TUCAN

Summary

Gene Symbol: TUCAN
Description: caspase recruitment domain family member 8
Alias: CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN, caspase recruitment domain-containing protein 8, CARD inhibitor of NF-kappaB-activating ligands, apoptotic protein NDPP1, tumor up-regulated CARD-containing antagonist of CASP9, tumor up-regulated CARD-containing antagonist of caspase nine
Species: human

Top Publications

  1. doi Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation
    Richard D Bagnall
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Eur J Hum Genet 16:619-25. 2008
  2. doi Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection
    Alessandra Pontillo
    Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Acquir Immune Defic Syndr 59:121-5. 2012
  3. ncbi TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer
    N Pathan
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:32220-9. 2001
  4. ncbi CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways
    L Bouchier-Hayes
    Molecular Cell Biology Laboratory, Department of Genetics, Smurfit Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 276:44069-77. 2001
  5. ncbi CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis
    Marjaneh Razmara
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:13952-8. 2002
  6. ncbi TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation
    Romania Stilo
    BioGeM Consortium, Napoli, Italy
    FEBS Lett 521:165-9. 2002
  7. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
  8. ncbi TUCAN (CARD8) genetic variants and inflammatory bowel disease
    Dermot P B McGovern
    Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK
    Gastroenterology 131:1190-6. 2006
  9. pmc Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease
    Liesbet Henckaerts
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 56:1536-42. 2007
  10. doi Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?
    Deepti Verma
    Linkoping University, Linkoping, Sweden
    Arthritis Rheum 58:888-94. 2008

Research Grants

  1. GEOFFREY SCOTT GOTTLIEB; Fiscal Year: 2014
  2. Robert L Murphy; Fiscal Year: 2016
  3. Northwestern University Clinical Trial Unit
    Robert L Murphy; Fiscal Year: 2011
  4. PET STUDY OF BIOCHEMISTRY AND METABOLISM OF THE CNS
    Kirk A Frey; Fiscal Year: 2012
  5. Dopaminergic Modulation Of Cognitive Aspects Of Skill Acquisition In PD
    Brenda Hanna Pladdy; Fiscal Year: 2010
  6. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2012
  7. Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic Syndrome
    Robert S Schwartz; Fiscal Year: 2010
  8. Genome-Wide Association Scan of Polycystic Ovary Syndrome Phenotypes
    Andrea Dunaif; Fiscal Year: 2010
  9. Beverley Greenwood-Van Meerveld; Fiscal Year: 2016
  10. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012

Detail Information

Publications320 found, 100 shown here

  1. doi Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation
    Richard D Bagnall
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Eur J Hum Genet 16:619-25. 2008
    CARD8 (TUCAN) is implicated in the regulation of apoptosis and inflammation, and is a positional and functional candidate gene for inflammatory bowel disease (IBD)...
  2. doi Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection
    Alessandra Pontillo
    Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Acquir Immune Defic Syndr 59:121-5. 2012
    ..These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection...
  3. ncbi TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer
    N Pathan
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:32220-9. 2001
    ..is overexpressed in some types of cancer and that binds and suppresses activation of procaspase-9, which we term TUCAN (tumor-up-regulated CARD-containing antagonist of caspase nine)...
  4. ncbi CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways
    L Bouchier-Hayes
    Molecular Cell Biology Laboratory, Department of Genetics, Smurfit Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 276:44069-77. 2001
    ..Here we report the identification of a novel protein, CARDINAL, that contains a CARD motif and also exhibits a high degree of homology to the C terminus of DEFCAP/NAC, a ..
  5. ncbi CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis
    Marjaneh Razmara
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:13952-8. 2002
    ..Overexpression of CARD-8 can also induce apoptosis in transfected cells. The results suggest that CARD-8 represents a new signaling molecule involved in the regulation of caspase-1 and NF-kappaB activation...
  6. ncbi TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation
    Romania Stilo
    BioGeM Consortium, Napoli, Italy
    FEBS Lett 521:165-9. 2002
    ..TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-kappaB activation...
  7. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
    ..Here, we report that NALP2 and NALP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not caspase-5), thereby forming an inflammasome with high proIL-1beta-processing activity...
  8. ncbi TUCAN (CARD8) genetic variants and inflammatory bowel disease
    Dermot P B McGovern
    Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK
    Gastroenterology 131:1190-6. 2006
    ..Other susceptibility loci exist. TUCAN (CARD8) is located beneath a CD peak of linkage on chromosome 19q...
  9. pmc Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease
    Liesbet Henckaerts
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 56:1536-42. 2007
    ..receptor genes (nucleotide oligomerisation domain (NOD) 2/caspase recruitment domain (CARD) 15, NOD1/CARD4, TUCAN/CARDINAL/CARD8, Toll-like receptor (TLR) 4, TLR2, TLR1 and TLR6) on the development of antimicrobial and antiglycan ..
  10. doi Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?
    Deepti Verma
    Linkoping University, Linkoping, Sweden
    Arthritis Rheum 58:888-94. 2008
    NALP3, ASC, and TUCAN are components of the NALP3 inflammasome, which triggers caspase 1-mediated interleukin-1beta (IL-1beta) release...
  11. doi Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women
    Ana Fontalba
    Unidad de Genetica Molecular, Marques de Valdecilla University Hospital, Santander, Spain
    Dement Geriatr Cogn Disord 26:247-50. 2008
    ..39-fold higher risk of developing AD than subjects with the CARD8 TT genotype (full-length protein). This association with susceptibility to AD was independent of the ApoE epsilon4 allele...
  12. doi CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis
    Alf Kastbom
    Division of Rheumatology, Linkoping University Hospital, Linkoping, Sweden
    Ann Rheum Dis 69:723-6. 2010
    ..CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated...
  13. pmc A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease
    Dennis C Ko
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 85:214-27. 2009
    ..These results demonstrate the utility of genome-wide cell-based association screens with microbes in the identification of naturally selected variants that can impact human health...
  14. doi Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease
    R L Roberts
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Genes Immun 11:351-6. 2010
    ..48-0.90); P(1,1/1,2)=0.015, OR=0.35, 95% CI (0.15-0.82)). We propose that these genotype combinations protect against gut inflammation by preventing the NALP3 inflammasome from producing excessive interleukin-1beta...
  15. pmc Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling
    Oliver von Kampen
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D 24105, Germany
    J Biol Chem 285:19921-6. 2010
    ..Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells...
  16. doi Association of CARD8 with inflammatory bowel disease in Koreans
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Hum Genet 56:217-23. 2011
    ..The stop allele of rs2043211 was associated with higher serum interleukin-1β levels only in female patients with UC (P = 0.027). Our data suggest that CARD8 variants might have roles in the pathogenesis of CD and UC in Koreans...
  17. ncbi Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity
    Ana Fontalba
    Unidad de Genetica Molecular, Hospital Universitario Marques de Valdecilla, Santander, Spain
    J Immunol 179:4867-73. 2007
    ..03) than the CARD8-L allele carriers. Overall, our findings provide molecular insight into the expression of CARD8 by NF-kappaB, and suggest that a deleterious polymorphism of CARD8 may help predict the severity of RA...
  18. doi Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men
    Ida Schoultz
    Division of Surgery, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Am J Gastroenterol 104:1180-8. 2009
    ..The combination of the polymorphisms CARD8 (C10X)and NALP3 (Q705K) was recently shown to be associated with rheumatoid arthritis.Our aim was to investigate whether these combined polymorphisms play a role in the susceptibility to CD...
  19. pmc Fas-induced apoptosis of renal cell carcinoma is mediated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation
    Mohamed Hassan
    Laboratory for Experimental Molecular Tumour Therapy, Department of Dermatology, University Hospital of Duesseldorf, Duesseldorf, Germany
    Cell Oncol 31:437-56. 2009
    ..Thus, the described molecular mechanisms of CH11-induced apoptosis suggest the reliability of Fas activation as an alternative therapeutic approach for the treatment of patients with advanced renal cell carcinoma...
  20. pmc Vascular mode of action of kinin B1 receptors and development of a cellular model for the investigation of these receptors
    L Levesque
    , , Canada
    Br J Pharmacol 109:1254-62. 1993
    ..The cell model retains some of the cardinal properties of B1 receptor-mediated vascular responses: endothelium independent PGI2 release and up-regulation by ..
  21. pmc Renal effects of environmental and occupational lead exposure
    M Loghman-Adham
    Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Environ Health Perspect 105:928-38. 1997
    ..studies have shown an association between blood lead levels and blood pressure, and hypertension is a cardinal feature of lead nephropathy...
  22. ncbi Modulation of catecholamine storage and release by the pituitary-interrenal axis in the rainbow trout, Oncorhynchus mykiss
    S G Reid
    Department of Biology, University of Ottawa, Ontario, Canada
    J Comp Physiol B 165:665-76. 1996
    ..Increases in the levels of stored catecholamines were observed in various regions of the kidney and posterior cardinal vein following 3 and 7 days of cortisol treatment...
  23. ncbi Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis
    Athanasios Covanis
    Neurology Department, Agia Sophia Children s Hospital, Thivon and Levadias, Goudi, 11527 Athens, Greece
    Pediatrics 118:e1237-43. 2006
    ..It is characterized by seizures, often prolonged, with predominantly autonomic symptoms, and by an EEG [electroencephalogram] that shows shifting and/or multiple foci, often with occipital predominance."..
  24. ncbi Assay of fipronil efficacy to prevent canine monocytic ehrlichiosis in endemic areas
    B Davoust
    Direction Régionale du Service de Santé des Armées, BP 16, Armees, 69998 Lyon, France
    Vet Parasitol 112:91-100. 2003
    ..of Ehrlichia canis transmission to dogs by Rhipicephalus sanguineus in two endemic areas situated in Africa (Dakar and Djibouti)...
  25. ncbi Vault prolapse I: Dynamic supports of the vagina
    P E Petros
    Royal Perth Hospital, Western Australia, Australia
    Int Urogynecol J Pelvic Floor Dysfunct 12:292-5. 2001
    ..The relevance of muscle forces to the three anatomical levels of support, the cardinal/uterosacral ligament complex (level 1), the rectovaginal fascia (level 2) and the perineal body (level 3), was ..
  26. ncbi Is thermal scanner losing its bite in mass screening of fever due to SARS?
    Eddie Y K Ng
    School of Mechanical and Production Engineering, College of Engineering, Nanyang Technical University, Singapore 639798, Singapore
    Med Phys 32:93-7. 2005
    ..It is believed that IR cameras can potentially be used to detect subjects with fever, the cardinal symptom of SARS, and avian influenza...
  27. ncbi [Operative neurosurgery: personal view and historical backgrounds. 6. Positioning, instruments]
    Yasuhiro Yonekawa
    University of Zurich, Switzerland
    No Shinkei Geka 38:381-96. 2010
    ..around the medial root of the mastoid process (thickness of the bone and small amount of soft tissue) is of cardinal importance and prevention of excessive flexion (with the one-finger breadth between the chin and its underlying ..
  28. ncbi Cholinoceptor-mediated control of catecholamine release from chromaffin cells in the American eel, Anguilla rostrata
    S G Reid
    Department of Biology, University of Ottawa, Ontario, Canada
    J Comp Physiol B 165:464-70. 1995
    ..from chromaffin cells in the American eel, Anguilla rostrata, was assessed using a saline-perfused posterior cardinal vein preparation. Direct membrane depolarization with 60 mmol...
  29. ncbi [Terminal heart failure; therapeutic strategies. Drug therapy in cases of absence of possibility of heart transplantation: dobutamine therapy, aspects of compassion?]
    G Roul
    Service de cardiologie, Hopital de Hautepierre, Strasbourg
    Arch Mal Coeur Vaiss 89:27-32. 1996
    ..Nevertheless, the abnormalities of cardiovascular function remain the cardinal problem. The treatment which we use aims to correct them...
  30. doi V2R mutations and nephrogenic diabetes insipidus
    Daniel G Bichet
    Canada Research Chair in Genetics of Renal Diseases, Groupe d étude des protéines membranaires, Montreal, Quebec, Canada
    Prog Mol Biol Transl Sci 89:15-29. 2009
    ..Polyuria, with hyposthenuria, and polydipsia are the cardinal clinical manifestations of the disease...
  31. ncbi Vaginal axis after abdominal, vaginal and laparoscopic hysterectomy: a preliminary study with perineal ultrasonography using contrast medium
    H S Virtanen
    Department of Obstetrics and Gynecology, University Central Hospital of Turku, Finland
    Int Urogynecol J Pelvic Floor Dysfunct 7:196-201; discussion 201-2. 1996
    ..Transabdominal and vaginal hysterectomies were performed in the classic manner, i.e. the round as well as cardinal and sacrouterine ligaments were attached to the vaginal vault, followed by peritonealization...
  32. ncbi Clinical aspects and management of hereditary non-polyposis colorectal cancer (HNPCC)
    L Bertario
    Divisione Chirurgia Apparato Digerente, Istituto Nazionale dei Tumori, Milano, Italy
    Tumori 82:117-21. 1996
    ..Important cardinal features are: 1) prevalent proximal location of cancers (above splenic flexure); 2) multiple synchronous or ..
  33. doi Modelling growth of Penicillium expansum and Aspergillus niger at constant and fluctuating temperature conditions
    Maria Gougouli
    Laboratory of Food Microbiology and Hygiene, Department of Food Science and Technology, School of Agriculture, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Int J Food Microbiol 140:254-62. 2010
    ..mu) and (apparent) lag time (lambda) of the mycelium growth were modelled as a function of temperature using a Cardinal Model with Inflection (CMI)...
  34. ncbi [Joubert syndrome: a report of 5 cases]
    B Calleja-Pérez
    Servicio de Neurología Pediátrica, Hospital Infantil La Paz, Madrid, Espana
    Rev Neurol 26:548-50. 1998
    ..To review clinical features, radiological findings and prognosis in Joubert syndrome...
  35. ncbi [Renal hemodynamics and proteinuria in chronic glomerulonephritis treated with beta-receptor blockers or ace inhibitors]
    C M Erley
    Abteilung Innere Medizin III, Medizinischen Universitätsklinik der Eberhard Karls Universität Tübingen
    Dtsch Med Wochenschr 122:953-8. 1997
    ..with chronic glomerular nephropathy associated arterial hypertension and proteinuria are considered to be cardinal risk factors in the progressive deterioration of renal function...
  36. ncbi Ultrastructural distinction of basaloid-squamous carcinoma and adenoid cystic carcinoma
    K Hewan Lowe
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Ultrastruct Pathol 19:371-81. 1995
    ..The cardinal diagnostic criteria are the presence of basaloid cells arranged in lobules or cords and a squamous component...
  37. ncbi Wavelength-dependent effects of light on magnetic compass orientation in Drosophila melanogaster
    J B Phillips
    Department of Biology, Indiana University, Bloomington 47405
    J Comp Physiol A 172:303-8. 1993
    ..were trained in the ambient magnetic field to a horizontal gradient of 365 nm light emanating from one of the 4 cardinal compass directions and were subsequently tested in a visually-symmetrical, radial 8-arm maze in which the ..
  38. ncbi Cardinal points and image-object magnification with an accommodative lens implant (1 CU)
    Achim Langenbucher
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Ophthalmic Physiol Opt 23:61-70. 2003
    A simple mathematical method for the determination of the cardinal points of pseudophakic eyes after implantation of an accommodative intraocular lens [posterior chamber intraocular lenses (PCIOL)] is presented...
  39. ncbi Apical vault repair, the cornerstone or pelvic vault reconstruction
    J W Ross
    Center for Reproductive Medicine and Laparoscopic Surgery, Salinas, California 93901, USA
    Int Urogynecol J Pelvic Floor Dysfunct 8:146-52. 1997
    ..The incorporation of pubocervical fascia, uterosacral-cardinal ligament and the rectovaginal fascia provides a strong anchor for the vaginal apex...
  40. ncbi [Alzheimer's disease: new prospects in therapy and applied experimental models]
    Adriana M Kubis
    Zakład Biotechnologii Białek, Wydział Biotechnologii, Uniwersytet Wrocławski, ul Tamka 2, 50 137 Wrocław
    Postepy Hig Med Dosw (Online) 62:372-92. 2008
    ..The gradual and irreversible disturbances in homeostasis are characteristic features of the disease process. The cardinal features of AD include the formation of extracellular protein deposits in the brain that consist predominantly of ..
  41. ncbi Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice
    Agustin Rodriguez
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    Acta Neuropathol 112:573-85. 2006
    Spongiform change is a cardinal feature in transmissible spongiform encephalopathies, including Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE)...
  42. doi Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, CIBERNED, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    J Neural Transm (Vienna) 118:821-39. 2011
    ..This review presents cardinal observations at very early stages of PD and provides personal experience based on the study of a consecutive ..
  43. ncbi Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    A Morishima
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Endocrinol Metab 80:3689-98. 1995
    ..The 28-yr-old XX proband, followed since infancy, exhibited the cardinal features of the aromatase deficiency syndrome as recently defined...
  44. ncbi An analysis of orientation and ocular dominance patterns in the visual cortex of cats and ferrets
    T Muller
    Department of Computer Science, TU Berlin, Germany
    Neural Comput 12:2573-95. 2000
    ..Also, we find the well-known overrepresentation of cardinal versus oblique orientations in young ferrets (Chapman & Bonhoeffer, 1998; Coppola, White, Fitzpatrick, & ..
  45. ncbi [Operative neurosurgery: personal view and historical backgrounds. (5) Meningioma]
    Yasuhiro Yonekawa
    University of Zurich
    No Shinkei Geka 37:71-90. 2009
    ..following comments are to be emphasized: Appropriate approach and interruption of blood supply are of cardinal importance in surgical management of meningiomas...
  46. ncbi Skin diseases associated with the cosmetic use of bleaching products in women from Dakar, Senegal
    A Mahe
    Department of Dermatology, Institut d Hygiene Sociale, Dakar, Senegal
    Br J Dermatol 148:493-500. 2003
    ..The cosmetic use of bleaching products is considered a common practice in dark-skinned women from sub-Saharan Africa. However, there are few studies on this subject...
  47. ncbi Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy
    A L Benabid
    Department of Neurosurgery, CHU A Michallon, Grenoble, France
    J Neurol 248:III37-47. 2001
    ..STN appears to be a target of major interest, able to control the three cardinal symptoms and to allow the decrease or suppression of levodopa treatment, which then also suppresses levodopa ..
  48. ncbi Dermatosis papulosa nigra in Dakar, Senegal
    Suzanne Oumou Niang
    Department of Dermatology, Le Dantec Hospital, Dakar, Senegal
    Int J Dermatol 46:45-7. 2007
    ..Its benign character has meant that very few studies have been performed. In Senegal, no investigation has been carried out to date...
  49. ncbi [Physical handicapped, economic practices and matrimonial strategies in Senegal]
    D Fassin
    IFEA, ORSTOM, Quito, Ecuador, South America
    Soc Sci Med 32:267-72. 1991
    ..From a series of in-depth interviews conducted in handicapped families of the suburbs of Dakar, two aspects are analyzed: the economic role of the handicapped, through the circulation of the product of his ..
  50. ncbi Silent ischaemia: an update on current concepts
    J J Glazier
    Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Cardiol 46:461-9. 1991
    Angina pectoris is the cardinal symptom of coronary heart disease and is a symptom with which physicians are very familiar...
  51. ncbi Effect of metabolic acidosis on the growth hormone/IGF-I endocrine axis in skeletal growth centers
    J Green
    Departments of Nephrology, Rambam Medical Center, The B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Kidney Int 57:2258-67. 2000
    Chronic metabolic acidosis (CMA) adversely affects bone metabolism and skeletal growth. Given the cardinal role played by the local growth hormone (GH)/insulin-like growth factor-I (IGF-I) in promoting cell proliferation and ..
  52. ncbi [Self-treatment of fever in the northern district of Dakar, Senegal]
    P Ndiaye
    Service de médecine préventive et Santé publique, UCAD Dakar, BP 16 390, Dakar Fann, Senegal
    Med Trop (Mars) 66:74-8. 2006
    Malaria is assimilated with its cardinal symptom, i.e., fever. Treatment of fever with antimalarial drugs is crucial to the prevention of malaria-related death in Senegal...
  53. ncbi Validation of a chromatography data analysis software
    A Felinger
    Department of Analytical Chemistry, , Hungary
    J Chromatogr A 913:221-31. 2001
    The performance of chromatography data analysis software packages is of cardinal importance when the precision and the accuracy of a chromatographic system are evaluated...
  54. ncbi Overview and clinical presentation of generalized anxiety disorder
    K Rickels
    Section of Mood and Anxiety Disorders, Department of Psychiatry, University of Pennsylvania School of Meidicine, Philadelphia, USA
    Psychiatr Clin North Am 24:1-17. 2001
    ..The cardinal symptoms of GAD commonly overlap with those of social phobia, particularly if the social phobia is more general ..
  55. ncbi [Reactivity of the arterial wall to atherogenic stimuli]
    J Larrue
    INSERM U8 de recherches de cardiologie, Pessac
    Arch Mal Coeur Vaiss 84:1635-43. 1991
    ..The rupture of parietal homeostasis is discussed with reference to some experimental models in terms of intimal cellular recruitment and formation of foam cells which are the cardinal points of the initial pathogenic process.
  56. ncbi Changes in extracellular matrix proteins in the cardinal ligaments of post-menopausal women with or without prolapse: a computerized immunohistomorphometric analysis
    Ayman A A Ewies
    Leicester and Warwick Medical School, UK
    Hum Reprod 18:2189-95. 2003
    ..The precise mechanism of uterine prolapse is poorly understood. There is evidence to suggest that abnormalities of connective tissue structure or its repair mechanism may predispose women to prolapse...
  57. ncbi [Penetrating wound of the abdomen. Profile of the suffering patient at Dakar teaching hospital]
    M Dieng
    Clinique Chirurgicale, CHU Aristide Le Dantec, Dakar
    Dakar Med 51:22-6. 2006
    ..The purpose of this study was to make a descriptive analysis of the epidemiological data on the patient suffering from a penetrating wound of the abdomen...
  58. ncbi [Allergy to latex gloves among healthcare workers in Dakar]
    F Ly
    Service de Dermatologie, IST de l Institut d Hygiène Social, Dakar, Senegal
    Ann Dermatol Venereol 133:971-4. 2006
    The prevalence of latex allergy is high (to 17%) among groups at risk such healthcare workers. Our aim was to determine the prevalence and severity of allergy to latex gloves among health workers in Dakar.
  59. ncbi Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms
    A Sjoholm
    Department of Molecular Medicine, Rolf Luft Center for Diabetes Research, Karolinska Institute, Stockholm, Sweden
    Diabetes 46:1141-7. 1997
    Glucose is a cardinal secretory and mitogenic stimulus for the insulin-producing pancreatic beta-cell both in vitro and in vivo, but the mechanisms by which the sugar acts mitogenically remain largely elusive...
  60. ncbi Primary prevention with cotrimoxazole for HIV-1-infected adults: results of the pilot study in Dakar, Senegal
    M Maynart
    INSERM U88, Paris, France
    J Acquir Immune Defic Syndr 26:130-6. 2001
    ..To assess the efficacy and tolerance of chemoprophylaxis with cotrimoxazole compared with placebo among HIV-1-infected adults...
  61. ncbi [The syndrome of "muscle deconditioning" in chronic cardiac insufficiency]
    J G Kayanakis
    Clinique cardiologique Paulmy, Bayonne
    Arch Mal Coeur Vaiss 82:1455-8. 1989
    Fatigue, that cardinal symptom of heart failure, expresses muscle deconditioning and is becoming the main complaint of our patients...
  62. ncbi Risk factors for negative sputum acid-fast bacilli smears in pulmonary tuberculosis: results from Dakar, Senegal, a city with low HIV seroprevalence
    B Samb
    INSERM U13 IMEA, Paris, France
    Int J Tuberc Lung Dis 3:330-6. 1999
    Two teaching hospitals in Dakar, Senegal, a West African country with a low prevalence of human immunodeficiency virus (HIV) infection.
  63. ncbi Circulating chemoattractants RANTES, negatively related to endogenous androgens, and MCP-1 are differentially suppressed by hormone therapy and raloxifene
    George E Christodoulakos
    2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece
    Atherosclerosis 193:142-50. 2007
    The cardinal role of chronic inflammation in the development of atherosclerosis is increasingly being recognized. Estrogens may prevent the evolution of atherosclerosis by suppressing immune response...
  64. ncbi Inner connections within domain of dementia praecox: role of supervisory mental processes in schizophrenia
    P F Liddle
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Eur Arch Psychiatry Clin Neurosci 245:210-5. 1995
    ..Neuropsychological studies reveal that the three cardinal dimensions reflect disorder of the supervisory mental processes responsible for initiation, selection and ..
  65. ncbi Schizotypy and leadership: a contrasting model for deficit symptoms, and a possible therapeutic role for sex hormones
    A G Alias
    Chester Mental Health Center, Illinois 62233, USA
    Med Hypotheses 54:537-52. 2000
    ..to shift attention, poor working memory, passivity, ambivalence, anhedonia, and impaired motor coordination are cardinal features of schizophrenia but, unlike delusions and hallucinations, they are related more to negative/deficit ..
  66. ncbi The intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a new rodent model to test palliative and neuroprotective agents for Parkinson's disease
    Rui D S Prediger
    Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, 88049 900, Florianopolis, SC, Brazil
    Curr Pharm Des 17:489-507. 2011
    ..Classically, PD is considered to be a motor system disease and its diagnosis is based on the presence of a set of cardinal motor signs that are consequence of a pronounced death of dopaminergic neurons in the substantia nigra pars ..
  67. ncbi [Expression of androgen receptor in the vaginal wall and cardinal ligament of patients with pelvic organ prolapse]
    Yi song Chen
    Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
    Zhonghua Yi Xue Za Zhi 88:2920-3. 2008
    ..To evaluate the role of androgen and its receptor in the pathogenesis of prolapse of pelvic floor...
  68. ncbi Cardinal vein isomerism: an embryological hypothesis to explain a persistent left superior vena cava draining into the roof of the left atrium in the absence of coronary sinus and atrial septal defect
    Fabio Miraldi
    Institute of Cardiac Surgery, La Sapienza University, Rome, Italy
    Cardiovasc Pathol 11:149-52. 2002
    ..This anomaly has been explained with the persistence of the left superior cardinal vein...
  69. pmc Altered motor control patterns in whiplash and chronic neck pain
    Astrid Woodhouse
    Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7489 Trondheim, Norway
    BMC Musculoskelet Disord 9:90. 2008
    ....
  70. doi [Neuroleptic malignant syndrome and atypical antipsychotics: a brief review]
    S Khaldi
    Encephale 34:618-24. 2008
    ..118 (1960) 145-152] described the "syndrome akinétique hypertonique"(hypertonic akinetic syndrome) and its cardinal symptoms: hyperthermia, extrapyramidal symptoms, altered mental status and autonomic dysfunctions...
  71. ncbi [Evaluation of the need for periodontal treatment in prisons near Dakar, Senegal]
    M Diouf
    Service de santé publique dentaire, Universite Cheikh Anta Diop, Dakar, Senegal
    Med Trop (Mars) 69:587-90. 2009
    ..This study focused on the prison population that is characterized by poor living conditions and malnutrition. The aim of study was to assess the need for periodontal care in prisoners serving time in the Dakar region of Senegal.
  72. ncbi The use of legume trap crops for control of Striga hermonthica (Del.) Benth. in sorghum (Sorghum bicolor L. Moench) in northern Nigeria
    Nuhu A Gworgwor
    Department of Crop Science, Faculty of Agriculture, University of Maiduguri P M B 1069, Maiduguri, Borno State, Nigeria
    Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet 67:421-30. 2002
    ..Ex-Dakar variety of groundnut was used for the sorghum-groundnut trial, while a creamed brown eyed local bambara groundnut ..
  73. ncbi Desensitisation of chromaffin cell nicotinic receptors does not impede catecholamine secretion during acute hypoxia in rainbow trout (Oncorhynchus mykiss)
    K N Lapner
    Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Exp Biol 203:1589-97. 2000
    ..trout (Oncorhynchus mykiss) in vivo using chronically cannulated fish and in situ using a perfused posterior cardinal vein preparation (i) to characterise the desensitisation of chromaffin cell nicotinic receptors and (ii) to ..
  74. doi [Perceptions and motivations of public sector physicians in Dakar (Senegal)]
    Papa Ndiaye
    Service de médecine préventive et Santé publique, Université Cheikh Anta Diop UCAD, BP 16390, Dakar Fann Senegal
    Sante 17:223-8. 2007
    To guide the human resources department within the Ministry of Health to optimize their capacities and skills, this study sought to evaluate perceptions and motivations among public sector physicians in the Dakar region, in Senegal.
  75. ncbi [Crusted (Norwegian) scabies in Dakar (Senegal)]
    B Ndiaye
    Laboratoire de Parasitologie-Mycologie, , rue de la Chine, 75970 Paris Cedex 20, France
    Sante 9:243-8. 1999
    Between January 1993 and June 1997, 30 patients with crusted scabies were seen at the dermatological clinic in Dakar (Senegal). Seventeen of these patients were male and 13 were female...
  76. ncbi Taste bud form and distribution on lips and in the oropharyngeal cavity of cardinal fish species (Apogonidae, Teleostei), with remarks on their dentition
    Lev Fishelson
    Department of Zoology and Laboratory of Electronmicroscopy, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Morphol 259:316-27. 2004
    ..of taste buds (TB) on the lips and in the oropharyngeal cavity were compared by means of SEM in 11 species of cardinal fishes (Apogonidae) belonging to five genera...
  77. ncbi Comparative bioavailability of three ibuprofen formulations in healthy human volunteers
    G D Mendes
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas UNICAMP, SP, Brazil
    Int J Clin Pharmacol Ther 46:309-18. 2008
    ..the bioequivalence of three ibuprofen formulations (Test formulation: ibuprofen (400 mg capsule) manufactured by Cardinal Health Brasil 402 Ltda. (Sorocaba, Brazil) and licensed to Boehringer Ingelheim do Brasil Quim. e Farm. Ltda...
  78. pmc Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists
    Nissar A Darmani
    Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA
    Brain Res 1214:58-72. 2008
    Substance P (SP) is thought to play a cardinal role in emesis via the activation of central tachykinin NK1 receptors during the delayed phase of vomiting produced by chemotherapeutics...
  79. pmc Highly focused anopheline breeding sites and malaria transmission in Dakar
    Vanessa Machault
    Unité d entomologie médicale, Equipe 7 Maladies Emergentes et Moustiques, Institut de Medecine Tropicale du Service de Sante des Armees, Allée du Médecin Colonel Jamot, Parc du Pharo, 13262 Marseille cedex 07, France
    Malar J 8:138. 2009
    Urbanization has a great impact on the composition of the vector system and malaria transmission dynamics. In Dakar, some malaria cases are autochthonous but parasite rates and incidences of clinical malaria attacks have been recorded at ..
  80. pmc The role of the medial longitudinal fasciculus in horizontal gaze: tests of current hypotheses for saccade-vergence interactions
    Athena L Chen
    Department of Neurology, Veterans Affairs Medical Center and Case Western Reserve University, Cleveland, OH 44106 5040, USA
    Exp Brain Res 208:335-43. 2011
    ..The brainstem medial longitudinal fasciculus (MLF) plays a cardinal role in ensuring that horizontal saccades between equidistant targets are tightly yoked...
  81. ncbi The effects of acute hypoxia on chemically or neuronally induced catecholamine secretion in rainbow trout (Oncorhynchus mykiss) in situ and in vivo
    S F Perry
    Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Exp Biol 203:1487-95. 2000
    ..hypoxia on catecholamine secretion in rainbow trout (Oncorhynchus mykiss) were assessed in situ, using a perfused cardinal vein preparation, and in vivo, using chronically cannulated fish...
  82. ncbi [Mesolimbic and mesocortical pathways in Parkinson disease]
    Masayuki Yokochi
    Department of Neurology, Tokyo Metropolitan HMTC Ebara Hospital, 4 5 10 Higashiyukigaya, Ota ku, Tokyo 145 0065, Japan
    Brain Nerve 59:943-51. 2007
    ..Akinesia is composed of two cardinal elements "bradykinesia" and "hypokinesia"...
  83. doi Onset of symptom resolution in adults with acute bacterial rhinosinusitis treated with a single dose of azithromycin extended release compared with 10 days of levofloxacin: a retrospective analysis of a randomized, double-blind, double-dummy trial
    Bradley F Marple
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Clin Ther 29:2690-8. 2007
    ..The speed with which patients experience resolution of ABRS symptoms has not been reported...
  84. doi Lichens as biomonitors of air quality around a diamond mine, northwest territories, Canada
    M A Naeth
    Dep of Renewable Resources, Room 751 General Services Building, Univ of Alberta, Edmonton, Alberta, Canada T6G 2H1
    J Environ Qual 37:1675-84. 2008
    ..Eight sample sites were located immediately adjacent to a diamond mine, one in each cardinal and ordinal direction, and six sample sites each were located 30 and 60 km from the mine (cardinal, NE, and SE)...
  85. ncbi [Adult purulent meningitis caused by Streptococcus pneumoniae in Dakar, Senegal]
    N M Manga
    Clinique des Maladies Infectieuses et Tropicales, CHNU Fann, Dakar
    Med Trop (Mars) 68:625-8. 2008
    ..pneumoniae in adult patients hospitalized in the infectious diseases clinic of the Fann University Hospital in Dakar, Senegal from 1995 to 2004. A total of 73 cases of pneumococcal meningitis were recorded during the study period...
  86. ncbi Use of isolated populations in the study of a human obesity syndrome, the Bardet-Biedl syndrome
    Val C Sheffield
    Department of Pediatrics, Division of Medical Genetics, Howard Hughes Medical Institute, University of Iowa, 4181 MERF, Iowa City, IA 52242, USA
    Pediatr Res 55:908-11. 2004
    Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder with the cardinal features of obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay...
  87. ncbi Pain attacks in non-complicated and complicated gallstone disease have a characteristic pattern and are accompanied by dyspepsia in most patients: the results of a prospective study
    Tewelde Berhane
    Department of Surgery, Rogaland Central Hospital, Stavanger, Norway
    Scand J Gastroenterol 41:93-101. 2006
    The cardinal indication for surgical treatment of gallstones is pain attacks. However, following cholecystectomy, 20% of patients remain symptomatic...
  88. ncbi Benzodiazepines prescription in Dakar: a study about prescribing habits and knowledge in general practitioners, neurologists and psychiatrists
    Amadou Moctar Dieye
    Laboratoire de Pharmacologie et de Physiologie, Faculte de Medecine, de Pharmacie et d Odonto Stomatologie, Universite Cheikh Anta Diop, BP5005, Dakar, Senegal
    Fundam Clin Pharmacol 20:235-8. 2006
    ..Specialist doctors work in two Dakar university hospitals and generalists in the 11 health centres in Dakar...
  89. ncbi Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats
    Daniela Pellegrino
    Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nucl Med 48:1147-53. 2007
    Degeneration of dopaminergic neurons of the substantia nigra pars compacta is a cardinal feature of Parkinson's disease (PD)...
  90. ncbi Epidemiologic, clinical, and therapeutic features of acne in Dakar, Senegal
    Assane Kane
    Department of Dermatology, Cheikh Anta Diop University, A Le Dantec Hospital, Dakar, Senegal
    Int J Dermatol 46:36-8. 2007
    ..The etiologic factors are not always the same, and the treatments proposed are not always well tolerated in black individuals...
  91. ncbi How dietary restriction catalyzed the evolution of the human brain: An exposition of the nutritional neurotrophic neoteny theory
    Nūn Amen-Ra
    Amenta Press Inc, P O Box 236, Damascus, MD 20872, USA
    Med Hypotheses 69:1147-53. 2007
    ..These cardinal phenotypic features, termed the Quadripartite Complex, were selected for their adaptiveness amidst the ..
  92. doi Cervical pachymeningeal hypertrophy as the initial and cardinal manifestation of mucopolysaccharidosis type I in monozygotic twins with a novel mutation in the alpha-L-iduronidase gene
    Yutaka Furukawa
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Neurol Sci 302:121-5. 2011
    ..At age 24, they both developed cervical myelopathy as a cardinal manifestation...
  93. ncbi Hypopnea, a floating metric: implications for prevalence, morbidity estimates, and case finding
    S Redline
    Case Western Reserve University, Cleveland VA Sleep Disorders Center, Cleveland Veterans Affairs Medical Center, Ohio 44106, USA
    Sleep 20:1209-17. 1997
    ..Its popularity as a cardinal disease-defining measure, however, may not be justified given that standardized criteria do not exist for ..
  94. ncbi [Skin disease in Koranic schools in Dakar (Senegal)]
    Suzanne Oumou Niang
    Service de Dermatologie, Hopital Le Dantec Dakar
    Mali Med 23:5-9. 2008
    The koranic schools are in poor socio-economical conditions in Dakar and skin diseases are common in these conditions. The goal of our descriptive study was to determine the prevalence of skin diseases occurring in these situations...
  95. pmc Re-emergent tremor of Parkinson's disease
    J Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurol Neurosurg Psychiatry 67:646-50. 1999
    To characterise postural tremors in patients with Parkinson's disease. Rest tremor is a well recognised cardinal symptom of Parkinson's disease, but postural tremors associated with the disease may cause more disability than the more ..
  96. ncbi [Prospective study of sexually transmitted infections in Dakar, Senegal]
    F Ly
    Med Trop (Mars) 66:64-8. 2006
    ..Most patients were Wolof people living in or around Dakar and working in the trades sector (shopkeeper, artists, tailors, drivers, and seamen)...
  97. ncbi The development of scales to measure the experience of self-participation in sleep
    L Weinstein
    City University of New York, New York
    Sleep 11:437-47. 1988
    Recent literature suggests that how the self is represented is a cardinal aspect of the dream experience...
  98. ncbi Headache in brain tumor: a cross-sectional study
    N Suwanwela
    Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Headache 34:435-8. 1994
    Headache is one of the cardinal features of intracranial neoplasm. However, there is little published information on the prevalence and clinical profiles of headache in patients with brain tumor...
  99. ncbi Innervation density of the base of the palm
    D S Ruch
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157 1070, USA
    J Hand Surg Am 24:392-7. 1999
    ..An incision in the long/ring finger web space 2 cm proximal to Kaplan's cardinal line should result in injury to fewer nerves and reduce the incidence of painful neuromas during open carpal ..
  100. ncbi Sesamoiditis of the index finger presenting as acute suppurative flexor tenosynovitis
    C J Lang
    Department of Orthopaedic Surgery, Georgia Baptist Medical Center, Atlanta, USA
    J Hand Surg Am 24:1327-30. 1999
    ..We report a patient who presented with Kanavel's 4 cardinal signs of acute suppurative tenosynovitis who was subsequently found to have an acute sesamoiditis of the index ..
  101. ncbi Expression of Hox 2.1 protein in restricted populations of neural crest cells and pharyngeal ectoderm
    S C Kuratani
    V and M McLean Biochemistry Department, Baylor College of Medicine, Houston, Texas 77030
    Dev Dyn 195:15-28. 1992
    ..1 protein. (2) At 9.5 d.p.c., presumptive crest cells lateral to the cephalic cardinal vein and within pharyngeal arches 4 and 6 are immunoreactive for alpha Hox 2.1a...

Research Grants69

  1. GEOFFREY SCOTT GOTTLIEB; Fiscal Year: 2014
    ..will build on a strong ongoing collaboration between the University of Washington and the Universite Cheikh Anta Diop de Dakar, Senegal to further our understanding and provide evidence-based ART and care for HIV-2 infected people.
  2. Robert L Murphy; Fiscal Year: 2016
    ..Site (CC-CRS) all located in Chicago, an international site at Fann Hospital/Universite Cheikh Anta Diop in Dakar, Senegal (SN-CRS), and the Peabody Health Center, a member of the Black Clinical Research Consortium, located in ..
  3. Northwestern University Clinical Trial Unit
    Robert L Murphy; Fiscal Year: 2011
    ..Site (CC-CRS) all located in Chicago, an international site at Fann Hospital/Universite Cheikh Anta Diop in Dakar, Senegal (SN-CRS), and the Peabody Health Center, a member of the Black Clinical Research Consortium, located in ..
  4. PET STUDY OF BIOCHEMISTRY AND METABOLISM OF THE CNS
    Kirk A Frey; Fiscal Year: 2012
    ..These cardinal PD features are all initially responsive to dopamine replacement therapy, and have been investigated intensively ..
  5. Dopaminergic Modulation Of Cognitive Aspects Of Skill Acquisition In PD
    Brenda Hanna Pladdy; Fiscal Year: 2010
    Parkinson disease (PD) is characterized by cardinal symptoms of bradykinesia, rigidity, and resting tremor considered reflective of dopaminergic (DA) neuronal loss in the nigrostriatal tract...
  6. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2012
    ..to nursing homes and caregiver strain are influenced most by the psychiatric comorbidities of PD, not the cardinal motor symptoms of PD...
  7. Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic Syndrome
    Robert S Schwartz; Fiscal Year: 2010
    ..Metabolic Syndrome (MS) is a collection of inter-related metabolic abnormalities with the cardinal feature being insulin resistance (IR)...
  8. Genome-Wide Association Scan of Polycystic Ovary Syndrome Phenotypes
    Andrea Dunaif; Fiscal Year: 2010
    ..Indeed, male as well as female first-degree relatives have reproductive and metabolic phenotypes. Further, the cardinal reproductive feature of the syndrome, hyperandrogenemia, appears to play a direct role in the etiology of the ..
  9. Beverley Greenwood-Van Meerveld; Fiscal Year: 2016
    ..Employing validated rodent models, that exhibit the cardinal aspects of IBS, namely anxiety accompanied by colonic hypersensitivity induced by either i) direct application of ..
  10. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012
    ..Previous work has established that central administration of inflammatory cytokines can recreate all of the cardinal features of cachexia...
  11. Alcohol increases tight junction permeability &disrupts translocation of ZO-1
    Samantha Simet; Fiscal Year: 2012
    ..Airway "leak" is a cardinal feature of airway diseases such as bronchitis and asthma...
  12. LEONARD IRA ZON; Fiscal Year: 2015
    ..relevant to the hematopoietic system, where engineering gene defects into mouse strains has failed to phenocopy cardinal features of diseases like Fanconi anemia and Down Syndrome...
  13. Robert B Felder; Fiscal Year: 2016
    ..Overactivity of the sympathetic nervous system is a cardinal manifestation of the heart failure syndrome, and a strong predictor of morbidity and mortality...
  14. YVETTE FRANCE TACHE; Fiscal Year: 2015
    ..applicant): Abstract Irritable bowel syndrome (IBS) is a stress-sensitive disorder for which abdominal pain is a cardinal symptom that drives illness severity more than other motor symptoms...
  15. Corrine K Welt; Fiscal Year: 2014
    ..The disorder is defined by its cardinal features: irregular menstrual cycles, hyperandrogenism and a polycystic ovary pattern on ultrasound...
  16. Robert B Felder; Fiscal Year: 2014
    ..Overactivity of the sympathetic nervous system (SNS) is a cardinal manifestation of the heart failure syndrome, and a strong predictor of morbidity and mortality...
  17. Natalie Russo; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Sensory atypicalities represent a cardinal feature of Autism Spectrum Disorders (ASD) and have been established as the source of much behavioral aggression, frustration, and functional impairment over ..
  18. Patrice G Guyenet; Fiscal Year: 2016
    ..The cardinal signs of CCHS are day time hypoventilation, total sleep apnea and loss of breathing stimulation by CO2...
  19. James N Baraniuk; Fiscal Year: 2016
    ..One of the cardinal clinical features of FM, GWI and CFS is "exertional exhaustion"...
  20. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Lung alveolar epithelial cell (AEC) injury and apoptosis are cardinal features of ALI;an improved understanding of this process in T/HS- induced lung injury is needed in order to ..
  21. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Decreased insulin sensitivity is a cardinal feature of various pathological conditions such as type 2 diabetes and hypertension...
  22. Robert P Lane; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The genome is the cardinal instrument of development that encodes the genetic parts and programs of an organism...
  23. AN HTS ASSAY FOR INHIBITORS OF C. DIFFICLE TOXINS
    David B Haslam; Fiscal Year: 2013
    ..The cardinal virulence factors of C. difficile are a pair of closely related toxins A and B (also known as TcdA and TcdB)...
  24. Central and Peripheral Autonomic Responses in Irritable Bowel Syndrome
    Kirsten Tillisch; Fiscal Year: 2010
    ..The cardinal IBS symptoms of pain, discomfort and altered bowel habits likely arise from a combination of stress modulated ..
  25. Yuan Zhuang; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): E2A/HEB MEDIATED TRANSCRIPTIONAL REGULATION IN T CELL DEVELOPMENT Abstract A cardinal feature of T lymphocytes is their ability to provide antigen specific immune responses to foreign pathogens while ..
  26. A Structural &Functional Study of the Upper Airway in Adolescent Girls with PCOS
    David M Wootton; Fiscal Year: 2013
    ..Insulin resistance is a cardinal feature of PCOS given that the majority of women are overweight or obese...
  27. JONATHAN D CHERNOFF; Fiscal Year: 2016
    ..The proposed studies will not only increase our understanding of cardinal cancer-relevant signaling pathways, but could establish the Paks as suitable targets for therapeutic intervention ..
  28. TRPC-mediated calcium signaling in podocytes
    Anna Greka; Fiscal Year: 2012
    PROJECT SUMMARY Proteinuria is a major health-care problem, not only as a cardinal sign and prognostic marker of kidney disease, but also importantly, as an independent risk factor for cardiovascular morbidity and mortality...
  29. Charles B Nemeroff; Fiscal Year: 2016
    ..Although the majority of trauma victims experience the cardinal symptoms of re-experiencing, avoidance and hyperarousal, for the large majority of such individuals, these ..
  30. Kerry J Ressler; Fiscal Year: 2016
    ..Although the majority of trauma victims experience the cardinal symptoms of re-experiencing, avoidance and hyperarousal, for the large majority of such individuals, these ..
  31. Harvey Checkoway; Fiscal Year: 2014
    ..We will conduct standardized neurological examinations to determine the prevalence and severity of the cardinal signs and symptoms of parkinsonism among 600 retired women previously employed in cotton textile factories who ..
  32. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..factor in type II epithelial cells causes enlargement of the alveolar air spaces and lung inflammation, which are cardinal features of emphysema...
  33. Age related Cognitive Loss in Mumbai, India
    Dushyant P Purohit; Fiscal Year: 2010
    ..data suggest, in the course of normal aging the inhabitants of Mumbai show a decreased tendency to develop these cardinal neuropathologic features of Alzheimer's disease...
  34. Pankaj J Pasricha; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Chronic pancreatitis remains a common and challenging clinical syndrome. Its cardinal feature, pain, has been difficult to treat effectively despite a multitude of empirical therapeutic approaches...
  35. The role of SIRT1/FOXO4 pathway in podocyte apoptosis of diabetes mellitus
    PETER YENLUNG CHUANG; Fiscal Year: 2013
    ..Recent studies revealed that loss of kidney podocytes is an early cardinal feature that contributes to the development and progression of DN;however, the underlying mechanism of podocyte ..
  36. Keiko Hirose; Fiscal Year: 2016
    ..Additional studies will examine the involvement of the cardinal scavenger receptor, CD36, in the phagocytosis of injured hair cells...
  37. Paolo Rinaudo; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Stress in utero or during the early post natal period plays a cardinal role in shaping future health...
  38. Zhenqi Liu; Fiscal Year: 2014
    ..Insulin resistance and endothelial dysfunction are two cardinal features of T2DM...
  39. Neurobiological Correlates of Language Dysfunction in autism Spectrum Disorders
    Jeffrey D Lewine; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Language dysfunction is one of the cardinal characteristics of the autism spectrum disorders...
  40. Role of NADPH oxidase 1-derived ROS in the pathogenesis of Parkinson's disease
    Yoon Seong Kim; Fiscal Year: 2012
    ..This suggests that two cardinal factors, mitochondrial dysfunction and oxidative stress, implicated in the PD pathogenesis may link each other ..
  41. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..prominent topics in the field of cancer biology is that tumour-initiating cells, which phenotypically mimic the cardinal properties of stem cells, are responsible for the origin and maintenance of solid tissue malignancies...
  42. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    John H Streiff; Fiscal Year: 2010
    ..A cardinal rule in vascular physiology is that 2x plasma Na+ concentration equates with normal plasma osmolality and sets ..
  43. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    Erik Schwiebert; Fiscal Year: 2009
    ..A cardinal rule in vascular physiology is that 2 x plasma Na+ concentration equates with normal plasma osmolality and sets ..
  44. Yvonne M W Janssen-Heininger; Fiscal Year: 2016
    ..The pro-fibrotic cytokine, transforming growth factor beta-1 (TGF-[unreadable]1) plays a cardinal role in fibrogenesis...
  45. Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension
    ROMER ANDRES GONZALEZ-VILLALOBOS; Fiscal Year: 2013
    ..homeostasis and blood pressure regulation, it is likely that an augmented intrarenal Ang II generation is of cardinal importance for the development of hypertension and renal damage but this has not been determined...
  46. Disease Mechanisms in ARVC
    Jeffrey E Saffitz; Fiscal Year: 2013
    ..A cardinal feature of ARVC is a very high incidence of ventricular arrhythmias which occur early in the natural history of ..
  47. Developing cell lines from clock neurons in Drosophila
    Paul E Hardin; Fiscal Year: 2013
    ..In Specific Aim 2 we will determine whether these cell lines display the cardinal clock properties of self-sustained ~24h periodicity, phase shifting by environmental cues, and periods that are ..
  48. Hugh C Hemmings; Fiscal Year: 2016
    ..to explain how any anesthetic produces amnesia, unconsciousness or immobilization (with increasing doses), the cardinal features of general anesthesia...
  49. Markus Amann; Fiscal Year: 2016
    ..b>Cardinal determinants of these characteristics include excessive exercise pressor reflex, premature fatigue, and ..
  50. MOLECULAR MECHANISMS OF THE MYOTONIC DYSTROPHY MUTATION
    MANI SUBRAMANIAM MAHADEVAN; Fiscal Year: 2013
    ..Surprisingly, we found that mice overexpressing a normal DMPK 3'UTR mRNA reproduced cardinal features of DM including myotonia, cardiac conduction abnormalities, DM histopathology and RNA splicing defects ..
  51. Paul J Chiao; Fiscal Year: 2014
    ..profile for pancreatic caner is emerging, the role of specific genetic alterations that initiate and mediate its cardinal clinical features of locally aggressive growth, metastasis, and chemotherapy resistance, remains unresolved...
  52. Fadi G Lakkis; Fiscal Year: 2016
    A cardinal feature of the adaptive immune response is its ability to generate long-lived populations of memory T lymphocytes. Memory T cells that recognize donor allo-antigens jeopardize the survival of life- saving organ transplants...
  53. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Persistent damage to airway epithelium is a cardinal feature in chronic, severe asthma, and repair of this damaged epithelium frequently does not occur in asthmatic airways...
  54. Zhang Xu Liu; Fiscal Year: 2016
    ..Hepatic inflammation is the cardinal feature of AH, and this progressive necro-inflammatory reaction in the liver results in a high, short-term ..
  55. Vishwa Deep Dixit; Fiscal Year: 2014
    ..In addition, key proteins like CARDINAL/CARD8, which are required for the Nlrp3 inflammasome assembly in humans, are absent in mice...
  56. Recognition of microbes by NKT cells at the lung mucosal surface
    Dale T Umetsu; Fiscal Year: 2010
    ..directly activate pulmonary NKT cells in mice and induce airway inflammation and airway hyperreactivity (AHR), a cardinal feature of asthma...
  57. Alan Kim Johnson; Fiscal Year: 2014
    ..application proposes to test this hypothesis by studying the co-morbidity of heart failure and anhedonia, a cardinal sign of depressed mood, and by investigating the role of mineralocorticoids generated during heart failure in ..
  58. MSC Therapy & Immune Response in Children with Osteogenesis Imperfecta
    Edwin M Horwitz; Fiscal Year: 2010
    ..with severe osteogenesis imperfecta (OI), a genetic disorder of bone in which marked growth deficiency is a cardinal manifestation...
  59. DICHLOROACETATE KINETICS, METABOLISM AND TOXICOLOGY
    PETER STACPOOLE; Fiscal Year: 2009
    ..It is also employed as an investigational drug for treatment of congenital forms of lactic acidosis (CLA). The cardinal manifestations of chronic DCA exposure are reversible hepatotoxicity and peripheral neuropathy (PN) in humans and ..
  60. Ethnic difference in prostate cancer
    Timothy R Rebbeck; Fiscal Year: 2010
    ..and comparable protocols for the identification of incident prostate cancer cases and controls in Philadelphia and Dakar. At both locations, risk factor information is obtained from a questionnaire interview, a biosample containing DNA ..
  61. Imaging of Cardiac Transplant Rejection
    Matthias Nahrendorf; Fiscal Year: 2013
    ..An increasing body of work suggests that macrophages are highly abundant in rejected allografts, and exhibit cardinal cellular and molecular functions...
  62. NKT cells recognize and respond to microbes at mucosal surfaces
    Dale T Umetsu; Fiscal Year: 2010
    ..directly activate pulmonary NKT cells in mice and induce airway inflammation and airway hyperreactivity (AHR), a cardinal feature of asthma...
  63. The Role of the Cortex in Discoordination After Stroke
    Julius Dewald; Fiscal Year: 2009
    Loss of independent control of joint movement in the impaired limb is a cardinal sign of stroke that is expressed in the form of stereotypic multi-joint movement patterns...
  64. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    ..While DBS therapy is generally safe and effective for reducing cardinal symptoms of the approved diseases, it often has significant behavioral and cognitive side effects and limits on ..
  65. Targeting Akt/NF-kappa beta for Pancreatic Cancer Therapy
    Fazlul Sarkar; Fiscal Year: 2007
    ..in pancreatic cancer induces downstream target genes, such as uPA, VEGF, IL-8 and Bcl-xl that may mediate its cardinal clinical features of locally aggressive growth, metastasis, and chemotherapy resistance...
  66. Mechanisms of Early Kidney Development
    TERI MAUCH; Fiscal Year: 2007
    ..The pronephros lies sandwiched between the post-cardinal vein and the aorta in the early embryo, and the PM contains angioblasts...
  67. Gastrointestinal safety and therapeutics of oil-based Phosphatidylcholine-NSAIDS
    Lenard M Lichtenberger; Fiscal Year: 2010
    ..and manufacturer (Cardinal Health), the FDA has issued an IND for the ibuprofen-PC and has approved an accelerated 505(b)(2) regulatory path ..
  68. Using rt-fMRI to Modulate Neural Responses to Drug and Nondrug Rewards in Cocaine
    MATTHEW contact SHANE; Fiscal Year: 2010
    ..This suggests that a cardinal characteristic of dependency may be reduced ability to manage goal-directed behavior in situations when drug- ..
  69. Roles of Mast Cells in Inflammatory Pain
    Devavani Chatterjea; Fiscal Year: 2010
    ..Pain is one of the cardinal signs of the inflammatory response and is potentiated by sensitization of the nociceptive neurons...