TUBB4A

Summary

Gene Symbol: TUBB4A
Description: tubulin beta 4A class IVa
Alias: DYT4, TUBB4, beta-5, tubulin beta-4A chain, dystonia 4, torsion (autosomal dominant), tubulin beta-4 chain, tubulin, beta 4, tubulin, beta, 5
Species: human

Top Publications

  1. ncbi Evidence for locus heterogeneity in autosomal dominant torsion dystonia
    F Ahmad
    University Department of Clinical Neurology, Institute of Neurology, London, United Kingdom
    Genomics 15:9-12. 1993
  2. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
  3. pmc HIV-1 Tat protein enhances microtubule polymerization
    Jean de Mareuil
    UMR Univ, Med, CNRS FRE 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
    Retrovirology 2:5. 2005
  4. pmc HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
    Mauro Giacca
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Retrovirology 2:7. 2005
  5. doi Whispering dysphonia in an Australian family (DYT4): a clinical and genetic reappraisal
    Robert A Wilcox
    Neurology Department, Flinders Medical Centre, Adelaide, SA, Australia
    Mov Disord 26:2404-8. 2011
  6. ncbi The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis
    Grant R Campbell
    CNRS Formation de Recherche en Evolution 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385 Marseille, France
    J Biol Chem 279:48197-204. 2004
  7. ncbi Integrins in cell adhesion and signaling
    S K Akiyama
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Hum Cell 9:181-6. 1996
  8. pmc Effect of interleukin-4 and interleukin-10 on leucocyte migration and nitric oxide production in the mouse
    M Perretti
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London
    Br J Pharmacol 116:2251-7. 1995
  9. ncbi Cholesterol chlorohydrin synthesis by the myeloperoxidase-hydrogen peroxide-chloride system: potential markers for lipoproteins oxidatively damaged by phagocytes
    J W Heinecke
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Biochemistry 33:10127-36. 1994
  10. pmc Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes
    L R Gottschalk
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650
    Mol Cell Biol 10:5486-95. 1990

Research Grants

Patents

  1. Primers for synthesizing full length cDNA clones and their use

Detail Information

Publications194 found, 100 shown here

  1. ncbi Evidence for locus heterogeneity in autosomal dominant torsion dystonia
    F Ahmad
    University Department of Clinical Neurology, Institute of Neurology, London, United Kingdom
    Genomics 15:9-12. 1993
    ..This study provides evidence for locus heterogeneity in autosomal dominant ITD and also gives additional information on gene order in chromosome 9q...
  2. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
    ..Our findings reveal a strategy by which Tat induces apoptosis by targeting the microtubule network. Thus HIV-1 Tat joins a growing list of pathogen-derived proteins that target the cytoskeleton of host cells...
  3. pmc HIV-1 Tat protein enhances microtubule polymerization
    Jean de Mareuil
    UMR Univ, Med, CNRS FRE 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
    Retrovirology 2:5. 2005
    ..We compared the effect on tubulin polymerization of these Tat variants and peptides corresponding to different parts of the Tat sequence, with paclitaxel, an anti-cancer drug that targets microtubules...
  4. pmc HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
    Mauro Giacca
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Retrovirology 2:7. 2005
    ..Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis...
  5. doi Whispering dysphonia in an Australian family (DYT4): a clinical and genetic reappraisal
    Robert A Wilcox
    Neurology Department, Flinders Medical Centre, Adelaide, SA, Australia
    Mov Disord 26:2404-8. 2011
    The designation, DYT4, was assigned to an Australian family with whispering dysphonia...
  6. ncbi The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis
    Grant R Campbell
    CNRS Formation de Recherche en Evolution 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385 Marseille, France
    J Biol Chem 279:48197-204. 2004
    ..The glutamine-rich region of Tat appears to be involved in the Tat-mediated apoptosis of T-cells...
  7. ncbi Integrins in cell adhesion and signaling
    S K Akiyama
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Hum Cell 9:181-6. 1996
    ..The beta 1, beta 3, and beta 5 integrin intracellular domains are sufficient to initiate signal transduction pathways...
  8. pmc Effect of interleukin-4 and interleukin-10 on leucocyte migration and nitric oxide production in the mouse
    M Perretti
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London
    Br J Pharmacol 116:2251-7. 1995
    ..Keywords: Inflammation; neutrophils; CDllb; interleukin-l; interleukin-8; nitric oxide synthase..
  9. ncbi Cholesterol chlorohydrin synthesis by the myeloperoxidase-hydrogen peroxide-chloride system: potential markers for lipoproteins oxidatively damaged by phagocytes
    J W Heinecke
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Biochemistry 33:10127-36. 1994
    ..Because chlorohydrins are stable under our experimental conditions, chlorinated sterols may prove useful as markers for lipoproteins oxidatively damaged by activated phagocytes...
  10. pmc Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes
    L R Gottschalk
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650
    Mol Cell Biol 10:5486-95. 1990
    ..Jurkat T-cell nuclear extracts allowed the identification of five nuclear protein-binding sites, T beta 1 to T beta 5, within the enhancer element...
  11. ncbi T cell receptor V beta repertoire in mice lacking endogenous mouse mammary tumor provirus
    M Y Braun
    Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 25:857-62. 1995
    ..usage in these mice was analyzed using monoclonal antibodies specific for TcR V beta 2, V beta 3, V beta 4, V beta 5, V beta 6, V beta 7, V beta 8, V beta 11, V beta 12 and V beta 14 segments...
  12. ncbi Treatment of isografted 9L rat brain tumors with beta-5-o-carboranyl-2'-deoxyuridine neutron capture therapy
    R F Schinazi
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 6:725-30. 2000
    ..036), which may correlate with the decreased tumor selectivity for D-CDU observed at the higher dose. Additional pharmacodynamic studies are warranted to determine optimal dosing strategies for D-CDU...
  13. ncbi Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometry
    J Plat
    Maastricht University, Department of Human Biology, P O Box 616, 6200 MD, Maastricht, The Netherlands
    J Lipid Res 42:2030-8. 2001
    ..The relevance of these findings therefore deserves further exploration...
  14. pmc Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectin
    M Delannet
    , Institut Jacques Monod, , France
    Development 120:2687-702. 1994
    ..analyses revealed that neural crest cells expressed primarily the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins as possible vitronectin receptors...
  15. ncbi Bacterial metabolism of natural and synthetic sex hormones undergoing enterohepatic circulation
    J Winter
    St Luke s Roosevelt Institute for Health Sciences, New York, NY 10025
    J Steroid Biochem 27:1145-9. 1987
    ..The enzymes can also be used for titration of specific bacterial strains in fecal flora and as markers for bacterial identification in particular for the strains difficult to be defined by regular biochemical reactions...
  16. pmc R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain
    Lylia Nini
    Metabolic Diseases Branch, 10 8C 101, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biochem 8:18. 2007
    ..G beta 5 is the most structurally divergent G beta isoform and forms tight heterodimers with regulator of G protein ..
  17. ncbi Elevated levels of interleukin-8 and transforming growth factor-beta in bronchoalveolar lavage fluid from patients with bronchiolitis obliterans syndrome: proinflammatory role of bronchial epithelial cells. Munich Lung Transplant Group
    A Elssner
    Department of Internal Medicine I, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Transplantation 70:362-7. 2000
    ..Obliterative bronchiolitis (OB), the most important long-term complication after lung transplantation, is thought to be a manifestation of chronic rejection within the airways, with the hallmarks inflammation and fibroproliferation...
  18. pmc Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses
    Hernando Duque
    Foot and Mouth Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY 11944 0848, USA
    J Virol 77:2500-11. 2003
    ..Thus, the ability of the virus to utilize multiple integrins in vitro may be a reflection of the use of multiple receptors during the course of infection within the susceptible host...
  19. pmc Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities
    Adam P Silverman
    Department of Bioengineering, Cancer Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    J Mol Biol 385:1064-75. 2009
    ..Collectively, these data validate AgRP as a scaffold for protein engineering and demonstrate that modification of a single loop can lead to AgRP-based peptides with antibody-like affinities for their target...
  20. ncbi Characterization of the Mlsf system. II. Identification of mouse mammary tumor virus proviruses involved in the clonal deletion of self-Mlsf-reactive T cells
    M Foo-Phillips
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Immunol 149:3440-7. 1992
    ..We previously have reported that the ligand(s) for V beta 5, V beta 11, and V beta 12 behaves as a novel minor lymphocyte-stimulating (Mls) determinant(s), Mlsf, to induce ..
  21. ncbi The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1
    W M Jiang
    Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand
    Int Immunol 4:1031-40. 1992
    ..consensus sequences corresponding to the beta 3 RGD-binding domain, yielded partial gene sequences for the beta 3, beta 5, and beta 6 subunits only...
  22. ncbi Avian integrin alpha v subunit associates with multiple beta subunits and shows tissue-specific variation in its association
    R Rajaraman
    Department of Medicine and Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Cell Res 205:25-31. 1993
    ..Furthermore, immunoprecipitation studies revealed the presence of an unidentified 120-kDa subunit and an 85-kDa beta 5 subunit associated with the alpha v subunit in these cells...
  23. ncbi A frameshift mutation in the mouse alpha 1 glycine receptor gene (Glra1) results in progressive neurological symptoms and juvenile death
    M S Buckwalter
    Department of Human Genetics, University of Michigan Medical School, Medical Science II, Ann Arbor 48109 0618
    Hum Mol Genet 3:2025-30. 1994
    ..Glra1 assembles into a pentameric complex with the beta subunit of the glycine receptor (3 alpha (1)2 beta 5) to form a glycine-gated chloride channel...
  24. ncbi Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney
    H Rabb
    Department of Internal Medicine, James A Haley Veterans Hospital, Tampa, FL 33612, USA
    Am J Nephrol 16:402-8. 1996
    ..alpha v-Subunit also associates with beta 5 to form an alpha v beta 5-complex, another vitronectin receptor...
  25. ncbi Early vitronectin receptor downregulation in a melanoma cell line during all-trans retinoic acid-induced apoptosis
    A Baroni
    Departments of Dermatology and Experimental Medicine, II University of Naples, Naples, Italy
    Br J Dermatol 148:424-33. 2003
    ..In vivo and in vitro studies document that all trans-retinoid acids (ATRAs) inhibit growth-inducing apoptosis in melanomas...
  26. pmc Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states
    Colin J Bent
    Department of Chemistry, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Bacteriol 186:2872-9. 2004
    ..85 A and a third structure at pH 5.9 revealed the presence of a phosphate ion outside the active site. The fourth structure revealed the presence of an acetate molecule in the active site...
  27. ncbi Steroidogenesis in interstitial cells and microsomal fraction of immature pig testes
    G M Cooke
    Department d anatomie et physiologie animale, , , St Hyacinthe, , Canada
    J Reprod Fertil 91:175-85. 1991
    ..The relative magnitudes of these populations indicate that most of the steroidogenic enzymes in the interstitial cells are not involved in the normal response to trophic stimulation...
  28. ncbi Experimental correlation between the pKa value of sulfonphthaleins with the nature of the substituents groups
    Patricia Balderas-Hernández
    Universidad Autonoma Metropolitana Iztapalapa, Departamento de Quimica, Apdo Postal 55 534, C P 09340 México D F, Mexico
    Spectrochim Acta A Mol Biomol Spectrosc 69:1235-45. 2008
    ..044. During the second stage, a study was conducted on the effect of the substituents present in the indicators to determine the effect of different functional groups on the pK(a) value corresponding to the last indicator's dissociation...
  29. ncbi Temporal and spatial regulation of integrin vitronectin receptor mRNAs in the embryonic chick retina
    D B Gervin
    Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Invest Ophthalmol Vis Sci 37:1084-96. 1996
    ..To identify integrin vitronectin receptor subunit mRNAs in the developing avian retina and to track their expression...
  30. ncbi An investigation of endogenous neuroactive steroid-induced modulation of ethanol's discriminative stimulus effects
    C A Bowen
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Behav Pharmacol 10:297-311. 1999
    ..None of the six neuroactive steroid manipulations attenuated the effects of ethanol. These results demonstrate that a neuroactive steroid, endogenous in humans, can enhance the interoceptive effects of ethanol...
  31. ncbi A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity
    Guido Bocci
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Clin Pharmacol Ther 80:384-95. 2006
    ....
  32. doi Expression of advanced glycation end products and related molecules in diabetic fibrovascular epiretinal membranes
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia
    Clin Exp Ophthalmol 38:57-64; quiz 87. 2010
    ....
  33. ncbi Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis
    M W Lark
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA
    J Pharmacol Exp Ther 291:612-7. 1999
    ..Such a molecule may provide a novel therapeutic agent for the treatment of postmenopausal osteoporosis...
  34. ncbi A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha
    F Larrea
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico 14000
    Endocrinology 142:3791-9. 2001
    ..These compounds, with ER alpha vs. ER beta selective agonist activity, may be useful in evaluating the distinct role of these receptors as well as in providing useful insights into ER action...
  35. ncbi Cerebrovascular effects of prostanoids: in-vitro studies in feline middle cerebral and basilar artery
    E T Whalley
    Dept of Physiological Sciences, University of Manchester
    Prostaglandins 38:625-34. 1989
    ..Under sustained tension conditions, endothelial factors do not appear to be involved in the responses to dilating prostanoids...
  36. ncbi A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6
    M Lehmann
    Institut de Chimie Biologique, ER CNRS 079, , France
    Cancer Res 54:2102-7. 1994
    ..mAb 69-6-5 reacted with integrin alpha v beta 3 immunopurified from melanoma cells and integrins alpha v beta 5 and alpha v beta 6 immunopurified from pancreatic carcinoma cells...
  37. pmc Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading
    M Bergman
    Department of Pathology, University of Helsinki, Finland
    Mol Cell Biol 15:711-22. 1995
    ..Csk induction, the cells became spherical and more loosely attached to the culture substratum, and the alpha v beta 5 integrin complex (vitronectin receptor) of focal adhesions was redistributed to a novel type of structure ..
  38. pmc Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoids
    K Hirokawa
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, London
    Br J Pharmacol 113:1448-54. 1994
    ..01).6. These data show that all-trans-RA and other active retinoids are able to block cytokine-stimulated expression of inducible NOS in cultured VSM cells and isolated aortic rings...
  39. ncbi Analysis of fibronectin and vitronectin receptors on human fetal skeletal muscle cells upon differentiation
    D Gullberg
    Department of Animal Physiology, Uppsala University, Sweden
    Exp Cell Res 220:112-23. 1995
    ..Alpha v beta 1, and alpha v beta 3, are present at focal contacts throughout in vitro myogenesis whereas alpha v beta 5 appears to depend on an endogenously produced factor to localize to focal contacts...
  40. ncbi Modulation by transforming growth factor-beta 1 and interleukin-1 beta of proteoglycan release and chondrodisaccharide composition in porcine articular cartilage
    M Zanni
    Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Semin Thromb Hemost 20:159-67. 1994
    ....
  41. doi Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development
    Valérie S Langlois
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Gen Comp Endocrinol 166:417-27. 2010
    ..We conclude that cyp19 and srd5 beta are active in early embryogenesis and larval development in Silurana tropicalis and their inhibition affected transcription of genes associated with the thyroid and reproductive axes...
  42. ncbi Changes in 5 alpha- and 5 beta-reductase pathways of aldosterone metabolism by dietary sodium
    J Gorsline
    Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI 02906
    Am J Hypertens 1:272-5. 1988
    ..stimulated the 5 alpha-reductase pathway causing increases in the synthesis of 5 alpha-dihydroaldosterone and 3 beta 5 alpha-tetrahydroaldosterone, as well as certain polar, hydroxylated metabolites of aldosterone...
  43. pmc GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro
    P Lumley
    Department of Cardiovascular Pharmacology, Glaxo Group Research Ltd, Herts
    Br J Pharmacol 97:783-94. 1989
    ..This profile of action, coupled to its long duration of effect in man described elsewhere, make it an ideal drug tool for elucidating the physiological and pathophysiological role of thromboxane A2...
  44. ncbi Expression of active rat DNA polymerase beta in Escherichia coli
    T Date
    Department of Biochemistry, Kanazawa Medical University, Ishikawa, Japan
    Biochemistry 27:2983-90. 1988
    ..The recombinant clone, JMp beta 5, obtained by transfection of E...
  45. ncbi A single point mutation increases the affinity of serotonin 5-HT1D alpha, 5-HT1D beta, 5-HT1E and 5-HT1F receptors for beta-adrenergic antagonists
    N Adham
    Synaptic Pharmaceutical Corporation, Paramus, N J 07652
    Neuropharmacology 33:387-91. 1994
    ..57 nM (mutant 5-HT1E), whereas the wild-type receptors failed to show any specific binding with this radioligand in the same concentration range used for the mutant receptors.(ABSTRACT TRUNCATED AT 250 WORDS)..
  46. ncbi Human mast cells derived from fetal liver cells cultured with stem cell factor express a functional CD51/CD61 (alpha v beta 3) integrin
    Y Shimizu
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
    Blood 86:930-9. 1995
    ..Expression of cell surface CD29 (beta 1), CD18 (beta 2), CD61 (beta 3), and beta 5 integrins was investigated on such cells by flow cytometry and adhesion measurements...
  47. ncbi CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain
    T M Grzeszkiewicz
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
    J Biol Chem 276:21943-50. 2001
    ..Together, these findings establish CYR61 as a novel ligand for integrin alpha(v)beta(5) and show that CYR61 interacts with distinct integrins to mediate disparate activities in a cell type-specific manner...
  48. doi Modular synthesis of 5-substituted thiophen-2-yl C-2'-deoxyribonucleosides
    Jan Bárta
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences and IOCB Research Center, Prague 6, Czech Republic
    J Org Chem 73:3798-806. 2008
    ..Title 5-arylthiophene C-nucleosides 6 exhibit interesting fluorescent properties with emission maxima varying from 339 to 396 nm depending on the aryl group attached...
  49. ncbi Differential expression and comparative subcellular localization of estrogen receptor beta isoforms in virally transformed and normal cultured human lens epithelial cells
    Patrick R Cammarata
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Exp Eye Res 81:165-75. 2005
    ..The differential subcellular partitioning of ERbeta-1 to the mitochondria and ERbeta-2 to the nucleus suggests a new aspect of regulation and function of the estrogen signalling system...
  50. ncbi KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrin
    Juan J Calvete
    Instituto de Biomedicina de Valencia, C S I C, Jaime Roig 11, 46010 Valencia, Spain
    Curr Pharm Des 13:2853-9. 2007
    ..Here we discuss structure-function correlations of the novel group of specific (K/R)TS-disintegrins targeting the alpha(1)beta(1) integrin...
  51. ncbi Reaction of cholesterol 5,6-epoxides with simulated gastric juice
    G Maerker
    U S Department of Agriculture, Eastern Regional Research Center, Philadelphia, PA 19118
    Lipids 23:761-5. 1988
    ..The data further suggest that residual chlorohydrins surviving stomach residence can be expected to revert to epoxide in the more alkaline intestinal environment...
  52. doi Differential role of alpha(v)beta(3) and alpha(v)beta(5) integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruses
    Dragomira Majhen
    Laboratory for Genotoxic Agents, Division of Molecular Biology, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia
    Virus Res 139:64-73. 2009
    ..We conclude that alpha(v)beta(3) integrin is an efficient adenovirus internalization receptor, but cannot functionally replace alpha(v)beta(5) in endosomal release...
  53. ncbi Alpha v-integrins in human melanoma: gain of alpha v beta 3 and loss of alpha v beta 5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice
    E H Danen
    Department of Pathology, University Hospital Nijmegen, The Netherlands
    Int J Cancer 61:491-6. 1995
    ..We observed that alpha v beta 5 was the alpha v-integrin expressed in all common nevocellular nevi, in 78% of dysplastic nevi, in 63% of early ..
  54. ncbi Effects of the isoprostane, 8-epi-prostaglandin F2 alpha, on the contractility of the human myometrium in vitro
    D Crankshaw
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 285:151-8. 1995
    ..It is concluded that in the non-pregnant human myometrium 8-epi-prostaglandin F2 alpha is a medium potency contractile agonist acting predominantly at the TP receptor...
  55. ncbi The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration
    Sriparna Bagchi
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 280:39050-7. 2005
    ..Thus, the RGD-dependent interaction between the P2Y(2)R and alpha(v) integrins is necessary for the P2Y(2)R to activate G(o) and to initiate G(o)-mediated signaling events leading to chemotaxis...
  56. doi Structural characterization of the lignin from jute (Corchorus capsularis) fibers
    José C Del Río
    Instituto de Recursos Naturales y Agrobiologia de Sevilla, CSIC, PO Box 1052, E 41080 Seville, Spain
    J Agric Food Chem 57:10271-81. 2009
    ....
  57. ncbi Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles
    M L Ogletree
    Pharmacology Department, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey
    J Pharmacol Exp Ther 260:789-94. 1992
    ..1 to 30 nm.(abstract truncated at 250 words)..
  58. ncbi An endogenous retrovirus mediating deletion of alpha beta T cells?
    D L Woodland
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38106
    Nature 349:529-30. 1991
    ..The deletion of I-E-reactive V beta 5.2-bearing T cells is dependent on the coexpression of an I-E tolerogenic coligand (Etc)14 and the gene for one of ..
  59. ncbi Molecular cloning and expression of mouse mg(2+)-dependent protein phosphatase beta-4 (type 2C beta-4)
    S Kato
    Department of Biochemistry, Tohoku University, Sendai, Japan
    Arch Biochem Biophys 318:387-93. 1995
    ..These results suggest that the complex structure of MPP beta isoforms and their tissue- and developmental stage-specific expression reflect the variety of their physiological functions...
  60. ncbi Molecular organization of the gene encoding Xenopus laevis transforming growth factor-beta 5
    U D Vempati
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
    Biochem Mol Biol Int 45:997-1003. 1998
    ..TGF-beta 5 cDNA was cloned from Xenopus laevis and this isoform is unique to the amphibians...
  61. ncbi Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections
    M Noutsias
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
    Circulation 104:275-80. 2001
    ..Knowledge of CAR localization in the human cardiovascular system is limited but important with respect to CAR-dependent viral infections and gene transfer using CAR-dependent viral vectors...
  62. ncbi Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice
    Niels Reinmuth
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 63:2079-87. 2003
    ..The use of agents such as integrin antagonists that target multiple cell types involved in angiogenesis may be a more effective method of inhibiting angiogenesis than agents targeting only the endothelial cells...
  63. ncbi Rat DNA polymerase beta substitutes the repairing activity of DNA polymerase I in the lethal effect of UV light
    R Hernández-Escamilla
    Lab de Tecnología del DNA, ENCB, IPN México 11340 DF México
    Rev Latinoam Microbiol 44:58-64. 2002
    ..The oriC origin of replication from p beta 5 was replaced by the rep origin from pSC101 and named p beta 6...
  64. ncbi Dopamine D1/D5 receptor activation reverses NMDA receptor-dependent long-term depression in rat hippocampus
    Bruce G Mockett
    Department of Psychology, University of Otago, Dunedin, New Zealand
    J Neurosci 27:2918-26. 2007
    ..Reversal of the LTD by SKF 38393 was associated with rephosphorylation of this same residue. Together, these findings demonstrate a new role for dopamine in the neuromodulation of hippocampal LTD...
  65. doi Effects of a biologically relevant antioxidant on the dehydrogenative polymerization of coniferyl alcohol
    Anders Holmgren
    Division of Wood Chemistry and Pulp Technology, Department of Fibre and Polymer Technology, Royal Institute of Technology, KTH, 10044 Stockholm, Sweden
    Biomacromolecules 9:3378-82. 2008
    ..The chemistry of this antioxidant effect during dehydrogenative polymerization and the potential biological significance (cell wall lignification) of these observations are discussed...
  66. doi Beta-5 score to evaluate pig islet graft function in a primate pre-clinical model
    Yasuhiro Igarashi
    Laboratory of Experimental Surgery, Universite Catholique de Louvain, Faculte de Medecine, Brussels, Belgium
    Xenotransplantation 17:449-59. 2010
    ..We developed a composite scoring system to accurately assess pig islet function in pre-clinical primate studies...
  67. ncbi Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomes
    P J Dyson
    Clinical Research Centre, Harrow, Middlesex, UK
    Nature 349:531-2. 1991
    ..3 T cells by Mls-2a and Mls-3a; V beta 11 T cells by ligands encoded by independently segregating genes; and V beta 5 T cells by ligands encoded by two genes...
  68. pmc Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2
    M Bai
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973
    J Virol 68:5925-32. 1994
    ..cells did attach to surfaces coated with either protein and pretreatment of the cells with an integrin alpha v beta 5 monoclonal antibody reduced attachment to background levels...
  69. ncbi Role of thromboxane A2 in bradykinin-induced human isolated small bronchi contraction
    M Molimard
    Laboratoire de Pharmacologie, , France
    Eur J Pharmacol 278:49-54. 1995
    ..The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation...
  70. ncbi Cloning and sequence analysis of the rat tumor necrosis factor-encoding genes
    J Kwon
    Department of Cell Biology, University of Alabama at Birmingham 35294
    Gene 132:227-36. 1993
    ..The two genes are tandemly arranged with TNF-beta 5' to TNF-alpha and separated by approximately 1...
  71. ncbi The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrin
    B Mikami
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461
    Biochemistry 32:6836-45. 1993
    ..a smaller globular region formed by long loops (L3, L4, and L5) extending from beta-strands beta 3, beta 4, and beta 5. Between the two regions is a cleft that opens into a pocket whose floor contains the postulated catalytic center ..
  72. ncbi Cloning and tissue distribution of the human G protein beta 5 cDNA
    P G Jones
    Wyeth Ayerst Research, Princeton, NJ 08543, USA
    Biochim Biophys Acta 1402:288-91. 1998
    Heterotrimeric G proteins integrate signals between receptors and effector proteins. We have cloned the human beta 5 subunit from a human brain cDNA library...
  73. ncbi Effect of nepadutant at tachykinin NK(2) receptors in human intestine and urinary bladder
    R Patacchini
    Pharmacology Department, Research Laboratories, Menarini Ricerche SpA, via Rismondo 12 A, 50131, Florence, Italy
    Eur J Pharmacol 398:389-97. 2000
    ....
  74. ncbi Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes
    E Witt
    Institut fur Biochemie, Charité Humboldt University Medical School, Monbijoustr 2, Berlin, 10117, Germany
    J Mol Biol 301:1-9. 2000
    ..To analyse the role of the beta 5 propeptide for proper maturation and incorporation of the beta 5 subunit into the complex, human T2 cells, which ..
  75. ncbi New insights into p53 regulation and gene therapy for cancer
    A G Zeimet
    Department of Obstetrics and Gynecology, University Hospital, Innsbruck, Austria
    Biochem Pharmacol 60:1153-63. 2000
    ....
  76. ncbi Synchronous deletion of Mtv-superantigen-reactive thymocytes in the CD3(medium/high) CD4(+)CD8(+) subset
    M A Sheard
    Department of Cellular and Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, The Czech Republic
    Scand J Immunol 52:550-4. 2000
    ..Deletion of V beta 3(+), V beta 5(+), V beta 11(+), and V beta 17(+) Mtv-SAG-reactive thymocytes was found to occur synchronously in the most mature ..
  77. ncbi Progesterone and the oligodendroglial lineage: stage-dependent biosynthesis and metabolism
    N Gago
    INSERM U 488, Bicetre, France
    Glia 36:295-308. 2001
    ..PROG synthesis and metabolism and the dramatic changes in neurosteroidogenesis observed during the oligodendroglial differentiation may contribute to oligodendrocyte development or the myelination process...
  78. ncbi Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activation
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Medicine Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Basic Res Cardiol 97:334-42. 2002
    ....
  79. ncbi G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction
    D Scott Witherow
    Department of Molecular and Cellular Pharmacology and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 278:21307-13. 2003
    ..Gbeta5 complex and cyan fluorescence protein-tagged Galphaq, indicating a direct interaction between these molecules...
  80. ncbi Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion
    Vadim Pedchenko
    Division of Nephrology, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:2772-80. 2004
    ..Therefore, the RGD site, in addition to non-RGD motifs, may contribute to the mechanisms of endothelial cell adhesion in the human vasculature and the anti-angiogenic activity of the RGD-alpha3NC1 domain...
  81. ncbi alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro
    Riccardo E Nisato
    Department of Morphology, University Medical Center, Geneva, Switzerland
    Angiogenesis 6:105-19. 2003
    ..require cell-extracellular matrix interactions which are mediated in part via integrins alphav beta 3 and alphav beta 5, a formal demonstration that alphav beta 3 and alphav beta 5 are involved in endothelial-cell invasion and ..
  82. ncbi Integrins are not involved in the process of human sperm-oolemmal fusion
    Kazuo Sengoku
    Department of Obstetrics and Gynecology, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa, 0788510, Japan
    Hum Reprod 19:639-44. 2004
    ..We investigated whether integrins are required for the human sperm-oocyte binding and fusion processes...
  83. ncbi Solution structures of the inactive and BeF3-activated response regulator CheY2
    Hubert Riepl
    Lehrstuhl fur Genetik, Universitat Regensburg, D 93040 Regensburg, Germany
    J Mol Biol 338:287-97. 2004
    ..We propose that these new features of response regulator activation, compared to other two-component systems, are the key for the observed unique phosphorylation, dephosphorylation and motor control mechanisms in S.meliloti...
  84. ncbi alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts
    Amelia K Scaffidi
    Asthma and Allergy Research Institute and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia
    J Biol Chem 279:37726-33. 2004
    ..Our data provide a novel mechanism by which TGFbeta1 may contribute to abnormal wound healing and tissue fibrosis...
  85. ncbi Bisphosphonates: preclinical review
    Jonathan R Green
    Novartis Pharma AG, Klybeckstrasse 141, WKL 125 901, CH 4002 Basel, Switzerland
    Oncologist 9:3-13. 2004
    ..Further studies are needed to fully elucidate these biochemical mechanisms and to determine if the antitumor potential of bisphosphonates translates to the clinical setting...
  86. pmc Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Res 65:11545-52. 2005
    ....
  87. ncbi Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins
    Vincent C Chen
    Department of Chemistry, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
    J Proteome Res 5:2123-34. 2006
    ....
  88. ncbi Sexual function following radical prostatectomy: a prospective longitudinal study of cultural differences between Japanese and American men
    S Namiki
    Department of Urology, David Geffen School of Medicine, Los Angeles 90095 1738, CA, USA
    Prostate Cancer Prostatic Dis 11:298-302. 2008
    ..57; 95% CI=0.44-0.75). This study demonstrates that Japanese and American men experience different patterns of recovery of their sexual function and bother after RP. Ethnicity may be a contributing factor...
  89. ncbi Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats
    Rosemary J Santulli
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Rds, Spring House, PA 19477 0776, USA
    J Pharmacol Exp Ther 324:894-901. 2008
    ..Given this profile, JNJ-26076713 represents a potential therapeutic candidate for the treatment of age-related macular degeneration, macular edema, and proliferative diabetic retinopathy...
  90. doi Alpha v beta 3 and alpha v beta 5 integrins and their role in muscle precursor cell adhesion
    Andrea C M Sinanan
    Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, UK
    Biol Cell 100:465-77. 2008
    ....
  91. doi Establishment and functional characterization of a tracheal epithelial cell line RTEC11 from transgenic rats harboring temperature-sensitive simian virus 40 large T-antigen
    Yoshiaki Tabuchi
    Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Toyama, Japan
    Cell Biol Int 32:1344-52. 2008
    ..the expression levels of Muc1 (mucin 1) and Scgb1a1 (uteroglobin), non-ciliated secretory cell markers, and Tubb4 (tubulin beta 4), a ciliated cell marker, were significantly increased under the cell growth-restricted condition...
  92. doi Cyclic tetraureas with variable flexibility--synthesis, crystal structures and properties
    Denys Meshcheryakov
    Fachbereich Chemie, Pharmazie und Geowissenschaften, Abteilung Lehramt Chemie, Johannes Gutenberg Universitat Mainz, Duesbergweg 10 14, D 55099, Mainz, Germany
    Org Biomol Chem 6:3244-55. 2008
    ....
  93. pmc Two-stage genome-wide association study identifies integrin beta 5 as having potential role in bull fertility
    Jean M Feugang
    Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    BMC Genomics 10:176. 2009
    ..We performed a comprehensive genome wide analysis of single nucleotide polymorphisms (SNP) for bull fertility followed by a second-stage replication in additional bulls for a restricted set of markers...
  94. pmc An efficient chemical approach to bispecific antibodies and antibodies of high valency
    Julia I Gavrilyuk
    The Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:3716-20. 2009
    ..Additionally, this approach should be applicable to chemically programmed vaccines...
  95. pmc Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein
    Leelamma M Panicker
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1752, USA
    J Neurochem 113:1101-12. 2010
    ..These results suggest that R7BP contributes significantly to the nuclear localization of endogenous G beta(5)/R7-RGS complex in brain...
  96. pmc Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells
    Ying Mei
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Mater 9:768-78. 2010
    ..The structure-function methodology employed herein provides a general framework for the combinatorial development of synthetic substrates for stem cell culture...
  97. pmc Novel betapapillomavirus associated with hand and foot papillomas in a cynomolgus macaque
    C E Wood
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Vet Pathol 48:731-6. 2011
    ..These findings characterize a new nonhuman beta-PV and provide additional support for the idea that tissue tropism among ancestral primate PVs developed prior to divergence of certain Old World primate lineages...
  98. pmc Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation
    Y F Lin
    Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan, ROC
    Cell Death Dis 3:e434. 2012
    ....
  99. pmc A de novo mutation in the β-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum
    Cas Simons
    Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia
    Am J Hum Genet 92:767-73. 2013
    ..probands, which revealed that all eleven H-ABC-diagnosed individuals carry the same de novo single-nucleotide TUBB4A mutation resulting in nonsynonymous change p.Asp249Asn...
  100. pmc Pathogenic variants in TUBB4A are not found in primary dystonia
    Satya R Vemula
    From the Departments of Neurology and Anatomy and Neurobiology S R V, J X, M S L, University of Tennessee Health Science Center, Memphis, TN Bastian Voice Institute R W B, Downers Grove, IL Clinic for Child Neurology and Psychiatry D M, Medical Faculty University of Belgrade, Serbia and New York Center for Voice and Swallowing Disorders A B, NY
    Neurology 82:1227-30. 2014
    To determine the contribution of TUBB4A, recently associated with DYT4 dystonia in a pedigree with "whispering dysphonia" from Norfolk, United Kingdom, to the etiopathogenesis of primary dystonia.
  101. pmc G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization
    J Christopher Octeau
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island, United States of America
    PLoS ONE 9:e105791. 2014
    G beta 5 (Gbeta5, Gβ5) is a unique G protein β subunit that is thought to be expressed as an obligate heterodimer with R7 regulator of G protein signaling (RGS) proteins instead of with G gamma (Gγ) subunits...

Research Grants27

  1. Interaction of RGS Protein with G beta subunit G beta 5.
    Vladlen Z Slepak; Fiscal Year: 2013
    ..This research will contribute to understanding, at the molecular level, of cognitive, sensory, motor, metabolic and other functions of the nervous system. ..
  2. ROLE OF VITRONECTIN IN TUMOR CELL METASTASIS
    RICHARD CHERNY; Fiscal Year: 1992
    ..The isolated recombinant wild-type VN promotes cell adhesion similar to plasma- derived VN. This demonstrates a viable system to study the questions raised...
  3. Alpha v beta 5 integrin in retinal pigment epithelium
    SILVIA FINNEMANN; Fiscal Year: 2004
    ..The mechanisms of these interactions and the unique localization of v5 integrin in RPE are conserved among species. Exploring the 5 null mouse is thus important to understand human disease. ..
  4. Regulation of cell migration/metastasis by Src
    JILL RICONO; Fiscal Year: 2005
    ..Integrin alpha V beta 5 is known to cooperate with growth factor receptors and promote intracellular signaling events that influence cell ..
  5. ALPHA V INTEGRINS AND PULMONARY VASCULAR DEVELOPMENT
    SUSAN SCHACHTNER; Fiscal Year: 2001
    ..research outlined in this proposal investigates the role of specific adhesion molecules (alpha v beta 3 , alpha v beta 5 integrins), in endothelial cell differentiation, migration and adhesion in the developing vessels in the lung...
  6. Molecular Imaging of Neoplasia Using Nanoparticles
    G Reddy; Fiscal Year: 2002
    ..abstract_text> ..
  7. Contrasting Properties of Integrin Cytoplasmic Domains
    Renata Pasqualini; Fiscal Year: 2004
    ..v beta3 and alpha v beta5 focal adhesion preparations and panning of phage display peptide libraries on beta3 and beta 5 cytoplasmic domains...
  8. Structural Studies of Bacterial Competence Proteins
    John Cavanagh; Fiscal Year: 2006
    ..subtilis, but also in other important gram-positive (e.g. Streptococcus pneumoniae) and gram-negative (e.g. Neisseria gonorrhoeae and Haemophihts influenza) bacteria. ..
  9. TAP20, NOVEL INTEGRIN MODULATING PROTEIN
    Shaoqing Tang; Fiscal Year: 2001
    ..We anticipate that these studies should provide data that will be useful in designing new strategic for pharmacologic intervention in ischemic vascular disease and cancer. ..
  10. Exercise-based Motivational Interviewing for Fibromyalgia
    DENNIS CHUA ANG; Fiscal Year: 2010
    ..Furthermore, if proven efficacious, Ml could readily be applied to other chronically painful conditions (e.g. chronic back pain). ..
  11. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
  12. Membrane Targeting of G Proteins
    Philip Wedegaertner; Fiscal Year: 2007
    ..abstract_text> ..
  13. Postdoctoral Training Program in Cancer Epidemiology
    Linda Van Horn; Fiscal Year: 2008
    ..The ultimate success of the Program will be determined by the future contributions of the Fellows to the field in the academic/research setting. ..
  14. CELL ADHESION MOLECULES OF MAMMALIAN FERTILIZATION
    Janice Evans; Fiscal Year: 2008
    ..This research also will also address fundamental questions in cell adhesion biology by examining this interesting, biologically relevant cell-cell interaction event. ..
  15. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
  16. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  17. Tracking Urogenital Sinus Cell Progeny
    ROBERT SIKES; Fiscal Year: 2004
    ..abstract_text> ..
  18. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  19. ENDOTHELIAL SIGNALING MECHANISMS IN LUNG INJURY
    Sunita Bhattacharya; Fiscal Year: 2005
    ..These mechanisms are highly relevant to the general understanding of the lung inflammatory response. No previous understanding of these mechanisms exists for lung endothelium in vivo. The proposed studies will be novel. ..
  20. Role of Osteopontin in Tumor Promotion
    Pi Ling Chang; Fiscal Year: 2005
    ..Together, these studies will provide a better understanding of the role of OPN in tumor promotion and may contribute to the design of a mechanism-based strategy for cancer prevention. ..
  21. CELL SURFACE STRUCTURE AND TRANSFORMATIONS
    Richard Hynes; Fiscal Year: 2005
    ..Evaluation of the functions of cell adhesion proteins and the consequences of their misexpression in metastatic cells will lead to new leads for therapeutic interventions against metastasis. ..
  22. MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATION
    PATRICK CAMMARATA; Fiscal Year: 2004
    ..This study proposes to test the potential usefulness of enhancing myo-inositol efflux through chloride channels as a means for drug therapy to relieve intrafiber osmotic stress. ..
  23. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..abstract_text> ..
  24. Osteopontin and microenvironment of initiated cells
    Pi Ling Chang; Fiscal Year: 2010
    ..These proposed in vivo and in vitro studies will shed light on the molecular mechanism(s) by which a matricellular protein enhances the survival of transforming cells during early tumor promotion. ..
  25. ETHNIC DISPARITY IN THE USE OF JOINT ARTHROPLASTY
    DENNIS ANG; Fiscal Year: 2007
    ..The Program Director, Munro Peacock, M.D., was appointed in July 1987. The GCRC was ..
  26. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..

Patents1

  1. Primers for synthesizing full length cDNA clones and their use
    Patent Number: EP1396543-A2; Date:2004-03-10