VENTX

Summary

Gene Symbol: VENTX
Description: VENT homeobox
Alias: HPX42B, NA88A, VENTX2, homeobox protein VENTX, VENT homeobox homolog, VENT-like homeobox 2, VENT-like homeobox protein 2, hemopoietic progenitor homeobox protein VENTX2
Species: human

Top Publications

  1. pmc VentX trans-activates p53 and p16ink4a to regulate cellular senescence
    Xiaoming Wu
    Gastroenterology Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 286:12693-701. 2011
  2. pmc A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma
    A Moreau-Aubry
    Institut National de la Santé et de la Recherche Médicale INSERM U463, 44093 Nantes Cedex 01, France
    J Exp Med 191:1617-24. 2000
  3. pmc Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells
    Xiaoming Wu
    From the Departments of Medicine, Gastroenterology Division and
    J Biol Chem 289:14633-43. 2014
  4. pmc Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula
    Yi Ding
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Dev Biol . 2016
  5. pmc Homeobox protein VentX induces p53-independent apoptosis in cancer cells
    Hong Gao
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Oncotarget 7:39719-39729. 2016
  6. doi Immune complexome analysis reveals the specific and frequent presence of immune complex antigens in lung cancer patients: A pilot study
    Kaname Ohyama
    Course of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Int J Cancer 140:370-380. 2017
  7. pmc GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes
    Kambis Sadeghi
    Dept of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care and Neuropaediatrics, Medical University of Vienna, Vienna, Austria
    PLoS ONE 11:e0162667. 2016
  8. pmc VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice
    Eva Gentner
    Institute of Experimental Cancer Research, CCC and University Hospital of Ulm, 89081 Ulm, Germany
    Oncotarget 7:86889-86901. 2016
  9. pmc Ventx factors function as Nanog-like guardians of developmental potential in Xenopus
    Pierluigi Scerbo
    Departement Regulations, Developpement et Diversite Moleculaire, Museum national d histoire naturelle, Paris, France
    PLoS ONE 7:e36855. 2012
  10. pmc Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells
    Hong Gao
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 287:29979-87. 2012

Scientific Experts

  • Peter W H Holland
  • Hong Gao
  • Xiaoming Wu
  • Zhenglun Zhu
  • Vijay P S Rawat
  • Kaname Ohyama
  • Kambis Sadeghi
  • Eva Gentner
  • Yi Ding
  • Christian Buske
  • Michaela Feuring-Buske
  • Yi Le
  • Medhanie A Mulaw
  • Pierluigi Scerbo
  • Weixiong Ke
  • Leslie E Silberstein
  • Roger W Giese
  • Claudio N Gilardelli
  • Nozomi Aibara
  • Anil K Chauhan
  • Hideki Sakai
  • Naoya Kishikawa
  • Yoichi Nakamura
  • Haruka Yoshimi
  • Fumihiko Fujita
  • Yasuyoshi Miyata
  • Naotaka Kuroda
  • Yoshitaka Imaizumi
  • Konstanze Dohner
  • Simone Schuller
  • Hartmut Dohner
  • Eric A Sosa
  • Elisabeth Forster-Waldl
  • Susanne C Diesner
  • Yuki Moriyama
  • Kelvin Zhang
  • Naidu M Vegi
  • Lukas Wisgrill
  • Tamoghna Mandal
  • Bin Wu
  • Celia Dürr
  • Arnold Pollak
  • Gabriele Colozza
  • Alexander Grunenberg
  • Armando Heinle
  • Rainer Claus
  • Andreas Spittler
  • Shiva Bamezai
  • Maria D J Benitez
  • Lars Bullinger
  • Alpaslan Tasdogan
  • Diego Ploper
  • Leticia Quintanilla-Martinez
  • Torsten Haferlach
  • Isabelle Wessely
  • Monika Sachet
  • Edward M De Robertis
  • Ronald Bleday
  • Laurent Kodjabachian
  • Shuanhu Zhou
  • Yan Sun
  • Céline Vivien
  • Barbara Demeneix
  • Gabriel V Markov
  • Fabrice Girardot
  • Laurent Coen
  • Guillaume Luxardi
  • P A Moretti
  • Sheng Xiao
  • Martin Hager
  • Michael R Freeman
  • A Moreau-Aubry
  • Farid Ahmed
  • Bernhard Heilmeier
  • Tim Sadlon
  • Natalia Arseni
  • Silvia Thoene
  • RICHARD J D'ANDREA
  • Stefan K Bohlander
  • Wolfgang Hiddemann
  • Ombretta Pozzoli
  • Franco Cotelli
  • Paolo Sordino
  • Giorgio Matassi
  • E Baker
  • A J Davidson
  • L I Zon
  • R J D'Andrea
  • B Lilley
  • N Labarriere

Detail Information

Publications16

  1. pmc VentX trans-activates p53 and p16ink4a to regulate cellular senescence
    Xiaoming Wu
    Gastroenterology Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 286:12693-701. 2011
    ..Using methods of reverse genetics, we recently identified VentX, a human homolog of the vertebrate Xenopus Vent family of homeobox genes, as a novel Wnt repressor and a putative ..
  2. pmc A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma
    A Moreau-Aubry
    Institut National de la Santé et de la Recherche Médicale INSERM U463, 44093 Nantes Cedex 01, France
    J Exp Med 191:1617-24. 2000
    ..sequence identified it is a processed pseudogene, derived from a retrotranscript of mRNA coding for homeoprotein HPX42B. The NA88-A gene exhibits several premature stop codons, deletions, and insertions relative to the HPX42B gene...
  3. pmc Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells
    Xiaoming Wu
    From the Departments of Medicine, Gastroenterology Division and
    J Biol Chem 289:14633-43. 2014
    ..The molecular determinants of DC differentiation and maturation are target of extensive investigation. VentX is a human homeobox transcriptional factor that regulates proliferation and differentiation of hematopoietic cells...
  4. pmc Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula
    Yi Ding
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Dev Biol . 2016
    ..uncovered classical dorsal genes such as Chordin, Noggin and Cerberus, as well as ventral genes such as Sizzled, Ventx, Wnt8 and Bambi...
  5. pmc Homeobox protein VentX induces p53-independent apoptosis in cancer cells
    Hong Gao
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Oncotarget 7:39719-39729. 2016
    Identifying novel tumor suppressors holds promise for improving cancer treatment. Our recent studies identified VentX, a homeobox transcriptional factor, as a putative tumor suppressor...
  6. doi Immune complexome analysis reveals the specific and frequent presence of immune complex antigens in lung cancer patients: A pilot study
    Kaname Ohyama
    Course of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Int J Cancer 140:370-380. 2017
    ..heavy chains were specifically and frequently detected (at a frequency higher than 80%), and that phosphoproteins (VENTX, VCIP135) were also specifically present in the ICs of lung cancer patients...
  7. pmc GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes
    Kambis Sadeghi
    Dept of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care and Neuropaediatrics, Medical University of Vienna, Vienna, Austria
    PLoS ONE 11:e0162667. 2016
    ..Knockdown experiments of the transcription factors PU.1 and VentX showed that GM-CSF driven effects on TLR regulation is entirely PU.1 but not VentX dependent...
  8. pmc VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice
    Eva Gentner
    Institute of Experimental Cancer Research, CCC and University Hospital of Ulm, 89081 Ulm, Germany
    Oncotarget 7:86889-86901. 2016
    Homeobox genes are key regulators in normal and malignant hematopoiesis. The human Vent-like homeobox gene VENTX, a putative homolog of the Xenopus laevis Xvent-2 gene, was shown to be highly expressed in normal myeloid cells and in ..
  9. pmc Ventx factors function as Nanog-like guardians of developmental potential in Xenopus
    Pierluigi Scerbo
    Departement Regulations, Developpement et Diversite Moleculaire, Museum national d histoire naturelle, Paris, France
    PLoS ONE 7:e36855. 2012
    ..Joint over-expression of Xenopus ventx1.2 and ventx2.1-b (ventx1/2) counteracts lineage commitment towards both dorsal and ventral fates and prevents msx1-induced ..
  10. pmc Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells
    Hong Gao
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 287:29979-87. 2012
    ..Nevertheless, expansion of human HSC/MPPs for clinical application remains a critical challenge. VentX is a human homeobox transcription factor that was recently identified as an anti-proliferation and pro-..
  11. ncbi Molecular cloning of a human Vent-like homeobox gene
    P A Moretti
    Human Immunology Division and Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000, Australia
    Genomics 76:21-9. 2001
    We have isolated a previously unknown human homeobox-containing cDNA, VENT-like homeobox-2 (VENTX2), using PCR with a bone marrow cDNA library and primers designed from the VENTX1 (alias HPX42) homeobox sequence...
  12. ncbi Functional and hierarchical interactions among zebrafish vox/vent homeobox genes
    Claudio N Gilardelli
    Department of Biology, University of Milan, Milan, Italy
    Dev Dyn 230:494-508. 2004
    ..This inhibitory role is emphasized by a vox and vent redundant activity, compared with single gene effects...
  13. pmc Classification and nomenclature of all human homeobox genes
    Peter W H Holland
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    BMC Biol 5:47. 2007
    ..Increasingly, homeobox genes are being compared between genomes in an attempt to understand the evolution of animal development. Despite their importance, the full diversity of human homeobox genes has not previously been described...
  14. doi VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor
    Hong Gao
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 70:202-11. 2010
    ..Here, we report that VentX, a human Xom homologue, is a LEF/TCF-associated inhibitor of canonical Wnt/beta-catenin signaling and a negative ..
  15. pmc The vent-like homeobox gene VENTX promotes human myeloid differentiation and is highly expressed in acute myeloid leukemia
    Vijay P S Rawat
    Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm and University Hospital Ulm, 89081 Ulm, Germany
    Proc Natl Acad Sci U S A 107:16946-51. 2010
    ..Here we report that the human Vent-like homeobox gene VENTX, a putative homolog of the Xenopus xvent2 gene, is a unique regulatory hematopoietic gene that is aberrantly ..
  16. pmc The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
    Xiaoming Wu
    Department of Medicine, Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2599-613. 2011
    ..Here we report that the homeobox transcription factor VentX plays a pivotal role in human macrophage terminal differentiation and proinflammatory function...