TUBB8

Summary

Gene Symbol: TUBB8
Description: tubulin beta 8 class VIII
Alias: OOMD, OOMD2, bA631M21.2, tubulin beta-8 chain, HSA10p15 beta-tubulin 4Q
Species: human

Top Publications

  1. pmc HIV-1 rev depolymerizes microtubules to form stable bilayered rings
    N R Watts
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    J Cell Biol 150:349-60. 2000
  2. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
  3. ncbi Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression
    Mayte Coiras
    AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Proteomics 6:S63-73. 2006
  4. pmc Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity
    Minghao He
    Center for AIDS Research, College of Life Sciences, Nankai University, Tianjin, China
    PLoS ONE 8:e67186. 2013
  5. pmc Mutations in TUBB8 and Human Oocyte Meiotic Arrest
    Ruizhi Feng
    From the State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, MOE Key Laboratory of Contemporary Anthropology, and Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University R F, Q S, Y X, R Q, X W, H W, Q L, Q X, L J, L H, L W, Shanghai JI Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University X S, M Y, J C, Department of Otolaryngology, Eye and ENT Hospital, Fudan University L G, Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, and Shanghai Medical College, Fudan University Y F, The Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University Y K, Z Y, S Z, PA 19486
    N Engl J Med 374:223-32. 2016
  6. pmc Mutations in TUBB8 cause a multiplicity of phenotypes in human oocytes and early embryos
    Ruizhi Feng
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, The People s Republic of China Institutes of Biomedical Sciences, Fudan University, Shanghai, The People s Republic of China
    J Med Genet 53:662-71. 2016
  7. ncbi Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development
    Biaobang Chen
    State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, MOE Key Laboratory of Contemporary Anthropology and School of Life Sciences, Fudan University, Shanghai 200032
    Hum Reprod . 2016
  8. ncbi Identification of a novel beta-tubulin subfamily with one member (TUBB4Q) located near the telomere of chromosome region 4q35
    M van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cytogenet Cell Genet 88:316-21. 2000
  9. pmc A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes
    Michel van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Am J Hum Genet 70:269-78. 2002

Detail Information

Publications9

  1. pmc HIV-1 rev depolymerizes microtubules to form stable bilayered rings
    N R Watts
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    J Cell Biol 150:349-60. 2000
    ..These results suggest that Rev may interact with MTs to induce their destabilization, a proposition consistent with the previously described disruption of MTs after HIV-1 infection...
  2. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
    ..Our findings reveal a strategy by which Tat induces apoptosis by targeting the microtubule network. Thus HIV-1 Tat joins a growing list of pathogen-derived proteins that target the cytoskeleton of host cells...
  3. ncbi Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression
    Mayte Coiras
    AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Proteomics 6:S63-73. 2006
    ..In conclusion, in addition to its role in viral mRNA elongation, the proteomic approach has provided insight into the way that Tat modifies host cell gene expression...
  4. pmc Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity
    Minghao He
    Center for AIDS Research, College of Life Sciences, Nankai University, Tianjin, China
    PLoS ONE 8:e67186. 2013
    ..Our findings suggest that Tat may regulate diverse cellular activities through binding to different proteins and that the acetylation of distinct lysine residues in Tat may modulate its interaction with various partners. ..
  5. pmc Mutations in TUBB8 and Human Oocyte Meiotic Arrest
    Ruizhi Feng
    From the State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, MOE Key Laboratory of Contemporary Anthropology, and Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University R F, Q S, Y X, R Q, X W, H W, Q L, Q X, L J, L H, L W, Shanghai JI Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University X S, M Y, J C, Department of Otolaryngology, Eye and ENT Hospital, Fudan University L G, Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, and Shanghai Medical College, Fudan University Y F, The Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University Y K, Z Y, S Z, PA 19486
    N Engl J Med 374:223-32. 2016
    ..We performed Sanger sequencing of a candidate gene, TUBB8, in DNA samples from these members, additional family members, and members of 23 other affected families...
  6. pmc Mutations in TUBB8 cause a multiplicity of phenotypes in human oocytes and early embryos
    Ruizhi Feng
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, The People s Republic of China Institutes of Biomedical Sciences, Fudan University, Shanghai, The People s Republic of China
    J Med Genet 53:662-71. 2016
    b>TUBB8 is a primate-specific β-tubulin isotype whose expression is confined to oocytes and the early embryo. We previously found that mutations in TUBB8 caused oocyte maturation arrest...
  7. ncbi Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development
    Biaobang Chen
    State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, MOE Key Laboratory of Contemporary Anthropology and School of Life Sciences, Fudan University, Shanghai 200032
    Hum Reprod . 2016
    Are there any new type of mutations and novel phenotypes in patients with arrest in oocyte maturation, fertilization or early embryonic development having tubulin beta eight class VIII (TUBB8) mutations?
  8. ncbi Identification of a novel beta-tubulin subfamily with one member (TUBB4Q) located near the telomere of chromosome region 4q35
    M van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cytogenet Cell Genet 88:316-21. 2000
    ..Although the chromosome 4q35 tubulin-member probably represents a pseudogene, ectopic expression due to a postulated position effect variegation (PEV), makes TUBB4Q an ideal dominant-negative candidate gene for FSHD1...
  9. pmc A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes
    Michel van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Am J Hum Genet 70:269-78. 2002
    ..Our analysis emphasizes the dynamic nature of duplication-mediated genome evolution and the delicate balance between gene acquisition and silencing...