vitamin D binding protein

Summary

Gene Symbol: vitamin D binding protein
Description: GC, vitamin D binding protein
Alias: DBP, DBP/GC, GRD3, Gc-MAF, GcMAF, HEL-S-51, VDBG, VDBP, vitamin D-binding protein, DBP-maf, VDB, epididymis secretory protein Li 51, gc protein-derived macrophage activating factor, gc-globulin, group-specific component (vitamin D binding protein), vitamin D-binding alpha-globulin, vitamin D-binding protein-macrophage activating factor
Species: human

Top Publications

  1. ncbi The relationship between concentrations of vitamin D-binding protein (DBP) in serum and colostrum of mares and in serum of their foals in the neonatal period
    J P Madej
    Department of Veterinary Prevention and Immunology, Department and Clinic of Obstetrics, Ruminant Diseases and Animal Health Care, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Norwida 31, 50 375 Wrocław, Poland
    Pol J Vet Sci 12:499-507. 2009
  2. ncbi Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease
    L H Shen
    Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    J Int Med Res 38:1093-8. 2010
  3. pmc Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3
    Anisha B Shah
    Department of Pathology, Health Sciences Center, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    Mol Immunol 43:1109-15. 2006
  4. pmc Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity
    T A McNearney
    Howard Hughes Medical Institute Laboratories, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 166:1525-35. 1987
  5. ncbi Localization and quantitation of the vitamin D binding protein (Gc-globulin) in human neutrophils
    R R Kew
    Department of Pathology, State University of New York, Stony Brook 11794 8691
    Blood 82:274-83. 1993
  6. pmc Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system
    Ludovic R Otterbein
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Proc Natl Acad Sci U S A 99:8003-8. 2002
  7. ncbi [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease]
    Ming Lu
    Department of Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Nei Ke Za Zhi 43:117-20. 2004
  8. ncbi Gc globulin (vitamin D-binding protein) levels: an inhibition ELISA assay for determination of the total concentration of Gc globulin in plasma and serum
    C S Jørgensen
    Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark
    Scand J Clin Lab Invest 64:157-66. 2004
  9. ncbi Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk
    La Creis R Kidd
    Department of Pharmacology and Toxicology, Cancer Prevention and Control Program, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky
    Prostate 64:272-82. 2005
  10. doi The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1339-43. 2008

Detail Information

Publications316 found, 100 shown here

  1. ncbi The relationship between concentrations of vitamin D-binding protein (DBP) in serum and colostrum of mares and in serum of their foals in the neonatal period
    J P Madej
    Department of Veterinary Prevention and Immunology, Department and Clinic of Obstetrics, Ruminant Diseases and Animal Health Care, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Norwida 31, 50 375 Wrocław, Poland
    Pol J Vet Sci 12:499-507. 2009
    Vitamin D-binding protein (DBP) participates in the actin scavenger system, it is a carrier of vitamin D and its derivatives, it manifests the capacity to bind mainly monounsaturated and saturated fatty acids, it binds to the surface of ..
  2. ncbi Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease
    L H Shen
    Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    J Int Med Res 38:1093-8. 2010
    ..Genetic polymorphism of the vitamin-D-binding protein (VDBP) gene is considered one of the candidates for variation in susceptibility to COPD...
  3. pmc Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3
    Anisha B Shah
    Department of Pathology, Health Sciences Center, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    Mol Immunol 43:1109-15. 2006
    The Vitamin D binding protein (DBP) is a multifunctional plasma protein that can significantly enhance the chemotactic response to complement fragment C5a...
  4. pmc Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity
    T A McNearney
    Howard Hughes Medical Institute Laboratories, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 166:1525-35. 1987
    ..These results indicate that the genetically and structurally related gC-1 and gC-2 share the functional activity of binding to human C3 and enhance viral infectivity...
  5. ncbi Localization and quantitation of the vitamin D binding protein (Gc-globulin) in human neutrophils
    R R Kew
    Department of Pathology, State University of New York, Stony Brook 11794 8691
    Blood 82:274-83. 1993
    Plasma-derived vitamin D binding protein (DBP) is an important physiologic regulator of the neutrophil chemotactic response to activated complement. A cell-associated form of DBP has been observed in numerous cell types...
  6. pmc Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system
    Ludovic R Otterbein
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Proc Natl Acad Sci U S A 99:8003-8. 2002
    ..In the second phase, the vitamin D-binding protein (DBP) traps the actin monomers, which accelerates their clearance...
  7. ncbi [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease]
    Ming Lu
    Department of Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Nei Ke Za Zhi 43:117-20. 2004
    To determine the association between vitamin D binding protein (VDBP) gene and chronic obstructive pulmonary disease (COPD) susceptibility in Han Nationality in China.
  8. ncbi Gc globulin (vitamin D-binding protein) levels: an inhibition ELISA assay for determination of the total concentration of Gc globulin in plasma and serum
    C S Jørgensen
    Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark
    Scand J Clin Lab Invest 64:157-66. 2004
    b>Gc globulin, also called vitamin D-binding protein, is a plasma protein involved in the actin-scavenger system...
  9. ncbi Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk
    La Creis R Kidd
    Department of Pharmacology and Toxicology, Cancer Prevention and Control Program, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky
    Prostate 64:272-82. 2005
    The vitamin D receptor (VDR) and binding protein (DBP) mediate the cellular transport, activity, and anti-tumor action of 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D3]...
  10. doi The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1339-43. 2008
    ..The association between polymorphisms in the vitamin D binding protein (Gc) and postmenopausal breast cancer risk, with additional focus on the influence of serum 25-..
  11. doi Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation
    Lei Fu
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L5
    Clin Biochem 42:1174-7. 2009
    To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year.
  12. doi A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
    John J McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Locked Bag 500, Richlands Q4077, Australia
    J Steroid Biochem Mol Biol 121:471-7. 2010
    ..We found nine studies related to the vitamin D binding protein (group-specific component, GC), and five studies examining the vitamin D receptor (VDR)...
  13. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  14. doi Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    J Steroid Biochem Mol Biol 127:405-12. 2011
    Variants of the vitamin D binding protein (VDBP) gene appear to be associated with levels of the main circulating vitamin D metabolite, 25-hydroxyvitamin D [(25(OH)D]...
  15. pmc Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia
    Elizabeth A Hibler
    Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 21:368-75. 2012
    ..This study evaluated associations between polymorphic variation in the Gc-globulin (GC) and calcium-sensing receptor (CASR) and odds for metachronous colorectal neoplasia and vitamin D metabolite concentrations...
  16. pmc Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling
    Rene F Chun
    UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and Orthopaedic Hospital Research Center, Los Angeles, California, United States of America
    PLoS ONE 7:e30773. 2012
    b>Vitamin D binding protein (DBP) plays a key role in the bioavailability of active 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and its precursor 25-hydroxyvitamin D (25OHD), but accurate analysis of DBP-bound and free 25OHD and 1,25(OH)(2)D is ..
  17. pmc Circulating 25-hydroxyvitamin D, vitamin D-binding protein and risk of prostate cancer
    Stephanie J Weinstein
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20982 7242, USA
    Int J Cancer 132:2940-7. 2013
    ..To further elucidate this association, we examined the influence of vitamin D-binding protein (DBP), the primary transporter of vitamin D compounds in the circulation...
  18. ncbi Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism
    N E Cooke
    Hum Genet 73:225-9. 1986
    Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4...
  19. ncbi Sequence and organization of the human vitamin D-binding protein gene
    A Braun
    Institute of Anthropology and Human Genetics, University of Munich, Germany
    Biochim Biophys Acta 1216:385-94. 1993
    The structure and organization of the human vitamin D-binding protein (DBP) gene has been determined. The gene is composed of 13 exons and 12 intervening sequences...
  20. ncbi Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis
    T Ishii
    Dept of Geriatric Medicine, University of Tokyo, Japan
    Eur Respir J 18:753-7. 2001
    ..However, no association between this polymorphism of Gc-globulin and susceptibility to diffuse panbronchiolitis was found...
  21. ncbi A structural basis for the unique binding features of the human vitamin D-binding protein
    Christel Verboven
    Laboratorium voor Analytische Chemie en Medicinale Fysicochemie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, E Van Evenstraat 4, B 3000 Leuven, Belgium
    Nat Struct Biol 9:131-6. 2002
    The human serum vitamin D-binding protein (DBP) has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune ..
  22. ncbi A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis
    Michael A Pani
    Department of Internal Medicine I, University Hospital Frankfurt am Main, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    J Clin Endocrinol Metab 87:2564-7. 2002
    ..The polymorphic vitamin D-binding protein (DBP) greatly facilitates vitamin D actions, and DBP alleles differ regarding their affinity for 1,25(OH)(2) D(3)...
  23. pmc Lack of association of group specific component haplotypes with lung function in smokers
    I Kasuga
    University of British Columbia, McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Thorax 58:790-3. 2003
    ..Several reports have described associations between GC haplotypes and COPD but these remain controversial. In addition, most of these studies were based on a small number of subjects...
  24. ncbi Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral density
    Yoichi Ezura
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
    J Bone Miner Res 18:1642-9. 2003
    Possible contribution of vitamin D-binding protein (DBP) gene for determination of BMD was tested by characterizing 13 SNPs in 384 adult Japanese women...
  25. ncbi Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland
    Jürgen Laufs
    deCODE Genetics, Sturlugata 8, Reykjavik 101, Iceland
    Am J Pharmacogenomics 4:63-8. 2004
    Previous studies of vitamin D binding protein (VDBP, also known as group-specific component, Gc, encoded by the GC gene) have implicated two gene variants, GC*2 and GC*1F, as possible contributors with chronic obstructive pulmonary ..
  26. ncbi Identification of a region in the vitamin D-binding protein that mediates its C5a chemotactic cofactor function
    Jianhua Zhang
    Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    J Biol Chem 279:53282-7. 2004
    The vitamin D-binding protein (DBP), also known as group-specific component or Gc-globulin, is a multifunctional plasma protein that can significantly enhance the leukocyte chemotactic activity to C5a and C5a des-Arg...
  27. ncbi Vitamin D
    Adriana S Dusso
    Renal Division, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Physiol Renal Physiol 289:F8-28. 2005
    ..This local production of 1,25(OH)(2)D(3) is dependent on circulating precursor levels, providing a potential explanation for the association of vitamin D deficiency with various cancers and autoimmune diseases...
  28. pmc Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway
    Matthias Wjst
    Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg Munich, Germany
    Respir Res 7:60. 2006
    ....
  29. ncbi Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men
    Z H Al-oanzi
    School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Osteoporos Int 19:951-60. 2008
    ..We confirm the results of an earlier study in a different cohort, showing relationship between certain genotypes of (TAAAn)-Alu repeats and reduced BMD and vertebral fractures...
  30. doi Population studies of Vitamin D Binding Protein microheterogeneity by mass spectrometry lead to characterization of its genotype-dependent O-glycosylation patterns
    Chad R Borges
    Molecular Biosignatures Analysis Unit, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA
    J Proteome Res 7:4143-53. 2008
    ..the genotype-dependent glycosylation patterns for each of the three major allele products of Vitamin D Binding Protein found in the general human population...
  31. doi Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women
    Marc Sinotte
    Departement de Medecine sociale et preventive, Universite Laval, Quebec, Canada
    Am J Clin Nutr 89:634-40. 2009
    ..b>Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide ..
  32. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  33. pmc Genome-wide association study of circulating vitamin D levels
    Jiyoung Ahn
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    Hum Mol Genet 19:2739-45. 2010
    ..8x10(-49)), NADSYN1/DHCR7 (P=3.4x10(-9)) and CYP2R1 (P=2.9x10(-17)), but not C10orf88 (P=2.4x10(-5))...
  34. doi Candidate genes for COPD in two large data sets
    P S Bakke
    Dept of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
    Eur Respir J 37:255-63. 2011
    ..05). This study has replicated associations to COPD phenotypes in the STAT1, NFKBIB/SIRT2 and GC genes in two independent populations, the associations of the former two genes representing novel findings...
  35. doi Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects
    Feng Xiao Bu
    Osteoporosis Research Center, Creighton University Medical Center, Creighton University, 601 N 30th St, Suite 6730, Omaha, NE 68131, USA
    Hum Genet 128:549-56. 2010
    ..was observed at SNPs in the CYP2R1 (cytochrome P450, family 2, subfamily R, polypeptide 1) and the GC (vitamin D binding protein) gene...
  36. doi The emerging role of vitamin D binding protein in multiple sclerosis
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    J Neurol 258:353-8. 2011
    ..A growing body of evidence supports a role for vitamin D in MS aetiology. Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been ..
  37. pmc Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship
    Camille E Powe
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Bone Miner Res 26:1609-16. 2011
    ..Vitamin D-binding protein (DBP), the major carrier protein for 25(OH)D, may alter the biologic activity of circulating vitamin D...
  38. pmc Impact of circulating vitamin D binding protein levels on the association between 25-hydroxyvitamin D and pancreatic cancer risk: a nested case-control study
    Stephanie J Weinstein
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20982, USA
    Cancer Res 72:1190-8. 2012
    ..is contrary to an expected inverse association between vitamin D status and cancer, we examined whether vitamin D binding protein (DBP), the primary carrier of vitamin D compounds in circulation, plays a role in this relationship...
  39. doi The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children
    Yuling Zhang
    Department of Pediatrics, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, PR China
    Swiss Med Wkly 142:w13636. 2012
    ..This population-based study was the first to confirm the strong effects of the GC, CYP2R1 and DHCR7/NADSYN1 loci on circulating 25(OH)D concentrations in northeastern Han Chinese children...
  40. doi Association of vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients
    Don Vu
    Mendez National Institute of Transplantation, Los Angeles, CA, USA
    Mol Biol Rep 40:933-9. 2013
    Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant ..
  41. pmc Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms
    Linda Larcombe
    Faculty of Medicine, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 7:e49872. 2012
    ..Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic diseases...
  42. pmc Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family
    N E Cooke
    J Clin Invest 76:2420-4. 1985
    ..Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family.
  43. pmc Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)
    A Nykjaer
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 98:13895-900. 2001
    ..This observation identifies spontaneous mutations in an endocytic receptor pathway affecting cellular uptake and metabolism of a steroid hormone...
  44. ncbi Risk and severity of COPD is associated with the group-specific component of serum globulin 1F allele
    Isao Ito
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Chest 125:63-70. 2004
    ..However, the role of Gc-globulin polymorphism in the development of COPD remains inconclusive...
  45. pmc Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, 1007A WARF, Madison, Wisconsin 53726 2397, USA
    J Clin Endocrinol Metab 93:3381-8. 2008
    ..Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites...
  46. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
    ..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...
  47. doi The glycosylation and characterization of the candidate Gc macrophage activating factor
    Tina Ravnsborg
    Institute of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    Biochim Biophys Acta 1804:909-17. 2010
    The vitamin D binding protein, Gc globulin, has in recent years received some attention for its role as precursor for the extremely potent macrophage activating factor (GcMAF)...
  48. pmc Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:525-36. 2010
    ..Overall, our results do not provide evidence for a role of common genetic variants in VDR or GC in susceptibility to CRC...
  49. ncbi Mapping and conservation of the group-specific component gene in mouse
    F Yang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284
    Genomics 7:509-16. 1990
    ..The mouse GC gene was mapped to chromosome 5, where the ALB and AFP genes are also located, demonstrating conservation of the three genes in vertebrate species...
  50. pmc Human group-specific component (Gc) is a member of the albumin family
    F Yang
    Proc Natl Acad Sci U S A 82:7994-8. 1985
    ..Gc cDNA was used as a probe in Southern blot analysis of somatic-cell hybrids to confirm that the Gc locus is on chromosome 4...
  51. ncbi Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family
    W F Witke
    Department of Biochemistry, University of California, Riverside 92521
    Genomics 16:751-4. 1993
    ..Although the mRNA and protein expressed from the Gc gene are significantly smaller, the gene itself is about 2.5 times larger than the other genes of the family.(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. ncbi Ethnic differences in red blood cell sodium/lithium countertransport and metabolic correlates of hypertension: an international collaborative study
    E Ragone
    Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Italy
    Am J Hypertens 11:935-41. 1998
    ..NT) individuals selected by age (35-60 years), body mass index (BMI; < 30 kg/m2), and blood pressure (BP; HPT, DBP > or = 95 mm Hg; NT, DBP < 90 mm Hg)...
  53. doi Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Clin Chim Acta 390:28-37. 2008
    Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation...
  54. ncbi [Prevalence of hypertension in a black African diabetic population]
    M Ducorps
    Service d'Endocrinologie, ,
    Arch Mal Coeur Vaiss 89:1069-73. 1996
    ..criteria were used to define hypertension (systolic blood pressure (SBP) > or = 140 or diastolic blood pressure (DBP) > or = 90 mmHg...
  55. ncbi Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women
    A L Lauridsen
    Department of Clinical Biochemistry, NBG, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 77:15-22. 2005
    ..in the circulation is the multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, vitamin D-binding protein, or DBP...
  56. ncbi Regression of left ventricular hypertrophy by AT1 receptor blockade in renal transplant recipients
    A U Klingbeil
    Department of Medicine IV and Nephrology, , Germany
    Am J Hypertens 13:1295-300. 2000
    ..5 +/- 2.4 mm Hg and diastolic blood pressure (DBP) by 4.5 +/- 1.8 mm Hg (P < .01 and P < .05, respectively)...
  57. ncbi The impact of birth weight and gestational age on blood pressure in adult life: a population-based study of 49-year-old men
    A Siewert-Delle
    Department of Nephrology, Sahlgrenska University Hospital, , Sweden
    Am J Hypertens 11:946-53. 1998
    ..46, P = .001 and for diastolic blood pressure [DBP], r = -0.44, P = .01; n = 44), and these correlations were independent of birth weight...
  58. pmc First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia
    Camille E Powe
    Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 56:758-63. 2010
    ..Circulating vitamin D is almost entirely bound to vitamin D binding protein, which increases 2-fold during pregnancy and previous studies have not examined vitamin D binding ..
  59. ncbi [Short and long-term clinical tolerance of hypertensive treatment during the HOT study (Hypertension Optimal Treatment)]
    J M Mallion
    , Centre Hospitalier Universitaire de Grenoble
    Arch Mal Coeur Vaiss 89:1093-6. 1996
    ..Defined by randomization, the level to obtain is DBP < or = 80, 85, 90 mmHg...
  60. pmc Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein
    F F Safadi
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6144, USA
    J Clin Invest 103:239-51. 1999
    A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D metabolism and action...
  61. ncbi The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Kommunehospital, Arhus University Hospital, 8000 Arhus C, Denmark
    Eur J Endocrinol 150:355-62. 2004
    ..GH or hormone replacement therapy (HRT) in Turner syndrome (TS) influence the serum concentrations of MBL and two other proteins partaking in the innate immune defence, surfactant protein D (SP-D) and vitamin D binding protein (DBP).
  62. ncbi Hypertension in primary hyperparathyroidism--reduction of blood pressure by long-term treatment with vitamin D (alphacalcidol). A double-blind, placebo-controlled study
    L Lind
    Department of Internal Medicine, , Uppsala, Sweden
    Am J Hypertens 1:397-402. 1988
    ..33 persons with probable primary HPT and mild hypercalcemia detected in a health survey, diastolic blood pressure (DBP) was significantly higher than among age- and sex-matched, normocalcemic, controls (89.4 +/- 9.8 (SD) v 85.2 +/- 8...
  63. ncbi Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin
    Hans Georg Mannherz
    Department of Anatomy and Embryology Ruhr University, Bochum, Germany
    J Mol Biol 366:745-55. 2007
    ..deoxyribonuclease I (DNase I), gelsolin segment 1 (G1), thymosin beta4 (Tbeta4), and vitamin D-binding protein (DbP). To reduce ADF/cofilin induced actin oligomerisation we used ADP-ribosylated actin...
  64. ncbi Blood pressure, catecholamines, and pancreatic polypeptide in obstructive sleep apnea with and without nasal Continuous Positive Airway Pressure (nCPAP) treatment
    P Jennum
    Department of Clinical Neurophysiology, Glostrup Hospital, Denmark
    Am J Hypertens 2:847-52. 1989
    ..With nCPAP the arterial pressure variations disappeared. Awake morning systolic (SBP) and diastolic (DBP) blood pressure decreased the nCPAP treatment...
  65. ncbi The uptake and metabolism of 25-hydroxyvitamin D3 and vitamin D binding protein by cultured porcine kidney cells (LLC-PK1)
    M J Keenan
    Human Nutrition and Food, School of Human Ecology, Louisiana State University, Baton Rouge 70803 4300
    Int J Biochem 23:1225-30. 1991
    1. Uptake of 3H-25OHD3, 3H-25OHD3-DBP, 125I-holo-DBP and 125I-apo-DBP by LLC-PK1 cells was linearly related to the concentration of each in the culture media...
  66. ncbi A telecommunications system for monitoring and counseling patients with hypertension. Impact on medication adherence and blood pressure control
    R H Friedman
    Medical Information Systems Unit, Boston University Medical Center Hospital, MA 02118, USA
    Am J Hypertens 9:285-92. 1996
    ..medication, with a systolic blood pressure (SBP) of >or= 160 mm Hg and/or a diastolic blood pressure (DBP) of >or= 90 mm Hg...
  67. ncbi [Effects of deprivation and replacement by percutaneous 17 beta estradiol and oral progesterone on blood pressure and metabolic parameters in menopause patients with non-insulin-dependent diabetes]
    H Mosnier-Pudar
    , , Paris
    Arch Mal Coeur Vaiss 84:1111-5. 1991
    ..Systolic (SBP) and diastolic (DBP) blood pressure were monitored by an automatic device at inclusion and on the 1st, 3rd and 6th months of therapy...
  68. ncbi [Are demographic characteristics of hypertensive patients different with renal artery stenosis?]
    O Jaboureck
    Service de médecine interne et HTA, Hopital Cardiologique, CHRU, 59037 Lille
    Arch Mal Coeur Vaiss 94:828-33. 2001
    ..The goal of this work was to study the demographic differences between hypertensive patients with renal artery stenosis (RAS) or without RAS...
  69. ncbi CD44 and annexin A2 mediate the C5a chemotactic cofactor function of the vitamin D binding protein
    Lauren A McVoy
    Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA
    J Immunol 175:4754-60. 2005
    The vitamin D binding protein (DBP) is a plasma protein that significantly enhances the chemotactic activity of C5a and C5a(desArg) (cochemotactic activity)...
  70. doi Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism
    Cynthia S Ritter
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 112:1348-52. 2011
    ..Eldecalcitol has a higher affinity for the serum vitamin D-binding protein (DBP), and therefore binding to DBP, and possibly other serum components, appears to limit the uptake and activity of ..
  71. ncbi [Effects of octreotide on experimental orthostatic neurogenic hypotension]
    P Verwaerde
    , INSERM U317,
    Arch Mal Coeur Vaiss 89:1097-1101. 1996
    ..In controls, as expected, head-up tilt test induced a significant increase in DBP (+14 +/- 8 mmHg), HR (+36 +/- 21 beat/min), NA (296 +/- 118 vs 141 +/- 63 pg/ml), SBP-LF (25 +/- 5 vs 14 +/- 3%) ..
  72. ncbi Effects of race and ethnicity on insulin sensitivity, blood pressure, and heart rate in three ethnic populations: comparative studies in African-Americans, African immigrants (Ghanaians), and white Americans using ambulatory blood pressure monitoring
    K Osei
    Department of Medicine, The Ohio State University Medical Center, Columbus 43210-1296, USA
    Am J Hypertens 9:1157-64. 1996
    ..56 +/- 1.07). The mean systolic (SBP) and diastolic blood pressure (DBP) and heart rates (HR) during 24-h and daytime periods were not significantly different in the African-Americans and ..
  73. ncbi Factors affecting blood pressure responses to diet: the Vanguard study
    L M Resnick
    Hypertension Center, New York-Presbyterian Hospital/Cornell University Medical Center, New York 10021, USA
    Am J Hypertens 13:956-65. 2000
    ..0001/P < .0001), and on CCNW versus SSD diets (delta systolic BP [SBP]/delta diastolic BP [DBP], P = .033/P = .002). Diet-induced weight change was the strongest correlate of changes in BP (SBP: r = 0...
  74. ncbi Lack of independent relationships between left ventricular mass and cardiovascular reactivity to physical and psychological stress in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    J H Markovitz
    University of Alabama at Birmingham 35205, USA
    Am J Hypertens 9:915-23. 1996
    ..Diastolic blood pressure (DBP) reactivity to the video game was related to LVM only among black men in adjusted analyses...
  75. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
    ..As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to ..
  76. ncbi Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta
    D J Whitworth
    Department of Integrative Biology, University of California at Berkeley, 94720, USA
    Gen Comp Endocrinol 118:354-8. 2000
    Vitamin D-binding protein (DBP) is the major transport protein for the vitamin D sterols in a variety of mammalian and avian species...
  77. ncbi [Development of blood pressure level over a three years period in non-insulin dependent diabetic subjects according to their microalbuminuria]
    H Mayaudon
    , ,
    Arch Mal Coeur Vaiss 89:1045-9. 1996
    ..following elements are compared at A0 and A3: body mass index (BMI), systolic (SBP) and diastolic blood pressure (DBP), serum creatinine, cholesterol and triglycerides. RESULTS: The two groups do not differ in age (57.1 +/- 12 vs 53...
  78. ncbi Life style as a determinant of blood pressure in the general population
    J A Staessen
    Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Am J Hypertens 7:685-94. 1994
    ..which life style factors were correlated with the level and the variability of systolic (SBP) and diastolic (DBP) pressure in a random population sample...
  79. ncbi Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma parathyroid hormone and calcium and phosphate metabolism
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Eur J Endocrinol 146:635-42. 2002
    ..We have studied whether plasma levels of 1,25(OH)(2)D and vitamin D-binding protein (DBP) vary in a diurnal rhythm in postmenopausal women.
  80. ncbi Platelet-derived thrombospondin-1 is necessary for the vitamin D-binding protein (Gc-globulin) to function as a chemotactic cofactor for C5a
    Glenda Trujillo
    Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA
    J Immunol 173:4130-6. 2004
    The chemotactic activity of C5a and C5a des Arg can be enhanced significantly by the vitamin D-binding protein (DBP), also known as Gc-globulin...
  81. pmc Enhanced excretion of vitamin D binding protein in type 1 diabetes: a role in vitamin D deficiency?
    Kathryn M Thrailkill
    Department of Pediatrics, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Clin Endocrinol Metab 96:142-9. 2011
    ..Vitamin D deficiency is an increasingly recognized comorbidity in patients with both type 1 (T1D) and type 2 diabetes, particularly associated with the presence of diabetic nephropathy...
  82. doi Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages
    A M Wood
    School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Thorax 66:205-10. 2011
    Vitamin D-binding protein (DBP) genetic polymorphisms have been associated with chronic obstructive pulmonary disease (COPD)...
  83. ncbi Electrophoretic mobility shift assay identifies vitamin D binding protein (Gc-globulin) in human, rat, and mouse sera
    W X Tang
    Department of Medicine, University of Pennsylvania, School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania, 19104 6149, USA
    Anal Biochem 237:245-51. 1996
    Serum vitamin D binding protein (DBP, also known as Gc-globulin) is a multifunctional protein capable of binding both vitamin D metabolites and actin...
  84. ncbi Measurement of vitamin D-binding protein in pleural fluids and sera by means of a turbidimetric immunoassay measuring system
    Yoshio Hamashima
    Department of Respiratory Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, 2 1 50 Minamikoshigaya, Saitama, 343 8555, Japan
    Clin Chim Acta 321:23-8. 2002
    Vitamin D-binding protein (DBP) has been recognized as a multifunctional plasma protein that can modulate certain immune and inflammatory responses...
  85. ncbi Elevated urinary levels of vitamin D-binding protein in the inhabitants of a cadmium polluted area, Jinzu River basin, Japan
    Mitsuo Uchida
    Department of Public Health, Faculty of Medicine, University of Toyama, Japan
    Tohoku J Exp Med 211:269-74. 2007
    ..Vitamin D-binding protein (DBP) binds, transports and activates vitamin D, which plays a major role in calcium homeostasis and bone turnover...
  86. doi Investigation of the potential association of vitamin D binding protein with lipoproteins
    Marijn M Speeckaert
    Department of Clinical Chemistry, Ghent University Hospital, Gent, Belgium
    Ann Clin Biochem 47:143-50. 2010
    b>Vitamin D binding protein (DBP) acts as a vitamin D carrier and an actin scavenger. We have previously reported a correlation between serum DBP and lipid parameters in a cystic fibrosis population...
  87. doi Inverse association between serum concentrations of actin-free vitamin D-binding protein and the histopathological extent of fibrogenic liver disease or hepatocellular carcinoma
    Olav Axel Gressner
    Institute of Clinical Chemistry and Pathobiochemistry Central Laboratory, RWTH University Hospital, Pauwelsstrasse 30, Aachen 52074, Germany
    Eur J Gastroenterol Hepatol 21:990-5. 2009
    ..as a carrier protein for vitamin D and its plasma metabolites, the primary function of vitamin D-binding protein (DBP; Gc-globulin) is to serve and to bind and neutralize extracellular monomeric actin (G-actin) released from necrotic ..
  88. pmc Cardiovascular effects of GR117289, a novel angiotensin AT1 receptor antagonist
    A Hilditch
    Department of Cardiovascular and Respiratory Pharmacology, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 111:137-44. 1994
    1. The effect of GR117289, an angiotensin AT1 receptor antagonist, on diastolic blood pressure (DBP) was determined in angiotensin-dependent and angiotensin-independent models of hypertension in rats...
  89. pmc Retinoids modulate expression of the endocytic partners megalin, cubilin, and disabled-2 and uptake of vitamin D-binding protein in human mammary cells
    Timothy M Chlon
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr 138:1323-8. 2008
    ..circulating form of vitamin D, 25-hydroxycholecalciferol (25D3), circulates bound to vitamin D-binding protein (DBP)...
  90. ncbi Proximal tubule endocytic apparatus as the specific renal uptake mechanism for vitamin D-binding protein/25-(OH)D3 complex
    Armando Luis Negri
    Physiology and Biophysics Department, Universidad del Salvador School of Medicine, Buenos Aires, Argentina
    Nephrology (Carlton) 11:510-5. 2006
    ..Recent studies have shown that vitamin D-binding protein (DBP)/25-(OH)D3 complex is one of the megalin/cubilin ligands...
  91. ncbi Factors related to the presence of microalbuminuria in essential hypertension
    J Redon
    Hypertension Clinic, Hospital of Sagunto, Valencia, Spain
    Am J Hypertens 7:801-7. 1994
    ..UAE 30 to 300 mg/24 h) occurred in 26% of patients and was associated with higher diastolic blood pressure (DBP), left ventricular mass index (LVMI), and a higher prevalence of hypertriglyceridemia and hyperapolipoproteinemia B ..
  92. ncbi Effect of atenolol and reserpine on selected events in the systolic hypertension in the elderly program (SHEP)
    J B Kostis
    Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903-0019, USA
    Am J Hypertens 8:1147-53. 1995
    ..The average baseline SBP/DBP was 170/77 mm Hg. In the active treatment group, step 1, dose 1 was chlorthalidone, 12...
  93. ncbi [Renal artery stenosis and chronic renal failure in NIDDM]
    J P Courreges
    Service de Medecine Interne A, Centre Hospitalier, Narbonne
    Arch Mal Coeur Vaiss 91:1077-82. 1998
    ..All hypertensive patients were treated (mean SBP: 148 +/- 16, mean DBP: 82 +/- 7 mmHg) and had 62 +/- 28% SBP escape and 33 +/- 19% DBP escape...
  94. ncbi [Differences between management guidelines and global health strategies for arterial hypertension with metabolic disorders in France in 1999. Ohara study]
    J M Mallion
    CHU Michallon, 38043 Grenoble
    Arch Mal Coeur Vaiss 94:834-8. 2001
    ..The percentage of patients reaching target BP was 59% as regard DBP < 90 mmHg, 25% as regard SBP < 140 mmHg, and 23% reached both target values of BP...
  95. pmc Correlates of controlled hypertension in indigent, inner-city hypertensive patients
    J S Ahluwalia
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    J Gen Intern Med 12:7-14. 1997
    ..Control patients had a systolic blood pressure (SBP) < or = 140 mm Hg and diastolic blood pressure (DBP) < or = 90 mm Hg, and case patients had a SBP > or = 180 mm Hg or DBP > or = 110 mm Hg...
  96. ncbi Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1beta
    Y H Song
    Departments of Medicine and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:28408-18. 1998
    Vitamin D-binding protein (DBP)/Gc-globulin, the major carrier of vitamin D and its metabolites in blood, is synthesized predominantly in the liver in a developmentally regulated fashion...
  97. ncbi Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes
    J C Ongagna
    Centre Européen d Etude du Diabète, Boulevard René Leriche, 67200 Strasbourg, France
    Clin Biochem 38:415-9. 2005
    Vitamin D-binding protein (DBP) is the main systemic transporter of 1.25(OH)2D3 and is essential for its cellular endocytosis...
  98. ncbi Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Clin Endocrinol (Oxf) 67:259-64. 2007
    ..We hypothesized that these findings might be explained by effects of these variables on vitamin D binding protein (DBP) levels...
  99. pmc Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Endocrinology 149:3656-67. 2008
    Mice deficient in the expression of vitamin D-binding protein (DBP) are normocalcemic despite undetectable levels of circulating 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]...
  100. doi Vitamin D binding protein and the need for vitamin D in hemodialysis patients
    Marijn M Speeckaert
    Department of Clinical Chemistry, University of Ghent, Ghent University Hospital, Ghent, Belgium
    J Ren Nutr 18:400-7. 2008
    b>Vitamin D binding protein (DBP) is a polymorphic serum protein with a predominant role in a spectrum of biological activities. Chronic renal failure is characterized by deficient vitamin D metabolism...
  101. pmc Identification of two distinct cell binding sequences in the vitamin D binding protein
    Jianhua Zhang
    Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    Biochim Biophys Acta 1803:623-9. 2010
    The vitamin D binding protein (DBP) is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions...

Research Grants73

  1. Mechanisms of the Relaxation Response in Elderly Hypertensives
    Jeffery A Dusek; Fiscal Year: 2010
    ..blood pressure in older Systolic Hypertension (defined as SBP >140 mm Hg with normal diastolic blood pressure (DBP <90 mm Hg) patients could contribute significantly to the treatment of this condition...
  2. Air Pollution and Cardiac Risk: Mechanisms & Time-course
    Duanping Liao; Fiscal Year: 2010
    ..this association be totally or partially attributed to the change of HRV and QT? (6) elevated ambulatory BP (SBP, DBP, and PP)? What are the time-courses (from minutes to hours) of the effects listed from 1-6 above? (7) Is personal ..
  3. Interactive Web Program and Health Coaching for Prehypertensive Adults
    AMELIA J BIRNEY; Fiscal Year: 2013
    ..provided by applicant): Approximately a third (31%) of adult Americans are prehypertensive (SBP 120-139 and/or DBP 80-89)...
  4. A Genome-Wide Association Study in Essential Hypertension (FEHGAS2)
    Aravinda Chakravarti; Fiscal Year: 2013
    ..5% of the inter-individual variation in systolic- (SBP) and diastolic- (DBP) blood pressure, with concomitant effects on HTN...
  5. Interactive Program to Prevent Hypertension in Prehypertensive Seniors
    AMELIA BIRNEY; Fiscal Year: 2009
    ..applicant): Nearly a quarter (24%) of older Americans (>60 yrs) have prehypertension (SBP 120-139 mm Hg and/or DBP 80-89 mm Hg)...
  6. Classical and non-classical responses to vitamin D in children: the role of DBP g
    Thomas O Carpenter; Fiscal Year: 2010
    ..Moreover, our recent analysis of vitamin D status in these children reveals that vitamin D binding protein (DBP) genotype is a significant predictor of 25-OHD and 1,25 dihydroxyvitamin D [1,25 (OH)2D] levels...
  7. Yiqing Song; Fiscal Year: 2016
    ..b>Vitamin D binding protein (VDBP), the major vitamin D carrier protein, plays a key role in regulating vitamin D bioavailability ..
  8. A Partnership to Promote Physical Activity and Healthy Eating in AME Churches
    Sara Wilcox; Fiscal Year: 2010
    ..Primary outcomes, measured at baseline and 18- months, are blood pressure (SBP, DBP), PA (self-reported mins/wk);and F&V consumption (svgs/d)...
  9. MULTI-SITE RCT FOR BP CONTROL IN HTN AFRICAN AMERICANS
    GBENGA GODWIN OGEDEGBE; Fiscal Year: 2011
    ..The secondary outcomes are within-patient change in SBP and DBP from baseline to 12 months;the maintenance of the intervention effects one year after trial;and the cost ..
  10. Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension
    Nelson Ruiz-Opazo; Fiscal Year: 2013
    ..and the development of salt-sensitive hypertension (measured via non-stress 24/7 telemetric BP analysis of SBP, DBP, MAP and PP) and stroke in both male and female stroke-prone Dahl S rats. Aim 2...
  11. Assessing Workplace Phthalate Exposures Among Massage Therapy Students
    VICTORIA PAK; Fiscal Year: 2010
    ..of the urinary biomarkers MEP and MBP, the main metabolites of Diethyl Phthalate (DEP) and Dibutyl Phthalate (DBP) in massage therapist students, while controlling for personal product usage, age, body mass index (BMI), and ..
  12. Phthalates in Drugs and Male Genital Malformation
    Allen A Mitchell; Fiscal Year: 2012
    ..g., diethyl phthalate [DEP] and di-n-butyl phthalate [DBP]) to make coatings for oral medications;phthalates are used to target medication release (e.g...
  13. Shanna H Swan; Fiscal Year: 2014
    ..In rodents, diethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP) induce a spectrum of male genital tract disorders termed the "phthalate syndrome"...
  14. JULIE BETH HERBSTMAN; Fiscal Year: 2014
    ..ES013543, Robin Whyatt, PI): di(2-ethylhexyl) phthalate (DEHP), butylbenzyl phthalate (BBzP) and dibutyl phthalate (DBP). Exposures to these phthalates are substantial among cohort subjects...
  15. Kim Boekelheide; Fiscal Year: 2014
    ..Rats exposed to di-(n-butyl)phthalate) (DBP) during a critical in utero window of male reproductive tract development have decreased fetal testicular ..
  16. Diana J Laird; Fiscal Year: 2015
    ..to a range of environmentally relevant doses of di-(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP)...
  17. Russ B Hauser; Fiscal Year: 2014
    ..the environment and reproductive health, we found a suggestive association between exposure to dibutyl phthalate (DBP) and reduced semen quality...
  18. Epigenetic Changes After Intrauterine Exposure to Endocrine Disrupting Chemicals
    KARIN MICHELS; Fiscal Year: 2009
    ..Further it is hypothesized that intrauterine exposure to bisphenol A and the phthalates DEHP, DBP, and BBP induces hypomethylation of the ERa gene and thereby increases ERa transcription expression...
  19. Effect of chronic low-dose phthalate exposure on the immature primate testis
    Ina Dobrinski; Fiscal Year: 2009
    ..Di-n-butyl phthalate (DBP) is commonly found in personal care products and fetal exposure to DBP affects male reproductive tract development ..
  20. Genomic approach to phthalate action on fetal testes
    Kevin Gaido; Fiscal Year: 2004
    ..changes in gene expression in the developing rat testis following in utero exposure to di(n-Butyl) phthalate (DBP) were examined...
  21. Mechanism of Phthalate Induced Testicular Toxicity
    Kevin Gaido; Fiscal Year: 2007
    ..changes in gene expression in the developing rat testis following in utero exposure to di(n-butyl) phthalate (DBP) were examined...
  22. Pharmacokinetics of DBP in utero to Assess Human Risk
    John Kremer; Fiscal Year: 2004
    Di-n-butyl phthalate (DBP) is a phthalic acid ester and a widespread environmental contaminant. DBP is a known reproductive toxicant in rats and mice, with adverse effects arising from the monoester metabolite - monobutyl phthalate (MBP)...
  23. Saurabh Chatterjee; Fiscal Year: 2014
    ..and post-translation oxidation adducts of proteins in obese mice in response to the disinfection byproduct (DBP) bromodichloromethane (BDCM)...
  24. Christina Porucznik; Fiscal Year: 2015
    ..The contaminants selected for measurement, disinfection by-products (DBP) and bisphenol-A (BPA), have been associated with adverse reproductive outcomes in animal models and in limited ..
  25. Genetic Variants Influencing Response to Vitamin D in Colorectal Chemoprevention
    Elizabeth L Barry; Fiscal Year: 2012
    ..in or near genes coding for key proteins associated with vitamin D transport and metabolism: 1) the vitamin D binding protein (DBP), 2) the enzyme 7-dehydrocholesterol reductase (DHCR7), 3) the 25-hydroxylase enzyme CYP2R1, and 4) ..
  26. The Removal of Disinfection Byoproducts from Water (1000-641)
    ARJAN GIAYA; Fiscal Year: 2007
    ..Current methods for DBP removal tend to focus on the reduction of NOM prior to the chlorination process...
  27. MINIATURE SYSTEM FOR REMOVAL OF DISINFECTION BYPRODUCTS
    K McKenzie; Fiscal Year: 2000
    ..Current treatment technologies available for DBP removal at the plant level do not provide a practical, economic or logistical solution...
  28. MECHANISMS OF INTESTINAL CARCINOGENESIS OF DISINFECTION
    Daniel Rosenberg; Fiscal Year: 2001
    ..studies, we propose to evaluate the carcinogenic potential of an important drinking water disinfection bi-product (DBP), bromodichloromethane (BDCM)...
  29. A NOVEL REAL TIME MONITOR FOR DBP'S IN DRINKING WATER
    WAHEGURU SINGH; Fiscal Year: 2000
    ..abstract_text> ..
  30. CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISM
    John Adams; Fiscal Year: 2004
    ..e. megalin- bound serum vitamin D binding protein, other IDBPs, the vitamin- D-hydroxylases, vitamin D receptor) to facilitate the movement of ligand from ..
  31. VITAMIN D REQUIREMENT OF INFANTS
    Bruce Hollis; Fiscal Year: 1990
    ..this phototherapy of the mother affects the mineral homeostasis of the nursing infant; 4) determine the vitamin D binding protein content of the mothers' plasma and milk in an effort to gain better insight into the transfer of vitamin ..
  32. NATURAL IMMUNITY AND BONE RESORPTION
    Gary Schneider; Fiscal Year: 1999
    ..Mutant ia rats demonstrate defects in the cascade involved in the conversion of vitamin D binding protein (DBP) to a potent macrophage activating factor (DBP-MAF)...
  33. STRUCTURE/FUNCTION STUDIES OF VITAMIN D BINDING PROTEIN
    Rahul Ray; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Vitamin D-binding protein (DBP) binds vitamin D and its metabolites as well as G-actin with high affinity and serves to transport the former to target tissues, and to scavenge the ..
  34. Diet, Biomarkers and Lung Function
    Rui Jiang; Fiscal Year: 2010
    ..This proposal will prepare the candidate well to apply successfully for R01 on diet, diet-related genes, and gene-diet interactions in lung function and COPD. ..
  35. Michelle Denburg; Fiscal Year: 2016
    ..FSGS), was an independent risk factor for low total and free 25(OH) D levels and vitamin D-binding protein (DBP) in children with chronic kidney disease...
  36. HYPERTENSION IN AFRICAN-AMERICAN WOMEN
    Ashok Kumar; Fiscal Year: 2004
    ..AG gene is primarily expressed in the liver and we have shown that liver enriched transcription factors HNF4 and DBP, and ubiquitous transcription factors SP1 and CREB play important role in liver specific expression of this gene...
  37. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ..Rats exposed to di-(n-butyl)phthalate) (DBP) during critical in utero window of male reproductive tract development have altered gene expression and a number ..
  38. C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    Mario Chojkier; Fiscal Year: 2012
    ..have reported the isolation of a clone encoding for the CCAAT/Enhancer Binding Protein (C/EBP)I3 (LAP, NF-IL6, IL6-DBP), a liver-enriched activator protein that confers liver-specific gene expression...
  39. Juvenile Osteopetrosis: DBP-MAF, A New Therapeutic Agent
    Narasimha Swamy; Fiscal Year: 2002
    ..osteopetrosis) has been recently shown to be due to a generalized defect in enzymatic conversion of DBP (vitamin D binding protein) to DBP-MAF by T- and B- lymphocytes in both humans and animal models...
  40. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2011
    ..Previously, several groups have shown that the vitamin D binding protein (DBP), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
  41. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..directly involved in the metabolism of vitamin D: 25-hydroxylase (CYP27A1), 1a-hydroxylase (CYP27B1), vitamin D binding protein (GC), 24- hydroxylase (CYP24A1), vitamin D receptor (VDR), and retinoic acid receptor alpha (RARA)...
  42. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2012
    ..CYP27B1)], co-activation (NCOA1-3, SMAD3), deactivation [24-hydroxylase (CYP24A1)], transport [vitamin D binding protein encoded by group- specific component (GC)], and vitamin D signaling [retinoid X receptors (RXRA, RXRB, ..
  43. Vitamin D3 Metabolism and Colorectal Cancer: Correlating Phenotype to Genotype
    Josephia R Muindi; Fiscal Year: 2011
    ..Furthermore, genotyping studies of the 74 tagSNPs in the key vitamin D3 metabolism genes (DBP, VDR, CYP27A1, CYP27B1 and CYP24A1) revealed a significant association between rs4588 polymorphism, a non-..
  44. John H Adams; Fiscal Year: 2016
    ..Our long-term goal is to optimize efficacy of DBPII as a broadly effective vaccine that elicits antibodies to conserved strain-transcending neutralizing epitopes. ..
  45. MARY BETH LEONARD; Fiscal Year: 2016
    ..levels that will capture cumulative effects over a 4-year interval, and assessment of the effects of vitamin D binding protein to potentially modify the association between 25(OH)D levels and CKD progression...
  46. BIOMEDICAL ANALYSIS OF HUMAN BIOSPECIMENS FOR DIPHR
    ERIN ALLEN; Fiscal Year: 2013
    ..for Preeclampsia Prevention trial (CPEP) to measure total 25(0H)D, its isoforms (25(0H)D2 and 25(0H)D3), Vitamin D binding protein (VDBP), albumin, and total calcium in up to 992 serum samples from the CPEP trial...
  47. Dissecting the Molecular Mechanisms of Canonical Wnt Signaling
    Raymond Habas; Fiscal Year: 2013
    ..We have identified this molecule termed DBP, for Dishevelled Binding Molecule, via a yeast-two hybrid screen using Dvl as a bait...
  48. Vitamin D, Related Genes and Breast Cancer Risk
    Anne Zeleniuch-Jacquotte; Fiscal Year: 2013
    ..We will also assess genetic variation in vitamin D-related genes (CYP27A1, CYP24A1, DBP, VDR, and RXRA) and evaluate the joint effects of circulating 25(OH)D and variants in these genes on breast cancer ..
  49. Martin Hewison; Fiscal Year: 2016
    ..that the ability of 25D to access target cells is influenced by its association with the serum vitamin D binding protein (DBP), with 'free'rather than 'DBP-bound'25D being the bioactive form of this ..
  50. Ravi Thadhani; Fiscal Year: 2016
    ..blacks be treated with vitamin D to prevent osteoporosis? We propose to investigate a novel concept that vitamin D binding protein (VDBP), in the context of the "free hormone hypothesis," underlies the physiological mechanisms of this ..
  51. Identification of Candidate Genes at the Synapse in Autism Spectrum Disorders
    ABHA RANI GUPTA; Fiscal Year: 2013
    ..that integrates the fields of human genetics, molecular neuroscience, and developmental-behavioral pediatrics (DBP). Dr...
  52. Low CV Risk, Ages 25-44 & CV/non-CV Outcomes, Ages 65+
    Martha L Daviglus; Fiscal Year: 2010
    ..readily measurable major risk factors, as defined in national policy recommendations and objectives for 2010 (SBP/DBP <120/<80 mmHg, serum total cholesterol <200 mg/dl, BMI<25 kg/m2, no smoking, no diabetes, no MI history)..
  53. Tracy M Handel; Fiscal Year: 2014
    ..the CCR5 receptor with the HIV glycoprotein gp120, and the DARC receptor with the malarial docking protein, DBP. Site Directed Spin Labeling with Electron Paramagnetic Resonance (SDSL-EPR) will be used to characterize the ..
  54. Structural Interactions of Bacterial Adhesin with Glycosaminoglycans
    Xu Wang; Fiscal Year: 2010
    ..The focus of the proposal will be on the decorin binding protein (dbp), an adhesin from Borrelia burgdorferi, the etiological agent of Lyme disease...
  55. BRIAN DAVID ATHEY; Fiscal Year: 2016
    ..all the while engaging in cutting-edge collaborative research featuring a strong "driving biological problem" (DBP) application, often leading BTP trainees to have a strong T1 Translational Research orientation...
  56. Richard D Smith; Fiscal Year: 2016
    ..The scope of the new DBP applications include the areas of protein quantification in signal transduction pathways, lipid-binding protein ..
  57. Structural Interactions of Bacterial Adhesin with Glycosaminoglycans
    Xu Wang; Fiscal Year: 2013
    ..The focus of the proposal will be on the decorin binding protein (dbp), an adhesin from Borrelia burgdorferi, the etiological agent of Lyme disease...
  58. Towards Optimal treatment matching for brief motivational interventions
    Susan E Collins; Fiscal Year: 2012
    ..The current study will also test the decisional balance proportion (DBP), or the proportion of participant-generated pros of reducing drinking and cons of current drinking to the total ..
  59. AMINO ACIDS IN URINE, DIET & BP: INT'L POPULATION STUDY
    Martha Daviglus; Fiscal Year: 2003
    ..acids, two 24-hour urine specimens/person with data on Na, K, urea N, creatinine, volume; eight standardized SBP/DBP measurements/person; other data)...
  60. Jack H Freed; Fiscal Year: 2016
    ..with biomedical researchers will greatly benefit from these TR&D's, which in turn are driven by the DBP needs for the new and improved ESR technologies...
  61. Collaborative Mental Health Services for Behavior Disorders in Primary Care
    David Kolko; Fiscal Year: 2012
    ..Care;MH63272) by seeking to more efficiently and effectively treat children with a disruptive behavior problem (DBP) in the pediatric primary-care setting...
  62. MATERNAL VITAMIN D STATUS AND MEASURES OF NEONATAL BONE MINERAL CONT
    ERIN ALLEN; Fiscal Year: 2013
    ..for Preeclampsia Prevention trial (CPEP) to measure total 25(0H)D, its isoforms (25(0H)D2 and 25(0H)D3), Vitamin D binding protein (VDBP), albumin, and total calcium in up to 992 serum samples from the CPEP trial...
  63. VITAMIN D BINDING PROTEIN
    Nancy Cooke; Fiscal Year: 2003
    b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
  64. CENTER FOR BIOMEDICAL OCT RESEARCH AND TRANSLATION
    Brett E Bouma; Fiscal Year: 2011
    ..Projects that could serve more than one DBP or that represented a synergistic combination were identified to be particularly attractive for the initial efforts ..
  65. GENETIC CONTRIBUTIONS TO RISK FACTORS IN LJP
    THOMAS HART; Fiscal Year: 1999
    ..neutrophil receptors C5a, fMLP, and IL-8, as well as GP1 10, diacylglycerol kinase, annexin Ill and the vitamin D binding protein. Our study cohort will consist of 40 African American families (300 individuals) segregating for LJP...
  66. Cancer prevention by indole-3-carbinol via modulation of the epigenome
    Abby D Benninghoff; Fiscal Year: 2010
    ..A recent study using a dibenzo(a,l)pyrene (DBP) transplacental mouse cancer model showed that maternal consumption of I3C during pregnancy and lactation markedly ..
  67. HOST DEFENSES IN SYSTEMIC LUPUS ERYTHEMATOSUS
    H Perez; Fiscal Year: 1991
    One objective of the proposed research is to examine the interaction between vitamin D-binding protein (i.e., Gc globulin, DBP), the complement (C5)-derived peptide, C5a des Arg, and the Bb fragment of complement factor B...
  68. Genetic Variation in Vitamin D Metabolism and BMT Outcomes
    KIMBERLY ROBIEN; Fiscal Year: 2009
    ..or combinations of genotypes, in the vitamin D metabolic pathway (CYP2R1, CYP3A4, CYP27A1, CYP27B1, vitamin D binding protein, and CYP24A1) are associated with risk of acute GVHD, disease relapse, and survival among individuals ..
  69. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2007
    ..Previously, several groups have shown that the vitamin D binding protein (DBF), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
  70. BONE RESORPTION--IMMUNE AND ENDOCRINE RELATIONSHIPS
    STEVEN POPOFF; Fiscal Year: 1999
    ..a defect in inflammation-primed macrophage activation resulting from the inability to convert serum vitamin D binding protein .(DBP) to a potent macrophage activating factor (DBP-MAF)...
  71. Cardiovascular Causes of Falls/Syncope in the Elderly
    Mathew Maurer; Fiscal Year: 2005
    ..to determine if the timing and degree of postural changes in BP adds prognostic value, if changes in SBP and DBP are equivalent in predicting subsequent falls in order to determine what degree of decline in BP has the best ..
  72. Zebrafish Carcinogenesis and Cytochrome P450 Expression
    DONALD BUHLER; Fiscal Year: 2004
    ..zebrafish are relatively resistant to certain carcinogens such as aflatoxin B1 (AFB1) and dibenzo[a,1]pyrene (DBP), thus reducing their utility as carcinogenesis models...
  73. KEVIN EDUARD HAUSER; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): DNA-binding proteins (DBP) are the primary molecules regulating the expression of DNA. The goal of this proposal is to develop a model of protein-DNA binding and recognition...