Genomes and Genes
Gene Symbol: TUBB4A
Description: tubulin beta 4A class IVa
Alias: DYT4, TUBB4, beta-5, tubulin beta-4A chain, dystonia 4, torsion (autosomal dominant), tubulin beta-4 chain, tubulin, beta 4, tubulin, beta, 5
Publications194 found, 100 shown here
- Evidence for locus heterogeneity in autosomal dominant torsion dystoniaF Ahmad
University Department of Clinical Neurology, Institute of Neurology, London, United Kingdom
Genomics 15:9-12. 1993..This study provides evidence for locus heterogeneity in autosomal dominant ITD and also gives additional information on gene order in chromosome 9q...
- HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative BimDan Chen
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
EMBO J 21:6801-10. 2002..Our findings reveal a strategy by which Tat induces apoptosis by targeting the microtubule network. Thus HIV-1 Tat joins a growing list of pathogen-derived proteins that target the cytoskeleton of host cells...
- HIV-1 Tat protein enhances microtubule polymerizationJean de Mareuil
UMR Univ, Med, CNRS FRE 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
Retrovirology 2:5. 2005..We compared the effect on tubulin polymerization of these Tat variants and peptides corresponding to different parts of the Tat sequence, with paclitaxel, an anti-cancer drug that targets microtubules...
- HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?Mauro Giacca
Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Retrovirology 2:7. 2005..Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis...
- Whispering dysphonia in an Australian family (DYT4): a clinical and genetic reappraisalRobert A Wilcox
Neurology Department, Flinders Medical Centre, Adelaide, SA, Australia
Mov Disord 26:2404-8. 2011The designation, DYT4, was assigned to an Australian family with whispering dysphonia...
- The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosisGrant R Campbell
CNRS Formation de Recherche en Evolution 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385 Marseille, France
J Biol Chem 279:48197-204. 2004..The glutamine-rich region of Tat appears to be involved in the Tat-mediated apoptosis of T-cells...
- Integrins in cell adhesion and signalingS K Akiyama
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Hum Cell 9:181-6. 1996..The beta 1, beta 3, and beta 5 integrin intracellular domains are sufficient to initiate signal transduction pathways...
- Effect of interleukin-4 and interleukin-10 on leucocyte migration and nitric oxide production in the mouseM Perretti
Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London
Br J Pharmacol 116:2251-7. 1995..Keywords: Inflammation; neutrophils; CDllb; interleukin-l; interleukin-8; nitric oxide synthase..
- Cholesterol chlorohydrin synthesis by the myeloperoxidase-hydrogen peroxide-chloride system: potential markers for lipoproteins oxidatively damaged by phagocytesJ W Heinecke
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
Biochemistry 33:10127-36. 1994..Because chlorohydrins are stable under our experimental conditions, chlorinated sterols may prove useful as markers for lipoproteins oxidatively damaged by activated phagocytes...
- Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genesL R Gottschalk
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650
Mol Cell Biol 10:5486-95. 1990..Jurkat T-cell nuclear extracts allowed the identification of five nuclear protein-binding sites, T beta 1 to T beta 5, within the enhancer element...
- T cell receptor V beta repertoire in mice lacking endogenous mouse mammary tumor provirusM Y Braun
Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland
Eur J Immunol 25:857-62. 1995..usage in these mice was analyzed using monoclonal antibodies specific for TcR V beta 2, V beta 3, V beta 4, V beta 5, V beta 6, V beta 7, V beta 8, V beta 11, V beta 12 and V beta 14 segments...
- Treatment of isografted 9L rat brain tumors with beta-5-o-carboranyl-2'-deoxyuridine neutron capture therapyR F Schinazi
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Clin Cancer Res 6:725-30. 2000..036), which may correlate with the decreased tumor selectivity for D-CDU observed at the higher dose. Additional pharmacodynamic studies are warranted to determine optimal dosing strategies for D-CDU...
- Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometryJ Plat
Maastricht University, Department of Human Biology, P O Box 616, 6200 MD, Maastricht, The Netherlands
J Lipid Res 42:2030-8. 2001..The relevance of these findings therefore deserves further exploration...
- Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectinM Delannet
, Institut Jacques Monod, , France
Development 120:2687-702. 1994..analyses revealed that neural crest cells expressed primarily the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins as possible vitronectin receptors...
- Bacterial metabolism of natural and synthetic sex hormones undergoing enterohepatic circulationJ Winter
St Luke s Roosevelt Institute for Health Sciences, New York, NY 10025
J Steroid Biochem 27:1145-9. 1987..The enzymes can also be used for titration of specific bacterial strains in fecal flora and as markers for bacterial identification in particular for the strains difficult to be defined by regular biochemical reactions...
- R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brainLylia Nini
Metabolic Diseases Branch, 10 8C 101, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
BMC Biochem 8:18. 2007..G beta 5 is the most structurally divergent G beta isoform and forms tight heterodimers with regulator of G protein ..
- Elevated levels of interleukin-8 and transforming growth factor-beta in bronchoalveolar lavage fluid from patients with bronchiolitis obliterans syndrome: proinflammatory role of bronchial epithelial cells. Munich Lung Transplant GroupA Elssner
Department of Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
Transplantation 70:362-7. 2000..Obliterative bronchiolitis (OB), the most important long-term complication after lung transplantation, is thought to be a manifestation of chronic rejection within the airways, with the hallmarks inflammation and fibroproliferation...
- Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O virusesHernando Duque
Foot and Mouth Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY 11944 0848, USA
J Virol 77:2500-11. 2003..Thus, the ability of the virus to utilize multiple integrins in vitro may be a reflection of the use of multiple receptors during the course of infection within the susceptible host...
- Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinitiesAdam P Silverman
Department of Bioengineering, Cancer Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
J Mol Biol 385:1064-75. 2009..Collectively, these data validate AgRP as a scaffold for protein engineering and demonstrate that modification of a single loop can lead to AgRP-based peptides with antibody-like affinities for their target...
- Characterization of the Mlsf system. II. Identification of mouse mammary tumor virus proviruses involved in the clonal deletion of self-Mlsf-reactive T cellsM Foo-Phillips
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
J Immunol 149:3440-7. 1992..We previously have reported that the ligand(s) for V beta 5, V beta 11, and V beta 12 behaves as a novel minor lymphocyte-stimulating (Mls) determinant(s), Mlsf, to induce ..
- The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1W M Jiang
Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand
Int Immunol 4:1031-40. 1992..consensus sequences corresponding to the beta 3 RGD-binding domain, yielded partial gene sequences for the beta 3, beta 5, and beta 6 subunits only...
- Avian integrin alpha v subunit associates with multiple beta subunits and shows tissue-specific variation in its associationR Rajaraman
Department of Medicine and Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
Exp Cell Res 205:25-31. 1993..Furthermore, immunoprecipitation studies revealed the presence of an unidentified 120-kDa subunit and an 85-kDa beta 5 subunit associated with the alpha v subunit in these cells...
- A frameshift mutation in the mouse alpha 1 glycine receptor gene (Glra1) results in progressive neurological symptoms and juvenile deathM S Buckwalter
Department of Human Genetics, University of Michigan Medical School, Medical Science II, Ann Arbor 48109 0618
Hum Mol Genet 3:2025-30. 1994..Glra1 assembles into a pentameric complex with the beta subunit of the glycine receptor (3 alpha (1)2 beta 5) to form a glycine-gated chloride channel...
- Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidneyH Rabb
Department of Internal Medicine, James A Haley Veterans Hospital, Tampa, FL 33612, USA
Am J Nephrol 16:402-8. 1996..alpha v-Subunit also associates with beta 5 to form an alpha v beta 5-complex, another vitronectin receptor...
- Early vitronectin receptor downregulation in a melanoma cell line during all-trans retinoic acid-induced apoptosisA Baroni
Departments of Dermatology and Experimental Medicine, II University of Naples, Naples, Italy
Br J Dermatol 148:424-33. 2003..In vivo and in vitro studies document that all trans-retinoid acids (ATRAs) inhibit growth-inducing apoptosis in melanomas...
- Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native statesColin J Bent
Department of Chemistry, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
J Bacteriol 186:2872-9. 2004..85 A and a third structure at pH 5.9 revealed the presence of a phosphate ion outside the active site. The fourth structure revealed the presence of an acetate molecule in the active site...
- Steroidogenesis in interstitial cells and microsomal fraction of immature pig testesG M Cooke
Department d anatomie et physiologie animale, , , St Hyacinthe, , Canada
J Reprod Fertil 91:175-85. 1991..The relative magnitudes of these populations indicate that most of the steroidogenic enzymes in the interstitial cells are not involved in the normal response to trophic stimulation...
- Experimental correlation between the pKa value of sulfonphthaleins with the nature of the substituents groupsPatricia Balderas-Hernández
Universidad Autonoma Metropolitana Iztapalapa, Departamento de Quimica, Apdo Postal 55 534, C P 09340 México D F, Mexico
Spectrochim Acta A Mol Biomol Spectrosc 69:1235-45. 2008..044. During the second stage, a study was conducted on the effect of the substituents present in the indicators to determine the effect of different functional groups on the pK(a) value corresponding to the last indicator's dissociation...
- Temporal and spatial regulation of integrin vitronectin receptor mRNAs in the embryonic chick retinaD B Gervin
Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
Invest Ophthalmol Vis Sci 37:1084-96. 1996..To identify integrin vitronectin receptor subunit mRNAs in the developing avian retina and to track their expression...
- An investigation of endogenous neuroactive steroid-induced modulation of ethanol's discriminative stimulus effectsC A Bowen
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
Behav Pharmacol 10:297-311. 1999..None of the six neuroactive steroid manipulations attenuated the effects of ethanol. These results demonstrate that a neuroactive steroid, endogenous in humans, can enhance the interoceptive effects of ethanol...
- A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicityGuido Bocci
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
Clin Pharmacol Ther 80:384-95. 2006....
- Expression of advanced glycation end products and related molecules in diabetic fibrovascular epiretinal membranesAhmed M Abu El-Asrar
Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia
Clin Exp Ophthalmol 38:57-64; quiz 87. 2010....
- Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosisM W Lark
Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA
J Pharmacol Exp Ther 291:612-7. 1999..Such a molecule may provide a novel therapeutic agent for the treatment of postmenopausal osteoporosis...
- A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alphaF Larrea
Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico 14000
Endocrinology 142:3791-9. 2001..These compounds, with ER alpha vs. ER beta selective agonist activity, may be useful in evaluating the distinct role of these receptors as well as in providing useful insights into ER action...
- Cerebrovascular effects of prostanoids: in-vitro studies in feline middle cerebral and basilar arteryE T Whalley
Dept of Physiological Sciences, University of Manchester
Prostaglandins 38:625-34. 1989..Under sustained tension conditions, endothelial factors do not appear to be involved in the responses to dilating prostanoids...
- A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6M Lehmann
Institut de Chimie Biologique, ER CNRS 079, , France
Cancer Res 54:2102-7. 1994..mAb 69-6-5 reacted with integrin alpha v beta 3 immunopurified from melanoma cells and integrins alpha v beta 5 and alpha v beta 6 immunopurified from pancreatic carcinoma cells...
- Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreadingM Bergman
Department of Pathology, University of Helsinki, Finland
Mol Cell Biol 15:711-22. 1995..Csk induction, the cells became spherical and more loosely attached to the culture substratum, and the alpha v beta 5 integrin complex (vitronectin receptor) of focal adhesions was redistributed to a novel type of structure ..
- Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoidsK Hirokawa
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London
Br J Pharmacol 113:1448-54. 1994..01).6. These data show that all-trans-RA and other active retinoids are able to block cytokine-stimulated expression of inducible NOS in cultured VSM cells and isolated aortic rings...
- Analysis of fibronectin and vitronectin receptors on human fetal skeletal muscle cells upon differentiationD Gullberg
Department of Animal Physiology, Uppsala University, Sweden
Exp Cell Res 220:112-23. 1995..Alpha v beta 1, and alpha v beta 3, are present at focal contacts throughout in vitro myogenesis whereas alpha v beta 5 appears to depend on an endogenously produced factor to localize to focal contacts...
- Modulation by transforming growth factor-beta 1 and interleukin-1 beta of proteoglycan release and chondrodisaccharide composition in porcine articular cartilageM Zanni
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
Semin Thromb Hemost 20:159-67. 1994....
- Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval developmentValérie S Langlois
Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
Gen Comp Endocrinol 166:417-27. 2010..We conclude that cyp19 and srd5 beta are active in early embryogenesis and larval development in Silurana tropicalis and their inhibition affected transcription of genes associated with the thyroid and reproductive axes...
- Changes in 5 alpha- and 5 beta-reductase pathways of aldosterone metabolism by dietary sodiumJ Gorsline
Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI 02906
Am J Hypertens 1:272-5. 1988..stimulated the 5 alpha-reductase pathway causing increases in the synthesis of 5 alpha-dihydroaldosterone and 3 beta 5 alpha-tetrahydroaldosterone, as well as certain polar, hydroxylated metabolites of aldosterone...
- GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitroP Lumley
Department of Cardiovascular Pharmacology, Glaxo Group Research Ltd, Herts
Br J Pharmacol 97:783-94. 1989..This profile of action, coupled to its long duration of effect in man described elsewhere, make it an ideal drug tool for elucidating the physiological and pathophysiological role of thromboxane A2...
- Expression of active rat DNA polymerase beta in Escherichia coliT Date
Department of Biochemistry, Kanazawa Medical University, Ishikawa, Japan
Biochemistry 27:2983-90. 1988..The recombinant clone, JMp beta 5, obtained by transfection of E...
- A single point mutation increases the affinity of serotonin 5-HT1D alpha, 5-HT1D beta, 5-HT1E and 5-HT1F receptors for beta-adrenergic antagonistsN Adham
Synaptic Pharmaceutical Corporation, Paramus, N J 07652
Neuropharmacology 33:387-91. 1994..57 nM (mutant 5-HT1E), whereas the wild-type receptors failed to show any specific binding with this radioligand in the same concentration range used for the mutant receptors.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Human mast cells derived from fetal liver cells cultured with stem cell factor express a functional CD51/CD61 (alpha v beta 3) integrinY Shimizu
Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
Blood 86:930-9. 1995..Expression of cell surface CD29 (beta 1), CD18 (beta 2), CD61 (beta 3), and beta 5 integrins was investigated on such cells by flow cytometry and adhesion measurements...
- CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domainT M Grzeszkiewicz
Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
J Biol Chem 276:21943-50. 2001..Together, these findings establish CYR61 as a novel ligand for integrin alpha(v)beta(5) and show that CYR61 interacts with distinct integrins to mediate disparate activities in a cell type-specific manner...
- Modular synthesis of 5-substituted thiophen-2-yl C-2'-deoxyribonucleosidesJan Bárta
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences and IOCB Research Center, Prague 6, Czech Republic
J Org Chem 73:3798-806. 2008..Title 5-arylthiophene C-nucleosides 6 exhibit interesting fluorescent properties with emission maxima varying from 339 to 396 nm depending on the aryl group attached...
- Differential expression and comparative subcellular localization of estrogen receptor beta isoforms in virally transformed and normal cultured human lens epithelial cellsPatrick R Cammarata
Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Exp Eye Res 81:165-75. 2005..The differential subcellular partitioning of ERbeta-1 to the mitochondria and ERbeta-2 to the nucleus suggests a new aspect of regulation and function of the estrogen signalling system...
- KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrinJuan J Calvete
Instituto de Biomedicina de Valencia, C S I C, Jaime Roig 11, 46010 Valencia, Spain
Curr Pharm Des 13:2853-9. 2007..Here we discuss structure-function correlations of the novel group of specific (K/R)TS-disintegrins targeting the alpha(1)beta(1) integrin...
- Reaction of cholesterol 5,6-epoxides with simulated gastric juiceG Maerker
U S Department of Agriculture, Eastern Regional Research Center, Philadelphia, PA 19118
Lipids 23:761-5. 1988..The data further suggest that residual chlorohydrins surviving stomach residence can be expected to revert to epoxide in the more alkaline intestinal environment...
- Differential role of alpha(v)beta(3) and alpha(v)beta(5) integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenovirusesDragomira Majhen
Laboratory for Genotoxic Agents, Division of Molecular Biology, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia
Virus Res 139:64-73. 2009..We conclude that alpha(v)beta(3) integrin is an efficient adenovirus internalization receptor, but cannot functionally replace alpha(v)beta(5) in endosomal release...
- Alpha v-integrins in human melanoma: gain of alpha v beta 3 and loss of alpha v beta 5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude miceE H Danen
Department of Pathology, University Hospital Nijmegen, The Netherlands
Int J Cancer 61:491-6. 1995..We observed that alpha v beta 5 was the alpha v-integrin expressed in all common nevocellular nevi, in 78% of dysplastic nevi, in 63% of early ..
- Effects of the isoprostane, 8-epi-prostaglandin F2 alpha, on the contractility of the human myometrium in vitroD Crankshaw
Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
Eur J Pharmacol 285:151-8. 1995..It is concluded that in the non-pregnant human myometrium 8-epi-prostaglandin F2 alpha is a medium potency contractile agonist acting predominantly at the TP receptor...
- The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migrationSriparna Bagchi
Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
J Biol Chem 280:39050-7. 2005..Thus, the RGD-dependent interaction between the P2Y(2)R and alpha(v) integrins is necessary for the P2Y(2)R to activate G(o) and to initiate G(o)-mediated signaling events leading to chemotaxis...
- Structural characterization of the lignin from jute (Corchorus capsularis) fibersJosé C Del Río
Instituto de Recursos Naturales y Agrobiologia de Sevilla, CSIC, PO Box 1052, E 41080 Seville, Spain
J Agric Food Chem 57:10271-81. 2009....
- Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth musclesM L Ogletree
Pharmacology Department, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey
J Pharmacol Exp Ther 260:789-94. 1992..1 to 30 nm.(abstract truncated at 250 words)..
- An endogenous retrovirus mediating deletion of alpha beta T cells?D L Woodland
Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38106
Nature 349:529-30. 1991..The deletion of I-E-reactive V beta 5.2-bearing T cells is dependent on the coexpression of an I-E tolerogenic coligand (Etc)14 and the gene for one of ..
- Molecular cloning and expression of mouse mg(2+)-dependent protein phosphatase beta-4 (type 2C beta-4)S Kato
Department of Biochemistry, Tohoku University, Sendai, Japan
Arch Biochem Biophys 318:387-93. 1995..These results suggest that the complex structure of MPP beta isoforms and their tissue- and developmental stage-specific expression reflect the variety of their physiological functions...
- Molecular organization of the gene encoding Xenopus laevis transforming growth factor-beta 5U D Vempati
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
Biochem Mol Biol Int 45:997-1003. 1998..TGF-beta 5 cDNA was cloned from Xenopus laevis and this isoform is unique to the amphibians...
- Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infectionsM Noutsias
Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
Circulation 104:275-80. 2001..Knowledge of CAR localization in the human cardiovascular system is limited but important with respect to CAR-dependent viral infections and gene transfer using CAR-dependent viral vectors...
- Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in miceNiels Reinmuth
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Cancer Res 63:2079-87. 2003..The use of agents such as integrin antagonists that target multiple cell types involved in angiogenesis may be a more effective method of inhibiting angiogenesis than agents targeting only the endothelial cells...
- Rat DNA polymerase beta substitutes the repairing activity of DNA polymerase I in the lethal effect of UV lightR Hernández-Escamilla
Lab de Tecnología del DNA, ENCB, IPN México 11340 DF México
Rev Latinoam Microbiol 44:58-64. 2002..The oriC origin of replication from p beta 5 was replaced by the rep origin from pSC101 and named p beta 6...
- Dopamine D1/D5 receptor activation reverses NMDA receptor-dependent long-term depression in rat hippocampusBruce G Mockett
Department of Psychology, University of Otago, Dunedin, New Zealand
J Neurosci 27:2918-26. 2007..Reversal of the LTD by SKF 38393 was associated with rephosphorylation of this same residue. Together, these findings demonstrate a new role for dopamine in the neuromodulation of hippocampal LTD...
- Effects of a biologically relevant antioxidant on the dehydrogenative polymerization of coniferyl alcoholAnders Holmgren
Division of Wood Chemistry and Pulp Technology, Department of Fibre and Polymer Technology, Royal Institute of Technology, KTH, 10044 Stockholm, Sweden
Biomacromolecules 9:3378-82. 2008..The chemistry of this antioxidant effect during dehydrogenative polymerization and the potential biological significance (cell wall lignification) of these observations are discussed...
- Beta-5 score to evaluate pig islet graft function in a primate pre-clinical modelYasuhiro Igarashi
Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
Xenotransplantation 17:449-59. 2010..We developed a composite scoring system to accurately assess pig islet function in pre-clinical primate studies...
- Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomesP J Dyson
Clinical Research Centre, Harrow, Middlesex, UK
Nature 349:531-2. 1991..3 T cells by Mls-2a and Mls-3a; V beta 11 T cells by ligands encoded by independently segregating genes; and V beta 5 T cells by ligands encoded by two genes...
- Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2M Bai
Biology Department, Brookhaven National Laboratory, Upton, New York 11973
J Virol 68:5925-32. 1994..cells did attach to surfaces coated with either protein and pretreatment of the cells with an integrin alpha v beta 5 monoclonal antibody reduced attachment to background levels...
- Role of thromboxane A2 in bradykinin-induced human isolated small bronchi contractionM Molimard
Laboratoire de Pharmacologie, , France
Eur J Pharmacol 278:49-54. 1995..The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation...
- Cloning and sequence analysis of the rat tumor necrosis factor-encoding genesJ Kwon
Department of Cell Biology, University of Alabama at Birmingham 35294
Gene 132:227-36. 1993..The two genes are tandemly arranged with TNF-beta 5' to TNF-alpha and separated by approximately 1...
- The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrinB Mikami
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461
Biochemistry 32:6836-45. 1993..a smaller globular region formed by long loops (L3, L4, and L5) extending from beta-strands beta 3, beta 4, and beta 5. Between the two regions is a cleft that opens into a pocket whose floor contains the postulated catalytic center ..
- Cloning and tissue distribution of the human G protein beta 5 cDNAP G Jones
Wyeth Ayerst Research, Princeton, NJ 08543, USA
Biochim Biophys Acta 1402:288-91. 1998Heterotrimeric G proteins integrate signals between receptors and effector proteins. We have cloned the human beta 5 subunit from a human brain cDNA library...
- Effect of nepadutant at tachykinin NK(2) receptors in human intestine and urinary bladderR Patacchini
Pharmacology Department, Research Laboratories, Menarini Ricerche SpA, via Rismondo 12 A, 50131, Florence, Italy
Eur J Pharmacol 398:389-97. 2000....
- Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomesE Witt
Institut fur Biochemie, Charité Humboldt University Medical School, Monbijoustr 2, Berlin, 10117, Germany
J Mol Biol 301:1-9. 2000..To analyse the role of the beta 5 propeptide for proper maturation and incorporation of the beta 5 subunit into the complex, human T2 cells, which ..
- New insights into p53 regulation and gene therapy for cancerA G Zeimet
Department of Obstetrics and Gynecology, University Hospital, Innsbruck, Austria
Biochem Pharmacol 60:1153-63. 2000....
- Synchronous deletion of Mtv-superantigen-reactive thymocytes in the CD3(medium/high) CD4(+)CD8(+) subsetM A Sheard
Department of Cellular and Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, The Czech Republic
Scand J Immunol 52:550-4. 2000..Deletion of V beta 3(+), V beta 5(+), V beta 11(+), and V beta 17(+) Mtv-SAG-reactive thymocytes was found to occur synchronously in the most mature ..
- Progesterone and the oligodendroglial lineage: stage-dependent biosynthesis and metabolismN Gago
INSERM U 488, Bicetre, France
Glia 36:295-308. 2001..PROG synthesis and metabolism and the dramatic changes in neurosteroidogenesis observed during the oligodendroglial differentiation may contribute to oligodendrocyte development or the myelination process...
- Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activationFlorian Blaschke
Deutsches Herzzentrum Berlin, Department of Medicine Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
Basic Res Cardiol 97:334-42. 2002....
- G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interactionD Scott Witherow
Department of Molecular and Cellular Pharmacology and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
J Biol Chem 278:21307-13. 2003..Gbeta5 complex and cyan fluorescence protein-tagged Galphaq, indicating a direct interaction between these molecules...
- Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesionVadim Pedchenko
Division of Nephrology, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Biol Chem 279:2772-80. 2004..Therefore, the RGD site, in addition to non-RGD motifs, may contribute to the mechanisms of endothelial cell adhesion in the human vasculature and the anti-angiogenic activity of the RGD-alpha3NC1 domain...
- alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitroRiccardo E Nisato
Department of Morphology, University Medical Center, Geneva, Switzerland
Angiogenesis 6:105-19. 2003..require cell-extracellular matrix interactions which are mediated in part via integrins alphav beta 3 and alphav beta 5, a formal demonstration that alphav beta 3 and alphav beta 5 are involved in endothelial-cell invasion and ..
- Integrins are not involved in the process of human sperm-oolemmal fusionKazuo Sengoku
Department of Obstetrics and Gynecology, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa, 0788510, Japan
Hum Reprod 19:639-44. 2004..We investigated whether integrins are required for the human sperm-oocyte binding and fusion processes...
- Solution structures of the inactive and BeF3-activated response regulator CheY2Hubert Riepl
Lehrstuhl fur Genetik, Universitat Regensburg, D 93040 Regensburg, Germany
J Mol Biol 338:287-97. 2004..We propose that these new features of response regulator activation, compared to other two-component systems, are the key for the observed unique phosphorylation, dephosphorylation and motor control mechanisms in S.meliloti...
- alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblastsAmelia K Scaffidi
Asthma and Allergy Research Institute and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia
J Biol Chem 279:37726-33. 2004..Our data provide a novel mechanism by which TGFbeta1 may contribute to abnormal wound healing and tissue fibrosis...
- Bisphosphonates: preclinical reviewJonathan R Green
Novartis Pharma AG, Klybeckstrasse 141, WKL 125 901, CH 4002 Basel, Switzerland
Oncologist 9:3-13. 2004..Further studies are needed to fully elucidate these biochemical mechanisms and to determine if the antitumor potential of bisphosphonates translates to the clinical setting...
- Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44Abdullah Karadag
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Res 65:11545-52. 2005....
- Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteinsVincent C Chen
Department of Chemistry, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
J Proteome Res 5:2123-34. 2006....
- Sexual function following radical prostatectomy: a prospective longitudinal study of cultural differences between Japanese and American menS Namiki
Department of Urology, David Geffen School of Medicine, Los Angeles 90095 1738, CA, USA
Prostate Cancer Prostatic Dis 11:298-302. 2008..57; 95% CI=0.44-0.75). This study demonstrates that Japanese and American men experience different patterns of recovery of their sexual function and bother after RP. Ethnicity may be a contributing factor...
- Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic ratsRosemary J Santulli
Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Rds, Spring House, PA 19477 0776, USA
J Pharmacol Exp Ther 324:894-901. 2008..Given this profile, JNJ-26076713 represents a potential therapeutic candidate for the treatment of age-related macular degeneration, macular edema, and proliferative diabetic retinopathy...
- Alpha v beta 3 and alpha v beta 5 integrins and their role in muscle precursor cell adhesionAndrea C M Sinanan
Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, UK
Biol Cell 100:465-77. 2008....
- Establishment and functional characterization of a tracheal epithelial cell line RTEC11 from transgenic rats harboring temperature-sensitive simian virus 40 large T-antigenYoshiaki Tabuchi
Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Toyama, Japan
Cell Biol Int 32:1344-52. 2008..the expression levels of Muc1 (mucin 1) and Scgb1a1 (uteroglobin), non-ciliated secretory cell markers, and Tubb4 (tubulin beta 4), a ciliated cell marker, were significantly increased under the cell growth-restricted condition...
- Cyclic tetraureas with variable flexibility--synthesis, crystal structures and propertiesDenys Meshcheryakov
Fachbereich Chemie, Pharmazie und Geowissenschaften, Abteilung Lehramt Chemie, Johannes Gutenberg Universitat Mainz, Duesbergweg 10 14, D 55099, Mainz, Germany
Org Biomol Chem 6:3244-55. 2008....
- Two-stage genome-wide association study identifies integrin beta 5 as having potential role in bull fertilityJean M Feugang
Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762, USA
BMC Genomics 10:176. 2009..We performed a comprehensive genome wide analysis of single nucleotide polymorphisms (SNP) for bull fertility followed by a second-stage replication in additional bulls for a restricted set of markers...
- An efficient chemical approach to bispecific antibodies and antibodies of high valencyJulia I Gavrilyuk
The Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
Bioorg Med Chem Lett 19:3716-20. 2009..Additionally, this approach should be applicable to chemically programmed vaccines...
- Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding proteinLeelamma M Panicker
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1752, USA
J Neurochem 113:1101-12. 2010..These results suggest that R7BP contributes significantly to the nuclear localization of endogenous G beta(5)/R7-RGS complex in brain...
- Combinatorial development of biomaterials for clonal growth of human pluripotent stem cellsYing Mei
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Mater 9:768-78. 2010..The structure-function methodology employed herein provides a general framework for the combinatorial development of synthetic substrates for stem cell culture...
- Novel betapapillomavirus associated with hand and foot papillomas in a cynomolgus macaqueC E Wood
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Vet Pathol 48:731-6. 2011..These findings characterize a new nonhuman beta-PV and provide additional support for the idea that tissue tropism among ancestral primate PVs developed prior to divergence of certain Old World primate lineages...
- Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivationY F Lin
Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan, ROC
Cell Death Dis 3:e434. 2012....
- A de novo mutation in the β-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellumCas Simons
Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia
Am J Hum Genet 92:767-73. 2013..probands, which revealed that all eleven H-ABC-diagnosed individuals carry the same de novo single-nucleotide TUBB4A mutation resulting in nonsynonymous change p.Asp249Asn...
- Pathogenic variants in TUBB4A are not found in primary dystoniaSatya R Vemula
From the Departments of Neurology and Anatomy and Neurobiology S R V, J X, M S L, University of Tennessee Health Science Center, Memphis, TN Bastian Voice Institute R W B, Downers Grove, IL Clinic for Child Neurology and Psychiatry D M, Medical Faculty University of Belgrade, Serbia and New York Center for Voice and Swallowing Disorders A B, NY
Neurology 82:1227-30. 2014To determine the contribution of TUBB4A, recently associated with DYT4 dystonia in a pedigree with "whispering dysphonia" from Norfolk, United Kingdom, to the etiopathogenesis of primary dystonia.
- G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalizationJ Christopher Octeau
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island, United States of America
PLoS ONE 9:e105791. 2014G beta 5 (Gbeta5, Gβ5) is a unique G protein β subunit that is thought to be expressed as an obligate heterodimer with R7 regulator of G protein signaling (RGS) proteins instead of with G gamma (Gγ) subunits...
- Interaction of RGS Protein with G beta subunit G beta 5.Vladlen Z Slepak; Fiscal Year: 2013..This research will contribute to understanding, at the molecular level, of cognitive, sensory, motor, metabolic and other functions of the nervous system. ..
- ROLE OF VITRONECTIN IN TUMOR CELL METASTASISRICHARD CHERNY; Fiscal Year: 1992..The isolated recombinant wild-type VN promotes cell adhesion similar to plasma- derived VN. This demonstrates a viable system to study the questions raised...
- Alpha v beta 5 integrin in retinal pigment epitheliumSILVIA FINNEMANN; Fiscal Year: 2004..The mechanisms of these interactions and the unique localization of v5 integrin in RPE are conserved among species. Exploring the 5 null mouse is thus important to understand human disease. ..
- Regulation of cell migration/metastasis by SrcJILL RICONO; Fiscal Year: 2005..Integrin alpha V beta 5 is known to cooperate with growth factor receptors and promote intracellular signaling events that influence cell ..
- ALPHA V INTEGRINS AND PULMONARY VASCULAR DEVELOPMENTSUSAN SCHACHTNER; Fiscal Year: 2001..research outlined in this proposal investigates the role of specific adhesion molecules (alpha v beta 3 , alpha v beta 5 integrins), in endothelial cell differentiation, migration and adhesion in the developing vessels in the lung...
- Molecular Imaging of Neoplasia Using NanoparticlesG Reddy; Fiscal Year: 2002..abstract_text> ..
- Contrasting Properties of Integrin Cytoplasmic DomainsRenata Pasqualini; Fiscal Year: 2004..v beta3 and alpha v beta5 focal adhesion preparations and panning of phage display peptide libraries on beta3 and beta 5 cytoplasmic domains...
- Structural Studies of Bacterial Competence ProteinsJohn Cavanagh; Fiscal Year: 2006..subtilis, but also in other important gram-positive (e.g. Streptococcus pneumoniae) and gram-negative (e.g. Neisseria gonorrhoeae and Haemophihts influenza) bacteria. ..
- TAP20, NOVEL INTEGRIN MODULATING PROTEINShaoqing Tang; Fiscal Year: 2001..We anticipate that these studies should provide data that will be useful in designing new strategic for pharmacologic intervention in ischemic vascular disease and cancer. ..
- Exercise-based Motivational Interviewing for FibromyalgiaDENNIS CHUA ANG; Fiscal Year: 2010..Furthermore, if proven efficacious, Ml could readily be applied to other chronically painful conditions (e.g. chronic back pain). ..
- Role of JAM Family in AngiogenesisUlhas P Naik; Fiscal Year: 2010..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
- Membrane Targeting of G ProteinsPhilip Wedegaertner; Fiscal Year: 2007..abstract_text> ..
- Postdoctoral Training Program in Cancer EpidemiologyLinda Van Horn; Fiscal Year: 2008..The ultimate success of the Program will be determined by the future contributions of the Fellows to the field in the academic/research setting. ..
- CELL ADHESION MOLECULES OF MAMMALIAN FERTILIZATIONJanice Evans; Fiscal Year: 2008..This research also will also address fundamental questions in cell adhesion biology by examining this interesting, biologically relevant cell-cell interaction event. ..
- Modulation of integrin function by cytoplasmic signalsUlhas Naik; Fiscal Year: 2007..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
- BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANTFrederica Perera; Fiscal Year: 2001..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
- Tracking Urogenital Sinus Cell ProgenyROBERT SIKES; Fiscal Year: 2004..abstract_text> ..
- VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.Frederica Perera; Fiscal Year: 2004....
- ENDOTHELIAL SIGNALING MECHANISMS IN LUNG INJURYSunita Bhattacharya; Fiscal Year: 2005..These mechanisms are highly relevant to the general understanding of the lung inflammatory response. No previous understanding of these mechanisms exists for lung endothelium in vivo. The proposed studies will be novel. ..
- Role of Osteopontin in Tumor PromotionPi Ling Chang; Fiscal Year: 2005..Together, these studies will provide a better understanding of the role of OPN in tumor promotion and may contribute to the design of a mechanism-based strategy for cancer prevention. ..
- CELL SURFACE STRUCTURE AND TRANSFORMATIONSRichard Hynes; Fiscal Year: 2005..Evaluation of the functions of cell adhesion proteins and the consequences of their misexpression in metastatic cells will lead to new leads for therapeutic interventions against metastasis. ..
- MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATIONPATRICK CAMMARATA; Fiscal Year: 2004..This study proposes to test the potential usefulness of enhancing myo-inositol efflux through chloride channels as a means for drug therapy to relieve intrafiber osmotic stress. ..
- P27Kipl deficiency, potential promoter of carcinogenesisKonstantin Christov Tzelkov; Fiscal Year: 2003..abstract_text> ..
- Osteopontin and microenvironment of initiated cellsPi Ling Chang; Fiscal Year: 2010..These proposed in vivo and in vitro studies will shed light on the molecular mechanism(s) by which a matricellular protein enhances the survival of transforming cells during early tumor promotion. ..
- ETHNIC DISPARITY IN THE USE OF JOINT ARTHROPLASTYDENNIS ANG; Fiscal Year: 2007..The Program Director, Munro Peacock, M.D., was appointed in July 1987. The GCRC was ..
- RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITYRonald Klein; Fiscal Year: 2002..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
- Primers for synthesizing full length cDNA clones and their usePatent Number: EP1396543-A2; Date:2004-03-10