UGT2B15

Summary

Gene Symbol: UGT2B15
Description: UDP glucuronosyltransferase family 2 member B15
Alias: HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8, UDP-glucuronosyltransferase 2B15, UDP glucuronosyltransferase 2 family, member 15, UDP glucuronosyltransferase 2 family, member B8, UDP glucuronosyltransferase 2 family, polypeptide B15, UDP glycosyltransferase 2B15, UDP gycosyltransferase 2 family, member B15, UDP-glucuronosyltransferase 2B8, UDP-glucuronosyltransferase UGT2B15, UDP-glucuronyltransferase, family 2, beta-15, uridine diphosphate glucuronosyltransferase 2 family, member B8, uridine diphosphate glycosyltransferase 2 family, member B15
Species: human

Top Publications

  1. ncbi Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population
    Hironobu Okugi
    Department of Urology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, 371 8511 Gunma, Japan
    Cancer Detect Prev 30:262-8. 2006
  2. ncbi Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates
    M D Green
    Department of Pharmacology, University of Iowa, Iowa City 52242
    Drug Metab Dispos 22:799-805. 1994
  3. ncbi Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene
    E Levesque
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Laval University, Quebec, Canada
    Pharmacogenetics 7:317-25. 1997
  4. ncbi An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer
    S L MacLeod
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Ann Surg Oncol 7:777-82. 2000
  5. ncbi A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk
    Andrea Gsur
    Division of Applied and Experimental Oncology, Institute of Cancer Research, University of Vienna, Austria
    Cancer Epidemiol Biomarkers Prev 11:497-8. 2002
  6. ncbi Prostate cancer and polymorphism D85Y in gene for dihydrotestosterone degrading enzyme UGT2B15: Frequency of DD homozygotes increases with Gleason Score
    Tine Hajdinjak
    Department of Urology, Maribor Teaching Hospital, Maribor, Slovenia
    Prostate 59:436-9. 2004
  7. ncbi Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer
    Jong Park
    Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
    J Urol 171:2484-8. 2004
  8. ncbi Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium
    Sarah Chouinard
    Faculty of Medicine, Laval University, Quebec, Canada
    Endocr Res 30:717-25. 2004
  9. ncbi Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    Susan A Nowell
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 91:249-58. 2005
  10. ncbi The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men
    Charlotte Swanson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Goteborg University, SE 41345 Goteborg, Sweden
    J Clin Endocrinol Metab 92:4878-82. 2007

Research Grants

  1. Beverly H Koller; Fiscal Year: 2014
  2. Factors Determining Bisphenol A Disposition in Human Infants
    D Gail McCarver; Fiscal Year: 2013
  3. Pharmacogenetics of Tamoxifen and Chemotherapies and Risk of Contralateral Breast
    Jane C Figueiredo; Fiscal Year: 2010
  4. Kathleen E Malone; Fiscal Year: 2014
  5. Role of UDP-Glucuronosyltransferases in UV-mediated melanomagenesis
    RYAN WILLIAM DELLINGER; Fiscal Year: 2013
  6. Modification of tamoxifen effectiveness by gene polymorphisms and other drugs
    Timothy Lash; Fiscal Year: 2009
  7. Acetaminophen Pharmacogenetics
    Michael H Court; Fiscal Year: 2010
  8. Mechanisms of adverse host responses to antibiotics
    Michael Court; Fiscal Year: 2006
  9. Epigenetic Markers for Lung Cancer Detection
    Jong Park; Fiscal Year: 2006
  10. Foward Genetic Study of Surface Coat Genes Expression in Trypanosoma Brucei
    Gwo Shu Lee; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications152 found, 100 shown here

  1. ncbi Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population
    Hironobu Okugi
    Department of Urology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, 371 8511 Gunma, Japan
    Cancer Detect Prev 30:262-8. 2006
    ..Androgen plays a central role in the normal and malignant development of prostate glands. Genetic polymorphisms of genes involved in androgen metabolism and signaling might be associated with the risk of prostate cancer...
  2. ncbi Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates
    M D Green
    Department of Pharmacology, University of Iowa, Iowa City 52242
    Drug Metab Dispos 22:799-805. 1994
    ..Biochemistry 32, 10648-10657, 1993). HE8a is a member of the UGT2B gene family, and it has been designated UGT2B15. Over 100 compounds were tested for their reactivity with the expressed protein...
  3. ncbi Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene
    E Levesque
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Laval University, Quebec, Canada
    Pharmacogenetics 7:317-25. 1997
    ..Characterization of the UGT2B15(Y85) cDNA, which was isolated from human prostate and LNCaP cell cDNA libraries, revealed 20 nucleotide ..
  4. ncbi An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer
    S L MacLeod
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Ann Surg Oncol 7:777-82. 2000
    UDP-glucuronosyltransferase 2B15 (UGT2B15) catalyzes the inactivation of dihydrotestosterone (DHT) by forming the DHT-glucuronide and is expressed in normal and hyperplastic prostate tissue...
  5. ncbi A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk
    Andrea Gsur
    Division of Applied and Experimental Oncology, Institute of Cancer Research, University of Vienna, Austria
    Cancer Epidemiol Biomarkers Prev 11:497-8. 2002
  6. ncbi Prostate cancer and polymorphism D85Y in gene for dihydrotestosterone degrading enzyme UGT2B15: Frequency of DD homozygotes increases with Gleason Score
    Tine Hajdinjak
    Department of Urology, Maribor Teaching Hospital, Maribor, Slovenia
    Prostate 59:436-9. 2004
    Although, a functional rationale for influence of polymorphism D85Y in gene UGT2B15 on prostate cancer (PCa) exists (different V(max) of enzyme), conflicting results have been reported.
  7. ncbi Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer
    Jong Park
    Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
    J Urol 171:2484-8. 2004
    ..The UGT2B15 allele exhibits 2-fold decreased activity for dihydrotestosterone, which was suggested to be associated with the ..
  8. ncbi Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium
    Sarah Chouinard
    Faculty of Medicine, Laval University, Quebec, Canada
    Endocr Res 30:717-25. 2004
    ..These results demonstrate that, in the human prostate, UGT2B15 and UGT2B17 genes have complementary roles, and are expressed in cells where their specific substrates are ..
  9. ncbi Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    Susan A Nowell
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 91:249-58. 2005
    ..functional polymorphisms in CYP2D6, the P450 catalyzing the formation of active tamoxifen metabolites, and UGT2B15, a Phase II enzyme facilitating the elimination of active metabolite in a retrospective study of breast cancer ..
  10. ncbi The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men
    Charlotte Swanson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Goteborg University, SE 41345 Goteborg, Sweden
    J Clin Endocrinol Metab 92:4878-82. 2007
    ..Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and UGT2B17 glucuronidate androgens and their metabolites...
  11. ncbi UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells
    Sarah Chouinard
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center, Quebec G1V 4G2, Canada
    J Biol Chem 282:33466-74. 2007
    ..The presence of UGT2B15/B17 in the epithelial cells of the human prostate has been clearly demonstrated, and significant 3alpha-DIOL ..
  12. doi Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism
    Vincent Menard
    Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec CHUQ Research Center, and Pharmacy Department, Laval University, Quebec, Canada
    Hum Mutat 30:1310-9. 2009
    ..They are involved, along with UGT2B15, in the catabolism of sex-steroid hormones...
  13. pmc Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15
    Chang Sun
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Hum Mutat 31:99-107. 2010
    Allelic imbalance (AI) is a powerful tool to identify cis-regulatory variation for gene expression. UGT2B15 is an important enzyme involved in the metabolism of multiple endobiotics and xenobiotics...
  14. doi Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression
    Sophie Paquet
    Laboratory of Molecular Pharmacology, Centre Hospitalier Universitaire de Québec Research Centre and Faculty of Pharmacy, Laval University, 2705 Boulevard Laurier, Quebec QC, Canada G1V 4G2
    J Clin Endocrinol Metab 97:E428-32. 2012
    ..Androgens play major roles in prostate cancer initiation and development. In prostate cells, the human uridine diphosphate-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes inactivate androgens...
  15. ncbi Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8
    Aritoshi Iida
    Laboratory for Genotyping, RIKEN SNP Research Center, c o RIKEN Yokohama Institute, Kanagawa, Japan
    J Hum Genet 47:505-10. 2002
    ..found among 48 Japanese individuals in three uridine diphosphate glycosyltransferase (UGT) genes, UGT2A1, UGT2B15, and UGT8...
  16. ncbi Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily
    Matthew G Soars
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK
    Biochem Pharmacol 65:1251-9. 2003
    ..The following results were obtained: (i) sequence alignments between UGT2B31 and UGT2B15 gave the greatest degree of identity (76%); however, human UGT2B4, human UGT2B7, monkey UGT2B9 (all 75%), and rat ..
  17. ncbi Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Drug Metab Dispos 32:314-20. 2004
    ..Recombinant human UGT1A1, UGT1A3, and UGT2B15 all exhibited catalytic activity with respect to the formation of the phenolic glucuronide...
  18. ncbi Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform
    Hidefumi Kaji
    Exploratory Toxicology and DMPK Research Laboratories, Tanabe Seiyaku Co, Ltd, 2 2 50 Kawagishi, Toda Saitama 335 8505, Japan
    Drug Metab Dispos 33:403-12. 2005
    ..UGT) isoforms (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, UGT2B15, and UGT2B17), only UGT2B7 exhibited high denopamine glucuronosyltransferase activity...
  19. ncbi Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues
    A Belanger
    MRC Group in Molecular Endocrinology, CHUL Research Center and Laval University, Quebec, Canada
    J Steroid Biochem Mol Biol 65:301-10. 1998
    ..Recently, we have reported the tissue distribution of UGT2B15, which can conjugate steroids in several human extrahepatic steroid target tissues including the skin, breast and ..
  20. ncbi Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes
    Kenji Toide
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Pharmacol 67:1269-78. 2004
    ..activities were detectable with multiple UGT isoforms (UGT1A1, UGT1A3, UGT1A4, UGT2B4, UGT2B7, and UGT2B15)...
  21. doi Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol
    Päivi Lehtonen
    Faculty of Pharmacy, Division of Pharmaceutical Chemistry, University of Helsinki, FI 00014, Finland
    Eur J Pharm Sci 41:523-30. 2010
    ..Similar though not strict enantioselectivity was exhibited by UGT2B15. UGT2B7, on the other hand, glucuronidated both O-desmethyltramadol enantiomers, with slight preference for 1S,2S-..
  22. ncbi Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4
    D Turgeon
    Laboratory of Molecular Endocrinology, Laval University, Ontario, Canada M5G 2M9
    J Mol Biol 295:489-504. 2000
    ..b>UGT2B15 and UGT2B17 are 95% identical in primary structure, and are expressed in steroid target tissues where they ..
  23. pmc Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism
    Yi Jin
    Centers of Excellence in Environmental Toxicology and Cancer Pharmacology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    J Biol Chem 284:10013-22. 2009
    ..via the previously unrecognized "conjugation pathway" involving the sequential reactions of UGT2B17 and AKR1C4 in liver but via the conventional "reduction pathway" involving the sequential reactions of AKR1C2 and UGT2B15/17 in prostate.
  24. doi The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases
    Katriina Itäaho
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, P O Box 56 Viikinkaari 5, University of Helsinki, FIN 00014 Helsinki, Finland
    Drug Metab Dispos 36:2307-15. 2008
    ..b>UGT2B15 glucuronidated both estradiols at the 3-OH, with a strong preference for epiestradiol...
  25. pmc Gene expression profiles in liver of pigs with extreme high and low levels of androstenone
    Maren Moe
    The Norwegian Pig Breeders Association NORSVIN, Hamar, Norway
    BMC Vet Res 4:29. 2008
    ..In this study, microarrays were used to identify differentially expressed genes and pathways related to androstenone metabolism in the liver from boars with extreme levels of androstenone in adipose tissue...
  26. ncbi Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9
    Lalitha V Iyer
    Biopharmaceutical Division, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    Toxicol Sci 73:36-43. 2003
    ..94 +/- 0.188 pmols/min/mg), UGT1A9 (51.36 +/- 0.72 pmoles/min/mg), and UGT2B15 (8.18 +/- 0.037 pmoles/min/mg) were responsible for 1'-HEG formation...
  27. ncbi The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7
    K Bowalgaha
    Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, SA 5042, Australia
    Drug Metab Dispos 35:363-70. 2007
    ..In contrast, UGT2B15 and UGT2B17 were the major forms involved in human liver microsomal testosterone 17beta-glucuronidation and the ..
  28. ncbi Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer
    Julie M Cunningham
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:969-78. 2007
    ..Those genes tested included PRL, LHB, CYP11A1, HSD3B1, HSD3B2, HSD17B2, CYP17, SRD5A2, AKR1C3, UGT2B15, AR, SHBG, and KLK3 from the androgen pathway and CYP19, HSD17B1, CYP1A1, CYP1A2, CYP1B1, COMT, GSTP1, GSTT1, ..
  29. doi Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction
    Shuji Ohno
    Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Drug Metab Dispos 37:32-40. 2009
    ..We were surprised to find that extremely high expression in the liver was found for UGT2B4 and UGT2B15, which had, respectively, 8.98 and 4.38 times greater expression than UGT2B7 in the liver...
  30. ncbi Functions and transcriptional regulation of PAH-inducible human UDP-glucuronosyltransferases
    K W Bock
    Institute of Toxicology, University of Tubingen, Germany
    Drug Metab Rev 31:411-22. 1999
    Functions and regulation of selected human UDP-glucuronosyltransferases (UGT1A1, UGT1A4, UGT1A6, UGT1A9, UGT2B7, UGT2B15) are summarized...
  31. doi The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors
    Peter I Mackenzie
    Department of Clinical Pharmacology, Flinders Medical Science and Technology, Flinders University, Adelaide, South Australia, Australia
    Drug Metab Rev 42:99-109. 2010
    ..gene expression in the gastrointestinal tract, whereas the genes for the major androgen-glucuronidating enzymes, UGT2B15 and UGT2B17, are upregulated by estrogens in breast cell lines and downregulated by androgens in prostate-derived ..
  32. pmc Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid-conjugating protein
    O Barbier
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, 2705 Laurier Boulevard, Quebec, Canada G1V 4G2
    Biochem J 337:567-74. 1999
    ..Amino acid sequence alignment shows that the UGT2B20 protein is 92% identical with UGT2B15. Both enzymes have similar apparent Km values for DHT and 3alpha-Diol, and demonstrate similar transcript tissue ..
  33. ncbi Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:329-33. 2000
    ..We determined the prevalence of the UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y) polymorphisms in a sample of 233 individuals. The allele frequencies were significantly different (P < 0...
  34. ncbi The specificity of glucuronidation of entacapone and tolcapone by recombinant human UDP-glucuronosyltransferases
    P Lautala
    Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Helsinki, Finland
    Drug Metab Dispos 28:1385-9. 2000
    ..COMT inhibitors were glucuronidated at low rates by the representative members of the UGT2B family, UGT2B7 and UGT2B15. Michaelis-Menten parameters were determined for entacapone and tolcapone using recombinant human UGT isoforms ..
  35. ncbi Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms
    Miki Nakajima
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Drug Metab Dispos 30:636-42. 2002
    ..cells tested in the present study (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B15), only UGT1A4 showed imipramine N-glucuronosyltransferase activity...
  36. ncbi In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug
    Esther F A Brandon
    Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Invest New Drugs 24:3-14. 2006
    ..ET-743 glucuronidation, catalyzed by UGT2B15, was observed in microsomes and S9 fraction...
  37. ncbi Effect of chronic renal insufficiency on hepatic and renal udp-glucuronyltransferases in rats
    Chuanhui Yu
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA
    Drug Metab Dispos 34:621-7. 2006
    ..these catalytic activities were screened using recombinant rat UGT1A1, UGT1A2, UGT1A3, UGT1A7, UGT2B2, UGT2B3, and UGT2B8. UGT protein levels were examined by Western blot analysis using polyclonal antibodies...
  38. ncbi Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4
    Kenichiro Ogura
    Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, and Division of GI Oncology, National Cancer Center Hospital, Tokyo, Japan
    Biochem Pharmacol 71:1358-69. 2006
    ..recombinant human UGT isoforms (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, UGT2B15, and UGT2B17) expressed in insect cells...
  39. ncbi Valproic acid induces neuroendocrine differentiation and UGT2B7 up-regulation in human prostate carcinoma cell line
    Alessandra Valentini
    Department of Internal Medicine PTV, Consorzio interuniversitario per le Applicazioni di Supercalcolo Per Universitàe Ricerca CASPUR, Rome, Italy
    Drug Metab Dispos 35:968-72. 2007
    ..Even though UGT2B7 has only about one-tenth to one-hundredth the activity of UGT2B15 and 2B17 toward active androgens and we did not found any modulation in gene expression of these enzymes, it can ..
  40. pmc Glucuronidation of tobacco-specific nitrosamines by UGT2B10
    Gang Chen
    Penn State Cancer Institute, Hershey, PA 17033, USA
    Drug Metab Dispos 36:824-30. 2008
    ..overexpressing UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, and UGT2B17, only UGT1A4 and UGT2B10 exhibited N-glucuronidating activity against these TSNAs...
  41. doi Effects of Andrographis paniculata and Orthosiphon stamineus extracts on the glucuronidation of 4-methylumbelliferone in human UGT isoforms
    Sabariah Ismail
    Centre for Drug Research, Universiti Sains Malaysia, 11800, Penang, Malaysia
    Molecules 15:3578-92. 2010
    ..4MU) by recombinant human UGTs, UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A10, UGT2B7 and UGT2B15 were determined...
  42. ncbi Metabolism of parabens (4-hydroxybenzoic acid esters) by hepatic esterases and UDP-glucuronosyltransferases in man
    Suzanne Abbas
    UMR 7561 CNRS Université Henri Poincaré Nancy 1, School of Medicine, Vandoeuvre leà s Nancy, France
    Drug Metab Pharmacokinet 25:568-77. 2010
    ..They were mainly substrates of human recombinant UGT1A1, UGT1A8, UGT1A9, UGT2B7, UGT2B15 and UGT2B17...
  43. doi Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma
    T E Mürdter
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Clin Pharmacol Ther 89:708-17. 2011
    ..236 breast cancer patients were genotyped for CYP2D6, CYP2C9, CYP2B6, CYP2C19, CYP3A5, UGT1A4, UGT2B7, and UGT2B15; also, plasma concentrations of tamoxifen and 22 of its metabolites, including the (E)-, (Z)-, 3-, and 4'-..
  44. doi Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities
    Sumio Ohtsuki
    Division of Membrane Transport and Drug Targeting Laboratory, Department of Biochemical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku Sendai 980 8578, Japan
    Drug Metab Dispos 40:83-92. 2012
    ..CYP2C9, CYP2E1, CYP3A4, CYP2A6, UGT1A6, UGT2B7, UGT2B15, and P450R were abundantly expressed (more than 50 pmol/mg protein) in human liver microsomes...
  45. doi Functional UDP-glucuronyltransferase 2B15 polymorphism and bisphenol A concentrations in blood: results from physiologically based kinetic modelling
    Falko Partosch
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Luisenstr 7, 10117 Berlin, Germany
    Arch Toxicol 87:1257-64. 2013
    ..Using a validated human PBK model, this study investigated the influence of functionally relevant polymorphic UGT2B15, the enzyme mediating BPA metabolism, on the BPA concentration-time profile in human blood...
  46. doi A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar
    Frances Stringer
    Takeda Pharmaceutical Company, Osaka, Japan
    J Clin Pharmacol 54:453-61. 2014
    ..activated receptor agonist, are subject to high inter-individual variability resulting from a polymorphism of the UGT2B15 genotype...
  47. doi Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide
    Nicole Schwab
    Institute of Legal Medicine and Forensic Medicine, University Hospital, Voss Strasse 2, 69115, Heidelberg, Germany
    Anal Bioanal Chem 406:2325-32. 2014
    ..After co-incubation with both flavonoids, formation of EtG was significantly reduced for all enzymes except for UGT2B15, whose activity did not seem to be affected...
  48. doi Multiple roles for UDP-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution
    Louis Gauthier-Landry
    Laboratory of Molecular Pharmacology, CHU de Québec Research Centre, and the Faculty of Pharmacy, Laval University, Quebec, Canada
    J Steroid Biochem Mol Biol 145:187-92. 2015
    ..derivatives through the glucuronidation reaction involves 2 UDP-glucuronosyltransferase (UGT) enzymes, namely UGT2B15 and UGT2B17...
  49. doi Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines
    Dhilushi D Wijayakumara
    Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia
    J Pharmacol Exp Ther 354:417-25. 2015
    ..Although several studies provide evidence of transcriptional control of UGT2B15 and UGT2B17 by various endogenous and exogenous compounds, potential post-transcriptional regulation of UGT2B15 ..
  50. doi Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer
    Guillaume Margaillan
    Pharmacogenomics Laboratory, Centre Hospitalier Universitaire CHU de Québec Research Center, and Faculty of Pharmacy, Laval University, G1V 4G2 Quebec, Canada
    J Steroid Biochem Mol Biol 155:85-93. 2016
    ..local androgen bioavailability is controlled by UDP-glucuronosyltransferases conjugating enzymes (UGT), namely UGT2B15, UGT2B17 and UGT2B28...
  51. doi Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis
    Malin Hagberg Thulin
    Sahlgrenska Cancer Center, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Electronic address
    Mol Cell Endocrinol 422:182-91. 2016
    ..AKR1C3), estrogen signaling-related genes (CYP19A1, and ESR2), and genes for DHT-inactivating enzymes (UGT2B7, UGT2B15, and UGT2B17)...
  52. pmc Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism
    Peder Rustøen Braadland
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    Oncotarget 7:1878-94. 2016
    ..Two UDP-glucuronosyltransferases, UGT2B15 and UGT2B17, involved in phase II metabolism of androgens, were strongly downregulated in two LNCaP shADRB2 cell ..
  53. doi Formation and inhibition of ethyl glucuronide and ethyl sulfate
    Nicole Stachel
    Institute of Legal and Traffic Medicine, University Hospital, Voss Strasse 2, D 69115 Heidelberg, Germany
    Forensic Sci Int 265:61-4. 2016
    ..UGT1A1, UGT1A9 and HLM; quercetin and kaempferol were inhibitors of all transferases under investigation except UGT2B15. Findings for quercetin with regard to UGT2B7 and SULT2A1 and for kaempferol with regard to SULT1E1 and SULT2A1 ..
  54. doi Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Arctiin and Arctigenin
    Hui Zhang
    Department of Pharmacy, the Second Affiliated Hospital of Wenzhou Medical University, 109 XueYuan Western Road, Wenzhou, Zhejiang Province, P R China
    Phytother Res 30:1189-96. 2016
    ..Homology modeling-based in silico docking of arctiin and arctigenin into the activity cavity of UGT2B15 showed that hydrogen bonds and hydrophobic interactions contributed to the strong binding free energy of arctiin (..
  55. ncbi Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound
    Feng Li
    a Guangzhou Jinan Biomedicine Research and Development Center, Jinan University, Guangzhou, China
    Xenobiotica . 2016
    ..3. Among the three UGT enzymes (i.e., UGT1A1, UGT1A3 and UGT2B15) capable of catalyzing bakuchiol glucuronidation, UGT2B15 showed the highest activity with a CLint ..
  56. doi Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects
    Eisuke Miyauchi
    Membrane Transport and Drug Targeting Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Mol Pharm 13:2631-40. 2016
    ..Based on average values, UGT1A1, UGT2B15, UGT2B17, SGLT1, and GLUT2 exhibited high expression levels (over 10 fmol/μg protein), though UGT2B15 expression ..
  57. ncbi Genetic polymorphism of UDP-glucuronosyltransferase (UGT2B15) and glucuronidation of paracetamol in healthy population
    Huma Mehboob
    Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan
    Pak J Pharm Sci 29:1037-41. 2016
    Inter individual variability in polymorphic UDP-glucuronosyltransferase (UGT2B15) has been associated with varied glucuronidation level...
  58. ncbi Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17
    Dong G Hu
    Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, South Australia, Australia
    Cancer Res 76:5881-5893. 2016
    ..this study, the expression and regulation of two androgen-inactivating enzymes, the UDP-glucuronosyltransferases UGT2B15 and UGT2B17, was assessed in breast cancer...
  59. ncbi Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication
    Herjan Mijderwijk
    From the Departments of Anesthesiology and Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands
    Anesth Analg 123:1109-1115. 2016
    Lorazepam is used as premedication for its anxiolytic properties. The UGT2B15 genotype is of importance for the metabolism of lorazepam...
  60. ncbi Effects of UGT1A9 genetic polymorphisms on monohydroxylated derivative of oxcarbazepine concentrations and oxcarbazepine monotherapeutic efficacy in Chinese patients with epilepsy
    Yao Lu
    Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China
    Eur J Clin Pharmacol . 2016
    ..The interactions among UGT1A4, UGT1A6, UGT1A9, and UGT2B15 genetic polymorphisms, monohydroxylated derivative (MHD) of oxcarbazepine (OXC) plasma concentrations, and OXC ..
  61. pmc Developmental aspects of human hepatic drug glucuronidation in young children and adults
    C P Strassburg
    Department of Gastroenterology and Hepatology, Hannover Medical School, Germany
    Gut 50:259-65. 2002
    ..Hepatic glucuronidation undergoes significant changes during fetal and neonatal development requiring age adapted drug therapy. Regulation of individual UGT genes during hepatic development has not been defined...
  62. ncbi Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes
    Yoko Otake
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 30:576-81. 2002
    ..appeared to be catalyzed mainly by the UDP-glucuronosyltransferase (UGT)1A9 isoform but also by UGT1A1 and UGT2B15. Sulfation of galangin by the human liver cytosol, mediated mainly but not exclusively by sulfotransferase (SULT) ..
  63. ncbi Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases
    Takahito Nishiyama
    Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji shi, Tokyo 192 0392, Japan
    Biochem Pharmacol 63:1817-30. 2002
    ..UGTs1A1, 1A4, 1A9 and 2B7 had weak activity toward HO-TAMs with a much smaller cis-selectivity than did UGT2B15. UGTs1A3 and 1A6 had no detectable activity toward these substrates...
  64. ncbi N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases
    Omar Ghosheh
    Drug Metabolism and Drug Disposition Group, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Drug Metab Dispos 30:991-6. 2002
    ..by use of recombinant enzymes (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B15). Quantification was by radiochemical high-performance liquid chromatography with use of radiolabeled substrates...
  65. ncbi Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes
    Miki Nakajima
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Drug Metab Dispos 30:1250-6. 2002
    ..Any commercially available recombinant human UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, and UGT2B15) expressed in baculovirus-infected insect cells did not show detectable 4'-HPPH O-glucuronide...
  66. ncbi Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes
    Miki Nakajima
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Drug Metab Dispos 30:1484-90. 2002
    ..UDP-glucuronosyltransferases (UGTs) (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B15) expressed in baculovirus-infected insect cells or human B-lymphoblastoid cells that are commercially available ..
  67. ncbi Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme
    Mika Kurkela
    Viikki Drug Discovery Technology Center, University of Helsinki, Finland
    J Biol Chem 278:3536-44. 2003
    ..The activity of recombinant UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT2B4, UGT2B7, and UGT2B15 was almost fully inhibited by 0.2% Triton X-100...
  68. ncbi Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics
    David Turgeon
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche de l Université Laval, Laval University, Quebec City, Quebec, Canada
    Drug Metab Dispos 31:670-6. 2003
    ..is one of the most important conjugating enzymes in androgen metabolism and shares more than 95% homology with UGT2B15. Although UGT2B15 has been fully characterized for its ability to conjugate drugs, environmental pollutants, and ..
  69. ncbi The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferases
    Brian T Ethell
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Scotland, Dundee, UK
    Biochem Pharmacol 65:1441-9. 2003
    ..In addition to this the effect of valproic acid was investigated using two other UGT isoforms: UGT1A1 and UGT2B15 which do not glucuronidate valproic acid...
  70. ncbi Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15
    Willie Wilson
    Cancer Research Program, JLC Biomedical Biotechnology Research Institute, North Carolina Central University, 1801 Fayetteville Street, Durham, NC 27707, USA
    Genomics 84:707-14. 2004
    ..Two members of this family, UGT2B15 and UGT2B17, share over 95% sequence identity...
  71. ncbi Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
    Michael H Court
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, USA
    Methods Enzymol 400:104-16. 2005
    ..trifluoperazine (UGT1A4) serotonin (UGT1A6), propofol (UGT1A9), 3'-azidothymidine (UGT2B7), and S-oxazepam (UGT2B15)...
  72. ncbi Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation
    A I Loureiro
    Department of Research and Development, BIAL, A Av da Siderurgia Nacional, 4745 457 S Mamede do Coronado, Portugal
    Drug Metab Dispos 34:1856-62. 2006
    ..available recombinant UGT enzymes studied (UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B15), only UGT1A9 exhibited high nebicapone glucuronosyltransferase specific activity (24.3 +/- 1...
  73. doi Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling
    Sarah Chouinard
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Steroid Biochem Mol Biol 109:247-53. 2008
    ..UGT2B7 is expressed in the liver and skin whereas UGT2B15 and B17 were found in the liver, prostate and skin...
  74. doi Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate
    Olivier Barbier
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center, Laval University, Quebec, Canada
    Best Pract Res Clin Endocrinol Metab 22:259-70. 2008
    ..revealed that three UGT2B enzymes are mainly responsible for DHT, ADT and 3alpha-DIOL glucuronidation: UGT2B7, UGT2B15 and UGT2B17...
  75. ncbi 4-Hydroxy-3-methoxymethamphetamine glucuronide as a phase II metabolite of 3,4-methylenedioxymethamphetamine: enzyme-assisted synthesis and involvement of human hepatic uridine 5'-diphosphate-glucuronosyltransferase 2B15 in the glucuronidation
    Takuji Shoda
    National Institute of Health Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 57:472-5. 2009
    ..Among 12 isoforms of human recombinant UGT expressed in insect cells, UGT2B15 was the only isoform that showed adequate enzymatic activity in catalyzing HMMA glucuronidation with K(m) and V(..
  76. doi Dabigatran acylglucuronide, the major human metabolite of dabigatran: in vitro formation, stability, and pharmacological activity
    Thomas Ebner
    Department of Drug Metabolism and Pharmacokinetics, Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
    Drug Metab Dispos 38:1567-75. 2010
    ..Three UDP-glucuronosyltransferases (UGTs), namely, UGT1A9, UGT2B7, and UGT2B15, exhibited glucuronidation of dabigatran...
  77. pmc The impact of common genetic variations in genes of the sex hormone metabolic pathways on steroid hormone levels and prostate cancer aggressiveness
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
    Cancer Prev Res (Phila) 4:2044-50. 2011
    ..005), UGT2B15 (rs2045100; P = 0.007), and HSD17B12 (rs7932905; P = 0.008)...
  78. doi Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin
    Abu J M Sadeque
    Department of Drug Metabolism and Pharmacokinetics, Arena Pharmaceuticals, Inc, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA
    Drug Metab Dispos 40:772-8. 2012
    ..UGT enzymes, lorcaserin N-carbamoyl glucuronidation was predominantly catalyzed by three UGT2Bs (UGT2B7, UGT2B15, and UGT2B17), whereas two UGT1As (UGT1A6 and UGT1A9) played a minor role...
  79. pmc Protein kinase Cα and Src kinase support human prostate-distributed dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 activity
    Sunit K Chakraborty
    Section on Genetic Disorders of Drug Metabolism, Program on Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 287:24387-96. 2012
    ....
  80. doi Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells
    Nobumitsu Hanioka
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Chemosphere 89:526-9. 2012
    ..the mRNAs of four UGT1As (UGT1A1, UGT1A3, UGT1A4 and UGT1A9) and seven UGT2Bs (UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, UGT2B17 and UGT2B28) are expressed in HepG2 cells...
  81. pmc A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation
    Andrea D Coviello
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002805. 2012
    ..3, p = 1.3 × 10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p = 2.7 × 10(-08)), and UGT2B15 (rs293428, 4q13.2, p = 5.5 × 10(-06))...
  82. doi Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats
    Huihui Liu
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Drug Metab Dispos 40:2109-18. 2012
    ..The diabetic status induced increased UDP-glucuronosyltransferase (UGT) 1A3, UGT1A8, UGT2B8, and sulfotransferase (SULT) 1A1 mRNA levels and decreased catechol-O-methyltransferase (COMT), UGT2B6, UGT2B12, ..
  83. doi The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent
    Frances Stringer
    Takeda Pharmaceutical Company, 1 1, Doshomachi 4 Chome, Chuo Ku, Osaka 540 8645, Japan
    Eur J Clin Pharmacol 69:423-30. 2013
    ..The aim of this analysis was to explore the influence of genetic polymorphism in UGT on the pharmacokinetics of sipoglitazar...
  84. doi The glucuronidation of R- and S-lorazepam: human liver microsomal kinetics, UDP-glucuronosyltransferase enzyme selectivity, and inhibition by drugs
    Verawan Uchaipichat
    Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, South Australia, Australia
    Drug Metab Dispos 41:1273-84. 2013
    ..Based on in vitro clearances and consideration of available in vivo and in vitro data, UGT2B15 is likely to play an important role in the glucuronidation of R- and S-lorazepam...
  85. pmc Prognostic significance of ESR1 amplification and ESR1 PvuII, CYP2C19*2, UGT2B15*2 polymorphisms in breast cancer patients
    Aleksandra Markiewicz
    Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    PLoS ONE 8:e72219. 2013
    ..Additionally, ESR1 PvuII, CYP2C19*2 and UGT2B15*2 polymorphisms were analyzed in the tamoxifen-treated subgroup of patients.
  86. pmc Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure
    Michael H Court
    Pharmacogenomics Laboratory, and Department of veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington M H C Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York I P Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts S H, D J G Program in Pharmacology and Experimental Therapeutics, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts M V, D J G and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas W M L
    Drug Metab Dispos 42:28-32. 2014
    ..evaluated included those in genes encoding putative acetaminophen-metabolizing enzymes (UGT1A1, UGT1A6, UGT1A9, UGT2B15, SULT1A1, CYP2E1, and CYP3A5) as well as CD44 and BHMT1...
  87. pmc A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
    Zhong Ze Fang
    First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China
    J Lipid Res 54:3334-44. 2013
    ..with following orders of potency: UGT1A4 > UGT2B7 > UGT1A3 > UGT1A1 ∼ UGT1A7 ∼ UGT1A10 ∼ UGT2B15. In conclusion, these studies suggest that disrupted homeostasis of BAs, notably taurolithocholic acid, found in ..
  88. pmc Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study
    Adriana C Vidal
    Department of Biology and Cancer Research Program, JLC Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    BMC Cancer 13:556. 2013
    We have previously shown that a functional polymorphism of the UGT2B15 gene (rs1902023) was associated with increased risk of prostate cancer (PC)...
  89. pmc Biotransformation of bisphenol AF to its major glucuronide metabolite reduces estrogenic activity
    Ming Li
    Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing, China
    PLoS ONE 8:e83170. 2013
    ..human recombinant UDP-glucuronosyltransferases (UGTs) including UGT1A1, UGT1A3, UGT1A8, UGT1A9, UGT2B4, UGT2B7, UGT2B15 and UGT2B17, among which UGT2B7 showed the highest efficiency of glucuronidation...
  90. ncbi Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase
    B L Coffman
    Department of Pharmacology, University of Iowa, Iowa City 52242
    Arch Biochem Biophys 281:170-5. 1990
    ..sequence in the deduced amino acid sequence of a cDNA obtained from a human liver library in lambda gt11 (HLUG4)...
  91. ncbi Isolation and purification of two human liver UDP-glucuronosyltransferases
    Y M Irshaid
    Mol Pharmacol 31:27-34. 1987
    ..In general, high concentrations of phosphatidylcholine were required for reconstitution of maximal glucuronidation activity. This report documents the existence of multiple UDP-glucuronosyltransferases in human liver...
  92. ncbi Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols
    M D Green
    Department of Pharmacology, University of Iowa, Iowa City 52242, USA
    Arch Biochem Biophys 322:460-8. 1995
    ..In addition to liver, Northern blot analysis demonstrated that UGT2B12 mRNA is present in kidney and testis...
  93. ncbi Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms
    F Chen
    Section on Genetic Disorders of Drug Metabolism, National Institute of Child Health and Human Development
    Biochemistry 32:10648-57. 1993
    ..Alignment shows that this encoded isozyme is 96% identical to an apparent estriol-metabolizing isoform, HLUG4 [Coffman, B. L., et al., (1990) Arch. Biochem. Biophys. 281, 170-175]...
  94. ncbi Expression of transcripts encoding steroid UDP-glucuronosyltransferases in human prostate hyperplastic tissue and the LNCaP cell line
    G Belanger
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Mol Cell Endocrinol 113:165-73. 1995
    ..Among these UGTs, UGT2B7 is specific for estriol and 3,4-catechol estrogens, UGT2B15 glucuronidates 17beta-hydroxy-C19 steroids while UGT2B10 has as yet an undescribed activity...
  95. ncbi Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids
    M Beaulieu
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Laval University, Quebec G1V 4G2, Canada
    J Biol Chem 271:22855-62. 1996
    ..1 kilobases that encode a novel UGT2B enzyme. UGT2B17 is 95% identical with UGT2B15 and 91% identical with UGT2B8...
  96. ncbi Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells
    C Guillemette
    CHUL Research Center, Laval University, Quebec, Canada
    Endocrinology 138:2998-3005. 1997
    ..with DHT and EGF caused a specific decrease of UGT2B17 transcript in LNCaP cells treated; however, the level of UGT2B15 messenger RNA was not affected...
  97. ncbi Differentially expressed genes in androgen-dependent and -independent prostate carcinomas
    G T Chang
    Department of Endocrinology and Reproduction, Erasmus University Rotterdam, The Netherlands
    Cancer Res 57:4075-81. 1997
    ..unknown (JC19 and GC79) and two known genes [B-cell translocation gene 1 and UDP-glucuronosyltransferase 2B15 (UGT2B15)]...
  98. pmc Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus
    C P Strassburg
    Department of Pharmacology and the Cancer Center, University of California, San Diego La Jolla, CA 92093, USA
    Biochem J 338:489-98. 1999
    ..UGT2 expression included UGT2B7, UGT2B10 and UGT2B15, but UGT2B4 mRNA was absent. UGT2 mRNA was present at significantly lower levels than UGT1 transcripts...
  99. ncbi Characterization of UDP-glucuronosyltransferases active on steroid hormones
    D W Hum
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, Quebec, Canada
    J Steroid Biochem Mol Biol 69:413-23. 1999
    ..The results demonstrate a differential regulation between the two highly related isoforms UGT2B15 and UGT2B17, where only the expression of UGT2B17 was affected following treatments of LNCaP cells with androgens,..
  100. ncbi Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method
    A Tchernof
    Molecular Endocrinology Laboratory, CHUQ Research Center, Ste Foy, Quebec, Canada
    Clin Endocrinol (Oxf) 50:637-42. 1999
    ..The objective of the present study was to investigate whether adipose tissue was a site of expression of the androgen metabolizing enzymes UDP-glucuronosyltransferases (UGT) 2B15 and 2B17...
  101. ncbi Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
    C P Strassburg
    Department of Gastroenterology and Hepatology, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 275:36164-71. 2000
    ....

Research Grants24

  1. Beverly H Koller; Fiscal Year: 2014
    ..we believe will generate mouse lines useful for determining the function of the UGT2B genes, and in particular of UGT2B15 and UGT217...
  2. Factors Determining Bisphenol A Disposition in Human Infants
    D Gail McCarver; Fiscal Year: 2013
    ..In adults, BPA is predominantly conjugated with glucuronide;the predominant human enzyme responsible is UGT2B15. This enzyme is known to exhibit a common, functional polymorphism, but its impact on human BPA metabolism is ..
  3. Pharmacogenetics of Tamoxifen and Chemotherapies and Risk of Contralateral Breast
    Jane C Figueiredo; Fiscal Year: 2010
    ..e., CYP2D6, CYP3A5, SULT1A1, UGT2B15) and drugs commonly used in polychemotherapy regimens for breast cancer including: cyclophosphamide (i.e...
  4. Kathleen E Malone; Fiscal Year: 2014
    ..CYP3A4, CYP3A5, but other important phase I and II enzymes include CYP2C9, CYP2C19, CYP2B6, CYP1B1, UGT2B7, UGT2B15, UGT1A4, UGT1A8, and UGT1A10...
  5. Role of UDP-Glucuronosyltransferases in UV-mediated melanomagenesis
    RYAN WILLIAM DELLINGER; Fiscal Year: 2013
    ..This proposal builds on the novel observation that three UGTs (UGT2B7, UGT2B10 and UGT2B15) are normally expressed in human melanocytes and that their expression is lost during melanoma progression...
  6. Modification of tamoxifen effectiveness by gene polymorphisms and other drugs
    Timothy Lash; Fiscal Year: 2009
    ..Polymorphisms in the genes whose enzymes produce (GYP) or remove (SULT1A1 &UGT2B15) the active metabolites modify the metabolites'plasma concentrations...
  7. Acetaminophen Pharmacogenetics
    Michael H Court; Fiscal Year: 2010
    ....
  8. Mechanisms of adverse host responses to antibiotics
    Michael Court; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  9. Epigenetic Markers for Lung Cancer Detection
    Jong Park; Fiscal Year: 2006
    ..The proposed study will generate data that will be the groundwork for larger studies to validate the use of the identified methylation sites to develop markers for early lung cancer diagnosis. ..
  10. Foward Genetic Study of Surface Coat Genes Expression in Trypanosoma Brucei
    Gwo Shu Lee; Fiscal Year: 2008
    ..The success of this study may lead to potential targets for therapeutic designs via intervention of essential processes involved in the switching of VSG gene expression. [unreadable] [unreadable] [unreadable]..
  11. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  12. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..genotype women for the following functional polymorphisms: UGT1A1*28, UGT1A3(W11R), UGT2B4(D458E), UGT2B7(H268Y), UGT2B15(D85Y) and SULT1A1(R213H)...
  13. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  14. TRANSCIPTION OF PROTEIN CODING GENES IN T BRUCE
    Gwo Shu Lee; Fiscal Year: 2001
    ..abstract_text> ..
  15. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  16. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  17. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  18. FLAGELLAR POCKET PROTEINS OF AFRICAN TRYPANOSOMES
    Gwo Shu Lee; Fiscal Year: 2005
    ..This study will reveal unique aspects of host-parasite interaction and may have practical applications for parasite control. ..
  19. Interaction Between Irinotecan and Dietary Flavonoids
    Lalitha Iyer; Fiscal Year: 2004
    ....
  20. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..concentrations, differs by UGT genotypes for the following isozyme polymorphisms: UGTIAI*28, UGT/A6*2, and UGT2B15(D85Y); 2) To measure the effect of feeding specific V&F under controlled dietary conditions on UGT and beta-G ..
  21. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  22. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  23. Elucidation of epoxide hydrolase polymorphisms
    Jong Park; Fiscal Year: 2002
    ....
  24. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..