Yokohama 222 8567, Japan
    J Biol Chem 279:42774-86. 2004
    Synthesis of ADP-ribose polymers catalyzed by poly-(ADP-ribose) polymerase-1 (PARP-1) has been implicated in transcriptional regulation...
  100. ncbi Carbon monoxide inhibits capacitative calcium entry in human platelets
    Oscar A Gende
    Centro de Investigaciones Cardiovasculares, Catedra de Fisiologia con Biofisica, Facultad de Ciencias Medicas, Universidad Nacional de La Plata 60 y 120, 1900 La Plata, Argentina
    Thromb Res 114:113-9. 2004
    ..solutions, this work examines the changes in [Ca(2+)](i) induced by 100 microM adenosine 5'diphosphate (ADP), 0.1 IU/ ml thrombin, 0.5 microM thapsigargin or 0.5 microM ionomycin in human platelets...
  101. ncbi P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets
    Knut Fälker
    Martin Luther University Halle Wittenberg, Faculty of Medicine, Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, Germany
    Thromb Haemost 93:880-8. 2005
    ..We demonstrate that a set of proteins of 27, 29, 31, 34, and 39 kDa is affected by released ADP and P2Y12 receptor signaling during platelet activation...

Research Grants109 found, 100 shown here

    Sufan Chien; Fiscal Year: 2013
    ..to the body is inadequate for the generation of the adenosine triphosphate (ATP) and adenosine diphosphate (ADP) necessary to maintain the function and structural integrity of tissues...
  2. Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP Synthase
    Zulfiqar Ahmad; Fiscal Year: 2009
    ..plants, and almost all microorganisms in the form of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate (Pi). A typical 70 kg human with relatively sedentary life style will generate around 2...
  3. Role and Mechanism of ATP Hydrolysis in Actin
    Isaiah Sumner; Fiscal Year: 2012
    ..Actin binds to adenosine triphosphate (ATP) and will also catalyze its hydrolysis to adenosine diphosphate (ADP). The rates for this reaction are greatly different for free actin monomers and polymerized actin monomers...
  4. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Phase I resulted in our discovery of low nanomolar level inhibitors of ADP-induced human platelet aggregation, with a unique mechanism of action, that warrant further development as first-in-class ..
  5. IVAN B YANACHKOV; Fiscal Year: 2015
    ..Ap4A) analogs, which inhibit platelet aggregation by a unique new mechanism, targeting both platelet ADP receptors, P2Y1 and P2Y12...
  6. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..interactions between Ca2+ spark and sarcolemmal ion channels;(3) the physiological functions of the cADPR and ADP-ribosyl cyclase;and (4) the functional interactions of RyR- and NAADP-sensitive Ca2+ stores in PASMCs...
  7. Hening Lin; Fiscal Year: 2016
    ..significant impact on other NAD-dependent enzymes, particularly the NAD-dependent deacetylases (sirtuins) and poly(ADP-ribose) polymerases (PARPs)...
  8. Hening Lin; Fiscal Year: 2016
    ..These toxins catalyze the transfer of an adenosine diphosphate ribose (ADP-ribose) from nicotinamide adenine dinucleotide (NAD) to one of the nitrogen atoms in the imidazole ring...
  9. Joshua A Boyce; Fiscal Year: 2016
    ..b>ADP, an abundant extracellular nucleotide, is the natural ligand for P2Y12 and P2Y1 receptors...
  10. Derek C Molliver; Fiscal Year: 2016
    ..sensory neurons conveying pain and is mediated by G protein-coupled receptors (GPCRs) for adenosine diphosphate (ADP)...
  11. Nitric Oxide--Neurotoxic Mechanisms of MPTP
    Allen Mandir; Fiscal Year: 2002
    Poly (ADP-ribose) polymerase (PARP-1), a nuclear enzyme that facilitates DNA repair, may be instrumental in acute neuronal cell death in a variety of insults including cerebral ischemia, MPTP-induced parkinsonism, and CNS trauma...
    Mark Francis; Fiscal Year: 2002
    ..Using NAD as a source, bacterial toxins add adenosine diphosphate ribose (ADP-ribose) to proteins, a process called ADP-ribosylation...
    FREDERICK TOBACK; Fiscal Year: 1993
    ..cells (BSC-1 line) permitted us to identify other growth-stimulating agents such as adenosine diphosphate (ADP)...
  14. Biomedical and Functional Studies of CD39
    AARON JACOB MARCUS; Fiscal Year: 2011
    ..This unresponsiveness is due to endothelial NTPDase1/CD39/ecto-ADPase, which rapidly metabolizes ATP and ADP released from activated platelets. This abolishes aggregation and recruitment...
  15. Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain Function
    Wei Chen; Fiscal Year: 2013
    ..is suitable for measuring and quantitatively imaging the net cerebral metabolic rate of ATP synthesis from Pi and ADP (CMRATP) and this MR measured rate is dominated by the rate of oxidative phosphorylation which directly reflects ..
  16. Role of Beta 3 Integrin in Skeletal Metastasis
    Katherine Weilbaecher; Fiscal Year: 2009
    ..unreadable]3 integrin function is modulated by P2Y12, an ADP receptor, and the target of the anti- platelet drug, clopidogrel (Plavix)...
  17. Cell-Cell Interactions in Thrombosis -Request for Extension of Merit Award
    AARON JACOB MARCUS; Fiscal Year: 2013
    ..This unrespon- siveness is due to endothelial NTPDasel/CD39/ecto-ADPase, which rapidly metabolizes ATP and ADP released from activated platelets. This abolishes aggregation and recruitment...
  18. Ulhas P Naik; Fiscal Year: 2016
    ..Activated platelets recruit more platelets by secreting ADP from their granules and by generation of thromboxane A2...
    GUY C LEBRETON; Fiscal Year: 2013
    ..2. The involvement of ADP-mediated Gi signaling in TPR-induced platelet aggregation...
  20. Fadi T Khasawneh; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): While the involvement of signaling of the ADP P2Y1 and the thromboxane A2 receptors (TPR) in the pathogenesis of thrombotic diseases is well documented, there are no antagonists that are currently ..
  21. Michael R King; Fiscal Year: 2014
    ..of additional receptor: ligand interactions required for platelet activation such as GPVI: collagen, P2Y12:ADP, and PAR1:thrombin...
  22. Jay Rappaport; Fiscal Year: 2015
    ..in CNS, similar to an action of regulatory T cells, express ectonucleotidases CD39 and CD73, which convert ATP and ADP to AMP (via CD39), with further metabolism to adenosine (via CD73), providing a potentially important mechanism ..
  23. Paul F Bray; Fiscal Year: 2016
    ..This approach will allow definition of genes regulating the platelet response to specific agonists (ADP, CRP, collagen, TRAP, U46619, ristocetin, CD9 and epinephrine), as well as genes common to multiple platelet ..
    T Kendall Harden; Fiscal Year: 2012
    ..An antagonist (clopidogrel;Plavix) of the platelet ADP-activated P2Y12 receptor has made an enormous impact in modern therapeutics, and the potential for drugs that ..
  25. Novel Molecules in Calcium Signaling in Platelets
    Wolfgang Bergmeier; Fiscal Year: 2013
    ..Integrin activation in the absence of CD-GEFI required signaling by protein kinase C (PKC) and the Gai-coupled ADP receptor, P2Y12. The P2Y12 receptor is the target of one of the most successful anti-thrombotic drugs, clopidogrel...
  26. Antiplatelet Therapy: Platelet Inhibition, Polymorphisms, and Protein Biomarkers
    Marc S Sabatine; Fiscal Year: 2012
    ..will be quantified using an assay that specifically assesses an intermediate downstream to activation of the P2Y12 ADP receptor (the target of thienopyridines)...
  27. Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Heart
    Ranjan K Dash; Fiscal Year: 2013
    ..g., Ca2+) are governed by a dynamic buffering mechanism due to dynamic binding of the cations with phosphates (ATP, ADP, PI) and substrates (TCA cycle intermediates) during transient respiration, which in turn regulate mito- chondrial ..
  28. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..whereas the better known caspase-dependent cell death is detected in the more peripheral regions where ATP and ADP levels are largely preserved...
  29. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    ..Alcohol induces lesions in the proteins of the electron transport chain, and reduces ATP/ADP translocation and ATP synthesis in the mitochondria...
  30. Nanoelectrode arrays for study of the molecular mechanisms, triggers, and inhibit
    Peter J Burke; Fiscal Year: 2012
    ..by uptake of excessive Ca++;increased oxidative stress;decreased mitochondrial membrane potential, and reduced ADP and ATP. It is generally agreed upon that repression of apoptosis is one of the fundamental steps in tumorigenesis...
  31. Hypothermia, anesthesia and NMR metabolomics in ischemic neonatal brain slices
    Lawrence Litt; Fiscal Year: 2012
    ..Each NMR metabolome will consist of twenty 1H TCA Cycle metabolites and three 31P metabolites (ATP, ADP, and PCr), and be obtained from quantifications with 14.1 Tesla 1H/31P/13C NMR spectroscopy...
  32. Role of The Jak-Stat Pathway in Ischemic Preconditioning
    Yu Ting Xuan; Fiscal Year: 2010
    ..ligation assay, DNA laddering, TUNEL assays, and immunohistochemistry of active caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP)...
  33. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..Sir2, which possesses the NAD- dependent deacetylase and ADP-ribosyltransferase activities, mediates the effect of caloric restriction in yeast, C.elegans and fruit flies...
  34. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..enzyme inhibits platelet activation and limits vascular inflammation by enzymatically hydrolyzing extracellular ADP and ATP...
  35. George R Dubyak; Fiscal Year: 2014
    ..roles of: a) P2X7R splice variants with distinctive channel gating and agonist selectivities;b) ART2 family ecto-ADP-ribosyltransferases that extracellular NAD to covalently modify and activate P2X7R;c) coactivated G protein-coupled ..
  36. The Hig1 protein family and the cytochrome c oxidase complex
    Rosemary A Stuart; Fiscal Year: 2012
    ..proteins is found in association with a nonCOX complex, and in a manner, which is influenced by the activity of the ADP/ATP carrier proteins...
  37. Mechanisms and Modulation of Cell Death in Traumatic Brain Injury
    ALAN IRA FADEN; Fiscal Year: 2012
    ..Moreover, AIF translocation can occur under low energetic conditions, in association with activation of poly-ADP-ribose polymerase I (PARP-1) and reduction of nicotinamide adenine dinucleotide (NAD+)...
    Shey Shing Sheu; Fiscal Year: 2010
    ..mitochondrial Ca2+- mediated functions are achieved physiologically by a concomitant increase in mitochondrial ADP, serving not only as a substrate for ATP production but also an inhibitor for mitochondrial permeability transition ..
  39. RAYMOND CHARLES KOEHLER; Fiscal Year: 2014
    ..Poly(ADP-ribose) polymerase-1 (PARP-1) is pivotal in glutamate neurotoxicity and cerebral infarction...
  40. John Varga; Fiscal Year: 2014
    ..We found that the inhibitory effects are mediated through adiponectin (ADP), an adipokine with pleiotropic humoral and paracrine effects produced primarily but not exclusively by fat cells...
  41. Glycolysis and Glutamate Storage into Synaptic Vesicles
    Tetsufumi Ueda; Fiscal Year: 2010
    ..To achieve aim 1, we will study phosphoenol pyruvate plus ADP-dependent uptake in a number of respects, using isolated rat brain synaptic vesicles...
  42. ADP: A Master Regulator for Bioenergetics and Ca2+/ROS Signaling in Heart
    Shey Shing Sheu; Fiscal Year: 2012
    ..b>ADP is the key substrate for ATP formation...
  43. STEVEN MICHAEL CLAYPOOL; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The ADP/ATP carrier/Adenine nucleotide translocase (yeast AAC = mammalian ANT) mediates the 1:1 exchange of ADP into and ATP out of the mitochondrial matrix and is thus required for oxidative ..
  44. Xin Jie Chen; Fiscal Year: 2014
    ..Ant is normally involved in ADP/ATP exchange across the mitochondrial inner membrane...
  45. Regulation of the early events of platelet activation
    Lawrence F Brass; Fiscal Year: 2013
    ..proposal is on the events of platelet activation that occur immediately downstream of agonists such as thrombin, ADP and TxA2, all of whose receptors are coupled to heterotrimeric G proteins...
  46. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ..Fourth, we will characterize the role of mitochondrial DMA depletion and nuclear DMA fragmentation and poly(ADP-ribose)polymerase (PARP) activation for AAP-induced cell death and regeneration...
  47. Purinergic Thromboregulation
    Simon C Robson; Fiscal Year: 2010
    Extracellular nucleotides (ATP, ADP and UTP) are known to activate type-2 purinergic (P2Y and P2X) receptors on platelets, endothelium and immune cells to induce vascular inflammation and thrombosis...
  48. The Role of Sulfonylurea Receptor 2 Splice Variants in Myocardial Function
    John P Fahrenbach; Fiscal Year: 2011
    ..The sulfonylurea receptor 2 (SUR2) is the regulatory subunit of cardiac KATP channel and directly binds to ADP. Therefore, the energy state of the cell determines channel opening...
    JOSE BOYER; Fiscal Year: 2004
    ..the first recognized physiological roles of extracellular nucleotides was the aggregation of platelets induced by ADP. Adenine nucleotide effects of platelet function result from the activation of at least three different receptor ..
  50. Rational Design of NRTI for Drug Resistant HIV-1
    John W Mellors; Fiscal Year: 2010
    ..pharmacology, toxicity, and resistance selection to identify the most promising clinical candidates from the ADP class. This will be accomplished through three Specific Aims...
  51. Molecular Mechanisms of Active Transport Across Cellular Membranes
    Emad Tajkhorshid; Fiscal Year: 2013
    ..use the ionic gradient across the membrane as the source of energy for their function;and (3) the mitochondrial ADP/ATP carrier (AAC) which relies on the membrane potential for exchange of nucleotides betwee the cytoplasm and the ..
  52. Ahmed Bettaieb; Fiscal Year: 2014
    ..M2 (PKM2) is primarily a tetrameric enzyme that catalyzes the transfer of a phosphate from phosphoenolpyruvate to ADP, resulting in pyruvate and ATP...
  53. Thromboregulation in Occlusive Vascular Diseases
    AARON JACOB MARCUS; Fiscal Year: 2012
    ..This occurs via metabolic deletion of prothrombotic ADP, the final common mediator in platelet-induced vascular occlusion...
  54. Anil K Sood; Fiscal Year: 2016
    ..Our hypothesis is that there is a feedback loop between platelets and cancer cells. Cancer cells secrete ADP and activate platelets, and platelets secrete TGF[unreadable]1 that promotes proliferation in cancer cells...
    Ivan Rayment; Fiscal Year: 2013
    ..acetyl groups from acetylated lysine in proteins to the ribose of NAD+, which is cleaved into 2'-acetyl-ADP-ribose and nicotinamide...
  56. Myosin Isoforms in Relation to Function in Human Heart
    Richard L Moss; Fiscal Year: 2010
    ..and then assessing the effects of these mutations on the kinetics of contraction, nucleotide turnover, and ADP release;(2) effects on kinetics due to interactions between the loop and IMD will be assessed by reversing ..
  57. The structure and function of pyruvate carboxylase
    Ivan Rayment; Fiscal Year: 2012
    ..A small amount of this solution will be mixed in a stopped flow apparatus with enzyme, Mg2+, ADP and buffer and the resulting mixture analyzed for ATP formation with a firefly luciferase assay...
  58. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..demonstrated activated MMP-2 within the cardiomyocyte that cleaved myofibrils (4-6) and nuclear matrix protein poly ADP-ribose polymerase (PARP)-a DNA repair enzyme in cell survival during I/R (7)...
  59. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..species that in turn induce DNA single strand breakage and triggering of the nuclear DNA repair enzyme, poly(ADP-ribose) polymerase-1 (PARP-1)...
  60. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..When this genomic injury is then recognized by the nuclear DNA repair enzyme poly (ADP-ribose) polymerase ("PARP"), NAD is cleaved to generate the product poly(ADP-ribose)...
  61. RAJESH K ANEJA; Fiscal Year: 2016
    ..Another nuclear protein, which is activated in similar inflammatory conditions, is Poly (ADP-ribose) Polymerase-1(PARP-1)...
  62. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..R-503 is both 1) a potent inhibitor of the nuclear DNA repair enzyme poly(ADP-ribose) polymeras ("PARP") (IC50=20 nM), and 2) a dihydrolipoate ("DHL")-based redox catalyst that is a superoxide ..
  63. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..When this genomic injury is then recognized by the nuclear DNA repair enzyme poly(ADP-ribose) polymerase ("PARP"), NAD is cleaved to generate the product poly(ADP-ribose)...
  64. Claire Larmonier; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Poly (ADP-ribose) polymerases (PARPs) constitute a family of 18 cell signaling enzymes, which are involved in the regulation of DNA-binding proteins and DNA repair...
  65. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..infiltration (myeloperoxidase), apoptosis (TUNEL staining), 3-nitrotyrosine (a measure of ONOO- formation), poly(ADP-ribose) (a measure of PARP activity);and 2) Improved renal function, reflected by the concentration of urinary ..
  66. NAD Metabolism and Signaling
    Frances E Lund; Fiscal Year: 2011
    ..lysine and generate putative signaling metabolites (sirtuins), that post-translationally modify protein targets by ADP-ribosylation via poly ADP ribose polymerases (PARPs) and mono ADP ribosyltransferases (ARTs) and that regulate cell ..
  67. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    ..NO dysregulation can lead to reactive nitrogen species, leading to cellular protein oxidation and DNA damage. Poly(ADP-ribose) polymerase (PARP) is up-regulated in response to these changes and can lead to cellular depletion of NAD+ ..
  68. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..a measure of lipid peroxidation), histology, and immunohistochemical reactivity to 3-nitrotyrosine (3-NT) and poly(ADP-ribose)...
  69. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..lipid peroxidation (malondialdehyde), glutathione (GSH/GSSG ratio), peroxynitrite formation (3-nitrotyrosine), poly(ADP-ribose) formation, fibrosis (Mason Trichrome staining for collagen), R- 801 levels, and the protein expression of ..
  70. Y S Prakash; Fiscal Year: 2016
    ..specific mechanisms that may be regulated by BDNF: the second messengers IP3 (via phospholipase C PLC) and cyclic ADP ribose (via CD38) (Aim 1);SR Ca2+ release (IP3 receptor vs...
  71. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
    ..Hence there is a critical need for effective and affordable non-surgical therapy for AP. Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme, plays an important role in the pathogenesis of AP...
  72. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..malondialdehyde), reduced and oxidized glutathione (GSH, GSSG), peroxynitrite formation (3-nitrotyrosine), poly(ADP-ribose) formation, fibrosis (Mason Trichrome staining for collagen), R-908 and R-901 levels, and pro-inflammatory ..
  73. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..It has been established that inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) are useful neuroprotective agents especially when the neurodegeneration is caused by ..
  74. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..peroxynitrite via broad-spectrum redox catalysis, and 2) competitively inhibits the nuclear DNA repair enzyme poly(ADP-ribose) polymerase 1 ("PARP- 1")...
  75. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..These oxidizing and nitrosating species induce DNA single strand breaks that activate poly(ADP-ribose) polymerase (PARP), a nuclear DNA repair enzyme that in turn depletes its substrate NAD, resulting in an ..
  76. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..F21-isoprostane, GSH:GSSG ratio), neutrophil infiltration, 3- nitrotyrosine (3-NT), nitrite/nitrate, and poly(ADP-ribose) formation, BUN, creatinine, NGAL, AST, ALT, histology injury score, and serum concentrations of TNF-1, HMGB-..
  77. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..and arginine methylation;lysine acetylation;DNA cytosine methylation;and histone sumoylation, ubiquitination, ADP-ribosylation and phosphorylation...
  78. Robert W Sobol; Fiscal Year: 2014
    ..We posit that Polss inhibition or BER failure signals via poly(ADP)ribose (PAR) synthesis and NAD+/ATP depletion by a process that requires activation of PARP1 &PARP2 and is ..
  79. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2013
    ..Of the three known Ca2+ mobilization second messengers, inositol 1,4,5-trisphosphate (IP3), cyclic ADP- ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP), NAADP is least characterized...
  80. ERICA LYNN CAIN; Fiscal Year: 2014
    ..A clear example of the evolution of drug resistance in a cancer population is resistance to Poly ADP-Ribose Polymerase (PARP) inhibitors (PARPi) in BRCA2-deficient cancers...
  81. Gen Sheng Wu; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): An extensive literature documents the role of poly(ADP-ribose)polymerase 1 (PARP1) in DNA repair. PARP1 recognizes and is activated by single strand DNA breaks...
  82. The role of a novel AIF-associated nuclease PAAN1 in neuronal injury
    Yingfei Wang; Fiscal Year: 2013
    ..Poly(ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in glutamate neurotoxicity and cerebral infarction, which is a ..
  83. Lily Yang; Fiscal Year: 2015
    ..These nanoparticles will carry DNA damaging drugs without or with a poly ADP ribose polymerase (PARP) inhibitor for treatment of TNBC, MRI monitoring of drug delivery and response, and optical ..
  84. Jingwen Liu; Fiscal Year: 2016
    ..oligonucleotide probe) with high resolution mass spectrometry, we have identified the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) as a novel HNF1? interacting protein, implicating its potential role in the ..
  85. John J Turchi; Fiscal Year: 2016
    ..in breast and ovarian cancer (4;5) and the common alteration of HR in these cancers has led to targeting poly-ADP-ribose polymerase (PARP) by exploiting the concept of synthetic lethality...
  86. Rahul Nene; Fiscal Year: 2015
    ..The success of poly(ADP-ribose) polymerase (PARP) inhibitors against cancers with defects in the BRCA1 and BRCA2 genes demonstrates that a ..
  87. Imaging cellular energy metabolism in brain slices using fluorescent biosensors
    REBECCA ANNE MONGEON; Fiscal Year: 2013
    ..Recently developed genetically-encoded fluorescent biosensors that report the ATP/ADP ratio and the NADH/NAD+ ratio provide the ability to perform live imaging of energy metabolism in individual brain ..
  88. Scott H Kaufmann; Fiscal Year: 2016
    ..Project 1, "Poisoning of PARP and topoisomerase I to treat ovarian cancer," studies the effect of the poly(ADP-ribose) polymerase (PARP) inhibitor ABT-888 alone and In combination with topotecan...
  89. GARRY JOHN SOUTHAN; Fiscal Year: 2014
    ..targets and have proven effective in a broad range of acute lung injuries: 1) R-503, a bifunctional poly (ADP-ribose) polymerase ("PARP") inhibitor- lipoic acid conjugate;2) R-100, a bifunctional organic nitrate and ..
  90. Gabriel Mbalaviele; Fiscal Year: 2016
    ..Indeed, this inflammasome is also involved in the cleavage of poly(ADP-ribose) polymerase 1 (PARP1), a novel mechanism of NF-?B co- activation, and osteoclast (OC) development...
  91. Andrew Zhuang Wang; Fiscal Year: 2016
    ..The third aim will study NP formulations of poly ADP ribose polymerase inhibitors (PARPIs)'s potential in chemoradiotherapy...
  92. Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death
    KAREN DAVID; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death Poly (ADP-ribose) polymerase-1 (PARP-1) maintains cell function by facilitating DNA repair...
  93. JASPER D RINE; Fiscal Year: 2016
    ..Sir2, the founding member of the sirtuin family of deacetylases, with respect to the potential role of 2-O-acetyl-ADP-ribose in silencing. The mechanism(s) operating to repress gene expression in silenced chromatin are not yet known...
  94. Omer Yilmaz; Fiscal Year: 2014
    ..in Paneth cells of bone stromal antigen 1 (Bst-1), an ectoenzyme that produces the paracrine factor cyclic ADP ribose (cADPR)...
  95. Daitoku Sakamuro; Fiscal Year: 2015
    ..human cancer cells to cisplatin is dependent on the expression of Bin1, a protein that inhibits c-Myc-induced poly(ADP-ribose) polymerase-1 (or PARP-1) activity...
  96. GARY I YELLEN; Fiscal Year: 2016
    ..We will record the ope probability of KATP channels simultaneously with biosensor measurements of [ATP] or ATP:ADP ratio, to learn the actual dose--response relation for intact neurons, and the conditions for engaging these ..
  97. James L Keck; Fiscal Year: 2014
    ..Recently chemotherapeutics that block activity of the DNA repair protein poly ADP ribose polymerase have shown great promise as more selective genomic destabilization agents...
  98. Sanford I Bernstein; Fiscal Year: 2016
    ..the hypothesis that distal arthrogryposis mutations cause abnormal interactions with nucleotides yielding enhanced ADP binding, reduced sliding velocity, slowed relaxation dynamics and hypercontraction and that the severity of the ..
  99. Vern L Schramm; Fiscal Year: 2016
    ..The first aim is o target an esterase responsible for degrading a product of the sirtuin pathways, 2'-O-acetyl-ADP-ribose. This unstable ester has the chemical characteristics of a down-stream signal-transducing molecule...
    Jon Mabley; Fiscal Year: 2000
    ..triggered by hydrogen peroxide and peroxynitrite is recognized by a specific domain of the nuclear enzyme poly (ADP-ribose) synthetase (PARS)...
    Pin Lan Li; Fiscal Year: 2000
    ..Recently, several important observations suggest that intracellular ADP-riboses may serve as a new second messenger to regulate cell functions in non-vascular tissues...