VEGF

Summary

Gene Symbol: VEGF
Description: vascular endothelial growth factor A
Alias: MVCD1, VEGF, VPF, vascular endothelial growth factor A, vascular endothelial growth factor A121, vascular endothelial growth factor A165, vascular permeability factor
Species: human

Top Publications

  1. ncbi Association between endometriosis and polymorphisms in endostatin and vascular endothelial growth factor and their serum levels in Korean women
    Jung Gu Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    Fertil Steril 89:243-5. 2008
  2. ncbi VEGF polymorphisms are associated with neovascular age-related macular degeneration
    Amanda J Churchill
    Molecular Ophthalmology, University of Bristol, and West Midlands Regional Genetics Laboratory, Birmingham Womans Hospital NHS Trust, UK
    Hum Mol Genet 15:2955-61. 2006
  3. ncbi Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    Rajnish A Gupta
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:906-11. 2003
  4. pmc Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
    Masabumi Shibuya
    Gakubunkan Institute of Physiology and Medicine, Jobu University, 270 1 Shinmachi, Takasaki, Gunma 370 1393, Japan
    J Biochem 153:13-9. 2013
  5. pmc The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis
    Anthony Lanahan
    Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA
    Dev Cell 25:156-68. 2013
  6. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  7. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
  8. pmc Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Development 141:556-62. 2014
  9. pmc Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site
    Saji Oommen
    Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 286:1083-92. 2011
  10. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007

Research Grants

  1. Sophia Ran; Fiscal Year: 2014
  2. Investigation of the VEGFR/Integrin cytoplasmic domains interaction.
    Olga Vinogradova; Fiscal Year: 2011
  3. GENETICS OF VEGF MEDIATED ANGIOGENESIS IN MOUSE SKIN
    Bruce J Herron; Fiscal Year: 2010
  4. Anti-angiogenesis of HC-HA Covalent Complex and PTX3 Purified from Fetal Membrane
    Scheffer C G Tseng; Fiscal Year: 2011
  5. Targeted photoacoustic imaging of VEGF receptors in angiogenic vasculature
    Joseph M Backer; Fiscal Year: 2011
  6. The connection between Notch signaling and VEGFR1 in angiogenesis
    HASINA HAMILTON OUTTZ; Fiscal Year: 2011
  7. Tatiana V Byzova; Fiscal Year: 2016
  8. Keratinocyte responses to vascular endothelial growth factor in carcinogenesis
    Traci A Wilgus; Fiscal Year: 2012
  9. Role of RPE-derived VEGF in Choroid Development and Stability
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
  10. JAMES FRANCIS MCGINNIS; Fiscal Year: 2015

Detail Information

Publications516 found, 100 shown here

  1. ncbi Association between endometriosis and polymorphisms in endostatin and vascular endothelial growth factor and their serum levels in Korean women
    Jung Gu Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    Fertil Steril 89:243-5. 2008
    ..the relationship between endometriosis and polymorphisms in the endostatin and vascular endothelial growth factor (VEGF) genes, and their levels in serum in a Korean population...
  2. ncbi VEGF polymorphisms are associated with neovascular age-related macular degeneration
    Amanda J Churchill
    Molecular Ophthalmology, University of Bristol, and West Midlands Regional Genetics Laboratory, Birmingham Womans Hospital NHS Trust, UK
    Hum Mol Genet 15:2955-61. 2006
    ..Linkage has been shown to the vascular endothelial growth factor (VEGF) gene and ocular levels of VEGF are raised in individuals with the neovascular form of disease...
  3. ncbi Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    Rajnish A Gupta
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:906-11. 2003
    ....
  4. pmc Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
    Masabumi Shibuya
    Gakubunkan Institute of Physiology and Medicine, Jobu University, 270 1 Shinmachi, Takasaki, Gunma 370 1393, Japan
    J Biochem 153:13-9. 2013
    ..b>VEGF-A, the major factor for angiogenesis, binds to two tyrosine kinase (TK) receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/..
  5. pmc The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis
    Anthony Lanahan
    Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA
    Dev Cell 25:156-68. 2013
    Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis...
  6. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  7. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
    b>Vascular endothelial growth factor A (VEGFA; hereafter referred to as VEGF) is a key regulator of physiological and pathological angiogenesis...
  8. pmc Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Development 141:556-62. 2014
    Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development...
  9. pmc Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site
    Saji Oommen
    Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 286:1083-92. 2011
    ..We have shown previously that it directly binds the vascular endothelial growth factors (VEGF) A, C, and D and contributes to VEGF-induced angiogenesis and lymphangiogenesis...
  10. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
    ..We also found the collaborative induction of vascular endothelial growth factor (VEGF) by HIF-1 and dysregulated c-Myc...
  11. doi Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration
    Takashi Tsuchihashi
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:93-100. 2011
    ..between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to treatment with photodynamic therapy (PDT) ..
  12. pmc Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    Iris M Heid
    Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany
    Nat Genet 42:949-60. 2010
    ..9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions...
  13. pmc A stress-responsive RNA switch regulates VEGFA expression
    Partho Sarothi Ray
    Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nature 457:915-9. 2009
    ..Here we report an RNA switch in human vascular endothelial growth factor-A (VEGFA, also known as VEGF) mRNA 3' untranslated region (UTR) that integrates signals from interferon (IFN)-gamma and hypoxia to regulate ..
  14. pmc Association between VEGF splice isoforms and progression-free survival in metastatic colorectal cancer patients treated with bevacizumab
    David O Bates
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Clin Cancer Res 18:6384-91. 2012
    ..The VEGF-A splice form, VEGF(165)b, anti-angiogenic in animal models, binds bevacizumab...
  15. pmc VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib
    M Scartozzi
    Department of Clinical Oncology, AOU Ospedali Riuniti, Polytechnic University of the Marche Region, Ancona, Italy
    Br J Cancer 108:1126-32. 2013
    ..We assessed the role of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) polymorphisms in the prediction of the clinical outcome in metastatic renal cell ..
  16. ncbi 15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expression
    Helena Viita
    Department of Biotechnology and Molecular Medicine, University of Kuopio, Finland
    Circ Res 102:177-84. 2008
    ..We used adenovirus-mediated gene transfers to study the effects of 15-LO-1 on vascular endothelial growth factor (VEGF)-A165- and placental growth factor (PlGF)-induced angiogenesis in rabbit skeletal muscles...
  17. pmc VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
    Birger Herzog
    BHF Laboratories, University College London, London WC1E 6JJ, UK
    Mol Biol Cell 22:2766-76. 2011
    In endothelial cells, neuropilin-1 (NRP1) binds vascular endothelial growth factor (VEGF)-A and is thought to act as a coreceptor for kinase insert domain-containing receptor (KDR) by associating with KDR and enhancing VEGF signaling...
  18. pmc Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
    R Mohle
    Developmental Hematopoiesis Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:663-8. 1997
    ..for secretion of cytokines, we evaluated megakaryocytic cells for secretion of vascular endothelial growth factor (VEGF)...
  19. ncbi A molecular cascade showing nitric oxide-heme oxygenase-1-vascular endothelial growth factor-interleukin-8 sequence in human endothelial cells
    Hyun Ock Pae
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Shinyoung dong, Iksan Shi, Chonbug 570 749, Republic of Korea
    Endocrinology 146:2229-38. 2005
    ..Interestingly, HO-1 tends to induce the production of vascular endothelial growth factor (VEGF) that is involved in endothelial IL-8 syntheses...
  20. pmc HIV-1 upregulates VEGF in podocytes
    Sonal Navin Korgaonkar
    Department of, New York, Mount Sinai School of Medicine, New York, USA
    J Am Soc Nephrol 19:877-83. 2008
    ..endothelial growth factor 164 (VEGF164) isoform also develop collapsing FSGS, we sought to determine whether VEGF plays a role in HIVAN...
  21. doi Serum vascular endothelial growth factor/soluble vascular endothelial growth factor receptor 1 ratio is an independent prognostic marker in pancreatic cancer
    Yu Ting Chang
    Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Pancreas 37:145-50. 2008
    ..sought to determine the role of pretreated serum angiogenic factors, including vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), in ..
  22. ncbi Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    Guilian Niu
    Immunology Program, H Lee Moffitt Cancer Center and Research Institute, Department of Oncology, University of South Florida College of Medicine, Tampa, Florida, FL 33612, USA
    Oncogene 21:2000-8. 2002
    ..tyrosine kinases, such as Src and EGF receptor (EGFR), are major inducers of vascular endothelial growth factor (VEGF), one of the most potent mediators of angiogenesis...
  23. pmc Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells
    Shumin Zhang
    Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Mol Cancer 9:9. 2010
    ..Mcl-1 overexpression has been associated with progression in leukemia and some solid tumors including prostate cancer (PCa). However, the regulatory mechanism for Mcl-1 expression in PCa cells remains elusive...
  24. pmc The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors
    Lokesh Jain
    Clinical Pharmacology Program, National Cancer Institute, Bethesda, Maryland, USA
    Mol Cancer Ther 8:2496-508. 2009
    Angiogenesis is crucial for development and metastasis of tumors, and vascular endothelial growth factor (VEGF) is a key mediator of this process...
  25. ncbi Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter
    Adam Stevens
    Endocrine Sciences Research Group, University of Manchester, Manchester M13 9PT, United Kingdom
    Cancer Res 63:812-6. 2003
    The human vascular endothelial growth factor (VEGF) gene is unusually polymorphic,and there is evidence for inheritance of conserved haplotypes...
  26. pmc Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis
    Keqiang Zhang
    Department of Clinical and Molecular Pharmacology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Mol Cancer 8:11. 2009
    ..Angiogenesis is critical to tumor malignancy; it plays an essential role in tumor growth and metastasis. It is important to investigate whether the angiogenic potential of tumor is affected by RRM2...
  27. pmc A systematic meta-analysis of genetic association studies for diabetic retinopathy
    Sotoodeh Abhary
    Department of Ophthalmology, Flinders Medical Centre and Flinders University, SA, Australia
    Diabetes 58:2137-47. 2009
    ..A systematic meta-analysis was undertaken to collectively assess genetic studies and determine which previously investigated polymorphisms are associated with diabetic retinopathy...
  28. doi miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells
    Sandra Cascio
    Section of Medical Oncology, Department of Surgical and Oncological Sciences, Palermo University, Palermo, Italy
    J Cell Physiol 224:242-9. 2010
    ..We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor (VEGF) in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions (CoCl(2) exposure)...
  29. doi Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma
    Clarissa Capp
    Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre HCPA, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Thyroid 20:863-71. 2010
    Vascular endothelial growth factor (VEGF-A) expression is upregulated in the majority of human tumors, where it stimulates proliferation, migration, and survival of endothelial cells...
  30. pmc Glucagon-like peptide-1 improves proliferation and differentiation of endothelial progenitor cells via upregulating VEGF generation
    Xie Xiao-Yun
    Department of Endocrinology, 3rd Xiangya Hospital, Central South University, Hunan Province, Changsha, China
    Med Sci Monit 17:BR35-41. 2011
    ..Vascular endothelial growth factor (VEGF) is an important cytokine in the process of EPCs vascular differentiation and proliferation.
  31. pmc The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation
    Bernhard Schweighofer
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, A 1090 Vienna, Austria E
    Thromb Haemost 102:544-54. 2009
    b>VEGF-A is the major trigger of vasculogenesis and physiologic angiogenesis...
  32. doi Increased risk of ovarian hyperstimulation syndrome following controlled ovarian hyperstimulation in patients with vascular endothelial growth factor +405 cc genotype
    Hans Ivar Hanevik
    Fertilitetsklinikken Sør, Telemark Hospital, Porsgrunn, Norway
    Gynecol Endocrinol 28:845-9. 2012
    ..Vascular endothelial growth factor (VEGF) and its receptor VEGFR2 have been identified as an important signaling system in mediating this increase...
  33. doi Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model
    Cinthia V Pastuskovas
    Genentech Research and Early Development, South San Francisco, California, USA
    Mol Cancer Ther 11:752-62. 2012
    Both human epidermal growth factor receptor 2 (HER-2/neu) and VEGF overexpression correlate with aggressive phenotypes and decreased survival among breast cancer patients...
  34. ncbi A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels
    W Renner
    Department of Internal Medicine, Division of Angiology, Karl Franzens University Graz, Graz, Austria
    J Vasc Res 37:443-8. 2000
    Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. Strong interindividual variations of VEGF plasma levels have been reported previously...
  35. ncbi Vascular endothelial growth factor assessment in different blood fractions of gastrointestinal cancer patients and healthy controls
    Girolamo Ranieri
    Interventional Radiology Unit, National Cancer Institute, Via Amendola 209, I 70126 Bari, Italy
    Oncol Rep 11:435-9. 2004
    Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis...
  36. doi Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells
    Salida Mirzoeva
    Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    Mol Carcinog 47:686-700. 2008
    ..Further, apigenin prevented the activation of the HIF-1 downstream target gene vascular endothelial growth factor (VEGF)...
  37. doi The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients
    Canan Ersoy
    Department of Endocrinology and Metabolism, Uludag University Medical School, 16059 Gorukle Bursa, Turkey
    Diabetes Res Clin Pract 81:56-60. 2008
    ..plasma glucose, hemoglobin A1C, plasminogen activator inhibitor-1 (PAI-1), vascular endothelial growth factor (VEGF) and increment in beta cell reserve values of the patients...
  38. pmc Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol BS2 8EJ, United Kingdom
    J Biol Chem 285:5532-40. 2010
    Vascular endothelial growth factor (VEGF) is produced either as a pro-angiogenic or anti-angiogenic protein depending upon splice site choice in the terminal, eighth exon...
  39. pmc Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
    Tom T Chen
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Cell Biol 188:595-609. 2010
    b>VEGF can be secreted in multiple isoforms with variable affinity for extracellular proteins and different abilities to induce vascular morphogenesis, but the molecular mechanisms behind these effects remain unclear...
  40. pmc Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells
    Hiroaki Shimoyamada
    Department of Pathology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Am J Pathol 177:70-83. 2010
    Vascular endothelial growth factor-A (VEGF-A) is crucial for angiogenesis, vascular permeability, and metastasis during tumor development...
  41. doi Gene expression profiling of fixed tissues identified hypoxia-inducible factor-1α, VEGF, and matrix metalloproteinase-2 as biomarkers of lymph node metastasis in hepatocellular carcinoma
    Zuo Lin Xiang
    Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
    Clin Cancer Res 17:5463-72. 2011
    ..Differential gene expression profiling is useful for investigating genes associated with lymph node metastasis (LNM). We screened genes to identify potential biomarkers for LNM in HCC...
  42. pmc Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis
    Hui Zheng
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 118:4003-6. 2011
    Angiogenesis is stimulated by vascular endothelial growth factor (VEGF) and antagonized by type 1 interferons, including IFN-α/β...
  43. doi Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression
    Peilin Cui
    Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    J Pineal Res 52:236-43. 2012
    ..It is well known that vascular endothelial growth factor (VEGF) plays key roles in tumor angiogenesis and has become an important target for antitumor therapy...
  44. doi Expression of vascular endothelial growth factor and vascular endothelial growth factor receptors 1 and 2 in invasive breast carcinoma: prognostic significance and relationship with markers for aggressiveness
    Hari Prasad Dhakal
    Department of Pathology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Histopathology 61:350-64. 2012
    Vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR-1) and VEGF receptor 2 (VEGFR-2) play a role in breast cancer growth and angiogenesis...
  45. pmc HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway
    Feng Zhou
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People s Republic of China
    PLoS ONE 8:e53145. 2013
    ..Tat promotes vIL-6-induced cell proliferation, cellular transformation, vascular tube formation and VEGF production in culture...
  46. pmc VEGF, HIF-1α expression and MVD as an angiogenic network in familial breast cancer
    Concetta Saponaro
    Functional Biomorphology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Bari, Italy
    PLoS ONE 8:e53070. 2013
    ..Expression of vascular endothelial growth factor (VEGF) is up-regulated during hypoxia by hypoxia-inducible factor-1α (HIF-1α)...
  47. pmc VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro
    Nicholas Beazley-Long
    Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Am J Pathol 183:918-29. 2013
    Vascular endothelial growth factor (VEGF) A is generated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b...
  48. ncbi Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy
    Caroline Bouzin
    Université Catholique de Louvain Medical School, Unit of Pharmacology and Therapeutics, Brussels, Belgium
    J Immunol 178:1505-11. 2007
    ..the tumor microenvironment, EC were exposed to TNF-alpha and the proangiogenic vascular endothelial growth factor (VEGF)...
  49. pmc Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis
    Cam T Ha
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Biol Reprod 83:27-35. 2010
    ....
  50. pmc Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors
    Anders Olsson
    Active Biotech AB, Box 724, 22007 Lund, Sweden
    Mol Cancer 9:107. 2010
    ..The array data were validated by real-time semiquantitative reversed transcriptase polymerase chain reaction (sqRT-PCR) and protein expression techniques...
  51. pmc P70S6K 1 regulation of angiogenesis through VEGF and HIF-1alpha expression
    Chuan xiu Bian
    Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Biochem Biophys Res Commun 398:395-9. 2010
    ..We found that knockdown of p70S6K1 significantly decreased VEGF protein expression and VEGF transcriptional activation through the HIF-1alpha binding site at its enhancer region...
  52. pmc Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3
    Thomas Neill
    Department of Pathology, Anatomy and Cell Biology, the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 287:5492-506. 2012
    ..Decorin evoked a reduction of hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor A (VEGFA) in MDA-231 breast carcinoma cells expressing constitutively-active HIF-1α...
  53. pmc Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1
    Matthew W Parker
    Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 287:11082-9. 2012
    Neuropilin-1 (Nrp1) is an essential receptor for angiogenesis that binds to VEGF-A. Nrp1 binds directly to VEGF-A with high affinity, but the nature of their selective binding has remained unclear...
  54. ncbi Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression
    L Hlatky
    Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts 02115
    Cancer Res 54:6083-6. 1994
    ..Thus, mammary stromal cells, only recently considered in the regulation of breast carcinomas, may play a hitherto unrealized role in breast cancer angiogenesis...
  55. ncbi Systemic production of vascular endothelial growth factor and fms-like tyrosine kinase-1 receptor in acute Kawasaki disease
    Kumi Yasukawa
    Department of Pediatrics, Kawasaki Seitetsu Hospital, Chiba, Japan
    Circulation 105:766-9. 2002
    Increased vascular permeability is an important event during the initial process of Kawasaki disease (KD). One potential responsible candidate for the induction of vascular hyperpermeability is vascular endothelial growth factor (VEGF).
  56. pmc Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19004, USA
    Mol Biol Cell 15:4841-53. 2004
    Increased expression of vascular endothelial growth factor (VEGF) contributes to the growth of many tumors by increasing angiogenesis...
  57. doi Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells
    Stefania Gessi
    Chair of Pharmacology, Faculty of Medicine, University of Ferrara, Department of Clinical and Experimental Medicine, Pharmacology Unit, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Arterioscler Thromb Vasc Biol 30:90-7. 2010
    ..As hypoxia induces HIF-1alpha stabilization and adenosine (ado) accumulation, we investigated whether this nucleoside regulates HIF-1alpha in FCs...
  58. doi A longitudinal study of plasma levels of soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF), sFlt1: PlGF ratio and vascular endothelial growth factor (VEGF-A) in normal pregnancy
    Maria Palm
    Department of Women s and Children s Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 90:1244-51. 2011
    To describe plasma levels of angiogenic (PlGF, VEGF-A) and anti-angiogenic (sFlt1) factors as well as the sFlt1:PlGF ratio throughout normal pregnancy and postpartum.
  59. doi Homozygosity for the +674C>T polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort
    Luciana N Almeida
    Department of Ophthalmology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190, Belo Horizonte, MG, Brasil 30130 100
    Graefes Arch Clin Exp Ophthalmol 250:185-9. 2012
    To investigate the association between VEGF gene polymorphism and age-related macular degeneration (AMD) in a Brazilian cohort.
  60. pmc Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
    Yasunori Shintani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    EMBO J 25:3045-55. 2006
    Neuropilin-1 (NRP1) is a co-receptor for vascular endothelial growth factor (VEGF) that enhances the angiogenic signals cooperatively with VEGFR2...
  61. ncbi Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    Ling Wang
    Department of Pathology, Beth Israel Deaconess Medical Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:48848-60. 2003
    ..has been found to be expressed by endothelial cells and tumor cells as an isoform-specific receptor for vascular permeability factor/vascular endothelial growth factor (VEGF)...
  62. ncbi Polymorphisms of KDR gene are associated with coronary heart disease
    Yibo Wang
    Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education, China
    J Am Coll Cardiol 50:760-7. 2007
    ..Our purpose was to determine whether the common polymorphisms (SNP-604, SNP1192, and SNP1719) in KDR are associated with risk of coronary heart disease...
  63. pmc Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1
    Maxime C Côté
    Cancer Research Center, Laval University, Quebec G1R 2J6, Canada
    J Biol Chem 285:8013-21. 2010
    ..pathway and that it regulates endothelial cell migration in response to vascular endothelial growth factor (VEGF). These conclusions are supported by a series of substantiating experiments...
  64. ncbi Vascular endothelial growth factor is a secreted angiogenic mitogen
    D W Leung
    Department of Molecular Biology, Genetech, South San Francisco, CA 94080
    Science 246:1306-9. 1989
    Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC)...
  65. pmc Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
    Yu wen Zhang
    Laboratory of Molecular Oncology, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 100:12718-23. 2003
    ..It is known that HGF/SF induces in vitro expression of vascular endothelial growth factor (VEGF), a key agonist of tumor angiogenesis; by contrast, thrombospondin 1 (TSP-1) is a negative regulator of ..
  66. ncbi Increased production of vascular endothelial growth factor in the lesions of atopic dermatitis
    Yan Zhang
    Department of Dermatology, School of Medicine, Shimane University, 89 1 Enya cho, Izumo, 693 8501, Shimane, Japan
    Arch Dermatol Res 297:425-9. 2006
    ..Vascular endothelial growth factor (VEGF) is a potent agent that causes hyperpermeability of blood vessels and endothelial cell proliferation, and might be ..
  67. doi Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss
    P J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    J Med Genet 46:300-7. 2009
    ..This paper examines other AMD susceptibility genes to determine if these genotypes influenced disease progression and treatment response...
  68. ncbi Expression of VEGF and its receptors in different brain tumors
    Hongguang Huang
    Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Neurol Res 27:371-7. 2005
    Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and -2 are considered to play a major in tumor angiogenesis, which is a prerequisite for growth of solid tumors...
  69. ncbi Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    S Soker
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:735-45. 1998
    Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1...
  70. ncbi VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells
    Jörg Fiedler
    Orthopaedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Biochem Biophys Res Commun 334:561-8. 2005
    Vascular endothelial growth factor (VEGF) has been indicated to play a role during endochondral ossification by stimulation of blood vessel invasion into hypertrophic cartilage resulting in its replacement by trabecular bone...
  71. ncbi Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis
    A Takahashi
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 54:4233-7. 1994
    The presence of mRNAs for vascular endothelial growth factor (VEGF) and a VEGF-related protein, placenta growth factor (PIGF) was examined in 29 cases of renal cell carcinoma tissues and adjacent normal kidney tissues and in 4 human renal ..
  72. ncbi Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and protein
    Tai Gen Cui
    Microvascula Research Laboratories, Dept of Physiology, Preclinical Veterinary School, Univ of Bristol, Southwell St, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 286:F767-73. 2004
    Despite production by podocytes of the proangiogenic molecule vascular endothelial growth factor-A (VEGF), the glomeruli are not sites of angiogenesis...
  73. doi Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
    Tomoya Kitamura
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Nat Cell Biol 10:329-37. 2008
    ..It is essential in vascular endothelial growth factor (VEGF)-mediated angiogenesis; however, it is not known how Akt regulates the migration of endothelial cells, a crucial ..
  74. doi Ovarian hyperstimulation syndrome is correlated with a reduction of soluble VEGF receptor protein level and a higher amount of VEGF-A
    D Pietrowski
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Hum Reprod 27:196-9. 2012
    ..The vascular endothelial growth factor (VEGF) system and its receptors have been identified as the main angiogenic factors responsible for increased capillary ..
  75. doi Bradykinin promotes vascular endothelial growth factor expression and increases angiogenesis in human prostate cancer cells
    Hsin Shan Yu
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    Biochem Pharmacol 87:243-53. 2014
    ..inflammatory mediator involved in tumor growth and metastasis, but its role in vascular endothelial growth factor (VEGF) expression and angiogenesis in human prostate cancer remains unknown...
  76. doi Increased angiogenesis induced by chronic lymphocytic leukemia B cells is mediated by leukemia-derived Ang2 and VEGF
    Rossana Maffei
    Hematology Unit, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy
    Leuk Res 34:312-21. 2010
    ..Our goal was to investigate: (i) the spontaneous and hypoxia-induced production of pro-angiogenic factors, VEGF and Ang2, by Real-time PCR and ELISA, (ii) the degree of vascularization in CLL-infiltrated bone marrow (BM) ..
  77. ncbi Intraocular VEGF level as a risk factor for postoperative complications after vitrectomy for proliferative diabetic retinopathy
    Yoshihiro Wakabayashi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 53:6403-10. 2012
    To investigate whether vitreous and aqueous humor concentrations of vascular endothelial growth factor (VEGF) predict postoperative complications after vitrectomy for proliferative diabetic retinopathy (PDR).
  78. ncbi Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients
    Dong Hwan Kim
    Department of Haematology Oncology, Kyungpook National University Hospital, Daegu, Korea
    Br J Haematol 140:71-9. 2008
    Increased angiogenesis, mediated by vascular endothelial growth factor (VEGF), was associated with poor prognosis in acute myeloid leukaemia (AML) patients...
  79. doi Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction
    C F Bento
    Center of Ophthalmology and Vision Sciences COCV IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Exp Physiol 95:955-70. 2010
    ..In this study, we hypothesize that increased levels of MGO disrupt the ratio of vascular endothelial growth factor (VEGF) to angiopoietin 2 (Ang 2) secreted by retinal pigment epithelial (RPE) cells, which provides a key destabilizing ..
  80. pmc Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
    Angiopoietins and their receptor Tie-2 are, in concert with VEGF-A, key mediators in angiogenesis...
  81. ncbi Functional polymorphisms in the vascular endothelial growth factor gene are associated with development of end-stage renal disease in males
    Kent Doi
    Department of Nephrology and Endocrinology, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, and Department of Nephrology and Kidney and Dialysis Center, Shonan Kamakura General Hospital, Kanagawa, Japan
    J Am Soc Nephrol 17:823-30. 2006
    This study elucidates the genetic role of vascular endothelial growth factor (VEGF) as a predisposing factor for progression of chronic kidney disease...
  82. ncbi Non-angiogenic functions of VEGF in breast cancer
    Arthur M Mercurio
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Mammary Gland Biol Neoplasia 10:283-90. 2005
    This review advances the hypothesis that the function of vascular endothelial growth factor (VEGF) in breast cancer is not limited to angiogenesis, and that VEGF signaling in breast carcinoma cells is important for the ability of these ..
  83. ncbi Platelets and vascular endothelial growth factor (VEGF): a morphological and functional study
    R Salgado
    Angiogenesis Group, Oncologic Centre, St Augustinus Hospital, Wilrijk, Belgium
    Angiogenesis 4:37-43. 2001
    ..Vascular Endothelial Growth Factor (VEGF) is one of the major positive regulators of tumour angiogenesis...
  84. pmc Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells
    Ling Fang He
    Immunology and Reproductive Biology Lab, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China
    J Biomed Sci 18:39. 2011
    ..Evidences suggest that STC-1 is associated with carcinogenesis and angiogenic process. However, it is unclear on the exact role for STC-1 in inducing angiogenesis and tumorigeneisis...
  85. doi VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients
    Tatjana Vlajnic
    Institute of Pathology, University Hospital Basel, Basel, Switzerland
    Mod Pathol 24:1404-12. 2011
    ..Further studies are needed to elucidate the potential role of amplification as a prognostic or predictive biomarker in both metastatic and nonmetastatic patients...
  86. doi Liquiritigenin inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signalling pathway in HeLa cells
    Si Rou Xie
    Department of Nutrition and Food Hygiene, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, P R China
    Phytother Res 26:1133-41. 2012
    ..Hypoxia-inducible factor-1α (HIF-1α) and its downstream target, vascular endothelial growth factor (VEGF), play a critical role in tumour angiogenesis and represent an attractive chemotherapeutic target...
  87. pmc The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer
    Vasundhra Kashyap
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Oncol 7:555-66. 2013
    ..We correlated LSD1 and JMJD2A expression with known mediators of prostate cancer progression: VEGF-A and cyclin A1...
  88. pmc Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy
    J M Jurgensmeier
    Translational Sciences, Oncology, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, UK
    Br J Cancer 108:1316-23. 2013
    The prognostic/predictive value of potential vascular endothelial growth factor (VEGF) signalling biomarkers was evaluated retrospectively using samples from two randomized Phase III studies (HORIZON II and III) investigating cediranib in ..
  89. pmc The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-β that activates profibrogenic genes in hepatic stellate cells
    Paresh Patel
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS ONE 9:e88934. 2014
    ..Besides its other roles in pathogenesis, Vpu is likely to contribute to hepatic fibrosis through this hitherto unknown mechanism. ..
  90. doi Polymorphisms in EGFR and VEGF contribute to non-small-cell lung cancer survival in a Chinese population
    Jing Dong
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China
    Carcinogenesis 31:1080-6. 2010
    ..The epidermal growth factor receptor (EGFR) and the vascular endothelium growth factor (VEGF) are two key targets...
  91. pmc Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells
    S Samuel
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Oncogene 30:1205-12. 2011
    Although the effects of vascular endothelial growth factor (VEGF) on angiogenesis and vascular function are well known, the effects of VEGF on tumor cell function remain to be elucidated...
  92. pmc VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart
    Jun Ming Tang
    Institute of Clinical Medicine Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, PR China
    Cardiovasc Res 91:402-11. 2011
    The objective of this study was to investigate whether vascular endothelial growth factor (VEGF) secreted by mesenchymal stem cells (MSC) improves myocardial survival and the engraftment of implanted MSC in infarcted hearts and promotes ..
  93. ncbi Correlation of Delta-like ligand 4 (DLL4) with VEGF and HIF-1α expression in human glioma
    Zhiqiang Li
    Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China
    Asian Pac J Cancer Prev 12:215-8. 2011
    ..glioma angiogenesis, we examined whether its expression correlates with that of vascular endothelial growth factor (VEGF) and hypoxia-induced factor-1α (HIF-1α)...
  94. pmc Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer
    Karl Deacon
    Centre for Respiratory Research, University of Nottingham, Nottingham, NG5 1PB, United Kingdom
    J Biol Chem 287:39967-81. 2012
    b>VEGF plays a central role in angiogenesis in cancer...
  95. doi Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis
    Shaohua Xu
    Changzhou Maternal and Child Health Hospital, Affiliated to Nanjing Medical University, Changzhou 213000, China
    Ann Hum Genet 76:464-71. 2012
    Published data on the association between the vascular endothelial growth factor (VEGF) gene -460C/T (rs833061), +405G/C (rs2010963), +936T/C (rs3025039) polymorphisms and endometriosis risk are inconclusive...
  96. doi VEGF -634G>C polymorphism and diabetic retinopathy risk: a meta-analysis
    Min Qiu
    Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan 430030, People s Republic of China
    Gene 518:310-5. 2013
    Vascular endothelial growth factor (VEGF), a multifunctional cytokine that promotes angiogenesis and is a potent mediator of microvascular permeability, which is critical for the development of diabetic retinopathy (DR)...
  97. doi Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway
    X Zhu
    1 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, PR China 2 Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, PR China 3 Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, PR China 4 Department of Laboratory Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, PR China
    Oncogene 33:1986-96. 2014
    ..These novel findings also suggest that targeting the PI3K/AKT signal may be a potentially effective therapeutic approach in AIDS-KS patients...
  98. doi Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies
    Y Z Li
    Department of Integrated Traditional Chinese and Western Medicine, Qilu Hospital, Shandong University, Jinan, China
    Genet Mol Res 12:1035-44. 2013
    ..Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF)...
  99. pmc The interplay between hypoxia, endothelial and melanoma cells regulates vascularization and cell motility through endothelin-1 and vascular endothelial growth factor
    Francesca Spinella
    Experimental Oncology Department, Regina Elena National Cancer Institute, 00144 Rome
    Carcinogenesis 35:840-8. 2014
    ..In all these cells, hypoxia enhanced ET-1 expression, which in turn induced vascular endothelial growth factor (VEGF)-A and VEGF-C secretion, through the hypoxia-inducible growth factor (HIF)-1α and HIF-2α...
  100. ncbi Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain
    Roni Mamluk
    Department of Surgical Research, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:24818-25. 2002
    Neuroplin-1 (NRP1), a receptor for vascular endothelial growth factor (VEGF) family members, has three distinct extracellular domains, a1a2, b1b2, and c...
  101. ncbi Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2
    Eli Geva
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0556, USA
    J Clin Endocrinol Metab 87:4213-24. 2002
    ..We investigated vascular endothelial growth factor (VEGF)-A, angiopoietin (Ang)-1 and -2 transcript profiles, and the protein products that they encode in placentas from ..

Research Grants96

  1. Sophia Ran; Fiscal Year: 2014
    ..are overexpressed in pro-lymphangiogenic breast tumor lines and act in concert with a VEGFR-3 specific ligand, VEGF-C156S, to synergistically induce LECs proliferation...
  2. Investigation of the VEGFR/Integrin cytoplasmic domains interaction.
    Olga Vinogradova; Fiscal Year: 2011
    ..During angiogenesis newly produced growth factors, including Vascular Endothelial Growth Factor (VEGF), initiate a series of intricate intracellular events which induce an "inside-out" signal that alters the ligand ..
  3. GENETICS OF VEGF MEDIATED ANGIOGENESIS IN MOUSE SKIN
    Bruce J Herron; Fiscal Year: 2010
    ..The Vascular Endothelial Growth Factors (VEGF) are a family of secreted glycoproteins that control angiogenesis...
  4. Anti-angiogenesis of HC-HA Covalent Complex and PTX3 Purified from Fetal Membrane
    Scheffer C G Tseng; Fiscal Year: 2011
    ..to produce a new class of angiogenesis inhibitors, which will not only suppress angiogenesis mediated by bFGF and VEGF but will also be more useful and effective by curtailing additional inflammation and scarring...
  5. Targeted photoacoustic imaging of VEGF receptors in angiogenic vasculature
    Joseph M Backer; Fiscal Year: 2011
    ..fluorescent dye indocyanine green on a dendrimer scaffold, and then conjugate the derivatized dendrimer to VEGF. We will test this tracer for photoacoustic imaging of VEGFR in the established model of tumor vascular remodeling ..
  6. The connection between Notch signaling and VEGFR1 in angiogenesis
    HASINA HAMILTON OUTTZ; Fiscal Year: 2011
    ..of angiogenesis and interacts with several other pathways, including that of vascular endothelial growth factor (VEGF)...
  7. Tatiana V Byzova; Fiscal Year: 2016
    ..Angiogenesis is driven by Vascular Endothelial Growth Factor (VEGF) and cell adhesion receptors, integrins on endothelial and blood cells...
  8. Keratinocyte responses to vascular endothelial growth factor in carcinogenesis
    Traci A Wilgus; Fiscal Year: 2012
    ..b>VEGF (vascular endothelial growth factor-A) is a potent pro-angiogenic factor, which has been implicated in a variety of ..
  9. Role of RPE-derived VEGF in Choroid Development and Stability
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
    The studies outlined in this proposal are aimed at understanding the role of VEGF in retinal pigment epithelium (RPE) - choriocapillaris interactions...
  10. JAMES FRANCIS MCGINNIS; Fiscal Year: 2015
    ..null retina by modulating the expression of many retinal genes including Vascular Endothelial Growth Factor (VEGF)...
  11. LENORE PALMA PEREIRA; Fiscal Year: 2016
    ..Vascular endothelial growth factors A and C (VEGF-A/C) upregulated in infected CTB could have paracrine effects on LEC functions in vivo...
  12. AKRIT SINGH SODHI; Fiscal Year: 2015
    ..g. vascular endothelial growth factor or VEGF), which, in turn, promote the growth of (leaky) blood vessels...
  13. Harriet M Kluger; Fiscal Year: 2015
    ..In preliminary studies using AQUA, we showed that RCCs with high levels of vascular endothelial growth factor (VEGF) receptors in tumor cells tend to have lower microvessel density and poor survival...
  14. Martin Friedlander; Fiscal Year: 2016
    ..in diseases like macular degeneration and diabetic retinopathy target vascular endothelial growth factor (VEGF) or its receptors...
  15. ANNE CHRISTINE EICHMANN; Fiscal Year: 2015
    ..We have shown that binding of the major lymphangiogenic growth factor VEGF-C to a Nrp2-VEGFR3 complex is critical for LEC sprouting...
  16. VEGF and PDGF in angiogenesis and tumor progression
    David A Cheresh; Fiscal Year: 2013
    ..During tumor angiogenesis, vascular endothelial growth factor (VEGF) and other angiogenic growth factors stimulate endothelial cells to sprout and form new vessels...
  17. Combination immunotherapies for the treatment of melanoma
    Michael W Fanger; Fiscal Year: 2013
    ..PV1 is among the top four most upregulated endothelial genes17, regulated by hypoxia8 and growth factors such as VEGF and HGF 8, 10, 19...
  18. Magdalena Chrzanowska; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Vascular endothelial growth factor (VEGF) is the critical factor responsible for blood vessel formation in normal conditions, such as in wound healing, and in pathological conditions, such as in tumor ..
  19. Vinay K Puduvalli; Fiscal Year: 2015
    ..Recently, bevacizumab, a humanized antibody that blocks vascular endothelial growth factor (VEGF) and prevents neoangiogenesis has shown efficacy against recurrent GBM and is approved for this indication...
  20. The Role of Vascular Flt-1 in Endothelial-Pericyte Interactions
    JOHN CHRISTOPHER CHAPPELL; Fiscal Year: 2013
    ..During development, endothelial cells respond differentially to vascular endothelial growth factor (VEGF)-A signaling to adopt phenotypes required for network expansion...
  21. Michael Simons; Fiscal Year: 2016
    ..The process is largely driven by vascular endothelial growth factor (VEGF) and results in formation of new arteries during embryonic development and in adult tissues...
  22. Kishore K Wary; Fiscal Year: 2016
    ..is a fundamental biological process that requires not only the action of vascular endothelial growth factor (VEGF) and the VEGF receptor-2 (VEGFR2) system, but also activation of the wingless (Wnt) pathway...
  23. Positive Role of MKP-1 in Angiogenesis.
    JOEL BOERCKEL; Fiscal Year: 2013
    ..this proposal is to characterize the role and mechanism of endothelial MKP-1 in vascular endothelial growth factor (VEGF)-induced angiogenesis in vitro by testing the hypothesis that MKP-1 positively mediates angiogenesis and regulates ..
  24. John P Cooke; Fiscal Year: 2014
    ..pathway is upregulated by hypoxia, and by other angiogenic factors such as the vascular endothelial growth factor (VEGF). Accordingly, we propose the following Specific Aims to develop a novel therapy for ROP: 1...
  25. STUART JAMES SHANKLAND; Fiscal Year: 2016
    ..Determine the role of pericyte-derived TIMP3 and ADAMTS1 in regulation of microvascular stability and VEGF receptor signaling Aim 3...
  26. Wenshe Liu; Fiscal Year: 2015
    ..diversities and screening these libraries to identify ligands specific for vascular endothelial growth factor (VEGF), a key target of antiangiogenic drugs...
  27. Targeted Modulation of Angiogenesis by VEGFR Peptidomimetic Antagonists
    Renata Pasqualini; Fiscal Year: 2012
    ..Currently approved therapies, directed against the central bodily chemical involved in angiogenesis, VEGF, are useful, but not entirely safe or effective...
  28. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..Another important mediator is vascular endothelial growth factor (VEGF), which induces the proliferation of sinusoidal endothelial cells and also stimulates stellate cells to produce HGF...
  29. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..which express soluble ectodomains of the Flkl and Fltl receptors for Vascular Endothelial Growth Factor (VEGF)...
  30. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
    ..Importantly, VEGFR2 activation by laminar flow occurs in a ligand-independent manner. It is well known that VEGF as a natural ligand stimulates VEGFR2 and induces an inflammatory response partially via NO production in EC...
  31. A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    APRIL FITZSIMMONS EICHLER; Fiscal Year: 2010
    ..Angiogenesis in solid tumors is driven by VEGF via the endothelial growth factor receptor, VEGFR2...
  32. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas E Vlahakis; Fiscal Year: 2010
    ..program will support investigations into the role of alpha9-beta1 integrin and vascular endothelial growth factors (VEGF) C and D in pulmonary lymphatic development and function...
  33. Therapeutic Angiogenesis for Erectile Dysfunction
    BRIAN ANNEX; Fiscal Year: 2009
    ..existing vascular structures and several angiogenic growth factors, including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), are present in corporal tissue...
  34. C Michael Hart; Fiscal Year: 2016
    ..caused by exposure to chronic hypoxia [unreadable] treatment with a vascular endothelial growth factor receptor (VEGF-R) antagonist...
  35. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..to that of the mammalian vascular system, where vascular sprouts expressing the vascular-endothelial growth factor (VEGF) receptor TK grow toward sources of VEGF...
  36. LOUIS CHARLES GERSTENFELD; Fiscal Year: 2015
    ..Other preliminary work from our laboratory has shown that while differentiated osteoblasts abundantly express VEGF(s), exogenously added VEGF(s) neither promote MSC osteogenic differentiation nor enhance differentiated osteoblast ..
  37. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..neuron specific enolase (NSE), astrocytic protein S100B, and ischemia marker vascular endothelial growth factor (VEGF) receptor 2...
  38. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..and in vitro angiogenesis in part through modulation of the expression of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor receptor-1 and the production of proangiogenic cytokines...
  39. Long Term Implications of Preeclampsia: Role of Obesity vs sFlt-1 Overexpression
    Egle Bytautiene; Fiscal Year: 2009
    ..The soluble Flt1 (sFlt1) is the soluble form of the vascular endothelial growth factor (VEGF) receptor 1, which binds VEGF and other angiogenic factors in the circulation, thereby decreasing their action...
  40. Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy
    Matthias Gromeier; Fiscal Year: 2010
    ..Preliminary studies of targeting the vascular endothelial growth factor (VEGF) receptor tyrosine kinases with our vector platform indicated potent anti-tumor effects in an aggressive syngeneic ..
  41. DANIEL J CARR; Fiscal Year: 2016
    ..Specifically, we have found a robust vascular endothelial growth factor (VEGF) A response by corneal epithelium infected with HSV-1 elicits lymphangiogenesis thru a VEGF receptor 2 (VEGFR2)-..
  42. Fabio A Recchia; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): In mammals, the vascular endothelial growth factor (VEGF) family consists of five members, VEGF-A, -B, -C, - D and placenta growth factor (PlGF), synthesized by various cell types, including ..
  43. Therapeutic Evaluation of Magnetic Nanoprobes Specific for Malignant Tumor Marker
    Rheal A Towner; Fiscal Year: 2010
    ..specific for tumor markers such as c-Met (tyrosine kinase receptor for the hepatocyte growth/scatter factor) or VEGF-R2 (vascular endothelial growth factor receptor), can be used therapeutically to inhibit or diminish glioma tumor ..
  44. Non-canonical VEGF receptor signaling regulates retinal neovascularization
    MICHAEL EDWIN BOULTON; Fiscal Year: 2012
    ..The collective evidence suggests that the vascular endothelial growth factor (VEGF) family is critical for ocular angiogensis and this has become a major target for therapeutic intervention...
  45. Novel multivalent/multifunctional agents derived from a humanized anti-insulin-li
    Thomas M Cardillo; Fiscal Year: 2010
    ..include cytokine therapy with IFN-a2b and PTK targeted therapies with anti-vascular endothelial growth factor (VEGF) receptor antibodies or mammalian target of rapamycin (mTOR) inhibitors, such as temsirolimus...
  46. Ali Syed Arbab; Fiscal Year: 2016
    ..GBM are characterized by release of vascular endothelial growth factor (VEGF), an important regulator and promoter of new vessel formation (angiogenesis) and vascular permeability...
  47. Quantitative Biomarker Imaging for Early Therapy Response Assessment in Cancer
    James M Mountz; Fiscal Year: 2013
    ..against epidermal growth factor receptor (EGFR) and angiogenesis, including vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR)...
  48. Placental Insufficiency in Transgenic Mouse Model of Preeclampsia and IUGR
    TERRY KNUD MORGAN; Fiscal Year: 2013
    ..with preeclampsia and/or IUGR demonstrate upregulation of placental s-flt1 (vascular endothelial growth factor [VEGF] receptor), a sign of relative ischemia, and months before the clinical presentation of these diseases...
  49. Debabrata Mukhopadhyay; Fiscal Year: 2014
    ..by applicant): The long-term objective of our proposal is to elucidate the signaling pathways by which vascular permeability factor/vascular endothelial growth factor (VPF/VEGF, VEGF-A) promotes blood vessel formation and influences ..
  50. Tracy T Batchelor; Fiscal Year: 2016
    ..A pathophysiological hallmark of glioblastoma (GBM) is the expression of vascular endothelial growth factor (VEGF) and other pro-angiogenic cytokines, which, in turn, stimulate endothelial cell proliferation, migration and ..
  51. VEGF regulation of neurogenesis
    DIANE CATHERINE DARLAND; Fiscal Year: 2011
    ..The goal of the proposed research is to investigate the role of vascular endothelial growth factor A (VEGF) and its mechanism of action in regulating early cortical neurogenesis...
  52. Wensheng Lin; Fiscal Year: 2015
    ..global protein biosynthesis, but stimulates the expression of certain stress-induced genes, such as vascular endothelial growth factor A (VEGF), by phosphorylating translation initiation factor 21 (eIF21)...
  53. H Scott Baldwin; Fiscal Year: 2016
    ..Along with the vascular endothelial growth factor (VEGF) receptor, these are the only known endothelial cell-specific RTKs...
  54. VEGFR-2 Targeted Imaging
    Zhen Cheng; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Vascular endothelial growth factor (VEGF) receptors VEGFR-1 (FLT-1) and VEGFR-2 (KDR/Flk-1) are prime targets for anti-angiogenic therapeutics because they are up-regulated on tumor vascular ..
  55. COMBINED ULTRASOUND/MOLECULAR ANALYSIS OF TUMOR RESPONSE TO VEGF BLOCKADE
    Jessica J Kandel; Fiscal Year: 2010
    ..have recently reported Phase I data indicating excellent tolerance of the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab (BV) in refractory pediatric tumors...
  56. Spatial Monte Carlo models for VEGF binding on the cell membrane
    ADAM MIKLOS HALASZ; Fiscal Year: 2012
    Vascular endothelial growth factor (VEGF) signaling controls blood vessel development and plays a central role in the vascularization of malignant tumors...
  57. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
    ..Signaling via vascular endothelial growth factor (VEGF) plays a vital role in tumor angiogenesis...
  58. David M Briscoe; Fiscal Year: 2016
    ..provided by applicant): This project is based on the observation that Vascular Endothelial Growth Factor (VEGF) is overexpressed within allografts in association with ischemia-reperfusion, humoral immunity and acute and ..
  59. Potential target molecules for ischemic retinopathies
    GERARD ANTHONY LUTTY; Fiscal Year: 2011
    ..These molecules include vascular endothelial growth factor (VEGF) and its receptors, placental growth factor (PIGF), and tumor necrosis factor-a (TNFa)...
  60. Rupal S Bhatt; Fiscal Year: 2014
    ..While these inhibitors of vascular endothelial growth factor (VEGF) driven angiogenesis have impressive clinical activity, the response to these agents is finite with resistance ..
  61. Aleksander S Popel; Fiscal Year: 2016
    ..experimental measurements will similarly be conducted at multiple scales, using vascular endothelial growth factor (VEGF) and the VEGF receptors, viable targets for the modulation of therapeutic angiogenesis, from the molecular to the ..
  62. VEGF blockade and alternative angiogenic pathways in neuroblastoma
    Darrell J Yamashiro; Fiscal Year: 2012
    ..One validated anti-angiogenic target is vascular endothelial growth factor (VEGF), which is expressed in essentially all human cancers, including neuroblastoma...
  63. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: A Phase II Randomized Study to Compare Anti-VEGF Agents in the Treatment of Diabetic Macular Edema (CADME) Number: 12-EI-0134 Background: - Diabetic macular edema ..
  64. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: A Phase II Randomized Study to Compare Anti-VEGF Agents in the Treatment of Diabetic Macular Edema (CADME) Number: 12-EI-0134 Background: - Diabetic macular edema ..
  65. Modeling preeclampsia in mice with inducible placenta-specific gene expression
    Nihar R Nayak; Fiscal Year: 2012
    ..and clinical manifestations of the disease through its antagonism of vascular endothelial growth factor (VEGF) activity...
  66. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ..NTF: brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) in the large, middle-aged to elderly, community-based, Framingham Heart Study (FHS) Original, Offspring and Omni ..
  67. Souheil El-Chemaly; Fiscal Year: 2014
    ..Vascular endothelial growth factor (VEGF)-C mutated at residue 156 (VEGF-C C156S) has been shown to induce lymphangiogenesis and not angiogenesis...
  68. Role of Protein Ubiquitination in Angiogenesis
    Nader Rahimi; Fiscal Year: 2010
    ..It is widely accepted that the angiogenic switch is OFF when the effect of pro-angiogenic molecules such as VEGF and its receptor, VEGFR-2 is balanced by that of anti-angiogenesis molecules, and is ON when the net balance is ..
  69. Reza Dana; Fiscal Year: 2016
    ..blood vessels and lymphatics in mediating cell trafficking, and the function of pro-lymphangiogenic mediators, VEGF-C, VEGF-D, and VEGFR-3, in regulating APC maturation and function...
  70. Kaustubh Datta; Fiscal Year: 2014
    ..A number of publications have demonstrated an increase in expression of vascular endothelial growth factor-C (VEGF-C) in metastatic prostate cancer when compared to primary prostate cancer...
  71. JENS MARC TITZE; Fiscal Year: 2016
    ..Our data point to macrophage-derived vascular endothelial growth factor C (VEGF-C) as a crucial factor controlling skin electrolyte homeostasis...
  72. E2F1 in Cardiac Neovascularization
    Gangjian Qin; Fiscal Year: 2013
    ..observed in E2F1-deficient mice appears to be the overproduction of vascular endothelial growth factor (VEGF), and E2F1 suppresses the transcription of VEGF;C) Oncogene p53 may also play a role in this E2F1- mediated hypoxic ..
  73. VEGFs in tumor lymphatic metastasis
    HAROLD FISHER DVORAK; Fiscal Year: 2012
    ..While we know a little bit about the VEGF family members that stimulate lymphangiogensis, there is still much we don't know...
  74. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2013
    ..The vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) are critical elements of the tightly regulated balance of endogenous ..
  75. Therapeutic Lymphatic Collecting Vessel Regeneration by Directed Fluid Flow
    Jeremy Goldman; Fiscal Year: 2012
    ..Because delivery of excess vascular endothelial growth factor (VEGF)- C to the human may produce harmful side effects, we will investigate Nitric Oxide (NO) release from the ..
  76. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..In addition to the role for GIT1 in VSMC, we found that GIT1 mediated EC permeability and signaling by VEGF further defining the importance of GIT1 in vascular biology...
  77. Downregulation of Rod Metabolism in Retinopathy of Prematurity
    JAMES DANIEL AKULA; Fiscal Year: 2010
    ..to supplement these measures and to evaluate the expression of neurogenic and angiogenic growth factors such as VEGF, PEDF and semaphorins...
  78. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..we showed that CRH activates mast cells through CRHR-1 leading to release of vascular endothelial growth factor (VEGF), increased vascular permeability and blood-brain-barrier (BBB) disruption...
  79. Emilio B Gonzalez; Fiscal Year: 2014
    ..adhesion molecule-1 (VCAM-1), upregulation of cytokines [IL1b, IL6, IL8, TNF-a, vascular endothelial growth factor (VEGF)]...
  80. Sharon M Moe; Fiscal Year: 2014
    ..such as zoledronic acid also inhibit angiogenesis through down regulation of vascular endothelial growth factor (VEGF). VEGF levels are elevated in CKD patients and associated with increased mortality...
  81. Anti-angiogenic Barriers to Tumor Development
    Susan E Crawford; Fiscal Year: 2010
    ..These changes were associated with activated hepatic stellate cells and increased levels of angiogenic inducers, VEGF, and leptin in the PEDF null liver...
  82. Rashmi S Hegde; Fiscal Year: 2016
    ..treated with laser-mediated ablation of the retina, and more recently with intraocular administration of anti-VEGF antibodies;however, neither of these treatment options is without limitations...
  83. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..growth factor-1 (IGF-1), glial derived neurotrophic factor (GDNF), and vascular endothelial growth factor (VEGF) delivered at disease onset in ALS rodent models have demonstrated profound effects in delaying disease progression...
  84. A Novel Model to Study Retinopathy of Prematurity
    David Moscatelli; Fiscal Year: 2003
    ..Much attention has focused on the possible role of the vascular endothelial growth factor, VEGF-A, in the development of this disease...
  85. Bone Tissue Engineerig: Effect of Dynamic Perfusion
    Aaron Goldstein; Fiscal Year: 2009
    ..osteogenic factor bone morphogenetic protein (BMP)-2 and the angiogenic factor vascular endothelial growth factor (VEGF)-A are induced by perfusion, and that BMP-2 expression in particular is sensitive to pulsatile perfusion...
  86. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2001
    ..Vascular endothelial growth factor (VEGF), a potent hypoxia-inducible angiogenic cytokine, has been implicated causally in retinal NV suggesting that VEGF ..
  87. Role of VEGF in Glomerular Endothelial Health & Diseases
    S Karumanchi; Fiscal Year: 2007
    ..It has been shown that vascular endothelial growth factor (VEGF) is not only an essential molecule for glomerulogenesis and kidney development, but also important for glomerular ..
  88. Signaling mechanisms underlying VEGF-induced neuroprotection in vivo
    Susan Croll; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Vascular endothelial growth factor (VEGF) is a vascular growth factor recently shown to have neuroprotective effects both in vitro and in vivo...
  89. Statins and VEGF-induced cytoskeletal remodeling
    FARHAD DANESH; Fiscal Year: 2009
    ..we hypothesize that statins may attenuate the detrimental effects of vascular glomerular endothelial growth factor (VEGF) in diabetic nephropathy...
  90. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Project Summary VEGF (Vascular Endothelial Growth Factor) is one of the main angiogenic factors involved in the development and maintenance of blood vessels and is shown to play a central role in ..
  91. Cyclic Follicle Function and Angiogenesis
    Ralf Zimmermann; Fiscal Year: 2006
    ..provided by applicant): The most important regulator of angiogenesis is vascular endothelial growth factor (VEGF), which acts mostly through two receptors: VEGF receptor 1 (VEGF-R1) and 2 (VEGF-R2)...
  92. Effects of VEGF on Brain Tissue in vitro
    JEFFREY ROSENSTEIN; Fiscal Year: 2004
    Vascular endothelial growth factor (VEGF) is a secreted growth factor that plays an important regulatory role in vascular development...
  93. REACTIVE ASTROGLIA--INFLUENCES ON CNS GRAFTS AND WOUNDS
    JANETTE KRUM; Fiscal Year: 2002
    ..astrocytes are an endogenous source of endothelial growth factors, including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and thus can influence the rate of wound vascularization which ..
  94. Diabetic Albuminuria and VEGF and Nephrin
    Sheldon Chen; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): [unreadable] Vascular endothelial growth factor (VEGF)-dependent albuminuria has been demonstrated in animal models of both type 1 and type 2 diabetes (de Vriese, JASN 2001 and Flyvbjerg, ..
  95. Signaling Mechanisms of VEGF Receptor in Vasculogenesis
    Guo Hua Fong; Fiscal Year: 2004
    DESCRIPTION: (provided by applicant): The vascular endothelial growth factor-A (VEGF-A, or VEOF) and its receptors play critical roles in controlling blood vessel growth and function, such as embryonic vascularization and tumor ..
  96. VEGF PROTECTS AGAINST PULMONARY VASCULAR REMODELING
    Rubin Tuder; Fiscal Year: 2001
    ..The lung contains abundant Vascular Endothelial Growth Factor (VEGF), which is a key regulatory molecule involved in the growt and differentiation of endothelial cells...