USP11

Summary

Gene Symbol: USP11
Description: ubiquitin specific peptidase 11
Alias: UHX1, ubiquitin carboxyl-terminal hydrolase 11, deubiquitinating enzyme 11, ubiquitin carboxyl-terminal hydrolase, X-linked, ubiquitin thioesterase 11, ubiquitin thiolesterase 11, ubiquitin-specific processing protease 11
Species: human

Top Publications

  1. pmc USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer
    Soley Bayraktar
    Departmentsof Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer J 19:10-7. 2013
  2. pmc USP11 augments TGFβ signalling by deubiquitylating ALK5
    Mazin A Al-Salihi
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, UK
    Open Biol 2:120063. 2012
  3. pmc Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM
    Haruko Ideguchi
    First Department of Internal Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Japan
    Biochem J 367:87-95. 2002
  4. doi USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor
    Long Zhang
    Department of Molecular Cell Biology, Leiden University Medical Center, Postbus 9600 2300 RC Leiden, The Netherlands
    Nat Cell Biol 14:717-26. 2012
  5. pmc BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
    Alan R Schoenfeld
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1130, New York, NY 10029, USA
    Mol Cell Biol 24:7444-55. 2004
  6. ncbi The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)
    Tomoko Yamaguchi
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo, Japan
    J Biol Chem 282:33943-8. 2007
  7. pmc USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity
    Ching Hui Lin
    National Health Research Institutes, 35 Keyan Rd, Zhunan Town, Miaoli County 350, Taiwan
    J Biol Chem 283:15681-8. 2008
  8. pmc USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha
    Wenjing Sun
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States
    Cell Signal 22:386-94. 2010
  9. pmc Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
    Goedele N Maertens
    Cancer Research UK, London Research Institute, London, UK
    EMBO J 29:2553-65. 2010
  10. pmc Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication
    Tsai Ling Liao
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    EMBO J 29:3879-90. 2010

Scientific Experts

  • Jing Zhao
  • Renhua Huang
  • Caitlyn Vlasschaert
  • Dawn L Thiselton
  • Stephen Harper
  • Zhuan Zhou
  • Eun Woo Lee
  • Encheng Zhang
  • Zhiwei Xu
  • Ning Li
  • Key Hwan Lim
  • Miao Yu
  • A M Jacko
  • Fang Zhang
  • E W Lee
  • Alexandre Orthwein
  • Ivo A Hendriks
  • Jia Ying Ke
  • Hsin Chieh Wu
  • Qisheng Li
  • Joana Marquez
  • Richard A Burkhart
  • Soley Bayraktar
  • Ingrid Dreveny
  • David J Scott
  • Jonas Emsley
  • Hongsup Kim
  • Honghui Ma
  • Mazin A Al-Salihi
  • Long Zhang
  • Paul R Elliott
  • Alex C Faesen
  • Tsai Ling Liao
  • Timothy D Wiltshire
  • Wenjing Sun
  • Goedele N Maertens
  • Ching Hui Lin
  • Tomoko Yamaguchi
  • Alan R Schoenfeld
  • Li Zhen Chen
  • Yi Fan Lian
  • Jianping Chen
  • Ivet Bahar
  • D J Kass
  • Xue Kang Qi
  • Aiping Luo
  • Yu Fan
  • Hao Jiong Zhang
  • Yi Xin Zeng
  • Jiansheng Shi
  • Mingyue Tan
  • Bing Shen
  • Gui Ping He
  • J Tan
  • Jaewhan Song
  • Ling Gao
  • Xiaohong Li
  • Hui Qiong Han
  • Bo Hua Kuang
  • You Yuan Yao
  • Dajun Yang
  • Indira Shrivastava
  • Jung Hyun Park
  • Jing Yuan
  • Kwang Hyun Baek
  • Yong Wan
  • L Nan
  • Bing Chun Zhao
  • Wenhui Zhao
  • Yu chen Zhang
  • Kun Liu
  • Yuhong Ji
  • Pingzhao Zhang
  • Cheng Cheng Deng
  • Miao Xu
  • Yi Huang
  • Yifen Shen
  • Jun Wang
  • Mingjing He
  • Xingyu Mu
  • Jiantao Xiao
  • Suresh Ramakrishna
  • Zhihua Liu
  • Lin Feng
  • Lu Yang
  • Qi Sheng Feng
  • Bharathi Suresh
  • Young Soo Kim
  • Yan Qin
  • Lijian Han

Detail Information

Publications42

  1. pmc USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer
    Soley Bayraktar
    Departmentsof Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer J 19:10-7. 2013
    ..We sought to examine the predictive and prognostic relevance of USP-11 in patients treated with neoadjuvant systemic therapy (NST) for breast cancer...
  2. pmc USP11 augments TGFβ signalling by deubiquitylating ALK5
    Mazin A Al-Salihi
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, UK
    Open Biol 2:120063. 2012
    ..In this report, we identify a deubiquitylating enzyme USP11 as an interactor of SMAD7. USP11 enhances TGFβ signalling and can override the negative effects of SMAD7...
  3. pmc Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM
    Haruko Ideguchi
    First Department of Internal Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Japan
    Biochem J 367:87-95. 2002
    ..proteins by using a yeast two-hybrid method and isolated a cDNA encoding the ubiquitin-specific protease USP11. The full-length cDNA of USP11 was cloned from a Jurkat cell library...
  4. doi USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor
    Long Zhang
    Department of Molecular Cell Biology, Leiden University Medical Center, Postbus 9600 2300 RC Leiden, The Netherlands
    Nat Cell Biol 14:717-26. 2012
    ..Moreover, AKT-induced breast cancer cell migration was inhibited by USP4 depletion and TβRI kinase inhibition. Our results uncover USP4 as an important determinant for crosstalk between TGF-β and AKT signalling pathways...
  5. pmc BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
    Alan R Schoenfeld
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1130, New York, NY 10029, USA
    Mol Cell Biol 24:7444-55. 2004
    ..to identify novel proteins that associate with the BRCA2 gene product, we found that a deubiquitinating enzyme, USP11, formed specific complexes with BRCA2...
  6. ncbi The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)
    Tomoko Yamaguchi
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo, Japan
    J Biol Chem 282:33943-8. 2007
    ..The present studies show that a deubiquitinating enzyme, USP11, specifically regulates IkappaB kinase alpha (IKKalpha) among the NF-kappaB signaling molecules...
  7. pmc USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity
    Ching Hui Lin
    National Health Research Institutes, 35 Keyan Rd, Zhunan Town, Miaoli County 350, Taiwan
    J Biol Chem 283:15681-8. 2008
    ..Using the yeast two-hybrid system, we found that USP11 (ubiquitin-specific protease 11), a member of a protein family that cleaves polyubiquitin chains and/or ubiquitin ..
  8. pmc USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha
    Wenjing Sun
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States
    Cell Signal 22:386-94. 2010
    ..Using a proteomic approach, we have identified Ubiquitin Specific Peptidase 11 (USP11) as an IkappaBalpha associated deubiquitinase. Overexpression of USP11 inhibits IkappaBalpha ubiquitination...
  9. pmc Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
    Goedele N Maertens
    Cancer Research UK, London Research Institute, London, UK
    EMBO J 29:2553-65. 2010
    ..Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-purify with human PRC1-type complexes through direct interactions with the Psc orthologues MEL18 and BMI1, and ..
  10. pmc Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication
    Tsai Ling Liao
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    EMBO J 29:3879-90. 2010
    ..We observed that downregulation of a cellular deubiquitinating enzyme USP11 resulted in enhanced virus production, suggesting that USP11 could inhibit influenza virus replication...
  11. doi The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Alex C Faesen
    Division of Biochemistry and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Chem Biol 18:1550-61. 2011
    ..USPs can hydrolyze all linkages and show modest Ub-chain preferences, although some show a lack of activity toward linear di-Ub. This comprehensive kinetic analysis highlights the variability within the USP family...
  12. doi Structural variability of the ubiquitin specific protease DUSP-UBL double domains
    Paul R Elliott
    The University of Liverpool, Institute of Integrative Biology, Biosciences Building, Crown Street, Liverpool L69 7ZB, United Kingdom
    FEBS Lett 585:3385-90. 2011
    ..We identified structural features that dictate different dispositions between constituent domains, which in turn may influence respective binding properties...
  13. pmc USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics
    E W Lee
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Cell Death Differ 22:1463-76. 2015
    ..Ubiquitin-specific protease 11 (USP11) is a deubiquitylase that directly stabilizes cIAP2...
  14. pmc Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein
    Encheng Zhang
    Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai JiaoTong University Shanghai, P R China
    Am J Cancer Res 6:2901-2909. 2016
    ..In this study, we identify deubiquitinating enzyme USP11 as a novel VGLL4 interactor...
  15. doi USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage
    Zhiwei Xu
    Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, 226001, Jiangsu Province, China
    J Mol Neurosci 58:16-27. 2016
    ..b>USP11, located on the X chromosome, 6 is a member of USP subclass of the DUB family...
  16. pmc Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step
    Renhua Huang
    Department of Biological Sciences, University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL 60607, USA
    Int J Mol Sci 16:23587-603. 2015
    ..kinase kinase 5 (MAP2K5), Splicing factor 3A subunit 1 (SF3A1) and ubiquitin carboxyl-terminal hydrolase 11 (USP11). The affinities of the resulting monobodies are typically in the single-digit nanomolar range...
  17. pmc Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11
    Caitlyn Vlasschaert
    Department of Biology, University of Ottawa, Ottawa, Canada
    BMC Evol Biol 15:230. 2015
    USP4, USP15 and USP11 are paralogous deubiquitinating enzymes as evidenced by structural organization and sequence similarity...
  18. pmc USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168
    Miao Yu
    From the Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function and
    J Biol Chem 291:959-67. 2016
    ..Here, we found that RNF8/RNF168 ubiquitylates γH2AX. We identified that USP11 is a unique deubiquitylation enzyme for γH2AX...
  19. pmc A mechanism for the suppression of homologous recombination in G1 cells
    Alexandre Orthwein
    The Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nature 528:422-6. 2015
    ..6). PALB2 ubiquitylation suppresses its interaction with BRCA1 and is counteracted by the deubiquitylase USP11, which is itself under cell cycle control...
  20. pmc Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth
    Key Hwan Lim
    Department of Biomedical Science, CHA University, Gyeonggi do 463 400, Republic of Korea
    Oncotarget 7:14441-57. 2016
    ..Here, we analyzed the ability of ubiquitin-specific protease 11 (USP11) as a novel regulator of Mgl-1 and it requires RanBPM to regulate proteasomal degradation of Mgl-1...
  21. pmc USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
    Eun Woo Lee
    Department of Biochemistry College of Life Science and Biotechnology Yonsei University Seoul, Korea
    Mol Cell Oncol 3:e1029829. 2016
    ..We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.
  22. doi A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis
    Ning Li
    Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat sen University Cancer Center, Guangzhou 510060, China
    Cancer Lett 381:14-22. 2016
    ..The in vitro antitumor effect was RIPK1-dependent, whereas it was independent on IAPs, USP11, or EBV...
  23. pmc Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury
    Jing Zhao
    Department of Medicine, University of Pittsburgh, School of Medicine, Acute Lung Injury Center of Excellence, Vascular Medical Institute, United States Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, United States Electronic address
    EBioMedicine 10:195-203. 2016
    ..The stability of LPA1 is up-regulated by ubiquitin-specific protease 11 (USP11), which deubiquitinates LPA1 and enhances LPA1-mediated pro-inflammatory effects...
  24. pmc Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis
    Zhuan Zhou
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, United States
    EBioMedicine . 2016
    ..This led to the identification of USP11 as a critical determinant of mammary tumor initiation and progression...
  25. pmc De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II
    A M Jacko
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Death Dis 7:e2474. 2016
    ..Here we reveal that a de-ubiquitinating enzyme, USP11, promotes TGFβ-1 signaling through de-ubiquitination and stabilization of TβRII...
  26. pmc Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains
    Stephen Harper
    Centre for Biomolecular Sciences, University of Nottingham, University Park Campus, Nottingham, NG7 2RD, United Kingdom
    Biochemistry 53:2966-78. 2014
    The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and TGFβ signaling. We report the first characterization of the USP11 domain architecture and its role in regulating the enzymatic activity...
  27. pmc Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle
    Qisheng Li
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 10:e1004163. 2014
    ..enzyme UBE2J1, and 39 other host factors are required for HCV RNA replication, while the deubiquitinating enzyme USP11 and multiple other cellular genes are specifically involved in HCV IRES-mediated translation...
  28. pmc USP11 regulates p53 stability by deubiquitinating p53
    Jia Ying Ke
    College of Chemistry and Life Science, Quanzhou Normal University, Quanzhou 36200, China The Higher Educational Key Laboratory for Molecular Biology and Pharmacology of Fujian Province, Quanzhou 36200, China Xiamen Women and Children Health Hospital, Xiamen 361005, China Shouguang People s Hospital, Shouguang 262700, China Department of Orthopedics, Central Hospital of Zibo, Zibo 255000, China Department of Pathology, University of Chicago, Chicago 60102, Illinois, USA Department of Pathology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 36200, China
    J Zhejiang Univ Sci B 15:1032-8. 2014
    ..To better understand the regulation of p53, we tested the interaction between p53 and USP11 using co-immunoprecipitation...
  29. pmc Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4)
    Ivo A Hendriks
    From the Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands and
    J Biol Chem 290:15526-37. 2015
    ..Using a proteomic approach, we identified the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-component, as a functional interactor of RNF4...
  30. doi USP11 regulates PML stability to control Notch-induced malignancy in brain tumours
    Hsin Chieh Wu
    1 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan 2 Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    Nat Commun 5:3214. 2014
    ..Here we identify USP11 as a PML regulator by RNAi screening...
  31. doi Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival
    Richard A Burkhart
    Thomas Jefferson University, 1015 Walnut Street, Curtis 611A, Philadelphia, PA 19107, USA
    Mol Cancer Res 11:901-11. 2013
    ..Ubiquitin-specific peptidase 11 (USP11), an enzyme that interacts with the DDR protein BRCA2, was recently discovered to play a key role in DNA double-..
  32. doi Identification of hepatic microvascular adhesion-related genes of human colon cancer cells using random homozygous gene perturbation
    Joana Marquez
    Department of Cellular Biology and Histology, Basque Country University School of Medicine and Dentistry, Leioa, Bizkaia, Spain
    Int J Cancer 133:2113-22. 2013
    ..DGCR8 and EFEMP1 genes) and their silenced status in nonadherent HT-29 cells (DGKE, DPY19L1, KIAA0753, PVR and USP11 genes)...
  33. pmc M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability
    Honghui Ma
    Laboratory of Epigenetics, Institute of Biomedical Sciences, and Department of Biochemistry, Fudan University Medical School, 138 YiXue Yuan Road, Shanghai 200032, China
    Proc Natl Acad Sci U S A 109:4828-33. 2012
    ..These findings identify a molecular mechanism by which cellular UHRF1 level is regulated, which may impact cell proliferation...
  34. pmc Regulation of universal stress protein genes by quorum sensing and RpoS in Burkholderia glumae
    Hongsup Kim
    Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    J Bacteriol 194:982-92. 2012
    ..glumae. In the whole genome of B. glumae BGR1, 11 usp genes (usp1 to usp11) were identified...
  35. ncbi A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders
    D A Swanson
    Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 5:533-8. 1996
    ..Additionally, there is evidence that members of the ubiquitin hydrolase family may play a role in oncogenesis and a locus implicated in ovarian cancer is also located within this region...
  36. ncbi UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2
    O Brandau
    Abteilung für Medizinische Genetik, Kinderpoliklinik der Universität, Munchen, Germany
    Eur J Hum Genet 6:459-66. 1998
    The gene for ubiquitin hydrolase on the X chromosome (UHX1), cloned and mapped to Xp21.2-p11.2, is a candidate gene for retinal diseases...
  37. ncbi Deubiquitinating enzymes: a new class of biological regulators
    A D'ANDREA
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Crit Rev Biochem Mol Biol 33:337-52. 1998
    ..Here we explore the structural and biochemical properties of deubiquitinating enzymes and their emerging roles as cellular switches...
  38. ncbi Physical map covering a 2 Mb region in human xp11.3 distal to DX6849
    K L Stoddart
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Gene 227:111-6. 1999
    ..The contig is merged with published physical maps both in the distal and in the centromeric direction of Xp, and provides reagents to aid in the DNA sequencing and the finding of genes in this region of the human genome...
  39. ncbi An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders
    Dawn L Thiselton
    Department of Molecular Genetics, Institute of Ophthalmology, University College, London, EC1V 9EL, UK
    Genomics 79:560-72. 2002
    ..positioning 10 polymorphic microsatellites (one of which is novel), 16 ESTs, and 12 known genes (RP2, PCTK1, UHX1, UBE1, RBM10, ZNF157, SYN1, ARAF1, TIMP1, PFC, ELK1, UXT)...
  40. ncbi Isolation and characterization of the mouse ubiquitin-specific protease Usp15
    Corinne Angelats
    Division of Molecular Medicine, John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT 2601, Australia
    Mamm Genome 14:31-46. 2003
    ..Phylogenetic studies suggest that a sequence currently identified as a chicken Usp4 ortholog is in fact a USP15 ortholog, while bona-fide chicken, cow, and rat Usp4 orthologs can be identified in EST databases...
  41. pmc Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair
    Timothy D Wiltshire
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 285:14565-71. 2010
    ..This screen identified the deubiquitylating enzyme USP11 as a participant in HR repair of DNA double-strand breaks...
  42. doi Structure of the USP15 N-terminal domains: a β-hairpin mediates close association between the DUSP and UBL domains
    Stephen Harper
    Centre for Biomolecular Sciences, University of Nottingham, University Park Campus, Nottingham, NG7 2RD, United Kingdom
    Biochemistry 50:7995-8004. 2011
    ..USP15 forms a subfamily with USP4 and USP11 related through a shared presence of N-terminal "domain present in ubiquitin specific proteases" (DUSP) and "..