UCP1

Summary

Gene Symbol: UCP1
Description: uncoupling protein 1
Alias: SLC25A7, UCP, mitochondrial brown fat uncoupling protein 1, solute carrier family 25 member 7, thermogenin, uncoupling protein 1 (mitochondrial, proton carrier)
Species: human

Top Publications

  1. ncbi Inhibition of uncoupling protein expression during lactation: role of leptin
    Xiao Qiu Xiao
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Endocrinology 145:830-8. 2004
  2. ncbi Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine
    Zbigniew K Binienda
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Neurosci Lett 410:62-5. 2006
  3. doi Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria
    Nadeene Parker
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    J Bioenerg Biomembr 41:335-42. 2009
  4. pmc Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    Ying Cheng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 59:17-25. 2010
  5. ncbi Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene
    Jong S Rim
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 277:34589-600. 2002
  6. ncbi The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research
    M del Mar Gonzalez-Barroso
    Centre de Recherches sur l Endocrinologie Moléculaire et le Développement, CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
    Obes Rev 1:61-72. 2000
  7. ncbi Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers
    Valeri Beck
    Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin, Chariteplatz 1, 10117 Berlin, Germany
    FASEB J 21:1137-44. 2007
  8. doi Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat
    Harold S Sacks
    Department of Medicine, College of Medicine, University of Tennessee Health Science Center Memphis, Tennessee 38163, USA
    J Clin Endocrinol Metab 94:3611-5. 2009
  9. ncbi Association between accumulation of visceral fat and the combination of β3 adrenergic receptor Trp64Arg, β2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2
    Katsuhiko Tsunekawa
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Endocr J 58:1079-86. 2011
  10. doi Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes
    Joo Young Lee
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan
    Am J Physiol Cell Physiol 302:C463-72. 2012

Research Grants

  1. NAOMI MIRIAM HAMBURG; Fiscal Year: 2016
  2. Biochemical regulation of mitochondrial uncoupling protein 3
    MONTE ALEXANDER KENASTON; Fiscal Year: 2010
  3. Feng Liu; Fiscal Year: 2016
  4. MOLECULAR GENETICS OF THERMOGENESIS
    MARTIN ELLIOT YOUNG; Fiscal Year: 2013
  5. Muthu Periasamy; Fiscal Year: 2016
  6. Andreas Stahl; Fiscal Year: 2015
  7. Human Brown Adipose Tissue and its Impact on Metabolism
    AARON MARTIN CYPESS; Fiscal Year: 2013
  8. Identifying Novel Targets for Recruitment of Brown Adipocytes
    Olivier Boss; Fiscal Year: 2013
  9. Noninvasive Imaging of UCP1-mediated Brown Fat Thermogenesis
    RICHARD LEO WAHL; Fiscal Year: 2011
  10. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011

Detail Information

Publications294 found, 100 shown here

  1. ncbi Inhibition of uncoupling protein expression during lactation: role of leptin
    Xiao Qiu Xiao
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Endocrinology 145:830-8. 2004
    ..Compared with control rats, mRNA expression of UCP1 and UCP3 in brown adipose tissue (BAT) was dramatically reduced during lactation and fasting...
  2. ncbi Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine
    Zbigniew K Binienda
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Neurosci Lett 410:62-5. 2006
    ..Hypoxic conditions induce uncoupling protein-2 (UCP-2)...
  3. doi Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria
    Nadeene Parker
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    J Bioenerg Biomembr 41:335-42. 2009
    ..BAT can express another mitochondrial anion carrier, UCP1, at concentrations similar to ANT...
  4. pmc Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    Ying Cheng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 59:17-25. 2010
    ..The cellular mechanisms responsible for this loss, however, are unclear. The goal of current study is to investigate possible mechanisms...
  5. ncbi Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene
    Jong S Rim
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 277:34589-600. 2002
    ..against cold exposure in mammals occurs in brown adipose tissue (BAT) through mitochondrial uncoupling protein (UCP1). Expression of the Ucp1 gene is unique in brown adipocytes and is regulated tightly...
  6. ncbi The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research
    M del Mar Gonzalez-Barroso
    Centre de Recherches sur l Endocrinologie Moléculaire et le Développement, CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
    Obes Rev 1:61-72. 2000
    ..This review summarizes data supporting the existence of brown adipocytes and the role of UCP1 in energy dissipation in adult humans...
  7. ncbi Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers
    Valeri Beck
    Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin, Chariteplatz 1, 10117 Berlin, Germany
    FASEB J 21:1137-44. 2007
    Uncoupling proteins 1 (UCP1) and 2 (UCP2) belong to the family of mitochondrial anion transporters and share 59% sequence identity with each other...
  8. doi Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat
    Harold S Sacks
    Department of Medicine, College of Medicine, University of Tennessee Health Science Center Memphis, Tennessee 38163, USA
    J Clin Endocrinol Metab 94:3611-5. 2009
    Uncoupling protein-1 (UCP-1) is the inner mitochondrial membrane protein that is a specific marker for and mediator of nonshivering thermogenesis in brown adipocytes.
  9. ncbi Association between accumulation of visceral fat and the combination of β3 adrenergic receptor Trp64Arg, β2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2
    Katsuhiko Tsunekawa
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Endocr J 58:1079-86. 2011
    2 and β3 adrenergic receptors (β2AR, β3AR) and uncoupling protein 1 (UCP1) have been considered as candidate genes for obesity...
  10. doi Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes
    Joo Young Lee
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan
    Am J Physiol Cell Physiol 302:C463-72. 2012
    Uncoupling protein (UCP)-1 expressed in brown adipose tissue plays an important role in thermogenesis...
  11. doi Supplementation of Korean fermented soy paste doenjang reduces visceral fat in overweight subjects with mutant uncoupling protein-1 allele
    Myoungsook Lee
    Department of Food and Nutrition, Research Institute of Obesity Sciences, Sungshin Women s University, Seoul, South Korea
    Nutr Res 32:8-14. 2012
    ..is different between the mutant and the wild-type alleles of a polymorphism upstream of the uncoupling protein-1 (UCP-1) gene in overweight subjects...
  12. pmc The contribution of FTO and UCP-1 SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals
    Adauto V Ramos
    Department of Surgery, School of Medicine, Universidade Federal de Minas Gerais, Av, Alfredo Balena 190, Belo Horizonte, 30130 100, Brazil
    BMC Med Genet 13:101. 2012
    ..Sequence variants in two candidate genes, FTO and UCP-1, have been reported to be overrepresented in obese Caucasian population...
  13. doi β₁-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β₃-adrenergic receptor-knockout mice via nonshivering thermogenesis
    Charlotte L Mattsson
    Department of Physiology, The Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 301:E1108-18. 2011
    ..adipocytes, activation of either β(1)-adrenergic receptors or β(3)-adrenergic receptors was able to increase UCP1 mRNA and protein levels...
  14. ncbi Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes
    Gottfried Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Diabetes Care 29:89-94. 2006
    We studied the association between polymorphisms in the UCP genes and diabetes complications in patients with type 1 diabetes.
  15. ncbi Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance
    A Hammarstedt
    The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Biochem Biophys Res Commun 301:578-82. 2003
    ..receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive ..
  16. ncbi DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
    J M Oppert
    Physical Activity Sciences Laboratory, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 18:526-31. 1994
    The objective of this study was to identify DNA sequence variation in the UCP gene and to investigate its relationship with some obesity phenotypes...
  17. ncbi Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
    K Clement
    Department de Nutrition, Hotel Dieu, Paris, France
    Int J Obes Relat Metab Disord 20:1062-6. 1996
    ....
  18. ncbi Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
    C Fleury
    CNRS CEREMOD, Meudon, France
    Nat Genet 15:269-72. 1997
    A mitochondrial protein called uncoupling protein (UCP1) plays an important role in generating heat and burning calories by creating a pathway that allows dissipation of the proton electrochemical gradient across the inner mitochondrial ..
  19. ncbi Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity
    S A Urhammer
    Steno Diabetes Center, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:4069-74. 1997
    Our objective was to investigate whether genetic variants of the uncoupling protein 1 (UCP1) gene are associated with juvenile-onset obesity or alterations in weight gain and insulin sensitivity in young healthy Caucasians...
  20. pmc The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    D Ricquier
    Centre de Recherche sur l Endocrinologie Moléculaire et le Développement CEREMOD, Centre National de la recherche Scientifique CNRS Unit 9078, 9 rue Jules Hetzel, 92190 Meudon, France
    Biochem J 345:161-79. 2000
    ..The brown adipose tissue (BAT) UCP1 has a marked and strongly regulated uncoupling activity, essential to the maintenance of body temperature in small ..
  21. ncbi A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus
    H Mori
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Diabetologia 44:373-6. 2001
    ..We screened the human UCP1 gene (UCP1) for polymorphisms associated with susceptibility to Type II diabetes.
  22. ncbi Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity
    N Shihara
    The Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Int J Obes Relat Metab Disord 25:761-6. 2001
    To investigate the association of the promoter region -3826 A to G polymorphism of the uncoupling protein 1 (UCP1) gene with autonomic nervous system (ANS) activity and the interaction of the polymorphism with the Trp64Arg polymorphism of ..
  23. ncbi Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland
    B Kiec-Wilk
    Department of Clinical Biochemistry, Medical College, Jagiellonian University, Out patient Clinic of Obesity and Lipid Disorders, Krakow, Poland
    J Physiol Pharmacol 53:477-90. 2002
    ..One hundred and eighteen overweight /obese patients participated in the study. The UCP1 polymorphism was determined by RFLP...
  24. ncbi Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio
    Stefan Martin Herrmann
    Department of Clinical Pharmacology, Benjamin Franklin Medical Center, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Mol Med (Berl) 81:327-32. 2003
    ..This study investigated whether genetic variants in the genes encoding UCP-1 and UCP-3 are associated with different obesity-related phenotypes in 162 whites with a wide range of body mass ..
  25. ncbi The -3826 A-->G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys
    Narumi Nagai
    Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606 8501, Japan
    J Clin Endocrinol Metab 88:5661-7. 2003
    This study investigated whether the -3826 A-->G nucleotide variant of the uncoupling protein-1 (UCP1) gene is correlated with postprandial thermogenesis after a high fat meal in children...
  26. ncbi The effects of uncoupling protein-1 genotype on lipoprotein cholesterol level in Korean obese subjects
    Hyun Hee Oh
    Medical R and D Department, Korea Institute of Oriental Medicine, Taejon, South Korea
    Metabolism 53:1054-9. 2004
    Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders...
  27. ncbi The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish population
    Joana Maria Ramis
    Department de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mollrca, Spain
    Metabolism 53:1411-6. 2004
    ..variations in leptin levels according to the beta(3)-adrenoceptor (beta(3)-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826A-->G polymorphisms, given the regulatory role of catecholamines through the beta(3)-AR in leptin ..
  28. ncbi Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes
    Keiko Fukuyama
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 339:1212-6. 2006
    The -112A>C polymorphism (rs10011540) of the gene for uncoupling protein 1 (UCP1) has been associated with type 2 diabetes mellitus in Japanese individuals...
  29. ncbi A/G heterozygote of the A-3826G polymorphism in the UCP-1 gene has higher BMI than A/A and G/G homozygote in young Japanese males
    Takuro Nakano
    Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School
    J Med Invest 53:218-22. 2006
    b>UCP-1 is suggested to have important roles for thermogenesis and energy expenditure...
  30. ncbi The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population
    D Sramkova
    Institute of Endocrinology, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 115:303-7. 2007
    ..The brown fat specific uncoupling protein 1 (UCP1) mRNA was detected in intraperitoneal and extraperitoneal adipose tissue in adult humans...
  31. ncbi Relationship between A-3826G polymorphism in the promoter of the uncoupling protein-1 gene and high-density lipoprotein cholesterol in Japanese individuals: a cross-sectional study
    Kazuhiko Kotani
    Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan
    Arch Med Res 39:142-6. 2008
    A-3826G polymorphism within the promoter region of the uncoupling protein-1 (UCP-1) gene is possibly involved in the pathophysiology of obesity and metabolic disorders...
  32. doi UCP1 genetic polymorphism (-3826 A/G) diminishes resting energy expenditure and thermoregulatory sympathetic nervous system activity in young females
    N Nagai
    Laboratory of Nutritional Physiology, Graduate School of Human Science and Environment, University of Hyogo, Hyogo, Japan
    Int J Obes (Lond) 35:1050-5. 2011
    Recent findings regarding the existence of functional brown adipose tissue (BAT) in adult humans suggest a physiological role of BAT and uncoupling protein 1 (UCP1)-linked thermogenesis in energy balance.
  33. doi Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    Exp Gerontol 46:897-904. 2011
    The brown fat specific UnCoupling Protein 1 (UCP1) is involved in thermogenesis, a process by which energy is dissipated as heat in response to cold stress and excess of caloric intake...
  34. ncbi Sex-dependent effects of the UCP1 -3826 A/G polymorphism on obesity and blood pressure
    Meenal Dhall
    Obesity Research Unit, Physiological Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi
    Ethn Dis 22:181-4. 2012
    ..To ascertain the association of -3826 A/G polymorphism with blood pressure and different obesity markers...
  35. doi The presence of at least three alleles of the ADRB3 Trp64Arg (C/T) and UCP1 -3826A/G polymorphisms is associated with protection to overweight/obesity and with higher high-density lipoprotein cholesterol levels in Caucasian-Brazilian patients with type 2
    Letícia A Brondani
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil
    Metab Syndr Relat Disord 12:16-24. 2014
    We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) ..
  36. ncbi The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects
    Hyoung Doo Shin
    SNP Genetics, Complex B, WooLim Lion s Valley, 371 28, Gasan Dong, Geumcheon gu, Seoul 153 803, Republic of Korea
    Biochem Biophys Res Commun 335:624-30. 2005
    Three SNPs of UCP-1 including A-3826G, A-1766G, and Ala64Thr (G+1068A) were genotyped among 453 overweight Korean female subjects recruited from an obesity clinic. Four common haplotypes with frequency greater than 0...
  37. doi Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women
    Narumi Nagai
    Department of Food Science and Nutrition, School of Human Science and Environment, University of Hyogo, Hyogo 670 0092, Japan
    Nutr Res 31:255-61. 2011
    Uncoupling protein 1 (UCP1) plays an important role in thermogenesis in brown adipose tissue...
  38. ncbi Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects
    K Sivenius
    Department of Clinical Nutrition, University of Kuopio, Finland
    Int J Obes Relat Metab Disord 24:514-9. 2000
    ..of the beta3-adrenergic receptor (beta3AR) gene and the (-3826) A-->G polymorphism of the uncoupling protein 1 (UCP1) gene on body weight change in type 2 diabetic and non-diabetic control subjects during a 10y follow-up study.
  39. ncbi Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young D
    S A Urhammer
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    J Clin Endocrinol Metab 85:3151-4. 2000
    ..of the beta3-adrenergic receptor (BAR) gene and the -3826 A-->G nucleotide variant of the uncoupling protein-1 (UCP1) gene are associated with obesity, insulin resistance, or alterations in size at birth in a Danish study population ..
  40. ncbi Genetic factors as predictors of weight gain in young adult Dutch men and women
    C T M van Rossum
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Int J Obes Relat Metab Disord 26:517-28. 2002
    ..Polymorphisms in these genes may contribute to weight gain through effects on energy intake, energy expenditure or adipogenesis...
  41. ncbi Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy
    Eero Lindholm
    Department of Endocrinology, University Hospital MAS, SE 205 02 Malmo, Sweden
    J Diabetes Complications 18:103-7. 2004
    ..To test this hypothesis we searched for association between the A-->G (-3862) variant in UCP1, the insertion/deletion (I/D) polymorphism in exon 8 in UCP2, and the C-->T (-55) polymorphism in UCP3 and ..
  42. ncbi Brown fat UCP1 is specifically expressed in uterine longitudinal smooth muscle cells
    M Nibbelink
    Unite Mixte de Recherche 5018 CNRS, IFR31 Rangueil University Hospital, F 31403 Toulouse Cedex 4, France
    J Biol Chem 276:47291-5. 2001
    Until now, uncoupling protein 1 (UCP1) was considered as unique to brown adipocytes. It supports a highly regulated uncoupling of oxidative phosphorylation that is associated with diet as well as with non-shivering thermogenesis...
  43. ncbi Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention Study
    T Salopuro
    Clin Genet 66:365-7. 2004
  44. ncbi Long photophase is not a sufficient stimulus to reduce thermogenic capacity in winter-acclimatized short-tailed field voles (Microtus agrestis) during long-term cold acclimation
    R M McDevitt
    Department of Zoology, University of Aberdeen, Scotland, UK
    J Comp Physiol B 164:159-64. 1994
    ..tissue, the ratio of white adipose tissue to brown adipose tissue, the concentration of the uncoupling protein (thermogenin) in whole depots (micrograms) and in mitochondrial mass (micrograms...
  45. ncbi Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
    T Teruel
    Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University, 28040, Madrid, Spain
    Diabetologia 48:1180-8. 2005
    ..2) hormone-sensitive lipase (hsl), which mobilises fatty acids from stored triglycerides; (3) fatty acid synthase (fas), which regulates de novo lipogenesis; and (4) the uncoupling proteins (ucp) 1 and 3, which control thermogenesis.
  46. ncbi Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines
    E M Rohlfs
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 270:10723-32. 1995
    ..Expression of brown fat-specific mitochondrial uncoupling protein (Ucp) was stimulated by beta-adrenergic agonists in two of the four cell lines...
  47. ncbi Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression
    L J Kelly
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 139:4920-7. 1998
    ..Recently, three distinct uncoupling protein isoforms, UCP-1, UCP-2, and UCP-3, have also been identified and implicated as mediators of thermogenesis...
  48. ncbi Brown adipose tissue development and metabolism in ruminants
    S B Smith
    Department of Animal Science, Texas A and M University, College Station 77843, USA
    J Anim Sci 82:942-54. 2004
    ..Brahman BAT contained two-to-three times as many total beta-receptors as Angus BAT. The mitochondrial UCP1:28S rRNA ratio was greater in Brahman BAT than in BAT from Angus calves...
  49. ncbi UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency
    J Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1504:82-106. 2001
    The uniqueness of UCP1 (as compared to UCP2/UCP3) is evident from expression analysis and ablation studies...
  50. ncbi Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation
    Ken ichi Inokuma
    Dept of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Am J Physiol Endocrinol Metab 290:E1014-21. 2006
    Mitochondrial uncoupling protein-1 (UCP1) has been thought to be a key molecule for thermogenesis during cold exposure and spontaneous hyperphagia and thereby in the autonomic regulation of energy expenditure and adiposity...
  51. pmc Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice
    Carola W Meyer
    Dept of Animal Physiology, Faculty of Biology, Philipps Universitat, Karl von Frisch Strasse 8, 35032 Marburg, Germany
    Am J Physiol Regul Integr Comp Physiol 299:R1396-406. 2010
    ..WA; 27°C), moderate cold (MCA; 18°C), or cold acclimated (CA; 5°C) wild-type and uncoupling-protein 1 knockout (UCP1-KO) mice...
  52. doi A CD study of uncoupling protein-1 and its transmembrane and matrix-loop domains
    Masoud Jelokhani-Niaraki
    Department of Chemistry, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Biochem J 411:593-603. 2008
    Conformations of the prototypic UCP-1 (uncoupling protein-1) and its TM (transmembrane) and ML (matrix-loop) domains were studied by CD spectroscopy...
  53. ncbi Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice
    A Melnyk
    Department of Biochemistry, University of Ottawa, Ontario, Canada
    Am J Physiol 274:R1131-5. 1998
    ..ability of control and transgenic brown adipose tissue (BAT)-ablated uncoupling protein diphtheria toxin A chain (UCP-DTA) mice to adjust food intake in relation to changes in environmental temperature and to assess the involvement ..
  54. ncbi GG-genotype in the promotor region of uncoupling-protein-1 gene is associated with lower level of dehydroepiandrosterone in type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Germany
    Exp Clin Endocrinol Diabetes 109:102-6. 2001
    The A-->G (-3826) point mutation within the distal region of the uncoupling-protein-1 (UCP-1) promoter is possibly involved in the development of obesity, diabetes and related disorders...
  55. pmc Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively
    Irina G Shabalina
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem J 399:405-14. 2006
    In brown-fat mitochondria, fatty acids induce thermogenic uncoupling through activation of UCP1 (uncoupling protein 1). However, even in brown-fat mitochondria from UCP1-/- mice, fatty-acid-induced uncoupling exists...
  56. ncbi Cold acclimation-associated changes in brown adipose tissue do not necessarily indicate an increase of nonshivering thermogenesis in C57BL/6J mice
    M I Talan
    Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Physiol Behav 60:1285-9. 1996
    ..In a separate group of mice, the total amount and concentration of mitochondrial uncoupling protein, thermogenin (UCP), in IBAT was measured immediately after completion of the cold-acclimation procedure...
  57. ncbi Differentiation-dependent expression of cathepsin D and importance of lysosomal proteolysis in the degradation of UCP1 in brown adipocytes
    Banafsheh Moazed
    University of Saskatchewan, College of Medicine, Department of Physiology, Saskatoon, Canada
    Can J Physiol Pharmacol 80:515-25. 2002
    ..In contrast, exposure of the cells to NE for 7 days increased their UCP1 content by more than twofold, which returned to basal levels within 48 h of withholding NE...
  58. ncbi [Effects of palmitic acid on activity of uncoupling proteins and proton leak in in vitro cerebral mitochondria from the rats exposed to simulated high altitude hypoxia]
    Yu Xu
    Department of Pathophysiology and Altitude Physiology, The Third Military Medical University, Chongqing 400038, China
    Sheng Li Xue Bao 60:59-64. 2008
    ..The brain mitochondria were isolated by centrifugation. UCP content and activity were detected by [(3)H]-GTP binding method...
  59. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
    ..humans, brown adipose tissue helps regulate energy expenditure by thermogenesis mediated by the expression of uncoupling protein 1 (UCP1), but brown adipose tissue has been considered to have no physiologic relevance in adult humans.
  60. doi The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes
    Raquel Martinez de Mena
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Endocrinology 151:5074-83. 2010
    Brown adipose tissue (BAT) thermogenesis increases when uncoupling protein-1 (UCP1) is activated adrenergically and requires T3. In humans, UCP1 activation in BAT seems involved in body weight maintenance...
  61. ncbi Uncoupling proteins 2 and 3 with age: regulation by fasting and beta3-adrenergic agonist treatment
    P J Scarpace
    Geriatric Research, Education and Clinical Center, Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
    J Gerontol A Biol Sci Med Sci 55:B588-92. 2000
    ..In addition to uncoupling protein 1 (UCP1), UCP3 and possibly UCP2 may have a role in energy homeostasis in BAT...
  62. doi Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice
    R Oelkrug
    Department of Animal Physiology, Faculty of Biology, Philipps Universitat, Karl von Frisch Strasse 8, 35043 Marburg, Germany
    J Comp Physiol B 181:137-45. 2011
    In eutherian mammals, uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis from brown adipose tissue (BAT) provides a mechanism through which arousal from torpor and hibernation is facilitated...
  63. ncbi Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii
    W Jarmuszkiewicz
    Department of Bioenergetics, Adam Mickiewicz University, Fredry 10, 61 701 Poznan, Poland
    J Biol Chem 274:23198-202. 1999
    An uncoupling protein (UCP) has been identified in mitochondria from Acanthamoeba castellanii, a nonphotosynthetic soil amoeboid protozoon that, in molecular phylogenesis, appears on a branch basal to the divergence points of plants, ..
  64. ncbi Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth
    S Brun
    Department of Biochemistry and Molecular Biology, University of Barcelona, Spain
    Diabetes 48:1217-22. 1999
    The recently identified uncoupling protein-3 (UCP-3) gene, predicted to encode a new member of the family of uncoupling proteins, is preferentially expressed in skeletal muscle and has been related to phenotypes of obesity and type 2 ..
  65. pmc Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta
    M Carmen Carmona
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Catalunya, Spain
    Biochem J 389:47-56. 2005
    C/EBPbeta (CCAAT/enhancer-binding protein beta) is a transcriptional regulator of the UCP1 (uncoupling protein-1) gene, the specific marker gene of brown adipocytes that is responsible for their thermogenic capacity...
  66. ncbi UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/- mice
    Jozef Ukropec
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 281:31894-908. 2006
    Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of thermogenic mechanisms that can be activated to reduce a positive energy balance is largely unknown...
  67. ncbi Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain
    Martin Jastroch
    Animal Physiology, Department of Biology, Philipps University Marburg, Karl von Frisch Str 8, Marburg, 35032, Germany
    J Comp Physiol B 177:743-52. 2007
    Mammalian uncoupling protein 1 (UCP1) mediates nonshivering thermogenesis in brown adipose tissue...
  68. ncbi The role of leptin in the transition from fetus to neonate
    A Mostyn
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham, UK
    Proc Nutr Soc 60:187-94. 2001
    ..This factor is particularly important in lambs in which levels of UCP1 peak at birth, concomitant with a rapid decline in plasma leptin levels...
  69. ncbi The suitability of a faecal suspension of sheep as inocula for the estimation of utilizable crude protein of feeds by in vitro incubation
    G Y Zhao
    College of Animal Science and Technology, China Agricultural University, Beijing, PR China
    Arch Anim Nutr 58:137-48. 2004
    ..to study the suitability of using a faecal suspension of sheep for the estimation of the utilizable crude protein (uCP) of feeds for sheep by an in vitro incubation...
  70. ncbi Modulation of uncoupling protein 2 and uncoupling protein 3: regulation by denervation, leptin and retinoic acid treatment
    P J Scarpace
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
    J Endocrinol 164:331-7. 2000
    We recently reported that the leptin-induced increase in uncoupling protein 1 (UCP1) mRNA in brown adipose tissue (BAT) is prevented by the denervation of BAT. We also reported that retinoic acid (RA) increases UCP1 mRNA in BAT...
  71. ncbi Urinary C-peptide excretion in free-living healthy children is related to dietary carbohydrate intake but not to the dietary glycemic index
    Anette E Buyken
    Research Institute of Child Nutrition, Dortmund, Germany
    J Nutr 136:1828-33. 2006
    This study first examined whether urinary C-peptide (UCP), stored at -20 degrees C, remains stable over the long term, and second, whether the dietary glycemic index (GI) and the glycemic load (GL: GI x g carbohydrates) are related to ..
  72. pmc Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation
    Agatha Schluter
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Facultat de Biologia, Avda Diagonal 645, Barcelona 08028, Spain
    Biochem J 362:61-9. 2002
    ..Phytanic acid increased uncoupling protein-1 (UCP1) mRNA expression in brown adipocytes differentiated in culture...
  73. ncbi Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    J Biol Chem 277:47129-35. 2002
    Superoxide activates nucleotide-sensitive mitochondrial proton transport through the uncoupling proteins UCP1, UCP2, and UCP3 (Echtay, K. S., et al. (2002) Nature 415, 1482-1486)...
  74. ncbi White adipose tissue contributes to UCP1-independent thermogenesis
    J G Granneman
    Center for Integrative Metabolic and Endocrine Research, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Endocrinol Metab 285:E1230-6. 2003
    ..In contrast, beta3-AR activation did not increase BAT blood flow in mice lacking UCP1 (UCP1 KO)...
  75. ncbi Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids
    Irina G Shabalina
    Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 279:38236-48. 2004
    Elucidation of the regulation of uncoupling protein 1 (UCP1) activity in its native environment, i.e...
  76. doi Large litter size increases maternal energy intake but has no effect on UCP1 content and serum-leptin concentrations in lactating Brandt's voles (Lasiopodomys brandtii)
    Xue Ying Zhang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Datun Lu, Chaoyang, Beijing 100101, People s Republic of China
    J Comp Physiol B 178:637-45. 2008
    ..We measured maternal energy intake, uncoupling protein 1 (UCP1) content in brown adipose tissue (BAT), serum-leptin concentration, and litter growth in lactating Brandt's voles (..
  77. ncbi Effect of selective beta-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes
    P Puigserver
    Dept de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Mol Cell Endocrinol 117:7-16. 1996
    ..adipocytes, the present study was undertaken to determine the relative importance of these in the induction of UCP synthesis in mouse BAT precursor cells in primary culture...
  78. ncbi Chloride channel properties of the uncoupling protein from brown adipose tissue mitochondria: a patch-clamp study
    S G Huang
    Institute of Physical Biochemistry, University of Munich, Germany
    Biochemistry 35:16806-14. 1996
    The uncoupling protein (UCP) from brown adipose tissue mitochondria possesses H+ and Cl- transport activities [reviewed in Klingenberg, M. (1990) Trends Biochem. Sci. 15, 108-112]...
  79. ncbi Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map
    H Yoshitomi
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 215:77-84. 1998
    Brown adipose tissue and skeletal muscle are important sites of non-shivering thermogenesis. It has been known that UCP1 and UCP2 function as the main effector of the thermogenesis: the former is expressed exclusively in brown adipose ..
  80. ncbi Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice
    S Monemdjou
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    Am J Physiol Endocrinol Metab 279:E941-6. 2000
    Mice having targeted inactivation of uncoupling protein 1 (UCP1) are cold sensitive but not obese (Enerbäck S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper M-E, and Kozak LP. Nature 387: 90-94, 1997)...
  81. ncbi Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice
    W E Hofmann
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 276:12460-5. 2001
    An interaction between free fatty acids and UCP1 (uncoupling protein-1) leading to de-energization of mitochondria was assumed to be a key event for triggering heat production in brown fat. Recently, Matthias et al...
  82. ncbi Analysis of inhibition by H89 of UCP1 gene expression and thermogenesis indicates protein kinase A mediation of beta(3)-adrenergic signalling rather than beta(3)-adrenoceptor antagonism by H89
    J M Fredriksson
    Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, SE 106 91, Stockholm, Sweden
    Biochim Biophys Acta 1538:206-17. 2001
    ..40 microM), and in cultured cells, adrenergically stimulated expression of the uncoupling protein-1 (UCP1) gene was abolished by H89 (full inhibition with 50 microM)...
  83. ncbi Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice
    J Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem Soc Trans 29:756-63. 2001
    ..UCP1 (thermogenin) thus remains the only protein the activity of which can be recruited for the purpose of facultative ..
  84. ncbi Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells
    Carine Duval
    Unité Mixte recherche UMR INSERM U466, Institut Federatif de Recherche IFR 31, Toulouse, France
    Biochem Cell Biol 80:757-64. 2002
    Uncoupling protein 2 (UCP-2) belongs to the mitochondrial anion carrier family. It is ubiquitously expressed but is most abdundant in the reticuloendothelial system...
  85. ncbi Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis
    Martin Jastroch
    Department of Animal Physiology, Biology Faculty, Philipps University Marburg, Germany
    Physiol Genomics 22:150-6. 2005
    Uncoupling proteins (UCPs) increase proton leakage across the inner mitochondrial membrane. Thereby, UCP1 in brown adipose tissue dissipates proton motive force as heat...
  86. ncbi The molecular and biochemical basis of nonshivering thermogenesis in an African endemic mammal, Elephantulus myurus
    Nomakwezi Mzilikazi
    Dept of Zoology, Nelson Mandela Metropolitan University, P O Box 77000, Port Elizabeth, 6031, South Africa
    Am J Physiol Regul Integr Comp Physiol 293:R2120-7. 2007
    Uncoupling protein 1 (UCP1) mediated nonshivering thermogenesis (NST) in brown adipose tissue (BAT) is an important avenue of thermoregulatory heat production in many mammalian species...
  87. ncbi Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals
    Shigeru Saito
    Laboratory of Bioscience, Faculty of Engineering, Iwate University, Morioka, Japan
    Gene 408:37-44. 2008
    ..The evolutionary origin of UCP1 was believed to have been a specific event occurring in eutherian lineages...
  88. pmc Nonshivering thermogenesis protects against defective calcium handling in muscle
    Jan Aydin
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    FASEB J 22:3919-24. 2008
    ..thermogenesis with increased heat production in brown adipose tissue due to activation of uncoupling protein-1 (UCP1)...
  89. pmc Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis
    David A Hughes
    Max Planck Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, Leipzig, Germany
    BMC Evol Biol 9:4. 2009
    Uncoupling protein 1 (UCP1) is a mitochondrial anion carrier, expressed in brown adipose tissue (BAT) of Eutherians...
  90. pmc Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytes
    Angeliki Karamitri
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD
    J Biol Chem 284:20738-52. 2009
    Cold stress in rodents increases the expression of UCP1 and PGC-1alpha in brown and white adipose tissue...
  91. doi Uncoupling protein 1 inhibition by purine nucleotides is under the control of the endogenous ubiquinone redox state
    Aleksandra Swida-Barteczka
    Laboratory of Bioenergetics, Adam Mickiewicz University, Umultowska 89, 61 614 Poznan, Poland
    Biochem J 424:297-306. 2009
    We studied non-esterified fatty acid-induced uncoupling of heterologously expressed rat UCP1 (uncoupling protein 1) in yeast mitochondria, as well as UCP1 in rat BAT (brown adipose tissue) mitochondria...
  92. ncbi [Thyroid hormones, obesity and brown adipose tissue thermogenesis]
    A A Zaninovich
    Centro de Investigaciones de la Glándula Tiroides CONICET, Centro de Medicina Nuclear, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Medicina (B Aires) 61:597-602. 2001
    ..receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1)...
  93. ncbi Characterization of the murine fatty acid transport protein gene and its insulin response sequence
    T Y Hui
    Department of Biochemistry, University of Minnesota, St Paul, Minnesota 55108, USA
    J Biol Chem 273:27420-9. 1998
    ..three other genes important for fatty acid homeostasis, lipoprotein lipase, the mitochondrial uncoupling protein 1 (UCP1) and sterol regulatory element-binding protein 1...
  94. ncbi Tryptophan fluorescence of mitochondrial uncoupling protein
    P Jezek
    Department of Membrane Transport Biophysics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Gen Physiol Biophys 17:157-78. 1998
    Mitochondrial uncoupling protein (UcP) contains two tryptophans buried in transmembrane alpha-helices: Trp-173 at the matrix end of fourth alpha-helix and Trp-280 on the sixth alpha-helix...
  95. ncbi First evidence of uncoupling protein-2 (UCP-2) and -3 (UCP-3) gene expression in piglet skeletal muscle and adipose tissue
    M Damon
    INRA, Station de Recherches Porcines, 35590, Saint Gilles, France
    Gene 246:133-41. 2000
    ..Until now, the presence of UCP1 or other UCP homologs had not been detected in tissues of pig, a species where evidence for the presence of brown ..
  96. ncbi Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content
    J Kerner
    Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol Endocrinol Metab 281:E1054-62. 2001
    ..Consistent with the tighter coupling, there was a 68% reduction in uncoupling protein-3 (UCP-3) abundance in mitochondria from elderly compared with adult rats...
  97. ncbi Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes
    Bibian Garcia
    Unidad de Endocrinologia Molecular, Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, 28029 Madrid, Spain
    Am J Physiol Cell Physiol 282:C105-12. 2002
    ..and bFGF), and vasopressin on brown adipocyte differentiation, we analyzed the expression of uncoupling protein-1 (UCP-1) mRNA...
  98. pmc Expression of uncoupling proteins-1, -2 and -3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor
    C Bing
    Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool L69 3G, UK
    Br J Cancer 86:612-8. 2002
    ....
  99. ncbi Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes
    Almudena Porras
    Departamento de Bioquimica y Biologia Molecular II, Instituto de Bioquimica, Centro Mixto del Consejo Superior de Investigaciones Cientificas y de la Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain
    FEBS Lett 520:58-62. 2002
    ..kinases (ERKs) mediate the inhibitory effect of tumor necrosis factor alpha (TNF-alpha) on uncoupling protein-1 (UCP-1), but not on lipid accumulation...
  100. ncbi Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
    Angel A Zaninovich
    Thyroid Research Laboratory, Nuclear Medicine Center, University Hospital, 1120 Buenos Aires, Argentina
    Am J Physiol Endocrinol Metab 283:E496-502. 2002
    ..cold exposure of hypothyroid rats markedly increased BAT weight, mitochondrial proteins, uncoupling protein (UCP)-1, mRNA for UCP-1, and oxygen consumption to levels similar to those seen in cold-exposed normal rats...
  101. ncbi The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis
    George Wolf
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Nutr Rev 61:387-90. 2003
    ..PPAR(delta) also activates the heat-producing uncoupling enzymes in brown adipose tissue (UCP1 and 3) and muscle (UCP2).

Research Grants66

  1. NAOMI MIRIAM HAMBURG; Fiscal Year: 2016
    ..energy excess creates a vicious cycle of increased ROS that triggers mitochondrial fragmentation and an inadequate UCP-2 response that further increases ROS and impairs endothelial function...
  2. Biochemical regulation of mitochondrial uncoupling protein 3
    MONTE ALEXANDER KENASTON; Fiscal Year: 2010
    ..the various functions performed by these proteins, no other protein has been found to directly interact with any UCP. Recent results of a yeast-two hybrid experiment indicate that the protein delta 2,4, delta 3,5 dienoyl-CoA ..
  3. Feng Liu; Fiscal Year: 2016
    ..and the conversion of BAT to a WAT-like tissue, drastically suppressed the expression of uncoupling protein 1 (UCP1) and energy expenditure, and significantly enhanced high fat diet (HFD)-induced insulin resistance...
  4. MOLECULAR GENETICS OF THERMOGENESIS
    MARTIN ELLIOT YOUNG; Fiscal Year: 2013
    ..We have forced mice, in which the mitochondrial uncoupling protein1 (UCP1) has been ablated, to activate alternative mechanisms of thermogenesis by gradually exposing them to the cold...
  5. Muthu Periasamy; Fiscal Year: 2016
    ..activation of muscle-based NST during cold exposure and determine if SLN can replace/substitute for loss of BAT (UCP1) function in mammals...
  6. Andreas Stahl; Fiscal Year: 2015
    ..Thus, both induction/activation of uncoupling protein 1 (UCP1) and LCFA uptake/activation by BAT are essential to thermogenesis...
  7. Human Brown Adipose Tissue and its Impact on Metabolism
    AARON MARTIN CYPESS; Fiscal Year: 2013
    ..expenditure and thermogenesis through numerous mitochondria and the expression of the unique uncoupling protein 1 (UCP-1)...
  8. Identifying Novel Targets for Recruitment of Brown Adipocytes
    Olivier Boss; Fiscal Year: 2013
    ..Brown adipocytes have an extremely high metabolic rate because they express mitochondrial uncoupling protein-1 (UCP1). This protein dissipates the electrochemical gradient in the mitochondria of brown adipocytes as heat...
  9. Noninvasive Imaging of UCP1-mediated Brown Fat Thermogenesis
    RICHARD LEO WAHL; Fiscal Year: 2011
    ..The uncoupling protein-1 (UCP1), a constituent of the mitochondrial inner membrane, is the key player in BAT thermogenesis that allows an energy-..
  10. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..always small (1-2 mm), had the unilocular appearance of white adipose and did not express the thermogenic marker, UCP1. In addition, skeletal myoblasts expressing PRDM16 formed ectopic depots of adipose tissue after subcutaneous ..
  11. Robert G Roeder; Fiscal Year: 2015
    ..investigate the molecular basis for the dramatic, metabolically favorable phenotype (induction of the thermogenic UCP1 and slow-twitch Type I myofiber genes;increased insulin sensitivity/glucose tolerance and resistance to diet-..
  12. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ....
  13. Antonio C Bianco; Fiscal Year: 2014
    ..from impaired embryonic BAT development, with decreased expression of genes defining BAT identity (Dio2, PGC- 11, UCP1) (12)...
  14. Susan S Smyth; Fiscal Year: 2014
    ..In mice, overexpression of autotaxin reduces UCP1 expression and promotes diet-induced obesity...
  15. Mechanisms by which the protein kinase IKKi regulates energy expenditure
    JONATHAN CARL MOWERS; Fiscal Year: 2012
    ..In mice, adaptive thermogenesis is largely promoted by uncoupling protein-1 (UCP1) in brown adipose tissue, although white adipose tissue may also participate through the regulated expression of ..
  16. Satyanarayana Ande; Fiscal Year: 2015
    ..and Id1-deficiency in mice resulted in enhanced thermogenesis due to induced expression of PGC1[unreadable] and UCP1, critical regulators of thermogenesis...
  17. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..in vivo adipogenesis, newly recruited macrophages in adipose tissues, mitochondria content, uncoupling protein (UCP)1 expression, monocyte migration, and monocyte M1/M2 gene expression. We finally study if PM2...
  18. Imaging Adrenergic Stimulation of Brown Adipose Tissue
    Jogeshwar Mukherjee; Fiscal Year: 2012
    ..of adrenergic system (epinephrine/norepinephrine and [unreadable]3 adrenergic receptor) via the uncoupling protein (UCP) in BAT thermogenesis has been reported...
  19. Hei Sook Sul; Fiscal Year: 2015
    ..In contrast, brown adipose tissue (BAT) uses FA to activate uncoupling protein 1 (UCP1) for non-shivering thermogenesis to dissipate energy as heat...
  20. Hei Sook Sul; Fiscal Year: 2016
    ..Inducing thermogenic genes such as uncoupling protein-1 (UCP1) and promoting BAT development could be therapeutic strategies for obesity...
  21. Noninvasive Measurement of UCP1 in Brown Adipose Tissue
    Joel K Yisraeli; Fiscal Year: 2012
    ..We propose to design and test novel RNA molecules that will sense the presence of UCP1 mRNA, a marker for the presence and activity of BAT...
  22. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..and CREB phosphorylation, leading to an up-regulation of the expressions of PPARgamma coactivator PGC-1 alpha and UCP-1 in brown adipocytes or UCP3 in myocytes...
  23. Role of LRP130 in brown adipocyte determination
    Marcus P Cooper; Fiscal Year: 2010
    ..LRP130 regulates several PGC-1 dependent brown fat markers, including uncoupling protein 1 (Ucp1), which is important for thermogenesis and is a hallmark of brown adipocyte determination...
  24. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..We also found that BDNF immediately increases uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT), suggesting that BDNF induces EE elevation via activation of BAT UCP1...
  25. Ronald B Myers; Fiscal Year: 2015
    ..fat since isolated white adipose tissue from ARRDC3-null mice has increased lipolysis and increased expression of Ucp1 relative to wild-type littermates. This proposal aims to define the mechanisms by which ARRDC3 regulates obesity...
  26. Lipid overload and skeletal muscle energetics.
    Paul J Schaeffer; Fiscal Year: 2010
    ..the time course of the development of obesity, metabolic syndrome and type 2 diabetes in a mouse model (the UCP-dta mouse) that lacks brown adipose tissue, becomes obese and develops insulin resistance...
  27. Edward M Mills; Fiscal Year: 2015
    ..In mammals, brown fat UCP1 is the established mediator of cold-induced thermogenesis...
  28. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..important physiological endpoints of this regulation is the induction of the main thermogenic protein in brown fat, UCP1. Two main hypotheses are proposed...
  29. Robert H Eckel; Fiscal Year: 2014
    ..gene expression in the hypothalamus, marked brown adipose tissue (BAT) hyperplasia/hypertrophy and increased BAT UCP-1 gene expression...
  30. Daret K St Clair; Fiscal Year: 2014
    ..We also found that the level of the mitochondrial uncoupling protein 1 (UCP1) is significantly increased in skin tissues of MnSOD-deficient mice...
  31. Ahmed Bettaieb; Fiscal Year: 2014
    ..activated a brown fat-like gene program, which translated into increased mitochondria biogenesis and expression of UCP1, BMP7, and PRDM16. To further delineate PKM2 metabolic functions we will employ complementary approaches...
  32. Nima Saeidi; Fiscal Year: 2014
    ..To do so, UCP1 knockout mice will be employed and RYGB-induced alterations in the in vivo metabolic rate, WAT and BAT phenotypes ..
  33. Metabolic and Mitochondrial Defects of Islet beta-cells of MODY-3
    Gary Cline; Fiscal Year: 2009
    ..that impaired glycolytic flux, altered mitochondria! metabolism and oxidative phosphorylation, or upregulation of UCP-2 expression may contribute to the reduction in insulin secretion...
  34. Mechanisms of MDMA-induced hyperthermia
    Edward Mills; Fiscal Year: 2009
    ..In mammals, brown fat UCP1 is thought to be the dominant, if not the only significant mediator of thermogenic responses...
  35. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2005
    ..sequalae (p-STAT3 and SOCS-3) and metabolic indices (body temperature, 24h urinary NE activity, oxygen consumption, UCP1 mRNA, and blood leptin, insulin glucose, and corticosterone levels)...
  36. ROLE OF THYROID HORMONE IN BROWN ADIPOSE TISSUE FUNCTION
    Jorge Silva; Fiscal Year: 1991
    ..Brown adipose tissue (BAT) is the main site of facultative thermogenesis in most mammals and Uncoupling Protein (UCP) is the key element for BAT thermogenic function. UCP synthesis is regulated by the SNS and thyroid hormone...
  37. BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTES
    Sheila Collins; Fiscal Year: 2003
    ..The effect of selective beta3AR agonists to stimulate lipolysis in white adipocytes, UCP1 transcription and thermogenesis in brown adipocytes, and the physiological effects of beta3AR-agonists in vivo on ..
  38. Regulation of energy metabolism in the failing heart
    Raymond Russell; Fiscal Year: 2005
    ..flux (citrate synthase and alpha- ketoglutarate dehydrogenase), and oxidative phosphorylation (uncoupling protein (UCP)-2 and UCP-3) the role of AMPK activation in regulating metabolism in the failing heart...
  39. Bruce M Spiegelman; Fiscal Year: 2016
    ..cultured muscle cells and transgenic mice stimulates the secretion of an activity that can drive the expression of UCP1 and other genes of the brown fat program in white adipose cells...
  40. MICHAEL L CAMILLERI; Fiscal Year: 2014
    ..to explore effects of other genes that are associated with obesity in epidemiological studies (uncoupling proteins [UCP], and FTO, and type II DM [TCF7L2]) on peripheral determinants of satiation and satiety though validated ..
  41. Uncoupling Protein Polymorphisms and Cardiometabolic Responses to Beta-Blockers
    Amber L Beitelshees; Fiscal Year: 2012
    ..in diabetic patients designed to provide insight into the mechanism and validation of our previous association with UCP polymorphisms and adverse beta-blocker outcomes...
  42. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
    ..metabolism and high catabolism via upregulation of monocarboxylate transporter 4 (MCT4) and uncoupling protein 1 (UCP1) to determine if changes in the metabolism of the epithelial or stromal compartment are sufficient to increase ..
  43. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..In this proposal, we will test the hypothesis that expression of uncoupling protein (UCP)-2, as an adaptive process within mitochondria from hibernating and preconditioned heart tissue in the "Second ..
  44. GENETICS OF DEVELOPMENTAL PLASTICITY IN THE ADIPOCYTE
    LESLIE KOZAK; Fiscal Year: 2004
    ..Using Ucp1 mRNA levels as a marker for the extent of brown fat induction in retroperitoneal fat (which is normally white fat ..
  45. Beta-ARs and Diet-Induced Thermogenesis
    BRADFORD LOWELL; Fiscal Year: 2007
    ..Evidence supports the view that brown fat may be responsible for diet-induced thermogenesis, and that UCP1-driven uncoupled respiration is the intracellular mechanism...
  46. Heterotopic bone from stem cells in peripheral nerves released by neurogenic infl
    ALAN ROBERT DAVIS; Fiscal Year: 2013
    ..We observed the expression of osteogenic protein osterix, brown adipocyte protein UCP1, and the primitive stem cell factors, Klf4 and nanog...
  47. DIETARY OMEGA-3 FATTY ACIDS, GENE EXPRESSION AND GROWTH
    William Heird; Fiscal Year: 2001
    ..and peroxisomal oxidation as well as the skeletal muscle content of the putative thermogenic uncoupling protein (UCP)-2...
  48. Health promotion: persons with disabilities partner with the academy
    Mary Segal; Fiscal Year: 2009
    ..for Excellence in Developmental Disabilities, and United Cerebral Palsy of Central Pennsylvania, with the national UCP office in support...
  49. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2007
    ..advanced glycation endproducts derived from these substrates, and diabetic retinopathy in uncoupling protein-2 (UCP-2) knockout and glyoxalase I transgenic mice...
  50. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2006
    ..advanced glycation endproducts derived from these substrates, and diabetic retinopathy in uncoupling protein-2 (UCP-2) knockout and glyoxalase I transgenic mice...
  51. REGULATION OF ENERGY BALANCE--INTESTINAL MECHANISMS
    Richard Atkinson; Fiscal Year: 1999
    ..Also to assess uncoupling protein (UCP) and UCP mRNA in brown adipose tissue, NE turnover in multiple organs, and the ability to adrenergic antagonists to ..
  52. Function and regulation of cardiac uncoupling proteins
    Raymond Russell; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The expression of the mitochondrial uncoupling proteins (UCP) 2 and UCPS in the heart has been shown to change in response to a variety of metabolic stressors, including pressure overload and ..
  53. Structure and Function of the Mitochondrial Uncoupling Proteins
    James Chou; Fiscal Year: 2007
    ..We propose detailed structural studies on UCP1 and UCP2 at various physiological states. The proposal consists of two aims...
  54. GENETIC AND PHYSIOLOGICAL REGULATION IN BROWN ADIPOCYTES
    Michael Sitrin; Fiscal Year: 2004
    ..b>UCP1 controls the thermogenic activity of BAT and is the defining gene product of the brown adipocyte...
  55. Synaptogenesis mechanisms revealed by protein printing
    JAMES CAMPANELLI; Fiscal Year: 2002
    ..Toward this long term goal, a technique of patterning proteins on glass coverslips (microcontact printing:uCP) will be employed to covalently immobilize proteins in micron-scale patterns on glass coverslips suitable for ..
  56. PROLACTIN IN ADIPOSE TISSUE DEVELOPMENT AND FUNCTION
    Jon Oden; Fiscal Year: 2003
    ..These studies should provide new information regarding the roles of the lactogens in lipid metabolism. ..
  57. MECHANISMS OF UCP REGULATION BY LEPTIN
    Thomas Gettys; Fiscal Year: 2001
    ..Specific aims are proposed to test three hypotheses: (1) leptin regulates UCP1 UCP2 and UCP3 mRNA and expression in adipose tissue (brown adipose tissue and skeletal muscle in case of UCP3); (2) ..
  58. ION TRANSPORT MECHANISMS IN MITOCHONDRIA
    Keith Garlid; Fiscal Year: 1999
    This is a project ot study mitochondrial uncoupling protein (UCP) with the long-term goals of elucidating its mechanism and regulation of proton transport and understanding its structural dynamics within the membrane...
  59. Does UCP2/3 Overexpression Mimic Caloric Restriction?
    Barbara Horwitz; Fiscal Year: 2005
    ..We have transgenic mice that over express mitochondrial uncoupling proteins (UCP)-2 and 3, decreasing protonmotive force and presumably resulting in mitochondria that generate less ROS...
  60. EXERCISE, DENERVATION AND INSULIN RESISTANCE IN MUSCLE
    Paul Pilch; Fiscal Year: 2005
    ..determine the biochemical pathway(s) by which AMPK activation in skeletal muscle leads to GLUT4 translocation and UCP-3 gene transcription...
  61. Mechanism Regulating Expression of the UCP2 Gene
    Sheila Collins; Fiscal Year: 2005
    ..with Daniel Ricquier, we reported the discovery of uncoupling protein 2 (UCP2), a homologue of the brown fat UCP with genetic linkage to hyperinsulinemia...
  62. BONE GROWTH IN DENTAL, CRANIAL AND SKELETAL TISSUES
    Irving Shapiro; Fiscal Year: 2006
    ..of caspase-3, and/or non-cytochrome c dependent caspase systems and apoptosis; (B) to learn if Uncoupling Protein (UCP) is expressed by maturing chondrocytes: to ascertain if UCP expression is related to loss of transmembrane ..
  63. Does perinatal exposure to Bisphenol A contribute to adult obesity
    BEVERLY RUBIN; Fiscal Year: 2007
    ..They include C/EBP-alpha, PPAR-gamma, FAS, Glut-4, HSL, and leptin in white adipose tissue, UCP1 in brown adipose tissue, and POMC and NPY in the hypothalamus...
  64. Role of perilipin in lipolysis and energy metabolism
    P Gullicksen; Fiscal Year: 2003
    ..FA stimulate uncoupling protein-1 (UCP1) activity in the brown adipose tissue (BAT) of rodents resulting in the generation of heat at the expense of the FA...
  65. Health promotion: persons with disabilities partner with the academy
    Jeffrey Cooper; Fiscal Year: 2009
    ..Duringthe first year, a team from Temple will meet monthlya team from UCP- Central PA, including members of the communitywho have intellectual/developmental disabilities...