UTS2

Summary

Gene Symbol: UTS2
Description: urotensin 2
Alias: PRO1068, U-II, UCN2, UII, urotensin-2, prepro U-II, urotensin II
Species: human

Top Publications

  1. pmc Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord
    Y Coulouarn
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, Recherche Scientifique, University of Rouen, 76821 Mont Saint Aignan, France
    Proc Natl Acad Sci U S A 95:15803-8. 1998
  2. ncbi Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
    R S Ames
    Department of Molecular Biology, Smith Kline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Nature 401:282-6. 1999
  3. ncbi Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
    Q Liu
    Department of Human Genetics, Merck Research Laboratories, WP26A 3000, West Point, Pennsylvania, 19486, USA
    Biochem Biophys Res Commun 266:174-8. 1999
  4. ncbi Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues
    M Matsushita
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Hypertens 19:2185-90. 2001
  5. ncbi Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure
    Melissa Lim
    National Health and Medical Research Council of Australia Centre of Clinical Research Excellence in Therapeutics, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Circulation 109:1212-4. 2004
  6. ncbi Plasma concentration of urotensin II is raised in hypertension
    Bernard M Y Cheung
    University Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    J Hypertens 22:1341-4. 2004
  7. ncbi Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese
    Susumu Suzuki
    Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Peptides 25:1803-8. 2004
  8. ncbi Proliferation and anti-apoptotic effects of human urotensin II on human endothelial cells
    Libin Shi
    Division of Cardiology, Department of Internal Medicine, Peking University First Hospital, Xishiqudaji 8, West District, Beijing 100034, China
    Atherosclerosis 188:260-4. 2006
  9. ncbi Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Peptides 27:1659-67. 2006
  10. pmc The role of urotensin II in cardiovascular and renal physiology and diseases
    Yi Chun Zhu
    Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai, China
    Br J Pharmacol 148:884-901. 2006

Research Grants

  1. CRF System and Methamphetamine Extinction
    Andrey E Ryabinin; Fiscal Year: 2010
  2. Modulation of Dopaminergic VTA Neurons by Urotensin II
    STEWART DONALDSON CLARK; Fiscal Year: 2010
  3. Novel Urotensin II Antagonists
    AJAY REGE; Fiscal Year: 2005
  4. Universal Influenza A Vaccine
    Ashley Birkett; Fiscal Year: 2004
  5. The hypocretins and alcohol dependence
    Luis de Lecea; Fiscal Year: 2003
  6. NEUROPEPTIDE CORTISTATIN AND SLEEP
    Luis de Lecea; Fiscal Year: 2006
  7. Hypocretin and Drug Addiction
    Luis de Lecea; Fiscal Year: 2010
  8. NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIA
    Andrey Ryabinin; Fiscal Year: 2001
  9. Perioculomotor area and alcohol
    Andrey E Ryabinin; Fiscal Year: 2010
  10. ROLE OF UROCORTIN IN MAMMALIAN BRAIN AND PITUITARY
    AUDREY SEASHOLTZ; Fiscal Year: 2004

Detail Information

Publications210 found, 100 shown here

  1. pmc Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord
    Y Coulouarn
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, Recherche Scientifique, University of Rouen, 76821 Mont Saint Aignan, France
    Proc Natl Acad Sci U S A 95:15803-8. 1998
    b>Urotensin II (UII) is a cyclic peptide initially isolated from the caudal neurosecretory system of teleost fish...
  2. ncbi Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
    R S Ames
    Department of Molecular Biology, Smith Kline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Nature 401:282-6. 1999
    ..Furthermore, as U-II immunoreactivity is also found within central nervous system and endocrine tissues, it may have additional activities...
  3. ncbi Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
    Q Liu
    Department of Human Genetics, Merck Research Laboratories, WP26A 3000, West Point, Pennsylvania, 19486, USA
    Biochem Biophys Res Commun 266:174-8. 1999
    b>Urotensin II (UII) is a neuropeptide with potent cardiovascular effects. Its sequence is strongly conserved among different species and has structural similarity to somatostatin...
  4. ncbi Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues
    M Matsushita
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Hypertens 19:2185-90. 2001
    Urotensin-II (UII), a cyclic dodecapeptide originally isolated from fish urophysis that has potent cardiovascular effects, has recently been identified as an endogenous ligand for the orphan G protein-coupled receptor, GPR14...
  5. ncbi Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure
    Melissa Lim
    National Health and Medical Research Council of Australia Centre of Clinical Research Excellence in Therapeutics, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Circulation 109:1212-4. 2004
    b>Urotensin II (U-II) is a novel vasoactive peptide that also has direct hypertrophic and profibrotic effects on the myocardium...
  6. ncbi Plasma concentration of urotensin II is raised in hypertension
    Bernard M Y Cheung
    University Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    J Hypertens 22:1341-4. 2004
    b>Urotensin II is the most potent vasoconstrictor known. Its role in hypertension has not been investigated. Here, we studied the plasma levels in hypertensive and normotensive human subjects.
  7. ncbi Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese
    Susumu Suzuki
    Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Peptides 25:1803-8. 2004
    b>Urotensin II is among the most potent vasoactive hormones known and the urotensin II (UTS2) gene is localized to 1p36-p32, one of the regions reported to show possible linkage with type 2 diabetes in Japanese...
  8. ncbi Proliferation and anti-apoptotic effects of human urotensin II on human endothelial cells
    Libin Shi
    Division of Cardiology, Department of Internal Medicine, Peking University First Hospital, Xishiqudaji 8, West District, Beijing 100034, China
    Atherosclerosis 188:260-4. 2006
    Human urotensin II (hU-II) is a potent vasoconstrictor, highly expressed in cardiac tissues and blood vessels. Recent studies indicate that hU-II participates in vascular and myocardial remodeling after injury...
  9. ncbi Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Peptides 27:1659-67. 2006
    We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to ..
  10. pmc The role of urotensin II in cardiovascular and renal physiology and diseases
    Yi Chun Zhu
    Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai, China
    Br J Pharmacol 148:884-901. 2006
    b>Urotensin II (U-II) is a cyclic neuropeptide that was first isolated from teleost fish some 35 years ago. Mammalian U-II is a powerful vasoconstrictor with a potency greater than that of endothelin-1...
  11. ncbi Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China
    L Yi
    School of Life Science, Lanzhou University, Lanzhou City, Gansu Province, China
    J Int Med Res 34:272-83. 2006
    ..polymorphisms of the genes for angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2) and urotensin II (UTS2) as risk factors for essential hypertension in two populations from north-western China, we enrolled 198 ..
  12. ncbi Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors
    Kohta Nishihama
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, Japan
    Int J Mol Med 19:129-41. 2007
    ..T of GP1BA, -108/3Gright curved arrow 4G of IPF1, 677Cright curved arrow T of MTHFR, and Gright curved arrow A of UTS2 in hypertensive individuals; 2445Gright curved arrow A of FABP2, -108/3Gright curved arrow 4G of IPF1, 677Cright ..
  13. ncbi Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Peptides 29:873-80. 2008
    b>Urotensin II (UII), first identified from goby urophysis, is a potent vasoactive peptide hormone and an endogenous ligand for an orphan G protein-coupled receptor GPR14, now named urotensin II receptor (UT-R)...
  14. doi Pro-angiogenic activity of Urotensin-II on different human vascular endothelial cell populations
    Giovanna Albertin
    Department of Human Anatomy and Physiology Section of Anatomy, University of Padova Medical School, Via Gabelli, 65 I 35121 Padova, Italy
    Regul Pept 157:64-71. 2009
    ..Overall, these data suggest that U-II, in addition to the well known role in the regulation of cardiovascular function, also exert a specific angiogenic activity...
  15. doi Urotensin II immunoreactivity in the human circulation: evidence for widespread tissue release
    Yen Hsing Chen
    Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago, Christchurch 8140, New Zealand
    Clin Chem 55:2040-8. 2009
    The sources of secretion and clearance of plasma urotensin II (UII) in the human circulation remain uncertain and may be relevant to understanding the role of UII in human physiology and cardiovascular disease.
  16. doi Raised plasma urotensin II in type 2 diabetes patients is associated with the metabolic syndrome phenotype
    Damien Gruson
    Endocrinology and Nutrition Unit, Universite Catholique de Louvain, Tour Claude Bernard, 54 Avenue Hippocrate, Brussels, Belgium
    J Clin Hypertens (Greenwich) 12:653-60. 2010
    b>Urotensin II (UII) exerts multiple effects on the cardiovascular system, acts as a diabetogenic agent, and may also contribute to the development of the metabolic syndrome (MetS)...
  17. pmc Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance
    Maria E Saez
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    PLoS ONE 6:e19327. 2011
    b>Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR)...
  18. ncbi [The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population]
    Fang Zhu
    Department of Endocrinology and Metabolism, People s Hospital of Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 82:1473-5. 2002
    To investigate the relationship between the polymorphism of site rs228648 in urotensin II gene and the genetic susceptibility to type 2 diabetes in Han people.
  19. ncbi Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects
    Z Wenyi
    Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Diabetologia 46:972-6. 2003
    b>Urotensin II is a potent vasoactive hormone and the urotensin II gene (UTS2) is localized to 1p36-p32, one of the regions reported to show possible linkage with Type 2 diabetes in Japanese subjects...
  20. ncbi [The association of two single nucleotide polymorphisms in PRKCZ and UTS2 respectively with type 2 diabetes in Han people of northern China]
    Hong xia Sun
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:223-7. 2002
    ..To probe the candidate susceptibility gene (s) of type 2 diabetes in the formal mapping region, 1p36.33-p36.23, in Han people of Northern China using single nucleotide polymorphisms (SNPs)...
  21. ncbi Renal and vascular actions of urotensin II
    N Ashton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Kidney Int 70:624-9. 2006
    The peptide hormone urotensin II (UII) has been highly conserved through the vertebrates from fish to humans...
  22. ncbi [Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women]
    Yu Jie Tan
    Department of Obstetrics and Gynecology, First Hospital of Peking University, Beijing 100034, China
    Zhonghua Fu Chan Ke Za Zhi 41:732-5. 2006
    To investigate the relationship between the polymorphism of site rs228648 in urotensin II gene and the genetic susceptibility to gestational diabetes mellitus in northern Chinese women.
  23. doi Effect of urotensin II on skin microvessel tone in diabetic patients without heart failure or essential hypertension
    E Zomer
    NHMRC Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventative Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:1147-50. 2008
    b>Urotensin II (UII) is a potent vasoconstrictor peptide. Increased plasma levels and kidney expression of UII and its receptor have been observed in diabetes mellitus (DM)...
  24. ncbi Association between urotensin II gene polymorphism and pre-eclampsia
    Ebru Dikensoy
    Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, Turkey
    Eur J Obstet Gynecol Reprod Biol 151:140-2. 2010
    To investigate the association of a specific polymorphism (S89N) in exon 3 of the urotensin II (UTS2) gene in pre-eclampsia.
  25. ncbi Seasonal changes in peptide, receptor and ion channel mRNA expression in the caudal neurosecretory system of the European flounder (Platichthys flesus)
    Weiqun Lu
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Gen Comp Endocrinol 153:262-72. 2007
    ..Expression levels of mRNA for peptides urotensins I and II (UI, UII) and corticotropin releasing factor (CRF) all showed a seasonal cycle, with lowest expression in April and highest ..
  26. ncbi Caudal neurosecretory system of the zebrafish: ultrastructural organization and immunocytochemical detection of urotensins
    C Parmentier
    Laboratory of Neurobiology of Intercellular Signals, UMR CNRS 7101, University Paris VI, Paris, France
    Cell Tissue Res 325:111-24. 2006
    ..Dahlgren cells and the urophysis, together with the immunohistochemical localization of urotensin I and II (UI and UII) peptides. Two latero-ventral bands of neuronal perikarya in the caudal spinal cord project axons to the urophysis...
  27. ncbi Nitric oxide and neuromodulation in the caudal neurosecretory system of teleosts
    Carla Cioni
    Department of Animal and Human Biology, La Sapienza University, via A Borelli 50, 00161 Rome, Italy
    Comp Biochem Physiol B Biochem Mol Biol 132:57-68. 2002
    ..Moreover, the comparison of the nNOS distribution with that of urotensins I and II (UI and UII) suggests that neurosecretory Dahlgren cells belong to two different functional subpopulations: a population of UI/..
  28. ncbi Peptide hormones influence in vitro interrenal secretion of cortisol in the trout, Oncorhynchus mykiss
    D E Arnold-Reed
    School of Biological Sciences, University of Manchester, United Kingdom
    Gen Comp Endocrinol 96:85-91. 1994
    Adrenocorticotrophic hormone (ACTH), angiotensin II (AII), and the urophysial peptides, urotensins I and II (UI and UII), stimulate cortisol secretion by interrenal preparations of seawater (SW) and freshwater (FW) adapted trout...
  29. ncbi Common and divergent structural features of a series of corticotropin releasing factor-related peptides
    Christy Rani R Grace
    Structural Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 129:16102-14. 2007
    ..urotensins, and urocortin 1 (Ucn1), which bind to both the CRF receptors CRF-R1 and CRF-R2, and the urocortins 2 (Ucn2) and 3 (Ucn3), which are selective agonists of CRF-R2...
  30. pmc Urotensin I-CRF-Urocortins: A mermaid's tail
    Quentin J Pittman
    Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, Calgary, AB, Canada T2N 4N1 Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada T2N 4N1
    Gen Comp Endocrinol 164:7-14. 2009
    ..relevant to the discovery of Urotensin I (UI) in the Lederis laboratory, along with the concurrent discovery of Urotensin II (UII) in the Bern laboratory and corticotropin-releasing factor (CRF/CRH) in the Vale laboratory...
  31. ncbi Colocalization of neuronal NO synthase with urotensins I and II in the caudal neurosecretory neurons and the urophysis of the teleost oreochromis niloticus: a gold immunoelectron microscopic study
    C Cioni
    Department of Animal and Human Biology, La Sapienza University, Rome, Italy
    Brain Behav Evol 56:86-93. 2000
    ..Double immunogold labelings for nNOS/urotensin I (UI) and nNOS/urotensin II (UII) demonstrated that nNOS-like molecules are colocalized with UI and/or UII in the neurosecretory granules ..
  32. doi The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices
    Yoko Kawaguchi
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Anesth Analg 108:1177-81. 2009
    b>Urotensin II (UII) and its receptor (UT) are implicated in mood disorders, such as stress and anxiety, and this may result, at least in part, from increased norepinephrine release from the cerebral cortex...
  33. ncbi [Expressions of urotensin II and its receptor in pulmonary arteries in rats with chronic thromboembolic pulmonary hypertension]
    Yi mei Zhang
    Department of Respiratory Medicine, The First Hospital of Harbin Medical University, Harbin 150001, China
    Zhonghua Jie He He Hu Xi Za Zhi 31:37-41. 2008
    To investigate the expressions of Urotensin II (UII) protein and mRNA and its receptor (UT) mRNA of medium and small pulmonary arteries of rats with chronic thromboembolic pulmonary hypertension.
  34. doi New insight into the molecular evolution of the somatostatin family
    Herve Tostivint
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, University of Rouen, 76821 Mont Saint Aignan, France
    Mol Cell Endocrinol 286:5-17. 2008
    ..review describes the molecular evolution of the somatostatin family and its relationships with that of the urotensin II family...
  35. pmc Corticotropin-releasing hormone receptor expression and functional signaling in murine gonadotrope-like cells
    Audrey F Seasholtz
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
    J Endocrinol 200:223-32. 2009
    ..Stimulation of the cells with CRHR2-specific ligands, urocortin 2 (UCN2) or urocortin 3 (UCN3), resulted in rapid increases in intracellular cAMP levels to 50-60% of the levels observed ..
  36. doi Neuroendocrine mechanisms in pregnancy and parturition
    Felice Petraglia
    University of Siena, Policlinico, Division of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics, and Reproductive Medicine, Viale Bracci, 53100 Siena, Italy
    Endocr Rev 31:783-816. 2010
    ..The CRH/Ucn family consists of four ligands: CRH, Ucn, Ucn2, and Ucn3. These peptides have a pleyotropic function and are expressed by human placenta and fetal membranes...
  37. doi Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats
    Shan Gao
    Department of Physiology, Diabetic Research Center, Chonbuk National University Medical School, Jeonju, Korea
    Am J Physiol Heart Circ Physiol 299:H1782-9. 2010
    b>Urotensin II (UII) is a vasoactive peptide with potent cardiovascular effects through a G protein-coupled receptor. Hypoxia stimulates the secretion of UII and atrial natriuretic peptide (ANP)...
  38. ncbi Cardiovascular role of urotensin II: effect of chronic infusion in the rat
    Andrew R Kompa
    NHMRC Centre of Clinical Research Excellence in Therapeutics, Departments of Medicine and Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Monash University, Alfred Hospital, Commercial Road, Prahran, VIC 3181, Australia
    Peptides 25:1783-8. 2004
    b>Urotensin II (UII) is a potent vaso-active peptide thought to have multiple roles in the regulation of cardiovascular physiology and pathophysiology...
  39. ncbi Liberation of urotensin II from the teleost urophysis: an historical overview
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 29:651-7. 2008
    During the past 20 years, urotensin II (UII) has progressed from being a peptide synthesized only in the urophysis of the caudal neurosecretory system of teleost fish to being considered an important physiological regulator in mammals ..
  40. doi Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse
    Hong Xia Wang
    Department of Pathophysiology, Capital Medical University, Beijing 100069, China
    Regul Pept 154:85-90. 2009
    b>Urotensin II (UII) is a somatostatin-like peptide recently identified to be involved in metabolic regulation and to play a significant role in diabetes and its complications...
  41. ncbi The signal transduction pathway in the proliferation of airway smooth muscle cells induced by urotensin II
    Ya Hong Chen
    Department of Respiratory Disease, Third Hospital, Peking University, Beijing 100083, China
    Chin Med J (Engl) 117:37-41. 2004
    Human urotensin II (UII) is the most potent mammalian vasoconstrictor identified so far. Our previous study showed that UII is a potent mitogen of airway smooth muscle cells (ASMC) inducing ASMC proliferation in a dose-dependent manner...
  42. ncbi A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker
    Ewa Rakowski
    Division of Cardiology, Suite L3 109, The Montreal General Hospital, McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
    J Mol Cell Cardiol 39:785-91. 2005
    Recent studies have postulated that the vasoactive peptide urotensin II (UII) plays a role in the control of vascular remodeling by inducing smooth muscle proliferation and fibroblast-mediated collagen deposition...
  43. doi Enhanced renal sensitivity of the spontaneously hypertensive rat to urotensin II
    Alaa E S Abdel-Razik
    Faculty of Life Sciences, University of Manchester, 1 124 Stopford Bldg, Oxford Road, Manchester M13 9PT, UK
    Am J Physiol Renal Physiol 295:F1239-47. 2008
    b>Urotensin II (UII) has been implicated widely in cardiovascular disease...
  44. doi Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype
    Nicolas Bousette
    Division of Cardiology and Department of Medicine, Montreal General Hospital, McGill University Health Center, Quebec, Canada
    Circ Res 105:686-95, 19 p following 695. 2009
    Expression of the vasoactive peptide Urotensin II (UII) is elevated in a number of cardiovascular diseases.
  45. ncbi Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension
    Diangang Liu
    Department of General Surgery, Xuan Wu Hospital, Capital Medical University, Beijing 100050, P R China
    Int J Mol Med 25:845-51. 2010
    b>Urotensin II (UII) and its receptor (UT or GPR14) are involved in liver fibrosis and portal hypertension. Nevertheless, expression of the UII/UT system in the liver of patients with portal hypertension has not been elucidated...
  46. ncbi Changes in the electrophysiological parameters of the posterior intestine of Anguilla anguilla (Pisces) induced by oxytocin, urotensin II and aldosterone
    B Baldisserotto
    Departamento de Fisiologia, Universidade Federal de Santa Maria, RS, Brasil
    Braz J Med Biol Res 30:35-9. 1997
    ..importance of the intestine in the osmoregulation of freshwater fishes, we determined the effects of oxytocin, urotensin II (UII), and aldosterone added to the serosal side of the isolated posterior intestine of the freshwater-adapted ..
  47. ncbi Determinants of corticotropin releasing factor. Receptor selectivity of corticotropin releasing factor related peptides
    Adam W Mazur
    Health Care Research Center, Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, Ohio 45040, USA
    J Med Chem 47:3450-4. 2004
    ..The recent discovery of the CRF2R selective peptide agonists, UCN2, UCN3 and URP, prompted investigations into the structural source of CRF1R versus CRF2R selectivity of CRF peptide ..
  48. ncbi Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes
    Helene Castel
    INSERM, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, University of Rouen, Mont Saint Aignan, France
    J Neurochem 99:582-95. 2006
    The urotensin II (UII) gene is primarily expressed in the central nervous system, but the functions of UII in the brain remain elusive. Here, we show that cultured rat astrocytes constitutively express the UII receptor (UT)...
  49. ncbi Fusion of diphtheria toxin and urotensin II produces a neurotoxin selective for cholinergic neurons in the rat mesopontine tegmentum
    S D Clark
    Laboratory of Molecular Neurobiology, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Neurochem 102:112-20. 2007
    b>Urotensin II is a neuropeptide first isolated from fish and later found in mammals: where it has potent cardiovascular, endocrine and behavioral effects...
  50. doi Effect of GABA A receptor activation on UT-coupled signaling pathways in rat cortical astrocytes
    Laurence Desrues
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, 76821 Mont Saint Aignan, France
    Peptides 29:727-34. 2008
    Cultured rat cortical astrocytes express two types of urotensin II (UII) binding sites: a high affinity site corresponding to the UT (GPR14) receptor and a low affinity site that has not been fully characterized...
  51. doi Neonatal immune challenge affects the regulation of estrus cyclicity and feeding behavior in female rats
    Takeshi Iwasa
    Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Int J Dev Neurosci 27:111-4. 2009
    ..In Experiment 2, the mRNA expression levels of corticotropin-releasing hormone (CRH), urocortin (UCN), urocortin 2 (UCN2), CRH receptor type 1 (CRH-R1) and CRH receptor type 2 (CRH-R2) in the hypothalamus were measured using real-time ..
  52. doi Characterization of the insulinostatic effect of urotensin II: a study in the perfused rat pancreas
    Ramona A Silvestre
    Hospital Universitario Puerta de Hierro and Department of Physiology, Medical School, Universidad Autonoma de Madrid, San Martin de Porres 4, 28035 Madrid, Spain
    Regul Pept 153:37-42. 2009
    We have investigated the effect of urotensin II (UII) on insulin secretion at normal and high glucose concentrations as well as induced by secretagogues acting on the B cell via different mechanisms...
  53. doi Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway
    Jin Tao
    Department of Neurobiology, Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, Suzhou, PR China
    Cell Signal 21:1436-43. 2009
    ..Activation of CRFR2 by UCN2 inhibited P-currents in a concentration-dependent manner (IC(50) approximately 0.07 microM)...
  54. doi The human urocortin 2 gene is regulated by hypoxia: identification of a hypoxia-responsive element in the 3'-flanking region
    Katrin Bühler
    Department of Biomedicine, CardioBiology, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Biochem J 424:119-27. 2009
    b>Ucn2 (urocortin 2) has been shown to exert potent beneficial effects in the cardiovascular system, including inhibition of apoptosis, improvement of cardiomyocyte contractility and decrease of oxidative stress...
  55. doi The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation
    Marie Jarry
    EA4310, Inserm U982, DC2N, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, Astrocyte and Vascular Niche, European Institute for Peptide Research IFRMP 23, University of Rouen, Mont Saint Aignan, Normandy, France
    Biochem J 428:113-24. 2010
    UII (urotensin II) and its paralogue URP (UII-related peptide) are two vasoactive neuropeptides whose respective central actions are currently unknown...
  56. pmc Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor
    Kuntal Pal
    Laboratory of Structural Sciences, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 285:40351-61. 2010
    ..releasing factor (CRF)/urocortin (Ucn) peptide hormones include four structurally similar peptides, CRF, Ucn1, Ucn2, and Ucn3, that regulate stress responses, metabolism, and cardiovascular function by activating either of two ..
  57. pmc Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families
    Herve Tostivint
    Institut National de la Santé et de la Recherche Médicale Unité 413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, University of Rouen, 76821 Mont Saint Aignan, France
    Proc Natl Acad Sci U S A 103:2237-42. 2006
    Although urotensin II (UII) and somatostatin 1 (SS1) exhibit some structural similarities, their precursors do not show any appreciable sequence identity and, thus, it is widely accepted that the UII and SS1 genes do not derive from a ..
  58. ncbi Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner
    E Dermitzaki
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion GR 710 03, Crete, Greece
    Endocrinology 148:1524-38. 2007
    ..CRF, urocortin I (UCN1), urocortin II (UCN2), and CRF receptor type 1 (CRF1) and 2 (CRF2) were present in human and rat adrenal medulla as well as the PC12 ..
  59. doi Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction
    Christophe Dubessy
    Neuronal and Neuroendocrine Communication and Differentiation, EA4310, INSERM U413, European Institute for Peptide Research IFRMP 23, University of Rouen, Mont Saint Aignan, France
    J Neurochem 107:361-74. 2008
    b>Urotensin II (UII) and UII-related peptide (URP) are paralog neuropeptides whose existence and distribution in mouse have not yet been investigated...
  60. doi Differential regulation of urocortins1-3 mRNA in human umbilical vein endothelial cells
    Kazunori Kageyama
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu cho Hirosaki, Aomori 036 8562, Japan
    Regul Pept 155:131-8. 2009
    ..Human umbilical vein endothelial cells (HUVECs) express Ucn1, Ucn2, and Ucn3 mRNAs, but not CRF mRNA, and the receptor, CRF(2 alpha) receptor mRNA...
  61. pmc Urocortin induced expression of COX-2 and ICAM-1 via corticotrophin-releasing factor type 2 receptor in rat aortic endothelial cells
    Rongjian Zhang
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Br J Pharmacol 158:819-29. 2009
    ..In the present study, the effects of Ucn1 on COX-2 and ICAM-1 expression in lipopolysaccharide (LPS)-induced rat aortic endothelial cells (RAECs) were investigated and the mechanisms involved explored...
  62. doi Novel and potent small-molecule urotensin II receptor agonists
    Fredrik Lehmann
    Department of Chemistry, Medicinal Chemistry, University of Gothenburg, Goteborg, Sweden
    Bioorg Med Chem 17:4657-65. 2009
    A series of analogs of the non-peptidic urotensin II receptor agonist N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]-4-phenylbenzamide (FL104) has been synthesized and evaluated pharmacologically...
  63. doi Urotensin II protects ischemic reperfusion injury of hearts through ROS and antioxidant pathway
    Shan Gao
    Department of Physiology, Research Center for Endocrine Sciences, Chonbuk National University Medical School, Jeonju, Republic of Korea
    Peptides 36:199-205. 2012
    b>Urotensin II (UII) is a vasoactive peptide which is bound to a G protein-coupled receptor...
  64. doi Urotensin II and the kidney
    Robyn G Langham
    University of Melbourne, Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Curr Opin Nephrol Hypertens 22:107-12. 2013
    b>Urotensin II (UTS2), the most potent vasoconstrictor identified thus far, is an undecapeptide hormone with a structure that is highly conserved through mammalian phylogeny...
  65. doi Regulation of corticotropin-releasing factor and urocortin 2/3 mRNA by leptin in hypothalamic N39 cells
    Satoshi Yamagata
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Peptides 50:1-7. 2013
    ..The study identified mRNA expression of the leptin receptor (Ob-R) and its subtypes, CRF, and Ucn2/3 in mouse hypothalamic N39 cells...
  66. doi Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor
    Xavier Sainsily
    Department of Pharmacology, Institut de Pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H5N4
    Biochem Pharmacol 92:280-8. 2014
    The vasoactive urotensin-II (UII), a cyclic undecapeptide widely distributed in cardiovascular, renal and endocrine systems, specifically binds the UII receptor (UT receptor), a G protein-coupled receptor (GPCR)...
  67. ncbi Structure-activity relationships of human urotensin II and related analogues on rat aortic ring contraction
    Patricia Labarrère
    Centre de Biochimie Structurale, CNRS UMR 5048, INSERM UMR 554, Universite de Montpellier 1, 34090 Montpellier, France
    J Enzyme Inhib Med Chem 18:77-88. 2003
    The sequence of human urotensin II (UII) has been recently established as H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH, and it has been reported that UII is the most potent mammalian vasoconstrictor peptide identified so far...
  68. ncbi Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions
    Luise Pernar
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:1305-11. 2004
    ..Relatively low doses of urocortin II (UII) (0...
  69. ncbi Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists
    Antonio Lavecchia
    Dipartimento di Chimica Farmaceutica e Tossicologica, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Med Chem 48:2480-92. 2005
    The human urotensin II receptor (h-UTR) is a member of the family of rhodopsin-like G-protein-coupled receptors (GPCRs) involved in the modulation of the functionality of many tissues and organs...
  70. ncbi Inhibitory effects of glucocorticoids on urocortin-mediated increases in interleukin-6 gene expression in rat aortic smooth muscle cells
    Kazunori Kageyama
    Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University School of Medicine, 5 Hirosaki, Aomori 036 8562, Japan
    Peptides 28:1059-67. 2007
    Urocortin (Ucn) 1, Ucn2, and Ucn3 have potent effects on appetite and the cardiovascular system. Endogenous Ucns in combination with CRF receptor type 2beta may have a physiological role in the cardiovascular system...
  71. ncbi Urotensin II induces migration of endothelial progenitor cells via activation of the RhoA/Rho kinase pathway
    Shengkai Xu
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P R China
    Tohoku J Exp Med 219:283-8. 2009
    b>Urotensin II (UII) is a vasoactive peptide with many potent effects in the cardiorenovascular system and may be involved in the pathogenesis of atherosclerosis...
  72. pmc Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon
    Sumei Liu
    Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH, USA
    Br J Pharmacol 159:222-36. 2010
    ..Nevertheless, details of the neural mechanism of action for Ucns have been unclear. We have, here, tested the hypothesis that Ucns act in the enteric nervous system (ENS) to influence colonic motor behaviour...
  73. doi Occurrence of two distinct urotensin II-related peptides in zebrafish provides new insight into the evolutionary history of the urotensin II gene family
    Caroline Parmentier
    Unité Mixte de Recherche 7221, Centre National de la Recherche Scientifique Muséum National d Histoire Naturelle, Evolution des Regulations Endocriniennes, MNHN, 7 rue Cuvier, 75231 Paris Cedex 05, France
    Endocrinology 152:2330-41. 2011
    The urotensin II (UII) family is currently known to consist of two paralogous peptides, namely UII and UII-related peptide (URP)...
  74. doi Development of filtration-based time-resolved fluorescence assay for the high-throughput screening of urotensin II receptor antagonist
    Kwang Seok Oh
    Bio organic Science Division, Korea Research Institute of Chemical Technology Yuseong, Daejeon, Republic of Korea
    Assay Drug Dev Technol 9:514-21. 2011
    ..For this assay development, the human recombinant urotensin II (UII) was modified by labeling europium at its N-terminal position (Eu-UII) and used as a fluorescent tracer...
  75. doi Effects of urotensin II on functional activity of late endothelial progenitor cells
    Kaihong Yi
    Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China
    Peptides 33:87-91. 2012
    b>Urotensin II (UII) is a potent vasoactive cyclic peptide which has multiple effects on the cardiovascular system. However, the effects of UII on late endothelial progenitor cells (EPCs) are still unclear...
  76. doi Characterization of the true ortholog of the urotensin II-related peptide (URP) gene in teleosts
    Feng B Quan
    UMR 7221 CNRS MNHN Evolution des Régulations Endocriniennes, Museum national d histoire naturelle, 75231 Paris, France
    Gen Comp Endocrinol 177:205-12. 2012
    It has been recently established that the urotensin II (UII) family consists of four distinct paralogs in bony vertebrates, namely UII, and the three UII-related peptides (URPs) called URP, URP1 and URP2...
  77. doi Urotensin II promotes the production of LTC4 in rat aortic adventitial fibroblasts through NF-κB-5-LO pathway by p38 MAPK and ERK activations
    Xiao Dong
    Division of Cardiology, Department of Internal Medicine, Peking University First Hospital, Xishikudajie 8, West District, Beijing, 10034, People s Republic of China
    Heart Vessels 28:514-23. 2013
    Adventitia is the outer part of the arterial wall where the inflammatory response often occurs. Urotensin II (UII) is a potent vasoconstrictive peptide that also promotes the inflammatory process in patients with cardiovascular disease...
  78. doi Stress-induced changes in gene expression of urocortin 2 and other CRH peptides in rat adrenal medulla: involvement of glucocorticoids
    Andrej Tillinger
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, USA
    J Neurochem 125:185-92. 2013
    ..Urocortin 2 (Ucn2) has the highest basal gene expression and is increased by > 30-fold in response to single IMO and about 10-..
  79. pmc Desensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment
    Richard L Hauger
    Center of Excellence for Stress and Mental Health, San Diego VA Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA Department of Psychiatry, School of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA Electronic address
    Regul Pept 186:62-76. 2013
    ..Exposure of human retinoblastoma Y79 cells to selective (UCN2, UCN3 or stresscopins) and non-selective (UCN1 or sauvagine) agonists prominently desensitized CRF2(a) receptors in ..
  80. doi Endothelial nitric oxide synthase (eNOS) (Glu298Asp) and urotensin II (UTS2 S89N) gene polymorphisms in preeclampsia: prediction and correlation with severity in Egyptian females
    Walid S El-Sherbiny
    Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt
    Hypertens Pregnancy 32:292-303. 2013
    ..Early prediction of preeclampsia can minimize maternal and fetal complications. Gene polymorphisms are promising markers for early prediction of preeclampsia...
  81. doi Estrogens downregulate urocortin 2 expression in rat uterus
    Kenichiro Watanabe
    Departments of Obstetrics and Gynecology Physiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Endocrinol 219:269-78. 2013
    Urocortin 2 (Ucn2) is a member of the corticotropin-releasing factor peptide family and is expressed by various tissues, including reproductive tissues such as the uterus, ovary, and placenta...
  82. pmc The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat
    Ellen J Forty
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS ONE 8:e83317. 2013
    b>Urotensin II (UII) concentrations are raised both in humans with hypertension and in spontaneously hypertensive rats (SHR)...
  83. pmc Urotensin-II system in genetic control of blood pressure and renal function
    Radoslaw Debiec
    Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
    PLoS ONE 8:e83137. 2013
    ..The signatures of evolutionary forces acting on urotensin-II system indicate that it may have evolved towards loss of function since the divergence of primates. ..
  84. doi Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma
    C Lecointre
    Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, DC2N, Astrocyte and Vascular Niche, Biomedical Research Institute IRIB, TC2N network, University of Rouen, Mont Saint Aignan, France
    Oncogene 34:5080-94. 2015
    ..Here we establish that glioma express the vasoactive peptide urotensin II (UII) and its receptor UT and that UT-mediated signaling cascades are involved in glioma cell migration and ..
  85. doi TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children
    T Priego
    Laboratory of Molecular Biology, Nutrition and Biotechnology Nutrigenomics T P, J S, C P, A P, University of the Balearic Islands and Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, CIBEROBN, Palma de Mallorca 07122, Spain Leibniz Institute for Prevention Research and Epidemiology BIPS W A, Bremen D 28359, Germany Institute of Statistics, Faculty of Mathematics and Computer Science W A, Bremen University, Bremen 28359, Germany Department of Public Health Department of Movement and Sport Sciences S D H, Faculty of Medicine and Health Sciences, Ghent University, Ghent 9000, Belgium Research and Education of Child Health Institute Y K, Strovolos 2015, Cyprus Department of Public Health and Community Medicine L L, University of Gothenburg, Göthenburg 405 30, Sweden Department of Pediatrics D M, University of Pecs, Pécs 7622, Hungary Growth, Exercise, Nutrition and Development Research group L A M, Facultad de Ciencias de la Salud, University of Zaragoza, Zaragoza 50018, Spain Unit of Epidemiology and Population Genetics P R, A s, Institute of Food Sciences
    J Clin Endocrinol Metab 100:3556-64. 2015
    ..Peripheral blood cells (PBCs) represent a promising new tool for identifying novel, transcript-based biomarkers...
  86. pmc IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure
    Liang Ming Liu
    Department of Hepatology, Songjiang Hospital Affiliated to The First People s Hospital Shanghai Jiaotong University, Shanghai, China
    Oncotarget 7:49027-49041. 2016
    The urotensin II/urotensin receptor (UII/UT) system can mediate inflammatory liver injury in acute liver failure (ALF); however; the related mechanism is not clear...
  87. ncbi The caudal neurosecretory system and its afferent synapses in the goldfish, Carassius auratus: morphology, immunohistochemistry, and fine structure
    C Cioni
    Department of Animal and Human Biology, La Sapienza University, Rome, Italy
    J Morphol 235:59-76. 1998
    ..neurosecretory system were investigated by means of immunohistochemical localization of urotensins I and II (UI and UII) and electron microscopic examination of the caudal neurosecretory neurons, the urophysis, and the synaptic ..
  88. ncbi Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14)
    M Mori
    Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, 300 4293, Japan
    Biochem Biophys Res Commun 265:123-9. 1999
    Two molecular species of urotensin II (UII) were isolated from porcine spinal cords and identified as the endogenous ligands of a G-protein-coupled orphan receptor, SENR (sensory epithelium neuropeptide-like receptor), which is identical ..
  89. ncbi Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas
    Ramona A Silvestre
    Hospital Universitario Puerta de Hierro and Department of Physiology, Universidad Autonoma de Madrid, Madrid, Spain
    Eur J Endocrinol 151:803-9. 2004
    Previous work from our laboratory has demonstrated that frog urotensin-II (UII), at a high concentration, inhibits glucose-induced insulin release in the rat pancreas...
  90. ncbi Urocortin 2 suppresses host resistance to Listeria monocytogenes infection via up-regulation of interleukin-10
    Hiroshi Sashinami
    Department of Bacteriology, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, Aomori 036 8562, Japan
    Endocrinology 146:5003-11. 2005
    ..When mice were administered ip with CRF, urocortin (Ucn), or Ucn2 30 min prior a sublethal infection with L...
  91. ncbi From heart to mind. The urotensin II system and its evolving neurophysiological role
    Hans Peter Nothacker
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    FEBS J 272:5694-702. 2005
    ..b>Urotensin II (UII), a peptide originally isolated from fish and known for its strong cardiovascular effects in mammals, is ..
  92. ncbi Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes
    Alberto Imperatore
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetrics and Gynecology, University of Siena, Siena, Italy
    Am J Obstet Gynecol 195:288-95. 2006
    Urocortin 2 (UCN2) and urocortin 3 (UCN 3) are recently identified neuropeptides showing homology to corticotropin-releasing factor (CRF)...
  93. ncbi Urotensin-II and UII-receptor expression and function in the rat adrenal cortex
    Giovanna Albertin
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, Italy
    Int J Mol Med 17:1111-5. 2006
    Urotensin-II (UII) is a potent hypertensive peptide, which has been recognized as an endogenous ligand of the G protein-coupled receptor (GPR)-14, now named UT-R...
  94. ncbi Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation
    Nicolas Bousette
    Division of Cardiology, Montreal General Hospital, McGill University Health Center, Quebec, Canada
    J Mol Cell Cardiol 41:285-95. 2006
    Expression of urotensin II (UII) is significantly elevated in the hearts of patients with congestive heart failure (CHF)...
  95. ncbi Design, parallel synthesis and SAR of novel urotensin II receptor agonists
    Fredrik Lehmann
    Department of Chemistry, Medicinal Chemistry, Goteborg University, Kemivagen 10, SE 412 96 Goteborg, Sweden
    Eur J Med Chem 42:276-85. 2007
    A 30-membered library of amides based on the potent urotensin II (UII) receptor agonist FL104, has been synthesized from ten different carboxylic acids and three amines...
  96. ncbi Urotensin II inhibits carotid sinus baroreflex in anesthetized male rats
    Yu Ming Wu
    Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China
    Acta Pharmacol Sin 28:216-20. 2007
    To study the effects of urotensin II (UII) on the carotid sinus baroreflex (CSB).
  97. ncbi [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes
    Mickael Diallo
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, Mont Saint Aignan, France
    Peptides 29:813-9. 2008
    Cultured rat astrocytes, which express functional urotensin II (UII)/UII-related peptide (URP) receptors (UT), represent a very suitable model to investigate the pharmacological profile of UII and URP analogs towards native UT...
  98. doi Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5
    Maria M Malagon
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14014 Cordoba, Spain
    Peptides 29:711-20. 2008
    The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR)...
  99. doi Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure
    Takashi Nakayama
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Aoba ku, Sendai 980 8578, Japan
    Peptides 29:801-8. 2008
    b>Urotensin II-related peptide (URP) is a novel endogenous ligand for urotensin II receptor (UT-R)...
  100. doi Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat
    Yonggang Zhang
    Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
    Regul Pept 151:88-94. 2008
    b>Urotensin II (UII) is a potent vasoconstrictive peptide; however, its significance in vascular adventitia has not been clearly elucidated...
  101. doi Targeted overexpression of the human urotensin receptor transgene in smooth muscle cells: effect of UT antagonism in ApoE knockout mice fed with Western diet
    Panayiota Papadopoulos
    Division of Cardiology, Montreal General Hospital, McGill University Health Center, Montreal, Que, Canada
    Atherosclerosis 204:395-404. 2009
    b>Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis. However, their exact role in atherosclerosis remains to be determined...

Research Grants13

  1. CRF System and Methamphetamine Extinction
    Andrey E Ryabinin; Fiscal Year: 2010
    ..of two main types of receptors, CRF1 and CRF2, and four endogenous ligands, CRF, urocortin 1 (Ucn1), urocortin 2 (Ucn2) and urocortin 3 (Ucn3)...
  2. Modulation of Dopaminergic VTA Neurons by Urotensin II
    STEWART DONALDSON CLARK; Fiscal Year: 2010
    ..The candidate has shown that the mesopontine-VTA-NAc pathway is modulated by the novel neuropeptide urotensin II (UII). The candidate has also shown utility of a fusion of diphtheria toxin with Ull...
  3. Novel Urotensin II Antagonists
    AJAY REGE; Fiscal Year: 2005
    ..Consequently, the UII-UTR signaling pathway has been implicated in different cardiovascular pathologies, such as pulmonary arterial ..
  4. Universal Influenza A Vaccine
    Ashley Birkett; Fiscal Year: 2004
    ..formulations, designing human clinical studies, and establishing correlates of protection for use in human Phase UII studies...
  5. The hypocretins and alcohol dependence
    Luis de Lecea; Fiscal Year: 2003
    ..The development of these mouse models will generate invaluable tools to assess the role of the hypocretins on drug abuse, and may help to design better treatments for sleep disorders associated with alcoholism. ..
  6. NEUROPEPTIDE CORTISTATIN AND SLEEP
    Luis de Lecea; Fiscal Year: 2006
    ..abstract_text> ..
  7. Hypocretin and Drug Addiction
    Luis de Lecea; Fiscal Year: 2010
    ..This demonstration may lead to future treatments to prevent relapse. ..
  8. NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIA
    Andrey Ryabinin; Fiscal Year: 2001
    ..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
  9. Perioculomotor area and alcohol
    Andrey E Ryabinin; Fiscal Year: 2010
    ..These studies will provide novel important information indicating how these recently identified neurons robustly regulate alcohol intake. ..
  10. ROLE OF UROCORTIN IN MAMMALIAN BRAIN AND PITUITARY
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ....
  11. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ....
  12. Identification of a novel bioactive peptide
    Hans Peter Nothacker; Fiscal Year: 2004
    ..The BRS-3 ligands will prove as an invaluable tool to answer the functional significance and understand the physiological role of the BRS-3 system in the regulation of energy balance. ..
  13. High-Throughput Assay for G-Protein Coupled Receptors in Pain Research
    Olivier Civelli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..