VIP

Summary

Gene Symbol: VIP
Description: vasoactive intestinal peptide
Alias: PHM27, VIP peptides, prepro-VIP
Species: human

Top Publications

  1. ncbi A VIP hybrid antagonist: from developmental neurobiology to clinical applications
    I Gozes
    Department of Clinical Biochemistry, Tel Aviv University, Israel
    Cell Mol Neurobiol 15:675-87. 1995
  2. ncbi Combination chemotherapy with vinblastine, ifosfamide and cisplatin in bulky seminoma
    C Clemm
    Department of Internal Medicine III, University of Munich, West Germany
    Acta Oncol 28:231-5. 1989
  3. pmc The mechanisms of the relaxation induced by vasoactive intestinal peptide in the porcine coronary artery
    J Kawasaki
    Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 121:977-85. 1997
  4. ncbi [Evaluation of commercial kits for a rapid detection of Escherichia coli O157 in stool]
    T Tsukamoto
    Osaka Prefectural Institute of Public Health
    Kansenshogaku Zasshi 72:40-4. 1998
  5. ncbi Active immunization with vasoactive intestinal peptide in turkey hens
    M E El-Halawani
    Department of Animal Science, University of Minnesota, Saint Paul 55108, USA
    Poult Sci 79:349-54. 2000
  6. ncbi The vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamics
    Emilie Ceraudo
    Institut National de la Santé et de la Recherche Médicale Unité 773, Centre de recherche Biomedicale Bichat Beaujon, CRB3, Faculte de Medecine Xavier Bichat, 75018, Paris, France
    Mol Endocrinol 22:147-55. 2008
  7. ncbi VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res 838:27-36. 1999
  8. ncbi Vasoactive intestinal peptide increases vascular endothelial growth factor expression and neuroendocrine differentiation in human prostate cancer LNCaP cells
    Beatriz Collado
    Molecular Neuroendocrinology Unit, Department of Biochemistry and Molecular Biology, Alcala University, E 28871 Alcala de Henares, Spain
    Regul Pept 119:69-75. 2004
  9. ncbi Vasoactive intestinal peptide (VIP) increases vascular endothelial growth factor (VEGF) expression and secretion in human breast cancer cells
    Ana Valdehita
    Molecular Neuroendocrinology Unit, Department of Biochemistry and Molecular Biology, Alcala University, Alcala de Henares 28871, Spain
    Regul Pept 144:101-8. 2007
  10. doi Nuclear localization of vasoactive intestinal peptide (VIP) receptors in human breast cancer
    Ana Valdehita
    Molecular Neuroendocrinology Unit, Department of Biochemistry and Molecular Biology, Alcala University, 28871 Alcala de Henares, Spain
    Peptides 31:2035-45. 2010

Research Grants

  1. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
  2. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
  3. CELLULAR BASIS OF CIRCADIAN RHYTHMS IN MAMMALS
    ERIK HERZOG; Fiscal Year: 2013
  4. VIP--A MEDIATOR OF NEUROIMMUNE INTERACTIONS
    Doina Ganea; Fiscal Year: 2000
  5. ALTERATION WITH AGE OF RESISTANCE TO EYE INFECTIONS
    Linda D Hazlett; Fiscal Year: 2013
  6. DEBTIRTHO DIPON GHOSH; Fiscal Year: 2015
  7. The role of VIP in the Circadian Regulation of Cardiovascular Rhythms
    ANALYNE M SCHROEDER; Fiscal Year: 2011
  8. Doina Ganea; Fiscal Year: 2014
  9. Eosinophil trafficking in fungal allergic asthma
    Glenn Paul Dorsam; Fiscal Year: 2013
  10. Vasoactive intestinal peptide for the treatment of psoriasis
    Sandra Reichstetter; Fiscal Year: 2013

Detail Information

Publications274 found, 100 shown here

  1. ncbi A VIP hybrid antagonist: from developmental neurobiology to clinical applications
    I Gozes
    Department of Clinical Biochemistry, Tel Aviv University, Israel
    Cell Mol Neurobiol 15:675-87. 1995
    1. The 28 amino acid vasoactive intestinal peptide, VIP, was originally isolated from the intestine, following a bioassay measuring vasodilating properties...
  2. ncbi Combination chemotherapy with vinblastine, ifosfamide and cisplatin in bulky seminoma
    C Clemm
    Department of Internal Medicine III, University of Munich, West Germany
    Acta Oncol 28:231-5. 1989
    Since 1982, 24 patients with bulky seminoma were treated with the VIP-regimen consisting of vinblastine 6 mg/m2 days 1+2, ifosfamide 1.5 g/m2 days 1-5, cisplatin 20 mg/m2 days 1-5...
  3. pmc The mechanisms of the relaxation induced by vasoactive intestinal peptide in the porcine coronary artery
    J Kawasaki
    Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 121:977-85. 1997
    1. This study was designed to investigate the mechanism of the relaxation induced by vasoactive intestinal peptide (VIP) in medial strips of the porcine coronary artery, by determining the effect on the cytosolic Ca2+ concentration ([Ca2+..
  4. ncbi [Evaluation of commercial kits for a rapid detection of Escherichia coli O157 in stool]
    T Tsukamoto
    Osaka Prefectural Institute of Public Health
    Kansenshogaku Zasshi 72:40-4. 1998
    ..coli O157 were compared. VIP, Reveal, Path Stik, Quix, Now EH and EZ coli were found to detect E. coli O157 greater than 10(6) CFU/ml...
  5. ncbi Active immunization with vasoactive intestinal peptide in turkey hens
    M E El-Halawani
    Department of Animal Science, University of Minnesota, Saint Paul 55108, USA
    Poult Sci 79:349-54. 2000
    Active immunization of turkey hens against vasoactive intestinal peptide (VIP) has been shown to inhibit incubation behavior and to increase egg production in second-cycle hens...
  6. ncbi The vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamics
    Emilie Ceraudo
    Institut National de la Santé et de la Recherche Médicale Unité 773, Centre de recherche Biomedicale Bichat Beaujon, CRB3, Faculte de Medecine Xavier Bichat, 75018, Paris, France
    Mol Endocrinol 22:147-55. 2008
    The neuropeptide vasoactive intestinal peptide (VIP) strongly impacts on human pathophysiology and does so through interaction with class II G protein-coupled receptors...
  7. ncbi VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res 838:27-36. 1999
    Vasoactive intestinal peptide (VIP) and DAPTA (D-ala(1)-peptide T-amide, a gp120-derived octapeptide homologous to VIP) prevent neuronal cell death produced by five variants of HIV-1 (human immunodeficiency virus) envelope protein (gp120)..
  8. ncbi Vasoactive intestinal peptide increases vascular endothelial growth factor expression and neuroendocrine differentiation in human prostate cancer LNCaP cells
    Beatriz Collado
    Molecular Neuroendocrinology Unit, Department of Biochemistry and Molecular Biology, Alcala University, E 28871 Alcala de Henares, Spain
    Regul Pept 119:69-75. 2004
    Vasoactive intestinal peptide (VIP) upregulates the expression of vascular endothelial cell growth factor (VEGF(189), VEGF(165) and VEGF(121)) mRNAs in human prostate cancer LNCaP cells, as shown by reverse transcriptase-polymerase chain ..
  9. ncbi Vasoactive intestinal peptide (VIP) increases vascular endothelial growth factor (VEGF) expression and secretion in human breast cancer cells
    Ana Valdehita
    Molecular Neuroendocrinology Unit, Department of Biochemistry and Molecular Biology, Alcala University, Alcala de Henares 28871, Spain
    Regul Pept 144:101-8. 2007
    Previous studies have shown that vasoactive intestinal peptide (VIP) and its receptors (VPAC(1) and VPAC(2) receptors) are involved in promotion and growth of many human tumours including breast cancer...
  10. doi Nuclear localization of vasoactive intestinal peptide (VIP) receptors in human breast cancer
    Ana Valdehita
    Molecular Neuroendocrinology Unit, Department of Biochemistry and Molecular Biology, Alcala University, 28871 Alcala de Henares, Spain
    Peptides 31:2035-45. 2010
    Vasoactive intestinal peptide (VIP) and its receptors (VPACs) are involved in proliferation, survival, and differentiation in human breast cancer cells...
  11. doi Expression of synovial fluid and articular cartilage VIP in human osteoarthritic knee: a new indicator of disease severity?
    Wei Jiang
    Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China
    Clin Biochem 45:1607-12. 2012
    Vasoactive intestinal peptide (VIP) is a molecule shared by the neuroendocrine immune network and is considered to be a potential candidate for treatment of inflammatory and autoimmune diseases...
  12. ncbi VIP modulates intracellular calcium oscillations in human lymphoblasts
    P A Anton
    MacDonald Research Laboratories, UCLA School of Medicine 90024
    Immunopharmacol Immunotoxicol 15:429-46. 1993
    Vasoactive intestinal polypeptide (VIP) has been shown to stimulate adenylate cyclase in a human lymphoblast cell line (MOLT 4)...
  13. pmc Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmission
    Y M Qian
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT
    Br J Pharmacol 115:163-71. 1995
    ..5. Investigation of vasoactive intestinal peptide (VIP) as a potential transmitter showed that its inhibitory action on the colon (IC50 = 50 nM) was partially inhibited ..
  14. pmc The influence of the trigeminal ganglion on carotid blood flow in anaesthetized guinea-pigs
    D T Beattie
    Pharmacology II, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 112:262-6. 1994
    ..3. In animals pretreated with guanethidine, intravenous administration of the vasoactive intestinal polypeptide (VIP) receptor antagonist, [p-Cl-D-Phe6,Leu17]-VIP (50 micrograms kg-1) significantly attenuated the increase in carotid ..
  15. pmc Regulation of NANC neural bronchoconstriction in vivo in the guinea-pig: involvement of nitric oxide, vasoactive intestinal peptide and soluble guanylyl cyclase
    Y H Lei
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 108:228-35. 1993
    ..Vasoactive intestinal peptide (VIP, 10 ig kg-' i.v. infused over min) significantly reduced by 70% the increase in PIP induced by NKA (0.1 ...
  16. pmc Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema
    H Inoue
    Research Laboratory, Minophagen Pharmaceutical Co, Kanagawa, Japan
    Br J Pharmacol 110:1614-20. 1993
    ..such as rat calcitonin gene-related peptide (CGRP), SP, neurokinin A (NKA), and vasoactive intestinal peptide (VIP), which are released from capsaicin-sensitive neurones, caused ear oedema by intradermal injection...
  17. ncbi Gastrointestinal hormones and the quantitation of spontaneous duodenal motor activity
    M F Tansy
    Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140
    Toxicol Pathol 16:118-22. 1988
    ..These include vasoactive intestinal polypeptide (VIP), gastric inhibitory polypeptide (GIP), motilin, pancreatic polypeptide (PP), substance P, neurotensin, ..
  18. ncbi Vasoactive intestinal peptide stimulates rat adrenal glucocorticoid secretion, through an ACTH receptor-dependent activation of the adenylate cyclase signaling pathway
    G Mazzocchi
    Department of Anatomy, University of Padua, Italy
    Horm Metab Res 30:241-3. 1998
    Vasoactive intestinal peptide (VIP) concentration-dependently enhanced corticosterone and cyclic-AMP release by dispersed rat inner adrenocortical cells...
  19. ncbi Substance P theory: a unique focus on the painful and painless phenomena of cluster headache
    F Sicuteri
    Institute of Internal Medicine and Therapy, IV, University of Florence, Italy
    Headache 30:69-79. 1990
    ..smooth muscle (of the iris in CH); substance P (SP) and allied transmitters such as Vasoactive Intestinal Peptide (VIP) and Calcitonin Gene-Related Peptide (CGRP) are the main agonists of this dual afferent-efferent function; b) ..
  20. pmc GH4ZD10 cells expressing rat 5-HT1A receptors coupled to adenylyl cyclase are a model for the postsynaptic receptors in the rat hippocampus
    C J Fowler
    Department of Neuropharmacology, CNS Preclinical R and D, Astra Arcus AB, , Sweden
    Br J Pharmacol 107:141-5. 1992
    1. Vasoactive intestinal polypeptide (VIP) stimulated adenosine 3':5'-cyclic monophosphate (cyclic AMP) production by cultured GH4ZD10 cells with an EC50 value of about 7 nM...
  21. ncbi [Role of neuropeptides in dermatology]
    I Sanchez-Carpintero
    Departamento de Dermatologia, Clinica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Espana
    Rev Neurol 25:S222-31. 1997
    ..as substance P (SP), calcitonin gene related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), somatostatin (S), and neurotensin (N). Several NP induce inflammatory response with edema and erythema...
  22. ncbi Modulating effects of sensory and autonomic neuropeptides on murine splenocyte proliferation and cytokine secretion induced by Leishmania major
    A A Ahmed
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 21:507-26. 1999
    ..study was undertaken to investigate the possible immunomodulatory role of sensory (SOM, CGRP and SP) and autonomic (VIP and NPY) neuropeptides in a murine model of cutaneous leishmaniasis, using two genetically different inbred mouse ..
  23. pmc Pituitary adenylate cyclase-activating polypeptide, helospectin, and vasoactive intestinal polypeptide in human corpus cavernosum
    P Hedlund
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 116:2258-66. 1995
    ..polypeptide (PACAP-27 and -38), helospectin (Hel-1 and Hel-2), and vasoactive intestinal polypeptide (VIP), were investigated in isolated preparations of human corpus cavernosum (CC). 2...
  24. ncbi Neuropeptides modulate a murine monocyte/macrophage cell line capacity for phagocytosis and killing of Leishmania major parasites
    A A Ahmed
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 23:397-409. 2001
    ..The autonomic neuropeptides vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) both suppressed the phagocytic and leishmanicidal capacities of macrophages at various ..
  25. pmc Capsaicin-induced relaxation in the rat isolated external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP
    M Parlani
    Menarini Ricerche Sud, Pharmacology Department, Pomezia, Rome, Italy
    Br J Pharmacol 110:989-94. 1993
    ..3-10 microM), but not by substance P (1 microM), vasoactive intestinal polypeptide (VIP, 1 microM), alpha-beta methylene ATP (10 microM), gamma-aminobutyric acid (GABA, 3 mM) or galanin (1 microM)...
  26. ncbi Comparison of the insulinotropic activity of glucagon-superfamily peptides in rat pancreas perfusion
    S Suzuki
    Department of Internal Medicine, University of Tsukuba, Japan
    Horm Metab Res 24:458-61. 1992
    ..having an amino-terminal histidine and carboxy-terminal isoleucine amide (PHI), vasoactive intestinal polypeptide (VIP), growth hormone releasing factor(1-29)amide (GRF), GRF(1-27)amide and synthetic hybrid-peptides of PHI-GRF, PHI(1-..
  27. pmc Mediators of nonadrenergic, noncholinergic inhibition in the proximal, middle and distal regions of rat colon
    N Suthamnatpong
    Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture, Sakai, Japan
    Br J Pharmacol 108:348-55. 1993
    ..NANC relaxation of the proximal segments was still evident after desensitization to vasoactive intestinal peptide (VIP)...
  28. ncbi Neuropeptide Y, tyrosine hydroxylase and vasoactive intestinal polypeptide-immunoreactive nerve fibers in the vertebral bodies, discs, dura mater, and spinal ligaments of the rat lumbar spine
    M Ahmed
    Department of Orthopaedics, Karolinska Institute, Stockholm, Sweden
    Spine (Phila Pa 1976) 18:268-73. 1993
    ..peptidergic nerves, represented by immunoreactivity to neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and noradrenergic nerves as reflected by tyrosine hydroxylase (TH) immunoreactivity, were identified...
  29. ncbi Pancreatic secretagogues regulate somatostatin binding to acinar cell membranes via two-functionally distinct pathways
    T Matozaki
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Horm Metab Res 20:141-4. 1988
    Pretreatment of pancreatic acini with vasoactive intestinal peptide (VIP) or secretin for 120 min reduced subsequent [125I-Tyr1]somatostatin binding to membranes prepared from these acini, with a maximally reduced binding being 79...
  30. pmc Contribution of ATP and nitric oxide to NANC inhibitory transmission in rat pyloric sphincter
    P Soediono
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 113:681-6. 1994
    ..7. While abundant vasoactive intestinal polypeptide (VIP)-containing nerve fibres were demonstrated immunohistochemically in the pyloric sphincter, relaxations to VIP (1 nM-..
  31. ncbi Cholecystokinin and vasoactive intestinal peptide in brain and gut of the hypothyroid neonatal rat
    B Zheng
    Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, New York
    Horm Metab Res 21:127-31. 1989
    ..the concentrations and contents of immunoreactive cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) in the brain and gut of groups of rats exposed to antithyroid medication from day 16 of gestation...
  32. ncbi Lithium inhibits substance P and vasoactive intestinal peptide-induced relaxations on isolated porcine ophthalmic artery
    M B Vincent
    Department of Neurology, Trondheim University Hospital, Norway
    Headache 32:335-9. 1992
    ..Vasoactive intestinal peptide (VIP), SP, CGRP, capsaicin, and SP+CGRP concentration-response relaxation curves were obtained in the presence and ..
  33. ncbi Neuropharmacologic effects of vibration on the dorsal root ganglion. An animal model
    J Weinstein
    University of Iowa, Spine Treatment and Research Center, Iowa City
    Spine (Phila Pa 1976) 13:521-5. 1988
    ..This investigation was undertaken to validate the hypothesis that substance P and VIP, known to be produced in the dorsal root ganglion cell bodies, will be affected by low frequency vibration...
  34. ncbi Vasoactive intestinal peptide potentiates sexual behavior: inhibition by novel antagonist
    I Gozes
    Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel
    Endocrinology 125:2945-9. 1989
    Vasoactive intestinal peptide (VIP) has been suggested as a neurotransmitter mediating penile erection. We now show that VIP can stimulate sexual behavior in rats with reduced masculine potential due to pituitary grafting or castration...
  35. ncbi Modulation of immune function by intestinal neuropeptides
    L P Sirinek
    Department of Pediatrics, Ohio State University, Columbus
    Acta Oncol 30:509-17. 1991
    ..Peptides to be discussed include substance P, somatostatin, vasoactive intestinal peptide (VIP), the opioid peptides leu and met enkephalin, calcitonin gene related peptide (CGRP), neuropeptide Y, and ..
  36. ncbi Prolactin and rapid eye movement sleep regulation
    R Roky
    Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USA
    Sleep 18:536-42. 1995
    ..Stimulation of endogenous PRL secretion by vasoactive intestinal peptide (VIP) also promotes REMS. Immunoneutralization of blood-borne PRL slightly reduces REMS...
  37. ncbi Vasoactive-intestinal-peptide- and substance-P-immunoreactive nerve fibres in the myenteric plexus of mouse colon during the chronic phase of Trypanosoma cruzi infection
    L B Maifrino
    Instituto Dante Pazzanese de Cardiologia, Brazil
    Ann Trop Med Parasitol 93:49-56. 1999
    The distribution of a tachykinin (substance P) and vasoactive intestinal peptide (VIP) and the number and morphology of the large granular vesicles (LGV) in the myenteric plexus of the colons of mice were investigated...
  38. ncbi Vasoactive intestinal polypeptide induces REM recovery in insomniac forebrain lesioned cats
    M T Pacheco-Cano
    Departamento de Neurociencias, ,
    Sleep 13:297-303. 1990
    ..Recently it has been shown that vasoactive intestinal polypeptide (VIP) may be a specific REM inductor in the parachlorophenylalanine (PCPA) insomniac model...
  39. ncbi Neuropeptide changes in compressed spinal nerve roots
    M Cornefjord
    Department of Orthopaedics, Sahlgren Hospital, University of Gothenburg, Sweden
    Spine (Phila Pa 1976) 20:670-3. 1995
    STUDY DESIGN. Compression-induced changes in the concentration of substance P and VIP (vasoactive intestinal polypeptide), in spinal nerve roots and dorsal root ganglia were studied in an experimental nerve root compression model in pigs...
  40. ncbi Opiate modulation of the stress-induced increase of vasoactive intestinal peptide (VIP) in plasma
    T A Crozier
    Zentrum Anaesthesiologie, , Germany
    Horm Metab Res 20:352-6. 1988
    Vasoactive intestinal peptide (VIP) has a variety of extra-intestinal actions which are typical of the body's reaction to stress, such as lipolysis, glycogenolysis and modulation of anterior pituitary hormone secretion...
  41. pmc Effect of diabetes on relaxations to non-adrenergic, non-cholinergic nerve stimulation in longitudinal muscle of the rat gastric fundus
    K M Jenkinson
    Department of Medical Laboratory Science, Royal Melbourne Institute of Technology, Victoria, Australia
    Br J Pharmacol 116:1551-6. 1995
    ..5. Relaxations to both nitric oxide (NO; 1-30 microM) and vasoactive intestinal polypeptide (VIP; 0...
  42. ncbi Protecting effects of vasoactive intestinal polypeptide on lymphocytes against metal toxicity
    K Nordlind
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 14:323-30. 1992
    ..gene-related peptide (CGRP), cholecystokinin (CCK), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP), were investigated for a potential protective effect on thymocytes after a toxic dose of nickel sulfate, giving an ..
  43. ncbi [Vasoactive intestinal peptide in heart failure]
    P Lucia
    II Clinica Medica, , Roma
    Ital Heart J Suppl 1:679-85. 2000
    ..BACKGROUND: The aim of our study was to investigate the pathophysiological role of the vasoactive intestinal peptide (VIP), a vasodilating neuropeptide with positive inotropic and chronotropic properties, in heart failure...
  44. pmc Functional characterization of the adenosine receptor mediating inhibition of intestinal secretion
    D L Hancock
    School of Pharmacology, Unit of Addictive Drug Research, Victorian College of Pharmacy, Monash University, Parkville, Australia
    Br J Pharmacol 114:152-6. 1995
    ..to anaesthetized rats. Intestinal secretion was then stimulated by i.a. infusion of vasoactive intestinal peptide (VIP, 0...
  45. ncbi Vasoactive intestinal polypeptide and neuropeptide-Y, as possible mediators in laryngeal oedema. An immunofluorescence study
    J Basterra
    Surgical Dpt, Valencia Medical School, Spain
    Acta Otorhinolaryngol Belg 43:99-104. 1989
    ..Vasoactive intestinal polypeptide (VIP) and Neuropeptide-Y (NPY) are of interest because of their association with the autonomic nervous system...
  46. ncbi The pain of discography
    J Weinstein
    Spine Diagnostic and Treatment Center, University of Iowa, Iowa City
    Spine (Phila Pa 1976) 13:1344-8. 1988
    ..another? This study was performed to investigate the changes in Substance P (SP) and Vasoactive-Intestinal Peptide (VIP), found in the dorsal root ganglion, following discography in normal and abnormal canine lumber intervertebral ..
  47. ncbi Direct suppression by beta-mercaptoethanol of the prolactin immunoreactivity within the cultured rat adenohypophyseal cells
    K Nakamura
    Second Department of Physiology, School of Medicine, Iwate Medical University, Japan
    Horm Metab Res 25:603-7. 1993
    ..effects were observed under basal condition, as well as during stimulation with vasoactive intestinal peptide (VIP). The minimum effective doses of ME ranged from 0.0001 to 0.01%...
  48. ncbi Concentrations and distribution of vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI) and peptide histidine valine (PHV) in the cerebral cortex and the suprachiasmatic nucleus of the mouse
    J D Mikkelsen
    Institute of Medical Anatomy B, University of Copenhagen, Panum Institute, Denmark
    Brain Res 656:95-107. 1994
    Prepro-vasoactive intestinal peptide (prepro-VIP) is processed to at least three biologically active peptides: VIP, peptide histidine isoleucine (PHI) and an extended PHI, peptide histidine valine (PHV)...
  49. ncbi Vasoactive intestinal peptide stimulates T lymphocytes to release IL-5 in murine schistosomiasis mansoni infection
    R C Mathew
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
    J Immunol 148:3572-7. 1992
    ..The granulomas have eosinophils that produce vasoactive intestinal peptide (VIP) and T cells that display VIP receptors...
  50. doi Vasoactive intestinal peptide (VIP) treatment of Parkinsonian rats increases thalamic gamma-aminobutyric acid (GABA) levels and alters the release of nerve growth factor (NGF) by mast cells
    Orhan Tansel Korkmaz
    Department of Physiology, Medical Faculty, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey
    J Mol Neurosci 41:278-87. 2010
    ..In a previous study, we found that systemically administered vasoactive intestinal peptide (VIP) was effective at reversing the motor deficits (but not the decline in striatal dopamine levels) in a rat model of ..
  51. ncbi Coronary vascular effects of vasoactive intestinal peptide in the isolated perfused rat heart
    Darrell R Sawmiller
    Department of Internal Medicine, University of South Florida Health Science Center, 12901 Bruce B Downs Blvd, MDC 19, Tampa, FL 33612 4799, USA
    Neuropeptides 38:289-97. 2004
    The potency and mechanism of action of vasoactive intestinal peptide (VIP) for producing coronary vasodilation was investigated in the isolated perfused heart of the rat...
  52. ncbi Excitatory actions of vasoactive intestinal peptide on mouse thalamocortical neurons are mediated by VPAC2 receptors
    Sang Hun Lee
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    J Neurophysiol 96:858-71. 2006
    ..Vasoactive intestinal peptide (VIP) is a neuropeptide localized within the thalamus and strongly attenuates intrathalamic rhythms via an unidentified ..
  53. pmc Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP
    A Ben Jebria
    Laboratoire de Physiologie, , , France
    Br J Pharmacol 109:131-6. 1993
    ..induced by the following neuropeptides substance P (SP), neurokinin A (NKA) and vasoactive intestinal peptide (VIP) was studied both in the absence and in the presence of the neutral endopeptidase (NEP) inhibitor, phosphoramidon...
  54. ncbi Mechanisms of vasoactive intestinal peptide-elicited coronary vasodilation in the isolated perfused rat heart
    Darrell R Sawmiller
    Department of Internal Medicine Cardiology, University of South Florida Health Science Center, Tampa, FL 33612 4799, USA
    Neuropeptides 40:349-55. 2006
    The present study investigated the potential role of vasoactive intestinal peptide (VIP) receptors, VPAC1 and VPAC2, in VIP-elicited coronary vasodilation of the isolated perfused rat heart...
  55. ncbi [Changes of vasoactive intestinal polypeptide and vasoactive intestinal polypeptide receptor 1 in small intestine and liver during macaque development]
    Mei Mei Guo
    Division of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy of Human Diseases, West China Hospital, Sichuan University, Chengdu, China
    Sheng Li Xue Bao 59:163-8. 2007
    The present study was aimed to investigate the changes of vasoactive intestinal polypeptide (VIP) and VIP receptor 1 (VIPR1) in small intestinal and hepatic tissues during macaque development...
  56. doi Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells
    Mario Delgado
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Arthritis Rheum 58:1010-9. 2008
    Vasoactive intestinal peptide (VIP) has been shown to be one of the endogenous factors involved in the maintenance of immune tolerance. Administration of VIP ameliorates clinical signs in various experimental autoimmune disorders...
  57. doi Involvement of vasoactive intestinal polypeptide in the parasympathetic vasodilatation of the rat masseter muscle
    Takeharu Niioka
    Division of Physiology, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Arch Oral Biol 54:909-16. 2009
    ..However, the non-cholinergic mechanisms are still unclear. Recently, vasoactive intestinal polypeptide (VIP) was convincingly shown to be involved in the parasympathetic vasodilatation in orofacial areas, such as ..
  58. ncbi Vasoactive intestinal peptide modulates luteinizing hormone subunit gene expression in the anterior pituitary in female rat
    Alina Gajewska
    Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Warsaw
    Brain Res Bull 67:319-26. 2005
    The direct monosynaptic pathway which exists between vasoactive intestinal peptide (VIP) and GnRH neurons in the hypothalamic preoptic area provides a neuroanatomical background for the modulatory effects of VIP exerted on GnRH neurons ..
  59. pmc Characterization of the rat vasoactive intestinal polypeptide receptor gene 5' region
    L Pei
    Division of Endocrinology, Cedars Sinai Medical Center UCLA School of Medicine 90048, USA
    Biochem J 308:719-23. 1995
    The broad spectrum of vasoactive intestinal polypeptide (VIP) cellular functions are mediated by high-affinity binding sites...
  60. pmc The role of joint nerves and mast cells in the alteration of vasoactive intestinal peptide (VIP) sensitivity during inflammation progression in rats
    Jason J McDougall
    Department of Physiology and Biophysics, University of Calgary, 3330, Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Br J Pharmacol 145:104-13. 2005
    The present study examined the peripheral effects of vasoactive intestinal peptide (VIP) on rat knee joint blood flow during acute and chronic inflammation...
  61. ncbi Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis
    Wei Sun
    Department of Neurology, Baylor College of Medicine, Mail station NB302, One Baylor Plaza, Houston, TX 77030, USA
    Int Immunol 18:1691-700. 2006
    Vasoactive intestinal peptide (VIP) has a unique property of regulating T(h)1 and T(h)2 immunity of CD4+ T cells...
  62. pmc Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi
    J W Wiley
    University of Michigan Medical Center, Department of Internal Medicine, Ann Arbor 48109
    J Clin Invest 81:1920-4. 1988
    ..the hypothesis that cholecystokinin (CCK) relaxes the sphincter of Oddi via vasoactive intestinal polypeptide (VIP). Isolated canine sphincter of Oddi were suspended in organ baths under standard conditions...
  63. pmc Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 10:875-80. 2004
    ..To study the alterations of brain-gut peptides following traumatic brain injury (TBI) and to explore the underlying significance of these peptides in the complicated gastrointestinal dysfunction...
  64. ncbi Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells
    M Lara-Marquez
    Children s Research Institute, Departments of Pediatrics, Molecular Immunology, Virology, and Human Genetics, and Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43205, USA
    J Immunol 166:2522-30. 2001
    Vasoactive intestinal peptide (VIP) has potent antiproliferative and anti-inflammatory functions in the immune system...
  65. pmc Significance of changes of gastrointestinal peptides in blood and ileum of experimental spleen deficiency rats
    Li Sheng Li
    Department of Physiology, Capital University of Medical Sciences, 100054, Beijing, China
    World J Gastroenterol 9:553-6. 2003
    ..To explore the mechanism of spleen deficiency (SD) by studying the relationship of gastro-intestinal peptides level and ileal electro-mechanical activity of SD rats and cold restrain rats...
  66. ncbi Vasoactive intestinal peptide modulates Langerhans cell immune function
    Sreedevi Kodali
    Department of Dermatology, Joan and Sanford I Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    J Immunol 173:6082-8. 2004
    ..The neuropeptide vasoactive intestinal peptide (VIP) has also been found in cutaneous nerves and mRNA, for the VIP receptor vasoactive intestinal peptide receptor type ..
  67. ncbi Vasoactive intestinal peptide receptor antagonists in rat seminal vesicle membranes
    M S Rodriguez-Pena
    Departamento de Bioquimica y Biologia Molecular, Universidad de Alcala, Alcala de Henares, Madrid, Spain
    Eur J Pharmacol 208:207-12. 1991
    Vasoactive intestinal peptide (VIP) receptors coupled to activation of adenylate cyclase have been previously identified in seminal vesicle membranes of rat...
  68. ncbi Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate
    R M Solano
    Department of Biochemistry and Molecular Biology, University of Alcala, Alcala de Henares, Spain
    Endocrinology 137:2815-22. 1996
    Vasoactive intestinal peptide (VIP) is an important member of the group of neuropeptides that appears to be involved in the regulation of prostatic growth and function...
  69. ncbi Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice
    Julia K Voice
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    J Immunol 170:308-14. 2003
    Vasoactive intestinal peptide (VIP) and its two G protein-coupled receptors, VPAC1 and VPAC2, are quantitatively prominent and functionally critical in the immune system...
  70. ncbi Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 10:8235-42. 2004
    Human tumors frequently overexpress receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP)...
  71. ncbi Expression localisation and functional activity of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide and their receptors in mouse ovary
    Marzia Barberi
    Department of Histology and Medical Embriology, La Sapienza University of Rome, Via A Scarpa, 14, Rome 00161, Italy
    Reproduction 134:281-92. 2007
    Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) positively affect several parameters correlated with the ovulatory process...
  72. ncbi PACAP-(6-38) inhibits the effects of vasoactive intestinal polypeptide, but not PACAP, on the small intestinal circular muscle
    Z Lazar
    Department of Pharmacology and Pharmacotherapy, University of Pecs, Szigeti u 12, H 7643 Pecs, Hungary
    Eur J Pharmacol 431:259-64. 2001
    Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating peptide-(1-38) (PACAP) have been found to stimulate distension-induced peristaltic motility in the guinea-pig isolated small intestine...
  73. ncbi Effect of vasoactive intestinal peptide on gastric adenocarcinoma
    Guo Hua Li
    Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
    J Gastroenterol Hepatol 22:1328-35. 2007
    Vasoactive intestinal peptide (VIP) is a gastrointestinal hormone in the secretin-VIP family. It has been reported that VIP affects some tumor growth, and there is a VIP autocrine regulation in some cancers...
  74. pmc Vasoactive intestinal polypeptide can excite gonadotropin-releasing hormone neurons in a manner dependent on estradiol and gated by time of day
    Catherine A Christian
    Neuroscience Graduate Program, Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 149:3130-6. 2008
    ..Vasoactive intestinal polypeptide (VIP) may be involved in suprachiasmatic nuclei-GnRH neuron communication...
  75. ncbi VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide in primary rat adipocytes
    Lina Akesson
    Section for Molecular Signaling, Department of Cell and Molecular Biology, Biomedical Center C11, Lund University, SE 221 84 Lund, Sweden
    Endocrinology 146:744-50. 2005
    The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) are structurally and functionally related...
  76. ncbi Functional expression of receptors for calcitonin gene-related peptide, calcitonin, and vasoactive intestinal peptide in the human thymus and thymomas from myasthenia gravis patients
    J Marie
    Institut National de la Sante et de la Recherche Medicale, Unit 482, Signalisation et Fonctions Cellulaires, Applications au Diabète et aux Cancers Digestifs, Hopital Saint Antoine, Paris, France
    J Immunol 162:2103-12. 1999
    The molecular and functional expression of serpentine membrane receptors for vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP), and calcitonin (CT) were characterized in human thymus and thymomas from myasthenia ..
  77. ncbi Androgens augment vasoactive intestinal peptide- and growth hormone-releasing hormone-stimulated progestin production by rat granulosa cells
    Y D Li
    Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242
    Endocrinology 132:584-90. 1993
    Vasoactive intestinal peptide (VIP) has been shown to stimulate steroid production by cultured rat granulosa cells independently of FSH. In the present study, we have examined the modulatory effects of various steroids on this response...
  78. pmc Effect of fluoxetine on depression-induced changes in the expression of vasoactive intestinal polypeptide and corticotrophin releasing factor in rat duodenum
    Yong Lan Huang
    Department of Mental Health Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 13:6060-5. 2007
    To investigate changes in vasoactive intestinal polypeptide (VIP) and corticotrophin releasing factor (CRF) in the plasma and duodenum of chronic stress-induced depressed rats and the effects of fluoxetine hydrochloride (fluoxetine) ..
  79. ncbi Immunohistochemical localization of vasoactive intestinal peptide (VIP) in the circumventricular organs of the rat
    J D Mikkelsen
    Institute of Medical Anatomy, University of Copenhagen, Denmark
    Cell Tissue Res 255:307-13. 1989
    ..immunohistochemical technique was used to investigate the possible presence of vasoactive intestinal peptide (VIP) in the circumventricular organs of the rat...
  80. ncbi Dual actions of S-nitrosylated derivative of vasoactive intestinal peptide as a vasoactive intestinal peptide-like mediator and a nitric oxide carrier
    L Jia
    VAMC, University of California, San Diego School of Medicine, 92161, USA
    Eur J Pharmacol 366:79-86. 1999
    Vasoactive intestinal peptide (VIP) has been postulated as a non-adrenergic non-cholinergic (NANC) transmitter in the relaxation of vascular and non-vascular systems...
  81. pmc Effects of vasoactive intestinal peptide, helodermin and galanin on responses of guinea-pig lung parenchyma to histamine, acetylcholine and leukotriene D4
    D M Conroy
    Department of Pharmacology, Hunterian Institute, Royal College of Surgeons, London
    Br J Pharmacol 104:1012-8. 1991
    1. The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (..
  82. pmc Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung
    G Ciabattoni
    Department of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Br J Pharmacol 109:243-50. 1993
    1. Exogenous vasoactive intestinal polypeptide (VIP) infused into the pulmonary artery of isolated and ventilated lungs of guinea-pigs decreased, in a dose-dependent fashion (1.0-10...
  83. ncbi Receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in turkey cerebral cortex: characterization by [125I]-VIP binding and effects on cyclic AMP synthesis
    Jolanta B Zawilska
    Department of Pharmacodynamics, Medical University of Lodz, 1 Muszynskiego St, 90 151 Lodz, Poland
    Gen Comp Endocrinol 137:187-95. 2004
    Receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in turkey cerebral cortex were characterized using two approaches: (1) in vitro radioreceptor binding of [125I]-VIP, and (2) ..
  84. ncbi Participation of vasoactive intestinal polypeptide in ovarian steroids production during the rat estrous cycle and in the development of estradiol valerate-induced polycystic ovary
    Claudio Parra
    Lab Neurobioquímica, Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    Reproduction 133:147-54. 2007
    Vasoactive intestinal polypeptide (VIP) stimulates estradiol and progesterone release from ovarian granulosa cells in vitro...
  85. ncbi Role of the vasoactive intestinal peptide in a neuroendocrine regulation of the adrenal cortex
    M Ehrhart-Bornstein
    Institute for Medical Physiology C, University of Copenhagen, Denmark
    Neuroendocrinology 54:623-8. 1991
    ..nerve supply, we measured the release of cortisol and aldosterone and of the vasoactive intestinal peptide (VIP) after electrical stimulation of the splanchnic nerves...
  86. pmc Regional haemodynamic responses to pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide in conscious rats
    S M Gardiner
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 111:589-97. 1994
    ..peptides, pituitary adenylate cyclase-activating peptide (1-27) (PACAP27) and vasoactive intestinal polypeptide (VIP) were assessed by giving 20 min infusions (1...
  87. pmc Interplay between nitric oxide and vasoactive intestinal polypeptide in inducing fluid secretion in rat jejunum
    F H Mourad
    Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Lebanon
    J Physiol 550:863-71. 2003
    Nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) interact in the regulation of neuromuscular function in the gut. They are also potent intestinal secretogogues that coexist in the enteric nervous system...
  88. ncbi Ganglion cells immunoreactive for catecholamine-synthesizing enzymes, neuropeptide Y and vasoactive intestinal polypeptide in the rat adrenal gland
    Y Oomori
    Department of Anatomy, Asahikawa Medical College, Japan
    Cell Tissue Res 275:201-13. 1994
    ..DBH), phenylethanolamine N-methyltransferase (PNMT), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP) immunoreactivities, and acetylcholinesterase (AChE) activity was demonstrated in rat adrenal glands...
  89. ncbi Influence of 4-day long treatment with vasoactive intestinal peptide on ultrastructure and function of the rat pinealocytes in organ culture
    Marcin Nowicki
    Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
    Folia Histochem Cytobiol 40:9-16. 2002
    Vasoactive intestinal peptide (VIP) is one of neuropeptides involved in the regulation of the pineal gland function. The acute treatment of rat pinealocytes with VIP caused changes in their biochemical parameters...
  90. ncbi Cross-talk between cellular signaling pathways activated by substance P and vasoactive intestinal peptide in rat lactotroph-enriched pituitary cell cultures
    S E Mau
    Department of Medical Physiology, University of Copenhagen, Denmark
    Endocrinology 138:1704-11. 1997
    ..C (PKC)/inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) messenger systems probed by vasoactive intestinal peptide (VIP) and substance P (SP), respectively, in rat pituitary cell cultures enriched in lactotrophs...
  91. ncbi Injection therapy for the treatment of erectile dysfunction: a comparison between alprostadil and a combination of vasoactive intestinal polypeptide and phentolamine mesilate
    P J R Shah
    Institute of Urology and Nephrology, London, UK
    Curr Med Res Opin 23:2577-83. 2007
    To compare two injectable treatments, alprostadil 5-20 microg powder for injection and a combination of vasoactive intestinal polypeptide (VIP) and phentolamine in patients with erectile dysfunction (ED).
  92. ncbi [Vasoactive intestinal peptide expression and its clinical significance in gastric adenocarcinoma]
    Hui Chen
    Department of Digestion Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 22:452-4. 2008
    To investigate the expression of vasoactive intestinal peptide (VIP) in gastric adenocarcinoma, and to evaluate the correlation of VIP level with clinical pathologic parameters.
  93. ncbi Experimental lumbar radiculopathy. Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat
    M Kawakami
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 19:1780-94. 1994
    ..a consistent trend toward baseline and return to baseline by 12 weeks; significantly greater and highly increased VIP concentrations in the dorsal root ganglia 2 weeks postoperatively (P < ...
  94. pmc Neural, hormonal, and paracrine regulation of gastrin and acid secretion
    M L Schubert
    Department of Medicine, Medical College of Virginia, Richmond 23298-0711
    Yale J Biol Med 65:553-60; discussion 621-3. 1992
    ..The effector neurons comprise cholinergic neurons and two types of non-cholinergic neurons: bombesin/GRP and VIP neurons...
  95. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
    ..Initially, HDCT was given as consolidation of third line VIP (etoposide/ifosfamide and cisplatin), following failure of a weekly cisplatin regimen...
  96. ncbi Clinical features of carcinoid syndrome and the use of somatostatin analogue in its management
    A I Vinik
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109
    Acta Oncol 28:389-402. 1989
    ..In individual instances the tumor may even infarct, leading to spontaneous cure. Tumors secreting PP, ACTH and calcitonin may be particularly resistant to treatment, whereas VIP secreting tumors appear to be sensitive.
  97. ncbi Peptidergic (VIP) nerves in normal human pancreas and in pancreatitis: an immunohistochemical study
    L Marongiu
    Department of Cytomorphology, University of Cagliari, Italy
    Histol Histopathol 8:127-32. 1993
    ..In specimens from patients affected by pancreatitis, even in lesioned regions, immunoreactive elements were extremely scarce...
  98. ncbi Diurnal variations in vasoactive intestinal polypeptide-like immunoreactivity in the suprachiasmatic nucleus of congenitally anophthalmic mice
    L K Laemle
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Brain Res 688:203-8. 1995
    ..of circadian locomotor rhythms with light microscopic immunocytochemistry for vasoactive intestinal polypeptide (VIP) in the suprachiasmatic nucleus (SCN) of congenitally anophthalmic mice...
  99. ncbi Distribution of intrinsic cardiac neurons in whole-mount guinea pig atria identified by multiple neurochemical coding. A confocal microscope study
    M Horackova
    Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Cell Tissue Res 297:409-21. 1999
    ..ChAT) immunoreactivity (IR), tyrosine hydroxylase (TH) IR, neuropeptide Y (NPY) IR, vasoactive peptide (VIP) IR and substance P (SP) IR. The remaining 5% of ganglionic neurons were small (group 1c; less than 20 microm)...
  100. ncbi Pheochromocytoma and sub-clinical Cushing's syndrome during pregnancy: diagnosis, medical pre-treatment and cure by laparoscopic unilateral adrenalectomy
    G Finkenstedt
    Department of Internal Medicine, University of Innsbruck, Austria
    J Endocrinol Invest 22:551-7. 1999
    ..immunostaining for interleukin-6 (IL-6) and negative immunostaining for ACTH, vasoactive intestinal polypeptide (VIP) and cytochrome P450, and with no signs of malignancy...
  101. ncbi Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle
    A Kawabata
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Life Sci 67:2521-30. 2000
    ..The relaxation was resistant to antagonists of PACAP receptors, VIP receptors and P2 purinoceptors...

Research Grants62

  1. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..In this proposal we will determine the influence of these specific neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical circuits...
  2. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..In this proposal we will determine the influence of these neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical circuits...
  3. CELLULAR BASIS OF CIRCADIAN RHYTHMS IN MAMMALS
    ERIK HERZOG; Fiscal Year: 2013
    ..The neuropeptide vasoactive intestinal polypeptide (VIP) is required for circadian synchrony in the SCN and is found in neurons of other circadian tissues...
  4. VIP--A MEDIATOR OF NEUROIMMUNE INTERACTIONS
    Doina Ganea; Fiscal Year: 2000
    ..as substance P stimulate immune functions, whereas other neuropeptides such as the vasoactive intestinal peptide (VIP) exert primarily an anti-inflammatory action...
  5. ALTERATION WITH AGE OF RESISTANCE TO EYE INFECTIONS
    Linda D Hazlett; Fiscal Year: 2013
    ..inflammatory neuropeptide, Substance P (SP) and the anti-inflammatory neuropeptide, vasoactive intestinal peptide (VIP) in regulation of inflammation, innate immunity and restoration of corneal homeostasis...
  6. DEBTIRTHO DIPON GHOSH; Fiscal Year: 2015
    ..While PDF and its homolog Vasoactive Intestinal Peptide (VIP) mediate the circadian clock in insects and mammals, respectively, PDF function in worms is unclear...
  7. The role of VIP in the Circadian Regulation of Cardiovascular Rhythms
    ANALYNE M SCHROEDER; Fiscal Year: 2011
    ..The neuropeptide, Vasoactive Intestinal Peptide (VIP), is expressed in the SCN and is implicated in coordinating cellular oscillators...
  8. Doina Ganea; Fiscal Year: 2014
    ..that dendritic cells (DC) differentiated in the presence of the neuropeptide vasoactive intestinal peptide (VIP) become tolerogenic, and induce regulatory T cells (Treg)...
  9. Eosinophil trafficking in fungal allergic asthma
    Glenn Paul Dorsam; Fiscal Year: 2013
    ..trafficking of eosinophils in the lung lumen to signaling by a neuropeptide called vasoactive intestinal peptide (VIP)...
  10. Vasoactive intestinal peptide for the treatment of psoriasis
    Sandra Reichstetter; Fiscal Year: 2013
    ..We are proposing to formulate the immunomodulatory neuropeptide vasoactive intestinal peptide (VIP) into a long-acting formulation that will be tested as a drug candidate for the treatment of psoriasis...
  11. Phospholipid Nanocarriers Improve Chemotherapy by Targeted Drug Delivery
    Hayat Onyuksel; Fiscal Year: 2010
    ..the attributes of sterically stabilized mixed micelles (SSMM) with surface-grafted vasoactive intestinal peptide (VIP). SSMM are composed of a polyethylene glycol (PEG) conjugated phospholipid and phosphatidylcholine...
  12. VIP AND EGF RECEPTORS IN NON-SMALL CELL LUNG CANCER
    Terry Moody; Fiscal Year: 1991
    ..Recently, we observed that vasoactive intestinal polypeptide (VIP) binds with high affinity to NSCLC cell lines as well as SCLC...
  13. NEUROPEPTIDE RECEPTORS IN OCULAR AND PERIPHERAL TISSUES
    Steven Rosenzweig; Fiscal Year: 1992
    ..of this proposal is to analyze the structure and function of the receptors for vasoactive intestinal peptide (VIP) and insulin in retinal and hepatic membranes...
  14. IMMUNE EFFECTOR VASOACTIVE INTESTINAL PEPTIDE RECEPTORS
    M O DORISIO; Fiscal Year: 1991
    ..Vasoactive intestinal peptide (VIP) is a 28 amino acid neuromodulator found in high concentrations in both central and peripheral nervous tissue; ..
  15. NEUROCHEMISTRY OF GESTATION-PRODUCED ANALGESIA
    Alan R Gintzler; Fiscal Year: 2010
    ..facilitation of enk release by DOR is triggered by increased release of spinal vasoactive intestinal polypeptide (VIP) from varicosities that appose Dyn neurons...
  16. VIP, VIP RECEPTORS AND THE INTESTINAL EPITHELIAL CELL
    Toan Nguyen; Fiscal Year: 1992
    The effects of vasoactive intestinal peptide (VIP) on intestinal secretion have been well characterized...
  17. CHARACTERIZATION OF THE VIP RECEPTOR IN THE LUNG
    Sudhir Paul; Fiscal Year: 1992
    The objectives are: (1) To solubilize functional receptors for vasoactive intestinal peptide (VIP) from the lung; (2) To raise monoclonal anti-receptor antibody; (3) To purify the receptor and analyze its structure; (4) To demonstrate ..
  18. REGULATION OF THE RAT VIP RECEPTOR GENE
    Lin Pei; Fiscal Year: 2000
    Vasoactive intestinal peptide (VIP) is a 28 amino acid polypeptide with a broad spectrum of biological functions. The effects of VIP are mediated by high affinity receptors...
  19. NEUROENDOCRINE CONTROL OF SMALL INTESTINAL MOTILITY
    Thomas Nowak; Fiscal Year: 1990
    ..field stimulation and the fluid bathing each segment is removed and assayed for vasoactive intestinal polypeptide (VIP), motilin, cholecystokinin, (CCK) and substance P...
  20. Lorenzo Cohen; Fiscal Year: 2015
    ..as well as levels of total protein, calcitonin- gene-related peptide (CGRP), and vasoactive intestinal polypeptide (VIP);and 6. Examine the role of expectancy for the benefits of acupuncture in predicting outcomes...
  21. NEUROPEPTIDES AND CARCADIAN RHYTHMS DURING AGING
    Phyllis Wise; Fiscal Year: 2000
    ..Vasoactive intestinal peptide (VIP) and somatostatin (SRIF) may play key roles as communicators of differential afferent input, broadcasters of ..
  22. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..changes in neuroendocrine function, hypothalamic expression of vasopressin, vasoactive intestinal polypeptide (VIP), and serotonin function have also been reported in humans...
  23. Long-acting VIP formulations for the treatment of chronic inflammatory diseases
    Sandra Reichstetter; Fiscal Year: 2010
    ..Vasoactive intestinal peptide (VIP) is an immunomodulatory peptide that induces regulatory T-cells and anti-inflammatory cytokine responses and has ..
  24. Marcy A Kingsbury; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Vasoactive intestinal polypeptide (VIP) is a major regulator of prolactin secretion in vertebrates, and is thus an essential contributor to the central regulation of parental care, even if only via ..
  25. ANDREW JASON GLOWACKI; Fiscal Year: 2015
    ..Specific Aim III: Examination of VIP as a potential mediator of CCL-22 secretion by native cells...
  26. Corneal endothelial cell survival in human donor corneas for transplantation
    Shay Whey M Koh; Fiscal Year: 2012
    ..Previously, We have reported how a CE autocrine trophic factor, the 28 amino-acid vasoactive intestinal peptide (VIP) maintains the differentiated state of the corneal endothelium, including CE cell size, shape, and retention, in ..
  27. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..Although neuropeptides such as vasoactive intestinal polypeptide (VIP) and cholecystokinin (CCK) have been shown to influence neuromuscular transmission, the role of endocrine factors ..
  28. 8th International Symposium for VIP, PACAP & Related Peptides
    Victor May; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The 8th International Symposium on VIP, PACAP, and Related Peptides is planned for September 3 - 8, 2007 at The Equinox Spa and Resort in Manchester, Vermont...
  29. Adam Kepecs; Fiscal Year: 2015
    ..classes of interneurons: the parvalbumin (PV), somatostain (SOM), and vasoactive intestinal peptide (VIP) positive cells using knock-in Cre-driver lines, each with distinct functions...
  30. FUNCTION OF AMACRINE CELLS IN MAMMALIAN RETINA
    Ralph Jensen; Fiscal Year: 1991
    ..specific aims of this project are: (1) to understand the role the neurotransmitter vasoactive intestinal peptide (VIP) plays in the formation of the receptive fields of ganglion cells; (2) to study the functional relationship of VIP-..
  31. REGULATION OF IMMUNITY TO HERPES SIMPLEX VIRUS
    John Sheridan; Fiscal Year: 1990
    ..Experimental studies have also demonstrated that neuropeptides (NP) such as vasoactive intestinal peptide (VIP), somatostatin (SOM), substance P (SP), gastrin-releasing peptide (GRP) can affect lymphocyte proliferation and ..
  32. VIP AND NO IN AIRWAY INFLAMMATION AND ASTHMA
    SAMI SAID; Fiscal Year: 2000
    ..The proposal will test the following specific hypotheses regarding two transmitters, vasoactive intestinal peptide (VIP) and nitric oxide (NO): 1) As cotransmitters of non-adrenergic, non-cholinergic relaxation, VIP and NO modulate the ..
  33. Multiscale Modeling & Analysis of Circadian Rhythm Generation & Synchronization
    Linda Petzold; Fiscal Year: 2009
    ..the coupling of individual pacemaker neurons is mediated by the neurotransmitter vasoactive intestinal peptide (VIP) prevalent in the suprachiasmatic nucleus (SCN)...
  34. NO AND VIP IN GASTRIC MOTILITY USING KNOCKOUT MICE
    Hiroshi Mashimo; Fiscal Year: 1999
    ..proposal uses mice with gene-targeted disruption of nitric oxide synthases (NOS) and vasoactive intestinal peptide (VIP) to understand their inhibitory role in gut neurotransmission and motility...
  35. CYTOKINE REGULATION OF VIP GENE EXPRESSION
    Aviva Symes; Fiscal Year: 2002
    ..CNTF and LIF induce expression of the gene that encodes the neuropeptide, vasoactive intestinal peptide (VIP), through a 180bp cytokine response element (CyRE) in the VIP promoter...
  36. Modulation of Lung Inflammation and Cell Death by VIP
    SAMI SAID; Fiscal Year: 2006
    ..mechanisms are a major pathogenic factor in cell death due to oxidant stress; and 3) Vasoactive intestinal peptide (VIP) and the related pituitary adenylate cyclase activating peptide (PACAP) can effectively reduce or prevent at least ..
  37. ECTOPIC HORMONE SYNTHESIS IN PHEOCHROMOCYTOMA CELLS
    Richard Goodman; Fiscal Year: 1991
    ..Expression of vasoactive intestinal polypeptide (VIP) in pheochromocytoma and neuroblastoma cells is regulated by cAMP and protein kinase C-dependent pathways...
  38. IMAGING COLORECTAL CANCER WITH TC 99M VIP
    Mathew Thakur; Fiscal Year: 1999
    ..Evidence is abundant in the literature that vasoactive intestinal peptide (VIP) receptors are expressed in high density on colorectal cancer cells and that the tumors and their metastatic ..
  39. GABAA RECEPTOR FUNCTION AND SUBUNIT EXPRESSION
    HERMES YEH; Fiscal Year: 1999
    ..the mechanism(s) by which the postsynaptic GABAA receptor may be modified by vasoactive intestinal polypeptide (VIP) in the retina and by norepinephrine (NE) in the cerebellum...
  40. NEUROENDOCRINE AND NEUROCHEMICAL FUNCTION DURING AGING
    Phyllis Wise; Fiscal Year: 1999
    ..Attention will be focused on vasoactive intestinal peptide (VIP), its major afferent input, serotonin (5HT), and a major efferent target, GnRH...
  41. Peptidergic regulation of photic signaling within the SCN
    ANDREW MARTIN VOSKO; Fiscal Year: 2010
    ..One such neuropeptide, vasoactive intestinal peptide (VIP), appears to modulate light responses in the master circadian pacemaker of mammals, the suprachiasmatic nucleus (..
  42. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..g. GABA, dopamine, serotonin, acetylcholine) or neuropeptide (e.g. galanin, NPY, VIP, substance P) phenotype...
  43. Paul H Taghert; Fiscal Year: 2016
    ..PDF-R is a Class B peptide GPCR - that category includes receptors for the mammalian PACAP and VIP peptides. We will pursue two specific aims related to PDF receptor signaling...
  44. Valentina Sabino; Fiscal Year: 2016
    ..the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon/VIP superfamily, and a pleiotropic molecule with remarkable central actions on neuroendocrine and behavioral systems...
  45. RECEPTOR INTERACTIONS IN CILIARY PROCESSES
    LARRY BAUSHER; Fiscal Year: 1993
    ..Toward this end we propose to study interactions among beta2-, alpha2-, VIP, ANF, and somatostatin receptors in regulating cyclic nucleotide production by ciliary processes and examine the ..
  46. Patrick Emery; Fiscal Year: 2015
    ..and Drosophila, while the PDF/PDFR signaling pathway is the functional and molecular homolog of the mammalian VIP/VIPR pathway, which synchronizes circadian neurons in the suprachiasmatic nucleus...
  47. VIP RECEPTOR SECOND MESSENGERS IN PANCREATIC CANCER
    CHARLES ULRICH; Fiscal Year: 2002
    ..PRELIMINARY STUDIES in our laboratory support the UNIFYING HYPOTHESIS that VIP-1 receptors are commonly expressed in human ductal pancreatic adenocarcinomas and couple to opposing pathways with ..
  48. NEURAL MECHANISMS RESETTING THE AGED CIRCADIAN PACEMAKER
    Marilyn J Duncan; Fiscal Year: 2010
    ..In the SCN, aging increases serotonin transporter sites and decreases VIP mRNA expression...
  49. VIP RECEPTOR IN THE RETINAL PIGMENT EPITHELIUM
    Shay Whey Koh; Fiscal Year: 1991
    ..Among the modulators of the cyclic AMP pools of the RPE, the vasocative intestinal peptide (VIP) is the most effective one...
  50. VIP Receptor Distribution and GABA Receptor Interactions
    Scott Lilly; Fiscal Year: 2006
    Although substantial evidence exists for the activity-dependent release of VIP in the CNS, its effect on synaptic function is poorly described...
  51. REGULATION OF THE RAT VIP RECEPTOR GENE
    Lin Pei; Fiscal Year: 1999
    Research: The broad spectrum of VIP biological functions are mediated by its receptor. In the lung, VIP acts as a potent smooth muscle relaxant and it may also regulate lung cancer proliferation...
  52. CHARACTERIZATION OF VIP RECEPTORS & VIP AUTOANTIBODIES
    Sudhir Paul; Fiscal Year: 1993
    ..The immediate objectives are: 1) To solublize functional receptors for VIP from lung; (2) To raise anti-receptor antibody; (3) To purify the receptor and analyze its structure; (4) To ..
  53. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..1) contracted and generated sustained force in response to acetylcholine and PdBU;and 2) relaxed in response to VIP and Electrical Filed Stimulation (EFS)...
  54. OVARIAN HORMONE REGULATION OF LHRH BIOSYNTHESIS
    Sandra L Petersen; Fiscal Year: 2010
    ..vesicular glutamate transporter in dual-phenotype terminals contacting LHRH neurons;5) We will determine whether VIP stimulates cAMP-dependent NT gene expression through ligand-independent activation of PR on the afternoon of the LH ..
  55. PURINERGIC REGULATION OF ENTERIC NEURAL REFLEXES
    FEDIAS LEONTIOU CHRISTOFI; Fiscal Year: 2011
    ..A3 modulation in the inhibitory motor limb of reflex is determined by experiments on CM relaxation, VIP release, strain-gauge recording of large amplitude contractions or peristaltic propulsion of a fecal pellet...
  56. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony L Yaksh; Fiscal Year: 2012
    ..Acute activation of spinal P38 MAPK by tissue injury results from release of afferent transmitters (glutamate, SP, VIP), ATP and chemokines released from neurons and non-neurons, and circulating products released by inflammation (IPS)...
  57. Cognitive functions of multisensory cortical maps
    MARTIN IRENAEUS SERENO; Fiscal Year: 2013
    ..Studies in several areas in non-human primates including the ventral intraparietal area (VIP), area 7b, and the precentral polysensory zone (PZ) have shown that they contain multisensory neurons...
  58. MULTISENSORY INTEGRATION IN EXTRASTRIATE VISUAL CORTEX
    Dora Angelaki; Fiscal Year: 2012
    ..hypotheses regarding a role of the dorsal medial superior temporal area (MSTd) and ventral intraparietal area (VIP) in visual/vestibular cue integration...
  59. David McCormick; Fiscal Year: 2016
    ..cell types (Pyramidal and Stellate) and several inhibitory neuronal subtypes (PV/FS, SOM, NPY, 5HT3a, CR, VIP)...
  60. Contributions of Areas LIP and VIP to Numerical Behavior
    Michael L Platt; Fiscal Year: 2012
    ..Single neurons in the primate ventral intraparietal area (VIP), as well as in prefrontal cortex (dlPFC), respond selectively to a specific number of elements in a visual array...
  61. Kenneth H Britten; Fiscal Year: 2016
    ..system" in dorsal extrastriate cortex: the medial superior temporal area (MST) and the ventral intraparietal area (VIP)...
  62. NISHA INDRAVADAN PARIKH; Fiscal Year: 2014
    ..pressure, oral glucose tolerance test and lipid profile, in the V[unreadable]sterbotten Intervention Programme (VIP) when linked to the Swedish Population Registers (estimated n=16,041). 2...