uPAR

Summary

Gene Symbol: uPAR
Description: plasminogen activator, urokinase receptor
Alias: CD87, U-PAR, UPAR, URKR, urokinase plasminogen activator surface receptor, monocyte activation antigen Mo3, u-plasminogen activator receptor form 2, urokinase-type plasminogen activator (uPA) receptor
Species: human

Top Publications

  1. ncbi Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer
    M V Carriero
    National Cancer Institute, Naples, Italy
    Cancer Res 59:5307-14. 1999
  2. pmc Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer
    Peter Buchler
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Neoplasia 11:196-206. 2009
  3. pmc Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
    Changli Wei
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Med 17:952-60. 2011
  4. doi Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases
    Martin Illemann
    The Finsen Laboratory, Rigshospitalet, Ole Maaløes Vej 5, Copenhagen N, Denmark
    Int J Cancer 124:1860-70. 2009
  5. pmc Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells
    Aamir Ahmad
    Department of Pathology, Barbara Ann Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 108:916-25. 2009
  6. ncbi The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants
    N Behrendt
    Finsen Laboratory, Righospitalet, Copenhagen, Denmark
    J Biol Chem 265:6453-60. 1990
  7. ncbi An anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope
    Yongdong Li
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yang Qiao Xi Lu, Fuzhou 350002, People s Republic of China
    J Mol Biol 365:1117-29. 2007
  8. pmc uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells
    Robin D Lester
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 178:425-36. 2007
  9. doi Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer
    Charlotte E Almasi
    The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    Prostate 71:899-907. 2011
  10. doi Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence Istituto Toscano Tumori, Florence, Italy
    Blood 118:3743-55. 2011

Research Grants

  1. Small-molecule Inhibition of the Interactions of the Urokinase Receptor: A Targe
    Samy Meroueh; Fiscal Year: 2012
  2. Engineered HSV For Treatment of Malignant Glioma
    Richard J Whitley; Fiscal Year: 2013
  3. WOUND HEALING ANGIOGENESIS
    Frank Isik; Fiscal Year: 2002
  4. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2012
  5. SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2016
  6. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
  7. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012
  8. Steven L Gonias; Fiscal Year: 2014
  9. Robert J Parmer; Fiscal Year: 2016
  10. Lily Yang; Fiscal Year: 2015

Detail Information

Publications267 found, 100 shown here

  1. ncbi Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer
    M V Carriero
    National Cancer Institute, Naples, Italy
    Cancer Res 59:5307-14. 1999
    ..Recent studies indicate that the urokinase receptor (uPAR) is associated in large molecular complexes with other molecules, such as integrins...
  2. pmc Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer
    Peter Buchler
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Neoplasia 11:196-206. 2009
    Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players...
  3. pmc Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
    Changli Wei
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Med 17:952-60. 2011
    ..plasmapheresis, or by interfering with the suPAR-β(3) integrin interaction through antibodies and small molecules targeting either uPAR or β(3) integrin. Our study identifies serum suPAR as a circulating factor that may cause FSGS.
  4. doi Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases
    Martin Illemann
    The Finsen Laboratory, Rigshospitalet, Ole Maaløes Vej 5, Copenhagen N, Denmark
    Int J Cancer 124:1860-70. 2009
    ..Plasmin(ogen) is activated on cell surfaces by urokinase-type PA (uPA), and is regulated by uPAR and plasminogen activator inhibitor-1 (PAI-1)...
  5. pmc Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells
    Aamir Ahmad
    Department of Pathology, Barbara Ann Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 108:916-25. 2009
    ..The urokinase plasminogen activator (uPA) and its receptor (uPAR) system are involved in the degradation of basement membrane and extracellular matrix, leading to tumor cell ..
  6. ncbi The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants
    N Behrendt
    Finsen Laboratory, Righospitalet, Copenhagen, Denmark
    J Biol Chem 265:6453-60. 1990
    ....
  7. ncbi An anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope
    Yongdong Li
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yang Qiao Xi Lu, Fuzhou 350002, People s Republic of China
    J Mol Biol 365:1117-29. 2007
    Human urokinase-type plasminogen activator receptor (uPAR/CD87) is expressed at the invasive interface of the tumor-stromal microenvironment in many human cancers and interacts with a wide array of extracellular molecules...
  8. pmc uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells
    Robin D Lester
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 178:425-36. 2007
    ..Hypoxia-induced EMT is accompanied by increased expression of the urokinase-type plasminogen activator receptor (uPAR) and activation of cell signaling factors downstream of uPAR, including Akt and Rac1...
  9. doi Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer
    Charlotte E Almasi
    The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    Prostate 71:899-907. 2011
    The purpose of this study was to investigate the prognostic value of different forms of the urokinase receptor, uPAR, in serum from prostate cancer (PC) patients.
  10. doi Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence Istituto Toscano Tumori, Florence, Italy
    Blood 118:3743-55. 2011
    Endothelial urokinase-type plasminogen activator receptor (uPAR) is thought to provide a regulatory mechanism in angiogenesis...
  11. doi Urokinase receptor associates with myocardin to control vascular smooth muscle cells phenotype in vascular disease
    Yulia Kiyan
    Nephrology Department, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Arterioscler Thromb Vasc Biol 32:110-22. 2012
    The urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) are a potent multifunctional system involved in vascular remodeling...
  12. pmc Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer
    Sanaz Memarzadeh
    Departments of Obstetrics and Gynecology, Pathology, and Medicine and Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:10647-52. 2002
    ..In this study, we examined whether urokinase plasminogen activator receptor (UPAR), a glycosyl-phosphatidylinositol-linked membrane protein, is a candidate diagnostic or prognostic marker for ..
  13. ncbi The cleavage of the urokinase receptor regulates its multiple functions
    Nunzia Montuori
    Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via Pansini 5, I 80131, Naples, Italy
    J Biol Chem 277:46932-9. 2002
    The urokinase-type plasminogen activator (uPA) is able to cleave its cell surface receptor (uPAR) anchored to the cell membrane through a glycophosphatidylinositol tail...
  14. pmc Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding
    Ying Wei
    Department of Medicine and Pulmonary and Critical Care Division, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 168:501-11. 2005
    ..Binding of uPAR to the beta-propeller of alpha3beta1 empowers vitronectin adhesion by this integrin...
  15. pmc An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration
    Roberta Mazzieri
    Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and S Raffaele Scientific Institute, 20132 Milan, Italy
    Mol Biol Cell 17:367-78. 2006
    Urokinase-type plasminogen activator (uPA) binding to uPAR induces migration, adhesion, and proliferation through multiple interactions with G proteins-coupled receptor FPRL1, integrins, or the epidermal growth factor (EGF) receptor (EGFR)..
  16. ncbi Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor
    Matthias Kotzsch
    Institute of Pathology, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
    Breast Cancer Res Treat 111:229-40. 2008
    To evaluate the pure prognostic impact of the uPA-receptor splice variant uPAR-del4/5 for lymph node-negative breast cancer patients, and to identify differentially expressed genes associated with high or low uPAR-del4/5 mRNA levels.
  17. pmc Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression
    Supurna Ghosh
    Department of Surgery, Northwestern University Feinberg Medical School, Chicago, Illinois, USA
    Mol Cancer Res 8:145-58. 2010
    ..analyses of primary oral tumors have identified urinary-type plasminogen activator (uPA) and its receptor (uPAR) as key genes associated with human OSCC progression...
  18. ncbi Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor
    Annapaola Andolfo
    Department of Molecular Pathology and Medicine, Molecular Genetics Unit, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Thromb Haemost 88:298-306. 2002
    ..activator receptor (uPA(R)) prevents the binding of uPA and vitronectin while generating biologically active uPAR fragments...
  19. ncbi The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis
    Daniela Alfano
    Institute of Genetics and Biophysics, Adriano Buzzati Traverso, CNR, Naples, Italy
    Thromb Haemost 93:205-11. 2005
    ..The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through ..
  20. pmc uPAR-induced cell adhesion and migration: vitronectin provides the key
    Chris D Madsen
    FIRC Institute of Molecular Oncology IFOM, 20139 Milan, Italy
    J Cell Biol 177:927-39. 2007
    Expression of the membrane receptor uPAR induces profound changes in cell morphology and migration, and its expression correlates with the malignant phenotype of cancers...
  21. pmc Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway
    Christopher S Gondi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
    Int J Oncol 31:19-27. 2007
    Urokinase plasminogen activator (uPA) and its receptor (uPAR) play a major role in invasion and proliferation...
  22. ncbi Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways
    Supurna Ghosh
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:13021-9. 2006
    ..of integrin alpha3beta1 and enhanced production of urinary-type plasminogen activator (uPA) and its receptor (uPAR) relative to normal oral mucosa...
  23. pmc uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham NG7 2UH, UK
    Thorax 67:477-87. 2012
    The asthma-associated gene urokinase plasminogen activator receptor (uPAR) may be involved in epithelial repair and airway remodelling. These processes are not adequately targeted by existing asthma therapies...
  24. ncbi Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide
    Lucia Gargiulo
    Department of Experimental Oncology, National Cancer Institute, 80131 Naples, Italy
    J Biol Chem 280:25225-32. 2005
    The urokinase-type plasminogen activator receptor (uPAR) sustains cell migration through its capacity to promote pericellular proteolysis, regulate integrin function, and mediate chemotactic signaling in response to urokinase...
  25. ncbi Structure and ligand interactions of the urokinase receptor (uPAR)
    Magnus Kjaergaard
    Finsen Laboratory, Rigshospitalet section 3735, Copenhagen Biocenter room 3 3 31, Ole Maaloes Vej 5, DK 2200 Copenhagen N, Denmark
    Front Biosci 13:5441-61. 2008
    The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the ..
  26. pmc Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins
    Chi Hui Tang
    Pulmonary and Critical Care Division, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 121:3747-56. 2008
    The urokinase receptor (uPAR) is upregulated upon tumor cell invasion and correlates with poor lung cancer survival...
  27. ncbi Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains
    Douglas G Walker
    Civin Laboratory of Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Brain Res 926:69-79. 2002
    ..This receptor, also designated as CD87, is induced in response to a range of stimuli and is a marker of macrophage activation...
  28. doi The urokinase receptor (CD87) represents a central mediator of growth factor-induced endothelial cell migration
    Marina Poettler
    Clinical Division of Oncology, Department of Medicine I and Comprehensive Cancer Center Vienna, Medical University Vienna, Austria
    Thromb Haemost 108:357-66. 2012
    ..Thus, VEGF165, VEGF-E, FGF-2, EGF as well as HGF induced a PI3k-dependent activation of pro-uPA when bound to uPAR, which led to an increase in cell surface fibrinolytic activity...
  29. pmc Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels
    Michael A Portelli
    2Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    FASEB J 28:923-34. 2014
    ..In summary, we reveal a novel post-translational regulatory mechanism for scuPAR using a hypothesis-free approach with implications for multiple human diseases...
  30. pmc Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study
    Martin C Boonstra
    Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    BMC Cancer 14:269. 2014
    The receptor for urokinase-type plasminogen activator (uPAR) is associated with cancer development and progression. Within the tumor microenvironment uPAR is expressed by malignant cells as well as tumor-associated stromal cells...
  31. ncbi Cell-surface acceleration of urokinase-catalyzed receptor cleavage
    G Høyer-Hansen
    Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    Eur J Biochem 243:21-6. 1997
    The urokinase-type plasminogen activator (uPA) binds to a specific cell-surface receptor, uPAR. On several cell types uPAR is present both in the full-length form and a cleaved form, uPAR(2+3), which is devoid of binding activity...
  32. ncbi Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction
    Andreas E May
    Medizinische Klinik des Klinikums Rechts der Isar und Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Blood 100:3611-7. 2002
    The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion by direct binding to vitronectin and by forming complexes with integrins...
  33. ncbi Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer
    Hiroyuki Konno
    Second Department of Surgery, Hamamatsu University School of Medicine, Japan
    Clin Exp Metastasis 19:527-34. 2002
    ..with CRC were assayed to determine the antigen levels of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2), as well as immunohistochemical expression of VEGF...
  34. ncbi Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G
    Nathalie Beaufort
    Unité de Défense Innée et Inflammation, Institut National de la Sante et de la Recherche Medicale, Equipe 336, Institut Pasteur, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    J Immunol 172:540-9. 2004
    The urokinase receptor (CD87) participates to the pericellular proteolytic potential of migrating cells and to the recruitment of leukocytes during inflammation...
  35. ncbi The urokinase receptor and the regulation of cell proliferation
    Roberta Mazzieri
    Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Thromb Haemost 93:641-6. 2005
    ..acting on the extracellular matrix components, and by regulating the activity of important signal transducers, uPAR participates not only in the modulation of cell-cell and cell-extracellular matrix interactions, but also in the ..
  36. pmc uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues
    Songdong Meng
    Cancer Immunobiology Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:17361-5. 2006
    ..The aims of this study were to determine whether urokinase plasminogen activator receptor (uPAR) gene amplification occurs and whether analysis of individual tumor cells (TCs) in the blood or tissue can add ..
  37. ncbi The human airway trypsin-like protease modulates the urokinase receptor (uPAR, CD87) structure and functions
    Nathalie Beaufort
    INSERM, E0336, Paris, France
    Am J Physiol Lung Cell Mol Physiol 292:L1263-72. 2007
    ..We have evaluated its capacity to affect the urokinase-type plasminogen activator receptor (uPAR), a membrane glycolipid-anchored, three-domain (D1D2D3) glycoprotein that plays a crucial role in innate immunity ..
  38. pmc Prognostic value analysis of urokinase-type plasminogen activator receptor in oral squamous cell carcinoma: an immunohistochemical study
    Roberta Bacchiocchi
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of the Marche Region, Ancona, Italy
    BMC Cancer 8:220. 2008
    ..involvement in other neoplasia, a crucial role is ascribed to the urokinase-type plasminogen activator receptor (uPAR), which plays a multiple role in extracellular proteolysis, cell migration and tissue remodelling not only as a ..
  39. ncbi Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion
    Charles Edo de Bock
    Leukaemia Foundation Research Laboratory, Queensland Institute of Medical Research, Herston, QLD, Australia
    Int J Oncol 36:1155-63. 2010
    The urokinase-type plasminogen activator receptor (uPAR) has diverse biological functions including roles in proteolysis, cell adhesion and cellular signaling...
  40. doi Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction
    Jing Xu
    FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Clin Sci (Lond) 119:353-9. 2010
    uPA (urokinase-plasminogen activator) and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of ..
  41. pmc Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
    Henrik Gardsvoll
    Finsen Laboratory, Rigshospitalet section 3735, Copenhagen Biocenter, Ole Maaløes Vej 5, DK 2200 Copenhagen N, Denmark
    J Biol Chem 286:33544-56. 2011
    The urokinase-type plasminogen activator receptor (uPAR) is a glycolipid-anchored membrane protein with an established role in focalizing uPA-mediated plasminogen activation on cell surfaces...
  42. doi RhoB regulates uPAR signalling
    Daniela Alfano
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London, UK
    J Cell Sci 125:2369-80. 2012
    Urokinase-type plasminogen activator (uPA) and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion...
  43. doi uPAR regulates pericellular proteolysis through a mechanism involving integrins and fMLF-receptors
    Nunzia Montuori
    Department of Cellular and Molecular Biology and Pathology, Federico II University, Naples, Italy
    Thromb Haemost 109:309-18. 2013
    The expression of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR) can be regulated by several hormones, cytokines, and tumour promoters...
  44. doi Urokinase receptor orchestrates the plasminogen system in airway epithelial cell function
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, NG7 2UH, UK
    Lung 191:215-25. 2013
    ..The relative contribution of each component to epithelial function is unclear. We characterized normal cell function in airway epithelial cells with increased expression of selected pathway components...
  45. ncbi Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction
    M Yebra
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, IMM13, La Jolla, California, 92037, USA
    Exp Cell Res 250:231-40. 1999
    Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) participate in matrix degradation and cell migration by focusing proteolysis and functioning as a signaling ligand/receptor complex...
  46. doi Urokinase receptor (uPAR) regulates complement receptor 3 (CR3)-mediated neutrophil phagocytosis
    Boris K Pliyev
    Department of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Moscow State University, Lomonosovsky Pr, 31 5, Moscow 119192, Russia
    Biochem Biophys Res Commun 397:277-82. 2010
    Urokinase receptor (uPAR) associates in cis with complement receptor 3 (CR3). In the present study, we addressed whether this coupling regulates CR3-mediated phagocytosis...
  47. pmc Number and brightness image analysis reveals ATF-induced dimerization kinetics of uPAR in the cell membrane
    Christian Hellriegel
    Microscopy and Dynamic Imaging Unit, National Center for Cardiovascular Research CNIC, Madrid, Spain
    FASEB J 25:2883-97. 2011
    We studied the molecular forms of the GPI-anchored urokinase plasminogen activator receptor (uPAR-mEGFP) in the human embryo kidney (HEK293) cell membrane and demonstrated that the binding of the amino-terminal fragment (ATF) of urokinase ..
  48. ncbi Differential localization and expression of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitor (PAI-1) mRNA and protein in endometrial tissue during the menstrual cycle
    J Nordengren
    Department of Gynaecology and Obstetrics, University Hospital, Lund, Sweden
    Mol Hum Reprod 10:655-63. 2004
    ..plasminogen activator (uPA)-dependent proteolytic cascade as well as ligand activation of the uPA receptor (uPAR) is critically involved in physiological as well as pathophysiological aspects of tissue expansion and remodelling...
  49. pmc The prognostic value of the suPARnostic ELISA in HIV-1 infected individuals is not affected by uPAR promoter polymorphisms
    Uffe V Schneider
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
    BMC Infect Dis 7:134. 2007
    ..to: 1) Evaluate the prognostic value of the new suPARnostic assay and 2) Determine whether polymorphisms in the active promoter of uPAR influences survival and/or suPAR values in HIV-1 patients who are antiretroviral therapy (ART) naive.
  50. pmc Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness
    Lauren Bryan
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Mol Cancer Res 6:1469-77. 2008
    ..the urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1), and a receptor for uPA (uPAR)...
  51. pmc A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR
    Elizabeth Monaghan-Benson
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 121:3693-703. 2008
    ..The mechanism of uPAR-mediated signaling across the membrane and the molecular basis of uPAR-dependent activation of integrins remain ..
  52. doi Plasminogen activator inhibitor variants PAI-1 A15T and PAI-2 S413C influence lung cancer prognosis
    Maria Chiara Di Bernardo
    Section of Cancer Genetics, Brookes Lawley Building, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    Lung Cancer 65:237-41. 2009
    ..An association was also detected between OS in NSCLC and carrier status for PAI-2 413C (HR=1.13; 95% CI: 1.01-1.24). These common genetic variants identified warrant further evaluation as promising prognostic markers of patient outcome...
  53. ncbi Tumor stroma is the predominant uPA-, uPAR-, PAI-1-expressing tissue in human breast cancer: prognostic impact
    Ralf Hildenbrand
    Institute of Pathology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Histol Histopathol 24:869-77. 2009
    Urokinase-type plasminogen activator (uPA), its receptor (uPAR) and its inhibitor PAI-1, play a key role in tumor invasion and metastasis...
  54. doi Urokinase receptor, MMP-1 and MMP-9 are markers to differentiate prognosis, adenoma and carcinoma in thyroid malignancies
    Daniel Buergy
    Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Mannheim Faculty, University of Heidelberg, and DKFZ Heidelberg, Mannheim, Germany
    Int J Cancer 125:894-901. 2009
    ..This is the first study to suggest MMP-1/-9 as significant differentiation markers between follicular adenoma and follicular carcinoma...
  55. doi MSP-induced RON activation upregulates uPAR expression and cell invasiveness via MAPK, AP-1 and NF-κB signals in gastric cancer cells
    Jung Sun Park
    Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju 501 190, Korea
    Carcinogenesis 32:175-81. 2011
    Overexpression of recepteur d'Origine nantais (RON) and urokinase plasminogen activator receptor (uPAR) have been observed in human gastric cancers. However, the interaction between RON and uPAR in gastric cancer is unclear...
  56. doi Concentrations of plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in induced sputum of asthma patients after allergen challenge
    Krzysztof Kowal
    Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
    Folia Histochem Cytobiol 48:518-23. 2010
    ..Greater increase of the PAI-1 concentration than uPA concentration after allergen challenge may promote airway remodeling and play an important role in the development of bronchial hyperreactivity...
  57. ncbi Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    Ying Wei
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    J Biol Chem 282:3929-39. 2007
    ..Thus urokinase receptor binding to alpha5beta1 is required for maximal responses to fibronectin and tumor cell invasion, and this operates through an enhanced Src/Rac/ERK signaling pathway...
  58. pmc Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
    Hoanh Tran
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, CH 4058 Basel, Switzerland
    Mol Cell Biol 23:7177-88. 2003
    The mRNAs of urokinase plasminogen activator (uPA) and its receptor, uPAR, contain instability-determining AU-rich elements (AREs) in their 3' untranslated regions...
  59. pmc Simultaneous downregulation of uPAR and MMP-9 induces overexpression of the FADD-associated protein RIP and activates caspase 9-mediated apoptosis in gliomas
    Christopher S Gondi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
    Int J Oncol 33:783-90. 2008
    ..of simultaneous RNA interference (RNAi)-mediated downregulation of urokinase-type plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9) in inhibiting tumor invasion in vitro and in vivo...
  60. doi The plasminogen activator system and cancer
    Brandon McMahon
    Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Pathophysiol Haemost Thromb 36:184-94. 2008
    ..Though both plasminogen activators, tPA and uPA, are expressed in tumor cells, uPA with its receptor (uPAR) is mostly involved in cellular functions, while tPA with its receptor annexin II on endothelial surface regulates ..
  61. ncbi Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization
    Carmine Selleri
    Division of Hematology, Istituto di Endocrinologia ed Oncologia Sperimentale IEOS, Consiglio Nazionale delle Ricerche, Via Pansini 5, I 80131, Naples, Italy
    Blood 105:2198-205. 2005
    We investigated the involvement of the urokinase-type plasminogen-activator receptor (uPAR) in granulocyte-colony-stimulating factor (G-CSF)-induced mobilization of CD34+ hematopoietic stem cells (HSCs) from 16 healthy donors...
  62. ncbi The prognostic value of the topographic distribution of uPAR expression in invasive breast carcinomas
    I Giannopoulou
    Department of Pathology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 115 27 Athens, Greece
    Cancer Lett 246:262-7. 2007
    uPA system plays an important role in cancer invasion and metastasis. The binding of uPA to its receptor, uPAR, is necessary for the activation of uPA system...
  63. ncbi Altered expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in high-risk soft tissue sarcomas
    M S Benassi
    Laboratory of Oncology Research, Rizzoli Orthopaedic Institute, Bologna, Italy
    Histol Histopathol 22:1017-24. 2007
    ..fibrous histiocytomas, to evaluate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1). Immunohistochemistry of gene products was also performed...
  64. pmc Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR
    Katia Cortese
    Centro di Ricerca MicroSCoBio IFOM, FIRC Institute of Molecular Oncology, Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Universita di Genova, Genova, Italy
    PLoS ONE 3:e3730. 2008
    The urokinase receptor (uPAR/CD87) is highly expressed in malignant tumours...
  65. pmc Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines
    Hari Raghu
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
    PLoS ONE 5:e12458. 2010
    In our earlier reports, we showed that downregulation of uPA and uPAR inhibited glioma tumor angiogenesis in SNB19 cells, and intraperitoneal injection of a hairpin shRNA expressing plasmid targeting uPA and uPAR inhibited angiogenesis in ..
  66. doi Soluble urokinase plasminogen activator receptor is associated with subclinical organ damage and cardiovascular events
    T Sehestedt
    Cardiovascular Research Unit, Department of Internal Medicine, Copenhagen University Hospital, Nordre Ringvej 57, 2600 Glostrup, Denmark
    Atherosclerosis 216:237-43. 2011
    ..We wanted to investigate whether suPAR was associated with markers of subclinical organ damage...
  67. ncbi Expression of urokinase-type plasminogen activator receptor (uPAR) in primary central nervous system neoplasms
    Mohammad Salajegheh
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Appl Immunohistochem Mol Morphol 13:184-9. 2005
    The cellular receptor for urokinase-type plasminogen activator receptor (uPAR) is a member of the glycosylphosphatidylinositol (GPI) anchored protein family...
  68. ncbi Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity
    Zonggao Shi
    Department of Pathology and Anatomical Sciences, M214E Medical Sciences Building, University of Missouri, 1 Hospital Drive, Columbia, MO 65212, USA
    Biochem J 407:153-9. 2007
    ..The proteinase uPA binds a surface-anchored receptor designated uPAR (uPA receptor), focalizing proteolytic activity to the pericellular milieu...
  69. ncbi Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue
    Pernille Autzen Usher
    The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    Int J Cancer 113:870-80. 2005
    ..We have studied the expression of urokinase-type plasminogen activator (uPA) mRNA, uPA receptor (uPAR) mRNA and immunoreactivity, and type-1 plasminogen activator inhibitor (PAI-1) mRNA and immunoreactivity in 16 ..
  70. ncbi uPAR mediates anticancer activity of PEDF
    Crispin R Dass
    Department of Orthopaedics, St Vincent s Hospital Melbourne, University of Melbourne, Australia
    Cancer Biol Ther 7:1262-70. 2008
    ..In parallel, we have also shown using rodent cells, the beneficial effects of downregulation of uPAR against OS...
  71. pmc Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor
    M V Cubellis
    Institute of Microbiology, University of Copenhagen, Denmark
    Proc Natl Acad Sci U S A 86:4828-32. 1989
    ..The possibility that in adherent cells a different localization of PAI-1 and uPA leads to protection of uPA from PAI-1 is to be considered...
  72. ncbi A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene
    E Soravia
    Department of Genetics and Microbiology, University of Milano, Italy
    Blood 86:624-35. 1995
    The urokinase-type plasminogen activator receptor (uPAR) focuses at the cell surface the activation of pro-uPA and, hence, the formation of plasmin, thus enhancing directional extracellular proteolysis...
  73. ncbi The structure of the urokinase-type plasminogen activator receptor gene
    J R Casey
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710
    Blood 84:1151-6. 1994
    The cellular receptor for urokinase-type plasminogen activator (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a central role in pericellular plasminogen activation...
  74. ncbi An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator
    C Pyke
    Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    FEBS Lett 326:69-74. 1993
    ..of cDNA ends), we have isolated a cDNA variant for the receptor for human urokinase plasminogen activator (uPAR)...
  75. pmc Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity
    R P Czekay
    Department of Cellular and Molecular Medicine, San Diego, La Jolla, California 92093 0651, USA
    Mol Biol Cell 12:1467-79. 2001
    ..internalization of urokinase:plasminogen activator inhibitor complexes (uPA:PAI-1) and the urokinase receptor (uPAR)...
  76. ncbi Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR)
    H Zhang
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Inflamm Res 52:86-93. 2003
    The goal of this study is to investigate the consequence of the interaction between Mac-1 and uPAR and determine the mechanisms by which uPAR regulates Mac-1 dependent adhesion to fibrinogen.
  77. ncbi Sequences within domain II of the urokinase receptor critical for differential ligand recognition
    Yang Li
    Department of Vascular Biology, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:29925-32. 2003
    The receptor for urokinase-type plasminogen activator (uPAR) plays important roles in a number of physiological and pathological processes by virtue of its interactions with urokinase-type plasminogen activator (uPA), vitronectin (Vn), ..
  78. ncbi Lipid raft compartmentalization of urokinase receptor signaling in human neutrophils
    Robert G Sitrin
    Pulmonary and Critical Medicine Division, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 30:233-41. 2004
    Urokinase plasminogen activator (uPA) receptors (uPAR) can be engaged for activation signaling either by aggregation or by binding exogenous uPA...
  79. ncbi Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator
    Minji Jo
    Department of Pathology, University of California San Diego School of Medicine, La Jolla, California 92093, USA
    J Biol Chem 280:17449-57. 2005
    The urokinase-type plasminogen activator (uPA) receptor (uPAR) functions in concert with co-receptors, including integrins, FPR-like receptor-1/lipoxin A4 receptor, and the epidermal growth factor receptor (EGFR), to initiate cell ..
  80. ncbi Specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas
    Sajani S Lakka
    Departments of Biomedical and Therapeutic Sciences Program of Cancer Biology, College of Medicine, University of Illinois, Peoria, IL 61656, USA
    J Biol Chem 280:21882-92. 2005
    ..the effectiveness of adenovirus-mediated expression of antisense urokinase-type plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9) in inhibiting tumor invasion in vitro and ex vivo...
  81. ncbi Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor
    Bernard Degryse
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 280:24792-803. 2005
    We investigated the interaction between the urokinase receptor (uPAR) and the integrin alphavbeta3. Vitronectin (VN) induces cell migration by binding to alphavbeta3, but expression of the uPAR boosts its efficacy...
  82. pmc Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta
    Julia Kiyan
    Nephrology Department, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    EMBO J 24:1787-97. 2005
    ..However, how intracellular signaling is linked to glycolipid-anchored uPA receptor (uPAR) is unknown...
  83. pmc RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo
    Sai MuraliKrishna Pulukuri
    Department of Biomedical and Therapeutic Sciences Program of Cancer Biology, University of Illinois College of Medicine, Peoria, Illinois 61656, USA
    J Biol Chem 280:36529-40. 2005
    ..Urokinase plasminogen activator-(uPA) and its receptor (uPAR)-mediated signaling have been implicated in tumor cell invasion, survival, and metastasis in a variety of cancers...
  84. pmc siRNA-mediated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells
    Ramesh Subramanian
    Division of Cancer Biology, Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, USA
    Int J Oncol 28:831-9. 2006
    A wide variety of tumor cells exhibit overexpression of urokinase plasminogen activator (uPA) and its receptor (uPAR). In breast cancer, expression of uPA and uPAR is essential for tumor cell invasion and metastasis...
  85. ncbi Urokinase signaling through its receptor protects against anoikis by increasing BCL-xL expression levels
    Daniela Alfano
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche CNR, Via P Castellino 111, 80131 Naples, Italy
    J Biol Chem 281:17758-67. 2006
    ..The binding of the serine protease urokinase (uPA) to its receptor (uPAR) plays a central role in the molecular events coordinating tumor cell adhesion, migration, and invasion...
  86. ncbi Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer
    Jörg H Leupold
    Department of Experimental Surgery Mannheim Faculty, University of Heidelberg, Heidelberg, Germany
    Mol Cancer Res 5:485-96. 2007
    ....
  87. pmc Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?
    G Deng
    Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 134:1563-71. 1996
    Induction of the urokinase type plasminogen activator receptor (uPAR) promotes cell adhesion through its interaction with vitronectin (VN) in the extracellular matrix, and facilitates cell migration and invasion by localizing uPA to the ..
  88. ncbi The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells
    I Dumler
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, 13125 Berlin, Germany
    J Biol Chem 273:315-21. 1998
    The binding of urokinase plasminogen activator (uPA) to its specific receptor (uPAR) facilitates migration of vascular smooth muscle cells (VSMC)...
  89. pmc Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction
    A Nykjaer
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus, Denmark
    J Cell Biol 141:815-28. 1998
    The urokinase-type plasminogen activator receptor (uPAR) plays an important role on the cell surface in mediating extracellular degradative processes and formation of active TGF-beta, and in nonproteolytic events such as cell adhesion, ..
  90. ncbi A urokinase receptor-associated protein with specific collagen binding properties
    N Behrendt
    Finsen Laboratory, Rigshospitalet, DK 2100 Copenhagen O, Denmark
    J Biol Chem 275:1993-2002. 2000
    ..This collagen binding reaction at the exact site of plasminogen activation on the cell may lead to adhesive functions as well as a contribution to cellular degradation of collagen matrices...
  91. ncbi Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function
    D I Simon
    Cardiovascular, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:10228-34. 2000
    ..One such protein, the glycolipid-anchored urokinase receptor (uPAR), associates with and modifies the function of the beta(2)-integrin Mac-1 (CD11b/CD18)...
  92. ncbi Ligand binding regions in the receptor for urokinase-type plasminogen activator
    O D Liang
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Leipzig Universität, Giessen, Germany
    J Biol Chem 276:28946-53. 2001
    The interaction between urokinase plasminogen activator (uPA) and its cellular receptor (uPAR) is a key event in cell surface-associated plasminogen activation, relevant for cell migration and invasion...
  93. pmc Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication
    Massimo Alfano
    AIDS Immunopathogenesis Unit, Department of Immunology and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina n 58, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 99:8862-7. 2002
    Elevated levels of soluble urokinase-type plasminogen activator (uPA) receptor, CD87/u-PAR, predict survival in individuals infected with HIV-1...
  94. ncbi Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton
    Vira V Artym
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Carcinogenesis 23:1593-601. 2002
    ..In this study we demonstrate that seprase and the urokinase plasminogen activator receptor (uPAR), co-localize in the plasma membrane of LOX malignant melanoma cells...
  95. ncbi Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration
    Elzbieta Pluskota
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, OH 44195, USA
    Blood 101:1582-90. 2003
    ..CD11b/18, Mac-1) forms a physical complex with the urokinase-type plasminogen activator receptor (uPAR/CD87) on leukocytes...
  96. ncbi Metabolism of tumour-derived urokinase receptor and receptor fragments in cancer patients and xenografted mice
    Cornelis F M Sier
    Department of Molecular Biology and Functional Genomics and FIRC Institute of Molecular Oncology, San Raffaele Scientific Institute and Hospital, Milan, Italy
    Thromb Haemost 91:403-11. 2004
    The urokinase-type plasminogen activator receptor (uPAR) is involved in cell migration and tissue remodelling, as a receptor for pro-uPA, as a cell adhesion component, and in a soluble form as a chemoattractant...
  97. ncbi Regulation of urokinase receptor proteolytic function by the tetraspanin CD82
    Rosemary Bass
    School of Biological Science, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 280:14811-8. 2005
    ..interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored cellular receptor (uPAR) promotes plasminogen activation and the efficient generation of pericellular proteolytic activity...
  98. ncbi High plasma levels of intact and cleaved soluble urokinase receptor reflect immune activation and are independent predictors of mortality in HIV-1-infected patients
    Sisse Rye Ostrowski
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, DK 2100 Denmark
    J Acquir Immune Defic Syndr 39:23-31. 2005
    ..This study investigated plasma levels of suPAR(I-III), suPAR(II-III), and 1-domain suPAR [suPAR(I)] and their predictive value for survival in HIV patients...
  99. pmc Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
    Paola Llinas
    CEA, Departement d Ingenierie et d Etudes des Proteines, CE Saclay, Gif sur Yvette, France
    EMBO J 24:1655-63. 2005
    We report the crystal structure of a soluble form of human urokinase-type plasminogen activator receptor (uPAR/CD87), which is expressed at the invasive areas of the tumor-stromal microenvironment in many human cancers...
  100. ncbi Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biochem 272:107-18. 2005
    Increased urokinase receptor (uPAR) expression as well as stabilisation of uPAR mRNA contribute to the pathogenesis of lung inflammation and neoplasia...
  101. ncbi Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma
    Pia Lindberg
    Department of Oral Pathology, Center for Oral Health Science, Malmo University, Sweden
    Int J Cancer 118:2948-56. 2006
    ..We have studied the expression of plasminogen activator inhibitor-1 (PAI-1) and urokinase receptor (uPAR) together with the gamma2-chain of laminin-5 (lam-gamma2) by immunohistochemistry in 20 cases with incipient oral ..

Research Grants65

  1. Small-molecule Inhibition of the Interactions of the Urokinase Receptor: A Targe
    Samy Meroueh; Fiscal Year: 2012
    PROJECT SUMMARY/ABSTRACT The urokinase receptor (uPAR) is a GPI-anchored protein that serves as a receptor to the serine protease urokinase (uPA)...
  2. Engineered HSV For Treatment of Malignant Glioma
    Richard J Whitley; Fiscal Year: 2013
    ..constitutively activated MEK (caMEK), IL12 and are re-targeted to unique cell surface receptors (IL13Ralpha2, uPAR, Grp78 or CD133) expressed specifically and at high abundance on glioma cells in situ;a wild-type HSV that is ..
  3. WOUND HEALING ANGIOGENESIS
    Frank Isik; Fiscal Year: 2002
    ..Vitronectin can bind free PAI-1 , and this complex can bind to the endothelial cell surface receptor for uPA, uPAR. Competition for uPAR determines the balance between fibrinolysis and inhibition...
  4. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2012
    ..as well as the activity of PC cell surface-associated urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR)...
  5. SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Though the secreted Ly6/urokinase type plasminogen activator receptor (uPAR) related protein-1 (Slurp1) is one of the most abundantly expressed proteins in the cornea and is secreted into the tear ..
  6. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..The levels of uPAR and MMP-9 expression and cellular invasiveness were increased in irradiated medulloblastoma cells...
  7. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012
    ..the previous funding period, we discovered a novel role for the urokinase-type plasminogen activator receptor (uPAR) in the regulation of fibronectin matrix assembly in connective tissue cells...
  8. Steven L Gonias; Fiscal Year: 2014
    ..cell- signaling indirectly by controlling cell-surface levels of other receptors, including the urokinase receptor (uPAR) and tumor necrosis factor receptor-1 (TNFR1)...
  9. Robert J Parmer; Fiscal Year: 2016
    ..imaging studies have noted prominent co-localization of Plg-RKT with ENaC, and with the urokinase receptor (uPAR), another key component of the plasminogen activation pathway...
  10. Lily Yang; Fiscal Year: 2015
    ..First, urokinase plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) will be validated as molecular targets for targeted therapeutics using ..
  11. Urokinase plasminogen activator receptor associated protein and acute lung injury
    Michael Bundesmann; Fiscal Year: 2010
    ..Second, it binds uPAR (urokinase plasminogen activator receptor), and may decrease uPA (urokinase plasminogen activator) activation...
  12. Nancy M Dahms; Fiscal Year: 2016
    ..CI-MPR also binds the non-M6P-containing ligands plasminogen, urokinase-type plasminogen activator receptor (uPAR), insulin-like growth factor-II (IGF-II), and retinoic acid...
  13. Sergei A Grando; Fiscal Year: 2014
    ..induced by the novel cholinergic peptide SLURP-1 (secreted mammalian Ly-6/urokinase plasminogen activator receptor [uPAR]-related protein). Integrating structural and functional information about SLURP-1 vs...
  14. Steven L Gonias; Fiscal Year: 2016
    ..We have identified the urokinase-type plasminogen activator receptor (uPAR) as a cell-signaling receptor that may become activated to support GBM cell growth and survival when EGFR signaling ..
  15. Lily Yang; Fiscal Year: 2015
    ..The drug-nanoparticle complex will target the urokinase plasminogen activator receptor (uPAR), a cellular receptor highly expressed in pancreatic cancer and active tumor stromal cells, to facilitate the ..
  16. Shivendra Singh; Fiscal Year: 2016
    ..At the same time, expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) is significantly downregulated by BITC treatment...
  17. Lindsey A Miles; Fiscal Year: 2016
    ..for the major plasminogen activator synthesized by macrophages, the urokinase plasminogen activator receptor (uPAR) and physically associates with uPAR...
  18. Targeted Nanoprobes For Intraoperative optical Imaging of Breast Cancer Margins
    Lily Yang; Fiscal Year: 2012
    ..In this study, we will develop urokinase plasminogen activator receptor (uPAR) targeted near infrared (NIR) dye-labeled nanoparticles to deliver the imaging probes into breast tumors, the ..
  19. Folate Receptor-Mediated siRNA Delivery to Cancer Cells
    Faqing Huang; Fiscal Year: 2009
    ..their cellular delivery and functions, targeting a cancer cell marker, urokinase plasminogen activator receptor (uPAR)...
  20. Nuclear urokinase (uPA) regulates tumor cell proliferation and survival.
    Victoria Stepanova; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Urokinase plasminogen activator (uPA), its high affinity receptor (uPAR/CD87) and PA inhibitors (PAI's) are widely used biomarkers of malignant transformation, tumor growth, propensity to ..
  21. The Regulation of UPA and UPAR in Human Carcinoma Cells
    Shuang Huang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The overexpression of urokinase plasminogen activator (uPA) and its receptor (uPAR) is detected in various malignancies...
  22. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    ..the administration of an antisense message that downregulates the urokinase-type plasminogen activator-receptor (uPAR)-mediated proteolytic cascade involved in invasion, in combination with a tumor suppressor gone using adenovirus ..
  23. Role of Activated EGFR and COX-2 in Metastasis and Escape from Tumor Dormancy
    ANDREW GREGORY SIKORA; Fiscal Year: 2012
    ..Further, the T-HEp3 model demonstrates urkinase plasminogen activator (uPAR)-driven ligand-independent activation of EGFR resulting in intrinsic resistance to monoclonal antibodies (mAB) that ..
  24. Ivory Dean; Fiscal Year: 2014
    ..Extracelluar maspin regulates pro-urokinase plasminogen activator (pro-uPA), and its receptor, uPAR, at the cell surface...
  25. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
    ..Derangements of the regulation of plasminogen activator inhibitor -1 (PAI-1) and the urokinase receptor (uPAR) by pleural mesothelial cells appear to be critical determinants of locally impaired fibrinolysis and intrapleural ..
  26. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..to assess the potential role of thrombolytic proteases, receptors, and regulatory serpins, specifically uPA, uPAR, and PAI-1, as molecular targets in Inflammatory Vasculitic (TKD and GCTA) disease and to assess the potential for ..
  27. Dexing Zeng; Fiscal Year: 2014
    ..two low-density receptors that are over-expressed in pancreatic cancer, urokinase plasminogen activator receptor (uPAR) and CXC chemokine receptor 4 (CXCR4), will be prepared and evaluated in cells...
  28. TARGET SPECIFIC AND DRUG LOADED IRON OXIDE NANOPARTICLES FOR CANCER IMAGING AND
    Andrew Wang; Fiscal Year: 2009
    ..delivery of peptide-conjugated iron oxide nanoparticles targeting to urokinase plasminogen activator receptor (uPAR) leads to selective accumulation and internalization of the iron oxide nanoparticles in breast cancer cells...
  29. IMMUNE TROPHOBLAST INJURY
    Keith McCrae; Fiscal Year: 1992
    ..vessels may depend on their regulated production of urokinase-type plasminogen activator (uPA), uPA receptors (UPAR) and plasminogen activator inhibitors (PAis)...
  30. Targeting Urokinase Pathway for Breast Cancer Therapy
    Rakesh Kumar; Fiscal Year: 2003
    ..activator (uPA)-dependent pericellular proteolysis and invasion depends on the localization of uPA to its receptor, uPAR, blocking this interaction may also lead to inhibition of tumor progression and angiogenesis...
  31. HIV-Associated Dementia and the Urokinase Plasminogen Activation System
    Paola Cinque; Fiscal Year: 2007
    ..The uPA system is composed of uPA, its receptor uPAR, its inhibitors plasminogen activator inhibitor (PAI-1) and protease nexin-1 (PN-1), a second plasminogen activator ..
  32. JOHN P O'BRYAN; Fiscal Year: 2014
    ..Several studies, including ours, demonstrated that significantly increased levels of cath B and uPAR in malignant gliomas and radiation further activates cath B and uPAR molecules...
  33. Urokinase-type Plasminogen Activator System and Pancreatic Stellate Cells
    Aurelia Lugea; Fiscal Year: 2007
    ..Our preliminary studies demonstrate that components of the system (uPA, its receptor uPAR and its specific inhibitor PAI-1) are produced in culture-activated but not in freshly isolated quiescent PSC, ..
  34. Anne E Cress; Fiscal Year: 2015
    ..bone is dependent upon laminin binding integrins and regulated by novel pericellular proteolysis involving the uPA/uPAR axis. Early (and often clinically inapparent) bone metastasis can provide a sanctuary site for tumor cells...
  35. REGULATION OF EXTRACELLULAR PROTEOLYSIS BY SERPINS
    DANIEL KNAUER; Fiscal Year: 2004
    ..and two of its co-receptors, heparin sulfate proteoglycans (HSPG's) and the urinary plasminogen activator receptor (uPAR) in the differential catabolism of the SERPIN, protease nexin I (PN 1) in complex with different regulatory ..
  36. Regulation of Angiogenesis by Kininogen
    Keith R McCrae; Fiscal Year: 2013
    ..to home to neovasculature, the intrinsic "angiogenic potential" of mKng1-/- endothelial cells, the role of the uPAR as an "antiangiogenic" HKa receptor, and the importance of oxidative stress to the anti-endothelial cell effects of ..
  37. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin H Schmaier; Fiscal Year: 2013
    ..Preliminary studies indicate that factor XII (XII) has an outside-in signaling pathway mediated by uPAR that is blocked by high molecular weight kininogen (HK) that leads to cell proliferation, growth, and angiogenesis...
  38. The role of Pdcd4 in colorectal tumor progression
    Hsin Sheng Yang; Fiscal Year: 2013
    ..reversion of the invasive/metastatic ability by inhibiting 2-catenin/Tcf dependent transcription, verification of uPAR and c-Myc as the target genes of 2-catenin/Tcf dependent transcription, and inhibition of 2-catenin/Tcf4 dependent ..
  39. Lewis A Chodosh; Fiscal Year: 2014
    ..The specific aims of this application are to: 1) Determine the role of uPAR signaling in tumor dormancy and recurrence;and 2) Determine the mechanism of Snail-mediated mammary tumor ..
  40. Ralph D Sanderson; Fiscal Year: 2016
    ..master regulator of metastasis in myeloma by upregulating expression of several genes including VEGF, MMP-9 and uPA/uPAR that work in concert to drive metastasis...
  41. Regression of meningioma tumor growth by combination therapy
    Jasti S Rao; Fiscal Year: 2012
    ..Several studies, including ours, demonstrated significantly increased levels of uPA, uPAR, MMP- 9, and cathepsin B in malignant meningiomas...
  42. Ernst Lengyel; Fiscal Year: 2016
    ..mechanisms which promote OvCa dissemination involve the interaction of ????-integrin with the urokinase receptor (uPAR) Most of the results obtained during the previous funding period point towards a prominent role for the ????-..
  43. Jaime R Merchan; Fiscal Year: 2015
    ..The central hypothesis of this application is that selective viral uPAR targeting of tumor stroma/vasculature will significantly enhance the virus'effects against primary tumors and ..
  44. uPA/uPAR and Ro60 in the pathogenesis of congenital heart block
    PARASKEVI BRIASOULI; Fiscal Year: 2013
    ..Audrey Bernstein, an expert in the basic biology of the uPA/uPAR system under study. Further acquisition of scientific skills related to the research plan will be provided by Dr...
  45. Keping Xie; Fiscal Year: 2016
    ..Human pancreatic cancer cells are known to overexpress uPAR and its expression levels directly correlate with those of FoxM1...
  46. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
    ..that have pathophysiologic relevance in the central nervous system, including urokinase (uPA) and its receptor (uPAR), lipoprotein metabolites, and activated alpha2-macroglobulin...
  47. BLOOD-RETINAL BARRIER CHANGES IN RETINOPATHY
    Ruth B Caldwell; Fiscal Year: 2010
    ..seeks to develop new therapies for diabetic retinopathy by targeting the urokinase/urokinase receptor system (uPA/uPAR)...
  48. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA MC KEOWN LONGO; Fiscal Year: 2007
    ..the previous funding period, we discovered a novel role for the urokinase-type plasminogen activator receptor (uPAR) in the regulation of fibronectin matrix assembly in connective tissue cells...
  49. CELL SURFACE ANTIGENS ON HUMAN MACROPHAGES
    Robert Todd; Fiscal Year: 1999
    ..by the ligation of other phagocyte receptors such as FcgammaRIIIB (CD16b) and the urokinase receptor, uPA-R (CD87) (GPI-anchored molecules that lack cytoplasmic domains)...
  50. STRUCTURE/FUNCTION ANALYSIS OF THE UROKINASE RECEPTOR
    Douglas Cines; Fiscal Year: 2002
    ..We observed that the complex of single chain uPA (scuPA) and its receptor (uPAR) is enzymatically active, pro-adhesive and relatively resistant to PAI-1...
  51. Role of uPA and uPAR in Human Glioma Invasiveness
    JASTI RAO; Fiscal Year: 2009
    ..The hypotheses is: Regulation of uPAR and uPA expression in human gliomas via a plasmid/Ad construct expressing siRNA for and uPAR and uPA message will ..
  52. Microglial interactions with amyloid beta peptide
    Douglas Walker; Fiscal Year: 2003
    ..In specific aim 2, we will characterize the expression of the urokinase plasminogen activator receptor (uPAR) by microglia...
  53. PLASMINOGEN REGULATION BY ANNEXIN II TETRAMER
    DAVID WAISMAN; Fiscal Year: 2002
    ..of AIIt-dependent acceleration of tPA and uPA-dependent Pg activation, and examine the potential modulatory role of uPAR in this process...
  54. uPA RECEPTOR SIGNALING AND CELL MIGRATION
    Mark Davies; Fiscal Year: 2005
    ..Smooth muscle cell migration in response to uPA depends on its binding to uPAR, a unique cell surface receptor which is pertussis toxin sensitive and whose signaling involves G-protein ..
  55. UROKINASE KRINGLE-MEDIATED VASCULAR REMODELING
    Douglas Cines; Fiscal Year: 2003
    ..Studies in mice with targeted deletion of the genes for uPA and uPAR indicate that uPA induces transmembrane signaling through pathways discrete from those involved in binding to its ..
  56. CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASE
    Sreerama Shetty; Fiscal Year: 2004
    The urokinase (uPA)-urokinase receptor (uPAR) system is implicated in the pathogenesis of pulmonary inflammation and repair via proteolytic remodeling, regulation of cell migration and mitogenesis...
  57. Regulation of Lung Epithelial Fibrinolysis by Urokinase
    Sreerama Shetty; Fiscal Year: 2005
    ..cells contribute to remodeling of extravascular fibrin by elaboration of urokinase (uPA), the urokinase receptor (uPAR) and plasminogen activator inhibitor-1 (PAl-1)...
  58. The Role of Urokinase Receptor in Prostate Cancer Progression
    Inder Sehgal; Fiscal Year: 2007
    ..This application addresses the role of the urokinase system, specifically the role of the urokinase receptor (uPAR) in prostate cancer progression. In collaboration with Dr...
  59. Targeting the Apical Surface of Human Airway Epithelia
    PAOLA DRAPKIN; Fiscal Year: 2003
    ..The urokinase plasminogen activator receptor (uPAR) is apically expressed by human airway epithelia...
  60. Novel human anti-uPAR antibodies for the treatment of pancreatic cancer
    Xiaomin Fan; Fiscal Year: 2009
    ..studies is that metastasis involves both tumor and surrounding stromal tissue-derived uPA and its receptor, uPAR. We plan to use a proprietary yeast display library and competitive screening method to try and identify antibodies ..
  61. EFFECT OF SERINE PROTEASES BY RADIATION IN CNS INJURY
    JASTI RAO; Fiscal Year: 2004
    ..Our Specific Aims are: (1) Define the mechanisms responsible for radiation-induced uPA, uPAR, and PN-I by using in vitro solo and co-cultures of human astrocytes, glial, and cerebral microvascular endothelial ..
  62. PEPTIDE ANATGONISTS OF UROKINASE PLASMINOGEN ACTIVATOR
    TERENCE JONES; Fiscal Year: 2001
    ..peptide (Angstroms 36) that potently inhibits the binding of urokinase plasminogen activator (uPA) to its receptor (uPAR)...
  63. WATCHING TARGET CELL OXIDATION AND CYTOLYSIS
    HOWARD PETTY; Fiscal Year: 2001
    ..We will test the hypothesis that certain glycophospholipid-linked membrane proteins, such as urokinase receptors (uPAR), reversibly interact with CR3...
  64. POST-TRANSCRIPTIONAL REGULATION OF UPAR EXPRESSION
    Michael Sturgess; Fiscal Year: 2000
    ..Up regulation of the expression of uPAR has been shown to significantly contribute to these processes...
  65. Interaction of uPA/R and Integrins in Oral Cancer
    MARY SHARON STACK; Fiscal Year: 2010
    ..The proteinase uPA binds to a glycosylphosphatidyl inositol (GPI)-linked receptor, uPAR, whereupon it initiates zymogen activation cascades leading to proteolytic modification of basement membrane ..