VEGFR-2

Summary

Gene Symbol: VEGFR-2
Description: kinase insert domain receptor
Alias: CD309, FLK1, VEGFR, VEGFR2, vascular endothelial growth factor receptor 2, fetal liver kinase-1, kinase insert domain receptor (a type III receptor tyrosine kinase), protein-tyrosine kinase receptor Flk-1, soluble VEGFR2, tyrosine kinase growth factor receptor
Species: human

Top Publications

  1. pmc Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways
    Yan Xiong
    Laboratory of Vascular Biology, Institute of Molecular Medicine, Peking University, Beijing 10087, China
    J Biol Chem 284:23217-24. 2009
  2. doi Vascular endothelial growth factor and its high-affinity receptor (VEGFR-2) are highly expressed in the human forebrain and cerebellum during development
    Loïc Sentilhes
    Neovasc, Rouen Institute for Medical Research and Innovation, Normandy, France
    J Neuropathol Exp Neurol 69:111-28. 2010
  3. doi Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4340, USA
    Dev Cell 14:25-36. 2008
  4. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
  5. pmc HIV-1 upregulates VEGF in podocytes
    Sonal Navin Korgaonkar
    Department of, New York, Mount Sinai School of Medicine, New York, USA
    J Am Soc Nephrol 19:877-83. 2008
  6. doi Increased risk of ovarian hyperstimulation syndrome following controlled ovarian hyperstimulation in patients with vascular endothelial growth factor +405 cc genotype
    Hans Ivar Hanevik
    Fertilitetsklinikken Sør, Telemark Hospital, Porsgrunn, Norway
    Gynecol Endocrinol 28:845-9. 2012
  7. ncbi HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
  8. pmc Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
    Sukhbir Kaur
    Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:38923-32. 2010
  9. pmc MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1
    Aranzazu Chamorro-Jorganes
    Department of Medicine and Cell Biology, Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA
    Arterioscler Thromb Vasc Biol 31:2595-606. 2011
  10. pmc Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    Jennifer L Spratlin
    FRCPC, Department of Medical Oncology, Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, Canada T5G 1Z2
    J Clin Oncol 28:780-7. 2010

Research Grants

  1. STUART JAMES SHANKLAND; Fiscal Year: 2016
  2. Targeted Modulation of Angiogenesis by VEGFR Peptidomimetic Antagonists
    Renata Pasqualini; Fiscal Year: 2012
  3. Tatiana V Byzova; Fiscal Year: 2016
  4. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
  5. Role of Syntaxin 6 Regulated Post-Golgi Trafficking in Angiogenesis
    Amit Choudhury; Fiscal Year: 2012
  6. A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    APRIL FITZSIMMONS EICHLER; Fiscal Year: 2010
  7. The connection between Notch signaling and VEGFR1 in angiogenesis
    HASINA HAMILTON OUTTZ; Fiscal Year: 2011
  8. Sophia Ran; Fiscal Year: 2014
  9. Therapeutic Angiogenesis for Erectile Dysfunction
    BRIAN ANNEX; Fiscal Year: 2009
  10. Investigation of the VEGFR/Integrin cytoplasmic domains interaction.
    Olga Vinogradova; Fiscal Year: 2011

Detail Information

Publications292 found, 100 shown here

  1. pmc Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways
    Yan Xiong
    Laboratory of Vascular Biology, Institute of Molecular Medicine, Peking University, Beijing 10087, China
    J Biol Chem 284:23217-24. 2009
    ..In this study, we showed that VEGF receptor-2 (VEGFR2), but not VEGFR1, is responsible for VEGF-induced release of von Willebrand factor (vWF), a major marker of WPBs...
  2. doi Vascular endothelial growth factor and its high-affinity receptor (VEGFR-2) are highly expressed in the human forebrain and cerebellum during development
    Loïc Sentilhes
    Neovasc, Rouen Institute for Medical Research and Innovation, Normandy, France
    J Neuropathol Exp Neurol 69:111-28. 2010
    ..We analyzed the distribution of VEGF and its high-affinity receptor VEGFR-2 in the human forebrain and cerebellum at developmental stages from 14 weeks' gestation (WG) to the13th postnatal ..
  3. doi Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4340, USA
    Dev Cell 14:25-36. 2008
    ..This ultimately deprives VEGF receptors of an essential molecule required for promoting the disruption of endothelial cell-cell contacts and paracellular permeability...
  4. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
    ..Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses...
  5. pmc HIV-1 upregulates VEGF in podocytes
    Sonal Navin Korgaonkar
    Department of, New York, Mount Sinai School of Medicine, New York, USA
    J Am Soc Nephrol 19:877-83. 2008
    ..HIV-1 also upregulated VEGFR2 and its co-receptor neuropilin-1 and suppressed the expression of semaphorin 3a in the podocyte...
  6. doi Increased risk of ovarian hyperstimulation syndrome following controlled ovarian hyperstimulation in patients with vascular endothelial growth factor +405 cc genotype
    Hans Ivar Hanevik
    Fertilitetsklinikken Sør, Telemark Hospital, Porsgrunn, Norway
    Gynecol Endocrinol 28:845-9. 2012
    ..Vascular endothelial growth factor (VEGF) and its receptor VEGFR2 have been identified as an important signaling system in mediating this increase...
  7. ncbi HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
    ....
  8. pmc Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
    Sukhbir Kaur
    Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:38923-32. 2010
    ..We now describe a more potent mechanism by which TSP1 inhibits VEGF receptor-2 (VEGFR2) activation through engaging its receptor CD47...
  9. pmc MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1
    Aranzazu Chamorro-Jorganes
    Department of Medicine and Cell Biology, Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA
    Arterioscler Thromb Vasc Biol 31:2595-606. 2011
    ..Vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR2), and fibroblast growth factor receptor-1 (FGFR1) were identified by bioinformatic approaches and subsequently ..
  10. pmc Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    Jennifer L Spratlin
    FRCPC, Department of Medical Oncology, Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, Canada T5G 1Z2
    J Clin Oncol 28:780-7. 2010
    ..a fully human immunoglobulin G(1) monoclonal antibody targeting the vascular endothelial growth factor receptor (VEGFR)-2...
  11. ncbi Increased expression of VEGF-receptors (FLT-1, KDR, NRP-1) and thrombospondin-1 is associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype, in malignant melanoma
    Oddbjørn Straume
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Angiogenesis 6:295-301. 2003
    ..In contrast, GMP expression of bFGF was decreased. Our findings suggest an important role of VEGF-A and its receptors in GMP formation in human cutaneous melanoma...
  12. ncbi A peptide competing with VEGF165 binding on neuropilin-1 mediates targeting of a chlorin-type photosensitizer and potentiates its photodynamic activity in human endothelial cells
    Loraine Tirand
    Centre Alexis Vautrin CRAN, UMR 7039 CNRS UHP INPL, Avenue de Bourgogne, F 54511 Vandoeuvre les Nancy Cedex, France
    J Control Release 111:153-64. 2006
    ..chimeric protein (IC50=19 and 171 microM, respectively) but were devoid of affinity for VEGF receptor type 2 (VEGFR-2, KDR), to which ATWLPPR was initially thought to bind...
  13. doi EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2alpha-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2
    Faten Bougatef
    INSERM Unité 940, Paris, France
    Blood 114:5547-56. 2009
    ..angiogenesis by a direct effect on endothelial cells through a paracrine regulation of the VEGF/VEGF-receptor (VEGFR) system...
  14. pmc VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
    Ingrid Nilsson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    EMBO J 29:1377-88. 2010
    ..They exert their effects by dimerization and activation of the cognate receptors VEGFR2 and VEGFR3. Here, we have used in situ proximity ligation to detect receptor complexes in intact endothelial cells...
  15. ncbi A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Med 9:407-15. 2003
    ..This property seems to be independent of its MMP-inhibitory activity, indicating a new function for this molecule...
  16. ncbi Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum
    Daniel Escorsim Machado
    Department of Histology and Embryology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Fertil Steril 90:148-55. 2008
    ....
  17. ncbi Flk-1+ adipose-derived mesenchymal stem cells differentiate into skeletal muscle satellite cells and ameliorate muscular dystrophy in mdx mice
    Yanning Liu
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Stem Cells Dev 16:695-706. 2007
    ..These cells also differentiated into endothelial cells, thereby possibly improving fiber regeneration as a result of the induced angiogenesis. Therefore, Flk-1(+) AD-MSC transplants may repair muscular dystrophy...
  18. ncbi Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation
    Sylvie Lamy
    Laboratoire de Medecine Moleculaire, Hôpital Ste Justine Université du Québec à Montréal, 3175 Cote Ste Catherine, Montreal, Quebec, Canada, H3T 1C5
    Carcinogenesis 27:989-96. 2006
    ..delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2...
  19. ncbi Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    H P Gerber
    Department of Cardiovascular Research, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 273:30336-43. 1998
    ..Inhibition of apoptosis may represent a major aspect of the regulatory activity of VEGF on the vascular endothelium...
  20. ncbi Shear stress induces expression of vascular endothelial growth factor receptor Flk-1/KDR through the CT-rich Sp1 binding site
    Takeo Abumiya
    National Cardiovascular Center Research Institute, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:907-13. 2002
    ..These results suggest that shear stress induces Flk-1/KDR expression through the CT-rich Sp1 binding site...
  21. ncbi Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells
    Naveed Ahmed Khan
    Division of Pediatric Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurovirol 9:584-93. 2003
    ..IFN-gamma treatment of HBMECs up-regulates vascular endothelial growth factor receptor-2 (VEGFR2/KDR), which is known to be the receptor for Tat...
  22. pmc Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
    Yasunori Shintani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    EMBO J 25:3045-55. 2006
    ..co-receptor for vascular endothelial growth factor (VEGF) that enhances the angiogenic signals cooperatively with VEGFR2. VEGF signaling is essential for physiological and pathological angiogenesis through its effects on vascular ..
  23. ncbi Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma
    Bingzong Li
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P R China
    Stem Cells Dev 16:921-30. 2007
    ..The repressed osteogenesis and TAZ expression were both partially restored by neutralization of TNF-alpha. Thus, the decreased osteogenic potential of MSCs of myeloma patients was in part due to TNF-alpha suppressed TAZ expression...
  24. doi Neuropilin-1 forms complexes with vascular endothelial growth factor receptor-2 during megakaryocytic differentiation of UT-7/TPO cells
    Akimichi Ohsaka
    Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 390:1171-6. 2009
    We investigated whether the gene expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR and neuropilin-1 [NRP-1]) could be specifically regulated during the megakaryocytic differentiation of human thrombopoietin ..
  25. ncbi Pathway analysis in HEK 293T cells overexpressing HIV-1 tat and nucleocapsid
    Min Joo Lee
    Department of Biological Science, Sookmyung Women s University, Seoul 140 742, Korea
    J Microbiol Biotechnol 19:1103-8. 2009
    ..The results indicate that the up- and downregulated genes regulate HIV-1 replication and proliferation, and viral entry...
  26. doi Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy
    Ramazan Demir
    Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
    Folia Histochem Cytobiol 47:435-45. 2009
    ..In the new developing mesenchymal villi and immature intermediate villi VEGF and its receptors VEGFR-1 and VEGFR-2 immunoreactivity was detected in all the placental components, while in the stem villi and in the ..
  27. pmc Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells
    Zeinab Daher
    Department of Biochemistry, Faculty of Medicine, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 285:24591-9. 2010
    ..Taken together, our data indicate that ARF1 is a novel modulator of VEGF-stimulated NO release and signaling in endothelial cells...
  28. doi Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation
    Sophie Pirotte
    Metastasis Research Laboratory, Grappe Disciplinaire de Génoprotéomique Appliquée GIGA Cancer, Liege, Belgium
    Blood 117:2515-26. 2011
    ..junctions and contact inhibition of growth of endothelial cells that is also known to modulate vascular endothelial growth factor receptor 2 (VEGFR-2) activity, the major high-affinity receptor for VEGF...
  29. doi Reduced serum vascular endothelial growth factor receptor-2 (sVEGFR-2) and sVEGFR-1 levels in gastric cancer patients
    Shogo Kikuchi
    Department of Public Health, Aichi Medical University, School of Medicine, Aichi, Japan
    Cancer Sci 102:866-9. 2011
    ..In conclusion, elevated VEGF and reduced sVEGFR-1 and sVEGFR-2 in serum are characteristic of gastric cancer patients, and the value of serum sVEGFR-2 in the diagnosis of diffuse type gastric cancer should be further evaluated...
  30. pmc Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism
    Atul Goyal
    Department of Pathology, Anatomy, and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Biol Chem 286:25947-62. 2011
    ..and porcine endothelial cells, this interaction evokes a physical down-regulation of both the α2β1 integrin and VEGFR2, with concurrent activation of the tyrosine phosphatase SHP-1 and downstream attenuation of VEGFA transcription...
  31. doi PDGF-induced migration of vascular smooth muscle cells is inhibited by heme oxygenase-1 via VEGFR2 upregulation and subsequent assembly of inactive VEGFR2/PDGFRβ heterodimers
    Caroline Cheng
    Molecular Cardiology Laboratory, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 32:1289-98. 2012
    ..However, the effect of HO-1 on VSMC migration remains unclear. We aim to elucidate the mechanism by which HO-1 regulates PDGFBB-induced VSMC migration...
  32. doi Role and regulation of VEGF and its receptors 1 and 2 in the aseptic loosening of total hip implants
    Ville Waris
    Mikkeli Central Hospital, 50100 Mikkeli, Finland
    J Orthop Res 30:1830-6. 2012
    ..001) and stromal macrophage-like cells (p < 0.05) were more numerous in rTHR than in OA. As to VEGFR2(+), only stromal fibroblast-like cells in rTHR outnumbered those found in OA (p < 0.05)...
  33. pmc Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells
    Rafi Mazor
    Department of Bioengineering, The Institute of Engineering in Medicine, Veterans Affairs Medical Center, San Diego, California, USA
    J Biol Chem 288:598-607. 2013
    ..Vascular endothelial growth factor receptor-2 (VEGFR2), the main receptor for VEGF-A, is expressed on endothelial cells and promotes cell survival, proliferation, and ..
  34. doi MiR-17-3p inhibits angiogenesis by downregulating flk-1 in the cell growth signal pathway
    Runting Yin
    Department of Pharmacology, Nantong University Medical College, Nantong, PR China
    J Vasc Res 50:157-66. 2013
    ....
  35. ncbi Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling
    Konstantin V Stoletov
    Cardiology Division, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    FASEB J 16:1283-5. 2002
    ..The ability of FRS2 to recruit cell-signaling proteins to the cell is significant because it provides a mechanism for enhancing the repertoire of VEGF-induced signaling pathways...
  36. ncbi Snake venom vascular endothelial growth factors (VEGFs) exhibit potent activity through their specific recognition of KDR (VEGF receptor 2)
    Yasuo Yamazaki
    Department of Biochemistry, Meiji Pharmaceutical University, 2 522 1, Noshio, Kiyose, Tokyo 204 8588, Japan
    J Biol Chem 278:51985-8. 2003
    ..Our data clearly indicate that snake venom VEGFs act through the specific activation of KDR and show potent effects. Snake venom VEGFs are a highly specific ligand to KDR and form a new group of the VEGF family...
  37. ncbi An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody
    Juqun Shen
    ImClone Systems Incorporated, New York, NY 10014, USA
    Biochem Biophys Res Commun 357:1142-7. 2007
    ..the antitumor and the anti-angiogenic activities of DC101, an antibody directed against mouse vascular endothelial growth factor receptor 2, in a pancreatic (BxPC-3) and a non-small cell lung (NCI-H460) tumor xenograft models...
  38. doi The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells
    Alfonso Catalano
    Department of Molecular Pathology and Innovative Therapies, Marche University, Ancona, Italy
    Cancer Res 69:1485-93. 2009
    ..This work identifies a new biological function of semaphorins in cancer cells and suggests the involvement of an undescribed survival pathway during MPM tumorigenesis...
  39. doi Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: a new mechanism for the emphysema-like changes observed in Fut8-deficient mice
    Xiangchun Wang
    Department of Disease Glycomics, Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Biochem 145:643-51. 2009
    ..The results of the present study demonstrated that vascular endothelial growth factor receptor-2 (VEGFR-2) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 ..
  40. doi Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Atherosclerosis 208:512-7. 2010
    ..growth factor (VEGF) plays a key role in angiogenesis through binding to its specific receptor, VEGF receptor-2 (VEGFR-2), whereas the expression of VEGF and VEGFR-2 in the myocardium of insulin-resistant rats is down-regulated...
  41. pmc Maternal circulating CD34+VEGFR-2+ and CD133+VEGFR-2+ progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia
    Patrizia Luppi
    Department of Pediatrics, Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Reprod Sci 17:643-52. 2010
    ..Cells expressing CD34 or CD133, in combination with vascular endothelial growth factor receptor-2 (VEGFR-2), were enumerated by flow cytometry...
  42. doi MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src
    Patricia A Eisenach
    University of Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    J Cell Sci 123:4182-93. 2010
    ..We discovered that MT1-MMP regulates VEGFR-2 cell surface localisation and forms a complex with VEGFR-2 and Src that is dependent on the MT1-MMP hemopexin ..
  43. ncbi Age-related changes in apoptosis and expressions of intercellular adhesion molecule-1 and vascular endothelial growth factor receptor type 2 in the wall of varicose veins
    H E Simovart
    Department of Anatomy, University of Tartu, 19 Ravila Street, Tartu, Estonia helle evi simovart ut ee
    Int Angiol 29:507-13. 2010
    ....
  44. ncbi High articular levels of the angiogenetic factors VEGF and VEGF-receptor 2 as tissue healing biomarkers after single bundle anterior cruciate ligament reconstruction
    E Galliera
    Dipartimento di Morfologia Umana e Scienze Biomediche, Universita degli Studi di Milano, Milan, Italy
    J Biol Regul Homeost Agents 25:85-91. 2011
    ..Analysis of vascular endothelial growth factor (VEGF) and its receptors, VEGFR1 and VEGFR2, may be useful in the clinical assessment of bone and soft-tissue remodeling...
  45. pmc Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblast
    Gausal A Khan
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Mol Endocrinol 25:1431-43. 2011
    ..growth factor-receptor (EGF-R), IGF receptor-1 (IGFR1), and vascular endothelial growth factor 2 receptor (VEGFR-2)]...
  46. ncbi Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis
    B A Keyt
    Department of Cardiovascular Research, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 271:5638-46. 1996
    ..vascular permeability via the endothelial cell receptors, kinase insert domain-containing receptor (KDR)/fetal liver kinase 1 (Flk-1) and FLT-1...
  47. pmc Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes
    Alessia A Bettaccini
    Dipartimento di Scienze Cliniche e Biologiche, Universita dell Insubria, Varese, Italy
    BMC Microbiol 5:20. 2005
    ..The activity of two-exon (aa 1-101) and synthetic (aa 1-86) Tat was studied on mammary and amniotic epithelial cells cultured under low serum conditions...
  48. ncbi Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins
    Kelly J Higgins
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, USA
    Biochem Biophys Res Commun 345:292-301. 2006
    Vascular endothelial growth factor receptor-2 (VEGFR2/KDR) is an important mediator of angiogenesis, and VEGFR2 mRNA is expressed in several pancreatic cancer cell lines...
  49. pmc Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
    M G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 95:548-53. 1998
    ..Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However. VEGF-D does not bind to VEGFR-1...
  50. pmc A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
    W Matthews
    Department of Molecular Biology, Princeton University, NJ 08544
    Proc Natl Acad Sci U S A 88:9026-30. 1991
    We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells...
  51. ncbi HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment
    M Arese
    Institute for Cancer Research and Treatment and Department of Genetics, Biology and Biochemistry, School of Medicine, University of Torino, Candiolo Italy
    J Immunol 166:1380-8. 2001
    ..These results highlighted the role of PAF and MCP-1 as secondary mediators in the onset of lymphomononuclear cell recruitment in tissues triggered by Tat...
  52. pmc PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation
    Rosana D Meyer
    Department of Pathology, Boston University Medical Campus, 670 Albany St, Boston, MA 02118, USA
    Mol Cell Biol 31:2010-25. 2011
    The internalization and degradation of vascular endothelial growth factor receptor 2 (VEGFR-2), a potent angiogenic receptor tyrosine kinase, is a central mechanism for the regulation of the coordinated action of VEGF in angiogenesis...
  53. pmc Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells
    R K Ganju
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Virol 72:6131-7. 1998
    ..These studies reveal that Tat stimulation activates a number of signal transduction pathways that are associated with cell growth and migration...
  54. ncbi Kaposi's sarcoma cells of different etiologic origins respond to HIV-Tat through the Flk-1/KDR (VEGFR-2): relevance in AIDS-KS pathology
    M Morini
    Molecular Biology Laboratory, Tumor Progression Section, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, Genoa, 16132, Italy
    Biochem Biophys Res Commun 273:267-71. 2000
    ....
  55. ncbi Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro
    P Koolwijk
    Gaubius Laboratory TNO PG, Zernikedreef 9, 2333 CK Leiden, The Netherlands
    Angiogenesis 4:53-60. 2001
    Different forms of vascular endothelial growth factor (VEGF) and their cellular receptors (VEGFR) are associated with angiogenesis, as demonstrated by the lethality of VEGF-A, VEGFR-1 or VEGFR-2 knockout mice...
  56. ncbi Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)
    Laura K Schaefer
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:2058-65. 2002
    ..protein have shown that coexpression of Stat3alpha and the vascular endothelial growth factor receptor-2 (VEGFR-2) result in ligand-independent activation of Stat3alpha tyrosine phosphorylation and subsequent transcriptional ..
  57. ncbi Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway
    Rong Zhang
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:51267-76. 2003
    ..TNF induces a coordinated phosphorylation of vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) and Etk, which is blocked by VEGFR2-specific inhibitors...
  58. ncbi Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition
    John A Marwick
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 290:L897-908. 2006
    ..VEGF(165) signaling through VEGF receptor (VEGFR)-2/kinase insert domain receptor (KDR) is a highly regulated process involving the formation of a tertiary complex ..
  59. ncbi Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins
    Kelly J Higgins
    Department of Biochemistry, Texas A and M University, College Station, 77843 4466, USA
    Endocrinology 147:3285-95. 2006
    Vascular endothelial growth factor receptor-2 kinase insert domain receptor (VEGFR2/KDR) is critical for angiogenesis, and VEGFR2 mRNA and protein are expressed in ZR-75 breast cancer cells and induced by 17beta-estradiol (E2)...
  60. ncbi The effects of VEGF and VEGFR-2 on survival in patients with gastric cancer
    F Ozdemir
    Department of Medical Oncology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey
    J Exp Clin Cancer Res 25:83-8. 2006
    ..Thus, we investigated the effects of VEGF and VEGF receptor-2 (VEGFR-2, KDR) on survival in patients with gastric cancer...
  61. ncbi Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
    Laurent Lamalice
    Centre de recherche en cancérologie de l Université Laval, 9 rue McMahon, Quebec G1R 2J6, Canada
    J Biol Chem 281:34009-20. 2006
    b>VEGFR-2 is the major receptor that regulates the different functions of VEGF in adults...
  62. ncbi Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2
    Bradley K McColl
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    FASEB J 21:1088-98. 2007
    ..It consists of a central domain, containing binding sites for VEGF receptor-2 (VEGFR-2) and VEGFR-3, and N- and C-terminal propeptides...
  63. pmc Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit, University of Sheffield, E Floor, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    BMC Med Genet 8:23. 2007
    Vascular endothelial growth factor (VEGF) has neurotrophic activity which is mediated by its main agonist receptor, VEGFR2. Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), ..
  64. doi Human CD4+ T lymphocytes recognize a vascular endothelial growth factor receptor-2-derived epitope in association with HLA-DR
    Yuansheng Sun
    Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany
    Clin Cancer Res 14:4306-15. 2008
    ..Recently, the first human tumor endothelial antigen vascular endothelial growth factor receptor-2 (VEGFR-2) recognized by HLA class I-restricted CD8(+) T cells has been characterized...
  65. ncbi Identification of a new endothelial cell growth factor receptor tyrosine kinase
    B I Terman
    Medical Research Division, Lederle Laboratories, Pearl River, New York 10965
    Oncogene 6:1677-83. 1991
    ..e. an ATP-binding site, a membrane-spanning region, split tyrosine kinase regions) typical of a type III receptor tyrosine kinase. The KDR gene is expressed as a 7.0 kb transcript, and is localized to human chromosome 4...
  66. ncbi Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
    J Waltenberger
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    J Biol Chem 269:26988-95. 1994
    ..e. in the presence of Flt1. This difference could possibly be explained by the formation of heterodimeric complexes between KDR and Flt1, or other molecules, in HUVE cells...
  67. ncbi Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
    M Dougher
    Wyeth Ayerst Oncology Research, Pearl River, New York 10965, USA
    Oncogene 18:1619-27. 1999
    ..Maximal rates of receptor kinase activity is required for VEGF-induced receptor internalization, as internalization was delayed in the KDR(Y1054,1059F) expressing cells when compared to cells expressing native receptor...
  68. ncbi Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
    Haiyan Jia
    Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    J Biol Chem 279:36148-57. 2004
    Vascular endothelial growth factor (VEGF)-D binds to VEGF receptors (VEGFR) VEGFR2/KDR and VEGFR3/Flt4, but the signaling mechanisms mediating its biological activities in endothelial cells are poorly understood...
  69. ncbi Expression of vascular endothelial growth factor (VEGF) and its receptors in thyroid carcinomas of follicular origin: a potential autocrine loop
    Joaquim Miguel Vieira
    Centro de Investigacao de Patobiologia Molecular CIPM, S A, Rua Professor Lima Basto, 1099 023 Lisboa, Portugal
    Eur J Endocrinol 153:701-9. 2005
    The aim of this study was to clarify the role of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) pathways in thyroid tumourigenesis.
  70. pmc Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
    Maria Grazia Lampugnani
    IFOM, Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, University of Milan, 20139 Milan, Italy
    J Cell Biol 174:593-604. 2006
    ..In a previous study, we found that the association of vascular endothelial cadherin (VEC) with VEGF receptor (VEGFR) type 2 contributes to density-dependent growth inhibition (Lampugnani, G.M., A. Zanetti, M. Corada, T...
  71. ncbi Structure of a VEGF-VEGF receptor complex determined by electron microscopy
    Claudia Ruch
    Paul Scherrer Institut, Biomolecular Research, Molecular Cell Biology, CH 5232 Villigen PSI, Switzerland
    Nat Struct Mol Biol 14:249-50. 2007
    ..Here we show that the monomeric extracellular domain of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) has a flexible structure...
  72. ncbi Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting
    Qi Pan
    Department of Tumor Biology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 282:24049-56. 2007
    ..b>VEGFR2 complex. Additionally, we show that VEGFR2 enhances VEGF(165), but not VEGF(121) binding to NRP1...
  73. ncbi Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia
    Jewon Ryu
    Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong Songpa gu 138 736, Seoul 138 736, Republic of Korea
    Cardiovasc Res 78:333-40. 2008
    ..The present study investigated the detailed mechanism by which fractalkine (Fkn), a CX3C chemokine, induces angiogenesis and its functional implication in alleviating ischaemia in vivo...
  74. pmc Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology and Mayo Clinic Cancer Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Mol Signal 3:8. 2008
    Vascular endothelial growth factor receptor-2 (VEGFR-2, KDR), a receptor tyrosine kinase, regulates mitogenic, chemotactic, hyperpermeability, and survival signals in vascular endothelial cells in response to its ligand vascular ..
  75. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
    ..Previous work has shown that beta3 integrin can regulate negatively VEGFR2 expression...
  76. doi Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis
    Alexander F Bruns
    Endothelial Cell Biology Unit, Institute of Molecular and Cellular Biology, LIGHT Laboratories, University of Leeds, Leeds LS2 9JT, UK
    Traffic 11:161-74. 2010
    ..A soluble VEGFR2 cytoplasmic domain fragment displayed tyrosine phosphorylation and activation of downstream intracellular ..
  77. pmc Mechanical signals activate vascular endothelial growth factor receptor-2 to upregulate endothelial cell proliferation during inflammation
    Jie Liu
    Biomechanics and Tissue Engineering Laboratory, Division of Oral Biology, The Ohio State University College of Dentistry, Columbus, OH 43210, USA
    J Immunol 185:1215-21. 2010
    ..article, we demonstrate that the mechanosignaling cascade is initiated by vascular endothelial growth receptor-2 (VEGFR2) activation...
  78. doi Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer
    J Pander
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Oncol 22:1147-53. 2011
    ..Genetic interaction analysis is used as a rational tool to study the contribution of polygenic variation in relation to drug response...
  79. doi Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization
    Denis Tvorogov
    Institute for Molecular Medicine Finland, Department of Pathology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, Finland
    Cancer Cell 18:630-40. 2010
    ..Typically receptor-blocking antibodies are targeted to the VEGFR ligand-binding site...
  80. doi The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling
    Helen M Jopling
    Endothelial Cell Biology Unit, Institute of Molecular and Cellular Biology, University of Leeds, LIGHT Laboratories, Clarendon Way, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 410:170-6. 2011
    The VEGFR2 receptor tyrosine kinase regulates vascular physiology and animal development. The mechanism underlying VEGFR2 membrane trafficking is not well understood...
  81. doi Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output
    Kurt Ballmer-Hofer
    Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institute, Villigen, Switzerland
    Blood 118:816-26. 2011
    ..factors (VEGFs) regulate blood and lymph vessel development by activating 3 receptor tyrosine kinases (RTKs), VEGFR-1, -2, and -3, and by binding to coreceptors such as neuropilin-1 (NRP-1)...
  82. doi c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1
    Francesca Anselmi
    Dipartimento di Biotecnologie, Universita di Siena, Siena, Italy
    Angiogenesis 15:187-97. 2012
    ..These findings suggest that c-ABL function is to establish a correct and tightly controlled response of endothelial cells to VEGF-A during the angiogenic process...
  83. pmc Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
    Petra Hamerlik
    Danish Cancer Society Research Center and Centre for Genotoxic Stress Research, DK 2100 Copenhagen, Denmark
    J Exp Med 209:507-20. 2012
    Although vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) is traditionally regarded as an endothelial cell protein, evidence suggests that VEGFRs may be expressed by cancer cells...
  84. pmc Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation
    Ralph Francescone
    Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 287:24821-31. 2012
    ..Collectively, all the data demonstrate a central role of Flk-1 in the formation of VM in GBM. This study has shed light on molecular mechanisms mediating tumor aggressiveness and also provided a therapeutic target for patient treatment...
  85. ncbi The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
    J Kroll
    Department of Internal Medicine II Cardiology, Ulm University Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Federal Republic of Germany
    J Biol Chem 272:32521-7. 1997
    ..Taken together, our results substantially broaden the spectrum of KDR-associating molecules, indicating that endothelial function and angiogenesis are regulated by a diverse network of signal transduction cascades...
  86. ncbi Molecular mediators of tumor angiogenesis: enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer
    A Kranz
    Department of Internal Medicine II, Ulm University Medical Center, Germany
    Int J Cancer 84:293-8. 1999
    ..Our data demonstrate that KDR activation is enhanced in breast cancer in vivo and emphasize the functional role of VEGF and KDR in the development of malignant breast disease...
  87. ncbi HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity
    L Huang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:38183-8. 1999
    ..In order to define signaling pathways downstream of VEGF receptors (VEGFR), the kinase domain of VEGFR2 (Flk-1) was used as a bait to screen a human fetal heart library in the yeast two-hybrid system...
  88. ncbi Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling
    Kirsty E Ratcliffe
    Department of Medicine, Cardiology Division, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Oncogene 21:6307-16. 2002
    ..Taken together, these results demonstrate that Sck is expressed in vascular endothelial cells, and participates in VEGF-induced signal transduction...
  89. ncbi Fluid shear stress-induced transcriptional activation of the vascular endothelial growth factor receptor-2 gene requires Sp1-dependent DNA binding
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    FEBS Lett 535:87-93. 2003
    ..Together, these results suggest that biomechanical stimulation may lead to endothelial cell survival by upregulating VEGF receptor-2 expression...
  90. ncbi Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells
    Martine Duval
    Laboratory of Endothelial Cell Biology, Institut de recherches cliniques de Montreal IRCM, Quebec H2W 1R7, Canada
    J Biol Chem 278:20091-7. 2003
    ..Cbl thus plays a role in the regulation of VEGF signaling by mediating the stimulated ubiquitination and, consequently, degradation of Flk-1 in endothelial cells...
  91. pmc Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF
    Bénédicte Masson-Gadais
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, 9 rue McMahon, Quebec, G1R 2J6, Canada
    Cell Stress Chaperones 8:37-52. 2003
    ..vein endothelial cells cultivated on vitronectin triggers a synergistic interaction between the VEGF receptor VEGFR2 and the clustered integrin receptor alphavbeta3...
  92. ncbi Angiogenic growth factor response to acute systemic exercise in human skeletal muscle
    Timothy P Gavin
    Department of Exercise and Sport Science, East Carolina Univiversity, Greenville, NC 27858, USA
    J Appl Physiol (1985) 96:19-24. 2004
    ..Acta Physiol Scand 175: 201-209, 2002); and 3) VEGF protein is decreased immediately after exercise...
  93. ncbi The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
    Kristina Holmqvist
    Department of Medical Cell Biology, Uppsala University, Uppsala 75123, Sweden
    J Biol Chem 279:22267-75. 2004
    ..growth factor (VEGF) stimulation using porcine aortic endothelial cells expressing the human VEGF receptor 2 (VEGFR-2) (KDR)...
  94. ncbi Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer
    Paul Eduard Neagoe
    Research Center, Montreal Heart Institute, Department of Pharmacology, Universite de Montreal, 5000 Belanger St, Montreal, Quebec H1T 1C8, Canada
    J Biol Chem 280:9904-12. 2005
    ..by acute platelet-activating factor synthesis from endothelial cells upon the activation of VEGF receptor-2 (VEGFR-2) and its coreceptor, neuropilin-1 (NRP-1)...
  95. ncbi Association between genetic variations of vascular endothelial growth factor receptor 2 and atopy in the Korean population
    Heung Woo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Yongun dong, Chongno Gu, Korea
    J Allergy Clin Immunol 117:774-9. 2006
    ..Vascular endothelial growth factor (VEGF) has been suggested to be a key mediator in the development of atopy and T(H)2 inflammation...
  96. ncbi Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis
    Taro Matsumoto
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 13:130-5. 2006
    ..a critical role in vascular development and angiogenesis through its binding and activation of VEGF receptor-2 (VEGFR-2)...
  97. doi Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2
    David I R Holmes
    Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, United Kingdom
    Cell Signal 20:569-79. 2008
    ..VEGF-A(165), acting via VEGFR2/KDR, induced STC-1 through de novo transcription, mediated primarily via intracellular protein kinase C (PKC)- and ..
  98. doi Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors
    Jung Hyun Park
    Laboratory for Cancer Epigenetics and Experimental Therapeutics, Cancer Research Institute, Seoul, Republic of Korea
    Biochem Biophys Res Commun 368:318-22. 2008
    ..In this study, we report that histone deacetylase inhibitors (HDIs) induce a reduction in VEGFR1 and VEGFR2 protein expression via the inhibition of class II histone deacetylases (HDACs) in human cancer cell lines...
  99. ncbi Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay
    Petra Knizetova
    Faculty of Medicine, Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    Cell Cycle 7:2553-61. 2008
    ..Morevover, we demonstrated that the autocrine VEGF signaling is mediated via VEGFR2 (KDR), and involves co-activation of the c-Raf/MAPK, PI3K/Akt and PLC/PKC pathways...
  100. doi Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells
    Barbara Olszewska-Pazdrak
    Dept of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    Am J Physiol Cell Physiol 296:C1162-70. 2009
    ..These data provide a novel explanation for the impaired angiogenic responses to VEGF in endothelial cells exposed to chronic hypoxia...
  101. pmc Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma
    Adhemar Longatto-Filho
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    BMC Cancer 9:212. 2009
    ..The objective of this study was to investigate EGFR, PDGFRA and VEGFR2 RTKs overexpression and activating gene mutations in a cohort of 30 adenosquamous carcinomas of the uterine cervix.

Research Grants72

  1. STUART JAMES SHANKLAND; Fiscal Year: 2016
    ..New studies have identified pericyte to endothelial signaling via Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) as a central pathway in regulating pericyte detachment and kidney disease progression...
  2. Targeted Modulation of Angiogenesis by VEGFR Peptidomimetic Antagonists
    Renata Pasqualini; Fiscal Year: 2012
    ..Our goal is to understand and inhibit pathological angiogenesis in the neural retina of experimental mouse models of human blindness-causing diseases. ..
  3. Tatiana V Byzova; Fiscal Year: 2016
    ..As our specific hypotheses, we propose that VEGFR2/[unreadable]V[unreadable]3 complex is crucial for the regulation of integrin-dependent functions and for the ..
  4. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..Single injections in mice of these adenoviruses produce high levels of circulating soluble Flk1 and Flt1 ectodomains which persist for >3-4 weeks, potently suppressing tumor growth and angiogenesis, and ..
  5. Role of Syntaxin 6 Regulated Post-Golgi Trafficking in Angiogenesis
    Amit Choudhury; Fiscal Year: 2012
    ..in signaling proteins including certain kinases, integrins and vascular endothelial growth factor receptor-2 (VEGFR2), all of which are believed to play roles in angiogenesis...
  6. A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    APRIL FITZSIMMONS EICHLER; Fiscal Year: 2010
    ..Angiogenesis in solid tumors is driven by VEGF via the endothelial growth factor receptor, VEGFR2. VEGFR2 is the major mediator of several physiological and pathological effects of VEGF-A on endothelial cells, ..
  7. The connection between Notch signaling and VEGFR1 in angiogenesis
    HASINA HAMILTON OUTTZ; Fiscal Year: 2011
    ..the Notch signaling pathway in angiogenesis and the role that Notch target genes, specifically VEGF receptor-1 (VEGFR-1), play in the survival, sprouting, and proliferation of endothelial cells in response to angiogenic stimuli...
  8. Sophia Ran; Fiscal Year: 2014
    ..that activation of the NF-?B pathway increases expression of vascular endothelial growth factor receptor-3 (VEGFR-3), the main receptor driving lymphangiogenesis and lymphatic metastasis...
  9. Therapeutic Angiogenesis for Erectile Dysfunction
    BRIAN ANNEX; Fiscal Year: 2009
    ..III: When a major end-product of the VEGFR/PI3-kinase-Akt pathway is absent, determine the potential mechanisms of, as well the vulnerability to, ..
  10. Investigation of the VEGFR/Integrin cytoplasmic domains interaction.
    Olga Vinogradova; Fiscal Year: 2011
    ..one of the key physiological mechanisms of aV[unreadable]3 activation on endothelium is via VEGF/VEGF receptor 2 (VEGFR2)...
  11. Kishore K Wary; Fiscal Year: 2016
    ..process that requires not only the action of vascular endothelial growth factor (VEGF) and the VEGF receptor-2 (VEGFR2) system, but also activation of the wingless (Wnt) pathway...
  12. Keratinocyte responses to vascular endothelial growth factor in carcinogenesis
    Traci A Wilgus; Fiscal Year: 2012
    ..evidence that the effects of VEGF may not be restricted to endothelial cells is emerging, as VEGF receptors (VEGFR-1 and VEGFR-2) can be expressed by a subset of non-endothelial cell types...
  13. Magdalena Chrzanowska; Fiscal Year: 2016
    ..proliferation and increased vascular permeability are mediated in part via cell surface receptor VEGF Receptor 2 (VEGFR2). Small GTPase Rac1 is involved in each of the VEGF-mediated readouts in ECs...
  14. The Role of Vascular Flt-1 in Endothelial-Pericyte Interactions
    JOHN CHRISTOPHER CHAPPELL; Fiscal Year: 2013
    ..VEGF receptor Flt-1 (VEGFR-1) contributes to network formation via heterogeneous expression of the soluble isoform (sFlt-1) that in turn ..
  15. VEGF and PDGF in angiogenesis and tumor progression
    David A Cheresh; Fiscal Year: 2013
    ..A major goal of our proposed studies will be to characterize the composition of the PDGFR2/VEGFR2 complex on tumor vessel associated pericytes and investigate how it regulates the cell migration and proliferation ..
  16. Michael Simons; Fiscal Year: 2016
    ..to explore another novel aspect of VEGF signaling discovered by our lab- spatial control of VEGF receptor 2 (VEGFR2) signaling...
  17. Targeted photoacoustic imaging of VEGF receptors in angiogenic vasculature
    Joseph M Backer; Fiscal Year: 2011
    ..a contrast agent for photoacoustic imaging targeted to the receptors of vascular endothelial growth factor (VEGFR), so it can be accumulated and retained in tumor endothelial cells by VEGFR-mediated endocytosis...
  18. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..AX-3) that inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor 2 (VEGFR2), and insulin receptor (IR)...
  19. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..by the RPTPs of three growth factor receptor TK orthologs: epidermal growth factor receptor (Egfr), Btl, and Pvr (VEGFR ortholog)...
  20. Molecular mechanisms of choroidal neovascularization and vascular homeostasis
    ALEXANDER GEORG MARNEROS; Fiscal Year: 2011
    ..directed towards a comprehensive analysis of the individual contributions of VEGF and the VEGF-receptors Flt1 and Flk1 for choroidal vascular functions, and towards exploring these signaling pathways as molecular targets for novel ..
  21. Nitric Oxide in Tumor Angiogenesis, Microcirculation and Radiation Therapy
    Dai Fukumura; Fiscal Year: 2012
    ..Recent results show that blockade of vascular endothelial growth factor receptor 2 (VEGFR2) transiently improves perivascular cell coverage, tissue oxygenation and response to ..
  22. Functional characterization of a novel adult renal progenitor cell population
    TROY D CAMARATA; Fiscal Year: 2011
    ..a novel intrarenal cell population, defined by co-expression of vascular-endothelial growth factor receptor-2 (Flk1) and stem cell antigen-1 (Sca1), in adult mouse kidney cortex...
  23. JENNIFER MARIE CHOW; Fiscal Year: 2016
    ..3) The mechanisms and impact of crosstalk between RET and vascular endothelial growth factor receptor 2 (VEGFR2) will be explored, to establish at what levels in RET signaling crosstalk occurs and ..
  24. DANIEL J CARR; Fiscal Year: 2016
    ..VEGF) A response by corneal epithelium infected with HSV-1 elicits lymphangiogenesis thru a VEGF receptor 2 (VEGFR2)-mediated pathway. This process is independent of VEGF C, VEGF receptor 3, or monocytes/macrophages...
  25. Fabio A Recchia; Fiscal Year: 2015
    ..Similar to PlGF, it binds selectively the receptor VEGFR-1...
  26. Non-canonical VEGF receptor signaling regulates retinal neovascularization
    MICHAEL EDWIN BOULTON; Fiscal Year: 2012
    ..is now apparent from our work and others that the signaling mediated by ligands binding to the VEGFRs (VEGFR1 and VEGFR2) is much more complex and involves intracellular trafficking of VEGFRs...
  27. Ali Syed Arbab; Fiscal Year: 2016
    ..We hypothesize that anti-angiogenic treatment using VEGFR inhibitors (such as vetanalib) will cause hypoxia due to vascular loss and decreased endothelial cell (EC) ..
  28. Quantitative Biomarker Imaging for Early Therapy Response Assessment in Cancer
    James M Mountz; Fiscal Year: 2013
    ..factor receptor (EGFR) and angiogenesis, including vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR)...
  29. Takamune Takahashi; Fiscal Year: 2016
    ..VEGF/VEGFR was shown to serve as a driving force of this...
  30. Debabrata Mukhopadhyay; Fiscal Year: 2014
    ..survival, and differentiation (arterial-venous cell fate specification) through its two tyrosine kinase receptors, VEGFR-1 and VEGFR-2 and non-tyrosine kinase receptors neuropilins (NRPs)...
  31. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..Specifically, oxygen fluctuations upregulate Mueller cell VEGF and increase VEGF-VEGFR2 signaling in dividing endothelial cells (ECs) at the migrating front to disorient mitotic EC cleavage planes and ..
  32. Molecular insights into the pathogenesis of Sorsby Fundus Dystrophy
    Jian Hua Qi; Fiscal Year: 2013
    ..SFD models indicate that SFD-related S156C- TIMP3 promotes CNV via vascular endothelial growth factor receptor-2 (VEGFR-2)- and retinal pigment epithelial (RPE) cell-dependent angiogenic pathways...
  33. MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2016
    ..Specifically, oxygen fluctuations and relative tissue hypoxia upregulate Mueller cell VEGF and increases VEGF-VEGFR2 signaling in dividing endothelial cells (ECs) at the migrating front to disorient mitotic EC cleavage planes and ..
  34. VEGFR-2 Targeted Imaging
    Zhen Cheng; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Vascular endothelial growth factor (VEGF) receptors VEGFR-1 (FLT-1) and VEGFR-2 (KDR/Flk-1) are prime targets for anti-angiogenic therapeutics because they are up-regulated on tumor vascular ..
  35. COMBINED ULTRASOUND/MOLECULAR ANALYSIS OF TUMOR RESPONSE TO VEGF BLOCKADE
    Jessica J Kandel; Fiscal Year: 2010
    ..members of gene families that are essential to angiogenesis, including integrins (alphaVbeta3), VEGF receptors (VEGFR-1 and -2), and Notch family members (Jagged-1), and mediators of the response to hypoxia (such as COX-2)...
  36. David M Briscoe; Fiscal Year: 2016
    ..The novelty of this research proposal relates to recent observations that the VEGF receptors (VEGFR) KDR (VEGFR2), Flt-1 (VEGFR1) and neuropilin family molecules are expressed on populations of effector, memory and FOXP3high T ..
  37. New Strategies for Photoimmunodetection/therapy
    MARK DAVID SAVELLANO; Fiscal Year: 2010
    ..These receptors are ideal targets for PID/PIT since they are often overexpressed and/or overactivated in many cancers, especially aggressive high-risk breast cancers. ..
  38. KDR--A NOVEL FUNCTIONAL HEMATOPOIETIC STEM CELL MARKER
    Cesare Peschle; Fiscal Year: 2004
    ..b>Vascular endothelial growth factor receptor 2 (VEGFR2, Flk1 in mouse and KDR in men) is a key functional marker in embyronic ..
  39. Rupal S Bhatt; Fiscal Year: 2014
    ..In addition, we have found evidence that resistance to VEGFR TKI therapy is reversible as resistant tumors respond to therapy again when they are reimplanted into naive hosts...
  40. VEGF blockade and alternative angiogenic pathways in neuroblastoma
    Darrell J Yamashiro; Fiscal Year: 2012
    ..VEGF can bind to both VEGF-receptor-1 (VEGFR1) and VEGFR2, but much prior work indicates that VEGF stimulates angiogenesis primarily via VEGFR2...
  41. Extracellular Matrix as a Solid-State Regulator During Angiogenesis
    Donald E Ingber; Fiscal Year: 2011
    ..factor TFII-I and thereby controls expression of the vascular endothelial growth factor (VEGF) receptor VEGFR2. Thus, the specific aims include: 1) To explore how stress- dependent activation of (31 integrin and Rho alter ..
  42. Endothelial Cell in Progressive Renal Disease
    Richard Johnson; Fiscal Year: 2009
    ..that the specific VEGF receptors may govern whether VEGF stimulation is good or bad, in that stimulation of VEGFR-1 is expected to exacerbate renal vascular injury whereas stimulation of VEGFR-2 should accelerate capillary ..
  43. Signaling mechanisms underlying VEGF-induced neuroprotection in vivo
    Susan Croll; Fiscal Year: 2007
    ..Inhibiting VEGF receptor 2 (VEGFR2) activity with Sugen 1498 also blocks neuroprotection in these cells (unpublished data)...
  44. Diabetic Albuminuria and VEGF and Nephrin
    Sheldon Chen; Fiscal Year: 2007
    ..We hypothesize that the VEGFR-1 receptor in the podocyte was predominantly responsible for the manifestations of diabetic nephropathy that were ..
  45. Interaction of Angiopoietin & VEGF signals in arthritis
    P Charles Lin; Fiscal Year: 2010
    ..Tie2 and VEGF receptor (VEGFR) are two endothelium- specific receptor tyrosine kinases...
  46. Vascular Differentiation and Patterning
    Takashi Mikawa; Fiscal Year: 2012
    ..mesoderm;b) BMP antagonist-treatment of differentiated endothelial cells results in a rapid loss of VEGF receptor Vegfr2 protein (also known as Flk1), while Vegfr2 mRNA levels remain unaffected;and c) the expression of BMP antagonists ..
  47. Martin A Schwartz; Fiscal Year: 2016
    ..PECAM-1 appears to be the true force transducer, VE-cadherin functions as an adapter that brings VEGFR2 into the complex and the VEGFR tyrosine kinase initiates key downstream signals...
  48. Role of RPE-derived VEGF in Choroid Development and Stability
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
    ..2) To determine if VEGF has autocrine effects on RPE in vivo and in vitro. RPE cells express VEGFR2 in adult, but not during development...
  49. LOUIS CHARLES GERSTENFELD; Fiscal Year: 2015
    ..morphogenesis and the induction of BMP2 in endothelial cells by altering vascular morphogenesis through blocking VEGFR 1 and 2 activities...
  50. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..ECs secrete VEGF and VEGF in turn activates VEGFR2 receptors on ECs in an autocrine and paracrine manner...
  51. GCL-M Regulation of Angiogenesis
    CHRISTOPHER BRUCE PATTILLO; Fiscal Year: 2010
    ..VEGF after association with its receptor (VEGFR2) acts through a reactive oxygen species (ROS) dependent mechanism allowing it to initiate a signaling process ..
  52. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..Immunocytochemistry for vascular endothelial growth factor (VEGF), its receptor VEGFR-2, brain derived neurotrophic factor (BDNF), its receptor TrkB will be used to identify their expression in HF ..
  53. Changwon Park; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): FLK1 (VEGFR2), a receptor tyrosine kinase, is a critical component for blood cell and vessel formation as evidenced by knockout studies...
  54. Profilin-1 phosphorylation in neovascularization
    Yi Fan; Fiscal Year: 2013
    ..Interestingly, Pfn-1 phosphorylation is directly induced by VEGFR2/Src, independent of classic PI3K-mediated multistep signal cascades...
  55. Noorjahan Panjwani; Fiscal Year: 2015
    ..In Aim 1, we will determine whether the function of select VEGF receptors (VEGFR-2 and -3) and integrins (1v23, 1v25, 1521, 1421, 1921, 1121), well- defined for their role in HA and/or LA, is ..
  56. Nanoparticles for Harvesting and Targeting Angiogenic Proteins
    Mauro Ferrari; Fiscal Year: 2010
    ..Refine conjugation of silicon nanoparticles to anti-VEGFR-2 receptor antibodies for selective targeting of endothelial cells in vitro and targeting tumor-associated blood ..
  57. Hong Chen; Fiscal Year: 2016
    ..Signaling by binding of vascular endothelial growth factor (VEGF) to its receptor VEGFR-2 is a major control point for angiogenesis...
  58. The Mechanisms of GM-CSF Inhibition of Breast Cancer Growth and Metastasis
    TIMOTHY EUBANK; Fiscal Year: 2009
    ..This decoy receptor is an alternately-spliced variant of the membrane-bound VEGFR-1 that binds and sequesters VEGF from biological activity...
  59. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    DAVID ALAN GREENBERG; Fiscal Year: 2013
    ..These effects are mediated largely through the VEGFR2 receptor, although we have also found that VEGFB, which acts via VEGFR1, has some of the same actions...
  60. Ultrasound Contrast Agents for Inflammation and Angiogenesis
    Joshua J Rychak; Fiscal Year: 2010
    ..treatment response will be compared against non-targeted MB (which quantify tumor blood flow) and a near-infrared VEGFR2 optical imaging contrast agent...
  61. Saulius Sumanas; Fiscal Year: 2015
    ..that the arterial- venous fate of EPCs is determined by the combination of etsrp-dependent timing of Vegf receptor flk1 and hyaluronan (HA) receptor stabilin 2 (stab2) expresion and their spatial location within Vegf gradient...
  62. THE ROLE OF VEGF ON PDPKD DISEASE PROGRESSION
    Yunxia Tao; Fiscal Year: 2010
    ..One of the central components of angiogenesis is the growth factor VEGF and its receptors VEGFR-1 and VEGFR-2...
  63. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
    ..In a proteomic search for potential mediators of eNOS activation, we identified vascular endothelial growth factor receptor 2 (VEGFR2) as being involved in laminar flow-induced eNOS activation...
  64. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..are to synthesize compounds to optimize inhibitory activity against vascular endothelial growth factor receptor-2 (VEGFR-2), against endothelial growth factor receptor (EGFR), against platelet-derived growth factor receptor-13 (PDGFR-[..
  65. Role of Protein Ubiquitination in Angiogenesis
    Nader Rahimi; Fiscal Year: 2010
    ..New pharmacologic therapies to target VEGFR-2 (vascular endothelial growth factor receptor-2) are currently being developed for treatment of several human ..
  66. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..of ethanol (10-100mM) primed HBMEC for the upregulation of vascular endothelial growth factor receptor-2 (VEGFR2 or KDR), resulting in increased cytotoxicity, permeability and intracellular Ca2+ in response to Tat...
  67. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2006
    ..we plan to determine the mechanism by which the expression of Vascular Endothelial Growth Factor-receptors, VEGFR2 (Flk-1, KDR), VEGFR1 (Flt-1) and VEGFR3 (Flt-4) orchestrate proliferation, mobilization and incorporation of BM-..