TTBK2

Summary

Gene Symbol: TTBK2
Description: tau tubulin kinase 2
Alias: SCA11, TTBK, tau-tubulin kinase 2
Species: human

Top Publications

  1. pmc TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development
    Michale Bouskila
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 437:157-67. 2011
  2. pmc The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis
    Sarah C Goetz
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Cell 151:847-58. 2012
  3. ncbi Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
    Henry Houlden
    Department of Molecular Neuroscience, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Nat Genet 39:1434-6. 2007
  4. pmc The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis
    You Fu Pan
    Genome Institute of Singapore, Singapore
    Int J Biol Sci 6:163-71. 2010
  5. pmc Autosomal dominant cerebellar ataxia type III: linkage in a large British family to a 7.6-cM region on chromosome 15q14-21.3
    P F Worth
    Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Am J Hum Genet 65:420-6. 1999
  6. doi X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors
    Yafeng Xue
    Discovery Sciences, AstraZeneca R and D Molndal, 43183 Mölndal Sweden
    ChemMedChem 8:1846-54. 2013
  7. pmc C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals
    Xuan Ye
    Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, PA 16802
    Proc Natl Acad Sci U S A 111:2164-9. 2014
  8. pmc The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor
    Susan E Kiefer
    Molecular Discovery Technologies, Bristol Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543 4000, USA
    Acta Crystallogr F Struct Biol Commun 70:173-81. 2014
  9. pmc Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole
    Lukas Cajanek
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 111:E2841-50. 2014
  10. doi Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis
    Toshiaki Oda
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, 980 8578, Japan
    Genes Cells 19:927-40. 2014

Research Grants

  1. Sarah Goetz; Fiscal Year: 2014

Scientific Experts

  • Erich A Nigg
  • Y Xue
  • Suzanne Granhøj Lindquist
  • Harald Lund
  • H Houlden
  • A Brusco
  • A Filla
  • Pavel A Karpov
  • Alexandra Durr
  • Peter K Jackson
  • Sarah Goetz
  • Shinji Sato
  • Tsuneya Ikezu
  • Florian Lang
  • Hong Jiang
  • Junling Wang
  • Qian Xu
  • Jiqing Xu
  • Qingwen Xu
  • Guang Bin Zha
  • Kristina Nieding
  • Si Hyung Lee
  • Ning Zhang
  • Takashi Watanabe
  • Jung Chi Liao
  • Hirohide Asai
  • Toshiaki Oda
  • Xuan Ye
  • Lukas Cajanek
  • Nicole F Liachko
  • Susan E Kiefer
  • Noor Esoof
  • Dario R Alessi
  • Barbara E Tanos
  • Ahmad Almilaji
  • Shinsuke Fujioka
  • Andrea H Nemeth
  • Meghan K Rains
  • Carlos Munoz
  • Kay Seidel
  • Sarah C Goetz
  • Claus Bender
  • Ioana Alesutan
  • Moumita Chaki
  • Nan Nan Yu
  • Michale Bouskila
  • José Luis Vázquez-Higuera
  • Beisha Tang
  • Qian Pan
  • Lifang Lei
  • Lu Shen
  • Kun Xia
  • Anne Weissbach
  • Peter Bauer
  • You Fu Pan
  • Christine Zühlke
  • Satoshi Okuyama
  • Russell J Swan
  • Kinya Ishikawa
  • Michael T Jacobsen
  • Ulf Edener
  • Hongying Qi
  • Janel Johnson
  • Michiko Kitano-Takahashi
  • K Tomizawa
  • Kun Ling
  • Cheol Hee Kim
  • Jinghua Hu
  • Joon Kim
  • Mi Shen
  • Yuxia Zhang
  • Qing Wei
  • Sven G Meuth
  • Sheng Yi
  • Jun Young Seo
  • Xiao Song Gu
  • Nathalie Strutz-Seebohm
  • Tae Ik Choi
  • Veronika Matschke
  • Guiscard Seebohm
  • Mi Sun Lee
  • Ming Yi Chung
  • Yan Huang
  • Hyowon Hong
  • Daan M F van Aalten
  • Robert Gourlay
  • Fumiyoshi Ishidate
  • Aya Shirahige
  • Kozo Kaibuchi
  • Nariko Arimura

Detail Information

Publications55

  1. pmc TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development
    Michale Bouskila
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 437:157-67. 2011
    Mutations that truncate the C-terminal non-catalytic moiety of TTBK2 (tau tubulin kinase 2) cause the inherited, autosomal dominant, SCA11 (spinocerebellar ataxia type 11) movement disorder...
  2. pmc The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis
    Sarah C Goetz
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Cell 151:847-58. 2012
    ..Here, we show that Tau tubulin kinase 2 (TTBK2) is a dedicated regulator of the initiation of ciliogenesis in vivo...
  3. ncbi Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
    Henry Houlden
    Department of Molecular Neuroscience, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Nat Genet 39:1434-6. 2007
    ..We identified mutations in the gene encoding tau tubulin kinase 2 (TTBK2) as the cause of spinocerebellar ataxia type 11...
  4. pmc The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis
    You Fu Pan
    Genome Institute of Singapore, Singapore
    Int J Biol Sci 6:163-71. 2010
    ..Therefore, these results suggest that WAFL may play an important role in endocytosis and subsequent membrane trafficking by interacting with AP2 through KIAA0196 and KIAA1033...
  5. pmc Autosomal dominant cerebellar ataxia type III: linkage in a large British family to a 7.6-cM region on chromosome 15q14-21.3
    P F Worth
    Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Am J Hum Genet 65:420-6. 1999
    ..We excluded linkage of the disease phenotype to this region in the second family. These results indicate the presence of two additional ADCA III loci and more clearly define the genetic heterogeneity of ADCA III...
  6. doi X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors
    Yafeng Xue
    Discovery Sciences, AstraZeneca R and D Molndal, 43183 Mölndal Sweden
    ChemMedChem 8:1846-54. 2013
    ..These conformational changes necessary for the binding of compound 2 are likely the basis of the slow kinetics. This first TTBK1 structure can assist the discovery of novel inhibitors for the treatment of Alzheimer's disease. ..
  7. pmc C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals
    Xuan Ye
    Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, PA 16802
    Proc Natl Acad Sci U S A 111:2164-9. 2014
    ..Furthermore, loss of C2cd3 results in failure in the recruitment of Ttbk2 to the ciliary basal body as well as the removal of Cp110 from the ciliary basal body, two critical steps in ..
  8. pmc The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor
    Susan E Kiefer
    Molecular Discovery Technologies, Bristol Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543 4000, USA
    Acta Crystallogr F Struct Biol Commun 70:173-81. 2014
    ..X-ray diffraction data were collected and the structure of TTBK1 was determined by molecular replacement both as an apo structure and in complex with a kinase inhibitor. ..
  9. pmc Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole
    Lukas Cajanek
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 111:E2841-50. 2014
    ..leads to early defects in ciliogenesis, reminiscent of the phenotypic consequences of mutations in TTBK2 (Tau tubulin kinase 2)...
  10. doi Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis
    Toshiaki Oda
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, 980 8578, Japan
    Genes Cells 19:927-40. 2014
    ..Recruitment of Tau tubulin kinase-2 (TTBK2) to the mother centriole and subsequent removal of CP110 and its interactor Cep97 are crucial for the initiation ..
  11. pmc The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43
    Nicole F Liachko
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, United States of America Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 10:e1004803. 2014
    ..In this kinome-wide survey, we identified homologs of the tau tubulin kinases 1 and 2 (TTBK1 and TTBK2), which were also identified in a prior screen for kinase modifiers of TDP-43 behavioral phenotypes...
  12. pmc Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1
    Ning Zhang
    Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom, and
    J Neurosci 35:2492-507. 2015
    ..We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and ..
  13. pmc TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation
    Takashi Watanabe
    Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Showa, Nagoya 466 8550, Japan
    J Cell Biol 210:737-51. 2015
    ..However, how EBs contribute to MT dynamics through +TIPs remains elusive. We focused on tau-tubulin kinase 2 (TTBK2) as an EB1/3-binding kinase and confirmed that TTBK2 acted as a +TIP...
  14. pmc Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
    Qingwen Xu
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Commun 7:10777. 2016
    ..PIPKIγ counteracts INPP5E in regulating tau-tubulin kinase-2 (TTBK2) recruitment to the basal body, which promotes the removal of microtubule capping protein CP110 and the subsequent ..
  15. doi A Novel TTBK2 De Novo Mutation in a Danish Family with Early-Onset Spinocerebellar Ataxia
    Suzanne Granhøj Lindquist
    Danish Dementia Research Centre, Neurogenetics Clinic, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Cerebellum 16:268-271. 2017
    ..A novel frameshift mutation (c.1205_1207delinsA) in the tau-tubulin kinase 2 encoding gene, TTBK2, was identified, which was compatible with a diagnosis of SCA11...
  16. pmc MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment
    Si Hyung Lee
    Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea
    Sci Rep 6:27284. 2016
    ..NDE1, MCRS1 played a positive role for the initiation of ciliogenesis, possibly through its interaction with TTBK2. Zebrafish with homozygous mcrs1 mutants exhibited a reduction in the size of the brain and the eye due to ..
  17. doi Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2
    Kristina Nieding
    Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases IfGH, University Hospital Muenster, Muenster, Germany
    Cell Physiol Biochem 39:1444-52. 2016
    ..autosomal dominant spinocerebellar ataxia type 11 (SCA11) is caused by loss of function mutations of TTBK2 (tau tubulin kinase 2). Mutations observed in patients with SCA11 include truncated TTBK2(450)...
  18. pmc Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration
    Guang Bin Zha
    Jiangsu Key Laboratory of Neuroregeneration, Co innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China
    Neural Regen Res 11:1506-1511. 2016
    ..Thus, these results showed that the expression of tau was changed following sciatic nerve crush, suggesting that tau may be involved in peripheral nerve repair and regeneration...
  19. doi The centrosome duplication cycle in health and disease
    Erich A Nigg
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland Electronic address
    FEBS Lett 588:2366-72. 2014
    ..We also present recent data on the role of a disease-related centriole-associated protein complex, Cep164-TTBK2, in ciliogenesis.
  20. pmc Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1
    Hirohide Asai
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts
    Am J Pathol 184:808-18. 2014
    ..These data suggest that TTBK1 accelerates motor neuron neurodegeneration by recruiting proinflammatory monocytes and enhancing sensitivity to neurotoxicity in inflammatory conditions. ..
  21. pmc TTBK2: a tau protein kinase beyond tau phosphorylation
    Jung Chi Liao
    Institute of Atomic and Molecular Sciences, Academia Sinica, No 1, Roosevelt Road, Section 4, Taipei 10617, Taiwan
    Biomed Res Int 2015:575170. 2015
    b>Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes...
  22. pmc Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
    Moumita Chaki
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 150:533-48. 2012
    ..Our findings link degenerative diseases of the kidney and retina, disorders of increasing prevalence, to mechanisms of DDR...
  23. pmc Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model
    Andrea H Nemeth
    1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK
    Brain 136:3106-18. 2013
    ..Our pathogenicity interpretation pathway predicted 13 different mutations in eight different genes: PRKCG, TTBK2, SETX, SPTBN2, SACS, MRE11, KCNC3 and DARS2 of which nine were novel including one causing a newly described ..
  24. doi Upregulation of Na+,Cl(-)-coupled betaine/γ-amino-butyric acid transporter BGT1 by Tau tubulin kinase 2
    Ahmad Almilaji
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 32:334-43. 2013
    The serine/threonine kinase Tau-tubulin-kinase 2 (TTBK2) is expressed in various tissues including kidney, liver and brain. Loss of function mutations of TTBK2 lead to autosomal dominant spinocerebellar ataxia type 11 (SCA11)...
  25. pmc Electrochemical investigations into kinase-catalyzed transformations of tau protein
    Meghan K Rains
    Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, M1C1A4, Canada
    ACS Chem Neurosci 4:1194-203. 2013
    ..of the following protein kinases: Sarcoma related kinase (Src), Abelson tyrosine kinase (Abl), tau-tubulin kinase (TTBK), proto-oncogene tyrosine protein kinase Fyn (Fyn), and glycogen synthase kinase 3-β (Gsk-3β)...
  26. pmc Centriole distal appendages promote membrane docking, leading to cilia initiation
    Barbara E Tanos
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genes Dev 27:163-8. 2013
    ..Undocked centrioles fail to recruit TTBK2 or release CP110, the two earliest modifications found on centrioles prior to cilia assembly, revealing centriole-..
  27. pmc Autosomal dominant cerebellar ataxia type III: a review of the phenotypic and genotypic characteristics
    Shinsuke Fujioka
    Department of Neurology at Mayo Clinic, 4500 San Pablo Road Cannaday Bldg 2 E, Jacksonville, FL 32224, USA
    Orphanet J Rare Dis 8:14. 2013
    ..The incidence of ADCA Type III is unknown. ADCA Type III consists of six subtypes, SCA5, SCA6, SCA11, SCA26, SCA30, and SCA31. The subtype SCA6 is the most common...
  28. doi TTBK2 kinase: linking primary cilia and cerebellar ataxias
    Peter K Jackson
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94070, USA
    Cell 151:697-9. 2012
    ..A new mouse mutant in the TTBK2 kinase fails to make cilia, and shows neural tube and Sonic hedgehog signaling defects...
  29. doi Brain pathology of spinocerebellar ataxias
    Kay Seidel
    Dr Senckenbergisches Chronomedizinisches Institut, Goethe University, Theodor Stern Kai 7, 60950, Frankfurt Main, Germany
    Acta Neuropathol 124:1-21. 2012
    ..g. retinal degeneration in SCA7, tau aggregation in SCA11, dentate calcification in SCA20, protein depositions in the Purkinje cell layer in SCA31, azoospermia in SCA32, ..
  30. doi Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2
    Ioana Alesutan
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Cell Physiol Biochem 30:458-65. 2012
    The Tau-tubulin-kinase 2 (TTBK2) is a serine/threonine kinase expressed in various tissues including tumors. Up-regulation of TTBK2 increases resistance of tumor cells against antiangiogenic treatment and confers cell survival...
  31. doi Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain
    Harald Lund
    Neuroscience Department, AstraZeneca R and D, Sodertalje, Sweden
    Brain Pathol 23:378-89. 2013
    ..These data suggest a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early/intermediate stage in NFT formation...
  32. doi PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines
    Claus Bender
    Department of Molecular Biology, Max Planck Institute, Martinsried, Germany
    Int J Cancer 131:E45-55. 2012
    ..PRKX, TTBK2 and RSK4 expression...
  33. ncbi A novel tau-tubulin kinase from bovine brain
    M Takahashi
    Mitsubishi Kasei Institute of Life Sciences Project 2, Tokyo, Japan
    FEBS Lett 372:59-64. 1995
    ..The enzyme requires no second messenger and is inhibited with high concentration of heparin, but not by inhibitors of CKI. These results indicate that this enzyme, tau-tubulin kinase is novel and distinct from TPKI, II and CKI, II...
  34. pmc Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein
    Michiko Kitano-Takahashi
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:602-4. 2007
    Tau-tubulin kinase 2 (TTBK2) is a Ser/Thr kinase that putatively phosphorylates residues Ser208 and Ser210 (numbered according to a 441-residue human tau isoform) in tau protein...
  35. ncbi Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation
    Shinji Sato
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 98:1573-84. 2006
    ..We conclude that TTBK1 is a neuron-specific dual kinase involved in tau phosphorylation at AD-related sites and is also associated with tau aggregation...
  36. ncbi Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families
    Alfredo Brusco
    Dipartimento di Genetica, Biologia e Biochimica, Università di Torino and Unitá Operativa Genetica Medica, Ospedale San Giovanni Battista di Torino, Torino, Italy
    Arch Neurol 61:727-33. 2004
    ....
  37. ncbi A novel autosomal dominant spinocerebellar ataxia (SCA22) linked to chromosome 1p21-q23
    Ming Yi Chung
    Department of Medical Research and Education, Taipei Veterans General Hospital, and Genome Research Centre, National Yang Ming University, Taiwan
    Brain 126:1293-9. 2003
    ..Six additional loci, SCA4, SCA5, SCA11, SCA13, SCA14 and SCA16 have also been mapped...
  38. pmc Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1
    Orly Dgany
    Pediatric Hematology Laboratory, Felsenstein Research Center, Rabin Medical Center, Petah Tikva, Israel
    Am J Hum Genet 71:1467-74. 2002
    ..The specific mechanisms by which codanin-1 underlies normal erythropoiesis remain to be elucidated...
  39. ncbi Early onset autosomal dominant dementia with ataxia, extrapyramidal features, and epilepsy
    A Filla
    Department of Neurological Sciences, Federico II University, Naples, Italy
    Neurology 58:922-8. 2002
    ..To perform a clinical and molecular study of a large autosomal dominant family with a complex neurologic syndrome that comprises early-onset dementia, extrapyramidal and cerebellar features, and epilepsy...
  40. doi Clinical and genetic analysis of spinocerebellar ataxia type 11
    Janel Johnson
    Neurogenetics, Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Cerebellum 7:159-64. 2008
    ..Here we update readers on the current progress on SCA11 and the identification of the disease gene...
  41. ncbi Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau
    K Tomizawa
    Project 8, Mitsubishi Kasei Institute of Life Sciences, Machida shi, Tokyo, Japan
    FEBS Lett 492:221-7. 2001
    ..Our immunoblot analysis demonstrated that TTK is ubiquitously distributed in the rat tissues, and that it is developmentally regulated in the rat brain...
  42. doi Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1
    Shinji Sato
    Department of Pharmacology and Experimental Neuroscience and Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurosci 28:14511-21. 2008
    ..These data suggest that TTBK1 in AD brain may be one of the underlying mechanisms inducing CDK5 and calpain activation, NR2B downregulation, and subsequent memory dysfunction...
  43. doi Missense exchanges in the TTBK2 gene mutated in SCA11
    Ulf Edener
    Institut fur Humangenetik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Neurol 256:1856-9. 2009
    ..Recently, two frameshift mutations in the tau tubulin kinase 2 gene (TTBK2) were reported to cause SCA11...
  44. doi Spinocerebellar ataxia type 11 in the Chinese Han population
    Qian Xu
    Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, China
    Neurol Sci 31:107-9. 2010
    ..Researchers have recently found that SCA type 11 (SCA11) is associated with mutations in the TTBK2 gene...
  45. doi Asator, a tau-tubulin kinase homolog in Drosophila localizes to the mitotic spindle
    Hongying Qi
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Dev Dyn 238:3248-56. 2009
    ..The finding that Asator localizes to the spindle region during mitosis and directly can interact with Megator suggests that its kinase activity may be involved in regulating microtubule dynamics and microtubule spindle function...
  46. ncbi [Molecular genetic approach to spinocerebellar ataxias]
    Kinya Ishikawa
    Department of Neurology and Neurological Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Rinsho Shinkeigaku 49:907-9. 2009
    ..dynamic mutations, static mutations, such as missense mutations and deletions, have been identified to cause SCA5, SCA11, SCA13, SCA14, SCA15 and SCA27...
  47. doi Spinocerebellar ataxias in mainland China: an updated genetic analysis among a large cohort of familial and sporadic cases
    Junling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:482-9. 2011
    ..To undertake an updated genetic spectrum analysis in patients with hereditary spinocerebellar ataxia (SCA) in mainland China...
  48. doi Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort
    José Luis Vázquez-Higuera
    Neurology Service and CIBERNED, Marques de Valdecilla University Hospital, University of Cantabria, Avda Valdecilla, 39008 Santander, Spain
    Neurobiol Aging 32:550.e5-9. 2011
    ..57, p=0.023), which are in strong linkage disequilibrium, had a lower risk of developing AD than subjects homozygotes and heterozygotes for the major allele. TTBK1 is a promising new candidate tau phosphorylation-related gene for AD risk...
  49. doi Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese
    Nan Nan Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
    Neurosci Lett 491:83-6. 2011
    ..78, P=0.037). This study provides the evidence that variations in the TTBK1 gene may play an important role in the pathogenesis of sporadic LOAD in a Han Chinese population...
  50. doi Autosomal dominant cerebellar ataxias: polyglutamine expansions and beyond
    Alexandra Durr
    Université Pierre et Marie Curie Paris, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975, Paris, France
    Lancet Neurol 9:885-94. 2010
    ..signalling (SCA15/16/ITPR1), channel function (SCA13/KCNC3, SCA14/PRKCG, SCA27/FGF14), tau regulation (SCA11/TTBK2), and mitochondrial activity (SCA28/AFG3L2) or RNA alteration (SCA31/BEAN-TK2)...
  51. doi Spinocerebellar ataxia type 11 (SCA11) is an uncommon cause of dominant ataxia among French and German kindreds
    Peter Bauer
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    J Neurol Neurosurg Psychiatry 81:1229-32. 2010
    ..Recently, a large British pedigree linked to SCA11 has been reported to carry a mutation in the TTBK2 gene...
  52. doi Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15
    Anne Weissbach
    Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck, Germany
    Mov Disord 25:1577-82. 2010
    ..The maximum model-based multipoint LOD score was 1.75. This region is only 4.3 Mb away from the SCA11 (TTBK2) gene...
  53. pmc Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases
    Pavel A Karpov
    Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine
    BMC Genomics 11:S14. 2010
    ..in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified...
  54. doi Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice
    Jiqing Xu
    Department of Pharmacology and Experimental Neuroscience and Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5930, USA
    FASEB J 24:2904-15. 2010
    ..These data suggest that TTBK1 up-regulation enhances tau phosphorylation and oligomerization, whose toxicity results in enhanced neurodegeneration and locomotor dysfunction in a tauopathy animal model...

Research Grants1

  1. Sarah Goetz; Fiscal Year: 2014
    ..mouse mutant I have begun to characterize during my postdoctoral studies, which is a null allele of Tau tubulin kinase 2 (Ttbk2)...