TYMS

Summary

Gene Symbol: TYMS
Description: thymidylate synthetase
Alias: HST422, TMS, thymidylate synthase, TSase
Species: human

Top Publications

  1. doi Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin
    Seung Hyeun Lee
    Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Korea University, 126 1, Anam Dong 5 Ga, Seongbuk gu, Seoul 136 705, Republic of Korea
    Lung Cancer 81:102-8. 2013
  2. ncbi One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Carcinogenesis 26:2164-71. 2005
  3. ncbi Prognostic value of thymidylate synthase expression in patients with p-stage I adenocarcinoma of the lung
    Tatsuo Nakagawa
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8397, Japan
    Lung Cancer 35:165-70. 2002
  4. ncbi New prognostic indicator for non-small-cell lung cancer, quantitation of thymidylate synthase by real-time reverse transcription polymerase chain reaction
    Yasushi Shintani
    Department of Surgery, E1, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 104:790-5. 2003
  5. ncbi Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    Anders Jakobsen
    Danish Colorectal Cancer, Group South, Vejle Hospital, 7100 Vejle, Denmark
    J Clin Oncol 23:1365-9. 2005
  6. pmc Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC
    Xia Wang
    Department of Oncology, First Affiliated Hospital of Liaoning Medical College, Jinzhou, China
    J Biomed Sci 20:5. 2013
  7. doi Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trial
    Marianne C Nicolson
    Thoracic Oncology, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, United Kingdom
    J Thorac Oncol 8:930-9. 2013
  8. pmc Reexamining a proposal: thymidylate synthase 5'-untranslated region as a regulator of translation efficiency
    Soma Ghosh
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
    Cancer Biol Ther 12:750-5. 2011
  9. doi TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy
    Luis Alberto Henríquez-Hernández
    Clinical Science Department, Universidad de Las Palmas de Gran Canaria, Spain
    Cancer Epidemiol 34:490-3. 2010
  10. ncbi Structural and functional analysis of the human thymidylate synthase gene
    S Kaneda
    Department of Immunology and Virology, Saitama Cancer Center Research Institute, Japan
    J Biol Chem 265:20277-84. 1990

Research Grants

  1. Effects of aging on swallowing physiology with transient cortical disruption
    Ianessa A Humbert; Fiscal Year: 2013
  2. Monica A Perez; Fiscal Year: 2016
  3. Correlative Studies for NCI Study#7916: Phase I Clinical Trial of Intravenous FAU
    Patricia Mucci LoRusso; Fiscal Year: 2010
  4. THYMIDYLATE SYNTHASE AND FLUORODEOXYURIDINE RESISTANCE
    Franklin G Berger; Fiscal Year: 2012
  5. CELLULAR EFFECTS OF INHIBITION OF THYMIDYLATE SYNTHASE
    RICHARD MORAN; Fiscal Year: 1993
  6. 5 FLUOROURACIL TARGET IN EUKARYOTIC CELLS
    David Priest; Fiscal Year: 2000
  7. Zhewu Wang; Fiscal Year: 2015
  8. Ela B Plow; Fiscal Year: 2015
  9. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2011
  10. Ronald L Cowan; Fiscal Year: 2014

Detail Information

Publications277 found, 100 shown here

  1. doi Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin
    Seung Hyeun Lee
    Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Korea University, 126 1, Anam Dong 5 Ga, Seongbuk gu, Seoul 136 705, Republic of Korea
    Lung Cancer 81:102-8. 2013
    Increased expression of thymidylate synthase (TS) is thought to be associated with resistance to antifolate drugs such as pemetrexed...
  2. ncbi One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Carcinogenesis 26:2164-71. 2005
    ..genes for methylenetetrahydrofolate reductase), MTR A2756G (gene for methionine synthase) and TS (gene for thymidylate synthase) tandem repeats polymorphisms, have attracted attention...
  3. ncbi Prognostic value of thymidylate synthase expression in patients with p-stage I adenocarcinoma of the lung
    Tatsuo Nakagawa
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8397, Japan
    Lung Cancer 35:165-70. 2002
    We investigated thymidylate synthase (TS) expression in tumor tissues and examined the relationship between TS expression and post-operative survival in patients with p-stage I adenocarcinoma of the lung...
  4. ncbi New prognostic indicator for non-small-cell lung cancer, quantitation of thymidylate synthase by real-time reverse transcription polymerase chain reaction
    Yasushi Shintani
    Department of Surgery, E1, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 104:790-5. 2003
    b>Thymidylate synthase (TS) is an enzyme that catalyzes an important DNA biosynthesis process. The gene expression of TS has not been reported in non-small-cell lung cancer (NSCLC) patients...
  5. ncbi Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    Anders Jakobsen
    Danish Colorectal Cancer, Group South, Vejle Hospital, 7100 Vejle, Denmark
    J Clin Oncol 23:1365-9. 2005
    To analyze thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with respect to fluorouracil (FU) sensitivity.
  6. pmc Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC
    Xia Wang
    Department of Oncology, First Affiliated Hospital of Liaoning Medical College, Jinzhou, China
    J Biomed Sci 20:5. 2013
    b>Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response...
  7. doi Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trial
    Marianne C Nicolson
    Thoracic Oncology, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, United Kingdom
    J Thorac Oncol 8:930-9. 2013
    ..retrospective analyses of patients with nonsquamous non-small-cell lung cancer treated with pemetrexed, low thymidylate synthase (TS) expression is associated with better clinical outcomes...
  8. pmc Reexamining a proposal: thymidylate synthase 5'-untranslated region as a regulator of translation efficiency
    Soma Ghosh
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
    Cancer Biol Ther 12:750-5. 2011
    The DNA replicative gene, thymidylate synthase (TYMS), is inhibited upon treatment with the anticancer drug 5-fluorouracil (5FU)...
  9. doi TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy
    Luis Alberto Henríquez-Hernández
    Clinical Science Department, Universidad de Las Palmas de Gran Canaria, Spain
    Cancer Epidemiol 34:490-3. 2010
    The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms was investigated in 80 consecutive breast cancer patients treated with adjuvant chemotherapy.
  10. ncbi Structural and functional analysis of the human thymidylate synthase gene
    S Kaneda
    Department of Immunology and Virology, Saitama Cancer Center Research Institute, Japan
    J Biol Chem 265:20277-84. 1990
    The complete nucleotide sequence of the human thymidylate synthase (TS) gene was determined. The biologically active unit spans about 16 kilobase pairs (kbp) and is composed of seven exons and six introns...
  11. pmc Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma
    N A Wong
    Department of Pathology, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG
    Br J Cancer 85:1937-43. 2001
    b>Thymidylate synthase (TS) is a key enzyme in DNA synthesis and is inhibited by metabolites of the chemotherapeutic agent 5-fluorouracil (5FU)...
  12. ncbi Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine
    Hisaya Kawate
    The Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195 7705, USA
    J Biol Chem 277:36304-11. 2002
    b>Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of cancer chemotherapeutic agents (e.g. 5-fluorouracil)...
  13. ncbi Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status
    Wen Tan
    Department of Etiology and Carcinogenesis, Cancer Institute and Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Carcinogenesis 26:1430-5. 2005
    b>Thymidylate synthase (TS) catalyzes the 5,10-methylene-tetrahydrofolate-mediated conversion of deoxyuridine monophosphate to deoxythymydine monophosphate, a nucleotide required for DNA synthesis and repair...
  14. ncbi Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy
    Kazuyuki Kawakami
    Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan
    Clin Cancer Res 11:3778-83. 2005
    To investigate the prognostic role of thymidylate synthase (TS) polymorphisms in gastric cancer patients treated with radical surgery and fluorouracil-based adjuvant chemotherapy.
  15. ncbi Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy
    Cristian Massacesi
    Department of Oncology and Radiotherapy, Ospedali Riuniti, Ancona, Italy
    Cancer 106:1007-16. 2006
    ..in uridine diphosphate glucuronosyl transferase (UGT1A1), methylenetetrahydrofolate reductase (MTHFR), and thymidylate synthase (TS) genes, and the incidence of the adverse effects of irinotecan and raltitrexed in previously heavily ..
  16. ncbi Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxa
    Eva Martinez-Balibrea
    Medical Oncology Service, Institut Catala Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Barcelona, Spain
    Oncol Rep 17:637-45. 2007
    The aim of this study was to investigate the influence of combining thymidylate synthase (TS), X-ray cross complementing factor 1 (XRCC1) and uridine diphosphate glucoronosyltransferase (UGT1A1 *28) polymorphism genotypes in response rate ..
  17. ncbi The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Hum Genet 114:182-5. 2004
    b>Thymidylate synthase (TYMS) and 5,10-methylenetetrahydrofolate reductase (MTHFR) may compete for their common cofactor 5,10-methylenetetrahyhdrofolate (5,10-meTHF)...
  18. doi Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer
    Peter P Grimminger
    Department of General, Visceral and Tumor Surgery, University of Cologne, Germany
    Clin Lung Cancer 11:328-34. 2010
    b>Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are key enzymes in the 5-fluorouracil (5-FU) pathway...
  19. ncbi Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking
    Chang Ming Gao
    Department of Epidemiology, Jiangsu Province Institute of Cancer Research, Nanjing, China
    Asian Pac J Cancer Prev 5:133-8. 2004
    ....
  20. doi Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behçet's disease
    N Duzgun
    Department of Clinical Immunology and Rheumatology, Ankara University, Ankara, Turkey
    Clin Rheumatol 27:1221-5. 2008
    The aim of this study was to assess whether thymidylate synthase (TYMS) genotype, serum homocysteine, and folate concentrations were related to venous thrombosis in Behçet's disease (BD) patients...
  21. pmc Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer
    Colin D Weekes
    University of Colorado Cancer Center, 12801 E 17th Avenue, RC 1 South, Rm 8123, MS 8117, Aurora, CO 80045, USA
    Invest New Drugs 29:1057-65. 2011
    ..toxicity associated with second-line capecitabine treatment of advanced pancreatic cancer patients harboring the TYMS *2/*2 allele...
  22. ncbi Correlation between thymidylate synthase gene variants, RNA and protein levels in primary colorectal adenocarcinomas
    M H Kristensen
    Department of Clinical Pathology, Hospital South, Naestved Hospital, Naestved, Denmark
    J Int Med Res 38:484-97. 2010
    This study was designed to compare thymidylate synthase (TS) genotype, mRNA and protein levels in primary colorectal adenocarcinoma, and to examine the correlation between microsatellite instability (MSI) and TS expression...
  23. ncbi Polymorphisms of thymidylate synthase gene 5'- and 3'-untranslated region and risk of gastric cancer in Koreans
    Dong Jin Yim
    Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, 463 712, South Korea
    Anticancer Res 30:2325-30. 2010
    b>Thymidylate synthase (TS) plays an important role in the conversion of dUMP to dTMP...
  24. doi Gene expression of vascular endothelial growth factor A, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Dis Colon Rectum 54:1026-35. 2011
    ..Regimens containing bevacizumab and 5-fluorouracil have achieved substantial progress in the treatment of colorectal cancer. However, individual responses to bevacizumab vary widely in regard to efficacy and toxicity...
  25. ncbi Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles
    Huai Rong Luo
    Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, People s Republic of China
    Biochem Genet 40:41-51. 2002
    The tandemly repeated 28-bp sequence in the 5'-terminal regulatory region of human thymidylate synthase (TSER), which has been reported to be polymorphic in different populations, was surveyed in 668 Chinese from 9 Han groups, 8 ethnic ..
  26. ncbi Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling
    Xiao Feng Le
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:2092-104. 2005
    ..Transcriptional regulation by anti-HER2 antibody through PI3K-AKT pathway may potentiate the growth inhibitory activity of docetaxel by affecting cell cycle progression...
  27. pmc Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer
    M Gusella
    Laboratory of Pharmacology and Molecular Biology, Oncology Department, Azienda ULSS 18 Rovigo, Trecenta, Italy
    Br J Cancer 100:1549-57. 2009
    ..5FU pharmacokinetics was evaluated at the first cycle. Thymidylate synthase (TYMS) 5'UTR and 3'UTR polymorphisms and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C ..
  28. ncbi Pharmacogenetics of capecitabine in advanced breast cancer patients
    Remy Largillier
    Centre Antoine Lacassagne, Nice, and Pharmacokinetic Unit, La Timone University Hospital, Marseille, France
    Clin Cancer Res 12:5496-502. 2006
    ..Genes for which polymorphisms may potentially influence pharmacodynamics of fluoropyrimidines, including capecitabine, are thymidylate synthase (TS), methylenetetrahydrofolate reductase (MTHFR), and dihydropyrimidine dehydrogenase (DPD).
  29. doi Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer
    Egbert F Smit
    Department of Pulmonary Diseases, Vrije Universiteit Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Oncol 27:2038-45. 2009
    ..We performed a randomized phase II trial comparing pemetrexed with pemetrexed plus carboplatin (PC) in patients experiencing relapse after platinum-based chemotherapy...
  30. doi The efficacy of pemetrexed as a third- or fourth-line therapy and the significance of thymidylate synthase expression in patients with advanced non-small cell lung cancer
    Myung Hee Chang
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Seoul 135 710, Republic of Korea
    Lung Cancer 69:323-9. 2010
    ..We also analyzed thymidylate synthase (TS) expression in tumor tissues to determine whether TS expression is correlated with the clinical ..
  31. doi Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma
    D Kawakita
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Ann Oncol 23:186-92. 2012
    The association between dietary folate intake, two polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS), and survival in head and neck squamous cell carcinoma (HNSCC) patients is not clarified.
  32. ncbi Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402 Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:2509-16. 2005
    ..1,962 controls), we investigated associations between genetic variants in the reduced folate carrier (RFC), thymidylate synthase (TS), methionine synthase (MTR), and 5,10-methylenetetrahydrofolate reductase (MTHFR) and colon cancer risk...
  33. ncbi Polymorphism in the 3'-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy
    Jian Wei Lu
    Department of Medical Oncology, Jiangsu Province Institute of Cancer Research, Nanjing, 210009, PR China
    J Hum Genet 51:155-60. 2006
    To investigate the relationship between polymorphism in the 3'-untranslated region (3'-UTR) of the thymidylate synthase (TS) gene and sensitivity of gastric cancer to 5-fluorouracil (5-FU)-based chemotherapy, 106 cases of advanced gastric ..
  34. ncbi Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
    Eugenio Marcuello
    Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Int J Cancer 112:733-7. 2004
    b>Thymidylate synthase (TS) is the primary target of 5-fluorouracil (5-FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5-FU-based chemotherapy in colorectal cancer...
  35. ncbi High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer
    Mary Beth Moore Joshi
    Thoracic Oncology Program and Division of Cancer Biostatistics, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 11:2215-21. 2005
    ..To assess the relationship between molecular markers associated with chemotherapy resistance and survival in esophageal cancer patients treated with trimodality therapy...
  36. ncbi Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil
    Erika Hitre
    National Institute of Oncology, Budapest, Hungary
    Pharmacogenet Genomics 15:723-30. 2005
    The present study aimed to prospectively investigate the influence of thymidylate synthase (TS) polymorphisms (5'-TSER, 3'-TSUTR) on the disease-free survival (DFS) and overall survival (OS) of patients with colorectal cancer (CRC) who ..
  37. doi Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group
    Matthias Schwab
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, University of Stuttgart, Stuttgart, Germany
    J Clin Oncol 26:2131-8. 2008
    To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate reductase (MTHFR ) and of nongenetic factors for severe leukopenia, diarrhea, and ..
  38. ncbi Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients
    María Encarnación Fernández-Contreras
    Department of Pathology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid UAM, 28006 Madrid, Spain
    Int J Oncol 34:219-29. 2009
    ..1%) among patients with the unfavourable G&6+/6+ combination. In our study the combination of high TS expression genotypes G&6+/6+ identifies a group of high risk within CRC patients treated with 5FU...
  39. ncbi Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 62:3361-4. 2002
    b>Thymidylate synthase (TS) is a key enzyme in folate metabolism and the primary target of 5-fluorouracil...
  40. ncbi Thymidylate synthase as a translational regulator of cellular gene expression
    Jun Liu
    Department of Medicine and Pharmacology, Yale Cancer Center, Yale University School of Medicine, USA
    Biochim Biophys Acta 1587:174-82. 2002
    Studies from our laboratory have shown that the folate-dependent enzyme, thymidylate synthase (TS), functions as an RNA binding protein...
  41. ncbi Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    Wataru Ichikawa
    Second Department of Surgery, Saitama Medical School, Saitama 350 04925, Japan
    Clin Cancer Res 9:786-91. 2003
    Dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) gene expressions in metastatic colorectal cancer have been reported to be predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy...
  42. ncbi A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    Michael V Mandola
    Department of Molecular Biology, The University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    Cancer Res 63:2898-904. 2003
    b>Thymidylate synthase (TS) gene expression is modulated by a polymorphism in the 5' regulatory region of the gene...
  43. ncbi Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Epidemiol Biomarkers Prev 12:958-62. 2003
    b>Thymidylate synthase (TS) converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis. It is also the target for 5-flurorouracil, the most common chemotherapy agent for treatment of colorectal cancer (CRC)...
  44. ncbi Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene
    Kazumi Uchida
    Department of Biochemistry and Molecular Biology, University of Southern California, School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
    Clin Cancer Res 10:433-9. 2004
    b>Thymidylate synthase (TS), the target enzyme of the fluoropyrimidine class of drugs, has a 28-bp repeat polymorphism in the promoter region that has been associated with response of tumors to 5-fluorouracil-based therapy...
  45. ncbi A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
    Michael V Mandola
    Department of Molecular Biology, The University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    Pharmacogenetics 14:319-27. 2004
    A 6 bp deletion polymorphism in the thymidylate synthase (TS) gene was investigated in order to determine its function.
  46. ncbi Thymidylate synthase repeat polymorphisms and risk of neural tube defects in a population from the northern United Kingdom
    Craig S Wilding
    Genetics Department, Westlakes Research Institute, Cumbria, United Kingdom
    Birth Defects Res A Clin Mol Teratol 70:483-5. 2004
    A 28-bp repeat polymorphism in the 5'UTR of the thymidylate synthase (TYMS) gene represents a candidate risk factor for neural tube defects (NTDs) due to involvement in folate-dependent homocysteine metabolism. Non-Hispanic, white, U.S...
  47. ncbi Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Int J Cancer 120:2226-32. 2007
    b>Thymidylate synthase (TS) is a key enzyme in folate metabolism, a pathway that is important in colorectal carcinogenesis...
  48. doi Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer
    Georg Lurje
    Division of Medical Oncology, Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California 90033, USA
    Pharmacogenet Genomics 18:161-8. 2008
    ..We analyzed the value of thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms as a prognostic marker in stage II ..
  49. doi Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients
    Rohini Sharma
    Department of Molecular Pharmacology, Sydney Cancer Centre, University of Sydney, Sydney, New South Wales, Australia
    Clin Cancer Res 14:817-25. 2008
    To evaluate the effect of thymidylate synthase (TYMS) and methylenetetrahydrofolate reductase (MTHFR) genotypes on toxicity in patients treated with capecitabine for advanced colorectal cancer and to determine the effect of these ..
  50. doi Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer
    Eva Martinez-Balibrea
    Medical Oncology Service, Hospital Universitari Germans Trias i Pujol Institut Català d Oncologia, Badalona, Barcelona, Spain
    Eur J Cancer 44:1229-37. 2008
    ..006) were strong independent prognostic factors. According to this, patients harbouring TS-3'UTR +6bp/+6bp and ERCC1-118C/T or C/C genotypes may better receive capecitabine instead of 5FU in an oxaliplatin-based first-line treatment...
  51. doi Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression
    Ana Patino-Garcia
    Laboratory of Pediatrics, University of Navarra University Clinic, Pamplona, Spain
    J Pediatr 154:688-93. 2009
    ..To determine the influence of the genotype and the level of expression of different enzymes involved in folate metabolism on the response to and toxicity of high-dose methotrexate treatment in pediatric osteosarcomas...
  52. ncbi Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
    S Marsh
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Int J Oncol 19:383-6. 2001
    b>Thymidylate synthase (TS) is an important target for chemotherapy drugs such as 5-fluorouracil and raltitrexed. Over-expression of TS has been linked to chemotherapy resistance...
  53. ncbi Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis
    Kazuhiko Kumagai
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Japan
    Int J Mol Med 11:593-600. 2003
    ..b>Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) are key enzymes in the folate metabolism and both have ..
  54. ncbi Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme
    Lambratu Rahman
    Basic Research Laboratory and Molecular Therapeutic Program, National Institute of Health, Bethesda, MD 20892, USA
    Cancer Cell 5:341-51. 2004
    b>Thymidylate synthase (TS) is an E2F1-regulated enzyme that is essential for DNA synthesis and repair...
  55. ncbi Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
    Thierry Lecomte
    Service de Gastroenterologie, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris
    Clin Cancer Res 10:5880-8. 2004
    The target enzyme for 5-fluorouracil (5-FU) is thymidylate synthase (TS)...
  56. ncbi Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up
    Silke Lassmann
    Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104, Freiburg, Germany
    Int J Colorectal Dis 21:238-47. 2006
    Evaluation of thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and thymidylate synthase (TS) mRNA levels in formalin-fixed, and paraffin-embedded tissues of patients with colorectal cancer and their prognostic and/or ..
  57. pmc Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients
    E Goekkurt
    Department of Haematology and Oncology, University Hospital Hamburg Eppendorf, University of Hamburg, Germany
    Br J Cancer 94:281-6. 2006
    ..1;7.0) in patients with at least one GSTP1-105I allele (P=0.037). Patients possessing a favourable thymidylate synthase (TS) genotype (2R/2R, 2R/3RC, 3RC/3RC) experienced a superior survival time of 10.2 months (95% CI 5.1;15...
  58. ncbi Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis
    Michael H Weisman
    Cedars Sinai Medical Center, Los Angeles, California, USA
    Arthritis Rheum 54:607-12. 2006
    ..This study investigated whether risk genotypes for folate-dependent enzymes are associated with the toxicity of MTX in patients with rheumatoid arthritis (RA)...
  59. ncbi Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment
    Emma Dotor
    Laboratory of Translational Research and Department of Medical Oncology, Institut Català d Oncologia Institut d Investigació de Bellvitge IDIBELL, Barcelona, Spain
    J Clin Oncol 24:1603-11. 2006
    The purpose of this study was to analyze the value of germline and tumor thymidylate synthase (TS) genotyping as a prognostic marker in a series of colorectal cancer patients receiving adjuvant fluorouracil (FU) -based treatment.
  60. ncbi Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy
    Annamaria Ruzzo
    Medical Oncology Unit, Hospital of Urbino, Urbino, Italy
    J Clin Oncol 24:1883-91. 2006
    ..To investigate whether polymorphisms with putative influence on fluorouracil/cisplatin activity are associated with clinical outcomes of patients with advanced gastric cancer (AGC)...
  61. ncbi Thymidylate synthase expression in colon carcinomas with microsatellite instability
    Frank A Sinicrope
    Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 12:2738-44. 2006
    ..Given that thymidylate synthase (TS) is inhibited by 5-FU, we studied the relationship between MSI and TS expression, and the prognostic ..
  62. ncbi Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy
    Jonathan R Brody
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 66:9369-73. 2006
    b>Thymidylate synthase (TS) is an important target for 5-fluorouracil (5FU)-based therapy...
  63. ncbi ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients
    R Takatori
    Dept of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Exp Rheumatol 24:546-54. 2006
    ..5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) C347G and a 6bp-deletion polymorphism in the 3'-untranslated region of the thymidylase synthase (TYMS) gene are predictive of MTX sensitivity and its adverse effects.
  64. ncbi Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 21:509-16. 2006
    Forty genetic variations including 14 novel ones were found in the human TYMS gene, which encodes thymidylate synthase, in 263 Japanese cancer patients who received 5-fluorouracil (FU)-based chemotherapy...
  65. pmc The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195
    Lydia M Gibson
    Department of Chemistry and Biochemistry and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Biochemistry 47:4636-43. 2008
    Loop 181-197 of human thymidylate synthase (hTS) populates two conformational states...
  66. pmc 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Med Genet 10:49. 2009
    ..Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism...
  67. doi Thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil
    David Paez
    Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Pare Claret 167, 08025 Barcelona, Spain
    J Cancer Res Clin Oncol 136:1681-9. 2010
    Chemoradiotherapy using 5-fluorouracil has shown to be effective treatment for rectal cancer. Thymidylate synthase (TS) is an important target enzyme for the fluoropyrimidines...
  68. ncbi [Thymidylate synthase expression and therapeutic effect analysis of pemetrexed in advanced lung adenocarcinoma]
    Zhi Kuan Wang
    Department of Medical Oncology, PLA General Hospital, Beijing 100853, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:978-80. 2010
    To investigate the expression of thymidylate synthase (TS) in patients with advanced lung adenocarcinoma and its relation with the therapeutic effect of pemetrexed.
  69. doi Thymidylate synthase gene polymorphisms effecting 5-FU response in breast cancer patients
    Kalyana Kumar
    Research Department, Indo American Cancer Institute and Research Center, Banjara Hills, Road No 14, Hyderabad, Andhra Pradesh, India
    Cancer Biomark 6:83-93. 2010
    ..The target enzyme for 5- Fluorouracil is thymidylate synthase (TYMS) this enzyme is also involved in folate metabolism...
  70. pmc Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles
    Beibei Luo
    Department of Pharmaceutical Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    Protein Sci 20:87-94. 2011
    b>Thymidylate synthase (TS) is a well-validated cancer target that undergoes conformational switching between active and inactive states...
  71. pmc Association of thymidylate synthase gene polymorphisms with stavudine triphosphate intracellular levels and lipodystrophy
    Pere Domingo
    Infectious Diseases Unit, Hospital de Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 55:1428-35. 2011
    ..Polymorphisms in the thymidylate synthase (TS), methylenetetrahydrofolate reductase (MTHFR), dihydrofolate reductase (DHFR), reduced folate carrier 1 ..
  72. ncbi Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site
    C A Schiffer
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    Biochemistry 34:16279-87. 1995
    The crystal structure of human thymidylate synthase, a target for anti-cancer drugs, is determined to 3.0 A resolution and refined to a crystallographic residual of 17.8%...
  73. ncbi Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
    E Villafranca
    Department of Oncology, Clinica Universitaria, University of Navarre, Pamplona, Spain
    J Clin Oncol 19:1779-86. 2001
    b>Thymidylate synthase (TS) is an important target enzyme for the fluoropyrimidines. TS gene promoter possesses regulatory tandemly repeated (TR) sequences that are polymorphic in humans, depending on ethnic factors...
  74. ncbi Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
    J Phan
    Departments of Chemistry and Biochemistry, University of South Carolina, Columbia 92908, USA
    J Biol Chem 276:14170-7. 2001
    b>Thymidylate synthase (TS) is a major target in the chemotherapy of colorectal cancer and some other neoplasms...
  75. ncbi Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer
    David J Park
    Department of Medical Oncology, Norris Cancer Center, University of Southern California, Los Angeles, USA
    Int J Colorectal Dis 17:46-9. 2002
    b>Thymidylate synthase is a target enzyme for chemotherapeutic agents such as 5-fluorouracil and capecitabine, its oral prodrug...
  76. ncbi Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism
    G J Peters
    Department of Medical Oncology, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Biochim Biophys Acta 1587:194-205. 2002
    b>Thymidylate synthase (TS) is a key enzyme in the de novo synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP) from 2'-deoxyuridine-5'-monophosphate (dUMP), for which 5,10-methylene-tetrahydrofolate (CH(2)-THF) is the methyl donor...
  77. ncbi Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels
    Binh N Trinh
    Department of Surgery, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
    Hum Genet 111:299-302. 2002
    The thymidylate synthase gene ( TYMS or TS) encodes a tightly regulated enzyme that catalyzes the conversion of deoxyuridylate to thymidylate, and contains a tandem repeat polymorphism that affects expression of the enzyme...
  78. ncbi Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer
    Yoshinori Ishida
    Department of Surgery, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa 920 8641, Japan
    Anticancer Res 22:2805-9. 2002
    b>Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil (5-FU). TS has a polymorphic repeated sequence in the 5'-UTR and the polymorphism is associated with TS protein expression...
  79. ncbi Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed
    David C Farrugia
    Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    Clin Cancer Res 9:792-801. 2003
    The purpose of this research was to evaluate the predictive value of expression of thymidylate synthase (TS) and other genes for response to raltitrexed (RTX).
  80. ncbi Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma
    Asahi Hishida
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Haematologica 88:159-66. 2003
    Polymorphisms in thymidylate synthase (TS) 28-bp tandem repeats in the promoter region and in cytosolic serine hydroxymethyltransferase (SHMT1 C1420T) have been reported to modulate the risk of adult acute lymphocytic leukemia (ALL)...
  81. ncbi Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil
    Marko Kornmann
    Department of General Surgery, University of Ulm, Steinhovelstrasse 9, 89075 Ulm, Germany
    Clin Cancer Res 9:4116-24. 2003
    ..In this study, we determined the prognostic value of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression in colorectal cancer patients treated with ..
  82. ncbi Associations between polymorphisms within the thymidylate synthase gene and spina bifida
    Kelly A Volcik
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 67:924-8. 2003
    Polymorphisms within the thymidylate synthase (TS) gene that influence enzyme activity may affect plasma folate levels and, indirectly, plasma homocysteine concentrations...
  83. ncbi Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-pair insertion), and thymidylate synthase (TS enhancer region and 3' untranslated region)--have been investigated in colorectal neoplasia...
  84. pmc A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer
    J Stoehlmacher
    Department of Hematology and Oncology, University of Hamburg, University Hospital, Hamburg 20247, Germany
    Br J Cancer 91:344-54. 2004
    ..genes XPD, ERCC1, XRCC1, XPA, and metabolising genes glutathione S-transferase GSTP1, GSTT1, GSTM1, and thymidylate synthase (TS) were assessed retrospectively in 106 patients with refractory stage IV disease who received 5-FU/..
  85. ncbi Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
    Thierry Dervieux
    Prometheus Laboratories, San Diego, California, USA
    Arthritis Rheum 50:2766-74. 2004
    ..MTXPGs) and inhibition of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (TS)...
  86. ncbi Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype
    Fabienne Grieu
    Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands 6009, Australia
    Anticancer Res 24:3215-9. 2004
    ..Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate ..
  87. ncbi Case-control analysis of thymidylate synthase polymorphisms and risk of lung cancer
    Qiuling Shi
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 26:649-56. 2005
    ..b>Thymidylate synthase (TYMS) is involved in the metabolism of folate and the provision of nucleotides needed for DNA synthesis ..
  88. ncbi Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:7903-10. 2004
    ..We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are ..
  89. ncbi The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells
    Tetsuya Oguri
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Lung Cancer 49:345-51. 2005
    The expressions of thymidylate synthase (TS) and intracellular metabolic enzymes have been reported to be associated with the sensitivity and/or resistance to 5-fluorouracil (5-FU)...
  90. ncbi Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population
    L D Wang
    Laboratory for Cancer Research, Experimental Center for Medicine, College of Medicine, Zhengzhou University, Henan Key Laboratory for Esophageal Cancer, Zhengzhou, Henan Province, China
    Dis Esophagus 18:177-84. 2005
    Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are key enzymes in folate metabolism, which is essential for normal DNA methylation and synthesis...
  91. ncbi Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers
    Maria Morganti
    Dipartimento di Farmacologia, Unità di Chemioterapia, Universita degli Studi di Firenze, Viale Pieraccini, 6, 50139, Firenze, Italy
    Eur J Cancer 41:2176-83. 2005
    b>Thymidylate synthase (TS) intratumoural expression may be a prognostic marker and predict outcome of 5-fluorouracil (5-FU)-based chemotherapy in colorectal cancer patients...
  92. pmc Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis
    Xiangjun Zhai
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China
    BMC Cancer 6:138. 2006
    ..b>Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP ..
  93. ncbi Germline polymorphisms may act as predictors of response to preoperative chemoradiation in locally advanced T3 rectal tumors
    Karen Lise G Spindler
    Department of Oncology, Vejle Hospital, Vejle, Denmark
    Dis Colon Rectum 50:1363-9. 2007
    ..This study was designed to investigate the predictive value of a new combination of three gene polymorphisms: thymidylate synthase, epidermal growth factor receptor Sp1-216, and epidermal growth factor A61G.
  94. ncbi G>C SNP of thymidylate synthase with respect to colorectal cancer
    Milena Gusella
    Rovigo General Hospital, Oncology Division, Viale Tre Martiri 89, 45100 Rovigo, Italy
    Pharmacogenomics 8:985-96. 2007
    Several studies indicate that low thymidylate synthase (TS) protein levels in tumor and normal tissues of colorectal cancer patients are associated with better clinical response to fluorouracil-based chemotherapy and higher risk of ..
  95. pmc Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma
    R A Hubner
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK
    Br J Cancer 97:1449-56. 2007
    ....
  96. pmc Polymorphism of thymidylate synthase gene associated with its protein expression in human colon cancer
    Kai Huan Yu
    Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 14:617-21. 2008
    To correlate the polymorphisms in the 5'-untranslated region with thymidylate synthase (TS) protein expression in Han Chinese colonic neoplasms.
  97. ncbi Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis
    Prabha Ranganathan
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Rheumatol 35:572-9. 2008
    ..We examined the influence of MTX transporter gene polymorphisms on MTX toxicity in 2 racial groups of patients with RA...
  98. pmc Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
    Sudha Mannava
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cell Cycle 7:2392-400. 2008
    ..These included thymidylate synthase (TS), inosine monophosphate dehydrogenase 2 (IMPDH2) and phosphoribosyl pyrophosphate synthetase 2 (PRPS2)...
  99. doi Toxicity and efficacy of 5-fluorouracil and capecitabine in a patient with TYMS gene polymorphism: A challenge or a dilemma?
    Armin Shahrokni
    Yale University School of Medicine, New Haven, CT, USA
    Clin Colorectal Cancer 8:231-4. 2009
    ..The active metabolite, 5-fluorodeoxyuridine monophosphate inhibits thymidylate synthase (TS), thus preventing DNA synthesis, which leads to imbalanced cell growth and ultimately cell death...
  100. ncbi Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study
    L A Henríquez-Hernández
    Clinical Science Department, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
    Oncol Rep 22:1425-33. 2009
    ..05). Gene polymorphisms vary by regions. The present study contributes to the characterization of the genetic pattern of the Canary population...
  101. doi Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo
    C E de Bock
    Leukaemia Foundation Laboratory, Division of Cancer and Cell Biology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Pharmacogenomics J 11:307-14. 2011
    Two known polymorphisms in the 5' enhancer region (ER) of the thymidylate synthase (TS) gene, a variable number of tandem repeats of a 28 bp sequence (2R/3R) and a further G>C single nucleotide substitution within the repeats, result ..

Research Grants67

  1. Effects of aging on swallowing physiology with transient cortical disruption
    Ianessa A Humbert; Fiscal Year: 2013
    ..We will apply single-pulse transcranial magnetic stimulation (TMS) to the bilateral SMI laryngeal representation with concurrent video fluoroscopy and electromyography (EMG) during ..
  2. Monica A Perez; Fiscal Year: 2016
    ..Transcranial magnetic stimulation (TMS) will be used to examine excitability of intracortical pathways and corticospinal drive...
  3. Correlative Studies for NCI Study#7916: Phase I Clinical Trial of Intravenous FAU
    Patricia Mucci LoRusso; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The thymidylate synthase (TS) inhibitor 5-fluorouracil (5FU) is the "backbone" of cancer treatment in many malignancies. Unfortunately, tumors can be resistant to 5FU due to upregulation of TS...
  4. THYMIDYLATE SYNTHASE AND FLUORODEOXYURIDINE RESISTANCE
    Franklin G Berger; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Thymidylate synthase (TS) catalyzes the reductive methylation of dUMP to dTMP, a reaction that is essential for the de novo biosynthesis of dTTP for DNA replication and cell proliferation...
  5. CELLULAR EFFECTS OF INHIBITION OF THYMIDYLATE SYNTHASE
    RICHARD MORAN; Fiscal Year: 1993
    Inhibition of the key enzyme thymidylate synthase (TS) is a major cause of the activity of 5-fluorouracil (5-FU) as a cancer chemotherapeutic agent...
  6. 5 FLUOROURACIL TARGET IN EUKARYOTIC CELLS
    David Priest; Fiscal Year: 2000
    ..application would investigate folate-based control of CpG site methylation in the promoter region of the thymidylate synthase gene leading to attenuation of expression...
  7. Zhewu Wang; Fiscal Year: 2015
    ..inhibition (SICI) and intra-cortical facilitation (ICF) measured through transcranial magnetic stimulation (TMS) is associated with combat related PTSD...
  8. Ela B Plow; Fiscal Year: 2015
    ..plasticity in the surviving cortices using non-invasive brain stimulation (Transcranial Magnetic Stimulation, TMS, and Transcranial Direct Current Stimulation, tDCS) to enhance efficacy of rehabilitation...
  9. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2011
    ..In particular, N5,N10 methylene tetrahydrofolate is required by thymidylate synthase to convert dUMP to TMP, which is the only de novo source of TMP...
  10. Ronald L Cowan; Fiscal Year: 2014
    ..mechanism to explore the neural mechanism for these findings by: 1) by using transcranial magnetic stimulation (TMS) in visual and motor cortex to demonstrate MDMA users have increased cortical excitability and, 2) to use magnetic ..
  11. ADAM ROBERT ARON; Fiscal Year: 2016
    ..We will use Transcranial Magnetic Stimulation (TMS) to examine the difference between global and selective stopping by identifying effects on motor representations in ..
  12. Scott H Frey; Fiscal Year: 2016
    ..Our approach combines functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) to determine changes occurring within the former hand territory, and behavioral testing to establish their ..
  13. Transcranial Direct Current Stimulation and Motor Training in Chronic Stroke
    DYLAN JAMES EDWARDS; Fiscal Year: 2010
    ..We plan to use accepted TMS measures of cortical excitability, together with a novel twitch torque measure and motor control measures, to test ..
  14. Stewart H Mostofsky; Fiscal Year: 2016
    ..Using Transcranial Magnetic Stimulation (TMS) in motor cortex, we found that Short Interval Cortical Inhibition (SICI), which is mediated by GABAergic ..
  15. Donald L Gilbert; Fiscal Year: 2016
    ..Using Transcranial Magnetic Stimulation (TMS) in motor cortex, we found that Short Interval Cortical Inhibition (SICI), which is mediated by GABAergic ..
  16. Transcranial Magnetic Stimulation for Treatment of Obsessive Compulsive Disorder
    Antonio Mantovani; Fiscal Year: 2012
    ..OCD, 2) to evaluate the safety of fMRI-guided rTMS in OCD, and 3) to explore the impact of rTMS to the pre-SMA on TMS measures of motor cortex excitability in OCD...
  17. Motor cortex dysfunction in migraine
    Jing Xiang; Fiscal Year: 2011
    ..can be treated and/or prevented by normalizing cortical excitability with transcranial magnetic stimulation (TMS), medications and other methods...
  18. TMS Effects on Pain Perception
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..The candidate will become familiar with new treatments such as transcranial magnetic stimulation (TMS), vagus nerve stimulation, and deep brain stimulation...
  19. Amy J Bastian; Fiscal Year: 2015
    ..In aim 2 we will use transcranial magnetic stimulation (TMS) to test whether gradual motor learning is more associated with increased excitability in primary motor cortex, ..
  20. David J Ostry; Fiscal Year: 2016
    ..We will use trans-cranial magnetic stimulation (TMS) to test for changes associated with somatosensory training in the excitability of primary motor cortex...
  21. Behavioral and Neurophysiological Mechanisms of Interference in Skill Learning
    GABRIELA LUCILA CANTARERO; Fiscal Year: 2012
    ..excitability changes in the motor cortex resulting from training and tDCS, transcranial magnetic stimulation (TMS) will be used to assess the magnitude of saturation (homeostatic plasticity) associated with practicing the task in ..
  22. Michael D Fox; Fiscal Year: 2016
    ..motor network, where propagation of focal brain stimulation can be measured with transcranial magnetic stimulation (TMS)...
  23. Identification of post-transcriptionally regulated targets by TrIP-Chip/Seq
    Jingfang Ju; Fiscal Year: 2013
    ..Our recent studies revealed that miR-215 is involved in regulating some key anticancer targets, e.g. thymidylate synthase and dihydrofolate reductase...
  24. Bhaumik B Patel; Fiscal Year: 2016
    ..At the same time, expression of thymidylate synthase (TS), the putative target of miR-215, as well as integrin alpha-V (CD51) and myeloid cell leukemia-1 (MCL-1)..
  25. Mechanisms of cerebral palsy recovery induced by balancing motor cortex activity
    KATHLEEN MARGARET FRIEL; Fiscal Year: 2012
    ..The applicant will obtain training in TMS, human motor skill assessment and analysis, and translating hypotheses between the animal and the human...
  26. Richard Ivry; Fiscal Year: 2014
    ..dynamics during the selection and initiation of movements as measured with transcranial magnetic stimulation (TMS) of the motor cortex...
  27. Andrew L Lee; Fiscal Year: 2016
    ..paired with small molecule synthesis and steady-state kinetics, will be applied to a 64 kD enzyme, thymidylate synthase (TS), from E. coli...
  28. MARIA MARJORETTE PENA; Fiscal Year: 2015
    ..Inhibitors of the enzyme thymidylate synthase (TS), particularly fluoropyrimidines, have been used for many years in the clinical management of a variety ..
  29. Optimization of pyrimidinyl prodrugs (PYPs) for malaria chemotherapy
    PRADIPSINH RATHOD; Fiscal Year: 2009
    ..hit: Over the last two decades, the PI has systematically considered multiple ways to attack malarial thymidylate synthase with nanomolar-level enzyme inhibitors active in whole cell assays...
  30. Using TMS to enhance off-line learning.
    Edwin Robertson; Fiscal Year: 2009
    ..When Transcranial Magnetic Stimulation (TMS) is applied to the primary motor cortex (M1) the rate of subsequent skill learning can be increased in normal ..
  31. Conotruncal defects: genetic and nutritional risk
    EDWARD JAMES LAMMER; Fiscal Year: 2010
    ..reductase, betaine homocysteine methyltransferases 1&2, N-acetyltransferase 1, and thymidylate synthase);2) studying genetic variation of two folate transporters, folate receptor-alpha and reduced folate carrier;..
  32. Larry H Matherly; Fiscal Year: 2015
    ..Another cytotoxic hPCFT substrate, AG112, was a potent inhibitor of thymidylate synthase. AG71 was tested in vivo against subcutaneous human hepatoma cells in SCID mice and showed potent hPCFT-..
  33. Donna S Shewach; Fiscal Year: 2014
    ..as hydroxyurea (ribonucleotide reductase inhibitor), and fluorodeoxyuridine, methotrexate and pemetrexed (thymidylate synthase inhibitors) to produce the first unifying hypothesis for antimetabolite radiosensitization...
  34. Prognostic Molecular Markers of Colorectal Cancer
    Upender Manne; Fiscal Year: 2009
    ..in colon cancer), p53, p21waf-1, p27Kip-1, Mdm2, cyclin E, Ki67, Bcl-2, Bax, MUC1, cyclooxygenase 2, and thymidylate synthase. The extent of apoptosis will be determined utilizing TUNEL...
  35. Chemotherapy targeting human thymidylate synthase messenger RNA
    THOMAS C HERMANN; Fiscal Year: 2013
    ..The proposed research is intended to discover novel anti-cancer agents that inhibit expression of thymidylate synthase (TS), the sole intracellular de novo source of thymidylate for DNA biosynthesis...
  36. Genetic determinants associated with pemetrexed response and toxicity
    M Eileen Dolan; Fiscal Year: 2013
    ..The most significant interaction at clinically achievable concentrations is with thymidylate synthase (TYMS), although the drug is known to target at least two other folate dependent enzymes...
  37. Amnon Kohen; Fiscal Year: 2016
    ..A mechanistic investigation of C-H bond activation in alternative dihydrofolate reductases (DHFRs) and thymidylate synthase (TSase) will be conducted...
  38. RELATION OF THYMIDYLATE SYNTHASE STRUCTURE TO FUNCTION
    JAMES APPLEMAN; Fiscal Year: 1992
    b>Thymidylate synthase (TS) catalyzes the conversion of dUMP and [6R]-5,10- methylenetetrahydrofolate (CH2H4folate) to dTMP and H2folate by reductive methylation, in which CH2H4folate is both methyl donor and reducing agent...
  39. THYMIDYLATE SYNTHASE GENE EXPRESSION
    Lee Johnson; Fiscal Year: 2002
    b>Thymidylate synthase (TS) is an essential enzyme in proliferating cells and an important target of chemotherapeutic drugs...
  40. MULTISUBSTRATE ENZYME INHIBITORS
    ARTHUR BROOM; Fiscal Year: 1991
    The long range goals of the project are to develop potent and specific multisubstrate inhibitors of thymidylate synthase, to use these as probes to study the active site of the enzyme and to develop from this information useful new ..
  41. CRYSTALLOGRAPHIC STUDIES OF THYMIDYLATE SYNTHASE
    Janet Finer Moore; Fiscal Year: 2003
    The broad objectives of the work are to understand the functions of thymidylate synthase (TS) and other nucleotide, RNA and DNA-modifying enzymes...
  42. A Molecular Approach For Opportunistic HIV-1 Infections
    Karen Anderson; Fiscal Year: 2007
    ..Two enzymes crucial for DNA synthesis and one-carbon transfers are thymidylate synthase and dihydrofolate reductase...
  43. Prognostic Markers in Trials for Head and Neck Cancer
    Kevin Cullen; Fiscal Year: 2005
    Our fundamental hypothesis is that readily identifiable biomarkers, including p53, thymidylate synthase and enzymes in the glutathione pathway are critical determinants of response and long term outcome for patients receiving chemotherapy ..
  44. fMRI and TMS of Motor Recovery after Hemiparetic Stroke
    Judith Schaechter; Fiscal Year: 2007
    This application is for a Mentored Patient-Oriented Research Career Development Award entitled "fMRI and TMS of Motor Recovery after Hemiparetic Stroke"...
  45. Ralph D Freeman; Fiscal Year: 2014
    ..coupling by the application of electrical stimulation in the form of transcranial magnetic stimulation (TMS). Our first goal is to study neural and hemodynamic functional connectivity in the LGN and visual cortex...
  46. NEURAL SUBSTRATES FOR CONTROL OF REACHING IN HUMANS
    GARRETT ALEXANDER; Fiscal Year: 2004
    ..changes in regional cerebral blood flow (rCBF) in normal human volunteers, and transcranial magnetic stimulation (TMS) will be used to reversibly disrupt the functioning of selected cortical areas of subjects performing a variety of ..
  47. Transcranial Magnetic Stimulation Laboratory
    Sabine Kastner; Fiscal Year: 2002
    ..Transcranial magnetic stimulation (TMS) is a technique that offers the unique possibility to create a transient virtual lesion by inducing cortical ..
  48. The Respiratory-motor Coupling
    Sheng Li; Fiscal Year: 2012
    ..in corticospinal excitability associated with voluntary breathing (Aim 1) using transcranial magnetic stimulation (TMS) and neuromuscular electrical stimulation (ES) in a variety of tasks in normal subjects...
  49. NCI OUTSTANDING INVESTIGATORS GRANT
    Frank Maley; Fiscal Year: 2000
    Because of the role that thymidylate synthase (TS) and deoxycytidylate deaminase (DD) play in providing nucleotide products for DNA synthesis, they have become prime targets for chemotherapy...
  50. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..that each inhibit VEGFR-2 and PDGFR-$, (tumor angiogenic effects) and remarkably also inhibit human thymidylate synthase (hTS) (cytotoxic effects)...
  51. EDITING OF THYMIDYLATE SYNTHASE RNA
    BRUCE DOLNICK; Fiscal Year: 2002
    b>Thymidylate synthase is the enzyme responsible for the de novo synthesis of thymidylate and is a major target in chemotherapy...
  52. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ..Recent studies indicate that the clinically used TS inhibitors 5FU, 5FdR, AD1694, and LY23154 all induce thymidylate synthase (TS) synthesis...
  53. NIH Director's Pioneer Award
    Karl Deisseroth; Fiscal Year: 2009
    ..abstract_text> ..
  54. Factors influencing regulation of the dynamics of the actin filament pointed end
    Alla S Kostyukova; Fiscal Year: 2013
    ..TM binding sites on Tmod will be used to learn the structural basis of the specificity of binding of different TMs to different Tmods...
  55. Effects of Psychopathology on Prefrontal Cortical Functioning During Goal-Directe
    Sharon L Thompson Schill; Fiscal Year: 2010
    ..diverse and novel methodologies including behavioral, perfusion fMRI, transcranial magnetic stimulation (TMS), and neuropsychological/clinical studies, and introduces a novel set of tasks that will allow for a better ..
  56. CYP1B1: A Molecular Target for Chemoprevention of Lung Adenocarcinoma
    Margie L Clapper; Fiscal Year: 2013
    ..of CYP1B1 will be achieved by gene deletion or administration of 2,3',4,5'-tetramethoxystilbene (TMS), a synthetic analog of resveratrol that is a selective inhibitor of CYP1B1...
  57. PERMEABILITY OF THE EPIDEMIC TYPHUS RICKETTSIA
    JONATHON PETER AUDIA; Fiscal Year: 2010
    ..We now have an excellent two-dimensional topology for this protein and evidence for which transmembrane domains (TMs) form the water-filled channel through which ATP/ADP crosses the membrane...
  58. JOSEPH JEFFREY TAYLOR; Fiscal Year: 2014
    ..One week later, participants will receive the same TMS treatment but the opposite IV infusion...
  59. Velia M Fowler; Fiscal Year: 2016
    ..capped by tropomodulin-1 (Tmod1) at their pointed ends and 1/2-adducin at their barbed ends, while tropomyosins (TMs) span along the filament length, binding to Tmod1 at the pointed filament end...
  60. RAPIDLY-ACTING TREATMENTS FOR TREATMENT-RESISTANT DEPRESSION (RAPID)
    Maurizio Fava; Fiscal Year: 2011
    ..g., tms, ect, mst)...
  61. Anthony Carruthers; Fiscal Year: 2016
    ..sugar transport, are essential for carbohydrate homeostasis in humans, contain 12 membrane-spanning alpha helices (TMs) which form a translocation pathway (amphipathic TMs 1, 2, 4, 5, 7, 8, 10 and 11) stabilized by a scaffold (..
  62. PRESSURE REGULATION OF HUMAN TRABECULAR MESHWORK GENES
    TERESA BORRAS; Fiscal Year: 2012
    ..uncovered that such processes were not only present in the TM, but also that they seemed to be more active in TMs from glaucomatous patients...
  63. Pathophysiology of Spasmodic Dysphonia: a TMS study
    Teresa Jacobson Kimberley; Fiscal Year: 2013
    ..Transcranial magnetic stimulation (TMS) is a safe, non-invasive tool that can provide extensive information about the neurophysiologic underpinnings in a ..
  64. MARCELO DANIEL CARATTINO; Fiscal Year: 2014
    ..homo- or hetero- trimers and are composed of subunits that have a similar topology with two transmembrane domains (TMs) connected by a large extracellular domain with short intracellular N- and C- termini...
  65. The Thrombin-Thrombomodulin Interaction
    Elizabeth A Komives; Fiscal Year: 2012
    ..Mutant TMs will also be studied...
  66. Molecular mechanisms of voltage-gated proton channels
    Hans Peter Larsson; Fiscal Year: 2013
    ..However, HV channels have only the first 4 TMs and lack a typical pore domain...